Best TWAS P=2.8e-13 · Best GWAS P=7.88e-14 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LAYN | 0.19 | 0.24 | bslmm | 398 | 0.25 | 8.0e-30 | -5.9 | 6.1 | 1.1e-09 | -0.82 | 0.99 | 0.01 | FALSE |
| 2 | GTEx | Brain Putamen basal ganglia | LAYN | 0.24 | 0.12 | lasso | 7 | 0.13 | 6.2e-04 | -5.8 | 6.1 | 8.6e-10 | -0.87 | 0.03 | 0.83 | FALSE |
| 3 | GTEx | Esophagus Mucosa | SIK2 | 0.13 | 0.03 | lasso | 4 | 0.02 | 2.2e-02 | -7.4 | -7.3 | 2.8e-13 | 0.97 | 0.01 | 0.95 | TRUE |
| 4 | GTEx | Testis | PPP2R1B | 0.34 | 0.21 | lasso | 10 | 0.36 | 1.5e-16 | -6.3 | 5.2 | 1.8e-07 | -0.72 | 0.97 | 0.03 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | LAYN | 0.19 | 0.23 | enet | 26 | 0.25 | 2.9e-32 | -5.9 | 6.6 | 5.7e-11 | -0.89 | 0.99 | 0.01 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LAYN | 0.02 | 0.03 | blup | 33 | 0.03 | 3.7e-06 | -5.9 | -6.4 | 1.1e-10 | 0.86 | 0.21 | 0.79 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SIK2 | 0.04 | 0.01 | blup | 35 | 0.01 | 6.7e-03 | -6.6 | -6.7 | 2.1e-11 | 0.85 | 0.04 | 0.80 | FALSE |
| 8 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | LAYN | 0.13 | 0.07 | enet | 8 | 0.07 | 9.9e-04 | -5.8 | -6.5 | 6.8e-11 | 0.77 | 0.02 | 0.67 | FALSE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SIK2 | 0.05 | 0.06 | lasso | 1 | 0.05 | 2.6e-06 | -6.5 | -6.5 | 8.2e-11 | 0.88 | 0.13 | 0.87 | FALSE |