TWAS hub - MS4A2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Kidney Renal Clear Cell Carcinoma	0.0510	0.0270	0.00019	0.030	0.026	0.015	NA	0.027	0.00023	0.00062	0.0079	NA	0.00041
2	TCGA	Prostate Adenocarcinoma	0.0364	0.0229	0.00510	0.023	0.016	0.021	NA	0.024	0.00170	0.00760	0.0023	NA	0.00130
3	TCGA	Stomach Adenocarcinoma	0.0430	0.0250	0.00390	0.041	0.039	0.030	NA	0.033	0.00055	0.00082	0.0029	NA	0.00180

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Alzheimer’s Disease (including proxy)	35.2	51.1	59.4	-6.5	-7.2	-7.7
Heel T-Score	18.2	144.9	151.3	-12.2	-11.6	-12.3
Heel bone mineral density (BMD) T-score, automated (left)	12.3	28.0	32.7	-5.0	-5.1	-5.7
Heel bone mineral density (BMD) T-score, automated (right)	10.9	25.1	28.8	-4.8	-4.9	-5.4
Alzheimer’s Disease (in mother)	9.1	10.7	12.4	-3.3	-3.0	-3.5
Chronic bronchitis/emphysema (mother)	7.9	9.1	9.9	3.2	2.8	3.1
Ever used hormone-replacement therapy (HRT)	5.9	7.5	9.1	-2.2	-3.0	-2.9
Alzheimer’s Disease (in father)	5.4	5.9	7.3	-2.1	-2.5	-2.7
Chronic bronchitis/emphysema (father)	4.8	5.6	6.4	2.1	2.5	2.5
Triglycerides	4.3	7.1	8.7	-3.0	-2.2	-2.7
Blood White Count	4.0	29.9	30.9	-5.6	-5.3	-5.5
Eye problems/disorders: Diabetes related eye disease	3.8	4.2	6.0	-1.1	-2.3	-2.5
Medication: Ibuprofen	3.8	4.6	5.7	1.9	2.4	2.1
Maternal smoking around birth	3.7	5.3	6.1	2.1	2.5	2.3
Pain all over the body in last month	3.6	3.9	5.7	2.4	1.6	1.8
Hair/balding pattern: Pattern 2	3.4	4.4	5.6	-2.4	-2.0	-1.8
Number of operations (self-reported)	3.3	4.8	7.0	-2.6	-1.9	-1.9
Diabetes (self-reported)	3.1	4.7	5.0	-2.1	-2.2	-2.2
Leg pain on walking	2.9	3.7	5.6	-2.4	-1.7	-1.6
Major Depression (MDD)	2.8	3.4	4.3	1.6	2.1	1.8
Bilateral oophorectomy (both ovaries removed)	2.8	3.2	3.5	-1.9	-1.8	-1.7
Supplements: Calcium	2.8	3.1	4.8	0.2	2.2	2.1
Hearing difficulty/problems: Yes	2.7	4.1	4.8	-2.2	-2.0	-1.9
Medication: Ibuprofen (e.g. Nurofen)	2.7	3.4	4.4	1.6	2.1	1.8
Leg fat percentage (right)	2.7	9.8	11.8	-2.6	-3.3	-3.4
Number of children fathered	2.7	3.0	3.3	1.8	1.7	1.7
Forced expiratory volume in 1-second (FEV1)	2.6	8.7	9.2	2.9	3.0	3.0
Hypothyroidism/myxoedema (self-reported)	2.6	5.0	5.4	-2.3	-2.3	-2.1
Diabetes diagnosed by doctor	2.6	4.2	4.7	-1.8	-2.2	-2.1
Forced expiratory volume in 1-second (FEV1), predicted	2.5	5.1	6.4	1.8	2.5	2.4
Mineral and other dietary supplements	2.5	3.3	4.8	-1.2	-2.2	-1.9
Forced expiratory volume in 1-second (FEV1), Best measure	2.4	7.7	7.8	2.8	2.8	2.8
Smoking status: Current	2.4	3.8	4.2	-1.9	-2.0	-1.8
Ever had prostate specific antigen (PSA) test	2.4	2.8	3.2	1.8	1.6	1.6
Myopia	2.3	3.3	4.6	1.2	1.9	2.2
Arm fat percentage (right)	2.2	8.8	10.4	-2.6	-3.0	-3.2
Heart disease (siblings)	2.2	2.7	3.7	1.3	1.7	1.9
Medication: Ventolin 100micrograms inhaler	2.1	2.7	3.2	1.8	1.5	1.6
Body fat percentage	2.1	8.3	9.8	-2.6	-2.9	-3.1
Leg fat mass (right)	2.1	8.0	9.9	-2.4	-2.9	-3.1
Illness, injury, bereavement, stress in last 2 years	2.1	2.6	3.1	-1.3	-1.8	-1.7
Supplements: Vitamin C	2.1	2.5	4.7	-2.2	-1.2	-1.1
Leg fat percentage (left)	2.1	7.8	9.7	-2.3	-2.9	-3.1
Type 2 Diabetes (T2D) (2012)	2.0	2.3	3.2	-1.2	-1.5	-1.8
Current tobacco smoking	2.0	3.3	3.8	-1.9	-2.0	-1.6
High blood pressure (mother)	2.0	2.8	3.3	1.8	1.7	1.5
Forced vital capacity (FVC)	2.0	7.6	8.3	2.7	2.6	2.9
Forced vital capacity (FVC), Best measure	2.0	7.2	7.5	2.7	2.6	2.7
Shortness of breath walking on level ground	2.0	2.3	3.8	-1.9	-1.2	-1.3
Medication: Metformin	1.9	2.6	3.7	-1.1	-1.9	-1.7
Trunk fat percentage	1.9	7.5	8.5	-2.6	-2.6	-2.9
Taking other prescription medications	1.9	2.9	3.2	-1.7	-1.8	-1.6
Waist circumference	1.9	6.9	8.5	-2.3	-2.6	-2.9
Illnesses of mother	1.9	2.3	2.8	-1.7	-1.5	-1.4
Heart disease (mother)	1.9	2.3	2.5	1.4	1.6	1.5
Arm fat percentage (left)	1.9	7.6	9.7	-2.3	-2.8	-3.1
Supplements: Fish oil (including cod liver oil)	1.8	2.4	2.9	1.5	1.7	1.4
Smoking Status	1.7	4.0	4.2	-2.0	-2.0	-1.9
Respiratory disease	1.7	3.7	4.4	1.7	2.0	2.1
Medication: Lansoprazole	1.7	2.0	3.5	-0.1	-1.9	-1.6
Ever had bowel cancer screening	1.7	2.0	3.0	1.7	1.3	1.2
Average weekly beer plus cider intake	1.7	2.5	2.8	1.7	1.5	1.6
Leg fat mass (left)	1.7	6.5	8.0	-2.2	-2.6	-2.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.5	2.8	-1.4	-1.6	-1.7
Peak expiratory flow (PEF)	1.6	3.8	4.2	2.0	1.8	2.0
Overall health rating	1.6	3.5	3.8	-1.7	-1.9	-1.9
Medication: Aspirin	1.6	2.0	2.4	-1.4	-1.5	-1.3
Tinnitus: Yes, now most or all of the time	1.6	1.9	2.2	-1.5	-1.3	-1.4
Body mass index (BMI)	1.5	6.4	8.6	-2.0	-2.5	-2.9
Age at last live birth	1.5	2.2	4.2	2.1	1.1	1.1
Medication: Aspirin	1.5	2.0	2.4	-1.3	-1.6	-1.4
Qualifications: nursing, teaching	1.5	2.3	3.2	-1.0	-1.7	-1.8
Trunk fat mass	1.4	5.8	6.7	-2.3	-2.3	-2.6
Whole body fat mass	1.4	5.9	7.2	-2.2	-2.4	-2.7
Commuting to job workplace: Cycle	1.4	1.6	2.1	1.2	1.4	1.2
Crohns Disease (2012)	1.3	2.0	3.0	-0.6	-1.7	-1.7
Rheumatoid Arthritis	1.3	1.8	2.5	0.9	1.5	1.6
BMI	1.3	7.4	9.3	-2.3	-2.7	-3.0
Illnesses of siblings	1.3	1.8	2.2	1.2	1.5	1.3
Arm fat mass (right)	1.3	5.4	6.5	-2.1	-2.3	-2.5
Birth weight	1.3	2.7	3.8	-0.9	-1.9	-2.0
High blood pressure (siblings)	1.3	1.9	2.6	-0.8	-1.6	-1.6
Had major operations	1.3	1.5	2.2	-1.5	-1.1	-1.0
Loneliness, isolation	1.3	1.8	4.6	2.1	0.8	0.5
Alcohol drinker status: Never	1.3	1.6	2.2	0.9	1.5	1.3
Ever smoked	1.3	2.3	3.4	-1.8	-1.6	-1.1
Hypothyroidism (self reported)	1.2	2.8	3.3	-1.8	-1.6	-1.5
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	2.1	1.4	1.0	1.1
Had other major operations	1.2	1.5	2.4	-1.5	-0.9	-1.1
Medication: Cholesterol lowering	1.2	1.8	2.1	-1.2	-1.3	-1.5
Lung cancer (father)	1.2	1.4	1.9	0.7	1.4	1.3
Alcohol drinker status: Previous	1.2	1.4	1.8	-1.1	-1.3	-1.1
Schizophrenia vs Biploar Disorder	1.1	1.5	1.7	-1.3	-1.0	-1.3
Breast Cancer	1.1	2.6	2.9	1.7	1.6	1.5
Comparative body size at age 10	1.1	3.1	4.3	-1.0	-2.0	-2.1
Health satisfaction	1.1	1.4	2.7	-1.7	-0.9	-0.8
Arm fat mass (left)	1.1	4.7	6.0	-1.9	-2.1	-2.4
Systolic blood pressure, automated reading	1.0	2.9	3.5	-1.6	-1.9	-1.6
Medication for hormone replacement therapy	1.0	1.1	1.6	-1.3	-1.0	-0.9
Financial difficulties in last 2 years	1.0	1.3	1.6	0.9	1.2	1.3
Medication: Simvastatin	1.0	1.5	2.4	-1.5	-1.0	-1.1
Asthma	1.0	2.0	3.5	1.0	1.2	1.9
Ever had hysterectomy (womb removed)	0.9	1.0	1.9	-1.4	-0.6	-0.8
Pack years adult smoking proportion	0.9	1.4	2.5	-1.6	-1.0	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	1.4	-1.1	-1.2	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	1.5	-0.4	-1.2	-1.2
Commuting to job workplace: Walk	0.9	1.0	1.5	-0.4	-1.1	-1.2
Medication: Paracetamol	0.9	1.3	2.3	1.5	1.1	0.7
Pack years of smoking	0.9	1.4	2.4	-1.6	-1.0	-0.8
Age at First Birth	0.8	1.2	2.4	0.1	-1.1	-1.6
Bipolar Disorder (2011)	0.8	0.8	1.4	-1.0	0.0	-1.2
HDL Cholesterol	0.8	1.3	1.8	1.1	0.9	1.3
Lupus	0.8	1.2	2.8	-1.7	-0.8	-0.5
Townsend deprivation index at recruitment	0.8	1.2	1.9	-0.0	1.4	1.3
Medication: Levothyroxine sodium	0.8	1.4	1.6	-1.2	-1.3	-1.1
Allergy	0.8	1.9	3.1	-0.8	-1.4	-1.8
Medication: Paracetamol	0.8	1.4	2.1	1.2	1.5	0.8
Mean time to correctly identify matches	0.8	1.6	2.4	0.5	-1.4	-1.5
Eye problems/disorders: Cataract	0.8	0.9	1.5	1.2	0.6	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.2	1.5	0.6	0.7
Pain type(s) experienced in last month: Hip pain	0.8	1.0	1.6	0.6	0.9	1.3
Fractured/broken bones in last 5 years	0.8	1.0	2.3	1.5	0.4	0.7
Diastolic blood pressure, automated reading	0.8	2.5	3.2	-1.1	-1.8	-1.8
Number of treatments/medications taken	0.7	1.3	1.9	-0.7	-1.2	-1.4
Average weekly spirits intake	0.7	0.9	1.0	-1.0	-0.8	-0.9
Vitamin and mineral supplements	0.7	0.9	1.9	1.4	0.6	0.7
Had menopause	0.7	0.9	1.3	-1.1	-0.9	-0.8
Depression (self-reported)	0.7	0.9	1.6	-0.7	-1.2	-0.8
Standing height	0.7	6.7	9.4	1.5	2.9	3.1
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	1.3	1.0	1.1	1.1
Angina (self-reported)	0.7	0.9	1.3	0.4	1.1	1.1
Average weekly red wine intake	0.7	1.0	1.1	-1.0	-0.9	-1.0
Fasting Glucose	0.6	0.7	1.0	-1.0	-0.7	-0.8
Primary Biliary Cirrhosis	0.6	0.8	1.4	-1.2	-0.9	-0.5
Blood Platelet Count	0.6	6.5	9.2	-1.7	-2.7	-3.0
Diabetes (mother)	0.6	0.7	1.7	-1.3	-0.4	-0.5
Age when periods started (menarche)	0.6	1.4	1.7	-1.1	-1.2	-1.3
Qualifications: CSEs or equivalent	0.6	0.9	1.6	0.4	0.9	1.2
Hip circumference	0.6	2.4	3.1	-1.6	-1.3	-1.8
Pulse wave reflection index	0.6	0.7	0.8	-0.8	-0.9	-0.9
Ever taken oral contraceptive pill	0.6	0.7	1.0	-1.0	-0.6	-0.9
Illnesses of father: High blood pressure	0.6	0.7	1.1	0.5	1.1	0.9
Bipolar Disorder or Schizophrenia	0.5	1.1	1.6	0.6	1.3	1.2
Schizophrenia (2018)	0.5	1.1	1.6	0.7	1.3	1.0
Reaction Time	0.5	0.9	1.3	1.0	-0.6	-1.1
Schizophrenia (2014)	0.5	1.0	1.6	0.6	1.3	1.1
Blood Red Count	0.5	4.6	7.5	1.6	1.9	2.7
Lung FEV1/FVC ratio	0.5	2.5	3.2	1.3	1.8	1.5
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.8	1.4	0.3	0.3
Angina	0.5	0.6	0.9	0.3	0.9	0.9
Medication: Co-codamol	0.5	0.6	1.0	-1.0	-0.7	-0.5
Diabetes (father)	0.5	0.7	1.1	-0.7	0.7	1.0
Relative age voice broke	0.5	0.8	1.1	-1.0	-1.0	-0.5
Happiness	0.5	0.6	1.3	1.1	0.6	0.3
Noisy workplace	0.5	0.6	1.7	-1.3	-0.2	-0.2
Chest pain or discomfort	0.5	0.8	1.4	-0.6	-1.2	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.7	0.7	0.7	0.8	0.9
Asthma (self-reported)	0.5	1.0	1.9	0.7	0.7	1.4
Average weekly champagne plus white wine intake	0.5	0.7	1.0	-0.5	-0.9	-1.0
Guilty feelings	0.5	0.7	0.8	0.8	0.9	0.9
Height	0.4	8.3	12.4	1.5	3.2	3.5
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.0	0.7	0.9	1.0
Past tobacco smoking	0.4	0.8	1.0	1.0	1.0	0.7
Hearing difficulty/problems with background noise	0.4	0.6	0.7	-0.7	-0.9	-0.8
Father’s age at death	0.4	0.5	0.6	-0.8	-0.6	-0.7
Breastfed as a baby	0.4	0.5	1.3	1.1	0.5	0.2
Wheeze or whistling in the chest in last year	0.4	0.8	1.1	-0.8	-1.0	-0.8
Illnesses of siblings: Diabetes	0.4	0.4	0.6	-0.8	-0.7	-0.5
Breast cancer (self-reported)	0.4	0.5	0.8	0.4	0.9	0.7
Hearing aid user	0.4	0.5	0.6	-0.8	-0.6	-0.7
Medication: Atorvastatin	0.4	0.5	0.9	0.5	-0.5	-1.0
Basal cell carcinoma (self-reported)	0.4	0.4	0.5	0.5	0.7	0.7
Worry (Nagel 2018)	0.3	0.6	1.1	1.1	0.6	0.7
Mean Putamen Volume	0.3	0.3	0.5	-0.7	-0.5	-0.5
Type 2 Diabetes (T2D) (2018)	0.3	0.5	0.9	-1.0	-0.6	-0.5
Lung FVC	0.3	1.6	2.0	1.4	1.1	1.3
Supplements: Zinc	0.3	0.4	0.8	-0.9	0.5	0.2
Average weekly fortified wine intake	0.3	0.3	0.5	-0.4	0.6	0.7
Supplements: Glucosamine	0.3	0.3	0.7	-0.8	-0.0	-0.6
Sitting height	0.3	2.0	2.7	1.0	1.6	1.5
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.2	1.1	0.3	0.0
Heart attack	0.3	0.4	0.8	0.4	0.6	0.9
Weight	0.3	1.4	1.7	-1.2	-1.0	-1.3
Worrier / anxious feelings	0.3	0.5	0.8	0.1	-0.8	-0.9
Number of live births	0.3	0.5	0.9	-0.0	0.7	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.5	-0.7	-0.3	-0.6
Tense / ‘highly strung’	0.3	0.4	1.2	1.1	0.3	0.0
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	0.6	0.8	0.4	0.7
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.6	0.6	0.8	0.5
Number of full brothers	0.3	0.4	0.6	0.8	0.5	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.7	0.3	0.6	0.8
Migraine (self-reported)	0.3	0.3	0.6	0.4	0.7	0.5
Pulse rate, automated reading	0.3	1.0	1.3	-0.9	-1.1	-1.1
Illnesses of father: Heart disease	0.3	0.4	0.6	-0.1	-0.8	-0.8
Mood swings	0.3	0.5	0.7	0.1	-0.9	-0.8
Friendships satisfaction	0.3	0.3	0.5	-0.1	-0.7	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.6	0.7	0.7	0.5
Back pain experienced in last month	0.3	0.4	1.0	1.0	0.5	0.2
Osteoarthritis (self-reported)	0.3	0.4	0.6	-0.1	-0.7	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.8	1.4	0.3	0.5
Mother’s age at death	0.3	0.4	1.1	-1.1	0.1	0.0
Irritability	0.3	0.5	0.8	0.1	-0.9	-0.8
Ever depressed for a whole week	0.3	0.3	0.4	0.6	0.7	0.3
Unable to work because of sickness or disability	0.3	0.4	0.4	-0.6	-0.6	-0.6
Cholesterol lowering medication	0.3	0.4	0.5	0.6	0.7	0.6
Heart attack/myocardial infarction (self-reported)	0.3	0.3	0.5	0.3	0.6	0.7
Depressed Affect (Nagel 2018)	0.2	0.5	0.9	0.1	-0.9	-0.8
Depression (Nagel 2018)	0.2	0.3	0.5	0.7	-0.5	-0.4
Ovarian Cancer	0.2	0.2	0.4	0.7	-0.5	-0.2
Neuroticism (2016)	0.2	0.3	0.5	0.1	0.6	0.7
Allergy or Eczema	0.2	0.5	0.8	0.1	0.9	0.9
Sensitivity / hurt feelings	0.2	0.4	0.7	0.8	0.5	0.5
Severe depression (siblings)	0.2	0.3	0.6	-0.1	0.4	0.8
Hand grip strength (right)	0.2	0.6	1.0	0.2	0.9	1.0
Fed-up feelings	0.2	0.3	0.7	0.8	-0.1	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.4	0.1	-0.5	-0.6
Serious illness, injury or assault to yourself	0.2	0.2	0.4	0.0	0.6	0.6
Multivitamins +/- minerals	0.2	0.3	0.9	-0.9	0.0	0.1
Neuroticism score	0.2	0.4	1.0	1.0	0.1	-0.0
Time employed in main current job	0.2	0.3	0.4	0.6	0.6	0.3
Falls in the last year	0.2	0.2	0.4	-0.5	0.6	0.3
Mouth/teeth dental problems: Dentures	0.2	0.3	0.5	0.7	0.3	0.6
Impedance of arm (left)	0.2	0.8	1.5	0.1	1.0	1.2
Length of working week for main job	0.2	0.3	0.7	-0.8	0.0	-0.3
Hair/balding pattern: Pattern 4	0.2	0.4	0.7	-0.9	-0.3	-0.7
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.3	0.6	0.4	0.4
Loud music exposure frequency	0.2	0.2	0.4	-0.2	0.5	0.6
Headache pain in last month	0.2	0.4	0.6	0.2	0.8	0.7
Worry too long after embarrassment	0.2	0.3	0.4	0.3	0.6	0.6
Age at first live birth	0.2	0.4	0.8	0.9	-0.3	-0.6
Eye problems/disorders: None of the above	0.2	0.2	0.5	-0.7	0.0	-0.4
Emphysema/chronic bronchitis	0.2	0.2	0.3	-0.4	0.4	0.5
Number of full sisters	0.2	0.3	0.7	0.9	-0.1	-0.3
Hypertension (Self-reported)	0.2	0.5	0.6	-0.7	-0.7	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.3	-0.2	0.4	0.6
Medication: Gliclazide	0.2	0.2	0.2	-0.5	-0.4	-0.5
Miserableness	0.2	0.3	0.8	0.9	0.3	0.0
Wears glasses or contact lenses	0.2	0.2	0.6	0.8	0.1	-0.2
Medication: Blood pressure	0.2	0.3	0.5	-0.2	-0.6	-0.7
High cholesterol (Self-reported)	0.2	0.3	0.5	-0.6	-0.4	-0.7
Medication: Bendroflumethiazide	0.2	0.3	0.6	-0.2	-0.6	-0.8
Medication: Lisinopril	0.2	0.3	0.5	-0.1	0.7	0.7
Risk taking	0.2	0.3	0.5	-0.4	0.4	0.7
Bipolar Disorder (2018)	0.1	0.2	0.4	0.0	0.5	0.6
Irritable Bowel Disease (IBD)	0.1	0.1	0.3	-0.1	-0.2	-0.6
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.5	0.1	0.7	0.6
Prostate Cancer	0.1	0.1	0.4	0.6	0.0	0.1
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	-0.4	-0.4	-0.2
HbA1C	0.1	0.1	0.3	-0.6	0.0	0.2
Blood Eosinophil Count	0.1	0.5	0.9	-0.9	-0.4	-0.6
Waist Hip Ratio (WHR)	0.1	0.3	0.6	-0.1	-0.8	-0.5
Neuroticism	0.1	0.3	0.8	0.9	-0.3	-0.2
Chronotype (morning person)	0.1	0.3	0.4	0.3	0.6	0.6
Hand grip strength (left)	0.1	0.3	0.5	0.0	0.7	0.6
High blood pressure	0.1	0.3	0.3	-0.5	-0.5	-0.5
Stomach or abdominal pain in last month	0.1	0.2	0.2	-0.5	-0.4	-0.3
Nervous feelings	0.1	0.2	0.5	0.7	0.1	0.0
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.3	-0.5	0.1	-0.0
Mouth/teeth dental problems	0.1	0.2	0.3	-0.5	-0.5	-0.2
Medication: Ramipril	0.1	0.1	0.2	-0.4	0.1	0.3
Fluid intelligence score	0.1	0.2	0.2	-0.4	-0.3	-0.4
Impedance of arm (right)	0.1	0.4	0.7	-0.8	0.2	0.7
Trunk fat-free mass	0.1	0.5	0.8	0.4	0.9	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.3	0.6	-0.1	0.1
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	-0.2	-0.3	-0.4
Pulse rate	0.1	0.2	0.4	-0.3	-0.6	-0.5
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.7	0.8	0.2	0.2
Prospective memory result	0.1	0.1	0.4	-0.7	0.0	-0.0
Trunk predicted mass	0.1	0.7	1.0	0.5	1.0	0.9
Birth weight of first child	0.1	0.2	0.6	-0.8	-0.1	0.2
Glaucoma (self-reported)	0.1	0.1	0.2	-0.1	0.0	0.5
Gout (self-reported)	0.1	0.2	0.2	0.5	-0.4	-0.3
Medication: Amlodipine	0.1	0.2	0.3	-0.5	-0.2	-0.5
Qualifications: College or University degree	0.1	0.2	0.3	-0.4	-0.3	-0.5
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.3	0.6	-0.1	-0.3
Medication for pain relief, constipation, heartburn	0.1	0.1	0.2	-0.3	-0.4	-0.0
Neck or shoulder pain in last month	0.1	0.2	0.4	-0.6	-0.2	0.0
Medication: Omeprazole	0.1	0.1	0.2	0.1	0.5	0.4
Medication: Seretide 50 evohaler	0.1	0.1	0.3	0.5	-0.2	-0.3
Comparative height size at age 10	0.1	0.6	1.3	-1.2	-0.1	-0.6
Suffer from ‘nerves’	0.1	0.1	0.2	0.2	0.4	0.4
Family relationship satisfaction	0.1	0.1	0.3	0.5	-0.1	-0.2
Knee pain experienced in last month	0.1	0.2	0.2	-0.3	-0.5	-0.4
Whole body fat-free mass	0.1	0.3	0.5	0.3	0.7	0.5
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	0.2	0.5	0.4
Medication for cholesterol	0.1	0.2	0.2	0.5	0.4	0.4
Osteoporosis (self-reported)	0.1	0.1	0.2	-0.5	0.2	0.3
Illnesses of father: None of the above (group 1)	0.1	0.1	0.2	-0.2	-0.4	-0.2
Whole body water mass	0.1	0.3	0.5	0.3	0.7	0.6
Financial situation satisfaction	0.1	0.2	0.3	-0.1	0.6	0.4
Eye problems/disorders: Glaucoma	0.1	0.1	0.3	-0.1	0.2	0.6
Age started oral contraceptive pill	0.1	0.2	0.3	-0.3	-0.5	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.1	0.0	0.3	0.3
Impedance of whole body	0.1	0.4	0.8	-0.2	0.6	0.9
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.1	-0.2	0.3	-0.3
Neuroticism (Nagel 2018)	0.0	0.1	0.2	0.4	-0.2	-0.1
Crohns Disease (2017)	0.0	0.1	0.1	0.4	0.1	-0.2
Ulcerative Colitis (UC)	0.0	0.1	0.2	-0.4	-0.2	-0.3
Coronary Artery Disease (CAD)	0.0	0.0	0.1	-0.2	0.0	0.1
LDL Cholesterol	0.0	0.0	0.0	-0.1	-0.1	-0.2
Ulcerative Colitis	0.0	0.0	0.0	0.1	-0.1	0.2
Systolic Blood Pressure	0.0	0.2	0.4	-0.6	-0.3	-0.1
Cardiovascular Disease	0.0	0.0	0.0	0.0	0.2	-0.1
Hair Pigment	0.0	0.1	0.3	-0.6	-0.1	0.1
Tanning	0.0	0.6	0.6	0.8	0.7	0.8
Relative age of first facial hair	0.0	0.0	0.1	0.1	-0.2	0.2
Other serious medical condition/disability diagnosed by doctor	0.0	0.1	0.1	0.3	-0.0	-0.3
Impedance of leg (right)	0.0	0.2	0.5	-0.7	-0.4	-0.1
Leg fat-free mass (left)	0.0	0.0	0.1	-0.2	0.1	-0.1
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.1	0.0	-0.0	-0.3
Medication: Atenolol	0.0	0.0	0.1	-0.2	-0.1	-0.2
Impedance of leg (left)	0.0	0.1	0.2	-0.1	0.2	0.4
Leg predicted mass (left)	0.0	0.0	0.1	-0.1	0.3	0.1
Number of incorrect matches in round	0.0	0.0	0.0	-0.1	-0.2	-0.0
Alcohol usually taken with meals	0.0	0.0	0.0	0.1	0.0	-0.1
Qualifications: None of the above	0.0	0.1	0.1	0.4	0.2	0.2
Hayfever/allergic rhinitis (self-reported)	0.0	0.1	0.1	-0.4	-0.1	-0.2
Alcohol intake versus 10 years previously	0.0	0.1	0.1	-0.3	0.3	0.1
Pulse wave Arterial Stiffness index	0.0	0.0	0.1	-0.0	0.2	0.2
Exposure to tobacco smoke at home	0.0	0.0	0.0	0.1	0.2	0.1
Blood clot in the leg (DVT)	0.0	0.0	0.0	0.1	0.0	-0.1
Arm fat-free mass (right)	0.0	0.1	0.2	0.3	0.5	0.1
Exposure to tobacco smoke outside home	0.0	0.0	0.1	0.2	0.0	-0.2
Pulse wave peak to peak time	0.0	0.0	0.0	0.2	-0.1	-0.1
Medication: Blood pressure	0.0	0.0	0.0	-0.1	-0.2	-0.1
Medication: Allopurinol	0.0	0.0	0.1	0.0	-0.3	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.0	0.1	0.2	0.1
Arm predicted mass (right)	0.0	0.1	0.3	0.4	0.5	0.2
Alcohol intake frequency.	0.0	0.0	0.1	-0.3	0.0	-0.2
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.0	0.0	-0.0	-0.2
Smoking status: Previous	0.0	0.1	0.2	-0.4	0.0	0.2
Leg fat-free mass (right)	0.0	0.3	0.5	0.2	0.7	0.5
Long-standing illness, disability or infirmity	0.0	0.1	0.1	0.2	0.3	0.2
Leg predicted mass (right)	0.0	0.2	0.4	0.2	0.6	0.4
Number of self-reported non-cancer illnesses	0.0	0.0	0.0	0.2	-0.0	0.1
Commuting to job workplace: Public transport	0.0	0.0	0.0	-0.2	-0.1	0.1
Basal metabolic rate	0.0	0.0	0.1	-0.2	0.3	0.1
Arm fat-free mass (left)	0.0	0.1	0.1	0.1	0.4	0.2
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.2	0.4	-0.1	-0.1
Pain experienced in last month	0.0	0.0	0.1	-0.3	0.1	0.1
Deep venous thrombosis (DVT) (self-reported)	0.0	0.0	0.0	0.1	0.0	-0.1
Arm predicted mass (left)	0.0	0.0	0.1	-0.1	0.2	0.1

Hub : Genes

MS4A2

Models

Trait associations