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chr3:120,799,666-122,356,172

Best TWAS P=5.96e-17 · Best GWAS P=8.69e-17 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	SLC15A2	0.07	0.08	lasso	6	0.08	1.7e-09	5.4	-5.7	1.1e-08	0.53	0.98	0.02	FALSE
2	GTEx	Brain Cerebellar Hemisphere	SLC15A2	0.17	0.03	lasso	15	0.02	9.7e-02	-8.1	-8.4	6.0e-17	0.99	0.04	0.86	TRUE
3	GTEx	Brain Cerebellar Hemisphere	IQCB1	0.27	0.24	lasso	7	0.25	5.1e-07	-6.2	-5.9	3.0e-09	0.47	0.38	0.06	FALSE
4	GTEx	Brain Cerebellum	SLC15A2	0.33	0.47	lasso	18	0.44	1.8e-14	-8.2	-8.2	2.2e-16	1.00	0.03	0.97	FALSE
5	GTEx	Brain Frontal Cortex BA9	IQCB1	0.34	0.24	enet	48	0.22	1.7e-06	-6.0	-5.3	1.4e-07	0.48	0.27	0.41	FALSE
6	GTEx	Brain Hypothalamus	IQCB1	0.24	0.24	lasso	3	0.22	6.5e-06	-6.0	-6.0	2.1e-09	0.48	0.11	0.38	FALSE
7	GTEx	Brain Nucleus accumbens basal ganglia	IQCB1	0.37	0.24	lasso	11	0.30	1.2e-08	3.0	-5.4	6.8e-08	0.35	0.78	0.04	FALSE
8	GTEx	Breast Mammary Tissue	IQCB1	0.36	0.22	enet	23	0.33	2.3e-17	-6.0	-5.9	4.7e-09	0.47	1.00	0.00	FALSE
9	GTEx	Breast Mammary Tissue (Female)	IQCB1	0.33	0.10	lasso	11	0.22	3.1e-07	-3.3	-5.4	5.6e-08	0.48	0.25	0.62	FALSE
10	GTEx	Esophagus Muscularis	SLC15A2	0.12	0.01	enet	19	0.04	2.7e-03	-7.4	-7.7	1.4e-14	0.68	0.06	0.87	FALSE
11	GTEx	Heart Atrial Appendage	SLC15A2	0.23	0.25	lasso	14	0.24	2.3e-11	-8.3	-8.1	6.9e-16	1.00	0.03	0.97	FALSE
12	GTEx	Heart Left Ventricle	SLC15A2	0.16	0.19	lasso	6	0.20	8.6e-11	-8.1	-8.1	7.7e-16	0.99	0.03	0.97	FALSE
13	GTEx	Liver	EAF2	0.16	0.06	enet	32	0.07	5.4e-03	-7.2	-6.5	9.1e-11	0.66	0.07	0.51	FALSE
14	GTEx	Muscle Skeletal	EAF2	0.05	0.04	lasso	6	0.02	1.5e-03	-6.5	-6.7	2.8e-11	0.61	0.07	0.68	FALSE
15	GTEx	Muscle Skeletal	SLC15A2	0.11	0.05	enet	43	0.07	8.4e-08	-8.2	-6.6	3.5e-11	0.83	0.03	0.97	FALSE
16	GTEx	Nerve Tibial	SLC15A2	0.08	0.10	lasso	8	0.07	8.0e-06	-8.2	-7.8	5.6e-15	0.99	0.03	0.97	FALSE
17	GTEx	Pituitary	IQCB1	0.29	0.14	enet	19	0.24	1.1e-06	-3.3	-5.6	2.6e-08	0.49	0.22	0.50	FALSE
18	GTEx	Skin Sun Exposed Lower leg	EAF2	0.10	0.02	lasso	7	0.06	8.8e-06	-6.5	-5.2	2.6e-07	0.39	0.37	0.35	FALSE
19	GTEx	Skin Sun Exposed Lower leg	IQCB1	0.28	0.15	lasso	5	0.26	6.1e-22	-6.2	-5.4	5.5e-08	0.45	1.00	0.00	FALSE
20	GTEx	Spleen	IQCB1	0.29	0.08	enet	18	0.12	6.9e-04	-6.0	-5.7	1.1e-08	0.43	0.08	0.20	FALSE
21	GTEx	Whole Blood	IQCB1	0.14	0.04	enet	36	0.07	2.6e-07	5.1	-6.0	2.3e-09	0.53	0.98	0.02	FALSE
22	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	EAF2	0.06	0.02	enet	8	0.02	9.3e-04	3.1	-5.7	1.1e-08	0.35	0.15	0.04	FALSE
23	The Cancer Genome Atlas	Brain Lower Grade Glioma	EAF2	0.05	0.01	blup	70	0.04	3.3e-05	-8.3	-6.5	8.3e-11	0.78	0.03	0.96	FALSE
24	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IQCB1	0.17	0.06	enet	6	0.07	1.3e-08	-3.3	-5.2	1.7e-07	0.45	0.92	0.06	FALSE
25	The Cancer Genome Atlas	Rectum Adenocarcinoma	IQCB1	0.23	0.18	lasso	7	0.14	4.8e-04	-6.0	-5.7	1.3e-08	0.51	0.04	0.49	FALSE
26	The Cancer Genome Atlas	Thyroid Carcinoma	ILDR1	0.06	0.00	blup	48	0.02	3.5e-03	5.1	5.6	2.4e-08	-0.62	0.01	0.54	FALSE
27	The Cancer Genome Atlas	Thyroid Carcinoma	SLC15A2	0.06	0.04	blup	73	0.05	8.0e-06	5.1	7.5	5.7e-14	-0.80	0.10	0.88	FALSE