TWAS hub - PPAPDC1B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0470	0.0270	8.0e-03	0.011	0.013	0.017	0.017	0.009	1.6e-02	9.6e-03	2.9e-03	3.5e-03	2.3e-02
2	GTEx	Artery Tibial	0.0899	0.0429	8.0e-03	-0.003	NA	-0.001	NA	-0.003	8.4e-01	NA	3.9e-01	NA	7.7e-01
3	GTEx	Testis	0.1050	0.0460	5.0e-03	0.024	NA	-0.006	NA	0.067	2.9e-02	NA	8.9e-01	NA	6.6e-04
4	ROSMAP	Brain Pre-frontal Cortex	0.0561	0.0165	1.4e-08	0.082	0.083	0.086	0.085	0.084	1.0e-10	8.4e-11	4.0e-11	4.8e-11	6.0e-11
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0171	0.0156	9.9e-03	0.005	0.008	0.002	NA	0.001	8.3e-02	4.2e-02	1.6e-01	NA	2.2e-01
6	TCGA	Pancreatic Adenocarcinoma	0.1380	0.1550	9.7e-04	0.061	0.067	0.081	NA	0.077	1.5e-03	9.2e-04	2.7e-04	NA	4.0e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	8.1	12.8	26.0	-2.6	0.1	0.0	-4.5	-5.1	-4.9
Bipolar Disorder or Schizophrenia	7.9	19.2	43.4	-2.2	-0.0	0.0	-5.7	-6.6	-5.8
Average weekly spirits intake	7.3	9.1	15.2	-1.1	-1.7	-3.2	-3.9	-3.8	-3.3
Hearing difficulty/problems: Yes	6.5	9.9	15.5	-0.9	-2.6	-2.9	-3.6	-3.9	-3.9
Illnesses of mother	6.2	7.6	13.0	-0.7	-1.8	-2.9	-3.4	-3.6	-3.0
Systolic Blood Pressure	6.1	30.5	56.1	2.0	2.2	5.1	7.3	7.5	6.2
Medication: Seretide 50 evohaler	4.9	5.6	8.5	2.4	-0.4	2.9	2.6	2.8	2.2
Back pain experienced in last month	4.7	6.9	14.3	1.2	0.4	2.2	3.6	3.8	2.8
Impedance of leg (right)	4.6	22.5	39.1	2.1	2.9	5.1	6.2	6.3	4.3
Heart disease (mother)	4.6	5.6	12.1	1.4	1.1	1.3	2.9	3.5	2.9
Impedance of leg (left)	4.4	21.4	37.2	1.7	2.7	5.0	6.1	6.1	4.3
Hearing difficulty/problems with background noise	4.3	6.9	13.6	-0.3	-1.8	-2.7	-3.0	-2.9	-3.7
Worry too long after embarrassment	4.3	7.2	11.9	-2.2	-0.9	-2.8	-3.4	-3.2	-2.8
Handedness (chirality/laterality): Left-handed	4.3	5.1	8.5	1.8	-0.5	2.0	2.9	2.8	2.6
Myopia	4.3	6.2	12.9	2.9	-1.4	1.4	2.3	2.6	3.6
Mean Putamen Volume	4.2	4.8	8.9	0.2	-1.2	-3.0	-3.0	-2.8	-1.4
Commuting to job workplace: Car/motor vehicle	4.2	4.8	7.7	-0.2	0.9	-2.7	-2.6	-2.4	-2.8
Tense / ‘highly strung’	4.1	6.8	12.5	-2.3	0.7	-2.3	-3.5	-3.5	-2.1
Impedance of whole body	4.1	20.7	36.3	1.2	2.3	4.9	5.8	6.0	4.8
Schizophrenia (2014)	4.0	8.8	21.4	-1.3	0.3	0.0	-4.0	-4.6	-3.7
High blood pressure (mother)	3.9	5.4	12.0	-0.3	1.9	3.5	2.5	2.7	1.7
Schizophrenia (2018)	3.7	7.7	18.8	-0.7	-0.1	0.0	-3.7	-4.3	-3.6
Irritability	3.7	6.3	11.4	-1.7	-0.2	-3.4	-3.4	-3.1	-1.6
Risk taking	3.6	5.2	11.9	-0.4	0.3	-2.3	-3.4	-3.2	-2.0
Allergy or Eczema	3.4	9.0	13.1	2.1	3.0	2.5	3.6	3.6	3.0
Leg fat-free mass (right)	3.4	18.0	32.3	-0.9	-2.5	-4.7	-5.5	-5.7	-4.0
Leg predicted mass (right)	3.4	18.0	32.3	-0.9	-2.5	-4.7	-5.5	-5.7	-4.0
Guilty feelings	3.3	5.0	7.6	0.0	-1.9	-2.0	-2.8	-2.7	-2.6
Hypothyroidism/myxoedema (self-reported)	3.2	6.2	14.4	-1.6	-1.0	-1.3	-3.1	-3.8	-2.7
Medication: Amlodipine	3.2	4.5	6.5	1.6	2.5	1.5	2.5	2.6	1.8
Whole body fat-free mass	3.2	18.3	31.9	-0.4	-2.6	-4.7	-5.4	-5.7	-4.5
Whole body water mass	3.2	18.5	32.6	-0.4	-2.6	-4.7	-5.4	-5.7	-4.5
Wears glasses or contact lenses	3.2	3.7	8.7	-0.1	-1.4	2.0	2.6	3.0	1.0
Systolic blood pressure, automated reading	3.1	9.0	17.3	0.1	1.4	3.0	4.2	4.1	3.0
Medication: Paracetamol	3.1	4.8	8.0	1.2	0.2	2.7	2.8	2.8	2.0
Leg predicted mass (left)	3.0	15.6	28.0	-0.7	-2.3	-4.4	-5.1	-5.3	-3.8
Trunk fat-free mass	3.0	17.2	29.8	-0.1	-2.5	-4.4	-5.2	-5.5	-4.6
Trunk predicted mass	3.0	17.2	29.5	-0.1	-2.5	-4.4	-5.2	-5.4	-4.6
Commuting to job workplace: Public transport	3.0	3.6	6.1	1.1	-0.2	1.8	2.3	2.5	2.3
Lung FVC	2.9	14.6	20.4	4.4	1.3	3.0	4.5	4.1	4.4
Leg fat-free mass (left)	2.9	15.6	27.9	-0.7	-2.3	-4.4	-5.1	-5.3	-3.8
Hypothyroidism (self reported)	2.7	6.2	13.3	-1.9	-0.9	-1.5	-3.2	-3.6	-2.5
Ever had bowel cancer screening	2.7	3.2	4.8	-1.4	-1.6	-1.2	-2.2	-2.0	-2.1
Medication: Levothyroxine sodium	2.6	4.4	8.8	-2.7	-0.9	-0.4	-2.5	-3.0	-1.8
Impedance of arm (left)	2.6	12.3	22.3	0.6	0.9	3.9	4.5	4.7	3.9
Arm fat-free mass (right)	2.6	13.5	23.7	-0.6	-1.8	-4.4	-4.5	-4.9	-3.8
Medication: Bendroflumethiazide	2.5	3.7	7.2	1.7	-0.7	1.4	2.7	2.7	1.7
Basal metabolic rate	2.5	13.7	24.6	-0.2	-2.1	-4.2	-4.7	-5.0	-3.7
Arm predicted mass (left)	2.5	12.8	22.2	-0.3	-1.8	-4.2	-4.3	-4.7	-3.8
Medication: Blood pressure	2.4	4.3	8.4	1.0	1.5	0.9	2.8	2.9	2.3
Impedance of arm (right)	2.3	10.5	18.9	0.9	0.5	3.9	4.0	4.3	3.4
Arm predicted mass (right)	2.3	11.6	20.6	-0.5	-1.5	-4.1	-4.2	-4.5	-3.5
Arm fat-free mass (left)	2.3	11.5	20.1	0.0	-2.0	-3.9	-4.1	-4.5	-3.6
Supplements: Glucosamine	2.2	2.9	6.5	0.5	0.9	1.0	2.5	1.9	2.2
Medication: Blood pressure	2.2	4.1	6.2	2.1	-1.2	2.5	2.3	2.2	1.6
Irritable Bowel Disease (IBD)	2.1	5.0	9.0	-2.5	1.0	-0.9	-2.3	-3.0	-2.8
Diabetes (father)	2.1	2.6	4.8	1.4	-0.7	2.0	2.2	1.9	0.9
Hayfever, allergic rhinitis or eczema	2.1	4.6	6.2	1.9	1.9	2.1	2.5	2.3	2.2
Medication: Atenolol	2.1	2.7	4.6	1.3	0.0	2.1	1.9	1.9	1.6
Medication for pain relief, constipation, heartburn	2.1	3.6	7.0	-1.1	-0.6	-2.6	-2.1	-2.2	-1.9
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.3	4.6	0.0	2.1	1.8	1.7	1.2	1.3
Pain type(s) experienced in last month: Hip pain	2.1	2.6	5.2	-0.0	-2.3	-1.1	-1.7	-1.8	-1.7
Medication: Ramipril	2.0	2.5	5.0	0.8	-0.7	1.9	2.2	2.2	0.7
Medication: Paracetamol	2.0	3.2	6.0	1.1	-0.2	1.9	2.5	2.5	1.6
Medication: Allopurinol	2.0	2.6	5.4	-1.2	-1.0	-1.0	-2.1	-2.3	-1.5
Suffer from ‘nerves’	2.0	3.2	6.2	-2.5	-1.8	-1.4	-1.5	-1.5	-1.8
Loneliness, isolation	2.0	2.8	4.1	2.0	1.2	0.7	1.9	1.9	1.9
Qualifications: CSEs or equivalent	1.9	2.5	4.1	0.3	2.0	1.2	1.8	1.6	1.8
Financial situation satisfaction	1.9	2.3	4.1	-1.1	2.0	1.2	1.3	2.0	1.1
Ulcerative Colitis (UC)	1.8	3.3	6.3	-1.6	0.6	-0.7	-2.1	-2.4	-2.5
Alcohol usually taken with meals	1.8	3.0	6.1	1.2	-0.9	0.5	2.2	2.5	2.1
Qualifications: nursing, teaching	1.8	2.9	5.3	1.3	-1.1	1.1	2.1	2.3	1.9
Eye problems/disorders: Cataract	1.8	2.1	4.3	-0.0	0.7	1.6	2.1	2.0	1.2
Worry (Nagel 2018)	1.6	3.4	4.8	-2.1	-0.7	-1.8	-2.1	-2.2	-1.7
Hair/balding pattern: Pattern 2	1.6	2.0	5.2	1.1	1.0	0.7	1.6	1.3	2.3
Allergy	1.6	3.6	4.5	-1.7	-1.3	-2.0	-2.1	-2.0	-2.1
Hair/balding pattern: Pattern 3	1.6	2.4	4.8	-0.5	-0.9	-1.7	-1.8	-1.6	-2.2
Neuroticism	1.5	3.7	8.4	-2.9	0.3	-2.1	-2.2	-1.9	-1.0
Crohns Disease (2017)	1.4	3.0	5.9	-2.4	1.0	-0.5	-1.4	-2.2	-2.0
Ulcerative Colitis	1.4	2.1	4.2	-1.4	-0.1	0.0	-2.0	-2.1	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.1	5.1	2.0	0.9	1.4	2.0	2.3	1.7
Ever highly irritable/argumentative for 2 days	1.4	1.7	3.1	-0.7	-0.8	-0.6	-1.8	-1.7	-1.7
Comparative body size at age 10	1.4	4.0	6.5	-2.3	-1.9	-1.8	-2.6	-1.9	-1.4
Height	1.3	25.8	44.5	-1.0	-2.6	-4.7	-6.2	-6.7	-6.5
Noisy workplace	1.3	1.6	4.2	2.0	0.8	-0.7	-1.4	-1.3	-1.0
Asthma	1.3	2.5	4.3	1.7	1.0	1.2	1.9	2.1	1.3
Asthma (self-reported)	1.3	2.5	4.9	1.6	0.9	1.0	2.1	2.2	1.3
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	4.0	-0.2	0.5	2.0	1.5	1.7	0.2
Neuroticism (Nagel 2018)	1.2	2.8	5.2	-1.1	-0.2	-2.3	-2.0	-1.9	-1.7
Cardiovascular Disease	1.2	3.9	7.5	-0.2	-0.8	1.9	2.7	2.5	2.3
Diabetes (self-reported)	1.2	1.8	3.6	-1.0	-0.8	-0.0	-1.6	-1.7	-1.9
Qualifications: College or University degree	1.2	3.9	6.3	-1.6	-1.2	-1.7	-2.5	-2.4	-2.0
Mean time to correctly identify matches	1.2	2.3	5.6	-1.5	-0.8	-1.6	-1.2	-1.2	-2.4
Crohns Disease (2012)	1.1	1.8	3.8	-1.3	0.1	0.0	-1.3	-1.9	-2.0
Financial difficulties in last 2 years	1.1	1.4	4.8	0.7	2.2	-0.4	0.1	0.8	1.6
Neuroticism score	1.1	2.3	3.8	-1.4	-1.0	-1.5	-2.0	-1.8	-1.3
Lung cancer (father)	1.1	1.3	2.4	0.9	-1.6	0.6	-1.3	-1.1	-1.1
Had major operations	1.1	1.3	2.9	-1.0	1.7	-1.4	-0.9	-0.8	-0.6
Lupus	1.0	1.5	2.4	-0.8	-1.0	-1.5	-1.3	-1.4	-1.4
Number of treatments/medications taken	1.0	1.9	2.6	1.6	1.6	1.4	1.6	1.2	0.6
Weight	1.0	5.0	9.1	0.3	-1.3	-2.7	-2.8	-3.0	-2.0
Exposure to tobacco smoke outside home	1.0	1.4	2.5	-1.5	-0.3	-0.7	-1.3	-1.1	-1.6
Average weekly red wine intake	1.0	1.4	3.7	-0.8	-1.5	-1.9	-1.1	-0.7	-0.4
Mood swings	1.0	1.8	3.5	-1.9	-0.8	-1.4	-1.3	-1.1	-1.4
Mineral and other dietary supplements	1.0	1.3	3.4	-0.1	-0.0	-1.1	-1.9	-1.3	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.2	4.6	2.1	-0.2	1.7	1.6	1.4	1.1
Fractured/broken bones in last 5 years	1.0	1.3	3.7	1.2	0.2	-0.3	-1.1	-1.2	-1.9
Diastolic blood pressure, automated reading	1.0	3.0	5.3	-0.6	0.4	2.3	2.0	2.1	2.0
Unable to work because of sickness or disability	1.0	1.3	3.0	1.7	-1.7	0.9	0.7	0.8	-0.6
HbA1C	0.9	1.0	3.3	-0.3	1.8	-0.4	0.1	0.1	1.6
Neuroticism (2016)	0.9	1.3	3.6	-0.2	1.9	0.4	-1.3	-1.4	-0.5
Rheumatoid Arthritis	0.9	1.2	3.0	0.8	-0.5	-0.2	-1.3	-1.2	-1.7
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.8	0.3	1.2	1.2	1.3	1.0	-0.2
Taking other prescription medications	0.9	1.4	4.2	-0.6	1.1	0.9	-0.9	-1.1	-2.0
Happiness	0.9	1.1	2.4	-0.3	0.1	1.6	1.1	1.5	0.7
Pulse wave Arterial Stiffness index	0.9	1.0	2.7	0.2	-1.6	-0.3	-1.3	-1.2	-0.5
Gout (self-reported)	0.9	1.2	2.1	-0.9	-0.4	-1.0	-1.5	-1.4	-1.0
Chronic bronchitis/emphysema (mother)	0.9	1.1	2.3	0.4	-0.3	0.7	1.5	1.2	1.4
Hypertension (Self-reported)	0.9	2.5	5.0	0.6	0.7	1.5	2.2	2.2	1.4
Commuting to job workplace: Cycle	0.9	1.1	3.6	0.5	-0.4	1.9	0.7	0.9	1.3
Intelligence (Savage-Jansen 2018)	0.8	2.4	3.9	-1.2	-1.6	-1.6	-1.8	-2.0	-0.8
Smoking Status	0.8	1.8	4.8	-0.3	0.2	-1.3	-2.2	-1.8	-1.1
Supplements: Zinc	0.8	0.9	2.3	-1.5	-1.0	-0.5	-0.8	-0.8	-0.8
Current tobacco smoking	0.8	1.3	2.9	-0.6	-0.6	-1.1	-1.7	-1.6	-0.5
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	3.4	0.2	0.1	1.8	1.0	0.9	0.0
High blood pressure	0.8	2.3	4.7	0.3	0.8	1.4	2.2	2.2	1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	4.4	0.9	0.1	0.9	1.6	2.1	1.4
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	1.7	-0.9	0.2	0.8	1.3	1.0	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	2.0	-0.8	0.5	-1.3	-1.3	-1.4	-1.1
Pulse wave reflection index	0.8	0.9	2.1	-0.5	-1.2	-0.5	-1.4	-1.1	-0.5
Headache pain in last month	0.8	1.4	2.6	0.9	-1.4	-0.1	-1.0	-1.4	-1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.3	-0.2	-0.5	-0.6	-1.2	-1.4	-1.5
Pulse wave peak to peak time	0.8	0.9	2.3	0.1	1.5	0.2	1.3	1.2	0.4
Medication: Omeprazole	0.8	1.0	3.2	0.1	-0.1	1.8	1.2	1.1	-0.1
Pulse rate, automated reading	0.8	2.6	4.3	2.0	-0.5	0.5	2.1	1.9	1.8
Alcohol intake frequency.	0.8	1.9	7.7	0.5	-0.4	2.8	1.5	0.8	0.7
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.8	-0.6	-1.0	-0.8	-1.0	-1.3	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	2.9	0.7	0.5	-1.6	-1.5	-1.7	-1.3
Long-standing illness, disability or infirmity	0.8	1.3	2.9	0.6	-1.5	1.7	-0.1	0.1	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	4.1	2.0	0.0	-0.1	0.5	0.2	1.2
Illnesses of father: None of the above (group 1)	0.8	1.0	2.4	0.0	-0.1	-1.3	-1.5	-1.3	-0.3
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.8	0.1	-0.7	-1.0	-1.2	-1.4	-0.7
Medication: Lisinopril	0.8	1.1	1.9	1.4	0.2	0.4	1.2	1.1	1.3
Supplements: Calcium	0.8	0.9	3.3	-1.8	0.3	0.4	-1.0	-0.8	-0.1
Alcohol drinker status: Previous	0.8	0.9	1.6	-0.1	-1.3	0.7	-1.1	-1.0	-0.9
Major Depression (MDD)	0.7	0.8	2.1	-1.0	0.1	0.0	-1.2	-1.4	-0.5
Reaction Time	0.7	1.3	3.0	-1.5	0.0	-1.4	-0.5	-0.7	-1.7
Breast Cancer	0.7	1.8	7.8	0.2	2.8	0.0	-1.3	-0.7	-0.8
Heel T-Score	0.7	5.4	10.8	1.7	1.6	-0.3	2.5	3.1	3.3
Severe depression (siblings)	0.7	0.8	2.2	-0.3	0.4	-0.4	-1.2	-1.5	-0.7
Fed-up feelings	0.7	1.3	1.9	1.1	0.5	1.0	1.4	1.2	1.3
Serious illness, injury or assault to yourself	0.7	0.8	3.4	0.3	-0.5	1.9	0.5	0.5	-0.9
Number of incorrect matches in round	0.7	1.1	3.0	1.7	0.3	-1.4	-0.7	-1.1	-0.3
Forced vital capacity (FVC)	0.7	2.6	8.4	2.9	-0.2	1.3	1.6	1.2	1.2
Falls in the last year	0.7	1.0	2.8	-0.2	1.0	-0.7	-1.7	-1.2	-0.4
Pulse rate	0.7	1.2	2.1	1.2	-1.5	0.8	1.0	0.8	1.1
Standing height	0.7	6.8	10.1	1.3	-2.0	-2.5	-2.9	-3.1	-3.2
Breastfed as a baby	0.7	0.9	2.8	1.1	1.7	-0.1	0.6	0.8	0.6
Peak expiratory flow (PEF)	0.7	1.7	3.1	0.8	-1.8	-1.2	-1.3	-1.3	-1.1
Loud music exposure frequency	0.7	0.8	1.9	-1.1	1.4	0.7	0.3	0.4	0.8
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	2.5	0.5	0.3	1.0	1.3	1.1	1.6
Leg fat percentage (right)	0.7	2.5	4.6	0.7	0.8	1.1	2.1	2.1	1.9
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.7	-0.8	-1.3	-1.1	-0.8	-0.6	-0.2
Emphysema/chronic bronchitis	0.7	0.8	2.1	-0.0	-1.4	0.2	-1.2	-0.9	-0.6
Neck or shoulder pain in last month	0.7	1.0	2.8	0.2	0.2	1.7	1.3	1.1	0.2
Comparative height size at age 10	0.7	3.7	8.8	-0.0	-1.0	-0.9	-2.1	-2.6	-3.0
Smoking status: Current	0.7	1.1	2.3	-0.4	-0.8	-1.1	-1.5	-1.4	-0.2
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.2	0.4	0.1	1.2	1.5	0.9	0.8
Alcohol drinker status: Never	0.7	0.8	1.6	0.2	-1.3	1.0	-0.4	-0.8	-1.2
Age started oral contraceptive pill	0.7	0.9	1.8	1.1	-0.2	-0.2	1.3	1.0	1.1
Vascular/heart problems diagnosed by doctor	0.7	1.9	3.9	-0.3	-0.8	-1.2	-2.0	-1.9	-1.3
Cholesterol lowering medication	0.7	1.0	2.8	-0.0	0.1	0.9	1.1	1.1	1.7
Alzheimer’s Disease (in father)	0.6	0.6	2.4	-1.0	-1.6	0.0	-0.0	0.1	-0.5
Blood White Count	0.6	4.2	12.6	0.9	1.5	0.0	2.2	2.2	3.5
Vitamin and mineral supplements	0.6	0.8	2.1	0.5	-0.2	1.4	0.7	0.9	0.9
Maternal smoking around birth	0.6	0.9	2.0	-1.0	-0.2	-1.1	-1.2	-1.4	-0.3
Age when periods started (menarche)	0.6	1.4	3.0	1.6	1.7	0.3	0.8	1.2	0.5
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.3	0.6	-1.2	-1.5	0.2	-0.0	-0.2
Multivitamins +/- minerals	0.6	0.8	2.4	-0.2	0.3	-1.6	-0.7	-1.0	-0.7
Stomach or abdominal pain in last month	0.6	0.8	1.5	0.9	-0.6	-0.6	-1.2	-1.2	-0.6
Had other major operations	0.6	0.7	1.2	0.5	0.7	1.1	1.1	0.9	0.4
Heart attack	0.6	0.7	3.7	0.2	1.9	-0.8	-0.1	0.0	-0.0
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	5.7	2.4	-0.8	1.3	1.5	1.0	0.9
Length of working week for main job	0.6	0.6	2.4	-1.5	-0.3	0.4	-0.5	-0.6	-0.7
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	1.8	-0.8	-1.3	-0.1	-1.3	-1.1	-0.7
High blood pressure (siblings)	0.6	0.8	3.4	0.0	0.0	1.8	0.8	0.9	0.1
Number of children fathered	0.6	0.6	2.2	-0.8	0.5	0.4	-0.4	-0.5	-1.5
Eye problems/disorders: None of the above	0.6	0.7	1.6	0.1	-1.3	0.2	-1.0	-1.0	-0.6
Chest pain or discomfort	0.6	0.9	2.8	-0.1	-0.2	0.0	-1.7	-1.1	-1.2
Leg pain on walking	0.6	0.7	1.5	-1.2	-1.0	1.0	0.2	0.1	-0.8
Illnesses of siblings: Diabetes	0.6	0.7	1.4	0.1	-1.2	-1.0	-0.7	-0.6	-0.9
Breast cancer (self-reported)	0.6	0.7	2.2	1.5	-1.1	-0.8	-0.1	-0.4	0.1
Osteoporosis (self-reported)	0.6	0.7	2.9	-1.7	0.7	0.1	-0.8	-0.3	-0.1
Medication: Gliclazide	0.6	0.7	1.3	-1.1	0.1	0.4	-1.1	-0.8	-0.8
Average weekly beer plus cider intake	0.6	0.8	3.8	0.8	0.6	2.0	-0.1	-0.1	0.4
Ovarian Cancer	0.5	0.7	1.6	0.6	-1.0	-1.3	-0.6	-0.5	-0.9
Age at First Birth	0.5	0.7	1.5	0.4	-0.8	-0.6	1.0	1.2	0.8
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.8	-1.3	-0.4	0.0	-0.6	-0.5	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.6	-1.1	-0.4	-0.2	-1.1	-0.8	-1.3
Had menopause	0.5	0.6	1.1	0.8	0.6	1.1	0.5	1.0	-0.1
Hip circumference	0.5	2.1	3.8	0.2	-0.8	-1.6	-1.8	-1.9	-1.4
Father’s age at death	0.5	0.7	2.0	-1.4	-0.0	0.7	0.9	0.9	-0.4
Worrier / anxious feelings	0.5	1.0	2.3	0.0	-1.5	-1.4	-0.8	-0.9	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.7	1.0	-0.8	-1.3	-0.8	-0.4	0.4
Exposure to tobacco smoke at home	0.5	0.5	2.3	-0.8	-0.4	-1.5	-0.0	0.2	0.1
Body fat percentage	0.5	2.0	4.5	0.4	0.7	0.7	1.8	1.8	2.1
Age at first live birth	0.5	0.9	2.0	0.6	-0.3	0.6	1.4	1.4	0.9
Health satisfaction	0.5	0.7	1.6	-1.2	0.8	1.3	-0.1	0.2	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.6	1.6	-0.6	0.8	0.1	-0.2	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.7	-0.2	-1.3	1.2	0.1	0.4	-0.5
Medication for cholesterol	0.5	0.8	1.7	-0.6	0.4	-1.3	-0.8	-0.9	-1.0
Average weekly champagne plus white wine intake	0.5	0.7	0.9	-0.8	-0.7	-1.0	-1.0	-0.8	-0.8
Mother’s age at death	0.5	0.7	2.0	1.0	1.4	0.2	-0.1	0.6	0.9
Illnesses of father: High blood pressure	0.5	0.6	2.1	0.2	0.6	1.5	0.8	0.8	0.2
Leg fat percentage (left)	0.5	1.9	3.4	0.6	0.6	0.9	1.9	1.9	1.8
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.1	0.6	1.0	1.0	0.5	0.8	-0.2
Heart attack/myocardial infarction (self-reported)	0.5	0.6	2.3	0.6	1.5	-0.9	-0.1	0.0	-0.2
Heart disease (siblings)	0.5	0.6	2.4	-0.1	-0.9	1.6	0.3	0.5	-0.0
Verbal and Numeric Reasoning (VNR)	0.4	0.9	3.6	-0.6	-1.9	-1.0	-0.5	-0.4	-0.1
Prostate Cancer	0.4	0.5	1.5	-1.1	1.2	-0.2	0.2	0.3	0.5
Blood Red Count	0.4	3.4	6.9	-1.5	-1.2	-1.8	-2.3	-2.6	-1.3
Respiratory disease	0.4	1.0	2.6	0.3	0.1	0.6	1.5	1.6	0.7
Chronotype (morning person)	0.4	0.8	3.0	-1.7	-0.7	0.8	0.1	-0.2	0.9
Ever had hysterectomy (womb removed)	0.4	0.4	0.9	-0.2	-0.9	-0.1	-0.8	-1.0	-0.5
Medication for hormone replacement therapy	0.4	0.5	1.5	0.4	0.9	0.2	-1.2	-0.5	-0.4
Pack years adult smoking proportion	0.4	0.6	1.3	0.6	0.8	-0.3	-1.2	-1.0	-0.5
Average weekly fortified wine intake	0.4	0.5	2.3	-0.5	-0.6	-1.5	-0.1	-0.4	-0.1
Relative age voice broke	0.4	0.6	3.0	1.7	-0.5	-0.3	0.0	-0.3	-0.6
Waist circumference	0.4	1.5	2.5	-0.5	-0.9	-1.3	-1.6	-1.5	-1.1
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.3	0.6	1.1	0.8	0.1	0.4	0.7
Pain all over the body in last month	0.4	0.4	0.8	0.3	0.9	0.8	0.3	0.5	0.8
Alcohol intake versus 10 years previously	0.4	0.5	1.7	1.3	-0.0	1.1	-0.2	-0.3	-0.5
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.0	-1.2	-0.3	0.9	0.6	0.8	1.4
Mouth/teeth dental problems: Dentures	0.4	0.7	1.6	1.2	-1.3	-0.2	0.5	0.9	0.0
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.9	0.5	0.7	0.3	0.8	1.0	0.6
Medication: Cholesterol lowering	0.4	0.7	3.6	0.1	1.9	-0.5	0.3	0.1	-0.3
Medication: Lansoprazole	0.4	0.4	2.3	0.2	1.5	0.5	-0.2	-0.2	0.2
Blood clot in the leg (DVT)	0.4	0.5	1.4	0.4	-1.1	-1.2	-0.4	-0.2	0.2
Glaucoma (self-reported)	0.4	0.4	0.9	1.0	0.2	0.7	0.6	0.8	0.4
Forced vital capacity (FVC), Best measure	0.4	1.3	5.1	2.3	-0.2	1.1	0.6	0.3	1.0
Shortness of breath walking on level ground	0.4	0.4	1.2	-1.0	0.3	1.1	0.1	0.3	-0.4
Angina (self-reported)	0.4	0.5	1.3	-0.1	1.1	0.8	0.7	0.7	0.2
Number of full sisters	0.4	0.5	0.9	0.6	-0.3	0.9	-0.5	-1.0	-0.8
Medication: Aspirin	0.4	0.5	0.9	0.7	0.9	0.9	0.4	0.6	0.5
Eye problems/disorders: Glaucoma	0.4	0.4	0.6	-0.1	0.7	0.6	0.8	0.8	0.7
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.4	0.4	-1.2	-1.2	-0.2	-0.1	0.2
Alzheimer’s Disease (in mother)	0.3	0.3	0.7	0.7	-0.4	-0.1	0.7	0.9	0.1
Body Mass Index (BMI) (2010)	0.3	0.4	1.0	1.0	0.2	0.2	-0.6	-0.8	-0.5
Blood Eosinophil Count	0.3	2.6	9.8	-0.5	2.3	-0.1	0.1	0.3	3.1
BMI	0.3	1.9	3.8	-0.9	-0.2	-1.8	-1.8	-2.0	-0.7
Tanning	0.3	3.1	7.9	0.7	0.6	1.5	2.2	1.8	2.8
Sensitivity / hurt feelings	0.3	0.4	1.1	-1.1	-0.4	-0.3	-0.6	-0.6	-0.7
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.9	0.3	-0.3	-0.0	-0.4	-0.6	-1.4
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.8	-0.2	0.9	0.7	-0.7	-0.3	-0.4
Angina	0.3	0.4	1.2	-0.2	1.1	0.3	0.6	0.7	0.0
Trunk fat percentage	0.3	1.3	3.3	0.5	0.8	0.3	1.4	1.3	1.8
Hand grip strength (right)	0.3	0.8	1.3	-0.7	-0.6	-0.9	-0.9	-1.1	-1.0
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.0	1.0	-0.2	1.0	0.0	-0.1	-0.5
Chronic bronchitis/emphysema (father)	0.3	0.4	0.9	0.2	-0.4	-1.0	-0.8	-0.6	-0.5
Body mass index (BMI)	0.3	1.5	3.0	-0.2	-0.5	-1.7	-1.5	-1.7	-0.6
Qualifications: None of the above	0.3	0.6	2.6	0.0	1.6	1.0	0.2	0.3	-0.3
Mouth/teeth dental problems	0.3	0.5	1.9	0.2	0.8	1.4	0.3	0.0	0.3
Medication: Simvastatin	0.3	0.4	1.4	0.7	1.2	0.3	0.5	0.1	0.5
Fluid intelligence score	0.3	0.7	2.2	-0.9	-1.5	-1.0	-0.4	-0.4	0.1
Illnesses of siblings	0.3	0.4	1.2	-0.0	0.5	-0.8	-0.1	-0.1	1.1
Number of live births	0.3	0.5	1.3	-1.1	-1.1	-0.5	0.4	0.2	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	2.3	1.5	-0.3	1.1	0.8	0.3	0.9
Arm fat mass (right)	0.3	1.1	2.8	0.2	-0.8	-1.7	-1.2	-1.3	-0.4
Hair/balding pattern: Pattern 4	0.3	0.8	1.5	1.1	-0.1	0.6	1.2	1.2	-0.2
Medication: Ventolin 100micrograms inhaler	0.3	0.3	0.9	1.0	0.5	0.5	0.3	0.3	-0.7
Birth weight	0.3	0.6	1.5	0.7	1.2	-0.3	-0.5	-0.6	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.3	0.2	-1.0	0.2	0.1	-0.0	-1.1
Smoking status: Previous	0.3	0.4	0.8	0.7	0.6	0.9	0.2	0.8	-0.2
Friendships satisfaction	0.3	0.4	0.6	-0.8	0.4	0.8	0.4	0.6	0.5
Commuting to job workplace: Walk	0.3	0.3	0.7	0.5	-0.4	0.1	0.5	0.8	0.6
Osteoarthritis (self-reported)	0.3	0.4	1.2	-0.7	-0.8	1.1	0.3	0.1	-0.4
Hearing aid user	0.3	0.3	0.6	-0.2	0.2	-0.3	-0.6	-0.8	-0.8
Ever depressed for a whole week	0.3	0.3	0.7	0.6	0.2	0.9	0.4	0.6	0.7
Basal cell carcinoma (self-reported)	0.3	0.4	0.9	0.1	-0.9	-1.0	0.5	0.6	0.0
Pack years of smoking	0.3	0.5	1.2	0.3	0.7	-0.3	-1.1	-0.9	-0.5
Depression (Nagel 2018)	0.2	0.3	0.8	-0.0	-0.3	0.6	0.4	0.6	0.9
Alzheimer’s Disease (including proxy)	0.2	0.3	1.2	-0.5	-1.1	-0.1	0.1	0.3	-0.5
Bipolar Disorder (2011)	0.2	0.2	0.7	0.0	0.0	0.0	0.0	-0.8	-0.6
Triglycerides	0.2	0.3	0.6	0.2	-0.8	0.8	0.1	0.1	0.7
Waist Hip Ratio (WHR)	0.2	0.8	1.5	-1.2	-1.0	0.8	0.7	1.0	0.2
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.4	-0.2	-0.9	1.2	0.1	0.0	-0.4
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.7	-0.8	0.4	0.3	0.2	0.5	0.7
Medication: Co-codamol	0.2	0.3	1.0	0.3	0.3	1.0	0.3	0.6	0.1
Townsend deprivation index at recruitment	0.2	0.2	0.8	-0.1	0.1	0.9	0.4	0.5	0.3
Sitting height	0.2	1.3	4.2	2.1	-0.7	0.9	1.1	0.8	0.7
Time employed in main current job	0.2	0.2	1.0	-1.0	0.2	0.1	-0.1	-0.2	-0.3
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.6	-0.6	-0.8	-0.4	-0.4	-0.4	0.5
Wheeze or whistling in the chest in last year	0.2	0.3	1.0	0.4	-0.2	-0.5	-0.7	-0.3	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.8	0.6	-0.9	-0.6	-0.1	-0.1	0.2
Migraine (self-reported)	0.2	0.3	0.9	-0.3	0.5	-0.1	-0.1	-0.6	-0.9
Family relationship satisfaction	0.2	0.3	1.0	-0.2	-0.6	1.0	0.0	0.2	-0.3
Diabetes diagnosed by doctor	0.2	0.4	0.9	-0.7	-0.2	1.0	-0.2	-0.2	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.8	0.9	-0.7	-0.4	0.1	0.2	-0.3
Medication: Aspirin	0.2	0.3	1.0	0.4	1.0	0.7	-0.0	0.2	0.5
Arm fat mass (left)	0.2	0.8	2.1	0.1	-0.8	-1.5	-0.9	-1.1	-0.3
Ever taken oral contraceptive pill	0.2	0.2	0.9	-0.3	0.0	-0.9	-0.3	-0.4	0.1
High cholesterol (Self-reported)	0.2	0.3	1.0	-0.3	0.2	-1.0	0.5	0.1	0.7
Medication: Atorvastatin	0.2	0.2	0.5	-0.2	0.1	-0.1	0.6	0.7	0.6
Ever smoked	0.2	0.3	1.1	0.2	-1.0	-0.1	-0.7	-0.2	-0.6
Number of operations (self-reported)	0.2	0.3	0.7	-0.7	0.6	-0.2	-0.0	-0.1	-0.8
Depressed Affect (Nagel 2018)	0.1	0.2	0.4	-0.1	0.5	-0.6	0.4	0.4	0.5
Schizophrenia vs Biploar Disorder	0.1	0.2	0.3	0.6	-0.0	0.0	-0.5	-0.6	-0.4
Coronary Artery Disease (CAD)	0.1	0.1	0.3	-0.1	0.0	0.0	-0.3	-0.4	0.5
Fasting Glucose	0.1	0.2	0.3	-0.4	0.6	0.3	0.3	0.4	0.4
HDL Cholesterol	0.1	0.1	0.2	0.1	-0.3	-0.0	-0.3	-0.4	-0.5
LDL Cholesterol	0.1	0.2	0.4	0.6	-0.6	0.4	0.3	0.6	0.1
Blood Platelet Count	0.1	1.2	4.8	2.2	0.1	0.9	0.4	0.3	1.2
Lung FEV1/FVC ratio	0.1	0.6	1.0	-1.0	-0.9	-0.9	-0.6	-0.8	-0.4
Hair Pigment	0.1	1.8	7.4	-2.7	0.7	0.6	-0.8	-0.9	-1.1
Hand grip strength (left)	0.1	0.2	0.7	0.8	-0.5	0.2	-0.2	-0.5	-0.2
Medication: Metformin	0.1	0.1	0.3	-0.3	-0.1	0.1	-0.4	-0.6	-0.4
Diabetes (mother)	0.1	0.2	0.3	0.2	0.5	0.5	0.4	0.2	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.4	0.2	-0.6	0.6	-0.3	-0.2	-0.3
Past tobacco smoking	0.1	0.1	0.3	-0.5	0.2	-0.3	0.2	-0.4	0.0
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.3	0.1	0.3	-0.2	0.5	0.3	0.5
Arm fat percentage (right)	0.1	0.3	1.2	0.2	-0.0	-0.0	0.5	0.5	1.1
Depression (self-reported)	0.1	0.1	0.3	0.1	0.3	0.5	-0.0	0.0	-0.3
Prospective memory result	0.1	0.2	0.5	0.7	-0.1	0.6	-0.2	-0.1	-0.3
Birth weight of first child	0.1	0.3	0.8	-0.6	0.9	0.4	0.5	0.2	0.1
Number of full brothers	0.1	0.2	0.7	0.2	-0.8	-0.1	-0.3	-0.5	-0.3
Medication: Ibuprofen	0.1	0.1	0.5	-0.2	0.7	0.4	0.2	0.3	-0.3
Whole body fat mass	0.1	0.2	0.8	0.1	-0.1	-0.9	-0.3	-0.5	0.2
Age at last live birth	0.1	0.1	0.2	-0.3	-0.4	-0.3	0.2	0.2	-0.3
Supplements: Vitamin C	0.1	0.1	0.4	0.3	0.4	-0.6	-0.1	-0.0	0.4
Knee pain experienced in last month	0.1	0.2	1.2	-0.3	-1.1	-0.2	0.1	0.1	-0.2
Illnesses of father: Heart disease	0.1	0.1	0.2	-0.5	0.4	0.1	-0.0	-0.3	-0.1
Arm fat percentage (left)	0.1	0.5	2.0	0.1	0.2	-0.0	0.7	0.7	1.4
Number of self-reported non-cancer illnesses	0.1	0.2	0.6	-0.4	0.8	0.3	0.1	-0.2	-0.6
Miserableness	0.1	0.2	0.7	-0.8	0.2	0.2	-0.6	-0.4	-0.5
Leg fat mass (left)	0.1	0.4	1.3	-0.0	-0.1	-1.1	-0.6	-0.7	-0.2
Primary Biliary Cirrhosis	0.0	0.1	0.2	-0.1	-0.1	0.4	0.0	0.3	-0.3
Relative age of first facial hair	0.0	0.0	0.1	-0.1	0.3	0.2	0.3	0.2	0.1
Trunk fat mass	0.0	0.2	0.8	0.4	-0.0	-0.9	-0.2	-0.4	0.3
Nervous feelings	0.0	0.0	0.1	-0.2	0.2	-0.1	-0.1	-0.3	0.0
Leg fat mass (right)	0.0	0.2	0.8	0.0	0.0	-0.9	-0.3	-0.3	0.1
Overall health rating	0.0	0.1	0.2	-0.4	-0.2	0.5	0.0	0.1	-0.3
Pain experienced in last month	0.0	0.0	0.1	0.1	-0.1	0.4	0.0	0.2	0.2

Hub : Genes

PPAPDC1B

Models

Trait associations