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chr12:122,713,991-124,591,385

Best TWAS P=2.75e-10 · Best GWAS P=4.78e-10 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
23	GTEx	Testis	CDK2AP1	0.20	0.14	lasso	5	0.13	2.0e-06	6.1	-6.3	2.7e-10	-0.98	0.01	0.99	TRUE
14	GTEx	Heart Left Ventricle	ABCB9	0.10	0.14	lasso	5	0.10	4.2e-06	6.2	6.2	6.0e-10	1.00	0.01	0.99	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	OGFOD2	0.02	0.00	enet	4	0.02	2.7e-03	5.5	6.1	1.2e-09	0.84	0.01	0.46	FALSE
30	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C12orf65	0.05	0.04	blup	34	0.05	1.0e-03	5.4	-6.1	1.3e-09	-0.97	0.01	0.92	FALSE
42	The Cancer Genome Atlas	Thyroid Carcinoma	PITPNM2	0.04	0.03	enet	5	0.05	8.1e-06	4.3	6.1	1.4e-09	0.75	0.03	0.97	FALSE
32	The Cancer Genome Atlas	Brain Lower Grade Glioma	C12orf65	0.03	0.01	blup	35	0.02	1.6e-03	6.2	-6.0	2.2e-09	-0.91	0.01	0.87	FALSE
28	The Cancer Genome Atlas	Breast Invasive Carcinoma	C12orf65	0.02	0.00	enet	6	0.01	2.4e-03	6.2	-6.0	2.3e-09	-0.86	0.01	0.82	FALSE
18	GTEx	Pancreas	ARL6IP4	0.07	0.07	lasso	2	0.07	9.6e-04	6.2	-5.9	4.4e-09	-0.98	0.03	0.91	FALSE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	ABCB9	0.04	0.05	enet	10	0.05	1.2e-05	5.3	5.9	4.7e-09	0.85	0.00	0.99	FALSE
25	GTEx	Testis	RP11-282O18.3	0.18	0.09	lasso	9	0.12	7.8e-06	6.1	-5.8	5.3e-09	-0.83	0.01	0.96	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	ABCB9	0.13	0.15	lasso	11	0.11	2.1e-06	5.3	5.7	9.0e-09	0.90	0.03	0.97	FALSE
40	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CDK2AP1	0.13	0.10	blup	34	0.11	8.2e-05	6.1	-5.7	1.2e-08	-0.96	0.01	0.97	FALSE
13	GTEx	Heart Left Ventricle	MPHOSPH9	0.06	0.04	lasso	5	0.04	4.2e-03	4.9	5.7	1.5e-08	0.83	0.03	0.91	FALSE
8	GTEx	Cells Transformed fibroblasts	ABCB9	0.08	0.12	enet	7	0.12	4.3e-09	5.3	5.6	1.9e-08	0.85	0.46	0.54	FALSE
17	GTEx	Muscle Skeletal	SETD8	0.16	0.02	lasso	4	0.03	3.8e-04	5.0	5.6	2.1e-08	0.83	0.53	0.36	FALSE
9	GTEx	Cells Transformed fibroblasts	SETD8	0.10	0.12	enet	9	0.09	1.4e-07	5.2	5.6	2.2e-08	0.88	0.11	0.89	FALSE
6	GTEx	Cells Transformed fibroblasts	OGFOD2	0.10	0.07	lasso	7	0.07	3.1e-06	5.6	5.6	2.4e-08	0.89	0.14	0.86	FALSE
24	GTEx	Testis	ABCB9	0.14	0.05	lasso	3	0.06	8.0e-04	3.0	-5.6	2.8e-08	-0.55	0.03	0.88	FALSE
21	GTEx	Skin Sun Exposed Lower leg	ABCB9	0.09	0.08	lasso	5	0.08	4.3e-07	5.3	5.5	3.3e-08	0.88	0.04	0.96	FALSE
34	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ABCB9	0.06	0.06	enet	7	0.07	5.2e-08	5.5	5.5	3.5e-08	0.86	0.00	1.00	FALSE
4	GTEx	Breast Mammary Tissue (Female)	CDK2AP1	0.08	0.03	lasso	3	0.02	6.4e-02	4.8	-5.5	4.2e-08	-0.90	0.05	0.62	FALSE
39	The Cancer Genome Atlas	Prostate Adenocarcinoma	ARL6IP4	0.03	0.04	blup	17	0.04	1.6e-05	5.5	-5.4	5.2e-08	-0.87	0.00	0.99	FALSE
22	GTEx	Testis	MPHOSPH9	0.28	0.27	enet	23	0.32	1.3e-14	4.8	5.4	6.8e-08	0.91	0.06	0.94	FALSE
5	GTEx	Breast Mammary Tissue (Female)	RP11-282O18.3	0.09	0.07	enet	8	0.08	2.8e-03	4.7	-5.4	7.5e-08	-0.90	0.06	0.82	FALSE
7	GTEx	Cells Transformed fibroblasts	C12orf65	0.07	0.05	lasso	4	0.04	5.8e-04	4.5	-5.4	7.6e-08	-0.83	0.03	0.95	FALSE
35	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	OGFOD2	0.02	0.04	lasso	3	0.03	1.3e-04	5.3	5.4	7.9e-08	0.83	0.01	0.96	FALSE
2	GTEx	Artery Tibial	ABCB9	0.04	0.02	lasso	2	0.01	3.0e-02	5.3	5.4	8.7e-08	0.87	0.08	0.87	FALSE
10	GTEx	Colon Sigmoid	ABCB9	0.18	0.16	lasso	6	0.15	4.8e-06	4.7	5.3	1.2e-07	0.88	0.20	0.77	FALSE
11	GTEx	Colon Transverse	ABCB9	0.08	0.07	enet	5	0.09	5.3e-05	4.3	5.3	1.2e-07	0.90	0.06	0.91	FALSE
37	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ABCB9	0.17	0.13	enet	6	0.11	3.9e-05	5.3	5.3	1.2e-07	0.70	0.01	0.98	FALSE
15	GTEx	Liver	ABCB9	0.32	0.32	lasso	3	0.28	1.9e-08	5.3	5.3	1.4e-07	0.83	0.14	0.83	FALSE
36	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CDK2AP1	0.12	0.14	blup	34	0.15	7.2e-07	6.2	-5.3	1.5e-07	-0.89	0.01	0.99	FALSE
29	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ARL6IP4	0.03	0.03	lasso	2	0.02	1.9e-03	5.3	-5.2	1.6e-07	-0.82	0.00	0.94	FALSE
33	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ABCB9	0.19	0.22	enet	9	0.22	7.7e-11	5.3	5.2	1.7e-07	0.84	0.00	1.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	MPHOSPH9	0.05	0.02	bslmm	358	0.02	2.6e-03	5.3	-5.2	1.8e-07	-0.69	0.11	0.78	FALSE
26	NTR	Blood	SBNO1	0.02	0.02	lasso	2	0.02	5.5e-07	5.2	-5.2	2.0e-07	-0.89	0.14	0.85	FALSE
3	GTEx	Brain Cerebellar Hemisphere	PITPNM2	0.19	0.15	lasso	1	0.06	1.1e-02	5.2	-5.2	2.4e-07	-0.86	0.08	0.34	FALSE
27	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	OGFOD2	0.03	0.02	blup	16	0.01	5.0e-02	5.3	5.2	2.4e-07	0.81	0.00	0.88	FALSE
19	GTEx	Pancreas	SETD8	0.20	0.12	lasso	5	0.13	3.4e-06	4.9	-5.2	2.5e-07	-0.89	0.78	0.20	FALSE
16	GTEx	Lung	ABCB9	0.04	0.02	lasso	3	0.02	8.0e-03	4.8	5.1	2.7e-07	0.85	0.06	0.86	FALSE
31	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PITPNM2	0.06	0.07	lasso	5	0.09	1.2e-05	4.8	-5.1	2.9e-07	-0.84	0.05	0.94	FALSE
12	GTEx	Esophagus Muscularis	C12orf65	0.06	0.04	lasso	4	0.04	2.0e-03	5.0	-5.1	3.0e-07	-0.85	0.16	0.78	FALSE