TWAS
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Traits
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Traits
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Bipolar Disorder or Schizophrenia
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chr12:1,204,676-2,805,632
Best TWAS P=5.48e-17 · Best GWAS P=3.26e-20 conditioned to 0.000149
1.2M
1.4M
1.6M
1.8M
2M
2.2M
2.4M
2.6M
2.8M
0
5
10
15
20
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Testis
CACNA2D4
0.19
0.04
lasso
5
0.01
9.2e-02
8.9
-8.4
5.5e-17
-0.87
0.04
0.50
TRUE
2
ROSMAP
Brain Pre-frontal Cortex
DCP1B
0.08
0.00
blup
553
0.04
1.8e-05
4.9
-6.0
2.1e-09
-0.30
0.08
0.16
TRUE