Hub : Genes

BAG4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Whole Blood	0.1040	0.0380	0.00016	0.016	NA	0.029	NA	0.017	0.01300	NA	0.00097	NA	0.0089
2	NTR	Blood	0.0097	0.0047	0.00400	0.010	0.006	0.002	0.006	0.003	0.00030	0.0039	0.08300	0.004	0.0210
3	YFS	Blood	0.0108	0.0057	0.00700	0.010	0.003	0.000	0.003	0.002	0.00027	0.0400	0.28000	0.026	0.0870
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.0443	0.0316	0.00250	0.034	0.006	0.003	NA	0.021	0.00010	0.0590	0.15000	NA	0.0016

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	8.5	13.5	17.9	-3.1	4.2	-3.4	3.9
Bipolar Disorder or Schizophrenia	9.1	22.1	27.2	-3.7	5.1	-4.6	5.2
Depressed Affect (Nagel 2018)	0.1	0.1	0.4	-0.1	-0.3	0.6	-0.3
Depression (Nagel 2018)	0.2	0.2	0.4	0.2	-0.6	0.4	-0.6
Intelligence (Savage-Jansen 2018)	1.0	3.2	5.0	-1.7	1.7	-2.2	1.4
Neuroticism (Nagel 2018)	1.1	2.6	4.0	-1.3	2.0	-1.3	1.7
Schizophrenia (2018)	4.5	9.4	12.6	-2.3	3.3	-3.0	3.6
Schizophrenia vs Biploar Disorder	0.2	0.3	0.6	-0.5	0.0	-0.8	0.6
Worry (Nagel 2018)	1.4	3.0	6.5	-0.9	2.5	-1.3	1.8
Alzheimer’s Disease (in mother)	0.7	0.9	1.7	1.3	-1.1	-0.4	-0.7
Alzheimer’s Disease (in father)	0.3	0.3	0.7	-0.5	0.2	0.3	0.9
Alzheimer’s Disease (including proxy)	0.1	0.1	0.3	0.3	-0.2	-0.1	0.6
Crohns Disease (2017)	0.9	2.0	3.8	-0.8	1.7	-2.0	0.8
Irritable Bowel Disease (IBD)	1.7	4.1	7.4	-0.9	2.5	-2.7	1.3
Ulcerative Colitis (UC)	1.4	2.7	5.2	-0.8	2.0	-2.3	1.1
Major Depression (MDD)	0.9	1.1	1.9	-0.2	1.4	-1.1	1.2
Reaction Time	0.1	0.3	0.6	0.8	0.6	0.2	-0.1
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.5	0.2	0.2	-1.2	0.1
Breast Cancer	0.1	0.3	0.5	0.7	0.3	-0.7	0.1
Ovarian Cancer	0.1	0.1	0.2	-0.2	0.4	-0.2	0.4
Prostate Cancer	0.2	0.3	0.5	-0.6	0.1	0.7	-0.6
Age at First Birth	0.9	1.3	2.7	0.3	-1.3	0.8	-1.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.6	0.8	2.5	-1.6	0.6	-0.5	0.0
Coronary Artery Disease (CAD)	0.4	0.4	1.0	1.0	0.5	-0.7	0.0
Crohns Disease (2012)	1.4	2.2	3.8	-1.9	1.3	-1.6	1.0
Mean Putamen Volume	4.5	5.2	10.8	-2.1	3.3	-1.5	1.7
Fasting Glucose	0.9	1.1	3.0	1.7	-0.3	0.2	-1.1
HbA1C	0.2	0.3	0.5	0.3	-0.7	-0.5	-0.5
HDL Cholesterol	0.0	0.1	0.3	-0.2	0.1	-0.5	0.0
LDL Cholesterol	0.2	0.3	0.8	-0.4	-0.9	0.2	0.0
Lupus	1.1	1.7	3.2	-0.9	1.2	-1.8	1.1
Neuroticism (2016)	0.5	0.8	2.1	-0.5	1.4	-0.3	0.8
Primary Biliary Cirrhosis	0.1	0.1	0.2	-0.4	-0.5	-0.1	0.2
Rheumatoid Arthritis	2.3	3.2	5.1	-1.7	1.4	-1.7	2.3
Schizophrenia (2014)	4.8	10.7	13.6	-2.4	3.7	-3.4	3.5
Triglycerides	0.2	0.3	1.3	-1.1	-0.2	-0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.5	0.3	0.8	-1.2	0.0
Ulcerative Colitis	2.4	3.4	4.7	-1.6	2.0	-2.2	1.5
Blood Eosinophil Count	0.1	1.1	4.3	2.1	-0.1	-0.1	0.1
Blood Platelet Count	0.1	1.1	2.5	-0.7	-0.5	1.6	-1.0
Blood Red Count	0.5	4.6	5.9	-1.3	2.3	-2.3	2.4
Blood White Count	0.5	3.8	5.6	1.5	-2.4	2.0	-1.9
Heel T-Score	0.8	6.4	13.2	3.6	-3.0	1.1	-1.5
BMI	0.5	2.9	4.9	-0.7	2.2	-2.1	1.3
Height	1.5	29.5	47.3	-3.7	6.9	-6.1	4.4
Waist Hip Ratio (WHR)	0.1	0.4	0.9	-0.2	-0.4	0.9	0.7
Systolic Blood Pressure	8.7	43.5	52.4	5.6	-7.2	7.1	-6.3
Smoking Status	2.6	6.2	10.7	-1.5	1.6	-3.0	3.3
Allergy or Eczema	4.4	11.6	13.7	3.7	-3.4	3.7	-2.8
Cardiovascular Disease	1.5	5.0	5.8	2.0	-2.4	2.3	-2.2
Hypothyroidism (self reported)	3.5	8.1	12.7	-1.9	3.6	-3.4	2.2
Respiratory disease	0.4	0.9	1.6	1.2	-1.3	0.9	0.1
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.3	-0.3	-0.2	-0.5	-0.3
Lung FEV1/FVC ratio	0.4	1.9	3.5	-1.9	1.1	-1.1	1.3
Lung FVC	3.9	20.1	29.0	3.0	-4.2	5.4	-5.0
Neuroticism	1.2	2.8	5.8	-1.0	2.4	-1.0	1.8
Chronotype (morning person)	0.1	0.2	0.6	0.2	0.4	0.7	-0.2
Hair Pigment	0.0	1.0	2.2	-0.3	1.5	-1.0	0.7
Tanning	0.4	4.9	7.1	1.4	-2.0	2.7	-2.5
Hand grip strength (left)	0.2	0.6	1.3	-0.7	0.6	-1.1	0.4
Number of treatments/medications taken	0.8	1.4	2.2	1.5	-1.3	0.6	-1.0
Average weekly spirits intake	10.6	13.1	17.6	-3.3	4.2	-2.8	4.0
Sensitivity / hurt feelings	0.4	0.6	1.5	-1.2	0.8	0.2	0.5
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.5	0.3	-0.5	0.7	-0.7
Hearing difficulty/problems: Yes	8.6	13.1	15.6	-3.8	4.0	-3.1	3.5
Relative age of first facial hair	0.2	0.3	1.1	1.0	-0.3	-0.4	0.2
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	1.0	-1.0	-0.1	-1.0	0.5
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.2	-1.0	0.0	-0.4	1.5
Ever had hysterectomy (womb removed)	0.9	1.0	2.0	-1.4	1.1	-0.4	0.8
Systolic blood pressure, automated reading	4.1	11.9	16.1	2.7	-4.0	3.9	-2.9
Eye problems/disorders: Diabetes related eye disease	2.6	2.8	6.1	2.5	-0.7	1.5	-1.6
Angina	0.9	1.1	4.1	2.0	-0.4	-0.4	-0.3
Medication for hormone replacement therapy	1.6	1.8	4.7	-0.4	0.6	-1.4	2.2
Vitamin and mineral supplements	0.6	0.9	2.2	0.3	-0.8	1.5	-0.7
Supplements: Zinc	1.3	1.4	3.3	-1.4	0.2	-1.8	0.6
Medication: Co-codamol	0.3	0.4	1.2	0.3	-0.4	1.1	-0.3
Medication: Metformin	0.3	0.4	1.3	0.4	0.1	-1.1	0.0
Diabetes (father)	1.4	1.7	3.4	0.8	-1.8	1.3	-1.1
Diabetes (mother)	0.4	0.5	0.9	-0.9	-0.4	-0.8	0.6
Severe depression (siblings)	0.6	0.7	1.6	-0.3	1.3	-0.8	0.6
Pack years adult smoking proportion	0.7	1.1	2.4	-0.8	0.2	-1.2	1.6
Impedance of leg (right)	6.4	30.8	37.1	4.6	-6.1	6.1	-5.3
Leg fat-free mass (left)	4.1	21.6	31.4	-3.0	5.3	-5.6	4.2
Trunk fat percentage	0.5	2.1	5.4	2.3	-0.9	0.6	-1.4
Hand grip strength (right)	0.5	1.4	2.9	-0.6	1.4	-1.7	0.7
Townsend deprivation index at recruitment	0.4	0.5	1.4	-1.2	-0.1	0.9	-0.1
Current tobacco smoking	1.6	2.7	3.8	-1.5	1.4	-1.6	1.9
Average weekly fortified wine intake	0.1	0.1	0.4	-0.6	0.4	-0.2	0.0
Maternal smoking around birth	0.6	0.9	1.7	-1.3	1.2	0.2	0.6
Fed-up feelings	1.1	2.0	3.8	0.3	-1.1	1.9	-1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.1	-0.2	-0.0	-0.0	0.2
Relative age voice broke	0.0	0.0	0.0	0.2	0.2	-0.2	-0.1
Taking other prescription medications	0.8	1.2	3.4	0.1	1.0	-1.8	0.6
Age when periods started (menarche)	0.5	1.3	2.2	0.6	-1.5	1.0	-1.2
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.5	-1.2	0.1	0.2	0.3
Heel bone mineral density (BMD) T-score, automated (left)	2.0	4.4	7.7	1.8	-2.8	0.9	-2.4
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.6	-0.1	-0.9	1.3	-0.3
Qualifications: CSEs or equivalent	2.6	3.5	6.5	1.6	-1.5	1.6	-2.5
Serious illness, injury or assault to yourself	0.1	0.1	0.3	-0.2	-0.6	0.5	-0.1
High blood pressure	1.5	4.1	5.7	1.4	-2.0	2.2	-2.4
Hayfever, allergic rhinitis or eczema	3.1	6.8	7.9	2.8	-2.3	2.7	-2.7
Multivitamins +/- minerals	0.8	1.0	2.0	-0.3	1.1	-1.4	0.8
Stomach or abdominal pain in last month	1.6	2.0	3.6	-1.1	1.3	-1.9	1.1
Supplements: Glucosamine	4.1	5.3	7.0	2.7	-2.5	1.7	-2.2
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.6	-0.8	-0.2	0.1	-0.3
Medication: Atenolol	1.7	2.2	2.9	1.2	-1.7	1.5	-1.4
Medication: Levothyroxine sodium	3.5	6.0	11.8	-1.5	2.3	-3.4	2.1
Sitting height	0.1	0.6	0.9	0.9	-0.6	-0.3	-1.0
Chronic bronchitis/emphysema (father)	0.4	0.5	0.8	-0.2	0.8	-0.9	0.8
High blood pressure (mother)	4.8	6.7	14.0	1.9	-1.8	3.7	-2.4
Body mass index (BMI)	0.5	2.2	3.6	-0.7	1.8	-1.9	1.2
Impedance of leg (left)	5.6	27.0	35.2	4.2	-5.7	5.9	-4.8
Leg predicted mass (left)	4.1	21.7	31.4	-3.0	5.3	-5.6	4.3
Trunk fat mass	0.2	0.6	1.0	1.0	0.8	-1.0	-0.1
Waist circumference	0.7	2.6	3.8	-1.0	1.9	-1.7	1.6
Number of incorrect matches in round	0.3	0.4	0.7	0.9	0.8	-0.3	-0.4
Past tobacco smoking	0.9	1.6	3.3	0.1	0.2	1.7	-1.8
Alcohol usually taken with meals	2.0	3.2	6.0	0.7	-2.4	1.6	-2.0
Nervous feelings	0.1	0.2	0.3	0.5	0.5	0.3	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.2	0.4	-0.0	0.6	-0.6	0.5
Hearing difficulty/problems with background noise	5.5	8.7	9.4	-2.9	3.1	-2.8	3.0
Hair/balding pattern: Pattern 2	1.5	1.9	2.9	1.2	-1.7	1.3	-1.2
Had menopause	0.8	1.0	2.2	-0.2	-1.2	0.4	1.5
Had other major operations	0.3	0.4	1.4	0.1	-1.2	-0.2	-0.1
Forced vital capacity (FVC)	0.7	2.7	6.4	1.1	-1.0	1.5	-2.5
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	5.6	1.1	-2.4	0.6	-1.7
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.1	0.3	-0.2	0.3	-0.1
Qualifications: None of the above	0.1	0.2	0.6	0.8	-0.4	0.0	-0.1
Financial difficulties in last 2 years	0.4	0.6	1.5	1.2	-0.7	-0.3	-0.4
Mouth/teeth dental problems	0.4	0.7	1.8	1.4	-0.2	-0.3	-0.9
Heart attack	0.6	0.8	2.9	1.7	0.3	0.2	0.2
Allergy	1.4	3.3	4.1	-2.0	2.0	-1.6	1.6
Pain all over the body in last month	1.0	1.0	2.1	1.4	-0.7	0.2	-1.3
Diabetes (self-reported)	1.1	1.7	3.3	-0.8	1.4	-1.8	1.0
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.4	0.5	-0.3	0.6	-1.2
Medication: Ramipril	2.2	2.9	4.4	1.4	-2.1	1.5	-1.7
Medication: Simvastatin	0.9	1.4	2.9	1.7	-0.9	-0.5	-1.3
Fluid intelligence score	0.4	0.8	2.8	0.5	0.1	-1.7	0.2
Illnesses of siblings	0.4	0.5	2.0	1.4	0.1	-0.3	-0.2
Neuroticism score	1.1	2.4	3.9	-1.7	2.0	-0.9	1.4
Weight	1.5	7.4	12.2	-1.5	3.2	-3.5	2.2
Impedance of arm (right)	2.9	13.6	17.4	3.5	-4.2	3.7	-3.4
Arm fat percentage (right)	0.1	0.5	1.5	1.2	-0.2	-0.0	-0.8
Trunk fat-free mass	4.1	23.5	31.0	-3.8	5.4	-5.6	4.4
Hip circumference	0.8	3.5	7.0	-0.6	2.1	-2.6	1.6
Time employed in main current job	0.2	0.3	0.6	0.4	-0.1	-0.8	-0.5
Alcohol intake versus 10 years previously	0.4	0.6	1.6	-0.3	0.3	-0.7	1.3
Father’s age at death	0.5	0.6	1.3	1.1	-0.5	1.0	-0.3
Worrier / anxious feelings	0.4	0.8	1.8	-1.4	1.1	-0.0	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.4	-0.3	0.2	-0.6	0.3
Falls in the last year	0.8	1.1	2.0	-1.3	1.4	-0.4	0.8
Hair/balding pattern: Pattern 3	1.4	2.1	4.3	-0.8	2.1	-1.7	0.7
Number of live births	0.0	0.0	0.1	-0.3	0.1	0.3	0.1
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	4.8	0.8	-0.8	1.3	-2.2
Pulse rate	1.0	1.7	3.0	-1.7	-1.0	1.7	-0.2
Happiness	1.6	1.9	3.5	-0.0	-1.5	1.9	-1.4
Noisy workplace	1.4	1.7	2.5	-1.6	0.9	-1.1	1.6
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.0	0.6	-0.5	1.0	-0.5
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	2.6	0.7	-0.9	1.6	-1.2
Mouth/teeth dental problems: Dentures	0.4	0.7	1.4	-1.2	-0.5	-0.1	1.2
Asthma	1.0	2.0	4.6	1.8	-2.1	0.3	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	2.3	1.5	-0.7	-0.0	-0.8
Medication: Cholesterol lowering	0.5	0.8	1.9	1.4	-0.3	-0.6	-0.8
Depression (self-reported)	0.2	0.2	0.4	0.2	0.3	0.6	-0.5
Medication: Lansoprazole	0.3	0.4	0.9	0.7	-0.4	-0.9	0.2
Prospective memory result	0.1	0.1	0.4	0.2	0.1	0.6	0.1
Lung cancer (father)	0.8	1.0	1.4	-0.9	1.2	-1.2	0.5
Illnesses of mother	8.0	9.9	13.5	-2.5	3.3	-3.7	3.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.8	2.1	0.5	-0.4	0.8	-1.4
Pulse wave Arterial Stiffness index	1.2	1.4	2.8	-1.7	1.3	-0.9	0.6
Impedance of arm (left)	3.6	16.5	19.2	4.0	-4.4	3.9	-4.0
Arm fat mass (right)	0.4	1.6	3.3	-0.2	1.6	-1.8	0.9
Trunk predicted mass	4.0	23.1	30.1	-3.8	5.4	-5.5	4.3
Standing height	0.9	8.7	14.7	-1.5	3.4	-3.8	2.5
Length of working week for main job	0.2	0.2	0.5	0.2	0.6	-0.2	0.7
Exposure to tobacco smoke at home	0.5	0.6	1.4	-0.3	-0.3	-1.2	0.7
Breastfed as a baby	1.7	2.1	4.2	2.0	-1.2	0.8	-1.5
Tense / ‘highly strung’	3.9	6.5	13.7	-1.4	3.7	-2.3	2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	2.0	-0.3	1.4	-0.6	0.7
Hair/balding pattern: Pattern 4	0.2	0.6	2.1	-0.2	-1.4	-0.4	0.1
Birth weight of first child	0.7	1.2	1.9	1.1	0.3	1.4	-1.2
Peak expiratory flow (PEF)	0.7	1.7	2.4	-1.0	1.3	-1.4	1.5
Pulse wave reflection index	0.6	0.8	1.8	-0.8	1.4	-0.7	0.5
Ever highly irritable/argumentative for 2 days	4.8	5.7	8.2	-2.9	1.7	-2.5	2.4
Loud music exposure frequency	0.6	0.7	1.9	1.4	-0.8	0.3	-0.4
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	1.4	0.9	-1.2	0.8	-1.1
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.5	-0.7	-0.2	0.3	-0.6
Blood clot in the leg (DVT)	0.6	0.8	1.1	-1.1	0.5	-0.8	1.0
Medication: Paracetamol	1.4	2.3	4.4	0.7	-2.1	1.8	-1.0
Headache pain in last month	1.2	2.1	3.0	-1.6	0.9	-1.7	1.5
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	4.6	-1.7	1.1	-0.6	2.2
Glaucoma (self-reported)	0.7	0.8	1.7	1.3	-0.8	1.0	-0.3
Gout (self-reported)	1.0	1.3	2.8	-1.0	1.1	-0.6	1.7
Hypothyroidism/myxoedema (self-reported)	3.9	7.6	11.9	-1.8	3.3	-3.5	2.1
Medication: Amlodipine	3.9	5.5	7.0	2.3	-2.5	2.6	-1.9
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.0	0.1	0.1	-0.1	0.0
Birth weight	0.2	0.4	1.1	-0.6	1.1	0.3	-0.4
Chronic bronchitis/emphysema (mother)	1.4	1.6	3.6	-0.7	-1.3	1.9	-0.8
High blood pressure (siblings)	0.7	1.0	2.3	-1.0	-0.8	1.5	-0.2
Forced vital capacity (FVC), Best measure	0.2	0.7	2.1	0.3	-0.4	0.7	-1.4
Body fat percentage	0.7	2.8	5.7	2.4	-1.3	1.1	-1.6
Leg fat percentage (right)	0.9	3.2	3.6	1.9	-1.7	1.6	-1.9
Arm fat-free mass (right)	3.5	17.9	24.0	-3.0	4.9	-4.9	3.9
Exposure to tobacco smoke outside home	0.5	0.7	1.6	-0.8	1.3	-0.4	0.6
Comparative body size at age 10	1.9	5.3	8.0	-1.6	2.2	-2.3	2.8
Number of full brothers	0.3	0.3	0.7	-0.8	0.6	-0.5	-0.2
Worry too long after embarrassment	5.0	8.3	11.5	-2.4	3.4	-2.7	2.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.7	-0.2	1.3	-1.1	0.3
Wheeze or whistling in the chest in last year	0.3	0.4	1.0	-0.1	0.4	-0.8	1.0
Number of children fathered	0.2	0.2	0.2	0.4	0.4	-0.5	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.5	-0.6	0.3	0.2	-0.7
Age at first live birth	0.9	1.6	2.8	1.7	-1.4	0.3	-1.3
Pulse wave peak to peak time	1.2	1.4	2.9	1.7	-1.3	0.8	-0.5
Health satisfaction	0.4	0.5	1.0	-1.0	0.1	1.0	-0.1
Shortness of breath walking on level ground	0.5	0.6	1.5	-1.2	-0.1	-0.3	1.0
Qualifications: College or University degree	1.1	3.6	5.3	-1.3	2.3	-2.0	1.9
Eye problems/disorders: None of the above	1.1	1.3	2.5	-1.6	0.7	-0.9	1.1
Mouth/teeth dental problems: Loose teeth	0.9	1.1	2.5	-1.6	0.9	0.1	1.1
Emphysema/chronic bronchitis	0.9	1.0	1.9	-0.6	0.9	-1.0	1.4
Medication for pain relief, constipation, heartburn	1.5	2.6	3.7	-1.2	1.9	-1.7	1.5
Neck or shoulder pain in last month	0.5	0.7	2.1	0.6	-1.4	0.5	-0.5
Medication: Blood pressure	3.8	6.7	9.6	2.0	-2.6	2.5	-3.1
Angina (self-reported)	0.8	1.0	3.7	1.9	-0.4	-0.3	-0.2
Migraine (self-reported)	0.4	0.4	1.0	-0.6	0.2	-1.0	0.6
Medication: Ibuprofen	0.4	0.4	1.6	1.3	0.0	-0.4	-0.2
Medication: Allopurinol	1.8	2.3	3.2	-1.4	1.8	-1.4	1.6
Medication: Omeprazole	0.4	0.5	0.6	0.5	-0.8	0.6	-0.8
Medication: Seretide 50 evohaler	5.7	6.6	10.3	2.1	-3.2	2.7	-2.1
Mean time to correctly identify matches	0.4	0.7	1.6	0.3	1.3	-0.6	0.8
Heart disease (mother)	5.5	6.7	10.8	2.2	-3.3	2.6	-2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.8	0.5	0.5	-0.9	0.1
Whole body fat mass	0.1	0.6	1.0	0.7	0.9	-1.0	0.3
Leg fat mass (right)	0.1	0.3	0.6	0.5	0.6	-0.8	0.2
Arm predicted mass (right)	3.1	16.0	21.5	-2.9	4.6	-4.6	3.6
Pulse rate, automated reading	1.1	3.7	8.8	-0.8	-1.9	3.0	-1.3
Alcohol intake frequency.	0.5	1.1	2.7	0.8	-0.5	1.0	-1.6
Comparative height size at age 10	1.0	5.3	10.4	-0.9	2.8	-3.2	1.5
Number of full sisters	0.9	1.1	2.2	-1.5	0.4	-1.4	0.4
Suffer from ‘nerves’	1.5	2.4	3.4	-1.3	1.9	-1.4	1.6
Overall health rating	0.0	0.1	0.4	-0.1	-0.1	0.0	-0.6
Chest pain or discomfort	0.9	1.3	1.5	-0.9	1.2	-1.2	1.1
Had major operations	0.7	0.8	1.6	0.4	0.7	-1.3	1.0
Age at last live birth	0.1	0.2	0.8	0.9	-0.1	-0.1	0.0
Family relationship satisfaction	0.1	0.2	0.5	0.1	-0.4	0.1	-0.7
Leg pain on walking	0.0	0.1	0.2	0.1	0.2	0.4	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	-0.4	0.3	-0.1	0.1
Commuting to job workplace: Car/motor vehicle	6.0	6.8	11.2	-1.2	2.4	-3.3	3.0
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.2	-0.9	1.1	-0.3	0.4
Medication: Aspirin	0.2	0.2	0.6	0.5	-0.8	-0.1	-0.1
Supplements: Vitamin C	0.1	0.1	0.2	0.4	-0.3	-0.2	-0.3
Knee pain experienced in last month	0.1	0.2	0.4	-0.4	-0.2	0.4	-0.6
Hypertension (Self-reported)	1.5	4.1	5.6	1.3	-2.0	2.3	-2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.5	0.7	-0.5	-0.3	0.4
Illnesses of father: Heart disease	0.2	0.2	0.8	0.2	0.2	-0.9	-0.3
Illnesses of siblings: Diabetes	1.4	1.7	4.8	-2.2	0.5	-0.5	1.3
Smoking status: Previous	0.5	0.7	0.9	0.8	-0.5	-1.0	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	3.5	-0.2	1.9	-0.8	0.7
Whole body fat-free mass	4.4	24.9	33.5	-3.7	5.6	-5.8	4.6
Leg fat-free mass (right)	4.8	25.9	35.5	-3.4	5.8	-6.0	4.8
Arm fat percentage (left)	0.3	1.0	2.7	1.7	-0.4	0.2	-1.1
Average weekly red wine intake	0.9	1.3	3.1	-1.8	0.9	-0.8	0.7
Handedness (chirality/laterality): Left-handed	5.7	6.9	12.1	0.9	-2.8	3.5	-2.6
Mood swings	1.2	2.2	4.5	-2.1	1.5	-0.8	1.3
Loneliness, isolation	1.8	2.5	2.9	1.5	-1.6	1.4	-1.7
Long-standing illness, disability or infirmity	0.0	0.0	0.1	-0.3	-0.3	-0.0	0.1
Ever had bowel cancer screening	3.4	4.0	6.1	-1.1	2.1	-2.5	2.1
Diabetes diagnosed by doctor	0.1	0.2	0.6	-0.0	0.1	-0.8	0.1
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	3.2	1.8	-1.2	1.2	-0.6
Friendships satisfaction	0.8	1.0	2.5	0.4	-0.6	0.9	-1.6
Qualifications: nursing, teaching	2.4	3.7	5.4	0.9	-2.3	2.2	-1.9
Commuting to job workplace: Walk	0.3	0.3	0.5	-0.6	-0.7	0.4	-0.5
Eye problems/disorders: Cataract	3.0	3.5	4.6	1.7	-1.5	2.2	-2.0
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	2.9	-1.7	-0.0	0.8	-0.1
Medication for cholesterol	0.4	0.6	1.2	-0.6	1.1	-0.5	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.0	-0.2	-0.3	0.4	-1.0
Back pain experienced in last month	5.1	7.5	11.5	1.6	-3.4	2.8	-2.9
Mineral and other dietary supplements	2.0	2.6	4.0	-1.8	2.0	-0.6	1.7
Breast cancer (self-reported)	0.2	0.2	0.6	-0.8	0.2	0.5	0.2
Asthma (self-reported)	1.1	2.2	5.0	1.8	-2.2	0.6	-0.4
Osteoporosis (self-reported)	0.3	0.4	0.5	-0.7	0.6	-0.5	0.7
Osteoarthritis (self-reported)	0.1	0.1	0.2	-0.4	-0.1	-0.3	-0.0
Medication: Aspirin	0.0	0.0	0.1	0.3	-0.1	-0.1	0.0
Medication: Gliclazide	0.4	0.4	0.6	0.6	0.8	-0.7	0.5
Illnesses of father: None of the above (group 1)	0.4	0.5	1.9	-0.2	1.4	-0.2	0.3
Smoking status: Current	1.5	2.5	3.4	-1.5	1.2	-1.7	1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.8	5.0	0.8	-1.4	1.9	-2.2
Whole body water mass	4.4	25.2	34.5	-3.7	5.7	-5.9	4.6
Leg predicted mass (right)	4.8	25.7	34.8	-3.5	5.8	-5.9	4.7
Arm fat mass (left)	0.3	1.2	2.6	-0.1	1.4	-1.6	0.6
Number of self-reported non-cancer illnesses	0.1	0.1	0.2	0.4	-0.2	-0.4	0.0
Average weekly champagne plus white wine intake	0.8	1.1	2.7	-1.6	0.5	-0.5	1.1
Miserableness	0.2	0.3	0.6	-0.8	0.4	0.0	0.7
Guilty feelings	3.9	5.9	11.0	-3.3	2.3	-2.0	1.8
Wears glasses or contact lenses	3.4	3.9	7.7	1.2	-2.8	1.9	-1.6
Ever taken oral contraceptive pill	0.7	0.8	2.0	-1.4	0.7	0.3	0.6
Hearing aid user	0.4	0.4	1.2	0.0	1.1	-0.2	0.6
Mother’s age at death	0.1	0.1	0.2	-0.1	-0.1	0.2	0.5
Financial situation satisfaction	1.8	2.2	3.1	1.0	-1.7	1.8	-1.3
Tinnitus: Yes, now most or all of the time	1.0	1.2	2.2	-0.7	1.2	-1.5	0.8
Commuting to job workplace: Public transport	3.9	4.7	6.2	1.5	-2.5	2.5	-2.1
Eye problems/disorders: Glaucoma	1.1	1.2	3.3	1.8	-0.3	0.9	-0.9
Medication: Blood pressure	1.8	3.4	5.5	0.5	-2.3	2.4	-1.6
Pain type(s) experienced in last month: Hip pain	3.9	4.9	7.1	-2.7	1.9	-2.1	2.1
Supplements: Fish oil (including cod liver oil)	1.0	1.3	2.7	1.0	-1.7	0.3	-1.2
High cholesterol (Self-reported)	0.3	0.5	0.8	0.9	-0.7	-0.3	-0.7
Medication: Bendroflumethiazide	3.9	5.8	8.4	1.0	-2.9	2.8	-2.5
Medication: Paracetamol	1.9	3.0	5.6	1.3	-2.4	1.7	-1.3
Medication: Lisinopril	0.9	1.2	2.0	0.3	-1.4	1.4	-0.8
Medication: Atorvastatin	0.2	0.2	0.6	0.5	-0.8	0.1	0.3
Illnesses of father: High blood pressure	0.3	0.3	0.5	-0.5	-0.7	0.3	0.7
Alcohol drinker status: Never	0.2	0.2	0.6	-0.1	0.3	-0.8	-0.4
Ever smoked	2.0	3.4	7.7	-0.9	0.4	-2.2	2.8
Basal metabolic rate	3.5	19.1	27.5	-3.0	5.0	-5.2	3.9
Leg fat percentage (left)	0.6	2.0	2.3	1.5	-1.3	1.3	-1.5
Arm fat-free mass (left)	3.1	15.9	20.6	-3.2	4.5	-4.5	3.5
Number of operations (self-reported)	0.1	0.1	0.3	-0.2	0.0	-0.5	0.5
Average weekly beer plus cider intake	0.2	0.3	0.8	0.4	-0.2	-0.9	0.6
Irritability	3.3	5.5	7.5	-1.8	2.7	-2.7	2.1
Risk taking	6.4	9.4	14.3	-2.3	2.7	-3.8	3.3
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.4	0.5	-0.3	0.7	-0.6
Fractured/broken bones in last 5 years	0.9	1.2	3.4	-1.8	0.9	-0.8	0.2
Age started oral contraceptive pill	1.0	1.2	1.9	0.9	-1.4	1.1	-0.9
Diastolic blood pressure, automated reading	1.1	3.5	7.6	1.0	-2.0	2.8	-1.3
Ever depressed for a whole week	0.1	0.1	0.2	-0.4	-0.3	-0.2	-0.1
Unable to work because of sickness or disability	0.5	0.6	1.5	-0.4	-1.2	-0.9	-0.3
Commuting to job workplace: Cycle	0.5	0.6	1.2	0.1	-1.1	1.0	-0.3
Myopia	2.6	3.8	7.9	0.7	-2.8	2.0	-1.7
Vascular/heart problems diagnosed by doctor	1.4	3.7	4.8	-1.8	1.9	-1.8	2.2
Cholesterol lowering medication	1.1	1.6	3.3	1.7	-1.8	0.2	-0.5
Medication: Omeprazole (e.g. Zanprol)	1.2	1.4	2.1	1.1	-1.5	1.0	-1.2
Pain experienced in last month	0.1	0.1	0.4	0.6	-0.2	0.3	-0.0
Supplements: Calcium	0.5	0.5	1.3	0.3	0.4	-1.2	0.7
Basal cell carcinoma (self-reported)	0.2	0.2	0.7	-0.0	-0.9	0.1	0.2
Heart attack/myocardial infarction (self-reported)	0.4	0.6	2.0	1.4	0.3	0.2	0.3
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.3	-1.1	0.5	-0.5	0.7
Heart disease (siblings)	0.2	0.2	0.5	-0.7	-0.5	0.3	0.2
Alcohol drinker status: Previous	1.0	1.1	2.0	-0.9	1.4	-0.9	0.9
Pack years of smoking	0.7	1.1	2.2	-0.9	0.2	-1.2	1.5
Impedance of whole body	5.3	27.1	32.0	4.6	-5.7	5.5	-5.0
Leg fat mass (left)	0.2	0.6	1.2	0.1	1.1	-1.1	0.5
Arm predicted mass (left)	3.4	17.5	23.1	-3.0	4.8	-4.8	3.9