Best TWAS P=1.05e-11 · Best GWAS P=3.48e-11 conditioned to 0.0129
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | PSMB7 | 0.08 | 0.04 | lasso | 6 | 0.04 | 3.4e-04 | 6.1 | -5.9 | 3.8e-09 | -0.89 | 0.11 | 0.87 | FALSE |
| 2 | GTEx | Artery Aorta | PSMB7 | 0.15 | 0.03 | enet | 16 | 0.05 | 1.4e-03 | -5.2 | -5.6 | 2.0e-08 | -0.62 | 0.12 | 0.44 | FALSE |
| 3 | GTEx | Artery Tibial | PSMB7 | 0.07 | 0.04 | enet | 7 | 0.03 | 4.1e-03 | 6.1 | -5.4 | 6.3e-08 | -0.85 | 0.04 | 0.93 | FALSE |
| 4 | GTEx | Colon Sigmoid | PSMB7 | 0.15 | 0.10 | lasso | 3 | 0.09 | 3.3e-04 | 6.5 | -6.3 | 2.3e-10 | -0.95 | 0.03 | 0.95 | FALSE |
| 5 | GTEx | Nerve Tibial | NEK6 | 0.11 | 0.02 | enet | 40 | 0.03 | 3.9e-03 | 5.7 | -6.0 | 2.5e-09 | -0.40 | 0.06 | 0.60 | FALSE |
| 6 | GTEx | Thyroid | NEK6 | 0.20 | 0.21 | lasso | 4 | 0.20 | 1.3e-15 | 6.6 | -6.7 | 2.4e-11 | -0.96 | 0.00 | 1.00 | FALSE |
| 7 | GTEx | Thyroid | PSMB7 | 0.06 | 0.04 | lasso | 2 | 0.06 | 4.1e-05 | 4.7 | -5.7 | 9.0e-09 | -0.87 | 0.02 | 0.97 | FALSE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NEK6 | 0.04 | 0.02 | blup | 87 | 0.02 | 2.5e-05 | -4.8 | -5.8 | 7.1e-09 | -0.53 | 0.47 | 0.48 | FALSE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NEK6 | 0.06 | 0.01 | blup | 87 | 0.04 | 1.0e-04 | -4.8 | -6.8 | 1.0e-11 | -0.72 | 0.01 | 0.96 | TRUE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PSMB7 | 0.03 | 0.04 | lasso | 4 | 0.04 | 1.2e-04 | 5.6 | -5.1 | 2.6e-07 | -0.86 | 0.10 | 0.81 | FALSE |