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chr11:65,405,300-67,324,933

Best TWAS P=6.98e-10 · Best GWAS P=2.92e-09 conditioned to 0.744

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	RIN1	0.07	0.04	bslmm	304	0.04	8.7e-06	-3.3	-5.2	2.4e-07	-0.52	0.87	0.07	FALSE
2	GTEx	Adipose Subcutaneous	CTD-3074O7.5	0.11	0.03	lasso	4	0.02	4.2e-03	5.9	6.2	7.0e-10	0.95	0.01	0.97	TRUE
3	GTEx	Artery Tibial	CTD-3074O7.12	0.08	0.01	enet	15	0.03	2.6e-03	4.9	5.3	1.3e-07	0.81	0.05	0.92	FALSE
4	GTEx	Brain Cerebellum	CTD-3074O7.12	0.15	0.12	enet	14	0.08	2.5e-03	-3.7	5.1	2.8e-07	0.61	0.09	0.27	FALSE
5	GTEx	Breast Mammary Tissue	CTD-3074O7.12	0.13	0.05	enet	9	0.05	1.4e-03	-3.6	5.1	3.1e-07	0.62	0.13	0.60	FALSE
6	GTEx	Cells EBV-transformed lymphocytes	CCS	0.21	0.24	enet	11	0.21	2.0e-07	-5.2	5.3	1.3e-07	0.86	0.12	0.87	FALSE
7	GTEx	Esophagus Mucosa	CTD-3074O7.12	0.10	0.04	lasso	7	0.04	1.9e-03	5.9	5.2	2.2e-07	0.89	0.02	0.97	FALSE
8	GTEx	Nerve Tibial	CTSF	0.06	0.01	lasso	3	0.01	7.1e-02	5.8	-5.4	8.7e-08	-0.90	0.01	0.96	FALSE
9	GTEx	Spleen	CCS	0.20	0.19	lasso	4	0.22	3.1e-06	5.9	5.9	2.9e-09	1.00	0.01	0.98	FALSE
10	GTEx	Testis	BBS1	0.07	0.10	lasso	2	0.07	6.3e-04	5.9	-5.8	6.8e-09	-0.96	0.01	0.91	FALSE
11	GTEx	Thyroid	CTSF	0.06	0.01	enet	13	0.03	2.3e-03	5.8	-5.7	1.5e-08	-0.94	0.01	0.98	FALSE
12	GTEx	Thyroid	CTD-3074O7.5	0.37	0.01	lasso	8	0.01	4.6e-02	5.9	5.9	4.0e-09	0.87	0.01	0.98	FALSE
13	GTEx	Thyroid	CTD-3074O7.12	0.11	0.07	lasso	3	0.05	8.6e-05	5.8	5.3	9.9e-08	0.92	0.01	0.99	FALSE
14	METSIM	Adipose	DPP3	0.06	0.04	blup	284	0.04	2.6e-07	-3.7	5.7	1.6e-08	0.74	0.58	0.42	FALSE
15	METSIM	Adipose	RBM14	0.02	0.00	blup	257	0.01	4.8e-02	-2.5	6.0	2.0e-09	0.74	0.04	0.32	FALSE
16	YFS	Blood	CCS	0.17	0.27	lasso	11	0.28	6.6e-94	-5.2	5.3	1.2e-07	0.89	0.13	0.87	FALSE
17	YFS	Blood	LRFN4	0.06	0.05	lasso	5	0.05	7.3e-17	-5.3	5.8	7.6e-09	0.73	0.12	0.88	FALSE
18	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ACTN3	0.09	0.10	lasso	3	0.10	2.7e-11	5.8	-5.6	2.0e-08	-0.96	0.01	0.99	FALSE
19	The Cancer Genome Atlas	Brain Lower Grade Glioma	LRFN4	0.03	0.04	lasso	4	0.03	1.5e-04	-5.3	5.3	1.5e-07	0.60	0.00	0.97	FALSE
20	The Cancer Genome Atlas	Lung Adenocarcinoma	ACTN3	0.07	0.08	blup	39	0.07	4.5e-09	4.8	-5.3	1.3e-07	-0.95	0.01	0.99	FALSE
21	The Cancer Genome Atlas	Lung Adenocarcinoma	BBS1	0.03	0.01	enet	8	0.02	9.9e-04	5.8	5.1	2.8e-07	0.89	0.01	0.96	FALSE
22	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ACTN3	0.05	0.06	blup	39	0.05	3.0e-06	4.9	-5.1	3.0e-07	-0.89	0.03	0.97	FALSE
23	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	BBS1	0.02	0.02	blup	48	0.02	1.3e-03	4.8	5.4	8.3e-08	0.86	0.02	0.87	FALSE
24	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CTSF	0.03	0.03	blup	36	0.04	2.9e-05	5.8	-5.4	5.4e-08	-0.95	0.01	0.99	FALSE
25	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ACTN3	0.18	0.14	lasso	4	0.14	1.8e-06	5.9	-5.7	1.1e-08	-0.96	0.01	0.99	FALSE
26	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SPTBN2	0.11	0.12	lasso	1	0.10	6.3e-05	5.9	-5.9	2.9e-09	-1.00	0.00	0.99	FALSE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	LRFN4	0.02	0.02	blup	25	0.01	3.6e-02	-5.3	5.3	1.1e-07	0.68	0.00	0.89	FALSE
28	The Cancer Genome Atlas	Soft Tissue Sarcoma	ACTN3	0.08	0.06	blup	38	0.07	9.2e-05	5.8	-5.5	3.7e-08	-0.91	0.01	0.97	FALSE
29	The Cancer Genome Atlas	Thyroid Carcinoma	LRFN4	0.03	0.04	lasso	2	0.04	2.2e-04	-5.3	5.3	1.3e-07	0.61	0.00	0.96	FALSE