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chr9:122,881,960-124,487,495

Best TWAS P=3.97e-14 · Best GWAS P=3.55e-14 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	TRAF1	0.09	0.11	enet	26	0.12	1.7e-14	7.5	-6.3	2.2e-10	-0.92	0.01	0.99	FALSE
2	GTEx	Adrenal Gland	PSMD5	0.40	0.22	enet	37	0.23	7.2e-09	4.4	6.6	3.9e-11	0.77	0.03	0.97	FALSE
3	GTEx	Artery Aorta	C5	0.06	0.02	lasso	8	0.02	2.9e-02	6.7	5.7	1.2e-08	0.70	0.10	0.49	FALSE
4	GTEx	Artery Coronary	PSMD5-AS1	0.56	0.50	enet	31	0.55	1.3e-21	4.4	5.6	1.9e-08	0.62	0.88	0.12	FALSE
5	GTEx	Artery Tibial	TRAF1	0.04	0.05	lasso	2	0.03	1.2e-03	6.7	6.7	2.9e-11	0.88	0.36	0.38	FALSE
6	GTEx	Brain Caudate basal ganglia	TRAF1	0.17	0.22	lasso	11	0.20	2.1e-06	7.6	-7.6	4.0e-14	-1.00	0.01	0.98	TRUE
7	GTEx	Brain Cerebellar Hemisphere	TRAF1	0.42	0.24	lasso	10	0.16	6.8e-05	7.5	-6.9	5.2e-12	-0.95	0.01	0.98	FALSE
8	GTEx	Brain Cerebellum	TRAF1	0.42	0.24	enet	26	0.34	7.2e-11	7.4	-6.5	1.1e-10	-0.88	0.01	0.99	FALSE
9	GTEx	Brain Nucleus accumbens basal ganglia	TRAF1	0.29	0.25	lasso	12	0.22	1.9e-06	7.5	-7.5	6.3e-14	-0.98	0.01	0.98	FALSE
10	GTEx	Brain Putamen basal ganglia	TRAF1	0.26	0.21	lasso	6	0.19	2.3e-05	7.6	-7.4	1.4e-13	-0.98	0.02	0.97	FALSE
11	GTEx	Esophagus Muscularis	PHF19	0.16	0.06	lasso	8	0.07	3.1e-05	6.8	-5.6	2.7e-08	-0.69	0.43	0.42	FALSE
12	GTEx	Muscle Skeletal	TRAF1	0.10	0.02	lasso	7	0.01	1.9e-02	7.4	-6.4	1.4e-10	-0.92	0.01	0.99	FALSE
13	GTEx	Muscle Skeletal	PSMD5	0.31	0.31	enet	20	0.34	6.0e-34	4.4	5.2	2.4e-07	0.61	1.00	0.00	FALSE
14	GTEx	Nerve Tibial	TRAF1	0.23	0.08	lasso	7	0.19	1.1e-13	-1.1	-5.2	2.2e-07	-0.73	0.02	0.98	FALSE
15	GTEx	Prostate	PSMD5-AS1	0.63	0.33	lasso	9	0.47	2.2e-13	4.5	5.6	2.4e-08	0.69	0.08	0.92	FALSE
16	GTEx	Skin Not Sun Exposed Suprapubic	TRAF1	0.25	0.17	lasso	12	0.16	4.4e-09	6.8	7.0	2.7e-12	0.92	0.04	0.96	FALSE
17	GTEx	Skin Sun Exposed Lower leg	TRAF1	0.11	0.09	lasso	5	0.09	1.4e-07	6.7	6.2	4.9e-10	0.79	0.81	0.19	FALSE
18	GTEx	Small Intestine Terminal Ileum	PSMD5-AS1	0.49	0.48	enet	14	0.41	2.5e-10	4.5	5.6	2.2e-08	0.70	0.40	0.59	FALSE
19	GTEx	Testis	TRAF1	0.25	0.27	lasso	3	0.27	1.8e-12	7.4	-7.5	9.3e-14	-1.00	0.01	0.99	FALSE
20	YFS	Blood	PHF19	0.05	0.03	enet	21	0.04	2.9e-14	6.7	-6.2	6.7e-10	-0.80	0.12	0.88	FALSE
21	The Cancer Genome Atlas	Breast Invasive Carcinoma	TRAF1	0.04	0.04	lasso	3	0.05	7.2e-10	7.5	-7.6	4.2e-14	-0.99	0.01	0.99	FALSE
22	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LOC253039	0.20	0.25	blup	37	0.25	1.8e-28	4.5	5.1	2.9e-07	0.61	1.00	0.00	FALSE
23	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TRAF1	0.05	0.00	blup	56	0.02	1.9e-02	6.5	-7.1	1.0e-12	-0.95	0.02	0.70	FALSE
24	The Cancer Genome Atlas	Prostate Adenocarcinoma	PHF19	0.03	0.03	lasso	2	0.02	3.6e-03	6.5	-6.5	1.0e-10	-0.83	0.04	0.60	FALSE
25	The Cancer Genome Atlas	Prostate Adenocarcinoma	TRAF1	0.07	0.06	blup	53	0.08	1.7e-08	7.5	-6.7	1.5e-11	-0.91	0.02	0.98	FALSE
26	The Cancer Genome Atlas	Testicular Germ Cell Tumors	LOC253039	0.55	0.49	enet	10	0.48	3.0e-19	4.4	5.2	2.4e-07	0.67	1.00	0.00	FALSE
27	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PSMD5	0.23	0.09	blup	41	0.16	3.6e-06	7.6	6.5	9.2e-11	0.84	0.00	0.99	FALSE