[Hub]/) : Traits : Alzheimer’s Disease (including proxy) : ← →

chr17:4,041,725-5,725,694

Best TWAS P=1.52e-10 · Best GWAS P=1.26e-10 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	AC012146.7	0.15	0.09	enet	29	0.10	7.1e-09	5.4	-5.6	1.8e-08	-0.66	0.25	0.75	FALSE
2	GTEx	Adipose Visceral Omentum	AC012146.7	0.16	0.13	lasso	5	0.11	3.6e-06	5.4	-5.5	4.2e-08	-0.76	0.09	0.90	FALSE
3	GTEx	Artery Coronary	AC012146.7	0.20	0.17	lasso	3	0.12	6.2e-05	5.4	-5.5	5.0e-08	-0.69	0.12	0.38	FALSE
4	GTEx	Artery Tibial	AC012146.7	0.15	0.14	lasso	2	0.18	1.1e-13	5.4	-5.6	2.7e-08	-0.71	0.36	0.64	FALSE
5	GTEx	Cells EBV-transformed lymphocytes	AC012146.7	0.23	0.18	lasso	3	0.12	8.0e-05	5.0	-5.2	2.2e-07	-0.76	0.16	0.35	FALSE
6	GTEx	Cells Transformed fibroblasts	ZNF232	0.14	0.13	enet	25	0.15	1.8e-11	5.5	-5.2	2.5e-07	-0.74	0.18	0.82	FALSE
7	GTEx	Esophagus Muscularis	AC012146.7	0.28	0.17	enet	29	0.23	7.1e-14	5.4	-5.4	6.2e-08	-0.66	0.22	0.78	FALSE
8	GTEx	Heart Left Ventricle	AC012146.7	0.17	0.10	lasso	6	0.05	8.0e-04	5.6	-5.4	5.3e-08	-0.74	0.09	0.83	FALSE
9	GTEx	Liver	AC012146.7	0.23	0.14	lasso	4	0.06	8.7e-03	5.4	-5.4	8.1e-08	-0.76	0.07	0.17	FALSE
10	GTEx	Lung	AC012146.7	0.10	0.01	enet	18	0.06	2.2e-05	5.5	-5.1	2.9e-07	-0.61	0.28	0.63	FALSE
11	GTEx	Muscle Skeletal	AC012146.7	0.06	0.04	lasso	7	0.02	1.1e-02	5.5	-5.6	2.7e-08	-0.78	0.09	0.89	FALSE
12	GTEx	Nerve Tibial	MINK1	0.07	0.01	lasso	5	0.00	5.2e-01	5.5	-5.3	8.8e-08	-0.76	0.10	0.27	FALSE
13	GTEx	Nerve Tibial	AC012146.7	0.32	0.09	lasso	11	0.22	2.1e-15	5.4	-5.2	2.2e-07	-0.61	0.35	0.65	FALSE
14	GTEx	Pituitary	AC012146.7	0.16	0.10	lasso	4	0.10	1.9e-03	5.6	-5.7	1.3e-08	-0.77	0.14	0.20	FALSE
15	GTEx	Skin Not Sun Exposed Suprapubic	AC012146.7	0.14	0.03	enet	9	0.10	3.4e-06	5.4	-5.5	3.3e-08	-0.64	0.16	0.68	FALSE
16	GTEx	Skin Sun Exposed Lower leg	AC012146.7	0.21	0.07	enet	17	0.18	1.3e-14	5.5	-5.4	6.1e-08	-0.63	0.15	0.85	FALSE
17	GTEx	Spleen	AC012146.7	0.34	0.37	lasso	1	0.36	4.8e-10	5.4	-5.4	7.3e-08	-0.75	0.27	0.66	FALSE
18	GTEx	Stomach	AC012146.7	0.21	0.21	lasso	4	0.18	8.7e-09	5.4	-5.6	2.8e-08	-0.76	0.30	0.70	FALSE
19	GTEx	Thyroid	CAMTA2	0.21	0.08	lasso	3	0.11	7.4e-09	5.5	5.6	1.7e-08	0.84	0.08	0.92	FALSE
20	GTEx	Thyroid	AC012146.7	0.15	0.09	enet	16	0.16	6.5e-12	5.6	-5.5	3.5e-08	-0.65	0.16	0.84	FALSE
21	GTEx	Thyroid	RP5-1050D4.3	0.07	0.08	lasso	3	0.03	2.8e-03	5.5	5.6	2.1e-08	0.81	0.03	0.97	FALSE
22	The Cancer Genome Atlas	Breast Invasive Carcinoma	C17orf87	0.03	0.00	blup	38	0.02	2.6e-04	-2.5	5.2	2.1e-07	0.65	0.01	0.78	FALSE
23	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ZNF232	0.11	0.03	lasso	3	0.05	4.5e-03	5.6	-5.4	6.6e-08	-0.76	0.00	0.80	FALSE
24	The Cancer Genome Atlas	Thyroid Carcinoma	C17orf87	0.06	0.04	lasso	2	0.02	3.4e-03	6.4	6.4	1.5e-10	0.99	0.00	0.99	TRUE