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chr8:37,329,315-38,932,193

Best TWAS P=4.46e-11 · Best GWAS P=8.41e-09 conditioned to 0.274

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
23	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PPAPDC1B	0.02	0.00	blup	18	0.01	4.2e-02	-5.4	-6.6	4.5e-11	0.93	0.01	0.53	TRUE
20	The Cancer Genome Atlas	Breast Invasive Carcinoma	DDHD2	0.01	0.01	blup	21	0.01	2.3e-03	-5.5	-6.2	4.8e-10	0.94	0.01	0.77	FALSE
22	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DDHD2	0.03	0.03	blup	21	0.03	3.5e-04	-5.5	-6.0	1.8e-09	0.95	0.02	0.98	FALSE
24	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	DDHD2	0.07	0.05	blup	21	0.05	2.7e-03	-5.7	-5.9	3.0e-09	0.94	0.02	0.78	FALSE
25	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PPAPDC1B	0.14	0.06	enet	15	0.08	2.7e-04	-5.7	-5.8	5.3e-09	0.72	0.01	0.90	FALSE
13	GTEx	Prostate	DDHD2	0.38	0.18	lasso	7	0.17	5.4e-05	-5.3	-5.8	5.8e-09	0.91	0.05	0.94	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	PPAPDC1B	0.06	0.08	enet	14	0.09	4.0e-11	-5.7	-5.7	1.0e-08	0.97	0.04	0.96	FALSE
8	GTEx	Breast Mammary Tissue (Female)	RP11-350N15.5	0.12	0.10	lasso	2	0.07	3.9e-03	-5.6	5.7	1.1e-08	-0.97	0.04	0.81	FALSE
9	GTEx	Colon Sigmoid	DDHD2	0.15	0.15	lasso	3	0.12	7.5e-05	-5.7	-5.7	1.2e-08	0.93	0.04	0.92	FALSE
26	The Cancer Genome Atlas	Prostate Adenocarcinoma	DDHD2	0.11	0.08	lasso	3	0.08	1.9e-08	-5.7	-5.7	1.4e-08	0.93	0.01	0.99	FALSE
15	GTEx	Stomach	DDHD2	0.13	0.06	lasso	2	0.06	1.1e-03	-5.6	-5.6	2.2e-08	0.93	0.04	0.88	FALSE
2	GTEx	Adrenal Gland	DDHD2	0.25	0.21	lasso	2	0.19	1.7e-07	-5.5	-5.6	2.5e-08	0.96	0.04	0.96	FALSE
27	The Cancer Genome Atlas	Thyroid Carcinoma	DDHD2	0.02	0.01	blup	21	0.01	2.4e-02	-5.7	-5.6	2.6e-08	0.95	0.01	0.77	FALSE
14	GTEx	Spleen	DDHD2	0.17	0.17	lasso	2	0.11	7.8e-04	-5.5	-5.6	2.8e-08	0.95	0.04	0.88	FALSE
5	GTEx	Artery Tibial	DDHD2	0.07	0.07	lasso	2	0.05	7.3e-05	-5.5	-5.5	3.9e-08	0.96	0.04	0.96	FALSE
19	ROSMAP	Brain Pre-frontal Cortex	LSM1	0.09	0.16	lasso	6	0.16	7.3e-20	-5.4	5.4	5.1e-08	-0.93	0.11	0.89	FALSE
6	GTEx	Brain Cerebellum	DDHD2	0.18	0.05	lasso	7	0.05	1.5e-02	-5.7	-5.4	5.7e-08	0.81	0.04	0.87	FALSE
7	GTEx	Breast Mammary Tissue	RP11-350N15.5	0.08	0.03	enet	12	0.02	1.9e-02	-3.9	5.3	9.5e-08	-0.90	0.04	0.88	FALSE
10	GTEx	Esophagus Mucosa	DDHD2	0.09	0.02	lasso	3	0.02	8.4e-03	-5.4	-5.3	1.2e-07	0.84	0.04	0.89	FALSE
12	GTEx	Pituitary	DDHD2	0.25	0.22	lasso	3	0.17	3.9e-05	-5.6	-5.3	1.2e-07	0.89	0.04	0.90	FALSE
16	GTEx	Thyroid	DDHD2	0.11	0.10	lasso	4	0.09	3.8e-07	-5.2	-5.3	1.2e-07	0.91	0.06	0.94	FALSE
3	GTEx	Adrenal Gland	LSM1	0.17	0.10	enet	22	0.17	1.1e-06	-5.3	5.3	1.4e-07	-0.82	0.04	0.94	FALSE
11	GTEx	Esophagus Muscularis	DDHD2	0.12	0.13	lasso	2	0.12	5.7e-08	-5.2	-5.3	1.5e-07	0.91	0.07	0.93	FALSE
21	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	BAG4	0.04	0.03	lasso	1	0.02	1.6e-03	-5.2	5.2	1.8e-07	-0.84	0.04	0.57	FALSE
4	GTEx	Adrenal Gland	RP11-90P5.2	0.18	0.18	enet	24	0.22	2.0e-08	-5.2	5.1	2.6e-07	-0.76	0.05	0.93	FALSE
1	CommonMind	Brain Pre-frontal Cortex	STAR	0.05	0.00	blup	247	0.02	1.2e-03	-5.0	-5.1	2.7e-07	0.73	0.07	0.80	FALSE
17	NTR	Blood	BAG4	0.01	0.01	blup	253	0.01	3.9e-03	-5.2	5.1	2.9e-07	-0.92	0.05	0.93	FALSE