Hub : Genes

EAF2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0519	0.0249	9.1e-03	0.007	NA	0.014	NA	0.018	9.0e-02	NA	2.8e-02	NA	1.3e-02
2	GTEx	Cells EBV-transformed lymphocytes	0.2160	0.0690	1.4e-04	0.176	NA	0.122	NA	0.154	2.3e-06	NA	8.8e-05	NA	1.0e-05
3	GTEx	Cells Transformed fibroblasts	0.1640	0.0520	3.4e-06	0.035	NA	0.062	NA	0.074	1.2e-03	NA	2.0e-05	NA	3.2e-06
4	GTEx	Liver	0.1610	0.0700	4.1e-03	0.061	NA	0.070	NA	0.008	8.9e-03	NA	5.4e-03	NA	1.9e-01
5	GTEx	Muscle Skeletal	0.0489	0.0208	2.3e-03	0.037	NA	0.009	NA	0.025	1.5e-04	NA	4.3e-02	NA	1.6e-03
6	GTEx	Skin Sun Exposed Lower leg	0.0960	0.0330	2.9e-05	0.020	NA	0.050	NA	0.061	7.6e-03	NA	5.0e-05	NA	8.8e-06
7	NTR	Blood	0.0194	0.0074	2.9e-04	0.021	0.011	0.016	0.012	0.017	2.0e-07	1.6e-04	4.4e-06	5.4e-05	2.3e-06
8	YFS	Blood	0.0138	0.0074	1.0e-02	-0.001	0.002	-0.001	0.002	-0.001	6.4e-01	6.1e-02	7.4e-01	4.9e-02	8.9e-01
9	TCGA	Head and Neck Squamous Cell Carcinoma	0.0594	0.0375	4.1e-03	0.019	0.020	0.024	NA	0.023	2.5e-03	2.3e-03	9.2e-04	NA	1.2e-03
10	TCGA	Brain Lower Grade Glioma	0.0465	0.0244	1.3e-05	0.005	0.038	0.034	NA	0.025	7.8e-02	3.3e-05	7.8e-05	NA	6.3e-04
11	TCGA	Prostate Adenocarcinoma	0.0729	0.0341	2.5e-05	0.054	0.048	0.044	NA	0.051	2.6e-06	8.3e-06	2.2e-05	NA	4.5e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.2	0.3	0.9	0.9	0.1	0.7	0.9	0.3	-0.0	0.2	0.3	-0.0	0.3	0.5
Bipolar Disorder or Schizophrenia	0.6	1.4	3.1	-0.2	-1.4	-1.3	-1.8	-1.3	-0.8	1.2	0.1	-1.7	-1.4	-0.2
Depressed Affect (Nagel 2018)	0.4	0.8	2.9	0.7	0.8	0.1	-1.3	-0.8	-0.3	-1.2	-0.5	-0.1	-1.7	-0.7
Depression (Nagel 2018)	0.5	0.7	3.8	0.6	0.4	0.8	-0.8	0.3	0.5	-0.1	0.3	0.3	1.3	1.9
Intelligence (Savage-Jansen 2018)	1.0	3.1	5.4	-2.2	-1.8	-1.2	-2.1	-0.9	-0.7	2.1	2.0	-2.0	1.1	2.3
Neuroticism (Nagel 2018)	0.7	1.7	4.3	1.1	1.4	0.8	-1.6	-0.9	0.0	-1.9	-1.8	0.2	-2.1	-1.0
Schizophrenia (2018)	1.5	3.2	9.1	-1.0	-1.9	-2.2	-3.0	-2.0	-1.1	1.4	-0.2	-2.2	-2.1	-0.6
Schizophrenia vs Biploar Disorder	2.7	3.5	8.6	-0.8	-1.3	-1.6	-2.9	-2.1	-1.6	0.6	-1.8	-1.8	-2.9	-1.8
Worry (Nagel 2018)	0.4	0.9	3.3	0.7	1.2	1.2	-1.8	-0.7	0.2	-1.2	-1.0	0.3	-0.2	0.5
Alzheimer’s Disease (in mother)	0.7	0.8	3.8	0.5	-0.3	-0.5	-1.9	-1.2	-0.8	0.1	0.7	-0.9	-0.7	0.3
Alzheimer’s Disease (in father)	2.7	2.9	5.5	-0.7	-1.7	-1.2	-1.7	-1.9	-2.2	1.1	-1.2	-2.3	-2.4	-1.6
Alzheimer’s Disease (including proxy)	1.1	1.6	3.9	0.1	-0.6	-1.1	-2.0	-1.9	-1.8	0.2	-0.3	-1.6	-1.4	-0.5
Crohns Disease (2017)	1.2	2.6	5.0	1.2	2.1	2.1	1.5	0.9	1.1	-2.2	-1.7	1.9	1.4	-0.5
Irritable Bowel Disease (IBD)	0.7	1.6	4.7	0.9	1.9	1.1	0.8	0.4	1.4	-2.2	-1.3	1.4	0.4	-0.4
Ulcerative Colitis (UC)	0.2	0.4	1.4	0.0	0.7	-0.2	-0.1	-0.2	1.2	-1.0	-0.5	0.4	-0.6	-0.2
Major Depression (MDD)	0.5	0.6	1.9	-0.3	-1.1	-0.4	-0.8	-0.1	-0.1	1.1	0.5	-0.9	0.4	1.4
Reaction Time	1.1	2.0	4.8	-1.8	-1.4	1.9	-1.8	0.4	-0.2	1.8	1.0	-0.9	0.5	2.2
Verbal and Numeric Reasoning (VNR)	0.8	1.9	4.1	-0.8	-0.9	-1.1	-1.5	-1.6	-1.1	1.0	2.0	-1.8	1.1	1.7
Breast Cancer	0.5	1.1	3.3	-0.8	-0.9	-1.8	0.5	-1.1	-1.7	0.7	0.5	-1.5	0.0	-0.6
Ovarian Cancer	0.7	0.9	2.0	0.4	0.9	0.8	1.3	1.2	1.4	-0.5	-0.2	1.2	1.2	0.7
Prostate Cancer	0.2	0.2	0.7	0.2	-0.4	-0.9	0.4	-0.4	-0.1	0.3	-0.8	-0.7	-0.1	-0.3
Age at First Birth	0.1	0.2	0.4	-0.5	0.3	-0.4	0.4	-0.0	0.5	-0.4	-0.7	-0.1	-0.6	-0.7
Bipolar Disorder (2011)	1.0	1.0	2.6	1.1	-0.4	-1.0	-1.5	-1.6	-0.5	0.1	0.8	-1.2	-1.0	-0.6
Body Mass Index (BMI) (2010)	0.7	1.0	4.1	-2.0	-1.5	-0.7	-0.4	0.2	0.1	1.6	0.4	-0.9	-0.2	0.3
Coronary Artery Disease (CAD)	0.2	0.2	0.6	0.6	0.1	0.8	-0.6	-0.3	0.3	-0.3	0.3	0.1	-0.7	0.1
Crohns Disease (2012)	1.5	2.4	6.2	1.6	2.0	2.5	1.5	0.9	0.4	-2.1	-1.2	1.8	1.1	-0.1
Mean Putamen Volume	0.2	0.3	1.0	-0.8	-0.4	-0.1	0.1	-0.4	-1.0	0.5	0.7	-0.5	0.1	0.1
Fasting Glucose	0.2	0.3	1.1	-0.0	-0.4	-0.8	0.1	-0.4	-0.6	0.4	1.1	-0.2	-0.4	-0.2
HbA1C	0.5	0.6	2.9	1.7	1.2	0.2	0.5	-0.3	0.6	-1.0	-0.1	0.1	0.5	0.2
HDL Cholesterol	0.4	0.6	2.1	-0.1	-0.4	-1.0	-0.4	-1.5	-1.0	0.1	0.6	-1.2	-0.4	-0.1
LDL Cholesterol	1.1	1.8	3.4	-1.3	-1.4	-1.7	-0.6	-1.8	-1.3	0.8	-0.5	-1.7	-1.5	-1.2
Lupus	1.4	2.1	7.7	0.9	0.4	-1.0	-2.8	-2.2	0.3	-0.9	-1.3	-1.1	-2.1	0.6
Neuroticism (2016)	0.9	1.4	2.8	0.8	1.4	1.0	1.5	1.2	1.3	-1.4	-1.1	1.7	0.2	0.2
Primary Biliary Cirrhosis	1.5	2.1	4.6	2.1	1.6	0.1	-1.3	-1.5	0.2	-2.1	-1.3	0.1	-2.0	-1.4
Rheumatoid Arthritis	2.3	3.2	11.1	0.7	-0.2	-2.6	-2.8	-3.3	-1.1	-0.4	-0.3	-1.9	-1.9	-0.7
Schizophrenia (2014)	1.1	2.4	7.0	-0.3	-1.4	-1.5	-2.6	-1.9	-1.4	1.0	-0.5	-1.9	-2.2	-0.7
Triglycerides	2.2	3.5	8.5	-1.8	-2.9	-1.9	-1.2	-1.4	-1.9	2.7	1.1	-2.7	-1.0	-0.5
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.5	-1.5	-1.3	-0.5	0.5	0.4	-0.5	1.4	1.6	-0.4	0.6	0.2
Ulcerative Colitis	0.6	0.8	2.5	0.4	0.6	0.1	-0.4	0.1	1.2	-1.0	-1.6	0.4	-1.5	-1.1
Blood Eosinophil Count	0.5	3.9	11.5	0.3	1.6	2.4	2.6	3.4	1.9	-0.6	-2.1	2.5	1.3	-0.1
Blood Platelet Count	1.7	19.4	48.2	2.3	3.4	6.9	6.2	5.9	2.1	-1.7	-0.4	5.0	6.2	2.0
Blood Red Count	0.5	4.6	14.8	-1.9	-2.4	-1.1	-3.2	-2.1	-1.4	1.4	0.8	-2.3	-3.9	-1.2
Blood White Count	0.2	1.2	3.3	-1.8	-1.7	-0.3	0.9	-0.2	-0.3	1.6	0.2	-0.8	-0.2	-1.6
Heel T-Score	1.0	8.0	22.1	1.9	1.8	3.1	4.0	4.7	1.8	-0.9	-0.2	3.4	3.9	1.4
BMI	1.2	7.0	17.0	-3.9	-4.0	-2.0	-0.7	-2.0	-2.3	4.1	2.3	-3.0	0.0	0.8
Height	0.7	13.4	32.3	-5.3	-5.2	-2.2	-2.9	-0.7	-2.5	5.7	4.0	-3.7	0.2	3.0
Waist Hip Ratio (WHR)	0.1	0.3	1.0	0.0	-0.3	-0.8	-0.6	-0.8	0.4	-0.1	-0.3	-0.4	-1.0	-0.7
Systolic Blood Pressure	1.8	8.9	16.1	1.6	2.0	2.5	4.0	3.9	3.7	-1.6	-4.0	3.6	1.9	-2.4
Smoking Status	1.0	2.5	10.0	-3.2	-2.6	-1.3	-0.5	-0.4	0.2	2.5	0.3	-1.6	-0.2	0.1
Allergy or Eczema	7.8	20.5	44.3	-1.3	-3.3	-4.7	-6.5	-6.7	-5.2	1.7	-0.1	-5.7	-6.5	-0.7
Cardiovascular Disease	1.1	3.6	10.3	-2.2	-0.3	0.5	2.6	3.2	2.1	0.8	-2.7	1.6	1.2	-0.9
Hypothyroidism (self reported)	2.5	5.8	15.1	-2.2	-1.5	-3.9	-3.4	-2.9	-1.5	1.0	-1.0	-2.9	-3.0	0.3
Respiratory disease	3.4	7.6	17.0	-0.5	-2.2	-2.4	-4.0	-4.1	-3.3	1.5	1.0	-4.1	-3.0	0.1
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.6	-0.2	-0.2	0.5	1.1	1.3	0.9	0.3	-0.0	0.3	1.2	0.2
Lung FEV1/FVC ratio	1.2	5.9	13.8	1.0	2.1	2.7	3.2	3.5	2.7	-1.6	-1.4	3.7	1.7	-0.9
Lung FVC	0.3	1.3	5.1	0.0	0.5	1.2	0.9	2.2	1.6	-0.4	0.2	1.4	0.4	-1.4
Neuroticism	0.5	1.3	3.7	1.9	1.7	0.9	-0.9	-0.6	0.1	-1.9	-1.3	0.6	-0.6	0.1
Chronotype (morning person)	0.2	0.5	1.9	-1.1	0.1	-0.0	-0.1	1.4	1.3	0.1	0.1	0.9	0.4	0.5
Hair Pigment	0.1	2.9	8.4	2.6	2.4	0.4	1.4	-0.1	0.1	-2.9	-2.0	1.5	-0.5	-1.5
Tanning	0.0	0.3	1.6	-0.4	0.2	-0.1	-0.1	-0.4	-0.7	0.2	0.4	-0.2	0.3	1.3
Hand grip strength (left)	0.5	1.4	4.6	0.9	1.3	0.3	0.5	1.7	2.1	-1.1	-0.7	1.8	-0.1	-0.4
Number of treatments/medications taken	0.4	0.6	1.6	-1.0	-1.3	-0.9	0.3	-0.5	-0.2	1.1	-0.6	-1.1	0.3	-0.5
Average weekly spirits intake	1.3	1.6	5.0	2.2	2.1	1.0	-0.3	-0.1	-0.4	-1.8	0.5	1.0	0.8	1.2
Sensitivity / hurt feelings	1.5	2.6	6.8	1.9	2.0	1.3	-0.2	0.4	0.9	-2.4	-2.6	1.2	-1.7	-1.3
Frequency of depressed mood in last 2 weeks	1.1	1.5	3.6	1.5	1.6	1.5	0.4	0.9	0.6	-1.3	0.1	1.2	1.2	1.9
Hearing difficulty/problems: Yes	2.7	4.2	6.9	-2.5	-2.6	-2.3	-2.6	-1.4	-0.7	2.3	-1.0	-2.5	-2.3	-0.8
Relative age of first facial hair	0.6	1.2	3.5	1.1	1.8	1.0	1.0	0.3	0.9	-1.9	-0.1	1.4	0.2	-0.3
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	1.7	-1.2	-1.3	-0.9	-0.7	-0.2	-0.5	1.2	-0.0	-0.9	-0.7	-0.4
Ever used hormone-replacement therapy (HRT)	1.1	1.3	5.2	0.1	-0.2	0.6	1.5	1.6	1.4	0.8	1.0	0.3	2.3	0.7
Ever had hysterectomy (womb removed)	0.7	0.8	2.2	-1.5	-1.3	-0.3	0.5	-0.8	-0.6	1.1	1.2	-1.1	0.4	0.3
Systolic blood pressure, automated reading	1.7	4.9	11.5	0.4	1.4	2.0	3.4	2.7	2.6	-1.1	-2.4	2.6	1.7	-2.4
Eye problems/disorders: Diabetes related eye disease	1.9	2.1	5.0	-1.3	-1.0	0.5	1.5	1.9	1.3	1.7	1.5	0.2	2.2	1.6
Angina	0.6	0.8	2.3	0.9	0.6	1.5	1.4	0.4	0.1	-0.6	-0.4	0.8	1.0	-0.9
Medication for hormone replacement therapy	1.6	1.8	4.8	0.8	0.8	1.6	1.8	2.2	1.3	-0.3	0.1	1.2	2.1	0.2
Vitamin and mineral supplements	1.1	1.5	4.3	1.6	0.8	0.5	1.0	0.4	0.7	-1.0	-1.2	1.0	-1.9	-2.1
Supplements: Zinc	1.3	1.4	4.8	-0.5	-0.1	0.7	-0.7	-0.0	-0.8	0.6	2.0	-0.4	2.2	2.2
Medication: Co-codamol	0.8	1.0	2.2	0.3	1.2	1.1	0.7	0.3	1.1	-1.3	-1.5	0.9	0.3	-1.1
Medication: Metformin	0.3	0.5	1.2	-0.6	-0.5	1.1	1.0	1.1	-0.1	0.6	0.5	0.1	0.9	-0.1
Diabetes (father)	0.1	0.2	0.5	-0.1	0.1	0.7	0.5	0.5	0.2	-0.1	-0.3	0.3	0.1	-0.7
Diabetes (mother)	0.8	1.0	2.5	-1.0	-1.3	1.0	-0.3	-0.5	-1.1	1.2	1.6	-1.4	-0.3	-0.8
Severe depression (siblings)	0.4	0.4	2.8	0.1	-0.4	-0.5	-1.7	-0.0	0.7	0.4	0.4	-0.5	-0.4	0.7
Pack years adult smoking proportion	0.2	0.2	0.9	-0.5	-0.1	1.0	0.7	0.5	-0.0	0.2	0.3	0.3	0.5	-0.6
Impedance of leg (right)	0.5	2.4	5.2	1.3	1.9	0.9	1.1	1.5	2.3	-1.9	-1.8	2.1	0.3	-0.7
Leg fat-free mass (left)	1.7	9.0	20.4	-4.4	-4.3	-1.9	-1.7	-1.5	-2.6	4.5	3.2	-3.4	-0.3	1.9
Trunk fat percentage	1.3	5.2	15.0	-3.9	-3.4	-1.4	-0.7	-1.2	-0.8	3.5	2.6	-2.3	0.7	1.1
Hand grip strength (right)	0.5	1.3	4.3	0.4	1.1	0.7	0.4	1.9	2.1	-0.7	0.0	1.6	0.8	0.6
Townsend deprivation index at recruitment	1.0	1.5	5.3	-0.7	-0.1	1.5	1.4	1.8	2.3	0.3	-0.5	1.0	0.5	-1.1
Current tobacco smoking	0.9	1.5	2.3	-1.3	-1.5	-1.2	-1.5	-1.5	-0.8	1.3	0.9	-1.5	-0.9	0.0
Average weekly fortified wine intake	1.2	1.4	3.4	-0.1	-0.3	1.8	0.4	1.6	0.9	0.9	1.4	0.5	1.8	1.7
Maternal smoking around birth	0.1	0.1	0.3	0.0	-0.1	-0.2	0.3	0.2	0.4	0.2	0.1	0.4	-0.2	-0.5
Fed-up feelings	0.9	1.6	4.9	1.1	1.4	0.2	0.3	-0.2	-0.3	-1.9	-1.8	0.9	-2.2	-1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.1	0.5	0.8	1.1	0.3	0.6	0.6	-0.6	-0.3	0.7	1.0	0.7
Relative age voice broke	0.8	1.3	3.8	1.0	1.9	1.2	1.1	-0.2	0.1	-1.9	-0.4	1.2	0.8	0.3
Taking other prescription medications	0.6	0.9	2.7	-0.9	-0.7	-1.6	-1.4	-1.2	0.1	0.5	-0.5	-1.1	-0.4	0.7
Age when periods started (menarche)	0.9	2.1	5.2	2.3	2.1	0.3	0.7	1.4	1.4	-1.9	-1.3	1.8	0.6	0.1
Bilateral oophorectomy (both ovaries removed)	0.6	0.6	1.4	-0.7	-1.1	0.1	0.8	0.2	-0.3	1.2	1.1	-0.8	0.8	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.7	6.3	1.0	0.7	0.5	2.5	2.2	0.5	-0.1	1.0	1.4	1.7	0.1
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	3.8	0.7	-0.1	-0.2	-2.0	-1.6	-1.1	-0.3	-0.1	-1.0	-1.1	-0.6
Qualifications: CSEs or equivalent	1.0	1.3	3.0	0.2	1.0	1.1	1.0	1.5	1.6	-0.8	-1.7	1.4	0.3	-0.6
Serious illness, injury or assault to yourself	1.6	1.9	4.6	-1.2	-2.1	-0.9	-0.8	-1.3	-0.8	2.0	1.5	-2.0	0.0	0.9
High blood pressure	0.9	2.5	8.6	-1.3	-0.3	0.1	2.5	1.8	1.6	0.2	-2.9	1.1	0.1	-2.0
Hayfever, allergic rhinitis or eczema	6.9	15.0	35.2	-1.2	-2.9	-3.6	-5.9	-5.6	-4.2	1.7	-0.1	-4.8	-5.6	-0.7
Multivitamins +/- minerals	1.1	1.4	6.5	-1.1	0.0	1.3	0.5	1.0	0.0	0.4	1.3	0.5	2.5	1.5
Stomach or abdominal pain in last month	1.8	2.2	6.4	-0.5	-1.6	-1.7	-0.9	-2.1	-2.1	1.2	0.6	-2.5	-0.9	-0.5
Supplements: Glucosamine	0.3	0.3	0.9	0.1	0.4	-0.7	-0.3	-1.0	-0.5	-0.7	-0.5	-0.3	-0.7	-0.6
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	3.7	-0.4	-0.7	-0.3	-1.9	-0.6	-0.7	0.6	-0.8	-1.1	-1.3	0.2
Medication: Atenolol	0.9	1.1	4.7	-0.3	0.3	1.2	0.5	1.1	0.4	0.1	0.7	0.8	1.7	2.2
Medication: Levothyroxine sodium	4.1	6.9	15.5	-1.6	-1.6	-3.6	-3.7	-3.7	-1.8	0.7	-1.2	-3.0	-3.9	-0.9
Sitting height	0.8	5.9	15.6	-3.5	-3.3	-0.1	-1.0	0.6	-1.4	4.0	3.1	-1.9	1.1	3.0
Chronic bronchitis/emphysema (father)	5.1	6.0	13.0	-2.8	-3.3	-1.6	-3.6	-1.7	-2.3	2.8	1.7	-3.0	-1.7	0.1
High blood pressure (mother)	0.2	0.3	0.7	-0.3	-0.4	-0.9	-0.5	0.2	-0.5	0.7	-0.6	-0.1	0.3	0.8
Body mass index (BMI)	1.4	5.8	12.9	-3.6	-3.6	-1.9	-0.7	-1.9	-2.2	3.6	2.1	-2.9	-0.2	0.5
Impedance of leg (left)	0.4	1.9	3.3	1.5	1.7	0.8	1.1	1.3	1.8	-1.7	-1.2	1.8	0.6	-0.6
Leg predicted mass (left)	1.7	9.0	20.4	-4.4	-4.3	-1.9	-1.7	-1.5	-2.6	4.5	3.2	-3.4	-0.3	1.9
Trunk fat mass	1.8	7.6	20.7	-4.5	-4.1	-1.7	-1.1	-1.4	-1.4	4.2	3.1	-2.9	0.6	1.4
Waist circumference	2.0	7.4	18.5	-4.3	-4.1	-1.8	-1.0	-1.7	-1.7	4.2	2.8	-3.0	0.3	1.3
Number of incorrect matches in round	0.4	0.7	1.8	0.4	0.7	0.6	1.2	1.4	0.8	-0.5	-0.7	1.1	0.8	-0.1
Past tobacco smoking	1.5	2.7	8.9	3.0	2.3	0.6	0.3	-0.3	-0.9	-2.6	-1.5	1.3	-1.1	-1.4
Alcohol usually taken with meals	0.2	0.4	1.0	0.4	0.7	-0.1	-0.3	-0.7	-1.0	-0.9	-0.6	-0.1	-0.8	0.6
Nervous feelings	1.6	3.0	6.6	1.0	2.4	1.7	-0.4	1.0	2.6	-2.5	-2.0	2.1	0.8	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.7	-0.2	-0.3	0.3	-0.5	-0.4	-0.9	0.3	1.1	-0.9	0.1	1.3
Hearing difficulty/problems with background noise	1.1	1.8	6.0	-2.5	-1.7	-0.7	-1.6	-0.1	1.4	1.7	-0.4	-1.0	-1.2	0.2
Hair/balding pattern: Pattern 2	0.3	0.4	0.9	0.9	-0.0	0.2	0.9	-0.8	-0.9	-0.1	0.2	-0.2	-0.4	-0.7
Had menopause	1.0	1.2	4.4	0.5	1.0	0.0	-0.0	-0.7	0.4	-1.7	-1.5	0.2	-1.3	-2.1
Had other major operations	0.2	0.3	0.9	-0.2	-0.6	-0.5	-0.5	0.3	0.9	0.4	-0.8	-0.2	-0.3	-0.5
Forced vital capacity (FVC)	0.1	0.5	2.5	-0.1	0.0	0.8	-0.1	1.4	1.6	0.2	0.2	0.7	-0.2	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	5.7	1.3	0.8	0.9	2.4	2.2	0.2	-0.3	1.2	1.5	2.1	0.6
Ever unenthusiastic/disinterested for a whole week	6.5	7.9	14.9	-2.7	-3.7	-2.5	-1.6	-2.6	-3.4	3.2	3.1	-3.9	-2.1	0.5
Qualifications: None of the above	1.0	2.2	5.4	0.9	1.2	0.9	2.3	2.0	2.3	-0.8	0.1	1.9	1.4	0.4
Financial difficulties in last 2 years	1.0	1.4	3.0	0.6	1.1	1.6	1.7	1.4	0.6	-0.9	-1.0	1.7	1.2	0.1
Mouth/teeth dental problems	0.7	1.1	2.5	0.3	1.1	0.9	1.1	1.4	1.2	-0.8	0.5	1.3	1.6	0.1
Heart attack	0.4	0.5	2.0	-0.5	-0.7	-0.4	0.3	-0.7	-0.4	0.6	1.4	-0.4	0.3	1.1
Allergy	6.9	16.0	35.1	2.4	3.9	3.4	5.9	5.4	4.2	-3.2	-1.7	5.4	4.2	-0.9
Pain all over the body in last month	0.5	0.5	1.3	0.9	1.0	-0.4	-0.2	0.3	0.9	-1.1	-1.0	0.5	-0.2	-0.4
Diabetes (self-reported)	0.2	0.4	1.3	-0.2	-0.5	0.7	1.1	1.0	0.1	0.6	0.2	0.1	0.7	-0.0
Hayfever/allergic rhinitis (self-reported)	1.8	2.4	6.6	-1.5	-1.4	-2.1	-1.4	-1.7	-2.6	1.2	0.3	-1.8	-1.4	0.2
Medication: Ramipril	1.2	1.6	4.1	-2.0	-1.4	0.2	1.2	1.9	0.2	2.0	0.5	-0.1	1.3	0.8
Medication: Simvastatin	0.3	0.4	1.3	-1.1	-0.8	-0.3	0.7	0.6	0.5	0.9	-0.6	0.1	0.3	-0.5
Fluid intelligence score	1.3	2.6	6.8	-0.5	-1.2	-2.0	-1.7	-2.6	-1.9	1.0	0.9	-2.5	0.2	1.5
Illnesses of siblings	0.4	0.5	2.2	-0.2	-0.4	-1.0	-0.1	-0.5	-1.0	0.6	0.6	-0.7	0.1	1.5
Neuroticism score	0.7	1.4	4.1	1.6	1.9	1.5	-0.5	0.2	0.3	-2.0	-1.1	1.1	-0.5	0.3
Weight	2.2	10.8	25.7	-5.1	-4.8	-1.9	-1.4	-1.5	-2.8	5.1	3.6	-3.5	0.3	1.8
Impedance of arm (right)	1.1	5.2	11.2	2.1	2.8	2.4	1.4	2.4	3.3	-2.5	-1.6	3.1	1.2	0.2
Arm fat percentage (right)	0.6	2.4	7.4	-2.7	-2.4	-0.7	0.0	-0.7	-0.7	2.5	1.6	-1.5	0.7	0.6
Trunk fat-free mass	1.5	8.5	18.5	-4.0	-4.1	-1.8	-1.8	-1.3	-3.2	4.3	3.3	-3.2	-0.4	1.9
Hip circumference	2.4	10.2	24.5	-4.9	-4.8	-1.9	-1.3	-2.1	-2.9	4.8	2.8	-3.6	-0.5	1.4
Time employed in main current job	0.3	0.4	1.1	-1.0	0.2	-0.1	-0.1	0.7	1.0	0.2	0.6	0.0	0.7	0.8
Alcohol intake versus 10 years previously	2.0	2.9	12.0	-1.7	-0.9	-0.6	-0.7	-0.7	0.8	0.2	-2.6	-0.2	-2.7	-3.5
Father’s age at death	0.6	0.8	2.7	1.7	1.2	0.3	0.1	-0.5	-0.7	-1.5	-0.9	0.6	-0.4	0.5
Worrier / anxious feelings	0.9	1.7	4.0	1.8	1.4	0.4	-0.3	-1.1	-0.3	-1.9	-2.0	0.2	-1.7	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	1.2	0.1	-0.7	0.4	-0.1	-0.5	-0.8	0.6	-0.2	-0.8	-0.8	-1.1
Falls in the last year	1.0	1.3	2.5	-1.6	-1.6	-0.3	-1.2	-1.1	-1.3	1.4	0.0	-1.6	-0.6	0.4
Hair/balding pattern: Pattern 3	0.3	0.4	1.4	-0.4	-0.7	-0.4	-0.1	0.3	0.2	1.0	0.4	-0.6	1.2	0.5
Number of live births	1.0	1.4	2.6	1.1	1.3	1.1	1.5	0.9	0.6	-1.6	-1.5	1.4	0.0	-1.0
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	4.3	0.7	0.8	1.3	1.0	2.1	1.9	-0.5	-0.8	1.7	0.2	-0.9
Pulse rate	0.3	0.5	2.6	-0.6	-0.2	-0.7	1.6	-0.3	-0.4	0.4	0.2	-0.3	0.8	0.6
Happiness	0.4	0.5	1.7	-0.3	0.8	1.0	0.1	-0.1	0.3	-1.1	-1.3	0.3	-0.9	-0.6
Noisy workplace	0.8	0.9	4.3	1.0	0.4	0.4	0.8	1.2	0.6	-0.5	-0.8	0.7	-0.9	-2.1
Qualifications: A levels/AS levels or equivalent	0.5	1.1	3.5	0.9	0.8	0.1	-1.4	-1.4	-0.7	-1.0	-1.9	-1.0	-0.7	0.4
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	3.3	-0.5	-1.1	-0.7	-1.5	-1.6	-1.4	1.0	1.8	-1.8	-0.4	1.1
Mouth/teeth dental problems: Dentures	0.9	1.5	6.0	0.4	-0.5	0.0	-1.0	-1.2	-1.4	-0.2	-1.1	-1.0	-2.4	-1.8
Asthma	4.0	7.8	15.9	-1.9	-2.9	-2.7	-4.0	-3.6	-2.8	2.5	1.3	-4.0	-2.3	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	5.9	0.1	0.1	0.5	2.4	1.4	0.6	0.2	-1.0	0.8	1.0	-0.5
Medication: Cholesterol lowering	0.4	0.6	1.6	-0.9	-1.2	-1.2	0.3	-0.4	0.7	1.1	-0.5	-0.4	0.5	-0.1
Depression (self-reported)	0.9	1.1	2.3	-1.5	-1.2	-0.8	-1.1	-1.0	-1.0	0.8	0.3	-1.0	-1.5	-0.7
Medication: Lansoprazole	0.4	0.4	2.0	-1.3	-0.2	-0.1	1.4	0.6	-0.4	0.3	-0.5	0.3	0.2	-0.2
Prospective memory result	1.4	1.8	3.9	0.5	0.7	1.2	0.9	1.9	2.0	-0.6	-1.7	1.9	-0.2	-1.4
Lung cancer (father)	0.7	0.8	3.7	0.6	-0.8	0.2	-0.8	-0.3	0.4	1.1	1.9	-0.4	0.5	1.0
Illnesses of mother	0.6	0.7	2.9	0.3	-0.0	1.2	1.7	0.7	-0.2	0.1	1.0	0.6	0.8	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	2.2	0.2	0.3	0.8	0.6	1.3	1.5	0.0	0.1	1.0	0.5	-0.1
Pulse wave Arterial Stiffness index	1.2	1.4	4.8	-2.2	-1.3	-1.3	0.6	1.3	1.2	1.7	-0.2	-0.1	0.6	-0.0
Impedance of arm (left)	0.8	3.5	8.1	1.8	2.3	2.0	0.8	2.0	2.9	-2.1	-0.9	2.4	1.3	0.6
Arm fat mass (right)	1.5	6.0	15.4	-3.9	-3.8	-1.3	-0.8	-1.3	-1.7	3.9	2.4	-2.7	0.3	1.0
Trunk predicted mass	1.5	8.4	18.6	-3.9	-4.0	-1.8	-1.7	-1.3	-3.2	4.3	3.2	-3.2	-0.3	1.9
Standing height	0.7	6.9	15.9	-3.8	-3.4	-0.5	-1.5	0.5	-1.5	4.0	4.0	-1.9	1.0	3.0
Length of working week for main job	0.2	0.2	0.8	0.2	0.0	-0.4	-0.7	-0.5	-0.9	0.1	0.3	-0.2	-0.2	0.9
Exposure to tobacco smoke at home	0.3	0.3	0.8	-0.5	-0.8	-0.2	-0.3	-0.5	-0.3	0.9	0.9	-0.8	0.2	0.3
Breastfed as a baby	0.5	0.6	1.7	0.7	0.8	0.1	0.6	0.7	1.3	-0.7	-0.5	0.9	0.9	0.8
Tense / ‘highly strung’	0.3	0.4	1.6	-0.3	0.4	1.1	0.0	-0.2	0.1	-0.3	0.4	-0.1	1.1	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.3	3.2	-1.3	-1.6	-1.1	-0.6	-0.1	0.1	1.8	1.4	-1.2	0.0	1.6
Hair/balding pattern: Pattern 4	1.5	3.5	7.5	0.4	2.5	1.0	1.5	2.2	2.2	-2.4	-2.5	2.7	0.7	-0.2
Birth weight of first child	1.8	3.4	10.0	-0.7	-1.4	-2.0	-3.2	-2.2	-1.7	1.0	1.8	-2.3	-1.7	0.5
Peak expiratory flow (PEF)	0.3	0.7	2.3	1.3	0.5	0.0	1.0	1.5	1.1	-0.0	-0.0	1.1	0.4	-0.3
Pulse wave reflection index	0.8	0.9	2.2	-1.1	-1.4	-1.4	-0.4	-0.2	-0.8	1.5	0.1	-1.0	-0.7	-0.8
Ever highly irritable/argumentative for 2 days	1.8	2.2	4.3	-1.9	-2.1	-1.0	-1.1	-1.2	-1.6	1.9	0.9	-1.7	-1.6	-0.4
Loud music exposure frequency	0.9	1.0	2.4	-0.4	-1.3	-0.4	-1.2	-1.0	-0.7	1.2	-0.1	-1.6	-1.2	-0.8
Qualifications: O levels/GCSEs or equivalent	0.9	1.5	5.1	0.2	0.5	0.3	-1.7	-2.3	-1.5	-0.8	-1.4	-1.2	-1.1	0.5
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.1	0.2	-0.3	-0.9	-1.1	-0.5	-0.7	0.3	-0.6	-0.8	-0.4	0.6
Blood clot in the leg (DVT)	0.8	1.1	3.4	-1.8	-1.3	-0.2	-0.9	-0.3	-1.5	1.3	0.4	-0.8	-0.8	0.6
Medication: Paracetamol	0.9	1.5	3.9	0.9	1.0	0.8	1.8	1.2	1.1	-1.0	-2.0	1.2	0.2	-1.3
Headache pain in last month	0.3	0.5	1.4	0.7	0.3	0.6	0.4	0.4	-0.7	-0.1	1.0	0.2	1.1	1.2
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.2	1.5	1.0	1.3	0.5	-0.3	-0.9	-1.1	0.5	0.1	-0.3	0.2
Glaucoma (self-reported)	0.7	0.8	2.3	-0.6	-0.6	0.2	1.2	0.2	-0.6	0.9	1.2	-0.4	1.5	1.2
Gout (self-reported)	0.9	1.3	3.8	-1.9	-1.5	-0.9	0.8	0.3	-0.2	1.9	0.9	-0.6	1.2	0.6
Hypothyroidism/myxoedema (self-reported)	3.5	6.8	16.8	-2.4	-1.8	-4.1	-4.1	-3.1	-1.3	1.2	-0.7	-3.1	-3.2	0.2
Medication: Amlodipine	1.0	1.4	6.2	0.4	0.9	1.0	0.7	1.0	0.5	-1.2	-2.5	1.1	-0.5	-1.6
Medication: Ventolin 100micrograms inhaler	3.1	4.0	8.1	-1.6	-2.0	-0.8	-2.9	-2.6	-2.7	1.6	1.4	-2.5	-1.9	0.7
Birth weight	0.7	1.5	3.6	-0.5	-0.7	-1.4	-1.9	-1.4	-0.8	0.6	1.4	-1.4	-0.4	1.8
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.4	-0.8	-0.5	-0.8	-1.2	-0.7	0.7	0.3	0.5	-0.4	-0.5	-0.1
High blood pressure (siblings)	0.3	0.4	1.1	-0.7	-0.5	1.0	-0.6	1.1	0.3	0.6	0.5	0.2	0.8	-0.2
Forced vital capacity (FVC), Best measure	0.1	0.3	0.9	-0.2	-0.4	0.6	-0.3	0.7	1.0	0.5	0.8	0.2	0.1	0.3
Body fat percentage	1.0	4.1	11.7	-3.4	-3.1	-1.3	-0.5	-1.2	-0.8	3.1	2.1	-2.2	0.5	0.7
Leg fat percentage (right)	0.7	2.5	9.3	-3.0	-2.5	-1.3	0.3	-0.8	-0.6	2.4	0.8	-1.6	0.3	-0.2
Arm fat-free mass (right)	2.1	10.9	22.3	-4.4	-4.6	-2.5	-1.9	-2.0	-3.5	4.7	3.5	-3.9	-0.4	1.8
Exposure to tobacco smoke outside home	0.1	0.2	0.4	0.5	0.2	0.5	0.6	0.6	-0.3	-0.0	-0.4	0.3	0.5	-0.0
Comparative body size at age 10	1.4	3.9	7.3	-2.4	-2.6	-2.1	-0.2	-2.4	-2.4	2.1	0.6	-2.7	-1.2	-0.7
Number of full brothers	0.2	0.3	0.9	-0.7	-0.6	-0.1	-0.4	0.2	-0.5	1.0	0.2	0.0	0.3	0.9
Worry too long after embarrassment	0.8	1.4	4.3	2.0	2.0	0.2	-0.5	-0.3	-0.0	-2.1	-0.4	0.7	0.0	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.4	-0.6	-0.4	-0.3	-1.2	-0.6	-0.7	0.3	0.4	-0.9	-1.0	0.7
Wheeze or whistling in the chest in last year	1.2	2.2	5.9	-1.8	-2.2	-0.5	-1.0	-0.6	-1.0	2.4	1.7	-1.8	0.3	1.1
Number of children fathered	1.3	1.5	3.8	0.9	2.0	1.1	-0.1	0.4	1.4	-1.9	-1.4	1.3	0.2	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	3.2	-0.4	0.5	0.9	-0.1	1.4	1.8	-0.2	0.1	1.1	1.1	0.8
Age at first live birth	0.7	1.2	4.6	0.4	0.4	-0.4	-2.1	-0.9	-0.4	-0.2	2.0	-0.4	0.3	1.9
Pulse wave peak to peak time	1.0	1.2	3.6	1.9	1.0	1.2	-0.8	-1.4	-1.4	-1.4	0.4	-0.2	-0.6	0.2
Health satisfaction	0.4	0.5	2.8	0.2	-0.0	-0.2	-0.5	-0.8	-0.0	-0.2	-1.7	-0.4	-0.9	-1.1
Shortness of breath walking on level ground	2.0	2.4	5.0	-1.6	-1.6	-0.9	-1.6	-2.0	-2.2	1.5	1.0	-2.1	-1.1	0.2
Qualifications: College or University degree	0.1	0.5	1.3	0.1	-0.1	-0.2	-1.0	-1.1	-1.1	-0.0	0.5	-0.8	0.2	0.9
Eye problems/disorders: None of the above	0.7	0.8	1.6	0.8	0.9	1.2	-0.1	0.3	0.5	-1.0	-1.1	0.9	-1.2	-1.3
Mouth/teeth dental problems: Loose teeth	1.6	1.9	4.5	-1.0	-2.1	-1.3	0.6	-0.7	-0.8	2.1	1.9	-2.0	-0.2	-0.6
Emphysema/chronic bronchitis	1.1	1.2	3.5	-1.2	-1.4	0.6	-0.7	0.1	-1.0	1.6	1.9	-1.1	0.8	0.7
Medication for pain relief, constipation, heartburn	0.4	0.7	3.5	-0.3	-0.2	-0.4	-1.9	-0.6	-0.3	0.2	1.0	-0.7	-0.8	1.0
Neck or shoulder pain in last month	0.6	0.8	1.9	-0.8	-1.1	-0.6	-0.3	-0.3	-1.1	1.4	0.4	-1.1	0.4	1.4
Medication: Blood pressure	0.4	0.8	2.6	-0.6	-0.2	0.1	0.4	1.0	1.6	0.3	-1.2	0.6	0.8	-1.2
Angina (self-reported)	0.6	0.8	2.7	0.8	0.4	1.5	1.6	0.2	0.1	-0.4	-0.2	0.7	1.0	-1.0
Migraine (self-reported)	0.1	0.1	0.4	0.6	0.2	0.1	0.5	-0.2	0.3	-0.2	0.2	0.3	-0.1	0.6
Medication: Ibuprofen	0.6	0.7	3.5	-0.2	0.0	-0.1	1.9	0.8	0.9	0.1	-0.9	0.3	0.5	-1.1
Medication: Allopurinol	0.8	1.0	2.7	-1.5	-1.1	-0.7	0.5	0.4	-0.4	1.7	1.2	-0.5	1.2	0.9
Medication: Omeprazole	0.7	0.8	2.1	0.2	-1.2	-0.2	0.4	-0.5	-1.4	1.4	1.2	-0.8	0.9	0.2
Medication: Seretide 50 evohaler	0.3	0.4	1.1	0.3	0.7	-0.6	0.3	1.0	0.4	-0.3	-1.1	0.7	0.4	-0.0
Mean time to correctly identify matches	0.7	1.3	3.9	-0.9	-0.9	1.4	-1.6	0.2	0.1	1.1	1.2	-0.6	0.8	2.0
Heart disease (mother)	0.5	0.6	1.9	-1.4	-0.7	0.5	-1.0	1.0	-0.1	0.9	-0.3	0.2	-0.4	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	1.3	0.4	0.4	1.1	-0.2	0.4	0.1	-0.5	-0.6	0.8	0.0	0.0
Whole body fat mass	1.6	6.9	18.1	-4.2	-3.9	-1.7	-1.0	-1.5	-1.6	4.0	2.9	-2.8	0.4	1.2
Leg fat mass (right)	1.5	5.8	16.6	-4.1	-3.7	-1.8	-0.3	-1.2	-1.5	3.8	2.2	-2.5	0.4	1.0
Arm predicted mass (right)	2.2	11.4	23.5	-4.7	-4.7	-2.5	-2.0	-2.0	-3.3	4.8	3.6	-3.9	-0.3	1.9
Pulse rate, automated reading	0.5	1.7	7.0	0.1	0.4	-0.1	2.6	0.4	1.4	-0.4	-2.6	0.7	0.8	-1.3
Alcohol intake frequency.	0.7	1.5	5.4	-2.3	-0.9	0.6	-0.4	0.6	0.2	0.7	-1.6	-0.1	-2.0	-1.4
Comparative height size at age 10	1.6	8.9	21.8	-3.6	-3.3	-1.5	-2.6	-0.7	-1.9	3.9	4.0	-2.5	1.2	4.7
Number of full sisters	2.0	2.4	5.2	-2.0	-1.4	-0.2	0.4	1.3	-0.1	2.0	2.3	-0.2	2.0	2.2
Suffer from ‘nerves’	0.3	0.5	1.9	-0.3	0.2	0.8	-1.4	-0.3	-0.2	-0.2	1.0	0.1	0.1	1.1
Overall health rating	0.1	0.2	0.6	-0.6	-0.2	-0.2	-0.6	0.1	0.6	0.5	-0.6	-0.3	0.7	0.3
Chest pain or discomfort	1.5	2.2	5.8	-0.5	-1.6	-0.6	-2.0	-2.3	-1.3	1.3	1.4	-2.4	-0.3	0.7
Had major operations	0.6	0.7	2.0	-1.4	-1.1	-0.2	-0.2	0.2	-1.0	1.2	0.6	-0.7	0.7	0.8
Age at last live birth	0.5	0.7	2.9	-0.3	-0.5	0.2	-1.5	-0.3	-0.9	0.5	1.7	-0.8	-0.1	0.5
Family relationship satisfaction	0.8	1.0	3.5	-0.3	-0.9	-1.4	-0.5	-1.9	-1.0	0.4	-0.1	-1.2	-1.4	0.1
Leg pain on walking	0.5	0.6	1.8	0.8	0.1	0.1	-0.9	-1.0	-1.4	-0.2	-0.2	-0.8	-1.3	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.1	0.6	0.4	0.0	1.1	1.0	0.4	-0.4	-0.5	0.8	0.4	-0.4
Commuting to job workplace: Car/motor vehicle	1.3	1.4	4.7	0.8	-0.4	-2.2	-1.1	-1.7	-1.5	-0.0	0.1	-1.2	-1.5	-0.6
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.5	-0.1	-0.1	-0.5	-0.9	-0.3	-0.2	-0.1	-0.9	-0.3	-1.2	-0.7
Medication: Aspirin	1.3	1.7	3.8	-1.9	-1.6	-1.1	1.7	0.1	-0.1	1.8	1.3	-0.7	1.6	0.2
Supplements: Vitamin C	0.9	1.1	3.3	-0.1	-0.8	-0.7	-1.4	-1.8	-1.3	0.6	0.3	-1.7	0.3	0.5
Knee pain experienced in last month	0.7	1.2	3.1	-1.4	-0.9	-1.8	-0.6	-1.4	-0.3	0.6	-0.8	-1.2	-1.2	-0.8
Hypertension (Self-reported)	1.0	2.7	8.6	-1.1	-0.0	0.2	2.6	2.2	2.0	0.0	-2.9	1.3	0.5	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	3.8	0.4	0.3	0.7	1.1	1.2	-0.2	0.0	0.4	0.9	1.9	1.3
Illnesses of father: Heart disease	2.5	3.4	6.7	-2.1	-2.6	-1.9	-1.0	-2.1	-1.7	2.1	0.4	-2.3	-2.0	-0.9
Illnesses of siblings: Diabetes	0.8	0.9	3.6	0.8	-0.4	0.2	-0.8	-1.0	-1.3	-0.2	-0.4	-0.8	-1.3	-1.9
Smoking status: Previous	1.7	2.6	9.6	-3.1	-2.2	-0.5	0.1	0.7	1.2	2.5	1.3	-1.0	1.1	1.0
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.4	8.4	-2.0	-2.5	-0.8	-1.3	-0.3	-1.8	2.9	2.2	-2.1	0.2	1.9
Whole body fat-free mass	1.7	10.0	21.3	-4.3	-4.4	-2.2	-2.0	-1.7	-3.3	4.6	3.4	-3.6	-0.5	1.9
Leg fat-free mass (right)	1.6	8.8	19.5	-4.1	-4.1	-1.9	-1.7	-1.6	-2.8	4.4	3.4	-3.3	-0.2	1.9
Arm fat percentage (left)	0.7	2.7	7.6	-2.8	-2.4	-0.6	-0.1	-0.6	-0.7	2.6	2.0	-1.5	1.0	1.0
Average weekly red wine intake	0.5	0.8	3.0	1.1	0.2	-0.6	-0.6	-1.3	-1.7	-0.6	0.8	-0.9	-0.3	0.1
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.1	0.3	0.7	0.1	1.1	0.9	1.0	-0.7	-0.6	1.0	0.7	-0.2
Mood swings	0.2	0.3	0.7	0.5	0.8	0.6	-0.3	0.5	0.7	-0.8	-0.2	0.3	-0.4	0.1
Loneliness, isolation	0.4	0.5	2.0	0.0	1.1	1.4	-0.0	0.1	-0.5	-1.2	-0.5	0.7	0.2	0.1
Long-standing illness, disability or infirmity	2.5	3.8	7.5	-2.1	-2.5	-1.5	-2.2	-1.6	-2.4	2.2	0.0	-2.7	-1.7	0.1
Ever had bowel cancer screening	1.4	1.6	3.5	-1.4	-1.5	-0.7	0.5	-0.3	-1.7	1.7	1.9	-1.4	0.5	1.0
Diabetes diagnosed by doctor	0.3	0.5	1.7	-0.8	-0.7	0.3	1.3	0.9	0.6	0.6	-0.5	-0.0	0.4	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	3.7	-1.9	-1.5	-0.2	0.7	0.1	-0.7	1.5	0.6	-0.8	-0.6	-0.2
Friendships satisfaction	1.0	1.2	4.9	-0.3	0.5	-0.4	-0.7	-1.2	-1.2	-1.1	-1.6	-0.1	-2.2	-0.9
Qualifications: nursing, teaching	0.7	1.2	3.5	-0.2	-0.7	-0.4	-1.5	-1.0	-1.0	0.3	-0.7	-1.1	-1.6	-1.9
Commuting to job workplace: Walk	1.4	1.6	6.9	-2.6	-1.5	0.8	0.6	1.0	0.8	1.9	-0.8	-0.5	0.8	-0.6
Eye problems/disorders: Cataract	0.1	0.2	0.3	-0.5	0.3	-0.6	-0.2	-0.5	-0.4	-0.4	-0.5	0.0	0.2	-0.2
Mouth/teeth dental problems: Mouth ulcers	1.3	2.0	6.3	0.6	-0.7	-2.5	-1.0	-2.5	-1.2	0.2	-1.4	-1.4	-1.5	-0.5
Medication for cholesterol	1.0	1.5	5.4	1.0	0.0	-1.4	-1.9	-2.3	-1.1	-0.5	0.6	-0.9	-1.2	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.8	1.0	-0.4	-0.1	-1.4	-1.1	-1.1	0.4	0.8	-0.8	-0.5	0.7
Back pain experienced in last month	0.2	0.3	1.5	-1.2	-0.6	-0.1	0.1	0.1	0.5	0.7	-0.1	-0.1	-0.2	-0.6
Mineral and other dietary supplements	0.5	0.7	2.7	-1.0	-1.4	-0.1	1.0	0.8	0.5	1.6	0.0	-0.3	-0.2	-0.0
Breast cancer (self-reported)	0.5	0.6	1.6	0.9	1.0	0.8	0.8	-0.1	1.3	-1.0	-0.0	0.9	0.4	0.3
Asthma (self-reported)	3.3	6.6	14.1	-1.6	-2.6	-2.4	-3.8	-3.4	-2.6	2.2	1.1	-3.7	-2.4	0.5
Osteoporosis (self-reported)	1.3	1.7	8.3	1.2	0.0	-0.9	-2.9	-1.0	-0.9	-0.0	1.2	-1.2	-0.6	1.6
Osteoarthritis (self-reported)	0.4	0.5	1.5	0.8	0.8	0.5	0.8	-0.5	-1.2	-0.9	0.2	0.3	0.2	-0.7
Medication: Aspirin	1.0	1.3	3.0	-1.7	-1.6	-1.5	1.2	-0.5	-0.5	1.6	0.8	-1.0	0.7	-0.5
Medication: Gliclazide	0.8	0.9	3.0	-0.6	-0.6	0.5	1.2	0.4	-0.9	0.8	1.7	-0.4	1.4	0.8
Illnesses of father: None of the above (group 1)	2.3	2.8	5.8	1.9	2.4	1.8	0.4	1.5	2.0	-2.1	-0.5	2.0	1.3	1.4
Smoking status: Current	0.5	0.7	1.6	-0.7	-0.9	-0.8	-1.3	-1.3	-0.6	0.8	0.6	-1.1	-0.7	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.1	4.4	12.0	1.3	1.5	2.4	3.5	2.6	2.5	-1.2	0.1	2.9	1.9	-1.0
Whole body water mass	1.8	10.2	21.4	-4.3	-4.4	-2.2	-2.0	-1.7	-3.3	4.6	3.5	-3.6	-0.5	2.0
Leg predicted mass (right)	1.6	8.8	19.4	-4.1	-4.1	-1.8	-1.7	-1.6	-2.8	4.4	3.4	-3.3	-0.2	1.9
Arm fat mass (left)	1.5	6.0	14.9	-3.8	-3.7	-1.3	-0.9	-1.3	-1.7	3.9	2.6	-2.7	0.5	1.2
Number of self-reported non-cancer illnesses	3.5	6.1	17.9	-4.2	-3.4	-2.9	-1.8	-1.7	-2.0	3.0	0.3	-2.9	-1.4	0.5
Average weekly champagne plus white wine intake	0.3	0.4	1.3	1.1	0.4	-0.6	0.3	-0.4	-0.7	-0.4	-0.1	-0.1	-0.7	-1.0
Miserableness	0.3	0.6	2.4	0.4	-0.1	-1.0	-0.9	-0.8	-0.8	0.0	0.5	-0.7	-1.5	0.4
Guilty feelings	0.2	0.4	1.4	0.5	0.2	0.0	-1.0	-0.6	-0.8	-0.3	-0.2	-0.4	-1.2	-0.3
Wears glasses or contact lenses	1.5	1.8	3.5	-0.7	-1.2	-1.4	-1.6	-1.7	-1.9	0.7	1.1	-1.8	-1.2	-0.4
Ever taken oral contraceptive pill	0.6	0.6	1.5	-0.1	-0.8	-0.9	-0.8	-1.1	-0.7	0.9	-0.1	-1.2	-0.6	0.5
Hearing aid user	3.5	3.9	10.6	-1.4	-2.3	-1.5	-3.3	-0.6	-2.4	2.7	1.7	-2.1	-0.8	1.4
Mother’s age at death	0.8	1.1	3.9	2.0	1.3	0.9	-0.8	0.0	1.2	-1.6	-0.0	0.7	-0.1	-0.2
Financial situation satisfaction	1.0	1.3	6.5	0.1	-0.6	-0.4	-0.7	-1.6	-2.5	0.4	0.6	-1.3	-1.2	-0.3
Tinnitus: Yes, now most or all of the time	1.7	2.0	3.7	-1.9	-1.7	-1.1	-1.1	-0.9	-1.9	1.9	1.3	-1.6	-0.6	0.0
Commuting to job workplace: Public transport	0.3	0.3	1.1	-0.2	-0.4	0.2	-0.6	-1.1	-0.8	0.2	0.1	-0.8	-0.0	-0.6
Eye problems/disorders: Glaucoma	0.5	0.6	1.8	-0.6	-0.6	-0.2	0.6	-0.2	-0.7	0.9	0.6	-0.7	1.3	1.2
Medication: Blood pressure	0.9	1.7	5.5	-0.5	-0.1	0.8	2.2	1.8	1.3	0.1	-2.3	0.9	0.1	-1.2
Pain type(s) experienced in last month: Hip pain	0.8	1.0	5.9	-0.5	-0.7	-0.2	-2.4	-1.2	-0.1	0.5	-0.5	-1.1	-1.2	-0.1
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.6	0.3	0.5	-0.2	-0.8	-0.6	-0.5	-0.7	0.0	-0.2	-0.6	-0.8
High cholesterol (Self-reported)	0.3	0.6	2.1	-1.5	-0.8	-0.9	0.3	0.6	1.0	0.9	-0.2	-0.1	0.7	0.2
Medication: Bendroflumethiazide	1.4	2.1	5.1	1.2	1.3	0.9	1.5	2.3	1.4	-0.9	-0.8	1.7	2.0	1.2
Medication: Paracetamol	0.2	0.4	1.9	0.8	0.0	-0.3	0.7	-0.3	-0.4	-0.3	-0.8	0.0	-0.2	-1.4
Medication: Lisinopril	1.4	1.8	8.7	-0.4	-0.9	-0.5	0.2	-0.2	-0.6	0.4	-1.8	-0.3	-2.4	-3.0
Medication: Atorvastatin	1.0	1.2	4.5	-0.2	-0.4	0.8	2.1	1.3	0.9	0.7	1.1	0.9	1.9	0.2
Illnesses of father: High blood pressure	0.7	0.8	2.9	0.0	-0.7	-0.9	1.7	-0.5	-1.4	0.6	-0.0	-0.5	1.1	-0.9
Alcohol drinker status: Never	0.3	0.3	1.9	-0.4	-0.2	-0.1	-0.7	-0.3	0.1	-0.0	-0.9	-0.1	-1.4	-0.2
Ever smoked	0.9	1.6	5.4	-2.3	-1.4	-0.2	-0.6	0.2	0.9	1.7	1.0	-0.8	1.1	1.6
Basal metabolic rate	2.0	11.0	24.3	-4.7	-4.7	-2.2	-1.9	-1.8	-3.3	4.9	3.5	-3.8	-0.4	1.8
Leg fat percentage (left)	0.8	3.1	8.7	-3.0	-2.7	-1.6	0.1	-1.2	-1.1	2.6	1.1	-2.0	0.1	-0.5
Arm fat-free mass (left)	2.2	11.2	23.0	-4.5	-4.8	-2.5	-1.8	-2.2	-3.7	4.8	3.2	-4.0	-0.8	1.4
Number of operations (self-reported)	0.4	0.5	1.4	-0.3	-1.2	-0.1	0.1	0.2	-0.9	1.1	0.8	-0.8	0.7	0.8
Average weekly beer plus cider intake	0.2	0.3	1.4	-0.9	-0.3	0.1	-0.7	0.3	-0.6	0.4	1.2	-0.4	-0.0	0.0
Irritability	0.4	0.7	1.9	0.1	0.4	1.2	0.9	1.4	1.4	-0.1	-0.3	0.8	0.5	-0.8
Risk taking	0.9	1.3	4.0	-1.2	-1.1	-0.8	0.5	-1.2	-1.7	1.0	2.0	-1.2	0.5	-0.3
Ever had prostate specific antigen (PSA) test	1.2	1.3	4.2	-0.3	-1.1	-1.2	-1.3	-1.4	-2.1	0.9	0.3	-1.2	-0.7	1.0
Fractured/broken bones in last 5 years	0.2	0.2	1.7	0.2	0.2	-0.2	0.1	-0.2	-0.6	-0.3	-1.3	0.0	-0.2	-0.3
Age started oral contraceptive pill	0.2	0.2	1.2	-0.3	0.4	-0.5	0.3	-0.0	0.4	-0.4	-1.1	0.2	0.3	-0.4
Diastolic blood pressure, automated reading	0.8	2.5	10.8	-0.5	0.2	1.1	3.3	1.5	1.2	0.2	-1.8	1.3	1.8	-2.0
Ever depressed for a whole week	3.4	4.1	7.8	-1.9	-2.8	-1.9	-1.3	-1.6	-2.0	2.5	2.3	-2.7	-1.9	0.2
Unable to work because of sickness or disability	0.2	0.2	0.6	-0.4	-0.5	0.0	0.6	-0.3	-0.1	0.8	0.1	-0.8	0.4	0.6
Commuting to job workplace: Cycle	0.1	0.1	0.5	0.0	-0.0	0.4	-0.7	0.2	0.1	0.2	-0.5	0.2	0.2	0.4
Myopia	0.2	0.2	1.8	-1.3	-0.3	0.2	0.2	-0.2	-0.2	0.1	-0.0	-0.2	-0.2	-0.7
Vascular/heart problems diagnosed by doctor	0.8	2.1	7.4	1.3	0.3	-0.1	-2.7	-1.7	-1.5	-0.3	2.3	-1.1	-0.7	1.4
Cholesterol lowering medication	0.7	1.1	4.2	-1.4	-0.1	-0.0	1.5	2.0	1.1	0.4	-0.3	1.0	0.8	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.7	0.5	-0.5	0.0	0.4	-0.4	-1.3	0.6	0.5	-0.4	0.8	0.1
Pain experienced in last month	0.3	0.4	1.3	-0.3	-0.9	-0.3	-0.7	-0.3	-1.1	0.7	0.4	-0.4	-0.8	-0.4
Supplements: Calcium	0.6	0.7	3.4	-0.2	0.4	-0.2	-1.8	0.1	0.7	0.0	0.7	-0.2	0.5	1.7
Basal cell carcinoma (self-reported)	0.6	0.7	1.5	-0.1	0.4	1.2	1.2	0.5	1.1	-0.2	-0.7	0.9	1.2	0.6
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.6	-0.2	-0.5	-0.4	0.1	-0.8	-0.3	0.4	1.3	-0.3	0.2	1.1
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	3.9	-2.0	-1.5	-0.5	-1.2	-0.6	-1.6	1.5	0.5	-1.0	-1.1	0.5
Heart disease (siblings)	0.3	0.4	2.0	0.5	0.1	-0.6	0.2	-0.8	1.4	-0.3	0.8	-0.2	-0.3	-0.6
Alcohol drinker status: Previous	1.1	1.2	5.7	-2.4	-1.3	-0.1	-0.5	0.9	-0.1	1.3	-0.9	-0.4	-0.9	-1.2
Pack years of smoking	0.5	0.7	2.3	0.0	0.5	1.5	1.3	0.8	0.1	-0.4	0.3	0.9	1.0	-0.6
Impedance of whole body	0.6	3.1	7.0	1.6	2.1	1.7	1.2	1.9	2.6	-2.0	-1.3	2.4	1.0	-0.1
Leg fat mass (left)	1.7	6.5	16.8	-4.1	-3.9	-2.0	-0.4	-1.4	-1.8	4.0	2.4	-2.8	0.3	0.7
Arm predicted mass (left)	2.3	11.6	25.6	-4.8	-4.9	-2.3	-1.8	-1.9	-3.5	5.1	3.3	-3.9	-0.4	1.8