Hub : Genes

DCP1B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Breast Mammary Tissue (Female) 0.0617 0.1054 0.33000 -0.009 NA -0.009 NA -0.009 0.82 NA 0.71 NA 0.71
2 ROSMAP Brain Pre-frontal Cortex 0.0848 0.0258 0.00023 -0.002 0.036 0.000 0.035 -0.002 0.87 1.8e-05 0.35 2.3e-05 0.99
3 TCGA Ovarian Serous Cystadenocarcinoma 0.0610 0.0300 0.00970 -0.004 0.009 0.003 NA -0.001 0.99 7.3e-02 0.20 NA 0.42

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 2.2 3.4 10.1 0.0 -3.2 0.3
Bipolar Disorder or Schizophrenia 5.5 13.3 35.9 0.0 -6.0 2.0
Depressed Affect (Nagel 2018) 0.2 0.4 1.0 0.0 -0.3 1.0
Depression (Nagel 2018) 0.2 0.2 0.5 0.0 -0.7 0.4
Intelligence (Savage-Jansen 2018) 1.1 3.5 7.1 0.0 1.8 2.7
Neuroticism (Nagel 2018) 0.7 1.5 3.5 0.0 -1.9 1.1
Schizophrenia (2018) 5.3 10.9 27.3 0.0 -5.2 2.3
Schizophrenia vs Biploar Disorder 0.8 1.1 2.8 0.0 -1.7 0.6
Worry (Nagel 2018) 1.7 3.6 8.0 0.0 -2.8 1.7
Alzheimer’s Disease (in mother) 0.2 0.2 0.5 0.0 -0.3 -0.7
Alzheimer’s Disease (in father) 1.0 1.1 2.5 0.0 -0.8 -1.6
Alzheimer’s Disease (including proxy) 1.4 2.0 5.5 0.0 -0.6 -2.4
Crohns Disease (2017) 1.0 2.3 4.1 0.0 -1.6 2.0
Irritable Bowel Disease (IBD) 0.9 2.1 3.6 0.0 -1.9 1.7
Ulcerative Colitis (UC) 0.4 0.8 2.1 0.0 -1.5 0.6
Major Depression (MDD) 0.5 0.6 1.5 0.0 -0.5 1.2
Reaction Time 0.2 0.4 1.1 0.0 -1.1 0.2
Verbal and Numeric Reasoning (VNR) 1.7 4.2 9.8 0.0 1.6 3.1
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 0.2 0.2 0.6 0.0 -0.7 0.3
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.3 0.4 1.2 0.0 1.1 0.3
Bipolar Disorder (2011) 0.3 0.3 0.9 0.0 -0.1 0.9
Body Mass Index (BMI) (2010) 0.1 0.1 0.3 0.0 0.1 0.5
Coronary Artery Disease (CAD) 3.4 4.1 8.9 0.0 -3.0 1.8
Crohns Disease (2012) 0.1 0.1 0.3 0.0 0.3 0.6
Mean Putamen Volume 1.8 2.1 5.9 0.0 2.4 -0.6
Fasting Glucose 1.2 1.4 2.4 0.0 -1.3 -1.6
HbA1C 0.9 1.0 2.6 0.0 1.6 -0.7
HDL Cholesterol 0.0 0.1 0.2 0.0 0.4 0.1
LDL Cholesterol 0.1 0.1 0.3 0.0 -0.5 0.3
Lupus 0.4 0.6 1.4 0.0 -0.6 -1.2
Neuroticism (2016) 0.4 0.6 1.3 0.0 -1.2 0.7
Primary Biliary Cirrhosis 0.6 0.8 2.3 0.0 -0.3 1.5
Rheumatoid Arthritis 0.1 0.1 0.3 0.0 0.5 0.3
Schizophrenia (2014) 5.4 11.9 30.9 0.0 -5.6 2.2
Triglycerides 0.0 0.1 0.1 0.0 -0.3 -0.3
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.5 0.0 1.2 -0.6
Ulcerative Colitis 0.2 0.3 1.0 0.0 -1.0 0.0
Blood Eosinophil Count 0.0 0.3 0.7 0.0 0.4 -0.8
Blood Platelet Count 0.3 3.6 10.8 0.0 3.3 0.2
Blood Red Count 0.2 1.6 4.5 0.0 -2.1 0.4
Blood White Count 0.1 0.4 1.3 0.0 1.1 0.0
Heel T-Score 0.1 0.8 2.5 0.0 1.6 0.0
BMI 0.0 0.1 0.3 0.0 0.2 -0.6
Height 0.1 2.2 4.5 0.0 2.1 -1.4
Waist Hip Ratio (WHR) 0.3 1.4 2.6 0.0 1.6 -1.2
Systolic Blood Pressure 0.4 1.9 3.3 0.0 -1.8 -1.5
Smoking Status 0.2 0.5 1.3 0.0 -1.1 -0.5
Allergy or Eczema 0.3 0.7 1.8 0.0 0.5 1.4
Cardiovascular Disease 1.2 3.9 10.8 0.0 -3.3 0.9
Hypothyroidism (self reported) 0.3 0.7 1.7 0.0 -1.3 -0.5
Respiratory disease 0.0 0.0 0.0 0.0 0.1 0.1
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.5 0.0 0.4 0.7
Lung FEV1/FVC ratio 0.0 0.1 0.3 0.0 0.5 0.2
Lung FVC 0.0 0.1 0.2 0.0 -0.5 0.3
Neuroticism 0.6 1.5 2.8 0.0 -1.7 1.3
Chronotype (morning person) 1.6 3.8 9.6 0.0 3.1 -1.3
Hair Pigment 0.0 0.5 1.6 0.0 1.2 -0.0
Tanning 0.1 0.6 1.1 0.0 0.9 -1.1
Hand grip strength (left) 0.1 0.2 0.4 0.0 0.6 -0.4
Number of treatments/medications taken 0.1 0.2 0.6 0.0 0.3 -0.8
Average weekly spirits intake 0.0 0.1 0.2 0.0 0.2 0.4
Sensitivity / hurt feelings 0.4 0.6 1.8 0.0 -1.3 0.3
Frequency of depressed mood in last 2 weeks 0.6 0.9 1.7 0.0 -1.3 1.0
Hearing difficulty/problems: Yes 0.2 0.2 0.6 0.0 -0.8 -0.3
Relative age of first facial hair 1.2 2.5 7.2 0.0 2.7 -0.6
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 0.7 0.0 -0.3 -0.8
Ever used hormone-replacement therapy (HRT) 0.0 0.0 0.0 0.0 0.2 0.1
Ever had hysterectomy (womb removed) 0.4 0.4 1.2 0.0 1.1 0.2
Systolic blood pressure, automated reading 0.4 1.3 2.7 0.0 -1.1 -1.6
Eye problems/disorders: Diabetes related eye disease 1.3 1.5 2.8 0.0 1.7 1.3
Angina 0.5 0.6 1.8 0.0 -1.4 -0.1
Medication for hormone replacement therapy 1.3 1.4 4.0 0.0 -2.0 0.5
Vitamin and mineral supplements 0.4 0.5 1.5 0.0 1.2 -0.2
Supplements: Zinc 0.4 0.5 1.0 0.0 -0.6 1.0
Medication: Co-codamol 0.4 0.5 1.2 0.0 0.5 1.1
Medication: Metformin 0.7 0.9 2.3 0.0 1.5 0.7
Diabetes (father) 0.6 0.8 1.9 0.0 -0.6 1.4
Diabetes (mother) 0.5 0.7 1.7 0.0 1.3 -0.6
Severe depression (siblings) 0.3 0.4 1.2 0.0 1.1 -0.1
Pack years adult smoking proportion 1.0 1.5 4.3 0.0 2.1 -0.2
Impedance of leg (right) 0.1 0.5 1.4 0.0 -1.2 -0.1
Leg fat-free mass (left) 0.1 0.3 0.9 0.0 0.9 0.2
Trunk fat percentage 0.0 0.1 0.4 0.0 0.0 -0.6
Hand grip strength (right) 0.1 0.2 0.5 0.0 0.3 -0.7
Townsend deprivation index at recruitment 0.2 0.2 0.6 0.0 0.2 -0.8
Current tobacco smoking 0.2 0.4 0.8 0.0 0.6 -0.9
Average weekly fortified wine intake 0.6 0.7 1.1 0.0 1.1 1.0
Maternal smoking around birth 0.1 0.1 0.2 0.0 0.3 0.4
Fed-up feelings 0.2 0.4 1.2 0.0 1.1 0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.6 0.0 0.5 -0.8
Relative age voice broke 0.1 0.2 0.3 0.0 0.4 0.6
Taking other prescription medications 0.1 0.1 0.3 0.0 0.6 0.0
Age when periods started (menarche) 0.2 0.5 1.4 0.0 1.2 -0.4
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 1.8 0.0 1.4 0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.6 1.1 0.0 0.9 1.1
Tinnitus: Yes, but not now, but have in the past 0.8 0.8 2.0 0.0 -1.4 0.7
Qualifications: CSEs or equivalent 0.1 0.2 0.5 0.0 -0.1 0.7
Serious illness, injury or assault to yourself 1.7 2.0 6.1 0.0 -2.5 -0.1
High blood pressure 0.5 1.4 3.7 0.0 -1.9 0.6
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.1 0.0 0.9 1.0
Multivitamins +/- minerals 1.2 1.5 4.5 0.0 -2.1 0.2
Stomach or abdominal pain in last month 0.8 1.0 2.9 0.0 1.7 -0.5
Supplements: Glucosamine 0.3 0.4 0.9 0.0 0.9 -0.7
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.6 0.0 0.5 -1.3
Medication: Atenolol 0.3 0.4 1.0 0.0 -1.0 0.3
Medication: Levothyroxine sodium 0.1 0.2 0.5 0.0 -0.7 0.1
Sitting height 0.0 0.3 0.7 0.0 0.5 -0.9
Chronic bronchitis/emphysema (father) 0.3 0.4 0.6 0.0 0.7 0.7
High blood pressure (mother) 1.2 1.6 4.6 0.0 -0.5 2.2
Body mass index (BMI) 0.0 0.2 0.5 0.0 0.7 -0.1
Impedance of leg (left) 0.1 0.5 1.3 0.0 -1.1 -0.3
Leg predicted mass (left) 0.1 0.3 0.8 0.0 0.9 0.2
Trunk fat mass 0.1 0.3 0.8 0.0 0.4 -0.9
Waist circumference 0.1 0.3 0.6 0.0 0.8 -0.5
Number of incorrect matches in round 0.8 1.4 3.2 0.0 -1.8 -1.0
Past tobacco smoking 0.2 0.4 0.8 0.0 0.5 0.9
Alcohol usually taken with meals 0.8 1.3 2.3 0.0 1.3 1.5
Nervous feelings 1.4 2.5 5.4 0.0 -2.3 1.5
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 1.5 0.0 -1.2 -1.1
Hearing difficulty/problems with background noise 0.4 0.7 1.9 0.0 -1.4 -0.3
Hair/balding pattern: Pattern 2 1.2 1.5 2.5 0.0 1.4 1.6
Had menopause 0.7 0.8 2.3 0.0 1.5 -0.5
Had other major operations 0.8 0.9 2.3 0.0 1.5 0.6
Forced vital capacity (FVC) 0.1 0.2 0.6 0.0 -0.8 -0.2
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.2 0.4 0.0 0.6 0.5
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 0.6 0.0 -0.2 0.8
Qualifications: None of the above 0.4 0.8 1.7 0.0 -1.3 -0.9
Financial difficulties in last 2 years 0.0 0.0 0.0 0.0 0.0 0.2
Mouth/teeth dental problems 0.0 0.1 0.2 0.0 0.4 0.2
Heart attack 0.3 0.4 0.6 0.0 -0.7 0.8
Allergy 0.4 1.0 1.7 0.0 -1.1 -1.3
Pain all over the body in last month 0.1 0.1 0.2 0.0 -0.4 -0.4
Diabetes (self-reported) 0.9 1.4 3.1 0.0 1.8 1.1
Hayfever/allergic rhinitis (self-reported) 0.0 0.1 0.1 0.0 0.3 -0.3
Medication: Ramipril 0.2 0.2 0.7 0.0 -0.8 -0.1
Medication: Simvastatin 0.3 0.5 1.1 0.0 0.6 -1.0
Fluid intelligence score 1.4 2.8 4.3 0.0 2.0 2.1
Illnesses of siblings 1.4 1.9 3.0 0.0 1.6 1.7
Neuroticism score 0.4 0.8 1.9 0.0 -1.4 0.7
Weight 0.1 0.3 0.6 0.0 0.8 -0.6
Impedance of arm (right) 0.0 0.2 0.4 0.0 -0.6 0.4
Arm fat percentage (right) 0.0 0.1 0.3 0.0 0.5 -0.3
Trunk fat-free mass 0.1 0.6 1.0 0.0 1.0 -0.9
Hip circumference 0.1 0.3 0.8 0.0 -0.9 -0.2
Time employed in main current job 0.1 0.1 0.3 0.0 0.5 -0.2
Alcohol intake versus 10 years previously 0.8 1.2 3.3 0.0 0.6 -1.8
Father’s age at death 0.1 0.1 0.3 0.0 -0.2 0.6
Worrier / anxious feelings 0.9 1.7 4.8 0.0 -2.2 0.4
Frequency of tiredness / lethargy in last 2 weeks 1.2 1.9 3.9 0.0 -1.4 -2.0
Falls in the last year 1.2 1.6 3.5 0.0 1.1 -1.9
Hair/balding pattern: Pattern 3 0.4 0.5 0.9 0.0 -1.0 -0.8
Number of live births 1.5 2.1 4.4 0.0 2.1 -1.4
Forced expiratory volume in 1-second (FEV1) 0.1 0.5 1.3 0.0 -1.1 -0.3
Pulse rate 2.2 3.7 7.3 0.0 2.7 -1.9
Happiness 0.3 0.3 0.6 0.0 0.8 -0.6
Noisy workplace 0.1 0.2 0.5 0.0 -0.1 -0.7
Qualifications: A levels/AS levels or equivalent 0.2 0.3 0.6 0.0 -0.7 0.8
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.2 0.4 0.0 0.6 0.3
Mouth/teeth dental problems: Dentures 0.5 0.8 2.5 0.0 1.6 0.1
Asthma 0.2 0.3 0.7 0.0 0.5 0.9
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.1 3.3 0.0 -0.1 -1.8
Medication: Cholesterol lowering 0.2 0.3 0.9 0.0 0.4 0.9
Depression (self-reported) 2.4 2.9 5.0 0.0 -1.9 2.2
Medication: Lansoprazole 1.7 2.0 5.8 0.0 0.4 -2.4
Prospective memory result 0.2 0.3 0.8 0.0 -0.9 0.4
Lung cancer (father) 0.1 0.1 0.3 0.0 0.5 -0.2
Illnesses of mother 0.4 0.5 1.6 0.0 0.1 1.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.2 0.3 0.0 -0.6 0.4
Pulse wave Arterial Stiffness index 0.7 0.8 1.7 0.0 0.8 1.3
Impedance of arm (left) 0.1 0.3 0.8 0.0 -0.9 0.4
Arm fat mass (right) 0.0 0.1 0.3 0.0 0.6 -0.1
Trunk predicted mass 0.1 0.5 1.1 0.0 1.0 -0.7
Standing height 0.1 0.6 1.6 0.0 0.4 -1.3
Length of working week for main job 1.3 1.4 3.5 0.0 -1.9 0.9
Exposure to tobacco smoke at home 1.5 1.7 3.5 0.0 -1.3 1.9
Breastfed as a baby 1.1 1.3 3.6 0.0 0.6 -1.9
Tense / ‘highly strung’ 1.2 2.0 5.3 0.0 -2.3 -0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.0 2.4 0.0 -1.6 0.7
Hair/balding pattern: Pattern 4 0.6 1.4 3.4 0.0 -0.8 -1.9
Birth weight of first child 0.6 1.1 1.9 0.0 1.4 -1.2
Peak expiratory flow (PEF) 0.1 0.3 0.5 0.0 -0.6 -0.7
Pulse wave reflection index 0.4 0.5 1.0 0.0 -0.8 1.0
Ever highly irritable/argumentative for 2 days 0.3 0.4 0.8 0.0 0.6 -0.9
Loud music exposure frequency 0.1 0.1 0.1 0.0 -0.3 -0.3
Qualifications: O levels/GCSEs or equivalent 1.5 2.5 6.2 0.0 1.1 2.5
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 2.0 0.0 -1.4 0.7
Blood clot in the leg (DVT) 0.1 0.1 0.2 0.0 0.2 0.4
Medication: Paracetamol 0.6 0.9 2.8 0.0 -1.7 0.1
Headache pain in last month 0.2 0.4 0.9 0.0 0.6 -0.9
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.5 0.0 0.7 -0.3
Glaucoma (self-reported) 0.2 0.3 0.4 0.0 -0.6 -0.6
Gout (self-reported) 0.6 0.8 1.3 0.0 -1.1 -1.0
Hypothyroidism/myxoedema (self-reported) 0.6 1.1 2.9 0.0 -1.7 0.7
Medication: Amlodipine 0.6 0.8 2.4 0.0 -1.6 0.3
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.5 0.0 -0.1 1.2
Birth weight 1.5 3.3 9.9 0.0 0.2 -3.1
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.1 0.0 1.0 -1.0
High blood pressure (siblings) 0.9 1.4 2.1 0.0 -1.4 -1.4
Forced vital capacity (FVC), Best measure 0.0 0.0 0.1 0.0 -0.2 0.3
Body fat percentage 0.1 0.2 0.5 0.0 0.4 -0.7
Leg fat percentage (right) 0.1 0.2 0.3 0.0 0.6 -0.5
Arm fat-free mass (right) 0.1 0.4 0.7 0.0 0.7 -0.8
Exposure to tobacco smoke outside home 0.0 0.0 0.1 0.0 -0.0 0.4
Comparative body size at age 10 0.4 1.2 3.0 0.0 -0.7 -1.7
Number of full brothers 0.2 0.3 0.6 0.0 0.6 0.8
Worry too long after embarrassment 1.5 2.5 7.5 0.0 -2.7 0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.6 2.0 3.1 0.0 -1.7 1.8
Wheeze or whistling in the chest in last year 1.0 1.8 2.8 0.0 1.7 -1.7
Number of children fathered 0.0 0.0 0.1 0.0 -0.0 0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.0 0.0 0.1 0.0 -0.3 0.2
Age at first live birth 0.2 0.4 0.8 0.0 -0.6 0.9
Pulse wave peak to peak time 0.8 0.9 2.1 0.0 -0.8 -1.4
Health satisfaction 0.6 0.8 2.4 0.0 0.2 -1.6
Shortness of breath walking on level ground 0.5 0.6 1.7 0.0 0.2 -1.3
Qualifications: College or University degree 0.9 2.9 8.7 0.0 -0.3 3.0
Eye problems/disorders: None of the above 0.0 0.1 0.1 0.0 0.4 -0.2
Mouth/teeth dental problems: Loose teeth 0.3 0.3 1.0 0.0 -1.0 -0.2
Emphysema/chronic bronchitis 0.1 0.1 0.3 0.0 -0.1 0.6
Medication for pain relief, constipation, heartburn 0.3 0.6 1.5 0.0 0.5 1.2
Neck or shoulder pain in last month 0.6 0.9 1.7 0.0 -1.0 -1.3
Medication: Blood pressure 0.3 0.6 1.8 0.0 -1.4 0.1
Angina (self-reported) 0.3 0.4 1.3 0.0 -1.1 -0.0
Migraine (self-reported) 1.1 1.3 3.5 0.0 0.7 -1.9
Medication: Ibuprofen 0.6 0.7 1.2 0.0 -1.0 -1.1
Medication: Allopurinol 0.8 1.1 1.7 0.0 -1.2 -1.3
Medication: Omeprazole 0.0 0.0 0.0 0.0 0.1 -0.1
Medication: Seretide 50 evohaler 0.4 0.5 1.0 0.0 -0.6 -1.0
Mean time to correctly identify matches 0.0 0.1 0.1 0.0 -0.2 -0.4
Heart disease (mother) 0.3 0.4 1.2 0.0 -1.1 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 3.2 0.0 -0.8 1.8
Whole body fat mass 0.1 0.3 0.6 0.0 0.5 -0.8
Leg fat mass (right) 0.0 0.2 0.3 0.0 0.6 -0.5
Arm predicted mass (right) 0.0 0.2 0.5 0.0 0.7 -0.5
Pulse rate, automated reading 1.4 4.4 6.8 0.0 2.5 -2.6
Alcohol intake frequency. 0.3 0.7 2.2 0.0 1.5 0.1
Comparative height size at age 10 0.1 0.6 1.2 0.0 -0.7 -1.1
Number of full sisters 0.1 0.2 0.3 0.0 -0.5 0.5
Suffer from ‘nerves’ 0.5 0.8 2.0 0.0 -0.6 1.4
Overall health rating 1.1 2.4 7.1 0.0 -0.0 -2.7
Chest pain or discomfort 0.1 0.2 0.6 0.0 0.0 -0.8
Had major operations 0.6 0.7 1.2 0.0 -0.9 1.1
Age at last live birth 0.3 0.5 1.5 0.0 -0.2 1.2
Family relationship satisfaction 1.5 1.9 4.7 0.0 1.0 -2.2
Leg pain on walking 1.7 2.1 6.3 0.0 -0.3 -2.5
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.3 0.0 1.1 -0.3
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.2 0.0 0.5 -0.1
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 3.1 0.0 1.7 -0.1
Medication: Aspirin 0.0 0.0 0.0 0.0 0.2 0.1
Supplements: Vitamin C 1.6 1.9 3.6 0.0 -1.9 1.4
Knee pain experienced in last month 0.1 0.1 0.1 0.0 0.3 -0.4
Hypertension (Self-reported) 0.7 1.9 5.3 0.0 -2.3 0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.2 0.0 0.1 -0.5
Illnesses of father: Heart disease 0.2 0.3 0.8 0.0 -0.4 0.9
Illnesses of siblings: Diabetes 0.2 0.3 0.6 0.0 -0.8 -0.5
Smoking status: Previous 0.0 0.0 0.1 0.0 0.2 -0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 1.2 0.0 0.5 -1.1
Whole body fat-free mass 0.1 0.4 1.0 0.0 1.0 -0.4
Leg fat-free mass (right) 0.0 0.2 0.6 0.0 0.8 0.0
Arm fat percentage (left) 0.0 0.1 0.2 0.0 0.5 -0.3
Average weekly red wine intake 0.2 0.3 0.8 0.0 -0.4 0.9
Handedness (chirality/laterality): Left-handed 1.1 1.3 2.4 0.0 1.2 -1.5
Mood swings 0.0 0.1 0.2 0.0 -0.5 0.0
Loneliness, isolation 0.1 0.1 0.3 0.0 -0.6 0.1
Long-standing illness, disability or infirmity 0.7 1.1 2.0 0.0 1.1 -1.4
Ever had bowel cancer screening 0.8 0.9 1.5 0.0 -1.2 1.2
Diabetes diagnosed by doctor 0.9 1.5 3.1 0.0 1.7 1.1
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.4 0.0 0.6 -0.2
Friendships satisfaction 0.2 0.3 0.8 0.0 0.9 0.0
Qualifications: nursing, teaching 0.9 1.4 3.0 0.0 1.1 1.7
Commuting to job workplace: Walk 0.1 0.1 0.2 0.0 -0.2 -0.5
Eye problems/disorders: Cataract 1.7 1.9 5.2 0.0 -2.3 -0.8
Mouth/teeth dental problems: Mouth ulcers 0.0 0.0 0.1 0.0 -0.4 -0.1
Medication for cholesterol 0.0 0.1 0.1 0.0 -0.4 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.0 2.5 0.0 -1.6 0.7
Back pain experienced in last month 0.2 0.2 0.7 0.0 -0.9 0.1
Mineral and other dietary supplements 0.1 0.1 0.3 0.0 0.3 0.6
Breast cancer (self-reported) 0.2 0.3 0.6 0.0 0.5 0.8
Asthma (self-reported) 0.1 0.2 0.4 0.0 0.4 0.7
Osteoporosis (self-reported) 0.3 0.3 0.9 0.0 -0.9 0.3
Osteoarthritis (self-reported) 0.3 0.4 0.9 0.0 1.0 -0.5
Medication: Aspirin 0.0 0.0 0.0 0.0 -0.0 -0.2
Medication: Gliclazide 0.6 0.6 1.4 0.0 1.2 -0.7
Illnesses of father: None of the above (group 1) 0.7 0.9 2.6 0.0 1.6 -0.2
Smoking status: Current 0.2 0.3 0.9 0.0 -0.2 -0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.3 0.7 0.0 -0.8 0.6
Whole body water mass 0.1 0.4 1.0 0.0 1.0 -0.3
Leg predicted mass (right) 0.0 0.2 0.7 0.0 0.9 0.1
Arm fat mass (left) 0.0 0.1 0.3 0.0 0.5 -0.4
Number of self-reported non-cancer illnesses 0.2 0.4 1.1 0.0 -1.0 0.3
Average weekly champagne plus white wine intake 0.0 0.0 0.1 0.0 -0.2 0.2
Miserableness 0.1 0.1 0.4 0.0 0.6 -0.2
Guilty feelings 0.2 0.3 0.7 0.0 -0.3 0.8
Wears glasses or contact lenses 0.1 0.1 0.4 0.0 0.2 -0.6
Ever taken oral contraceptive pill 0.1 0.1 0.2 0.0 0.2 -0.4
Hearing aid user 0.8 0.9 2.0 0.0 1.4 -0.8
Mother’s age at death 0.1 0.2 0.3 0.0 -0.5 -0.6
Financial situation satisfaction 0.4 0.5 1.6 0.0 1.2 0.3
Tinnitus: Yes, now most or all of the time 0.6 0.8 2.2 0.0 -0.2 -1.5
Commuting to job workplace: Public transport 0.5 0.6 1.0 0.0 1.0 -1.0
Eye problems/disorders: Glaucoma 0.1 0.1 0.3 0.0 0.1 -0.6
Medication: Blood pressure 0.0 0.1 0.1 0.0 0.4 -0.3
Pain type(s) experienced in last month: Hip pain 0.0 0.0 0.0 0.0 0.1 -0.1
Supplements: Fish oil (including cod liver oil) 0.1 0.2 0.5 0.0 -0.7 -0.0
High cholesterol (Self-reported) 0.2 0.4 1.1 0.0 -0.3 1.1
Medication: Bendroflumethiazide 0.1 0.1 0.2 0.0 0.4 -0.5
Medication: Paracetamol 1.3 2.0 5.7 0.0 -2.4 0.5
Medication: Lisinopril 0.4 0.5 1.0 0.0 -1.0 -0.6
Medication: Atorvastatin 1.1 1.4 4.0 0.0 0.1 2.0
Illnesses of father: High blood pressure 2.0 2.5 7.5 0.0 -2.7 -0.3
Alcohol drinker status: Never 0.4 0.5 1.4 0.0 0.1 1.2
Ever smoked 0.5 0.8 2.4 0.0 -0.4 -1.6
Basal metabolic rate 0.1 0.3 0.8 0.0 0.9 -0.3
Leg fat percentage (left) 0.1 0.3 0.6 0.0 0.5 -0.8
Arm fat-free mass (left) 0.1 0.3 0.5 0.0 0.7 -0.7
Number of operations (self-reported) 1.1 1.6 4.9 0.0 0.1 2.2
Average weekly beer plus cider intake 1.0 1.4 3.3 0.0 -0.9 -1.8
Irritability 0.4 0.7 1.6 0.0 -1.3 -0.6
Risk taking 1.1 1.7 4.7 0.0 -2.2 -0.6
Ever had prostate specific antigen (PSA) test 0.3 0.3 0.6 0.0 -0.6 -0.8
Fractured/broken bones in last 5 years 2.1 2.7 7.8 0.0 -2.8 -0.4
Age started oral contraceptive pill 0.2 0.3 0.9 0.0 0.2 -0.9
Diastolic blood pressure, automated reading 0.5 1.6 2.9 0.0 -1.4 -1.7
Ever depressed for a whole week 1.3 1.6 3.1 0.0 -1.8 1.3
Unable to work because of sickness or disability 1.0 1.3 2.5 0.0 1.2 -1.6
Commuting to job workplace: Cycle 0.0 0.1 0.1 0.0 -0.3 0.3
Myopia 0.3 0.4 1.0 0.0 -0.4 -1.0
Vascular/heart problems diagnosed by doctor 0.5 1.4 4.1 0.0 2.0 -0.5
Cholesterol lowering medication 0.4 0.6 1.2 0.0 0.8 1.1
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.3 0.0 0.2 -0.5
Pain experienced in last month 1.0 1.6 4.9 0.0 0.1 2.2
Supplements: Calcium 0.4 0.4 0.9 0.0 -1.0 0.6
Basal cell carcinoma (self-reported) 0.0 0.0 0.0 0.0 0.0 -0.1
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.5 0.0 -0.7 0.5
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.2 0.0 0.3 0.4
Heart disease (siblings) 0.3 0.3 0.6 0.0 -0.7 -0.7
Alcohol drinker status: Previous 1.3 1.5 3.8 0.0 2.0 -0.8
Pack years of smoking 1.1 1.7 4.8 0.0 2.2 -0.4
Impedance of whole body 0.1 0.6 1.7 0.0 -1.3 -0.1
Leg fat mass (left) 0.0 0.2 0.3 0.0 0.5 -0.5
Arm predicted mass (left) 0.1 0.3 0.5 0.0 0.7 -0.7