Hub : Genes

NRROS

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Caudate basal ganglia	0.548	0.1290	0.00270	0.000	NA	0.110	NA	0.035	3.3e-01	NA	4.7e-04	NA	3.4e-02
2	GTEx	Nerve Tibial	0.192	0.0641	0.00160	0.078	NA	0.060	NA	0.067	3.3e-06	NA	4.7e-05	NA	1.8e-05
3	GTEx	Skin Sun Exposed Lower leg	0.073	0.0330	0.00350	0.016	NA	0.033	NA	0.009	1.5e-02	NA	9.6e-04	NA	5.6e-02
4	METSIM	Adipose	0.101	0.0345	0.00012	0.009	0.02	0.037	0.02	0.022	1.2e-02	0.00039	2.4e-06	0.00048	2.2e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.7	1.1	3.6	-0.2	-1.9	-0.8	0.2
Bipolar Disorder or Schizophrenia	1.7	4.0	8.9	-1.4	-1.7	-3.0	-1.6
Depressed Affect (Nagel 2018)	1.2	2.4	5.7	-2.0	0.3	-2.4	0.2
Depression (Nagel 2018)	1.4	2.1	5.4	-1.3	-0.4	-1.1	2.3
Intelligence (Savage-Jansen 2018)	0.6	1.7	3.3	1.1	1.8	-0.3	-1.5
Neuroticism (Nagel 2018)	1.2	2.8	6.8	-2.6	-0.4	-2.0	-0.1
Schizophrenia (2018)	2.4	4.9	9.3	-1.7	-0.5	-3.0	-2.7
Schizophrenia vs Biploar Disorder	0.1	0.1	0.5	0.7	0.1	0.1	0.0
Worry (Nagel 2018)	0.7	1.6	3.2	-1.8	-1.0	-0.9	-1.1
Alzheimer’s Disease (in mother)	1.0	1.2	3.0	1.7	-0.1	0.4	-1.3
Alzheimer’s Disease (in father)	0.9	1.0	2.0	-0.5	1.4	-0.7	-1.1
Alzheimer’s Disease (including proxy)	0.9	1.3	4.0	1.1	0.3	-0.1	-2.0
Crohns Disease (2017)	1.9	4.3	8.3	-2.2	-2.9	-1.8	-0.7
Irritable Bowel Disease (IBD)	0.7	1.7	5.6	-2.4	-1.0	0.5	0.3
Ulcerative Colitis (UC)	0.9	1.6	4.3	-1.0	0.6	2.1	0.8
Major Depression (MDD)	0.1	0.2	0.3	0.3	0.3	0.6	0.4
Reaction Time	0.5	1.0	3.1	-1.8	0.1	-0.6	0.7
Verbal and Numeric Reasoning (VNR)	0.5	1.3	2.9	0.3	1.1	0.9	-1.7
Breast Cancer	0.2	0.4	0.8	0.9	0.3	-0.7	-0.6
Ovarian Cancer	0.2	0.3	1.0	1.0	-0.4	-0.2	0.3
Prostate Cancer	0.1	0.2	0.4	0.6	-0.4	-0.1	0.2
Age at First Birth	1.0	1.5	4.1	0.8	0.7	2.0	0.9
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.8	1.0	2.6	-0.9	0.4	-0.8	-1.6
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.6	0.9	1.5	-1.2	-1.2	0.2	-0.8
Mean Putamen Volume	1.2	1.4	4.2	-0.5	-2.0	-0.9	-0.6
Fasting Glucose	0.7	0.8	1.4	-0.3	0.8	1.2	-1.2
HbA1C	0.9	1.0	2.8	-0.9	0.2	1.7	0.6
HDL Cholesterol	1.3	2.2	4.0	-2.0	0.6	-1.8	-1.2
LDL Cholesterol	0.3	0.5	1.3	0.8	0.2	1.1	-0.2
Lupus	0.4	0.6	0.9	-0.9	0.9	-0.2	-0.9
Neuroticism (2016)	2.3	3.3	5.6	-2.4	-0.4	-1.8	-2.0
Primary Biliary Cirrhosis	1.0	1.4	4.3	1.1	0.0	2.1	0.2
Rheumatoid Arthritis	5.7	7.8	19.6	-2.0	-2.7	-4.4	-0.4
Schizophrenia (2014)	1.2	2.6	5.5	-0.9	-1.0	-2.4	-1.7
Triglycerides	0.4	0.7	1.1	0.8	-0.5	-1.0	0.8
Type 2 Diabetes (T2D) (2012)	0.4	0.5	0.7	0.8	0.5	-0.8	-0.6
Ulcerative Colitis	0.6	0.9	1.9	-1.4	0.1	1.2	0.5
Blood Eosinophil Count	3.0	22.7	63.7	0.2	-4.1	-8.0	-3.2
Blood Platelet Count	0.2	2.1	3.8	1.0	-1.8	-0.6	-1.9
Blood Red Count	0.2	1.7	3.5	-1.9	-0.8	-1.1	-1.2
Blood White Count	0.7	5.4	9.2	-2.5	-1.5	-3.0	-2.0
Heel T-Score	0.3	2.5	4.3	1.3	-0.1	-2.1	-2.0
BMI	1.0	5.7	9.1	0.4	3.0	-2.6	2.6
Height	0.0	0.8	1.7	-0.2	0.5	-1.1	1.3
Waist Hip Ratio (WHR)	0.6	2.9	6.1	1.4	-1.9	-2.5	0.1
Systolic Blood Pressure	1.7	8.4	27.9	-2.3	-0.5	-0.5	-5.3
Smoking Status	1.6	3.8	7.8	-1.8	0.8	-1.8	2.8
Allergy or Eczema	6.1	16.1	30.8	0.9	-4.0	-5.6	-4.1
Cardiovascular Disease	0.7	2.1	4.9	-1.3	-2.2	-1.3	-0.6
Hypothyroidism (self reported)	1.6	3.8	8.0	2.8	-2.6	-0.2	0.3
Respiratory disease	7.4	16.4	29.7	-1.0	-4.7	-5.4	-3.5
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.1	0.2	-1.0	-0.3	0.8
Lung FEV1/FVC ratio	0.3	1.3	3.5	0.8	0.7	-0.9	1.9
Lung FVC	0.6	3.1	7.0	-0.8	1.2	2.6	-1.9
Neuroticism	1.8	4.5	11.7	-3.4	-0.0	-2.5	-0.3
Chronotype (morning person)	0.8	2.0	3.9	-0.1	2.0	1.9	-0.7
Hair Pigment	0.0	0.3	0.4	-0.5	-0.5	-0.4	0.6
Tanning	0.2	2.5	4.4	1.9	-1.2	0.7	2.1
Hand grip strength (left)	1.2	3.3	12.0	3.5	0.0	0.9	-0.4
Number of treatments/medications taken	2.1	3.7	5.7	-2.0	-2.2	-2.4	-0.0
Average weekly spirits intake	2.2	2.7	5.7	0.2	-1.5	-1.6	2.4
Sensitivity / hurt feelings	0.7	1.3	2.3	-1.1	-0.5	-1.5	-1.1
Frequency of depressed mood in last 2 weeks	1.3	1.8	4.2	-1.6	-0.1	-0.6	2.0
Hearing difficulty/problems: Yes	1.5	2.3	7.8	-0.4	-1.1	-2.8	-0.0
Relative age of first facial hair	0.6	1.1	3.3	0.8	0.2	1.8	0.7
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	4.8	-0.9	-2.2	-0.1	0.0
Ever used hormone-replacement therapy (HRT)	0.7	0.8	1.3	-1.1	0.7	-0.6	1.1
Ever had hysterectomy (womb removed)	0.2	0.2	0.6	-0.1	-0.8	0.1	0.4
Systolic blood pressure, automated reading	0.6	1.9	3.6	-1.9	-0.5	-0.7	-1.8
Eye problems/disorders: Diabetes related eye disease	2.0	2.2	4.0	2.0	-1.1	-1.7	1.0
Angina	1.6	2.1	4.3	-2.1	-0.1	0.1	2.0
Medication for hormone replacement therapy	1.7	2.0	5.2	-1.1	0.5	-1.1	-2.3
Vitamin and mineral supplements	0.1	0.2	0.3	0.6	0.3	-0.3	-0.6
Supplements: Zinc	0.4	0.5	0.9	-0.8	-0.6	1.0	-0.1
Medication: Co-codamol	2.4	2.8	8.2	-0.3	-0.6	-2.9	-1.6
Medication: Metformin	0.7	1.0	3.3	-0.1	-0.7	-0.2	1.8
Diabetes (father)	2.2	2.8	4.6	1.4	-1.5	-2.1	-1.4
Diabetes (mother)	0.3	0.3	0.8	-0.1	-0.3	-0.7	0.9
Severe depression (siblings)	0.1	0.1	0.4	0.2	-0.3	0.6	0.1
Pack years adult smoking proportion	1.0	1.5	3.0	-1.7	0.2	-0.8	1.5
Impedance of leg (right)	1.6	7.9	14.1	-1.1	-3.6	-1.7	-3.8
Leg fat-free mass (left)	0.9	4.7	12.8	0.9	2.2	-0.7	3.6
Trunk fat percentage	0.9	3.6	8.7	-0.9	1.1	-2.9	1.9
Hand grip strength (right)	1.0	2.8	9.5	3.1	0.7	0.9	-0.8
Townsend deprivation index at recruitment	0.9	1.3	3.4	-0.0	0.9	1.8	1.0
Current tobacco smoking	0.6	1.0	1.6	-0.7	0.7	-1.1	1.3
Average weekly fortified wine intake	1.4	1.7	4.4	0.9	-1.2	0.3	2.1
Maternal smoking around birth	1.3	1.8	6.1	-2.5	-0.6	-0.9	0.1
Fed-up feelings	0.7	1.3	3.0	-1.7	0.5	-0.8	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.2	-0.7	0.1	-1.1	0.8
Relative age voice broke	0.2	0.3	1.0	-0.2	0.1	1.0	-0.4
Taking other prescription medications	2.0	3.1	6.4	0.1	-2.4	-2.5	-0.3
Age when periods started (menarche)	0.2	0.5	1.0	0.9	0.3	-0.1	-1.0
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.9	-0.3	-0.3	0.2	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.7	-0.4	-0.3	-1.6	0.5
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	5.3	-0.7	0.7	2.3	0.2
Qualifications: CSEs or equivalent	0.9	1.2	2.8	-1.7	0.6	0.3	-1.2
Serious illness, injury or assault to yourself	0.5	0.6	1.9	-0.3	-1.4	0.5	-0.5
High blood pressure	0.7	2.1	3.7	-1.7	-1.3	-1.9	0.4
Hayfever, allergic rhinitis or eczema	4.7	10.3	18.1	0.6	-3.4	-4.3	-3.3
Multivitamins +/- minerals	0.1	0.1	0.2	-0.4	-0.2	-0.4	0.4
Stomach or abdominal pain in last month	0.4	0.5	1.4	0.1	0.4	1.2	0.5
Supplements: Glucosamine	1.9	2.5	6.9	0.0	-1.0	-2.6	1.4
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	1.7	0.4	1.3	-1.2	-1.3
Medication: Atenolol	0.2	0.2	0.5	-0.7	0.4	0.3	-0.1
Medication: Levothyroxine sodium	1.2	2.0	6.2	1.1	-2.5	0.6	0.0
Sitting height	0.2	1.3	2.4	1.6	-0.9	1.2	-0.7
Chronic bronchitis/emphysema (father)	0.7	0.8	1.4	-1.0	-1.2	-0.8	-0.4
High blood pressure (mother)	0.4	0.6	1.0	0.2	0.7	-0.9	-1.0
Body mass index (BMI)	1.2	5.0	7.2	0.0	2.6	-2.7	2.5
Impedance of leg (left)	1.2	6.1	13.5	-1.0	-3.0	-0.8	-3.7
Leg predicted mass (left)	0.9	4.7	12.8	0.9	2.1	-0.7	3.6
Trunk fat mass	1.0	4.2	6.6	-0.5	1.9	-2.6	2.5
Waist circumference	1.5	5.4	14.9	-0.2	1.1	-3.9	2.4
Number of incorrect matches in round	0.7	1.2	2.0	-1.3	-0.2	-1.4	-1.1
Past tobacco smoking	1.9	3.6	8.1	2.5	-0.2	0.4	-2.8
Alcohol usually taken with meals	0.2	0.4	0.7	-0.1	0.3	-0.8	0.8
Nervous feelings	1.2	2.3	4.7	-1.6	-0.9	-1.0	-2.2
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	4.6	-2.1	-0.1	-1.4	-0.1
Hearing difficulty/problems with background noise	1.1	1.7	3.6	-1.9	0.0	-1.7	0.3
Hair/balding pattern: Pattern 2	0.6	0.7	1.3	-1.1	-1.1	0.1	-0.6
Had menopause	1.7	2.1	4.5	-2.1	-0.1	-0.9	1.8
Had other major operations	1.0	1.2	3.4	0.4	-0.0	1.2	1.8
Forced vital capacity (FVC)	0.8	3.0	10.4	0.1	0.9	3.2	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.6	-0.2	-0.6	-1.3	0.4
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	0.7	-0.3	-0.7	0.7	-0.8
Qualifications: None of the above	0.9	1.9	6.5	-2.5	-0.1	-0.6	0.9
Financial difficulties in last 2 years	0.9	1.2	1.9	-1.0	0.4	-1.4	-1.3
Mouth/teeth dental problems	0.7	1.1	2.7	-0.6	1.6	0.7	-0.9
Heart attack	1.2	1.5	3.4	-1.5	1.8	0.5	-0.5
Allergy	5.0	11.4	23.8	-0.4	3.6	4.9	3.0
Pain all over the body in last month	0.6	0.7	1.5	-0.1	-0.6	0.9	1.2
Diabetes (self-reported)	0.5	0.8	1.4	0.8	-0.8	-0.7	1.2
Hayfever/allergic rhinitis (self-reported)	5.3	7.0	12.1	1.1	-2.6	-3.5	-2.8
Medication: Ramipril	3.3	4.2	7.4	-0.2	-2.0	-2.7	2.3
Medication: Simvastatin	2.1	3.0	7.2	-2.7	-1.8	-1.3	-0.2
Fluid intelligence score	0.3	0.7	1.1	0.8	0.4	-0.8	-1.0
Illnesses of siblings	1.1	1.5	5.0	0.9	-2.2	0.1	0.5
Neuroticism score	1.6	3.3	9.2	-3.0	-0.1	-1.8	-0.9
Weight	1.0	4.8	8.2	0.1	2.5	-2.3	2.9
Impedance of arm (right)	0.6	2.8	5.7	-1.2	-2.4	1.1	-1.7
Arm fat percentage (right)	0.9	3.6	5.9	-0.6	2.2	-2.4	1.9
Trunk fat-free mass	0.5	3.0	6.0	1.2	2.1	-0.5	2.4
Hip circumference	1.1	4.8	8.2	-1.1	2.4	-2.9	2.1
Time employed in main current job	0.2	0.3	0.6	-0.3	-0.7	-0.6	-0.3
Alcohol intake versus 10 years previously	0.2	0.3	1.2	0.3	-0.2	0.1	1.1
Father’s age at death	1.2	1.6	2.6	1.1	1.1	-1.3	-1.6
Worrier / anxious feelings	0.7	1.4	5.5	-2.4	0.2	-0.3	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.8	-1.7	0.8	-0.6	-0.9
Falls in the last year	2.2	2.9	4.7	-1.9	1.8	-2.2	0.4
Hair/balding pattern: Pattern 3	1.3	2.0	3.7	0.7	-1.1	-1.9	-1.5
Number of live births	0.7	1.0	2.5	-0.5	1.0	-0.6	-1.6
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	9.1	0.6	1.3	3.0	0.1
Pulse rate	0.0	0.1	0.1	-0.4	-0.2	0.0	-0.3
Happiness	0.1	0.1	0.3	0.4	0.0	0.6	-0.1
Noisy workplace	0.7	0.8	1.9	0.2	0.1	1.1	1.4
Qualifications: A levels/AS levels or equivalent	1.3	2.8	9.1	1.2	0.2	3.0	-0.8
Serious illness, injury or assault of a close relative in last 2 years	3.5	4.1	11.9	-0.0	3.5	1.2	-1.7
Mouth/teeth dental problems: Dentures	0.5	0.8	2.4	0.7	-0.5	-0.1	1.6
Asthma	6.7	13.2	20.7	-0.4	-4.4	-4.5	-3.6
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.7	3.9	0.5	-1.6	-2.0	0.3
Medication: Cholesterol lowering	2.3	3.6	8.3	-2.9	-0.6	-2.4	0.4
Depression (self-reported)	1.3	1.5	2.4	1.0	1.4	0.8	1.6
Medication: Lansoprazole	2.3	2.6	3.8	-1.7	-0.9	-1.9	-1.7
Prospective memory result	1.5	1.8	4.0	-0.7	0.4	1.6	2.0
Lung cancer (father)	0.3	0.4	1.2	-0.5	-0.2	-0.2	1.1
Illnesses of mother	1.3	1.7	4.6	-1.1	0.6	2.1	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	4.5	1.6	0.7	2.1	0.2
Pulse wave Arterial Stiffness index	0.7	0.8	1.3	-1.1	-0.9	0.2	1.0
Impedance of arm (left)	0.6	2.8	7.9	-1.4	-2.8	0.3	-1.2
Arm fat mass (right)	1.1	4.5	7.0	0.1	2.6	-2.4	2.3
Trunk predicted mass	0.5	2.9	5.6	1.2	2.1	-0.5	2.4
Standing height	0.0	0.3	1.1	0.1	0.1	0.4	1.1
Length of working week for main job	0.8	0.9	1.8	-1.4	0.1	0.9	-1.0
Exposure to tobacco smoke at home	0.5	0.6	1.8	0.1	-1.4	-0.2	0.6
Breastfed as a baby	0.7	0.9	3.0	0.7	0.2	-1.7	0.0
Tense / ‘highly strung’	1.1	1.9	3.8	-1.8	-0.5	-0.7	-1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.9	-0.9	-0.6	0.5	0.4
Hair/balding pattern: Pattern 4	0.8	1.8	3.3	-1.8	1.7	1.1	0.3
Birth weight of first child	0.4	0.8	1.8	-0.3	0.8	-1.4	0.6
Peak expiratory flow (PEF)	0.2	0.6	1.3	0.2	0.9	0.4	1.2
Pulse wave reflection index	0.9	1.1	1.9	0.5	-0.7	1.4	1.2
Ever highly irritable/argumentative for 2 days	1.1	1.3	4.0	-0.4	-0.5	-0.9	2.0
Loud music exposure frequency	2.2	2.4	7.0	-2.6	-0.5	1.6	-0.0
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	3.9	1.9	1.3	0.7	-2.0
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	3.1	0.8	-1.8	-0.3	0.9
Blood clot in the leg (DVT)	1.5	1.9	7.4	0.1	0.3	0.4	2.7
Medication: Paracetamol	2.0	3.2	10.0	-3.2	-1.2	0.1	1.3
Headache pain in last month	1.5	2.5	4.9	-2.2	1.3	0.8	1.7
Medication for cholesterol, blood pressure or diabetes	2.1	3.4	8.1	2.8	0.1	2.3	-0.3
Glaucoma (self-reported)	0.3	0.3	1.0	-0.3	-0.4	-0.3	1.0
Gout (self-reported)	0.6	0.8	2.1	-0.8	0.3	-0.5	1.5
Hypothyroidism/myxoedema (self-reported)	1.1	2.1	5.8	1.6	-2.4	-0.4	-0.3
Medication: Amlodipine	1.0	1.3	4.2	-2.0	1.0	0.5	-0.0
Medication: Ventolin 100micrograms inhaler	2.8	3.6	7.3	-1.3	-1.9	-2.7	-1.4
Birth weight	0.4	0.9	1.5	0.7	1.1	-0.7	1.2
Chronic bronchitis/emphysema (mother)	0.8	0.9	3.0	-0.5	0.1	-1.7	-0.5
High blood pressure (siblings)	0.5	0.8	2.0	-0.7	1.4	0.2	-0.8
Forced vital capacity (FVC), Best measure	0.6	2.1	6.2	1.3	0.5	2.5	-0.6
Body fat percentage	1.1	4.3	10.5	-1.1	1.6	-3.2	1.7
Leg fat percentage (right)	1.6	5.9	19.7	-1.3	1.4	-4.4	0.6
Arm fat-free mass (right)	0.6	3.2	6.2	1.1	1.9	-1.4	2.5
Exposure to tobacco smoke outside home	0.3	0.5	0.8	-0.3	-0.8	0.6	0.9
Comparative body size at age 10	0.7	1.9	4.6	-0.3	2.1	-1.0	1.3
Number of full brothers	0.8	1.1	2.3	0.7	-1.5	-1.0	0.6
Worry too long after embarrassment	1.3	2.2	7.0	-2.6	-0.1	-1.2	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.8	0.0	0.5	0.5	-1.3
Wheeze or whistling in the chest in last year	3.1	5.4	20.2	-0.3	-1.0	-4.5	-0.8
Number of children fathered	0.3	0.4	0.9	-0.4	0.9	-0.3	0.6
Reason for reducing amount of alcohol drunk: Health precaution	3.0	3.5	6.1	-1.6	-2.5	-1.9	-1.4
Age at first live birth	0.5	0.8	3.3	0.1	0.2	1.8	0.2
Pulse wave peak to peak time	0.6	0.7	1.2	1.0	0.7	-0.3	-1.1
Health satisfaction	0.1	0.1	0.1	0.2	-0.3	-0.1	0.3
Shortness of breath walking on level ground	2.1	2.5	3.4	1.8	1.8	-0.4	1.8
Qualifications: College or University degree	0.3	1.0	2.9	0.9	0.6	1.7	-0.4
Eye problems/disorders: None of the above	0.5	0.6	1.5	0.4	-0.2	1.2	-0.7
Mouth/teeth dental problems: Loose teeth	0.4	0.4	0.9	-0.4	0.7	-0.5	0.9
Emphysema/chronic bronchitis	2.9	3.3	5.7	-2.1	1.7	0.5	2.4
Medication for pain relief, constipation, heartburn	1.7	2.8	5.1	1.5	1.4	1.4	-2.3
Neck or shoulder pain in last month	1.6	2.3	5.1	-2.3	0.4	-1.2	1.6
Medication: Blood pressure	1.5	2.7	9.2	-3.0	0.1	-1.1	0.6
Angina (self-reported)	1.6	2.1	4.6	-1.9	0.0	0.3	2.1
Migraine (self-reported)	1.3	1.6	3.9	-1.6	-0.1	2.0	0.2
Medication: Ibuprofen	1.5	1.7	3.6	0.8	-1.9	-1.5	0.6
Medication: Allopurinol	0.4	0.6	1.7	-0.7	0.3	-0.1	1.3
Medication: Omeprazole	1.0	1.2	4.7	-0.2	-0.2	-2.2	0.2
Medication: Seretide 50 evohaler	0.7	0.8	2.1	0.8	-0.5	-1.5	0.5
Mean time to correctly identify matches	1.2	2.3	5.7	-2.4	1.4	-0.9	0.9
Heart disease (mother)	1.8	2.1	4.4	-0.2	-2.1	-1.2	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	3.2	0.2	-0.1	-0.6	-1.8
Whole body fat mass	1.1	4.6	7.5	-0.7	2.1	-2.7	2.4
Leg fat mass (right)	1.3	5.1	11.6	-0.9	2.0	-3.4	2.0
Arm predicted mass (right)	0.6	3.2	6.6	0.9	1.7	-1.5	2.6
Pulse rate, automated reading	0.5	1.6	4.4	-0.1	-0.7	-2.1	-1.2
Alcohol intake frequency.	0.6	1.5	4.1	1.0	0.3	0.8	2.0
Comparative height size at age 10	0.1	0.8	2.7	-1.6	-0.5	-0.0	0.6
Number of full sisters	0.5	0.5	1.6	0.6	0.3	-1.3	-0.4
Suffer from ‘nerves’	0.5	0.8	1.3	-1.0	-1.1	-0.8	-0.7
Overall health rating	0.5	1.1	2.4	-0.9	0.9	-1.5	0.6
Chest pain or discomfort	0.5	0.7	2.0	-0.0	1.4	-0.4	0.9
Had major operations	0.4	0.5	1.3	0.4	0.1	-1.1	-0.7
Age at last live birth	0.4	0.6	0.8	0.7	-0.6	0.8	0.9
Family relationship satisfaction	0.4	0.5	1.1	0.5	1.0	-0.4	0.7
Leg pain on walking	1.5	1.9	4.0	-0.7	1.2	-2.0	1.3
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.6	-0.5	-0.9	-1.3	0.2
Commuting to job workplace: Car/motor vehicle	0.9	1.1	2.8	-0.5	-1.1	-1.7	-0.0
Illness, injury, bereavement, stress in last 2 years	1.6	1.9	4.4	1.0	-1.1	1.0	2.1
Medication: Aspirin	2.4	3.1	10.2	-1.3	-0.2	0.7	3.2
Supplements: Vitamin C	0.9	1.1	1.9	-0.9	0.6	1.4	1.1
Knee pain experienced in last month	1.3	2.0	5.8	-0.9	-1.2	-2.4	0.1
Hypertension (Self-reported)	1.1	3.0	6.2	-2.0	-1.4	-2.5	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.4	-1.6	0.7	0.9	-0.2
Illnesses of father: Heart disease	0.7	1.0	1.9	-0.4	1.3	-1.4	0.4
Illnesses of siblings: Diabetes	1.3	1.6	2.8	-1.6	1.0	0.1	1.7
Smoking status: Previous	1.6	2.4	6.6	-2.6	0.2	-0.8	1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	1.0	0.3	-0.6	0.9	-1.0
Whole body fat-free mass	0.7	3.8	9.1	1.1	2.1	-0.5	3.0
Leg fat-free mass (right)	0.9	4.8	12.5	1.1	2.4	0.0	3.5
Arm fat percentage (left)	1.1	4.3	7.0	-0.5	2.2	-2.6	2.3
Average weekly red wine intake	0.3	0.4	1.0	-0.6	-1.0	-0.6	0.0
Handedness (chirality/laterality): Left-handed	0.9	1.0	1.7	-1.3	-1.3	-0.9	0.1
Mood swings	1.6	3.0	6.1	-2.5	1.1	-2.0	0.6
Loneliness, isolation	0.0	0.1	0.2	-0.4	-0.2	0.1	0.0
Long-standing illness, disability or infirmity	0.6	0.9	3.1	0.1	0.1	-1.7	0.7
Ever had bowel cancer screening	0.7	0.8	2.4	-0.6	0.1	-1.6	0.5
Diabetes diagnosed by doctor	0.6	0.9	2.2	0.4	-0.9	-0.7	1.5
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.5	-0.5	0.7	-0.3	-0.6
Friendships satisfaction	0.7	0.9	1.4	-0.7	0.7	1.2	-1.1
Qualifications: nursing, teaching	0.9	1.4	2.8	1.2	1.2	1.7	0.3
Commuting to job workplace: Walk	1.5	1.6	5.7	0.2	-0.0	2.4	0.8
Eye problems/disorders: Cataract	0.9	1.0	3.3	0.5	0.4	-1.8	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.7	0.4	-1.3	-0.7	-0.8
Medication for cholesterol	0.5	0.7	1.8	0.2	0.3	0.9	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.7	-0.4	0.8	-0.8	-0.5
Back pain experienced in last month	0.9	1.3	4.0	0.3	-1.0	-2.0	0.4
Mineral and other dietary supplements	1.0	1.4	2.8	1.3	1.7	0.3	-1.0
Breast cancer (self-reported)	0.3	0.4	0.9	-0.3	-0.9	0.0	0.7
Asthma (self-reported)	7.7	15.3	25.3	-0.4	-4.6	-5.0	-3.8
Osteoporosis (self-reported)	0.4	0.5	1.0	1.0	-0.1	0.9	0.3
Osteoarthritis (self-reported)	2.1	2.7	5.3	-1.3	-1.6	-2.3	-1.1
Medication: Aspirin	2.6	3.4	11.4	-1.1	-0.1	1.0	3.4
Medication: Gliclazide	0.2	0.3	0.5	0.7	0.3	0.3	0.7
Illnesses of father: None of the above (group 1)	2.0	2.5	5.0	1.5	0.1	2.2	1.7
Smoking status: Current	0.6	0.9	1.8	-0.3	0.6	-1.2	1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	2.7	1.2	0.6	1.6	1.0
Whole body water mass	0.6	3.6	8.5	0.9	2.1	-0.6	2.9
Leg predicted mass (right)	0.9	4.9	12.7	1.1	2.4	-0.0	3.6
Arm fat mass (left)	1.2	4.8	6.9	-0.2	2.3	-2.6	2.6
Number of self-reported non-cancer illnesses	3.3	5.7	12.3	-1.6	-3.5	-2.6	-1.2
Average weekly champagne plus white wine intake	0.7	0.9	3.3	0.6	-0.1	1.8	0.1
Miserableness	1.8	3.1	4.9	-1.4	2.0	-2.2	1.3
Guilty feelings	1.3	1.9	7.2	-2.7	0.2	-0.7	-0.3
Wears glasses or contact lenses	0.7	0.8	1.9	-1.4	0.5	-0.5	1.0
Ever taken oral contraceptive pill	0.6	0.7	2.2	0.2	-0.1	1.5	0.6
Hearing aid user	0.3	0.4	0.9	0.5	-0.3	-1.0	0.5
Mother’s age at death	0.9	1.1	2.4	0.6	-1.2	-1.6	-0.4
Financial situation satisfaction	0.5	0.6	0.9	-1.0	-1.0	-0.6	-0.3
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.1	0.9	-1.5	0.8	1.3
Commuting to job workplace: Public transport	0.3	0.4	1.3	1.1	-0.4	0.0	-0.4
Eye problems/disorders: Glaucoma	0.6	0.7	2.0	-0.7	-0.7	0.3	1.4
Medication: Blood pressure	0.6	1.1	2.9	0.6	-1.0	-1.7	0.7
Pain type(s) experienced in last month: Hip pain	1.5	1.9	3.8	-0.6	-1.1	-2.0	1.4
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.9	-0.6	-0.8	-0.9	0.3
High cholesterol (Self-reported)	0.3	0.6	1.3	-1.1	-0.6	-0.6	-0.5
Medication: Bendroflumethiazide	0.4	0.7	2.2	-0.6	1.5	-0.2	0.1
Medication: Paracetamol	2.0	3.1	6.2	-2.5	-2.1	0.2	1.3
Medication: Lisinopril	1.9	2.5	8.0	-2.8	0.5	-0.6	-1.1
Medication: Atorvastatin	0.2	0.3	0.8	0.0	0.9	0.6	-0.1
Illnesses of father: High blood pressure	0.6	0.7	1.1	-0.7	-1.1	0.2	-1.1
Alcohol drinker status: Never	0.5	0.6	1.1	1.0	-0.8	0.9	-0.2
Ever smoked	1.8	3.1	6.4	-2.4	0.5	-0.0	2.5
Basal metabolic rate	0.7	3.7	8.0	1.0	2.2	-1.0	2.8
Leg fat percentage (left)	1.3	4.8	13.8	-1.2	1.9	-3.7	0.8
Arm fat-free mass (left)	0.5	2.8	4.6	1.1	1.9	-1.3	2.1
Number of operations (self-reported)	0.4	0.7	1.4	-0.9	1.2	-0.6	-0.1
Average weekly beer plus cider intake	0.0	0.0	0.1	0.3	0.1	-0.1	-0.2
Irritability	0.6	1.0	3.7	-1.9	0.2	0.2	-0.4
Risk taking	0.4	0.5	1.7	-0.2	0.5	-1.3	0.4
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.1	0.3	-0.1	0.2	-0.1
Fractured/broken bones in last 5 years	0.8	1.0	1.7	-1.3	-1.2	-0.8	-0.0
Age started oral contraceptive pill	0.5	0.6	1.7	1.3	-0.0	0.0	0.8
Diastolic blood pressure, automated reading	0.9	2.6	10.4	-0.4	-0.2	-0.0	-3.2
Ever depressed for a whole week	1.0	1.2	3.9	-0.1	0.6	2.0	-0.8
Unable to work because of sickness or disability	0.3	0.3	0.6	0.2	0.7	-0.5	0.8
Commuting to job workplace: Cycle	1.0	1.3	2.3	1.5	-0.6	-0.4	-1.5
Myopia	0.3	0.4	1.3	1.2	-0.0	0.2	0.6
Vascular/heart problems diagnosed by doctor	0.7	1.8	3.7	1.9	0.8	1.4	-0.9
Cholesterol lowering medication	0.6	0.9	2.6	-0.2	-1.6	-0.9	-0.4
Medication: Omeprazole (e.g. Zanprol)	1.3	1.5	3.5	-1.1	-1.2	-1.9	0.1
Pain experienced in last month	1.7	2.9	4.7	2.2	-0.2	1.8	-1.9
Supplements: Calcium	2.8	3.1	6.1	-0.7	-2.5	0.2	2.4
Basal cell carcinoma (self-reported)	1.6	2.0	4.7	0.7	-2.2	-1.6	0.4
Heart attack/myocardial infarction (self-reported)	1.1	1.4	3.2	-1.8	1.3	0.4	-0.7
Deep venous thrombosis (DVT) (self-reported)	1.7	2.2	8.3	0.2	0.2	0.6	2.9
Heart disease (siblings)	0.2	0.3	0.6	0.8	-0.6	-0.3	0.4
Alcohol drinker status: Previous	1.1	1.3	4.2	0.1	2.1	0.6	0.7
Pack years of smoking	1.3	1.9	4.2	-2.0	0.2	-0.8	1.6
Impedance of whole body	1.1	5.4	12.4	-1.1	-3.5	-0.5	-2.8
Leg fat mass (left)	1.2	4.7	8.9	-0.8	2.3	-3.0	2.0
Arm predicted mass (left)	0.6	3.2	6.0	1.0	2.5	-1.4	2.0