Best TWAS P=4.05e-10 · Best GWAS P=1.62e-08 conditioned to 0.286
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | PIGX | 0.11 | 0.05 | lasso | 2 | 0.04 | 3.4e-04 | -5.3 | 5.3 | 1.1e-07 | -0.91 | 0.02 | 0.98 | FALSE |
2 | GTEx | Adipose Visceral Omentum | CEP19 | 0.27 | 0.15 | lasso | 4 | 0.15 | 5.3e-08 | -5.6 | 5.6 | 2.0e-08 | -1.00 | 0.01 | 0.99 | FALSE |
3 | GTEx | Adrenal Gland | CEP19 | 0.24 | 0.17 | lasso | 3 | 0.15 | 4.8e-06 | -5.6 | 5.6 | 2.4e-08 | -0.99 | 0.01 | 0.98 | FALSE |
4 | GTEx | Artery Aorta | PIGX | 0.19 | 0.12 | lasso | 3 | 0.12 | 3.6e-07 | -5.5 | 5.4 | 6.1e-08 | -0.90 | 0.01 | 0.99 | FALSE |
5 | GTEx | Artery Aorta | CEP19 | 0.17 | 0.09 | lasso | 2 | 0.05 | 8.5e-04 | -5.2 | 5.4 | 8.6e-08 | -0.95 | 0.02 | 0.98 | FALSE |
6 | GTEx | Artery Coronary | CEP19 | 0.33 | 0.15 | lasso | 3 | 0.14 | 2.0e-05 | -5.2 | 5.2 | 1.8e-07 | -0.90 | 0.01 | 0.97 | FALSE |
7 | GTEx | Artery Tibial | CEP19 | 0.11 | 0.07 | lasso | 3 | 0.07 | 5.3e-06 | -5.6 | 5.5 | 3.0e-08 | -0.99 | 0.01 | 0.99 | FALSE |
8 | GTEx | Brain Caudate basal ganglia | CEP19 | 0.31 | 0.18 | lasso | 5 | 0.18 | 8.0e-06 | -5.1 | 5.4 | 6.0e-08 | -0.98 | 0.02 | 0.97 | FALSE |
9 | GTEx | Cells Transformed fibroblasts | CEP19 | 0.38 | 0.23 | lasso | 6 | 0.24 | 2.2e-18 | -5.6 | 5.2 | 2.2e-07 | -0.96 | 0.01 | 0.99 | FALSE |
10 | GTEx | Esophagus Muscularis | PIGX | 0.12 | 0.01 | lasso | 5 | 0.02 | 3.7e-02 | -5.5 | 5.3 | 1.3e-07 | -0.87 | 0.01 | 0.96 | FALSE |
11 | GTEx | Esophagus Muscularis | CEP19 | 0.16 | 0.11 | lasso | 4 | 0.07 | 3.4e-05 | -5.2 | 5.4 | 8.0e-08 | -0.96 | 0.02 | 0.98 | FALSE |
12 | GTEx | Heart Atrial Appendage | CEP19 | 0.19 | 0.08 | lasso | 6 | 0.07 | 5.9e-04 | -5.5 | 5.6 | 2.2e-08 | -0.97 | 0.01 | 0.98 | FALSE |
13 | GTEx | Lung | PIGX | 0.21 | 0.08 | enet | 7 | 0.08 | 1.8e-06 | -5.1 | 5.4 | 5.1e-08 | -0.96 | 0.02 | 0.98 | FALSE |
14 | GTEx | Nerve Tibial | CEP19 | 0.45 | 0.26 | lasso | 8 | 0.25 | 7.4e-18 | -5.2 | 5.3 | 1.5e-07 | -0.96 | 0.03 | 0.97 | FALSE |
15 | GTEx | Skin Not Sun Exposed Suprapubic | PIGX | 0.17 | 0.11 | lasso | 3 | 0.13 | 1.7e-07 | -5.5 | 5.7 | 1.5e-08 | -0.96 | 0.01 | 0.99 | FALSE |
16 | GTEx | Skin Sun Exposed Lower leg | PIGX | 0.13 | 0.10 | lasso | 4 | 0.09 | 4.7e-08 | -5.5 | 5.5 | 2.9e-08 | -0.92 | 0.01 | 0.99 | FALSE |
17 | GTEx | Skin Sun Exposed Lower leg | NRROS | 0.07 | 0.02 | enet | 14 | 0.03 | 9.6e-04 | -4.6 | -5.6 | 2.8e-08 | 0.17 | 0.10 | 0.42 | TRUE |
18 | GTEx | Stomach | PIGX | 0.22 | 0.18 | lasso | 2 | 0.16 | 3.7e-08 | -5.2 | 5.2 | 1.9e-07 | -0.94 | 0.03 | 0.97 | FALSE |
19 | GTEx | Testis | CEP19 | 0.58 | 0.50 | lasso | 2 | 0.50 | 5.6e-25 | -5.5 | 5.5 | 4.1e-08 | -1.00 | 0.01 | 0.99 | FALSE |
20 | GTEx | Thyroid | PIGX | 0.12 | 0.05 | lasso | 3 | 0.04 | 2.3e-04 | -5.2 | 5.5 | 4.8e-08 | -0.93 | 0.02 | 0.97 | FALSE |
21 | GTEx | Whole Blood | CEP19 | 0.10 | 0.09 | lasso | 3 | 0.09 | 8.0e-09 | -5.5 | 5.4 | 6.8e-08 | -0.98 | 0.02 | 0.98 | FALSE |
22 | METSIM | Adipose | CEP19 | 0.15 | 0.04 | enet | 14 | 0.09 | 5.4e-14 | -5.2 | 5.9 | 4.4e-09 | -0.82 | 0.03 | 0.97 | FALSE |
23 | NTR | Blood | PIGX | 0.04 | 0.03 | bslmm | 421 | 0.03 | 6.4e-10 | -5.5 | 6.3 | 4.0e-10 | -0.81 | 0.01 | 0.99 | TRUE |
24 | YFS | Blood | PIGX | 0.07 | 0.04 | bslmm | 441 | 0.04 | 4.0e-14 | -5.3 | 5.1 | 2.9e-07 | -0.85 | 0.02 | 0.98 | FALSE |
25 | The Cancer Genome Atlas | Colon Adenocarcinoma | PIGX | 0.06 | 0.01 | blup | 66 | 0.01 | 6.6e-02 | -5.3 | 5.6 | 2.7e-08 | -0.85 | 0.01 | 0.88 | FALSE |
26 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C3orf34 | 0.08 | 0.14 | lasso | 5 | 0.15 | 2.3e-16 | -5.2 | 5.3 | 1.3e-07 | -0.94 | 0.03 | 0.97 | FALSE |
27 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PIGX | 0.08 | 0.08 | lasso | 4 | 0.08 | 4.5e-09 | -5.5 | 5.3 | 1.1e-07 | -0.88 | 0.01 | 0.99 | FALSE |
28 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C3orf34 | 0.05 | 0.07 | lasso | 1 | 0.06 | 1.1e-07 | -5.5 | 5.5 | 4.0e-08 | -1.00 | 0.01 | 0.99 | FALSE |
29 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | C3orf34 | 0.06 | 0.05 | lasso | 2 | 0.02 | 2.8e-02 | -5.6 | 5.5 | 4.0e-08 | -1.00 | 0.01 | 0.94 | FALSE |
30 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C3orf34 | 0.07 | 0.09 | lasso | 2 | 0.09 | 1.2e-10 | -5.5 | 5.7 | 1.2e-08 | -0.96 | 0.01 | 0.99 | FALSE |
31 | The Cancer Genome Atlas | Lung Adenocarcinoma | C3orf34 | 0.05 | 0.05 | enet | 10 | 0.04 | 1.5e-05 | -5.2 | 5.7 | 1.5e-08 | -0.97 | 0.01 | 0.98 | FALSE |
32 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C3orf34 | 0.04 | 0.04 | lasso | 2 | 0.04 | 2.0e-05 | -5.5 | 5.8 | 7.7e-09 | -0.94 | 0.01 | 0.99 | FALSE |
33 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PIGX | 0.03 | 0.03 | enet | 8 | 0.04 | 2.6e-05 | -5.5 | 5.7 | 9.0e-09 | -0.83 | 0.01 | 0.97 | FALSE |
34 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C3orf34 | 0.20 | 0.21 | lasso | 5 | 0.23 | 1.5e-08 | -5.2 | 5.1 | 2.9e-07 | -0.92 | 0.02 | 0.98 | FALSE |