TWAS hub - LSM1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.1667	0.0570	5.0e-05	0.101	NA	0.169	NA	0.107	1.8e-04	NA	1.1e-06	NA	1.2e-04
2	ROSMAP	Brain Pre-frontal Cortex	0.0927	0.0237	5.0e-16	0.165	0.125	0.146	0.143	0.159	1.0e-20	9.0e-16	2.7e-18	5.6e-18	7.3e-20
3	YFS	Blood	0.0170	0.0079	2.7e-04	0.004	0.009	0.006	0.009	0.007	1.0e-02	4.2e-04	2.5e-03	4.1e-04	1.8e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Systolic Blood Pressure	9.7	48.8	56.7	-6.5	-7.5	-6.9
Illnesses of mother	9.7	12.0	13.3	3.1	3.6	3.6
Bipolar Disorder or Schizophrenia	9.5	23.2	29.7	5.3	5.4	3.5
Average weekly spirits intake	9.3	11.5	14.7	2.9	3.8	3.4
Bipolar Disorder (2018)	8.6	13.6	17.9	3.8	4.2	2.9
Hearing difficulty/problems: Yes	8.2	12.5	16.9	2.8	4.1	3.6
Back pain experienced in last month	7.8	11.4	12.8	-3.1	-3.6	-3.5
Risk taking	7.0	10.3	13.0	3.6	3.3	2.6
High blood pressure (mother)	6.9	9.7	14.5	-2.6	-2.8	-3.8
Hearing difficulty/problems with background noise	6.9	11.1	13.2	3.6	3.2	3.1
Impedance of leg (right)	6.5	31.5	37.2	-4.9	-5.8	-6.1
Worry too long after embarrassment	6.2	10.4	14.9	3.9	3.1	2.5
Impedance of leg (left)	5.9	28.7	37.1	-4.4	-5.4	-6.1
Handedness (chirality/laterality): Left-handed	5.7	6.8	8.2	-2.4	-2.6	-2.9
Heart disease (mother)	5.6	6.8	8.1	-2.6	-2.9	-2.3
Schizophrenia (2014)	5.4	12.0	15.1	3.9	3.6	2.7
Medication: Levothyroxine sodium	5.4	9.1	14.8	1.9	2.9	3.9
Ever had bowel cancer screening	5.4	6.4	8.7	2.2	2.4	2.9
Impedance of whole body	5.4	27.2	32.0	-4.3	-5.6	-5.7
Systolic blood pressure, automated reading	5.3	15.4	16.2	-3.7	-4.0	-4.0
Hypothyroidism/myxoedema (self-reported)	5.3	10.3	15.8	1.6	3.5	4.0
Schizophrenia (2018)	5.2	10.7	14.4	3.8	3.6	2.3
Wears glasses or contact lenses	5.1	5.9	7.0	-2.6	-2.1	-2.5
Leg fat-free mass (right)	5.0	26.9	34.7	4.3	5.2	5.9
Leg predicted mass (right)	5.0	26.6	34.3	4.3	5.2	5.9
Commuting to job workplace: Car/motor vehicle	4.9	5.6	8.1	2.4	2.8	1.7
Tense / ‘highly strung’	4.7	7.8	8.5	2.7	2.9	2.8
Whole body water mass	4.6	26.3	34.1	4.2	5.2	5.8
Whole body fat-free mass	4.5	25.5	32.9	4.1	5.2	5.7
Lung FVC	4.4	22.2	23.2	-4.8	-4.8	-4.6
Medication: Seretide 50 evohaler	4.4	5.1	7.4	-2.7	-2.4	-1.4
Mean Putamen Volume	4.3	4.9	6.8	1.5	2.4	2.6
Hypothyroidism (self reported)	4.3	9.9	13.5	1.9	3.6	3.7
Leg fat-free mass (left)	4.3	22.5	31.6	3.7	4.7	5.6
Leg predicted mass (left)	4.3	22.6	31.3	3.7	4.7	5.6
Trunk fat-free mass	4.2	24.3	30.6	4.1	5.0	5.5
Trunk predicted mass	4.2	24.1	30.5	4.1	5.0	5.5
Medication: Amlodipine	4.2	5.8	6.1	-2.5	-2.3	-2.4
Medication: Bendroflumethiazide	4.1	6.2	7.7	-2.7	-2.8	-1.9
Commuting to job workplace: Public transport	4.0	4.8	6.1	-2.1	-2.5	-1.9
Qualifications: CSEs or equivalent	3.9	5.1	9.7	-1.4	-2.0	-3.1
Irritability	3.8	6.5	7.6	2.1	2.8	2.7
Ever highly irritable/argumentative for 2 days	3.7	4.4	5.7	2.0	2.4	1.8
Arm fat-free mass (right)	3.5	17.9	22.7	3.4	4.4	4.8
Basal metabolic rate	3.5	19.6	26.9	3.5	4.5	5.2
Supplements: Glucosamine	3.3	4.3	7.3	-0.8	-2.2	-2.7
Impedance of arm (left)	3.3	15.1	19.4	-3.0	-4.4	-4.1
Medication: Blood pressure	3.3	5.9	8.0	-2.4	-2.8	-2.0
Arm predicted mass (left)	3.3	16.8	21.8	3.1	4.3	4.7
Rheumatoid Arthritis	3.2	4.3	7.6	2.8	2.1	1.0
Allergy or Eczema	3.2	8.3	10.9	-2.5	-3.3	-2.8
Medication: Paracetamol	3.2	5.0	6.2	-2.5	-2.1	-2.0
Arm predicted mass (right)	3.0	15.4	19.3	3.2	4.1	4.4
Eye problems/disorders: Cataract	3.0	3.5	4.2	-1.5	-2.0	-2.1
Arm fat-free mass (left)	3.0	15.2	20.0	3.0	4.1	4.5
Chronic bronchitis/emphysema (mother)	2.9	3.4	8.0	-0.8	-1.3	-2.8
Medication: Blood pressure	2.9	5.6	7.2	-2.7	-2.4	-2.0
Pain type(s) experienced in last month: Hip pain	2.9	3.6	4.1	1.7	2.0	2.0
Myopia	2.8	4.0	5.5	-2.3	-2.2	-1.2
Impedance of arm (right)	2.7	12.5	15.6	-2.8	-4.0	-3.8
Irritable Bowel Disease (IBD)	2.6	6.3	7.0	2.4	2.4	2.6
Hair/balding pattern: Pattern 2	2.6	3.4	7.3	-2.7	-1.3	-1.0
Hair/balding pattern: Pattern 3	2.6	3.9	5.6	2.0	1.4	2.4
Guilty feelings	2.6	3.9	5.1	1.8	2.3	1.8
Ulcerative Colitis	2.5	3.6	4.9	1.4	1.9	2.2
Alcohol usually taken with meals	2.5	4.1	4.5	-1.8	-2.1	-2.1
Ulcerative Colitis (UC)	2.4	4.6	5.9	2.0	1.9	2.4
Hayfever, allergic rhinitis or eczema	2.4	5.3	7.4	-1.5	-2.5	-2.7
Noisy workplace	2.4	2.9	3.8	1.9	1.6	1.6
Diabetes (father)	2.2	2.7	3.2	-1.7	-1.4	-1.8
Medication: Atenolol	2.2	2.7	3.8	-1.7	-1.9	-1.3
Medication for pain relief, constipation, heartburn	2.2	3.8	6.8	0.9	1.9	2.6
Qualifications: nursing, teaching	2.2	3.5	5.7	-0.9	-2.4	-2.0
Medication: Ramipril	2.1	2.7	3.1	-1.7	-1.8	-1.4
Happiness	2.1	2.6	5.7	-0.7	-1.2	-2.4
Qualifications: College or University degree	2.1	6.7	8.5	2.9	2.5	2.3
Severe depression (siblings)	2.0	2.3	4.5	2.1	1.0	1.2
Medication: Paracetamol	2.0	3.4	3.7	-1.9	-1.8	-1.8
Diastolic blood pressure, automated reading	2.0	6.2	10.8	-1.9	-2.1	-3.3
Supplements: Calcium	2.0	2.2	6.1	2.5	0.7	0.0
Comparative body size at age 10	1.9	5.3	8.8	1.3	2.3	3.0
Hypertension (Self-reported)	1.9	5.4	6.4	-2.5	-2.5	-1.9
Ever had stillbirth, spontaneous miscarriage or termination	1.9	2.0	3.6	-1.0	-1.2	-1.9
Financial situation satisfaction	1.9	2.4	2.9	-1.4	-1.4	-1.7
Worry (Nagel 2018)	1.8	3.8	5.1	1.6	1.9	2.3
Height	1.8	35.3	42.4	5.5	5.8	6.5
Medication for hormone replacement therapy	1.8	2.0	4.2	2.0	1.1	0.8
High blood pressure	1.8	4.9	6.3	-2.4	-2.5	-1.6
Diabetes (self-reported)	1.8	2.8	3.3	1.6	1.5	1.8
Smoking Status	1.7	4.0	4.1	2.0	2.0	2.0
Cardiovascular Disease	1.7	5.6	7.1	-2.5	-2.7	-1.9
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	2.4	-1.3	-1.3	-1.5
Stomach or abdominal pain in last month	1.7	2.2	3.7	1.9	1.3	1.1
High blood pressure (siblings)	1.7	2.5	4.4	-1.6	-0.7	-2.1
Pulse wave Arterial Stiffness index	1.6	1.9	4.6	0.5	1.0	2.1
Pulse wave peak to peak time	1.6	1.9	4.8	-0.2	-0.9	-2.2
Medication: Allopurinol	1.6	2.1	4.4	0.9	2.1	1.0
Loneliness, isolation	1.6	2.2	3.6	-0.4	-1.9	-1.7
Neuroticism	1.5	3.6	4.3	1.8	1.9	2.1
Weight	1.5	7.2	12.6	1.6	2.6	3.6
Tinnitus: Yes, now most or all of the time	1.5	1.8	3.1	1.8	1.1	1.0
Current tobacco smoking	1.4	2.3	4.0	2.0	1.5	0.8
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	3.4	1.1	-0.9	-1.9
Leg fat percentage (right)	1.4	5.2	10.0	-3.2	-2.2	-0.9
Pulse rate, automated reading	1.4	4.5	7.3	-1.8	-1.7	-2.7
Suffer from ‘nerves’	1.4	2.1	3.4	1.0	1.4	1.9
Medication: Lisinopril	1.4	1.8	3.3	-0.1	-1.4	-1.8
Vascular/heart problems diagnosed by doctor	1.4	3.9	5.4	2.2	2.3	1.2
Neuroticism (Nagel 2018)	1.3	3.0	3.0	1.7	1.7	1.7
Crohns Disease (2017)	1.3	2.9	3.0	1.7	1.6	1.7
Vitamin and mineral supplements	1.3	1.7	2.3	-1.3	-1.1	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	1.3	3.0	5.3	-1.0	-2.3	-1.6
Allergy	1.3	3.1	4.8	0.8	1.9	2.2
Neuroticism score	1.3	2.8	3.1	1.8	1.7	1.6
Headache pain in last month	1.3	2.2	4.2	2.1	1.4	0.4
Illnesses of siblings: Diabetes	1.3	1.7	2.4	1.6	1.0	1.2
Smoking status: Current	1.3	2.0	3.6	1.9	1.4	0.7
Intelligence (Savage-Jansen 2018)	1.2	3.6	6.1	2.5	1.5	1.5
Crohns Disease (2012)	1.2	2.0	3.2	1.8	1.4	1.0
Pulse wave reflection index	1.2	1.5	3.9	0.3	0.8	2.0
Eye problems/disorders: None of the above	1.2	1.4	2.2	1.1	0.8	1.5
Supplements: Zinc	1.1	1.2	3.0	1.7	0.8	0.1
Had menopause	1.1	1.4	2.7	1.2	-0.1	-1.7
Chest pain or discomfort	1.1	1.5	1.9	1.4	1.1	1.2
Mineral and other dietary supplements	1.1	1.5	2.5	0.5	1.6	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.4	2.7	-1.3	-1.6	-1.6
Age started oral contraceptive pill	1.1	1.4	1.9	-1.4	-1.1	-1.0
Alcohol drinker status: Previous	1.1	1.2	2.1	1.4	0.9	0.8
Fed-up feelings	1.0	1.9	2.1	-1.2	-1.5	-1.4
Chronic bronchitis/emphysema (father)	1.0	1.2	2.8	-0.4	0.8	1.7
Standing height	1.0	10.3	11.1	3.3	3.0	3.3
Birth weight of first child	1.0	1.9	4.4	-2.1	-0.7	-0.8
Peak expiratory flow (PEF)	1.0	2.4	4.1	2.0	1.3	1.2
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.9	-0.2	0.7	1.7
Emphysema/chronic bronchitis	1.0	1.1	1.9	0.8	1.0	1.4
Medication: Ibuprofen	1.0	1.1	2.4	1.0	-0.4	-1.5
Mean time to correctly identify matches	1.0	1.9	3.4	1.0	1.1	1.9
Leg fat percentage (left)	1.0	3.7	7.4	-2.7	-1.8	-0.7
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	1.9	-1.3	-1.4	-0.5
Major Depression (MDD)	0.9	1.1	1.8	0.0	1.3	1.3
Neuroticism (2016)	0.9	1.3	2.4	1.5	1.2	0.1
Taking other prescription medications	0.9	1.4	1.7	1.1	1.3	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	3.2	-0.7	-1.8	-1.6
Hip circumference	0.9	3.8	6.8	1.1	1.8	2.6
Lung cancer (father)	0.9	1.1	1.6	1.1	0.6	1.3
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	1.8	-1.2	-1.3	-1.0
Body fat percentage	0.9	3.5	6.2	-2.5	-1.9	-0.7
Comparative height size at age 10	0.9	5.1	7.6	2.8	2.1	1.8
Illnesses of father: None of the above (group 1)	0.9	1.1	1.7	1.0	0.8	1.3
Pack years of smoking	0.9	1.3	2.7	1.6	1.0	0.5
Age at First Birth	0.8	1.1	1.8	-0.5	-1.3	-1.2
Lupus	0.8	1.1	1.5	1.2	1.1	0.8
Blood Red Count	0.8	7.6	15.3	1.4	2.4	3.9
Pack years adult smoking proportion	0.8	1.2	2.6	1.6	1.0	0.3
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	2.1	-0.2	-0.6	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	1.7	1.1	0.8	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	1.1	1.0	1.0	1.0
Medication: Omeprazole	0.8	0.9	2.1	-1.4	-0.8	0.0
Mood swings	0.8	1.4	1.7	0.9	1.2	1.3
Medication: Gliclazide	0.8	0.9	2.1	0.3	0.7	1.5
Blood White Count	0.7	5.3	6.6	-2.6	-2.5	-1.8
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.1	1.4	0.6	0.4
Multivitamins +/- minerals	0.7	0.9	1.6	0.4	1.0	1.3
Waist circumference	0.7	2.6	4.8	0.8	1.5	2.2
Forced vital capacity (FVC)	0.7	2.6	3.8	-1.3	-1.9	-1.5
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.2	-0.1	-1.1	-1.1
Breastfed as a baby	0.7	0.9	1.3	-1.0	-1.1	-0.7
Gout (self-reported)	0.7	0.9	2.2	0.6	1.5	0.4
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.1	0.6	1.0	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	1.7	1.3	1.2	1.0
Average weekly champagne plus white wine intake	0.7	0.9	1.4	1.2	1.1	0.5
Illnesses of father: High blood pressure	0.7	0.8	1.9	-0.6	-0.4	-1.4
Fasting Glucose	0.6	0.7	1.3	-1.1	-0.7	0.5
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.1	0.9	1.1	0.5
Number of treatments/medications taken	0.6	1.0	1.3	-0.7	-1.1	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.5	0.6	0.9	1.2
Pulse rate	0.6	1.0	2.0	-0.6	-0.7	-1.4
Asthma	0.6	1.1	2.0	-0.4	-1.4	-1.1
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	1.7	0.8	1.3	0.7
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.1	-1.0	0.1	1.0
Neck or shoulder pain in last month	0.6	0.8	1.2	-0.7	-0.9	-1.1
Alcohol intake frequency.	0.6	1.3	2.3	-1.5	-1.3	-0.4
Number of full sisters	0.6	0.8	1.0	1.0	0.8	0.8
Asthma (self-reported)	0.6	1.2	2.1	-0.6	-1.4	-1.1
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.3	0.0	-1.2	-1.0
Commuting to job workplace: Cycle	0.6	0.7	1.2	-0.3	-0.9	-1.1
Primary Biliary Cirrhosis	0.5	0.8	1.2	1.1	0.2	-1.0
Ever had hysterectomy (womb removed)	0.5	0.5	1.0	0.3	0.7	1.0
Medication: Metformin	0.5	0.7	1.9	0.1	0.3	1.4
Trunk fat percentage	0.5	2.2	4.0	-2.0	-1.5	-0.3
Age when periods started (menarche)	0.5	1.2	1.7	-1.3	-1.2	-0.6
Body mass index (BMI)	0.5	2.1	4.5	0.1	1.3	2.1
Fluid intelligence score	0.5	1.0	1.6	1.3	0.2	1.1
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	2.6	-1.0	-1.6	-1.3
Wheeze or whistling in the chest in last year	0.5	1.0	2.2	-0.5	0.7	1.5
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.3	-1.2	-0.0	0.7
Average weekly red wine intake	0.5	0.7	1.0	1.0	1.0	0.4
Friendships satisfaction	0.5	0.7	1.1	-1.1	-0.9	-0.0
Basal cell carcinoma (self-reported)	0.5	0.6	1.1	1.0	-0.7	-0.6
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.8	1.0	0.1	1.3
Body Mass Index (BMI) (2010)	0.4	0.5	1.3	1.1	0.6	-0.2
Heel T-Score	0.4	3.0	5.4	-1.4	-2.3	-1.3
BMI	0.4	2.2	2.9	1.2	1.5	1.7
Respiratory disease	0.4	0.8	1.0	-0.7	-1.0	-0.9
Type 2 Diabetes (T2D) (2018)	0.4	0.7	2.0	0.3	0.1	1.4
Tanning	0.4	4.9	6.5	-1.6	-2.3	-2.5
Ever used hormone-replacement therapy (HRT)	0.4	0.5	0.8	0.7	0.9	0.3
Medication: Co-codamol	0.4	0.5	1.5	-0.2	-0.2	-1.2
Serious illness, injury or assault to yourself	0.4	0.5	1.6	-1.3	-0.0	-0.1
Number of incorrect matches in round	0.4	0.7	1.7	0.7	0.2	1.3
Father’s age at death	0.4	0.5	0.7	-0.8	-0.4	-0.8
Falls in the last year	0.4	0.5	0.9	-0.2	1.0	0.7
Arm fat mass (right)	0.4	1.5	3.4	0.0	1.0	1.9
Exposure to tobacco smoke outside home	0.4	0.5	0.9	0.9	0.8	-0.0
Age at first live birth	0.4	0.7	1.6	0.1	-1.3	-0.8
Had major operations	0.4	0.5	1.2	0.0	0.5	1.1
Arm fat percentage (left)	0.4	1.4	2.9	-1.7	-1.1	0.1
Hearing aid user	0.4	0.4	0.7	-0.4	0.8	0.7
Alcohol drinker status: Never	0.4	0.5	1.5	-0.1	0.3	1.2
Ever smoked	0.4	0.7	1.3	0.5	1.2	0.7
Depression (Nagel 2018)	0.3	0.5	1.2	0.0	-0.5	-1.1
Schizophrenia vs Biploar Disorder	0.3	0.4	0.6	0.8	0.6	0.4
Alzheimer’s Disease (in mother)	0.3	0.4	0.7	-0.5	-0.8	-0.4
Alzheimer’s Disease (in father)	0.3	0.3	0.6	-0.0	0.5	0.8
Breast Cancer	0.3	0.7	1.8	0.2	0.4	1.3
Prostate Cancer	0.3	0.4	1.0	-1.0	-0.4	-0.2
HbA1C	0.3	0.3	0.7	0.8	-0.5	-0.3
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.0	-0.3	-0.4	-1.0
Hand grip strength (right)	0.3	0.7	1.0	1.0	0.9	0.6
Maternal smoking around birth	0.3	0.4	0.7	0.7	0.8	0.5
Had other major operations	0.3	0.3	0.5	-0.2	-0.6	-0.7
Financial difficulties in last 2 years	0.3	0.4	0.6	0.4	-0.7	-0.7
Pain all over the body in last month	0.3	0.3	0.9	-0.2	-0.9	-0.2
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.6	0.6	-0.8	-0.5
Alcohol intake versus 10 years previously	0.3	0.4	0.8	0.7	0.9	-0.2
Worrier / anxious feelings	0.3	0.5	0.9	1.0	0.7	0.3
Blood clot in the leg (DVT)	0.3	0.4	0.7	0.3	0.6	0.8
Birth weight	0.3	0.7	1.5	-1.2	-0.2	-0.8
Migraine (self-reported)	0.3	0.4	0.7	0.1	0.6	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.7	-0.8	-0.2	0.4
Diabetes diagnosed by doctor	0.3	0.5	1.0	0.6	0.4	1.0
Arm fat mass (left)	0.3	1.1	2.8	-0.1	0.7	1.7
Eye problems/disorders: Glaucoma	0.3	0.3	0.6	-0.2	-0.6	-0.8
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.6	-0.7	-0.6	0.3
Cholesterol lowering medication	0.3	0.5	1.1	-0.2	-1.1	-0.6
Ovarian Cancer	0.2	0.3	0.5	0.3	0.6	0.7
Lung FEV1/FVC ratio	0.2	1.3	1.8	1.3	1.1	0.9
Chronotype (morning person)	0.2	0.4	1.0	-1.0	0.1	0.1
Angina	0.2	0.2	0.3	-0.5	-0.5	-0.2
Townsend deprivation index at recruitment	0.2	0.3	0.7	-0.8	-0.3	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.5	0.7	0.2	-0.3
Mouth/teeth dental problems	0.2	0.3	0.8	-0.1	-0.5	-0.9
Illnesses of siblings	0.2	0.2	0.5	0.4	0.0	0.7
Arm fat percentage (right)	0.2	0.9	2.1	-1.4	-0.8	0.1
Number of live births	0.2	0.3	0.6	-0.5	-0.1	-0.8
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.7	-0.5	-0.9	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	0.8	-0.8	-0.9	-0.5
Length of working week for main job	0.2	0.2	0.3	-0.5	0.5	-0.2
Glaucoma (self-reported)	0.2	0.2	0.3	0.4	-0.4	-0.5
Forced vital capacity (FVC), Best measure	0.2	0.6	0.8	-0.8	-0.9	-0.6
Health satisfaction	0.2	0.3	0.6	-0.4	0.1	-0.8
Angina (self-reported)	0.2	0.2	0.3	-0.6	-0.6	-0.3
Whole body fat mass	0.2	0.7	1.6	-0.6	0.3	1.2
Leg fat mass (right)	0.2	0.9	1.7	-1.0	0.1	1.3
Family relationship satisfaction	0.2	0.2	0.6	-0.7	-0.0	0.3
Supplements: Vitamin C	0.2	0.3	0.7	0.5	-0.1	0.8
Commuting to job workplace: Walk	0.2	0.2	0.3	-0.5	-0.6	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.3	-0.1	-0.6	-0.5
Osteoarthritis (self-reported)	0.2	0.3	0.5	0.7	-0.3	-0.5
Ever taken oral contraceptive pill	0.2	0.2	0.4	-0.1	0.4	-0.6
Average weekly beer plus cider intake	0.2	0.3	0.8	0.9	0.3	-0.2
Fractured/broken bones in last 5 years	0.2	0.2	0.4	0.3	0.6	0.5
Ever depressed for a whole week	0.2	0.3	0.6	0.8	-0.3	-0.3
Unable to work because of sickness or disability	0.2	0.3	0.6	-0.8	-0.3	0.3
Leg fat mass (left)	0.2	1.0	2.2	-0.6	0.5	1.5
Depressed Affect (Nagel 2018)	0.1	0.2	0.3	-0.3	-0.4	-0.5
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	-0.5	0.1	0.4
Reaction Time	0.1	0.3	0.5	0.3	0.4	0.7
HDL Cholesterol	0.1	0.1	0.2	-0.4	0.3	0.4
Triglycerides	0.1	0.1	0.3	0.1	0.1	-0.6
Blood Eosinophil Count	0.1	0.4	0.7	-0.8	-0.5	0.5
Blood Platelet Count	0.1	1.1	2.2	-0.4	-0.9	-1.5
Hand grip strength (left)	0.1	0.1	0.2	0.5	0.5	0.1
Average weekly fortified wine intake	0.1	0.1	0.1	0.3	0.2	-0.2
Relative age voice broke	0.1	0.2	0.5	0.4	-0.2	-0.7
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	-0.4	-0.2	-0.1
Trunk fat mass	0.1	0.6	1.4	-0.6	0.1	1.2
Past tobacco smoking	0.1	0.2	0.2	0.3	-0.4	-0.5
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	0.4	-0.3	-0.4
Heart attack	0.1	0.1	0.2	-0.2	-0.4	0.4
Medication: Simvastatin	0.1	0.2	0.4	-0.3	-0.6	-0.2
Time employed in main current job	0.1	0.1	0.3	0.3	0.1	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	0.2	0.2	0.5
Mouth/teeth dental problems: Dentures	0.1	0.2	0.7	-0.0	0.1	0.8
Depression (self-reported)	0.1	0.2	0.4	-0.6	-0.2	0.3
Hair/balding pattern: Pattern 4	0.1	0.2	0.4	0.2	-0.6	-0.3
Loud music exposure frequency	0.1	0.1	0.2	0.1	-0.5	-0.4
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.3	0.5	0.1	0.6
Number of full brothers	0.1	0.1	0.3	0.2	0.2	0.5
Number of children fathered	0.1	0.1	0.2	0.3	0.4	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	0.4	-0.3	-0.1
Shortness of breath walking on level ground	0.1	0.2	0.3	0.0	0.5	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.3	0.5	0.1	0.4
Overall health rating	0.1	0.2	0.3	-0.6	-0.3	-0.4
Medication: Aspirin	0.1	0.1	0.2	0.3	-0.4	-0.2
Illnesses of father: Heart disease	0.1	0.1	0.1	0.3	0.2	0.4
Smoking status: Previous	0.1	0.2	0.6	-0.7	-0.2	0.1
Long-standing illness, disability or infirmity	0.1	0.1	0.2	-0.0	0.2	0.5
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.6	-0.1	0.2	-0.8
Medication for cholesterol	0.1	0.2	0.5	0.2	0.7	0.3
Osteoporosis (self-reported)	0.1	0.1	0.1	0.3	0.3	0.3
Miserableness	0.1	0.2	0.3	0.5	0.5	-0.1
High cholesterol (Self-reported)	0.1	0.1	0.1	-0.4	-0.3	0.3
Medication: Atorvastatin	0.1	0.1	0.2	0.4	-0.4	-0.3
Number of operations (self-reported)	0.1	0.1	0.4	-0.2	0.0	0.6
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	-0.1	-0.3	0.5
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.3	0.2	0.4	0.6
Heart disease (siblings)	0.1	0.1	0.3	-0.2	-0.2	-0.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.1	0.0	0.0	-0.3
LDL Cholesterol	0.0	0.1	0.1	-0.3	-0.3	-0.1
Waist Hip Ratio (WHR)	0.0	0.1	0.1	-0.3	-0.4	-0.2
Hair Pigment	0.0	1.1	2.3	1.5	0.9	-0.0
Sensitivity / hurt feelings	0.0	0.1	0.1	0.2	0.4	0.1
Relative age of first facial hair	0.0	0.0	0.1	-0.1	-0.3	-0.1
Diabetes (mother)	0.0	0.1	0.1	0.3	0.2	0.1
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.1	-0.2	-0.3	-0.1
Sitting height	0.0	0.3	0.7	-0.4	-0.8	-0.1
Nervous feelings	0.0	0.1	0.2	-0.1	0.0	0.4
Qualifications: None of the above	0.0	0.0	0.0	0.0	-0.2	0.2
Medication: Cholesterol lowering	0.0	0.1	0.1	0.1	-0.2	0.3
Medication: Lansoprazole	0.0	0.0	0.0	0.0	0.2	0.0
Prospective memory result	0.0	0.0	0.0	-0.1	0.2	0.1
Exposure to tobacco smoke at home	0.0	0.1	0.1	0.3	0.3	0.1
Age at last live birth	0.0	0.0	0.1	0.3	-0.0	-0.3
Leg pain on walking	0.0	0.0	0.0	0.1	-0.1	0.0
Knee pain experienced in last month	0.0	0.1	0.1	-0.2	-0.2	-0.3
Breast cancer (self-reported)	0.0	0.0	0.0	-0.1	0.1	-0.1
Medication: Aspirin	0.0	0.1	0.1	0.4	-0.1	0.2
Number of self-reported non-cancer illnesses	0.0	0.1	0.2	0.5	-0.0	0.1
Mother’s age at death	0.0	0.0	0.1	-0.1	-0.2	-0.3
Pain experienced in last month	0.0	0.1	0.2	-0.4	-0.1	0.3

Hub : Genes

LSM1

Models

Trait associations