Hub : Genes

PPAPDC1B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0470	0.0270	8.0e-03	0.011	0.013	0.017	0.017	0.009	1.6e-02	9.6e-03	2.9e-03	3.5e-03	2.3e-02
2	GTEx	Artery Tibial	0.0899	0.0429	8.0e-03	-0.003	NA	-0.001	NA	-0.003	8.4e-01	NA	3.9e-01	NA	7.7e-01
3	GTEx	Testis	0.1050	0.0460	5.0e-03	0.024	NA	-0.006	NA	0.067	2.9e-02	NA	8.9e-01	NA	6.6e-04
4	ROSMAP	Brain Pre-frontal Cortex	0.0561	0.0165	1.4e-08	0.082	0.083	0.086	0.085	0.084	1.0e-10	8.4e-11	4.0e-11	4.8e-11	6.0e-11
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0171	0.0156	9.9e-03	0.005	0.008	0.002	NA	0.001	8.3e-02	4.2e-02	1.6e-01	NA	2.2e-01
6	TCGA	Pancreatic Adenocarcinoma	0.1380	0.1550	9.7e-04	0.061	0.067	0.081	NA	0.077	1.5e-03	9.2e-04	2.7e-04	NA	4.0e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	8.1	12.8	26.0	-2.6	0.1	0.0	-4.5	-5.1	-4.9
Bipolar Disorder or Schizophrenia	7.9	19.2	43.4	-2.2	-0.0	0.0	-5.7	-6.6	-5.8
Depressed Affect (Nagel 2018)	0.1	0.2	0.4	-0.1	0.5	-0.6	0.4	0.4	0.5
Depression (Nagel 2018)	0.2	0.3	0.8	-0.0	-0.3	0.6	0.4	0.6	0.9
Intelligence (Savage-Jansen 2018)	0.8	2.4	3.9	-1.2	-1.6	-1.6	-1.8	-2.0	-0.8
Neuroticism (Nagel 2018)	1.2	2.8	5.2	-1.1	-0.2	-2.3	-2.0	-1.9	-1.7
Schizophrenia (2018)	3.7	7.7	18.8	-0.7	-0.1	0.0	-3.7	-4.3	-3.6
Schizophrenia vs Biploar Disorder	0.1	0.2	0.3	0.6	-0.0	0.0	-0.5	-0.6	-0.4
Worry (Nagel 2018)	1.6	3.4	4.8	-2.1	-0.7	-1.8	-2.1	-2.2	-1.7
Alzheimer’s Disease (in mother)	0.3	0.3	0.7	0.7	-0.4	-0.1	0.7	0.9	0.1
Alzheimer’s Disease (in father)	0.6	0.6	2.4	-1.0	-1.6	0.0	-0.0	0.1	-0.5
Alzheimer’s Disease (including proxy)	0.2	0.3	1.2	-0.5	-1.1	-0.1	0.1	0.3	-0.5
Crohns Disease (2017)	1.4	3.0	5.9	-2.4	1.0	-0.5	-1.4	-2.2	-2.0
Irritable Bowel Disease (IBD)	2.1	5.0	9.0	-2.5	1.0	-0.9	-2.3	-3.0	-2.8
Ulcerative Colitis (UC)	1.8	3.3	6.3	-1.6	0.6	-0.7	-2.1	-2.4	-2.5
Major Depression (MDD)	0.7	0.8	2.1	-1.0	0.1	0.0	-1.2	-1.4	-0.5
Reaction Time	0.7	1.3	3.0	-1.5	0.0	-1.4	-0.5	-0.7	-1.7
Verbal and Numeric Reasoning (VNR)	0.4	0.9	3.6	-0.6	-1.9	-1.0	-0.5	-0.4	-0.1
Breast Cancer	0.7	1.8	7.8	0.2	2.8	0.0	-1.3	-0.7	-0.8
Ovarian Cancer	0.5	0.7	1.6	0.6	-1.0	-1.3	-0.6	-0.5	-0.9
Prostate Cancer	0.4	0.5	1.5	-1.1	1.2	-0.2	0.2	0.3	0.5
Age at First Birth	0.5	0.7	1.5	0.4	-0.8	-0.6	1.0	1.2	0.8
Bipolar Disorder (2011)	0.2	0.2	0.7	0.0	0.0	0.0	0.0	-0.8	-0.6
Body Mass Index (BMI) (2010)	0.3	0.4	1.0	1.0	0.2	0.2	-0.6	-0.8	-0.5
Coronary Artery Disease (CAD)	0.1	0.1	0.3	-0.1	0.0	0.0	-0.3	-0.4	0.5
Crohns Disease (2012)	1.1	1.8	3.8	-1.3	0.1	0.0	-1.3	-1.9	-2.0
Mean Putamen Volume	4.2	4.8	8.9	0.2	-1.2	-3.0	-3.0	-2.8	-1.4
Fasting Glucose	0.1	0.2	0.3	-0.4	0.6	0.3	0.3	0.4	0.4
HbA1C	0.9	1.0	3.3	-0.3	1.8	-0.4	0.1	0.1	1.6
HDL Cholesterol	0.1	0.1	0.2	0.1	-0.3	-0.0	-0.3	-0.4	-0.5
LDL Cholesterol	0.1	0.2	0.4	0.6	-0.6	0.4	0.3	0.6	0.1
Lupus	1.0	1.5	2.4	-0.8	-1.0	-1.5	-1.3	-1.4	-1.4
Neuroticism (2016)	0.9	1.3	3.6	-0.2	1.9	0.4	-1.3	-1.4	-0.5
Primary Biliary Cirrhosis	0.0	0.1	0.2	-0.1	-0.1	0.4	0.0	0.3	-0.3
Rheumatoid Arthritis	0.9	1.2	3.0	0.8	-0.5	-0.2	-1.3	-1.2	-1.7
Schizophrenia (2014)	4.0	8.8	21.4	-1.3	0.3	0.0	-4.0	-4.6	-3.7
Triglycerides	0.2	0.3	0.6	0.2	-0.8	0.8	0.1	0.1	0.7
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.8	-1.3	-0.4	0.0	-0.6	-0.5	-1.0
Ulcerative Colitis	1.4	2.1	4.2	-1.4	-0.1	0.0	-2.0	-2.1	-1.5
Blood Eosinophil Count	0.3	2.6	9.8	-0.5	2.3	-0.1	0.1	0.3	3.1
Blood Platelet Count	0.1	1.2	4.8	2.2	0.1	0.9	0.4	0.3	1.2
Blood Red Count	0.4	3.4	6.9	-1.5	-1.2	-1.8	-2.3	-2.6	-1.3
Blood White Count	0.6	4.2	12.6	0.9	1.5	0.0	2.2	2.2	3.5
Heel T-Score	0.7	5.4	10.8	1.7	1.6	-0.3	2.5	3.1	3.3
BMI	0.3	1.9	3.8	-0.9	-0.2	-1.8	-1.8	-2.0	-0.7
Height	1.3	25.8	44.5	-1.0	-2.6	-4.7	-6.2	-6.7	-6.5
Waist Hip Ratio (WHR)	0.2	0.8	1.5	-1.2	-1.0	0.8	0.7	1.0	0.2
Systolic Blood Pressure	6.1	30.5	56.1	2.0	2.2	5.1	7.3	7.5	6.2
Smoking Status	0.8	1.8	4.8	-0.3	0.2	-1.3	-2.2	-1.8	-1.1
Allergy or Eczema	3.4	9.0	13.1	2.1	3.0	2.5	3.6	3.6	3.0
Cardiovascular Disease	1.2	3.9	7.5	-0.2	-0.8	1.9	2.7	2.5	2.3
Hypothyroidism (self reported)	2.7	6.2	13.3	-1.9	-0.9	-1.5	-3.2	-3.6	-2.5
Respiratory disease	0.4	1.0	2.6	0.3	0.1	0.6	1.5	1.6	0.7
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.4	-0.2	-0.9	1.2	0.1	0.0	-0.4
Lung FEV1/FVC ratio	0.1	0.6	1.0	-1.0	-0.9	-0.9	-0.6	-0.8	-0.4
Lung FVC	2.9	14.6	20.4	4.4	1.3	3.0	4.5	4.1	4.4
Neuroticism	1.5	3.7	8.4	-2.9	0.3	-2.1	-2.2	-1.9	-1.0
Chronotype (morning person)	0.4	0.8	3.0	-1.7	-0.7	0.8	0.1	-0.2	0.9
Hair Pigment	0.1	1.8	7.4	-2.7	0.7	0.6	-0.8	-0.9	-1.1
Tanning	0.3	3.1	7.9	0.7	0.6	1.5	2.2	1.8	2.8
Hand grip strength (left)	0.1	0.2	0.7	0.8	-0.5	0.2	-0.2	-0.5	-0.2
Number of treatments/medications taken	1.0	1.9	2.6	1.6	1.6	1.4	1.6	1.2	0.6
Average weekly spirits intake	7.3	9.1	15.2	-1.1	-1.7	-3.2	-3.9	-3.8	-3.3
Sensitivity / hurt feelings	0.3	0.4	1.1	-1.1	-0.4	-0.3	-0.6	-0.6	-0.7
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.7	-0.8	0.4	0.3	0.2	0.5	0.7
Hearing difficulty/problems: Yes	6.5	9.9	15.5	-0.9	-2.6	-2.9	-3.6	-3.9	-3.9
Relative age of first facial hair	0.0	0.0	0.1	-0.1	0.3	0.2	0.3	0.2	0.1
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.9	0.3	-0.3	-0.0	-0.4	-0.6	-1.4
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.8	-0.2	0.9	0.7	-0.7	-0.3	-0.4
Ever had hysterectomy (womb removed)	0.4	0.4	0.9	-0.2	-0.9	-0.1	-0.8	-1.0	-0.5
Systolic blood pressure, automated reading	3.1	9.0	17.3	0.1	1.4	3.0	4.2	4.1	3.0
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.8	0.3	1.2	1.2	1.3	1.0	-0.2
Angina	0.3	0.4	1.2	-0.2	1.1	0.3	0.6	0.7	0.0
Medication for hormone replacement therapy	0.4	0.5	1.5	0.4	0.9	0.2	-1.2	-0.5	-0.4
Vitamin and mineral supplements	0.6	0.8	2.1	0.5	-0.2	1.4	0.7	0.9	0.9
Supplements: Zinc	0.8	0.9	2.3	-1.5	-1.0	-0.5	-0.8	-0.8	-0.8
Medication: Co-codamol	0.2	0.3	1.0	0.3	0.3	1.0	0.3	0.6	0.1
Medication: Metformin	0.1	0.1	0.3	-0.3	-0.1	0.1	-0.4	-0.6	-0.4
Diabetes (father)	2.1	2.6	4.8	1.4	-0.7	2.0	2.2	1.9	0.9
Diabetes (mother)	0.1	0.2	0.3	0.2	0.5	0.5	0.4	0.2	-0.5
Severe depression (siblings)	0.7	0.8	2.2	-0.3	0.4	-0.4	-1.2	-1.5	-0.7
Pack years adult smoking proportion	0.4	0.6	1.3	0.6	0.8	-0.3	-1.2	-1.0	-0.5
Impedance of leg (right)	4.6	22.5	39.1	2.1	2.9	5.1	6.2	6.3	4.3
Leg fat-free mass (left)	2.9	15.6	27.9	-0.7	-2.3	-4.4	-5.1	-5.3	-3.8
Trunk fat percentage	0.3	1.3	3.3	0.5	0.8	0.3	1.4	1.3	1.8
Hand grip strength (right)	0.3	0.8	1.3	-0.7	-0.6	-0.9	-0.9	-1.1	-1.0
Townsend deprivation index at recruitment	0.2	0.2	0.8	-0.1	0.1	0.9	0.4	0.5	0.3
Current tobacco smoking	0.8	1.3	2.9	-0.6	-0.6	-1.1	-1.7	-1.6	-0.5
Average weekly fortified wine intake	0.4	0.5	2.3	-0.5	-0.6	-1.5	-0.1	-0.4	-0.1
Maternal smoking around birth	0.6	0.9	2.0	-1.0	-0.2	-1.1	-1.2	-1.4	-0.3
Fed-up feelings	0.7	1.3	1.9	1.1	0.5	1.0	1.4	1.2	1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.4	0.2	-0.6	0.6	-0.3	-0.2	-0.3
Relative age voice broke	0.4	0.6	3.0	1.7	-0.5	-0.3	0.0	-0.3	-0.6
Taking other prescription medications	0.9	1.4	4.2	-0.6	1.1	0.9	-0.9	-1.1	-2.0
Age when periods started (menarche)	0.6	1.4	3.0	1.6	1.7	0.3	0.8	1.2	0.5
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.3	0.6	-1.2	-1.5	0.2	-0.0	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.1	5.1	2.0	0.9	1.4	2.0	2.3	1.7
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	3.4	0.2	0.1	1.8	1.0	0.9	0.0
Qualifications: CSEs or equivalent	1.9	2.5	4.1	0.3	2.0	1.2	1.8	1.6	1.8
Serious illness, injury or assault to yourself	0.7	0.8	3.4	0.3	-0.5	1.9	0.5	0.5	-0.9
High blood pressure	0.8	2.3	4.7	0.3	0.8	1.4	2.2	2.2	1.4
Hayfever, allergic rhinitis or eczema	2.1	4.6	6.2	1.9	1.9	2.1	2.5	2.3	2.2
Multivitamins +/- minerals	0.6	0.8	2.4	-0.2	0.3	-1.6	-0.7	-1.0	-0.7
Stomach or abdominal pain in last month	0.6	0.8	1.5	0.9	-0.6	-0.6	-1.2	-1.2	-0.6
Supplements: Glucosamine	2.2	2.9	6.5	0.5	0.9	1.0	2.5	1.9	2.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.0	1.0	-0.2	1.0	0.0	-0.1	-0.5
Medication: Atenolol	2.1	2.7	4.6	1.3	0.0	2.1	1.9	1.9	1.6
Medication: Levothyroxine sodium	2.6	4.4	8.8	-2.7	-0.9	-0.4	-2.5	-3.0	-1.8
Sitting height	0.2	1.3	4.2	2.1	-0.7	0.9	1.1	0.8	0.7
Chronic bronchitis/emphysema (father)	0.3	0.4	0.9	0.2	-0.4	-1.0	-0.8	-0.6	-0.5
High blood pressure (mother)	3.9	5.4	12.0	-0.3	1.9	3.5	2.5	2.7	1.7
Body mass index (BMI)	0.3	1.5	3.0	-0.2	-0.5	-1.7	-1.5	-1.7	-0.6
Impedance of leg (left)	4.4	21.4	37.2	1.7	2.7	5.0	6.1	6.1	4.3
Leg predicted mass (left)	3.0	15.6	28.0	-0.7	-2.3	-4.4	-5.1	-5.3	-3.8
Trunk fat mass	0.0	0.2	0.8	0.4	-0.0	-0.9	-0.2	-0.4	0.3
Waist circumference	0.4	1.5	2.5	-0.5	-0.9	-1.3	-1.6	-1.5	-1.1
Number of incorrect matches in round	0.7	1.1	3.0	1.7	0.3	-1.4	-0.7	-1.1	-0.3
Past tobacco smoking	0.1	0.1	0.3	-0.5	0.2	-0.3	0.2	-0.4	0.0
Alcohol usually taken with meals	1.8	3.0	6.1	1.2	-0.9	0.5	2.2	2.5	2.1
Nervous feelings	0.0	0.0	0.1	-0.2	0.2	-0.1	-0.1	-0.3	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.6	-1.1	-0.4	-0.2	-1.1	-0.8	-1.3
Hearing difficulty/problems with background noise	4.3	6.9	13.6	-0.3	-1.8	-2.7	-3.0	-2.9	-3.7
Hair/balding pattern: Pattern 2	1.6	2.0	5.2	1.1	1.0	0.7	1.6	1.3	2.3
Had menopause	0.5	0.6	1.1	0.8	0.6	1.1	0.5	1.0	-0.1
Had other major operations	0.6	0.7	1.2	0.5	0.7	1.1	1.1	0.9	0.4
Forced vital capacity (FVC)	0.7	2.6	8.4	2.9	-0.2	1.3	1.6	1.2	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	4.4	0.9	0.1	0.9	1.6	2.1	1.4
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.3	0.6	1.1	0.8	0.1	0.4	0.7
Qualifications: None of the above	0.3	0.6	2.6	0.0	1.6	1.0	0.2	0.3	-0.3
Financial difficulties in last 2 years	1.1	1.4	4.8	0.7	2.2	-0.4	0.1	0.8	1.6
Mouth/teeth dental problems	0.3	0.5	1.9	0.2	0.8	1.4	0.3	0.0	0.3
Heart attack	0.6	0.7	3.7	0.2	1.9	-0.8	-0.1	0.0	-0.0
Allergy	1.6	3.6	4.5	-1.7	-1.3	-2.0	-2.1	-2.0	-2.1
Pain all over the body in last month	0.4	0.4	0.8	0.3	0.9	0.8	0.3	0.5	0.8
Diabetes (self-reported)	1.2	1.8	3.6	-1.0	-0.8	-0.0	-1.6	-1.7	-1.9
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.3	0.1	0.3	-0.2	0.5	0.3	0.5
Medication: Ramipril	2.0	2.5	5.0	0.8	-0.7	1.9	2.2	2.2	0.7
Medication: Simvastatin	0.3	0.4	1.4	0.7	1.2	0.3	0.5	0.1	0.5
Fluid intelligence score	0.3	0.7	2.2	-0.9	-1.5	-1.0	-0.4	-0.4	0.1
Illnesses of siblings	0.3	0.4	1.2	-0.0	0.5	-0.8	-0.1	-0.1	1.1
Neuroticism score	1.1	2.3	3.8	-1.4	-1.0	-1.5	-2.0	-1.8	-1.3
Weight	1.0	5.0	9.1	0.3	-1.3	-2.7	-2.8	-3.0	-2.0
Impedance of arm (right)	2.3	10.5	18.9	0.9	0.5	3.9	4.0	4.3	3.4
Arm fat percentage (right)	0.1	0.3	1.2	0.2	-0.0	-0.0	0.5	0.5	1.1
Trunk fat-free mass	3.0	17.2	29.8	-0.1	-2.5	-4.4	-5.2	-5.5	-4.6
Hip circumference	0.5	2.1	3.8	0.2	-0.8	-1.6	-1.8	-1.9	-1.4
Time employed in main current job	0.2	0.2	1.0	-1.0	0.2	0.1	-0.1	-0.2	-0.3
Alcohol intake versus 10 years previously	0.4	0.5	1.7	1.3	-0.0	1.1	-0.2	-0.3	-0.5
Father’s age at death	0.5	0.7	2.0	-1.4	-0.0	0.7	0.9	0.9	-0.4
Worrier / anxious feelings	0.5	1.0	2.3	0.0	-1.5	-1.4	-0.8	-0.9	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.7	1.0	-0.8	-1.3	-0.8	-0.4	0.4
Falls in the last year	0.7	1.0	2.8	-0.2	1.0	-0.7	-1.7	-1.2	-0.4
Hair/balding pattern: Pattern 3	1.6	2.4	4.8	-0.5	-0.9	-1.7	-1.8	-1.6	-2.2
Number of live births	0.3	0.5	1.3	-1.1	-1.1	-0.5	0.4	0.2	-0.1
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	5.7	2.4	-0.8	1.3	1.5	1.0	0.9
Pulse rate	0.7	1.2	2.1	1.2	-1.5	0.8	1.0	0.8	1.1
Happiness	0.9	1.1	2.4	-0.3	0.1	1.6	1.1	1.5	0.7
Noisy workplace	1.3	1.6	4.2	2.0	0.8	-0.7	-1.4	-1.3	-1.0
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.0	-1.2	-0.3	0.9	0.6	0.8	1.4
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	1.7	-0.9	0.2	0.8	1.3	1.0	1.3
Mouth/teeth dental problems: Dentures	0.4	0.7	1.6	1.2	-1.3	-0.2	0.5	0.9	0.0
Asthma	1.3	2.5	4.3	1.7	1.0	1.2	1.9	2.1	1.3
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.9	0.5	0.7	0.3	0.8	1.0	0.6
Medication: Cholesterol lowering	0.4	0.7	3.6	0.1	1.9	-0.5	0.3	0.1	-0.3
Depression (self-reported)	0.1	0.1	0.3	0.1	0.3	0.5	-0.0	0.0	-0.3
Medication: Lansoprazole	0.4	0.4	2.3	0.2	1.5	0.5	-0.2	-0.2	0.2
Prospective memory result	0.1	0.2	0.5	0.7	-0.1	0.6	-0.2	-0.1	-0.3
Lung cancer (father)	1.1	1.3	2.4	0.9	-1.6	0.6	-1.3	-1.1	-1.1
Illnesses of mother	6.2	7.6	13.0	-0.7	-1.8	-2.9	-3.4	-3.6	-3.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	2.3	1.5	-0.3	1.1	0.8	0.3	0.9
Pulse wave Arterial Stiffness index	0.9	1.0	2.7	0.2	-1.6	-0.3	-1.3	-1.2	-0.5
Impedance of arm (left)	2.6	12.3	22.3	0.6	0.9	3.9	4.5	4.7	3.9
Arm fat mass (right)	0.3	1.1	2.8	0.2	-0.8	-1.7	-1.2	-1.3	-0.4
Trunk predicted mass	3.0	17.2	29.5	-0.1	-2.5	-4.4	-5.2	-5.4	-4.6
Standing height	0.7	6.8	10.1	1.3	-2.0	-2.5	-2.9	-3.1	-3.2
Length of working week for main job	0.6	0.6	2.4	-1.5	-0.3	0.4	-0.5	-0.6	-0.7
Exposure to tobacco smoke at home	0.5	0.5	2.3	-0.8	-0.4	-1.5	-0.0	0.2	0.1
Breastfed as a baby	0.7	0.9	2.8	1.1	1.7	-0.1	0.6	0.8	0.6
Tense / ‘highly strung’	4.1	6.8	12.5	-2.3	0.7	-2.3	-3.5	-3.5	-2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	2.0	-0.8	0.5	-1.3	-1.3	-1.4	-1.1
Hair/balding pattern: Pattern 4	0.3	0.8	1.5	1.1	-0.1	0.6	1.2	1.2	-0.2
Birth weight of first child	0.1	0.3	0.8	-0.6	0.9	0.4	0.5	0.2	0.1
Peak expiratory flow (PEF)	0.7	1.7	3.1	0.8	-1.8	-1.2	-1.3	-1.3	-1.1
Pulse wave reflection index	0.8	0.9	2.1	-0.5	-1.2	-0.5	-1.4	-1.1	-0.5
Ever highly irritable/argumentative for 2 days	1.4	1.7	3.1	-0.7	-0.8	-0.6	-1.8	-1.7	-1.7
Loud music exposure frequency	0.7	0.8	1.9	-1.1	1.4	0.7	0.3	0.4	0.8
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	2.5	0.5	0.3	1.0	1.3	1.1	1.6
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.6	-0.6	-0.8	-0.4	-0.4	-0.4	0.5
Blood clot in the leg (DVT)	0.4	0.5	1.4	0.4	-1.1	-1.2	-0.4	-0.2	0.2
Medication: Paracetamol	2.0	3.2	6.0	1.1	-0.2	1.9	2.5	2.5	1.6
Headache pain in last month	0.8	1.4	2.6	0.9	-1.4	-0.1	-1.0	-1.4	-1.6
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	1.8	-0.8	-1.3	-0.1	-1.3	-1.1	-0.7
Glaucoma (self-reported)	0.4	0.4	0.9	1.0	0.2	0.7	0.6	0.8	0.4
Gout (self-reported)	0.9	1.2	2.1	-0.9	-0.4	-1.0	-1.5	-1.4	-1.0
Hypothyroidism/myxoedema (self-reported)	3.2	6.2	14.4	-1.6	-1.0	-1.3	-3.1	-3.8	-2.7
Medication: Amlodipine	3.2	4.5	6.5	1.6	2.5	1.5	2.5	2.6	1.8
Medication: Ventolin 100micrograms inhaler	0.3	0.3	0.9	1.0	0.5	0.5	0.3	0.3	-0.7
Birth weight	0.3	0.6	1.5	0.7	1.2	-0.3	-0.5	-0.6	-0.9
Chronic bronchitis/emphysema (mother)	0.9	1.1	2.3	0.4	-0.3	0.7	1.5	1.2	1.4
High blood pressure (siblings)	0.6	0.8	3.4	0.0	0.0	1.8	0.8	0.9	0.1
Forced vital capacity (FVC), Best measure	0.4	1.3	5.1	2.3	-0.2	1.1	0.6	0.3	1.0
Body fat percentage	0.5	2.0	4.5	0.4	0.7	0.7	1.8	1.8	2.1
Leg fat percentage (right)	0.7	2.5	4.6	0.7	0.8	1.1	2.1	2.1	1.9
Arm fat-free mass (right)	2.6	13.5	23.7	-0.6	-1.8	-4.4	-4.5	-4.9	-3.8
Exposure to tobacco smoke outside home	1.0	1.4	2.5	-1.5	-0.3	-0.7	-1.3	-1.1	-1.6
Comparative body size at age 10	1.4	4.0	6.5	-2.3	-1.9	-1.8	-2.6	-1.9	-1.4
Number of full brothers	0.1	0.2	0.7	0.2	-0.8	-0.1	-0.3	-0.5	-0.3
Worry too long after embarrassment	4.3	7.2	11.9	-2.2	-0.9	-2.8	-3.4	-3.2	-2.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.3	-0.2	-0.5	-0.6	-1.2	-1.4	-1.5
Wheeze or whistling in the chest in last year	0.2	0.3	1.0	0.4	-0.2	-0.5	-0.7	-0.3	-1.0
Number of children fathered	0.6	0.6	2.2	-0.8	0.5	0.4	-0.4	-0.5	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.8	0.6	-0.9	-0.6	-0.1	-0.1	0.2
Age at first live birth	0.5	0.9	2.0	0.6	-0.3	0.6	1.4	1.4	0.9
Pulse wave peak to peak time	0.8	0.9	2.3	0.1	1.5	0.2	1.3	1.2	0.4
Health satisfaction	0.5	0.7	1.6	-1.2	0.8	1.3	-0.1	0.2	-0.4
Shortness of breath walking on level ground	0.4	0.4	1.2	-1.0	0.3	1.1	0.1	0.3	-0.4
Qualifications: College or University degree	1.2	3.9	6.3	-1.6	-1.2	-1.7	-2.5	-2.4	-2.0
Eye problems/disorders: None of the above	0.6	0.7	1.6	0.1	-1.3	0.2	-1.0	-1.0	-0.6
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.7	-0.8	-1.3	-1.1	-0.8	-0.6	-0.2
Emphysema/chronic bronchitis	0.7	0.8	2.1	-0.0	-1.4	0.2	-1.2	-0.9	-0.6
Medication for pain relief, constipation, heartburn	2.1	3.6	7.0	-1.1	-0.6	-2.6	-2.1	-2.2	-1.9
Neck or shoulder pain in last month	0.7	1.0	2.8	0.2	0.2	1.7	1.3	1.1	0.2
Medication: Blood pressure	2.4	4.3	8.4	1.0	1.5	0.9	2.8	2.9	2.3
Angina (self-reported)	0.4	0.5	1.3	-0.1	1.1	0.8	0.7	0.7	0.2
Migraine (self-reported)	0.2	0.3	0.9	-0.3	0.5	-0.1	-0.1	-0.6	-0.9
Medication: Ibuprofen	0.1	0.1	0.5	-0.2	0.7	0.4	0.2	0.3	-0.3
Medication: Allopurinol	2.0	2.6	5.4	-1.2	-1.0	-1.0	-2.1	-2.3	-1.5
Medication: Omeprazole	0.8	1.0	3.2	0.1	-0.1	1.8	1.2	1.1	-0.1
Medication: Seretide 50 evohaler	4.9	5.6	8.5	2.4	-0.4	2.9	2.6	2.8	2.2
Mean time to correctly identify matches	1.2	2.3	5.6	-1.5	-0.8	-1.6	-1.2	-1.2	-2.4
Heart disease (mother)	4.6	5.6	12.1	1.4	1.1	1.3	2.9	3.5	2.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.6	1.6	-0.6	0.8	0.1	-0.2	-0.2
Whole body fat mass	0.1	0.2	0.8	0.1	-0.1	-0.9	-0.3	-0.5	0.2
Leg fat mass (right)	0.0	0.2	0.8	0.0	0.0	-0.9	-0.3	-0.3	0.1
Arm predicted mass (right)	2.3	11.6	20.6	-0.5	-1.5	-4.1	-4.2	-4.5	-3.5
Pulse rate, automated reading	0.8	2.6	4.3	2.0	-0.5	0.5	2.1	1.9	1.8
Alcohol intake frequency.	0.8	1.9	7.7	0.5	-0.4	2.8	1.5	0.8	0.7
Comparative height size at age 10	0.7	3.7	8.8	-0.0	-1.0	-0.9	-2.1	-2.6	-3.0
Number of full sisters	0.4	0.5	0.9	0.6	-0.3	0.9	-0.5	-1.0	-0.8
Suffer from ‘nerves’	2.0	3.2	6.2	-2.5	-1.8	-1.4	-1.5	-1.5	-1.8
Overall health rating	0.0	0.1	0.2	-0.4	-0.2	0.5	0.0	0.1	-0.3
Chest pain or discomfort	0.6	0.9	2.8	-0.1	-0.2	0.0	-1.7	-1.1	-1.2
Had major operations	1.1	1.3	2.9	-1.0	1.7	-1.4	-0.9	-0.8	-0.6
Age at last live birth	0.1	0.1	0.2	-0.3	-0.4	-0.3	0.2	0.2	-0.3
Family relationship satisfaction	0.2	0.3	1.0	-0.2	-0.6	1.0	0.0	0.2	-0.3
Leg pain on walking	0.6	0.7	1.5	-1.2	-1.0	1.0	0.2	0.1	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.3	0.2	-1.0	0.2	0.1	-0.0	-1.1
Commuting to job workplace: Car/motor vehicle	4.2	4.8	7.7	-0.2	0.9	-2.7	-2.6	-2.4	-2.8
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.8	-0.6	-1.0	-0.8	-1.0	-1.3	-1.0
Medication: Aspirin	0.4	0.5	0.9	0.7	0.9	0.9	0.4	0.6	0.5
Supplements: Vitamin C	0.1	0.1	0.4	0.3	0.4	-0.6	-0.1	-0.0	0.4
Knee pain experienced in last month	0.1	0.2	1.2	-0.3	-1.1	-0.2	0.1	0.1	-0.2
Hypertension (Self-reported)	0.9	2.5	5.0	0.6	0.7	1.5	2.2	2.2	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.7	-0.2	-1.3	1.2	0.1	0.4	-0.5
Illnesses of father: Heart disease	0.1	0.1	0.2	-0.5	0.4	0.1	-0.0	-0.3	-0.1
Illnesses of siblings: Diabetes	0.6	0.7	1.4	0.1	-1.2	-1.0	-0.7	-0.6	-0.9
Smoking status: Previous	0.3	0.4	0.8	0.7	0.6	0.9	0.2	0.8	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	2.9	0.7	0.5	-1.6	-1.5	-1.7	-1.3
Whole body fat-free mass	3.2	18.3	31.9	-0.4	-2.6	-4.7	-5.4	-5.7	-4.5
Leg fat-free mass (right)	3.4	18.0	32.3	-0.9	-2.5	-4.7	-5.5	-5.7	-4.0
Arm fat percentage (left)	0.1	0.5	2.0	0.1	0.2	-0.0	0.7	0.7	1.4
Average weekly red wine intake	1.0	1.4	3.7	-0.8	-1.5	-1.9	-1.1	-0.7	-0.4
Handedness (chirality/laterality): Left-handed	4.3	5.1	8.5	1.8	-0.5	2.0	2.9	2.8	2.6
Mood swings	1.0	1.8	3.5	-1.9	-0.8	-1.4	-1.3	-1.1	-1.4
Loneliness, isolation	2.0	2.8	4.1	2.0	1.2	0.7	1.9	1.9	1.9
Long-standing illness, disability or infirmity	0.8	1.3	2.9	0.6	-1.5	1.7	-0.1	0.1	-1.4
Ever had bowel cancer screening	2.7	3.2	4.8	-1.4	-1.6	-1.2	-2.2	-2.0	-2.1
Diabetes diagnosed by doctor	0.2	0.4	0.9	-0.7	-0.2	1.0	-0.2	-0.2	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.3	4.6	0.0	2.1	1.8	1.7	1.2	1.3
Friendships satisfaction	0.3	0.4	0.6	-0.8	0.4	0.8	0.4	0.6	0.5
Qualifications: nursing, teaching	1.8	2.9	5.3	1.3	-1.1	1.1	2.1	2.3	1.9
Commuting to job workplace: Walk	0.3	0.3	0.7	0.5	-0.4	0.1	0.5	0.8	0.6
Eye problems/disorders: Cataract	1.8	2.1	4.3	-0.0	0.7	1.6	2.1	2.0	1.2
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.8	0.9	-0.7	-0.4	0.1	0.2	-0.3
Medication for cholesterol	0.5	0.8	1.7	-0.6	0.4	-1.3	-0.8	-0.9	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	4.1	2.0	0.0	-0.1	0.5	0.2	1.2
Back pain experienced in last month	4.7	6.9	14.3	1.2	0.4	2.2	3.6	3.8	2.8
Mineral and other dietary supplements	1.0	1.3	3.4	-0.1	-0.0	-1.1	-1.9	-1.3	-1.2
Breast cancer (self-reported)	0.6	0.7	2.2	1.5	-1.1	-0.8	-0.1	-0.4	0.1
Asthma (self-reported)	1.3	2.5	4.9	1.6	0.9	1.0	2.1	2.2	1.3
Osteoporosis (self-reported)	0.6	0.7	2.9	-1.7	0.7	0.1	-0.8	-0.3	-0.1
Osteoarthritis (self-reported)	0.3	0.4	1.2	-0.7	-0.8	1.1	0.3	0.1	-0.4
Medication: Aspirin	0.2	0.3	1.0	0.4	1.0	0.7	-0.0	0.2	0.5
Medication: Gliclazide	0.6	0.7	1.3	-1.1	0.1	0.4	-1.1	-0.8	-0.8
Illnesses of father: None of the above (group 1)	0.8	1.0	2.4	0.0	-0.1	-1.3	-1.5	-1.3	-0.3
Smoking status: Current	0.7	1.1	2.3	-0.4	-0.8	-1.1	-1.5	-1.4	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.2	4.6	2.1	-0.2	1.7	1.6	1.4	1.1
Whole body water mass	3.2	18.5	32.6	-0.4	-2.6	-4.7	-5.4	-5.7	-4.5
Leg predicted mass (right)	3.4	18.0	32.3	-0.9	-2.5	-4.7	-5.5	-5.7	-4.0
Arm fat mass (left)	0.2	0.8	2.1	0.1	-0.8	-1.5	-0.9	-1.1	-0.3
Number of self-reported non-cancer illnesses	0.1	0.2	0.6	-0.4	0.8	0.3	0.1	-0.2	-0.6
Average weekly champagne plus white wine intake	0.5	0.7	0.9	-0.8	-0.7	-1.0	-1.0	-0.8	-0.8
Miserableness	0.1	0.2	0.7	-0.8	0.2	0.2	-0.6	-0.4	-0.5
Guilty feelings	3.3	5.0	7.6	0.0	-1.9	-2.0	-2.8	-2.7	-2.6
Wears glasses or contact lenses	3.2	3.7	8.7	-0.1	-1.4	2.0	2.6	3.0	1.0
Ever taken oral contraceptive pill	0.2	0.2	0.9	-0.3	0.0	-0.9	-0.3	-0.4	0.1
Hearing aid user	0.3	0.3	0.6	-0.2	0.2	-0.3	-0.6	-0.8	-0.8
Mother’s age at death	0.5	0.7	2.0	1.0	1.4	0.2	-0.1	0.6	0.9
Financial situation satisfaction	1.9	2.3	4.1	-1.1	2.0	1.2	1.3	2.0	1.1
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.8	0.1	-0.7	-1.0	-1.2	-1.4	-0.7
Commuting to job workplace: Public transport	3.0	3.6	6.1	1.1	-0.2	1.8	2.3	2.5	2.3
Eye problems/disorders: Glaucoma	0.4	0.4	0.6	-0.1	0.7	0.6	0.8	0.8	0.7
Medication: Blood pressure	2.2	4.1	6.2	2.1	-1.2	2.5	2.3	2.2	1.6
Pain type(s) experienced in last month: Hip pain	2.1	2.6	5.2	-0.0	-2.3	-1.1	-1.7	-1.8	-1.7
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.2	0.4	0.1	1.2	1.5	0.9	0.8
High cholesterol (Self-reported)	0.2	0.3	1.0	-0.3	0.2	-1.0	0.5	0.1	0.7
Medication: Bendroflumethiazide	2.5	3.7	7.2	1.7	-0.7	1.4	2.7	2.7	1.7
Medication: Paracetamol	3.1	4.8	8.0	1.2	0.2	2.7	2.8	2.8	2.0
Medication: Lisinopril	0.8	1.1	1.9	1.4	0.2	0.4	1.2	1.1	1.3
Medication: Atorvastatin	0.2	0.2	0.5	-0.2	0.1	-0.1	0.6	0.7	0.6
Illnesses of father: High blood pressure	0.5	0.6	2.1	0.2	0.6	1.5	0.8	0.8	0.2
Alcohol drinker status: Never	0.7	0.8	1.6	0.2	-1.3	1.0	-0.4	-0.8	-1.2
Ever smoked	0.2	0.3	1.1	0.2	-1.0	-0.1	-0.7	-0.2	-0.6
Basal metabolic rate	2.5	13.7	24.6	-0.2	-2.1	-4.2	-4.7	-5.0	-3.7
Leg fat percentage (left)	0.5	1.9	3.4	0.6	0.6	0.9	1.9	1.9	1.8
Arm fat-free mass (left)	2.3	11.5	20.1	0.0	-2.0	-3.9	-4.1	-4.5	-3.6
Number of operations (self-reported)	0.2	0.3	0.7	-0.7	0.6	-0.2	-0.0	-0.1	-0.8
Average weekly beer plus cider intake	0.6	0.8	3.8	0.8	0.6	2.0	-0.1	-0.1	0.4
Irritability	3.7	6.3	11.4	-1.7	-0.2	-3.4	-3.4	-3.1	-1.6
Risk taking	3.6	5.2	11.9	-0.4	0.3	-2.3	-3.4	-3.2	-2.0
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.1	0.6	1.0	1.0	0.5	0.8	-0.2
Fractured/broken bones in last 5 years	1.0	1.3	3.7	1.2	0.2	-0.3	-1.1	-1.2	-1.9
Age started oral contraceptive pill	0.7	0.9	1.8	1.1	-0.2	-0.2	1.3	1.0	1.1
Diastolic blood pressure, automated reading	1.0	3.0	5.3	-0.6	0.4	2.3	2.0	2.1	2.0
Ever depressed for a whole week	0.3	0.3	0.7	0.6	0.2	0.9	0.4	0.6	0.7
Unable to work because of sickness or disability	1.0	1.3	3.0	1.7	-1.7	0.9	0.7	0.8	-0.6
Commuting to job workplace: Cycle	0.9	1.1	3.6	0.5	-0.4	1.9	0.7	0.9	1.3
Myopia	4.3	6.2	12.9	2.9	-1.4	1.4	2.3	2.6	3.6
Vascular/heart problems diagnosed by doctor	0.7	1.9	3.9	-0.3	-0.8	-1.2	-2.0	-1.9	-1.3
Cholesterol lowering medication	0.7	1.0	2.8	-0.0	0.1	0.9	1.1	1.1	1.7
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	4.0	-0.2	0.5	2.0	1.5	1.7	0.2
Pain experienced in last month	0.0	0.0	0.1	0.1	-0.1	0.4	0.0	0.2	0.2
Supplements: Calcium	0.8	0.9	3.3	-1.8	0.3	0.4	-1.0	-0.8	-0.1
Basal cell carcinoma (self-reported)	0.3	0.4	0.9	0.1	-0.9	-1.0	0.5	0.6	0.0
Heart attack/myocardial infarction (self-reported)	0.5	0.6	2.3	0.6	1.5	-0.9	-0.1	0.0	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.4	0.4	-1.2	-1.2	-0.2	-0.1	0.2
Heart disease (siblings)	0.5	0.6	2.4	-0.1	-0.9	1.6	0.3	0.5	-0.0
Alcohol drinker status: Previous	0.8	0.9	1.6	-0.1	-1.3	0.7	-1.1	-1.0	-0.9
Pack years of smoking	0.3	0.5	1.2	0.3	0.7	-0.3	-1.1	-0.9	-0.5
Impedance of whole body	4.1	20.7	36.3	1.2	2.3	4.9	5.8	6.0	4.8
Leg fat mass (left)	0.1	0.4	1.3	-0.0	-0.1	-1.1	-0.6	-0.7	-0.2
Arm predicted mass (left)	2.5	12.8	22.2	-0.3	-1.8	-4.2	-4.3	-4.7	-3.8