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chr4:38,079,294-39,824,758

Best TWAS P=1.55e-96 · Best GWAS P=6.03e-105 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	TLR1	0.08	0.07	lasso	2	0.07	1.3e-08	-18.97	-20.1	6.4e-90	0.88	0.24	0.76	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TLR6	0.13	0.05	bslmm	513	0.08	2.1e-10	1.64	-6.3	2.9e-10	0.11	1.00	0.00	TRUE
3	GTEx	Adipose Subcutaneous	FAM114A1	0.21	0.17	lasso	5	0.17	9.5e-14	-2.07	-8.8	1.1e-18	0.37	1.00	0.00	FALSE
4	GTEx	Artery Coronary	RP11-360F5.3	0.21	0.11	enet	32	0.00	4.2e-01	0.99	-8.4	3.7e-17	0.40	0.18	0.33	FALSE
5	GTEx	Breast Mammary Tissue	FAM114A1	0.11	0.04	lasso	3	0.05	1.0e-03	-19.02	-13.9	6.8e-44	0.63	0.23	0.36	FALSE
6	GTEx	Breast Mammary Tissue (Female)	FAM114A1	0.07	-0.01	lasso	4	0.01	1.7e-01	-5.72	-9.4	4.9e-21	0.50	0.04	0.15	FALSE
7	GTEx	Cells Transformed fibroblasts	TLR6	0.28	0.19	lasso	5	0.17	1.7e-12	-17.59	17.8	3.9e-71	-0.76	1.00	0.00	FALSE
8	GTEx	Esophagus Mucosa	TLR1	0.20	0.02	lasso	6	0.04	9.8e-04	-17.59	19.5	5.6e-85	-0.88	0.02	0.98	TRUE
9	GTEx	Esophagus Mucosa	FAM114A1	0.14	0.03	lasso	11	0.03	6.6e-03	8.41	-12.8	1.8e-37	0.53	0.66	0.18	TRUE
10	GTEx	Esophagus Muscularis	TLR1	0.21	0.02	enet	46	0.06	2.3e-04	-17.04	12.9	2.7e-38	-0.54	0.05	0.87	FALSE
11	GTEx	Skin Not Sun Exposed Suprapubic	TLR6	0.29	0.03	lasso	11	0.08	4.8e-05	6.41	16.1	3.4e-58	-0.65	0.64	0.24	FALSE
12	GTEx	Skin Sun Exposed Lower leg	TLR6	0.17	0.12	lasso	7	0.10	1.6e-08	6.41	10.5	5.1e-26	-0.41	1.00	0.00	FALSE
13	GTEx	Testis	FAM114A1	0.37	0.20	lasso	7	0.20	2.2e-09	-19.92	-18.6	1.3e-77	0.79	0.70	0.28	TRUE
14	NTR	Blood	KLHL5	0.06	0.01	enet	26	0.04	3.1e-12	7.11	-5.3	1.2e-07	0.29	0.90	0.02	FALSE
15	NTR	Blood	TLR1	0.03	0.00	bslmm	520	0.01	3.0e-03	-20.33	12.3	8.0e-35	-0.56	0.06	0.50	FALSE
16	ROSMAP	Brain Pre-frontal Cortex	TLR10	0.08	0.01	blup	517	0.03	3.4e-05	-8.49	10.9	1.4e-27	-0.58	0.62	0.23	TRUE
17	ROSMAP	Brain Pre-frontal Cortex	TLR1	0.08	0.02	blup	514	0.03	2.3e-05	-17.83	-17.5	1.1e-68	0.68	0.04	0.95	FALSE
18	YFS	Blood	TLR1	0.08	0.05	bslmm	525	0.07	1.2e-20	-21.39	17.1	7.5e-66	-0.80	0.60	0.40	TRUE
19	YFS	Blood	TLR6	0.05	0.04	bslmm	505	0.06	1.3e-18	-18.99	17.6	1.2e-69	-0.79	0.99	0.01	FALSE
20	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TLR6	0.03	0.02	lasso	2	0.01	3.5e-02	-17.59	17.6	1.9e-69	-0.75	0.06	0.09	FALSE
21	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TLR1	0.04	0.03	lasso	4	0.03	8.2e-05	-20.33	20.8	1.5e-96	-0.92	0.01	0.99	TRUE
22	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TLR10	0.09	0.06	lasso	2	0.06	2.3e-04	-14.13	14.2	9.2e-46	-0.57	0.16	0.05	TRUE
23	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	TLR1	0.14	0.07	enet	12	0.10	1.7e-05	-17.83	18.2	8.3e-74	-0.81	0.24	0.70	FALSE
24	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TLR1	0.03	0.03	enet	23	0.03	1.5e-04	-20.33	13.4	1.1e-40	-0.69	0.04	0.88	TRUE
25	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TLR1	0.08	0.02	enet	11	0.04	1.1e-03	-13.65	7.4	1.0e-13	-0.32	0.02	0.05	TRUE
26	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TLR6	0.10	0.13	lasso	1	0.10	4.4e-05	6.41	6.4	1.4e-10	-0.23	0.37	0.03	FALSE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	TLR6	0.07	0.02	blup	65	0.01	4.7e-02	9.65	-9.1	6.5e-20	0.52	0.08	0.07	TRUE
28	The Cancer Genome Atlas	Thyroid Carcinoma	TLR6	0.06	0.04	lasso	3	0.04	1.1e-04	-4.31	-6.0	2.6e-09	0.38	0.09	0.30	FALSE
29	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	TLR1	0.13	0.13	enet	3	0.08	2.6e-03	-12.81	16.3	5.1e-60	-0.79	0.02	0.74	FALSE