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chr2:60,466,491-62,123,953

Best TWAS P=2.55e-11 · Best GWAS P=1.21e-09 conditioned to 0.00945

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	AHSA2	0.41	0.31	enet	27	0.41	2.2e-53	4.7	-5.3	1.3e-07	-0.32	0.93	0.06	FALSE
2	CommonMind	Brain Pre-frontal Cortex	KIAA1841	0.05	0.05	enet	15	0.06	1.2e-07	-4.0	-5.1	3.0e-07	-0.26	0.96	0.04	FALSE
3	CommonMind	Brain Pre-frontal Cortex	PUS10	0.22	0.15	bslmm	364	0.16	6.7e-19	-4.4	-5.2	1.5e-07	-0.40	0.98	0.02	FALSE
4	GTEx	Adipose Subcutaneous	AC016747.3	0.21	0.27	lasso	5	0.26	1.1e-21	4.7	-5.2	2.6e-07	-0.28	0.94	0.06	FALSE
5	GTEx	Adipose Visceral Omentum	AC016747.3	0.14	0.13	enet	15	0.16	7.6e-09	4.4	-6.0	2.3e-09	-0.33	0.96	0.04	FALSE
6	GTEx	Brain Caudate basal ganglia	AHSA2	0.32	0.29	enet	18	0.34	1.4e-10	4.5	-5.2	1.9e-07	-0.22	0.93	0.04	FALSE
7	GTEx	Brain Cerebellar Hemisphere	AHSA2	0.35	0.22	enet	12	0.38	7.8e-11	-4.6	-5.5	4.1e-08	-0.26	0.89	0.05	FALSE
8	GTEx	Brain Cerebellum	KIAA1841	0.10	0.05	lasso	3	0.05	1.2e-02	-5.3	-5.2	1.8e-07	-0.25	0.27	0.12	FALSE
9	GTEx	Brain Cortex	AHSA2	0.25	0.13	enet	13	0.23	5.8e-07	4.8	-5.9	4.2e-09	-0.31	0.70	0.10	FALSE
10	GTEx	Brain Hippocampus	AHSA2	0.34	0.40	enet	17	0.35	5.9e-09	4.6	-5.5	4.5e-08	-0.28	0.90	0.05	FALSE
11	GTEx	Brain Nucleus accumbens basal ganglia	KIAA1841	0.17	0.16	lasso	3	0.18	1.7e-05	-4.8	-5.3	1.3e-07	-0.36	0.37	0.09	FALSE
12	GTEx	Brain Nucleus accumbens basal ganglia	AHSA2	0.44	0.34	enet	13	0.39	1.7e-11	3.8	-5.2	1.7e-07	-0.28	0.94	0.04	FALSE
13	GTEx	Brain Putamen basal ganglia	AHSA2	0.32	0.39	enet	14	0.36	2.6e-09	3.8	-5.5	4.3e-08	-0.28	0.92	0.04	FALSE
14	GTEx	Breast Mammary Tissue (Female)	AC016747.3	0.18	0.13	enet	9	0.10	8.4e-04	4.7	-5.3	1.3e-07	-0.36	0.45	0.22	FALSE
15	GTEx	Cells Transformed fibroblasts	AHSA2	0.32	0.33	enet	16	0.36	1.2e-27	4.7	-5.3	1.4e-07	-0.37	0.93	0.07	FALSE
16	GTEx	Colon Transverse	AHSA2	0.24	0.25	lasso	10	0.32	7.8e-16	4.2	-5.5	3.3e-08	-0.37	0.98	0.02	FALSE
17	GTEx	Colon Transverse	AC010733.5	0.12	0.00	lasso	6	0.00	4.5e-01	4.9	-6.7	2.5e-11	-0.60	0.05	0.40	TRUE
18	GTEx	Esophagus Gastroesophageal Junction	AHSA2	0.47	0.52	enet	25	0.59	7.0e-26	4.6	-5.1	3.0e-07	-0.31	0.96	0.04	FALSE
19	GTEx	Esophagus Muscularis	AHSA2	0.44	0.39	enet	24	0.46	7.4e-31	4.7	-5.3	1.2e-07	-0.39	0.93	0.07	FALSE
20	GTEx	Esophagus Muscularis	NONOP2	0.07	0.00	enet	31	0.01	4.8e-02	5.8	-6.1	9.8e-10	-0.61	0.04	0.68	FALSE
21	GTEx	Heart Left Ventricle	AHSA2	0.13	0.08	lasso	8	0.07	1.2e-04	4.7	-5.6	2.1e-08	-0.32	0.84	0.09	FALSE
22	GTEx	Liver	AHSA2	0.33	0.19	lasso	6	0.29	1.2e-08	4.7	-5.2	1.6e-07	-0.29	0.88	0.07	FALSE
23	GTEx	Lung	RP11-493E12.2	0.06	0.04	lasso	3	0.01	2.6e-02	5.0	5.4	5.3e-08	0.65	0.06	0.77	FALSE
24	GTEx	Muscle Skeletal	AHSA2	0.08	0.06	lasso	4	0.09	2.5e-09	4.4	-5.3	1.1e-07	-0.24	0.97	0.03	FALSE
25	GTEx	Stomach	AHSA2	0.22	0.17	enet	21	0.24	1.0e-11	4.6	-5.4	8.0e-08	-0.29	0.96	0.04	FALSE
26	GTEx	Thyroid	RP11-493E12.2	0.05	0.06	lasso	5	0.05	9.3e-05	4.2	5.3	1.0e-07	0.38	0.59	0.25	FALSE
27	GTEx	Uterus	PUS10	0.34	0.21	lasso	8	0.14	7.4e-04	-4.4	-6.0	1.9e-09	-0.48	0.07	0.28	FALSE
28	GTEx	Whole Blood	AC016747.3	0.07	0.08	lasso	6	0.08	3.9e-08	-4.7	-5.1	2.7e-07	-0.24	0.94	0.06	FALSE
29	ROSMAP	Brain Pre-frontal Cortex	PEX13	0.10	0.06	blup	330	0.10	1.7e-12	5.6	6.0	2.5e-09	0.80	0.03	0.97	FALSE
30	YFS	Blood	PEX13	0.01	0.00	blup	334	0.01	6.7e-03	-4.2	5.5	3.4e-08	0.49	0.08	0.51	FALSE
31	The Cancer Genome Atlas	Colon Adenocarcinoma	AHSA2	0.10	0.11	enet	10	0.11	4.1e-07	-4.7	-5.1	3.1e-07	-0.21	0.01	0.96	FALSE
32	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PUS10	0.04	0.00	blup	64	0.03	3.8e-04	5.8	-6.5	1.1e-10	-0.64	0.02	0.44	FALSE
33	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PEX13	0.06	0.03	lasso	3	0.04	1.3e-02	5.6	5.7	9.9e-09	0.54	0.03	0.52	FALSE
34	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	AHSA2	0.20	0.11	blup	39	0.22	3.5e-09	4.5	-5.1	2.8e-07	-0.23	0.02	0.94	FALSE
35	The Cancer Genome Atlas	Prostate Adenocarcinoma	AHSA2	0.17	0.25	blup	39	0.27	7.6e-28	4.6	-5.1	2.7e-07	-0.29	0.01	0.96	FALSE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	PUS10	0.09	0.06	blup	64	0.07	4.8e-08	-3.8	-5.5	3.9e-08	-0.47	0.98	0.02	FALSE
37	The Cancer Genome Atlas	Rectum Adenocarcinoma	C2orf74	0.44	0.28	enet	16	0.29	1.4e-07	4.8	5.2	1.7e-07	0.25	0.01	0.98	FALSE
38	The Cancer Genome Atlas	Skin Cutaneous Melanoma	PEX13	0.11	0.00	blup	40	0.03	6.6e-02	-4.4	6.4	1.3e-10	0.62	0.01	0.48	FALSE
39	The Cancer Genome Atlas	Thyroid Carcinoma	PEX13	0.03	0.03	enet	6	0.04	1.9e-04	5.0	6.0	1.8e-09	0.80	0.01	0.95	FALSE