Best TWAS P=1.22e-14 · Best GWAS P=1.08e-16 conditioned to 0.0011
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Nerve Tibial | MS4A6A | 0.08 | 0.02 | lasso | 4 | 0.02 | 1.5e-02 | -6.4 | 6.4 | 1.6e-10 | -0.77 | 0.12 | 0.47 | FALSE |
| 2 | GTEx | Whole Blood | MS4A6A | 0.05 | 0.03 | lasso | 5 | 0.03 | 6.1e-04 | -7.3 | 7.3 | 2.6e-13 | -0.91 | 0.16 | 0.80 | FALSE |
| 3 | METSIM | Adipose | MS4A4A | 0.04 | 0.04 | blup | 402 | 0.05 | 7.2e-08 | 5.6 | 7.0 | 2.2e-12 | -0.71 | 0.06 | 0.94 | FALSE |
| 4 | NTR | Blood | MS4A6A | 0.03 | 0.02 | lasso | 6 | 0.02 | 5.4e-07 | -6.5 | 6.9 | 5.7e-12 | -0.90 | 0.06 | 0.94 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | MS4A4A | 0.06 | 0.03 | blup | 423 | 0.04 | 1.9e-05 | 5.7 | 5.3 | 1.0e-07 | -0.46 | 0.96 | 0.03 | FALSE |
| 6 | YFS | Blood | MS4A6A | 0.13 | 0.10 | enet | 33 | 0.11 | 2.5e-35 | -6.5 | 6.8 | 7.3e-12 | -0.90 | 0.28 | 0.72 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MS4A4A | 0.04 | 0.03 | blup | 79 | 0.04 | 7.2e-08 | 6.9 | 7.3 | 2.5e-13 | -0.67 | 0.51 | 0.49 | FALSE |
| 8 | The Cancer Genome Atlas | Colon Adenocarcinoma | MS4A4A | 0.06 | 0.04 | blup | 79 | 0.05 | 1.1e-03 | 5.2 | 5.8 | 5.4e-09 | -0.67 | 0.18 | 0.61 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MS4A2 | 0.05 | 0.03 | lasso | 3 | 0.03 | 4.1e-04 | -6.8 | -6.5 | 1.0e-10 | 0.85 | 0.01 | 0.96 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MS4A4A | 0.05 | 0.07 | lasso | 2 | 0.06 | 4.6e-07 | 5.6 | 5.7 | 1.5e-08 | -0.58 | 0.95 | 0.04 | FALSE |
| 11 | The Cancer Genome Atlas | Lung Adenocarcinoma | MS4A4A | 0.04 | 0.04 | enet | 7 | 0.04 | 1.1e-05 | 5.8 | 5.3 | 1.4e-07 | -0.40 | 0.66 | 0.02 | FALSE |
| 12 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | MS4A6A | 0.05 | 0.01 | enet | 10 | 0.03 | 6.6e-03 | 6.9 | 5.9 | 4.6e-09 | -0.55 | 0.03 | 0.22 | FALSE |
| 13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MS4A2 | 0.04 | 0.02 | lasso | 2 | 0.02 | 1.3e-03 | -7.2 | -7.2 | 5.8e-13 | 0.84 | 0.02 | 0.88 | FALSE |
| 14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MS4A4A | 0.07 | 0.03 | blup | 79 | 0.04 | 2.8e-05 | 6.9 | 6.8 | 1.0e-11 | -0.57 | 0.74 | 0.25 | FALSE |
| 15 | The Cancer Genome Atlas | Stomach Adenocarcinoma | MS4A2 | 0.04 | 0.04 | blup | 55 | 0.04 | 8.2e-04 | -7.1 | -7.7 | 1.2e-14 | 0.86 | 0.01 | 0.97 | TRUE |
| 16 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | MS4A4A | 0.16 | 0.02 | blup | 78 | 0.03 | 2.7e-02 | 6.9 | 5.7 | 9.4e-09 | -0.68 | 0.02 | 0.28 | FALSE |