Best TWAS P=4.46e-11 · Best GWAS P=8.41e-09 conditioned to 0.274
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | STAR | 0.05 | 0.00 | blup | 247 | 0.02 | 1.2e-03 | -5.0 | -5.1 | 2.7e-07 | 0.73 | 0.07 | 0.80 | FALSE |
2 | GTEx | Adrenal Gland | DDHD2 | 0.25 | 0.21 | lasso | 2 | 0.19 | 1.7e-07 | -5.5 | -5.6 | 2.5e-08 | 0.96 | 0.04 | 0.96 | FALSE |
3 | GTEx | Adrenal Gland | LSM1 | 0.17 | 0.10 | enet | 22 | 0.17 | 1.1e-06 | -5.3 | 5.3 | 1.4e-07 | -0.82 | 0.04 | 0.94 | FALSE |
4 | GTEx | Adrenal Gland | RP11-90P5.2 | 0.18 | 0.18 | enet | 24 | 0.22 | 2.0e-08 | -5.2 | 5.1 | 2.6e-07 | -0.76 | 0.05 | 0.93 | FALSE |
5 | GTEx | Artery Tibial | DDHD2 | 0.07 | 0.07 | lasso | 2 | 0.05 | 7.3e-05 | -5.5 | -5.5 | 3.9e-08 | 0.96 | 0.04 | 0.96 | FALSE |
6 | GTEx | Brain Cerebellum | DDHD2 | 0.18 | 0.05 | lasso | 7 | 0.05 | 1.5e-02 | -5.7 | -5.4 | 5.7e-08 | 0.81 | 0.04 | 0.87 | FALSE |
7 | GTEx | Breast Mammary Tissue | RP11-350N15.5 | 0.08 | 0.03 | enet | 12 | 0.02 | 1.9e-02 | -3.9 | 5.3 | 9.5e-08 | -0.90 | 0.04 | 0.88 | FALSE |
8 | GTEx | Breast Mammary Tissue (Female) | RP11-350N15.5 | 0.12 | 0.10 | lasso | 2 | 0.07 | 3.9e-03 | -5.6 | 5.7 | 1.1e-08 | -0.97 | 0.04 | 0.81 | FALSE |
9 | GTEx | Colon Sigmoid | DDHD2 | 0.15 | 0.15 | lasso | 3 | 0.12 | 7.5e-05 | -5.7 | -5.7 | 1.2e-08 | 0.93 | 0.04 | 0.92 | FALSE |
10 | GTEx | Esophagus Mucosa | DDHD2 | 0.09 | 0.02 | lasso | 3 | 0.02 | 8.4e-03 | -5.4 | -5.3 | 1.2e-07 | 0.84 | 0.04 | 0.89 | FALSE |
11 | GTEx | Esophagus Muscularis | DDHD2 | 0.12 | 0.13 | lasso | 2 | 0.12 | 5.7e-08 | -5.2 | -5.3 | 1.5e-07 | 0.91 | 0.07 | 0.93 | FALSE |
12 | GTEx | Pituitary | DDHD2 | 0.25 | 0.22 | lasso | 3 | 0.17 | 3.9e-05 | -5.6 | -5.3 | 1.2e-07 | 0.89 | 0.04 | 0.90 | FALSE |
13 | GTEx | Prostate | DDHD2 | 0.38 | 0.18 | lasso | 7 | 0.17 | 5.4e-05 | -5.3 | -5.8 | 5.8e-09 | 0.91 | 0.05 | 0.94 | FALSE |
14 | GTEx | Spleen | DDHD2 | 0.17 | 0.17 | lasso | 2 | 0.11 | 7.8e-04 | -5.5 | -5.6 | 2.8e-08 | 0.95 | 0.04 | 0.88 | FALSE |
15 | GTEx | Stomach | DDHD2 | 0.13 | 0.06 | lasso | 2 | 0.06 | 1.1e-03 | -5.6 | -5.6 | 2.2e-08 | 0.93 | 0.04 | 0.88 | FALSE |
16 | GTEx | Thyroid | DDHD2 | 0.11 | 0.10 | lasso | 4 | 0.09 | 3.8e-07 | -5.2 | -5.3 | 1.2e-07 | 0.91 | 0.06 | 0.94 | FALSE |
17 | NTR | Blood | BAG4 | 0.01 | 0.01 | blup | 253 | 0.01 | 3.9e-03 | -5.2 | 5.1 | 2.9e-07 | -0.92 | 0.05 | 0.93 | FALSE |
18 | ROSMAP | Brain Pre-frontal Cortex | PPAPDC1B | 0.06 | 0.08 | enet | 14 | 0.09 | 4.0e-11 | -5.7 | -5.7 | 1.0e-08 | 0.97 | 0.04 | 0.96 | FALSE |
19 | ROSMAP | Brain Pre-frontal Cortex | LSM1 | 0.09 | 0.16 | lasso | 6 | 0.16 | 7.3e-20 | -5.4 | 5.4 | 5.1e-08 | -0.93 | 0.11 | 0.89 | FALSE |
20 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DDHD2 | 0.01 | 0.01 | blup | 21 | 0.01 | 2.3e-03 | -5.5 | -6.2 | 4.8e-10 | 0.94 | 0.01 | 0.77 | FALSE |
21 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | BAG4 | 0.04 | 0.03 | lasso | 1 | 0.02 | 1.6e-03 | -5.2 | 5.2 | 1.8e-07 | -0.84 | 0.04 | 0.57 | FALSE |
22 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DDHD2 | 0.03 | 0.03 | blup | 21 | 0.03 | 3.5e-04 | -5.5 | -6.0 | 1.8e-09 | 0.95 | 0.02 | 0.98 | FALSE |
23 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PPAPDC1B | 0.02 | 0.00 | blup | 18 | 0.01 | 4.2e-02 | -5.4 | -6.6 | 4.5e-11 | 0.93 | 0.01 | 0.53 | TRUE |
24 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | DDHD2 | 0.07 | 0.05 | blup | 21 | 0.05 | 2.7e-03 | -5.7 | -5.9 | 3.0e-09 | 0.94 | 0.02 | 0.78 | FALSE |
25 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | PPAPDC1B | 0.14 | 0.06 | enet | 15 | 0.08 | 2.7e-04 | -5.7 | -5.8 | 5.3e-09 | 0.72 | 0.01 | 0.90 | FALSE |
26 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DDHD2 | 0.11 | 0.08 | lasso | 3 | 0.08 | 1.9e-08 | -5.7 | -5.7 | 1.4e-08 | 0.93 | 0.01 | 0.99 | FALSE |
27 | The Cancer Genome Atlas | Thyroid Carcinoma | DDHD2 | 0.02 | 0.01 | blup | 21 | 0.01 | 2.4e-02 | -5.7 | -5.6 | 2.6e-08 | 0.95 | 0.01 | 0.77 | FALSE |