Hub : Genes

CACNA2D4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.1400 0.0440 1.1e-03 0.048 NA 0.076 NA 0.092 8.7e-05 NA 8.7e-07 NA 6.0e-08
2 GTEx Brain Caudate basal ganglia 0.4500 0.1010 3.6e-05 0.187 NA 0.174 NA 0.168 4.8e-06 NA 1.0e-05 NA 1.5e-05
3 GTEx Breast Mammary Tissue (Female) 0.1145 0.0740 1.0e-01 0.007 NA -0.010 NA -0.010 1.9e-01 NA 9.0e-01 NA 8.5e-01
4 GTEx Colon Sigmoid 0.3590 0.0980 1.4e-03 0.111 NA 0.075 NA 0.108 9.9e-05 NA 1.3e-03 NA 1.2e-04
5 GTEx Nerve Tibial 0.3581 0.0563 1.0e-12 0.200 NA 0.232 NA 0.262 3.6e-14 NA 2.0e-16 NA 1.1e-18
6 GTEx Testis 0.1930 0.0760 7.3e-03 0.042 NA -0.004 NA 0.012 6.1e-03 NA 5.8e-01 NA 9.2e-02
7 GTEx Thyroid 0.1720 0.0510 3.3e-04 0.063 NA 0.065 NA 0.070 1.4e-05 NA 1.0e-05 NA 4.7e-06
8 METSIM Adipose 0.0657 0.0251 3.2e-03 -0.001 0.016 0.007 0.017 0.005 4.3e-01 0.00140 2.4e-02 0.0012 5.8e-02
9 TCGA Prostate Adenocarcinoma 0.0541 0.0264 8.6e-03 0.008 0.028 0.010 NA 0.022 4.4e-02 0.00060 2.5e-02 NA 2.3e-03
10 TCGA Thyroid Carcinoma 0.0810 0.0330 5.0e-04 0.053 0.030 0.027 NA 0.044 7.0e-06 0.00058 1.1e-03 NA 3.6e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 3.7 5.9 31.5 -1.3 -0.5 -0.8 -0.7 -0.5 -5.6 -0.5 4.5 -0.7 -1.8
Bipolar Disorder or Schizophrenia 5.5 13.3 70.2 -2.4 -1.4 -2.6 -1.8 -1.7 -8.4 -1.6 5.0 -1.4 -3.5
Depressed Affect (Nagel 2018) 0.6 1.2 3.0 -1.2 -0.3 -1.3 -1.3 -1.7 0.1 -1.7 -0.1 -0.4 -0.8
Depression (Nagel 2018) 1.4 2.0 6.4 -2.5 -1.0 -1.8 -1.8 -1.6 -0.3 -1.4 0.3 -1.2 -0.4
Intelligence (Savage-Jansen 2018) 0.2 0.6 1.8 0.6 1.2 0.8 0.2 0.1 1.3 0.1 -1.2 -0.0 0.6
Neuroticism (Nagel 2018) 1.8 4.1 8.2 -2.0 -1.6 -2.6 -2.5 -2.9 -2.5 -2.5 0.4 -1.1 -0.5
Schizophrenia (2018) 3.8 7.9 38.7 -2.0 -1.4 -2.7 -1.8 -1.8 -6.2 -1.6 2.7 -1.2 -3.1
Schizophrenia vs Biploar Disorder 0.5 0.7 2.8 -1.2 -0.8 -1.7 -0.6 -1.1 -0.0 -0.6 -0.1 -0.6 -0.1
Worry (Nagel 2018) 1.7 3.6 15.1 -1.2 -1.3 -2.2 -1.8 -2.1 -3.9 -2.0 0.5 -0.9 -0.1
Alzheimer’s Disease (in mother) 0.4 0.5 1.2 -0.2 -0.5 -1.1 -0.6 -0.8 -0.9 -0.3 0.8 0.3 -0.6
Alzheimer’s Disease (in father) 1.1 1.2 2.4 -1.0 -1.3 -1.4 -1.1 -1.2 0.1 -1.1 1.6 0.5 0.7
Alzheimer’s Disease (including proxy) 1.4 2.0 3.9 -1.1 -1.4 -2.0 -1.6 -2.0 -1.0 -1.9 1.0 0.3 -1.1
Crohns Disease (2017) 0.2 0.4 1.2 -1.0 -0.4 -0.9 -0.3 -0.6 -0.3 -0.0 0.5 -1.1 0.1
Irritable Bowel Disease (IBD) 0.1 0.3 0.6 -0.3 0.6 -0.3 0.5 0.3 -0.7 0.5 0.8 -0.8 0.1
Ulcerative Colitis (UC) 0.4 0.7 2.1 0.7 1.5 0.4 1.0 1.0 -0.9 0.8 0.7 -0.1 0.2
Major Depression (MDD) 0.5 0.6 1.6 -1.0 -0.6 -1.2 -0.6 -0.9 -0.9 -0.3 -0.6 -0.1 -0.3
Reaction Time 0.2 0.3 1.0 0.4 0.3 0.2 0.3 -0.2 0.6 0.5 -0.7 -1.0 0.6
Verbal and Numeric Reasoning (VNR) 0.4 0.9 2.4 0.9 1.6 0.7 0.6 0.5 0.3 0.5 -1.4 0.9 1.2
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 1.1 1.5 2.9 -1.0 -1.1 -1.5 -1.7 -1.6 -0.8 -1.4 -1.3 -1.0 0.5
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.4 0.6 2.1 0.4 0.6 1.2 0.3 0.5 -1.3 0.1 -1.4 0.1 0.4
Bipolar Disorder (2011) 2.3 2.3 17.7 -0.7 0.0 0.2 0.0 -0.1 -4.2 -0.5 1.5 -1.1 -0.9
Body Mass Index (BMI) (2010) 0.4 0.6 1.8 -0.8 -0.0 -0.5 -0.4 -0.6 -1.4 -0.6 1.4 0.3 -0.6
Coronary Artery Disease (CAD) 0.7 0.9 2.3 0.1 0.7 0.0 0.3 -0.4 -1.2 -1.1 1.1 -1.5 -1.5
Crohns Disease (2012) 0.2 0.4 2.6 -0.3 0.5 0.1 -0.2 -0.1 -0.4 0.4 -0.3 -0.4 1.6
Mean Putamen Volume 1.0 1.2 4.0 1.1 1.0 0.7 0.7 0.7 -0.1 1.0 0.3 1.8 2.0
Fasting Glucose 0.7 0.8 2.3 -0.8 -0.4 -1.0 -0.4 -0.7 -0.9 -0.4 1.5 1.3 -1.0
HbA1C 1.4 1.5 4.2 1.0 0.8 0.9 1.3 1.2 1.5 1.9 0.0 2.0 0.0
HDL Cholesterol 0.3 0.5 1.1 -0.2 -1.1 -0.9 -0.9 -0.6 0.6 -0.7 -0.9 -0.5 -0.3
LDL Cholesterol 0.2 0.3 1.5 0.2 -0.6 0.2 -0.1 -0.1 1.2 0.1 0.6 -1.0 -0.5
Lupus 0.5 0.7 2.8 -1.7 -0.9 -0.6 -0.3 -0.5 -0.5 -0.4 0.8 1.2 0.3
Neuroticism (2016) 1.0 1.4 6.8 -0.9 -0.8 -0.9 -1.2 -1.4 -2.6 -1.1 0.6 -0.1 0.1
Primary Biliary Cirrhosis 0.7 1.0 2.8 -0.1 1.1 1.0 1.1 1.1 -1.4 0.8 -0.7 0.0 1.7
Rheumatoid Arthritis 0.7 1.0 2.6 0.7 1.6 0.8 1.3 0.9 -0.3 0.8 -1.5 0.1 0.5
Schizophrenia (2014) 4.9 10.7 56.8 -2.9 -1.6 -3.0 -1.9 -2.2 -7.5 -1.9 2.9 -1.3 -2.9
Triglycerides 0.2 0.3 1.8 -1.1 0.0 -0.2 -0.3 -0.2 -1.4 0.2 -0.3 0.2 0.1
Type 2 Diabetes (T2D) (2012) 0.5 0.6 2.6 0.5 1.0 0.6 0.4 0.6 -1.6 1.2 -0.1 0.4 0.4
Ulcerative Colitis 2.0 2.9 7.5 1.3 2.7 1.8 2.0 2.2 -1.3 1.9 0.2 0.9 0.9
Blood Eosinophil Count 0.1 0.7 2.0 -0.5 -0.8 -0.9 -0.9 -0.5 -0.3 -0.3 -1.4 1.3 -0.6
Blood Platelet Count 0.3 3.1 10.6 -0.9 0.5 0.2 1.5 1.2 -1.4 1.4 -3.3 1.9 2.8
Blood Red Count 0.2 1.5 8.5 0.0 -0.3 1.1 1.3 1.2 0.4 0.8 2.9 0.5 0.9
Blood White Count 0.3 1.9 4.8 -1.9 -1.3 -1.2 -0.8 -1.2 0.5 -1.1 -2.2 1.7 1.2
Heel T-Score 0.6 4.5 28.3 -1.1 -2.1 -0.5 -0.9 -0.8 2.1 -1.0 5.3 -1.6 -1.3
BMI 0.5 2.7 8.4 -2.5 -0.3 -1.2 -0.1 -0.7 1.1 -1.1 2.9 0.8 -2.7
Height 0.1 1.4 2.8 0.5 0.9 0.7 0.8 1.4 1.3 1.7 -1.5 1.1 1.1
Waist Hip Ratio (WHR) 0.6 2.8 11.0 1.3 1.8 0.7 1.4 1.1 -3.3 1.6 -1.1 1.4 1.6
Systolic Blood Pressure 0.3 1.4 4.2 0.6 0.9 1.0 1.4 1.4 2.0 1.1 0.6 1.4 -0.2
Smoking Status 0.3 0.7 2.9 -0.7 -0.5 -0.4 -0.3 -0.1 -1.7 0.4 1.4 -0.3 -0.7
Allergy or Eczema 0.8 2.2 3.7 -0.8 -1.3 -1.5 -1.5 -1.7 1.6 -1.9 -1.0 -1.5 -1.5
Cardiovascular Disease 0.2 0.7 2.5 -1.6 0.5 -1.0 0.6 -0.2 -0.5 -0.6 0.7 -0.7 -1.2
Hypothyroidism (self reported) 0.3 0.8 5.7 -0.0 -0.0 0.3 -0.3 -0.2 0.8 -0.5 2.4 0.6 -0.6
Respiratory disease 0.7 1.5 3.6 -1.5 -1.0 -1.4 -0.9 -0.9 -0.7 -0.8 -1.9 -1.5 -1.0
Type 2 Diabetes (T2D) (2018) 0.4 0.8 3.3 -0.6 0.7 0.6 1.0 1.0 -0.3 1.1 -0.2 1.8 -0.3
Lung FEV1/FVC ratio 0.2 1.2 4.2 2.0 0.9 1.1 0.8 1.1 1.3 0.7 1.2 -0.7 -0.4
Lung FVC 0.4 1.9 4.6 -0.6 -1.4 -1.4 -2.1 -2.1 -0.3 -1.7 -1.2 0.2 -0.9
Neuroticism 0.8 1.9 8.2 -1.1 -0.7 -1.4 -1.2 -1.8 -2.9 -1.6 0.5 -0.4 -0.4
Chronotype (morning person) 0.7 1.5 6.2 -0.3 0.9 0.9 1.0 0.8 1.1 1.0 -1.6 0.8 2.5
Hair Pigment 0.0 1.1 2.3 0.9 1.1 0.9 1.2 1.3 -0.3 1.5 -0.7 0.6 1.4
Tanning 0.0 0.4 1.9 -0.7 -0.5 -0.1 -0.4 -0.1 -1.4 0.5 0.1 0.7 -0.6
Hand grip strength (left) 0.4 1.0 2.5 1.4 0.6 0.9 1.3 1.6 0.0 1.3 -0.4 0.3 0.8
Number of treatments/medications taken 1.7 3.0 9.9 -3.1 -0.8 -1.4 -1.1 -1.5 -0.6 -1.5 2.4 -0.8 -2.3
Average weekly spirits intake 0.5 0.6 1.2 -0.9 -0.7 -0.8 -0.4 -0.6 1.0 -1.0 0.5 0.1 -1.1
Sensitivity / hurt feelings 0.9 1.6 3.2 -1.0 -1.1 -1.8 -1.4 -1.7 -1.2 -1.3 -0.9 -1.3 0.1
Frequency of depressed mood in last 2 weeks 0.8 1.2 4.9 -2.2 -0.4 -1.1 -0.7 -0.7 -1.6 -0.4 1.0 -0.7 -0.3
Hearing difficulty/problems: Yes 0.4 0.6 2.2 -0.9 -0.2 -0.5 -0.1 -0.4 1.0 -0.4 0.8 -0.4 -1.5
Relative age of first facial hair 1.9 3.9 9.8 2.5 2.3 3.1 2.1 2.4 -0.5 1.8 -1.0 0.9 1.4
Other serious medical condition/disability diagnosed by doctor 2.1 2.8 5.3 -2.0 -1.1 -2.3 -2.2 -2.3 -1.3 -1.8 0.3 -0.9 -1.2
Ever used hormone-replacement therapy (HRT) 3.1 4.0 7.1 -2.7 -2.3 -2.1 -2.0 -2.2 -0.9 -2.4 1.5 -0.9 -2.2
Ever had hysterectomy (womb removed) 0.5 0.6 3.1 -0.2 -0.5 -0.5 -0.4 -0.5 1.8 -1.0 -0.8 -0.3 -0.6
Systolic blood pressure, automated reading 0.5 1.3 3.8 -1.7 -0.9 -0.6 -0.7 -0.8 2.0 -0.7 1.7 -0.1 -1.0
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 1.1 0.4 0.7 0.1 0.5 0.6 0.6 1.1 -0.1 0.6 0.2
Angina 1.2 1.6 4.8 -2.2 -1.2 -1.5 -0.7 -0.9 -0.2 -0.8 1.9 -0.4 -1.2
Medication for hormone replacement therapy 1.8 2.0 4.3 -0.6 -2.1 -1.6 -1.0 -1.4 -2.1 -1.5 1.0 -0.8 -1.3
Vitamin and mineral supplements 1.5 2.1 3.7 1.5 1.7 1.3 1.4 1.4 0.2 1.4 -0.9 1.9 1.9
Supplements: Zinc 0.4 0.5 1.7 -0.9 -0.9 -0.7 -0.5 -0.4 -0.3 -0.5 -0.0 -0.6 -1.3
Medication: Co-codamol 0.4 0.5 2.8 0.0 0.1 0.1 -0.7 0.0 1.7 -0.2 -0.2 -0.7 -0.8
Medication: Metformin 0.4 0.5 2.9 -0.1 -0.4 0.4 0.2 0.3 -0.5 0.9 0.4 1.7 0.9
Diabetes (father) 0.5 0.6 2.4 -0.7 -0.8 -0.9 -0.4 -0.2 -0.9 -0.0 1.1 -0.2 -1.5
Diabetes (mother) 0.2 0.3 0.9 -0.8 -0.1 0.5 0.1 -0.1 0.7 0.3 -0.9 0.1 0.8
Severe depression (siblings) 0.4 0.4 1.0 0.6 0.6 0.7 0.4 1.0 -0.9 1.0 -0.3 -0.1 0.5
Pack years adult smoking proportion 3.6 5.5 11.2 -0.1 1.5 1.4 2.5 2.4 2.4 3.3 -1.9 2.9 3.1
Impedance of leg (right) 0.5 2.2 11.0 1.0 -0.5 1.0 0.8 1.1 -3.3 1.4 0.9 0.9 1.9
Leg fat-free mass (left) 0.4 2.1 7.1 -2.1 -0.4 -1.5 -0.9 -0.9 2.7 -0.7 0.0 -0.1 -2.2
Trunk fat percentage 0.8 3.3 12.7 -2.8 -1.8 -0.9 -1.4 -1.4 1.0 -1.1 3.6 0.3 -1.3
Hand grip strength (right) 0.5 1.3 2.7 1.4 0.6 1.1 1.3 1.6 -0.2 1.4 0.4 1.2 1.0
Townsend deprivation index at recruitment 0.3 0.4 1.6 0.0 0.1 -0.0 0.5 0.1 0.5 -0.1 -0.9 -1.2 -1.3
Current tobacco smoking 0.2 0.3 0.7 -0.9 -0.5 -0.7 -0.7 -0.6 0.6 -0.1 -0.4 -0.6 -0.4
Average weekly fortified wine intake 0.8 0.9 1.6 0.1 1.1 1.3 0.9 1.0 -1.1 1.3 -0.3 0.5 1.1
Maternal smoking around birth 0.6 0.8 2.8 -0.2 0.0 -0.2 1.4 0.7 -0.5 1.2 0.6 0.6 1.7
Fed-up feelings 0.6 1.1 3.2 -1.1 -0.6 -1.3 -0.7 -1.4 1.8 -1.1 -0.0 -0.5 -0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.2 0.8 -0.9 0.4 -0.7 0.1 0.1 0.8 0.2 -0.2 0.0 -0.3
Relative age voice broke 2.3 3.5 8.3 2.6 2.3 2.9 1.8 2.2 -1.6 1.0 -0.5 1.6 -0.0
Taking other prescription medications 0.5 0.8 3.3 -1.4 -0.4 -0.8 0.4 -0.1 -0.1 0.6 1.8 1.0 -0.2
Age when periods started (menarche) 1.5 3.5 7.8 1.1 2.3 1.3 1.7 1.8 -2.8 2.1 -1.0 1.2 2.6
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 2.2 1.0 1.1 0.5 1.0 1.1 1.5 0.6 -0.3 0.2 -0.9
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 2.6 -0.2 0.1 0.5 0.2 0.5 1.6 0.4 1.1 -0.6 -0.3
Tinnitus: Yes, but not now, but have in the past 1.0 1.0 2.2 0.5 1.4 0.7 1.5 1.2 -0.9 1.4 0.0 0.1 1.1
Qualifications: CSEs or equivalent 0.8 1.1 6.8 -0.6 0.5 -0.1 0.9 0.4 2.6 0.5 1.1 -1.0 0.3
Serious illness, injury or assault to yourself 0.4 0.5 1.5 0.4 0.1 -0.8 -0.5 -0.5 -0.8 -0.5 -0.2 -1.2 -1.1
High blood pressure 0.1 0.3 0.8 -0.8 0.4 0.5 0.6 0.0 -0.9 -0.5 0.3 0.0 -0.1
Hayfever, allergic rhinitis or eczema 0.7 1.5 3.7 -0.6 -0.5 -1.2 -0.7 -1.0 1.9 -1.4 -1.2 -1.4 -1.6
Multivitamins +/- minerals 3.9 5.0 7.4 -2.5 -2.7 -2.7 -2.4 -2.3 0.3 -1.9 1.9 -2.3 -2.3
Stomach or abdominal pain in last month 0.6 0.8 2.2 -0.8 1.1 0.4 1.0 0.9 1.0 1.5 -0.4 0.5 0.4
Supplements: Glucosamine 0.2 0.3 1.0 0.0 0.1 0.3 -0.4 -0.1 -1.0 -0.1 0.4 -0.7 -1.0
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 1.2 -0.2 0.5 0.1 -0.5 -0.2 0.3 -0.4 -1.1 0.0 -0.2
Medication: Atenolol 0.4 0.5 1.6 -0.8 0.1 -0.4 0.5 -0.1 -1.3 0.6 0.7 1.2 0.2
Medication: Levothyroxine sodium 0.5 0.9 2.8 0.3 1.1 0.7 1.1 0.8 0.6 0.6 1.7 0.9 0.9
Sitting height 0.2 1.2 3.3 -1.1 -0.6 -0.0 0.4 0.9 0.8 1.7 -0.7 1.8 1.5
Chronic bronchitis/emphysema (father) 3.6 4.3 10.2 -2.8 -3.2 -2.6 -2.7 -2.6 0.3 -1.6 -0.2 -0.3 1.0
High blood pressure (mother) 0.5 0.7 3.7 -0.1 -1.0 -0.8 -0.4 -0.8 0.9 -0.7 -0.1 -1.9 -0.2
Body mass index (BMI) 0.8 3.4 11.8 -2.5 -0.7 -1.1 -1.1 -1.3 3.4 -1.6 2.1 -0.3 -2.2
Impedance of leg (left) 0.6 2.8 14.8 0.9 -0.6 1.1 0.8 1.0 -3.8 1.3 1.0 0.9 2.4
Leg predicted mass (left) 0.4 2.2 6.8 -2.2 -0.5 -1.6 -1.0 -1.0 2.6 -0.8 -0.0 -0.1 -2.2
Trunk fat mass 0.8 3.3 10.6 -2.9 -1.6 -1.2 -1.4 -1.3 1.4 -1.1 3.2 0.4 -1.7
Waist circumference 0.4 1.3 3.6 -1.9 -0.2 -0.9 -0.6 -0.8 1.6 -0.7 1.7 0.2 -1.2
Number of incorrect matches in round 1.2 1.9 6.4 -1.3 -2.1 -1.4 -1.3 -1.3 -2.5 -0.9 0.9 0.4 0.1
Past tobacco smoking 0.8 1.4 5.3 1.3 1.3 0.6 1.3 1.1 2.3 0.6 -1.1 -0.1 0.9
Alcohol usually taken with meals 3.4 5.5 11.5 1.8 1.8 3.0 2.6 2.5 -1.5 3.0 -0.8 1.9 3.4
Nervous feelings 1.1 2.1 9.6 -1.3 -1.1 -1.0 -1.1 -1.2 -3.1 -1.3 1.1 -1.0 -0.5
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.4 -1.0 -1.0 -1.1 -0.4 -0.7 -1.2 -0.4 0.3 0.3 0.1
Hearing difficulty/problems with background noise 0.9 1.4 3.2 -1.0 -0.8 -1.4 -1.3 -1.3 -0.3 -1.3 1.8 -0.8 -1.3
Hair/balding pattern: Pattern 2 1.1 1.3 3.4 1.1 1.8 1.4 1.1 1.3 -0.9 1.5 -0.5 -0.2 0.8
Had menopause 0.7 0.9 4.3 -2.1 -1.1 -0.6 -0.9 -1.0 -0.0 -0.8 -0.2 0.0 0.7
Had other major operations 0.8 1.0 2.2 1.3 0.8 1.5 1.4 1.4 0.6 0.8 0.8 0.2 -0.1
Forced vital capacity (FVC) 0.2 0.7 3.8 0.8 0.5 -0.0 -0.2 0.5 -0.1 0.7 -1.9 1.1 -0.0
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.2 3.5 -0.1 0.9 1.6 0.8 1.4 1.9 1.0 1.1 -0.0 0.2
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 2.9 0.4 0.6 -0.7 0.8 0.4 1.2 -0.2 1.0 -0.5 -1.7
Qualifications: None of the above 1.2 2.6 8.0 -1.9 -2.3 -2.8 -1.3 -2.0 1.1 -1.3 0.8 -0.0 -0.6
Financial difficulties in last 2 years 0.8 1.1 3.4 -0.9 0.4 -0.7 -0.7 -0.7 1.9 -1.0 -1.1 -0.7 -1.4
Mouth/teeth dental problems 0.4 0.5 2.7 1.6 0.7 0.9 -0.1 0.4 -0.4 0.4 0.1 1.0 0.2
Heart attack 0.4 0.5 0.9 -0.8 -0.6 -0.2 -0.6 -1.0 -0.7 -0.9 0.6 -0.8 0.3
Allergy 0.5 1.1 2.4 1.1 -0.1 0.7 0.4 0.5 -1.4 0.9 1.4 1.6 1.2
Pain all over the body in last month 0.6 0.6 1.6 0.8 0.9 0.8 1.3 0.9 0.4 0.7 0.5 0.4 0.7
Diabetes (self-reported) 0.2 0.3 1.8 -0.4 0.3 -0.0 0.4 0.4 -0.0 0.4 -0.6 1.3 -0.4
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 1.3 -0.1 0.6 -0.1 0.5 0.3 0.6 0.5 -1.1 0.8 0.2
Medication: Ramipril 0.3 0.4 1.4 -1.2 0.6 0.3 0.1 -0.1 -0.3 -0.5 -0.0 -0.9 -1.0
Medication: Simvastatin 0.3 0.4 2.1 -1.4 1.1 -0.0 0.1 -0.3 0.4 -0.5 -0.6 -0.2 -0.4
Fluid intelligence score 1.5 3.2 6.6 2.3 2.6 2.3 1.4 1.7 -0.4 1.4 -0.8 2.2 1.4
Illnesses of siblings 1.0 1.4 9.5 0.0 -0.8 -0.9 -1.4 -0.9 -0.3 -0.3 -3.1 -0.1 0.2
Neuroticism score 0.7 1.4 5.5 -0.8 -0.6 -1.2 -1.0 -1.5 -2.3 -1.5 0.0 -0.6 -0.6
Weight 0.5 2.3 6.4 -2.5 -0.7 -1.1 -1.0 -0.9 2.5 -0.9 1.5 0.0 -1.9
Impedance of arm (right) 0.4 1.8 12.3 1.0 -0.6 0.8 -0.6 0.1 -3.5 0.7 -0.6 0.5 1.4
Arm fat percentage (right) 0.8 3.3 8.0 -2.2 -1.4 -1.1 -1.6 -1.6 2.2 -1.5 2.8 -0.4 -2.1
Trunk fat-free mass 0.3 1.7 5.5 -1.8 -0.2 -1.6 -0.7 -0.8 2.3 -0.7 -0.4 -0.5 -2.0
Hip circumference 0.8 3.6 7.5 -2.7 -1.2 -1.4 -1.2 -1.3 2.6 -1.4 2.7 -0.6 -2.2
Time employed in main current job 1.2 1.4 11.2 1.1 0.7 0.2 0.1 0.2 3.3 0.2 -0.7 0.3 -0.2
Alcohol intake versus 10 years previously 0.4 0.6 3.0 -0.8 0.5 -0.5 0.5 0.1 0.9 -0.1 -1.1 0.2 -1.7
Father’s age at death 1.0 1.3 4.5 2.1 0.5 0.9 0.4 0.7 -1.3 1.1 0.6 0.7 1.9
Worrier / anxious feelings 1.1 2.0 18.4 0.3 -0.2 -0.9 -0.3 -0.4 -4.3 -0.4 0.3 0.2 -0.0
Frequency of tiredness / lethargy in last 2 weeks 1.3 2.2 7.1 -1.1 -1.6 -2.7 -1.5 -1.7 1.6 -0.9 1.0 0.2 -1.1
Falls in the last year 0.9 1.2 2.4 1.2 0.7 0.9 0.8 0.9 -1.6 1.2 -0.8 1.1 1.5
Hair/balding pattern: Pattern 3 1.0 1.4 3.8 -1.9 -1.3 -0.9 -0.6 -1.1 -0.4 -1.4 0.6 -1.8 -0.9
Number of live births 0.5 0.7 4.2 0.4 0.0 0.2 1.0 0.7 2.1 0.6 -0.3 -0.0 0.5
Forced expiratory volume in 1-second (FEV1) 0.1 0.2 0.9 0.8 0.4 -0.3 -0.4 0.1 -0.2 0.2 -0.9 0.4 -0.6
Pulse rate 1.2 2.0 9.4 0.1 -1.5 -1.0 -1.0 -1.1 3.1 -1.0 -1.2 -1.4 -0.8
Happiness 0.5 0.6 1.3 -0.6 -0.7 -0.7 -0.5 -0.6 1.0 -0.6 1.1 -0.7 -0.8
Noisy workplace 0.3 0.4 2.9 -0.0 0.3 0.2 -0.2 -0.2 -0.0 -0.4 -0.2 -1.7 -1.0
Qualifications: A levels/AS levels or equivalent 0.4 0.9 3.4 -0.7 -0.9 -0.3 -1.9 -1.3 0.6 -0.9 -0.7 -1.0 0.1
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 2.0 -0.9 0.4 0.5 0.7 0.9 0.9 0.8 0.0 1.4 0.6
Mouth/teeth dental problems: Dentures 0.8 1.3 6.4 -1.3 -0.9 -0.9 -0.7 -1.0 0.3 -0.7 -2.5 -0.1 0.9
Asthma 0.2 0.5 3.0 -0.9 -0.1 -0.4 -0.2 0.1 0.2 0.2 -1.7 -0.7 -0.2
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 1.1 -0.3 -0.1 -0.7 -0.6 -0.7 0.5 -1.0 0.2 -0.1 -0.9
Medication: Cholesterol lowering 0.2 0.3 1.3 -1.2 0.9 0.5 0.4 0.3 -0.3 0.3 0.1 0.1 0.0
Depression (self-reported) 1.9 2.3 5.9 -1.7 -0.8 -1.9 -1.1 -1.6 0.7 -1.8 0.7 -1.4 -2.4
Medication: Lansoprazole 0.5 0.6 4.7 0.5 -0.1 0.0 0.1 0.2 2.2 -0.1 -0.4 0.4 -0.9
Prospective memory result 1.5 1.9 4.9 -0.9 -1.9 -2.2 -1.1 -1.6 -1.6 -0.9 0.6 -1.0 -1.0
Lung cancer (father) 0.4 0.5 2.3 0.1 0.3 -0.2 0.6 0.8 0.5 1.5 -0.5 0.6 0.9
Illnesses of mother 1.2 1.4 3.3 1.1 1.8 1.8 1.2 1.5 -1.0 1.1 -0.7 0.6 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.0 0.1 0.4 0.2 0.2 -0.5 -0.2 -0.0 -0.2 0.0 -0.5 -0.6 -0.5
Pulse wave Arterial Stiffness index 0.2 0.3 1.3 -0.2 -0.9 0.1 -0.5 -0.4 1.1 -0.1 0.4 -0.1 -0.1
Impedance of arm (left) 0.6 2.6 12.1 1.5 0.1 1.5 0.5 1.2 -3.5 1.7 -0.1 1.1 1.9
Arm fat mass (right) 0.8 3.4 6.6 -2.6 -1.4 -1.4 -1.6 -1.6 2.6 -1.5 2.3 -0.2 -2.1
Trunk predicted mass 0.3 1.7 5.7 -1.7 -0.1 -1.6 -0.6 -0.7 2.4 -0.6 -0.4 -0.5 -2.0
Standing height 0.1 1.1 3.6 -0.2 0.3 0.4 0.6 1.2 -1.6 1.9 -0.8 1.3 0.5
Length of working week for main job 5.8 6.4 13.5 -2.0 -2.4 -3.7 -2.8 -3.2 -0.7 -2.8 0.0 -2.2 -3.0
Exposure to tobacco smoke at home 0.5 0.6 1.4 -0.4 -0.9 -0.4 -1.1 -1.2 -0.6 -1.2 0.4 -0.6 0.3
Breastfed as a baby 0.4 0.5 2.3 0.5 -0.1 0.7 0.2 0.3 -0.5 0.3 1.1 1.5 -0.5
Tense / ‘highly strung’ 2.6 4.3 19.5 -1.9 -1.9 -2.2 -1.7 -2.0 -4.4 -1.2 1.5 -0.2 0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 2.4 3.6 8.7 -2.0 -2.2 -3.0 -1.8 -2.4 -1.9 -2.0 0.9 -0.9 -0.2
Hair/balding pattern: Pattern 4 0.2 0.6 3.6 0.1 0.3 -0.5 0.1 0.1 1.9 0.0 1.0 0.8 -0.6
Birth weight of first child 1.5 2.7 4.3 -1.2 -1.9 -1.8 -2.0 -2.1 1.4 -1.9 1.5 -1.2 -1.2
Peak expiratory flow (PEF) 0.3 0.7 2.1 0.9 -0.2 -0.4 -1.0 -0.6 -1.4 -0.8 -0.8 -1.0 -0.8
Pulse wave reflection index 0.2 0.2 0.9 -0.3 0.4 1.0 0.3 0.2 0.1 -0.1 0.5 0.6 -0.1
Ever highly irritable/argumentative for 2 days 3.5 4.2 9.2 2.2 2.7 2.9 3.0 2.8 0.4 1.9 0.2 0.4 0.5
Loud music exposure frequency 0.6 0.7 4.2 1.2 0.8 0.1 0.1 -0.1 -0.1 -0.4 0.2 -0.7 -2.1
Qualifications: O levels/GCSEs or equivalent 0.6 1.0 2.5 -1.3 -0.6 -0.2 -1.6 -0.8 -1.1 -0.7 -1.0 -1.0 1.2
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.7 -1.3 -0.2 -0.3 0.1 0.2 0.6 -0.0 1.0 -0.5 -0.7
Blood clot in the leg (DVT) 0.7 0.9 2.5 -0.1 1.4 1.6 0.5 1.1 -0.2 1.3 0.4 0.2 0.8
Medication: Paracetamol 0.7 1.1 5.1 -0.5 -0.8 -0.9 -0.7 -0.9 0.6 -0.7 2.3 -0.9 -1.2
Headache pain in last month 0.5 0.8 5.3 -0.6 -0.2 -0.6 -0.3 -0.6 2.3 -0.5 -0.6 -0.7 -0.8
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 2.4 1.5 -0.8 -0.4 -0.2 -0.0 0.4 0.1 0.3 -0.1 0.0
Glaucoma (self-reported) 2.1 2.5 5.8 2.4 1.5 1.8 1.8 1.7 -0.1 1.1 2.3 0.7 -0.6
Gout (self-reported) 0.6 0.8 3.3 0.0 -0.3 -1.1 -0.5 -0.8 -1.1 -0.9 -1.8 0.3 -0.5
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 4.7 0.3 0.1 0.4 0.2 -0.0 0.3 -0.2 2.2 0.7 0.2
Medication: Amlodipine 0.4 0.6 1.9 -1.3 -0.2 -0.4 -0.3 -0.6 -0.0 -1.0 0.1 -0.8 -1.4
Medication: Ventolin 100micrograms inhaler 0.9 1.2 2.8 0.3 1.1 0.4 1.6 1.3 -1.7 1.3 -0.2 -1.0 0.3
Birth weight 1.7 3.6 7.5 -2.6 -2.6 -1.5 -2.7 -2.4 -0.7 -2.2 -0.1 -1.1 0.2
Chronic bronchitis/emphysema (mother) 0.4 0.4 1.4 -1.2 -0.8 -0.9 -0.4 -0.5 0.4 0.1 0.1 0.2 0.8
High blood pressure (siblings) 0.9 1.3 6.7 0.4 0.0 1.2 0.7 0.6 -0.1 0.4 2.6 1.2 1.4
Forced vital capacity (FVC), Best measure 0.1 0.3 1.8 0.3 0.5 -0.2 0.1 0.3 -0.6 0.6 -1.3 0.1 0.1
Body fat percentage 0.9 3.4 12.4 -2.7 -1.8 -1.1 -1.4 -1.4 1.5 -1.3 3.5 0.4 -1.4
Leg fat percentage (right) 0.8 2.8 14.0 -1.9 -1.1 -0.7 -0.6 -0.7 2.2 -1.0 3.7 0.7 -1.4
Arm fat-free mass (right) 0.4 1.8 5.7 -2.2 -0.2 -1.4 -0.2 -0.5 2.4 -0.6 0.7 -0.1 -2.1
Exposure to tobacco smoke outside home 1.1 1.4 2.7 0.8 1.4 1.6 1.3 1.2 1.6 1.1 1.0 -0.1 0.7
Comparative body size at age 10 0.6 1.6 11.0 -0.1 -0.9 -1.0 -0.8 -0.5 3.3 -0.6 0.4 -0.7 -1.3
Number of full brothers 0.9 1.1 2.6 0.8 1.3 0.3 1.6 1.2 1.5 1.4 0.4 0.3 0.6
Worry too long after embarrassment 0.9 1.5 3.8 -1.0 -1.0 -1.4 -1.1 -1.2 -1.9 -0.8 1.9 -0.6 -0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.0 8.2 -0.3 -0.1 -1.0 0.2 -0.4 -2.9 -0.4 0.4 -0.7 -0.3
Wheeze or whistling in the chest in last year 0.2 0.4 1.7 -0.4 -0.1 -0.4 0.3 0.4 0.9 0.4 -0.6 1.3 0.1
Number of children fathered 1.5 1.7 4.7 0.9 1.4 1.2 1.0 1.3 -1.1 1.3 0.1 1.8 2.2
Reason for reducing amount of alcohol drunk: Health precaution 1.5 1.8 6.6 0.1 0.7 1.2 1.1 1.4 -2.6 1.4 0.3 1.7 0.9
Age at first live birth 0.5 0.8 3.4 0.5 0.6 0.9 0.4 0.9 -1.9 0.5 -0.3 -0.1 1.4
Pulse wave peak to peak time 0.3 0.4 1.4 0.3 1.1 -0.0 0.7 0.6 -1.2 0.5 -0.4 0.2 0.1
Health satisfaction 0.2 0.2 1.3 -0.2 -0.4 -0.6 0.3 -0.0 0.2 0.0 1.1 0.2 -0.2
Shortness of breath walking on level ground 0.4 0.4 1.6 -0.8 0.1 -0.3 -0.1 -0.6 -0.1 -0.8 1.3 1.0 -0.3
Qualifications: College or University degree 0.6 1.9 5.8 1.7 1.4 2.4 0.4 1.2 -2.1 0.8 -0.4 -0.1 1.0
Eye problems/disorders: None of the above 1.6 1.8 2.8 -0.7 -1.7 -1.5 -1.7 -1.4 0.4 -1.5 -0.7 -1.6 -1.6
Mouth/teeth dental problems: Loose teeth 1.9 2.2 5.7 -1.6 -1.8 -1.9 -1.2 -1.5 -0.3 -0.9 2.4 -0.7 -1.3
Emphysema/chronic bronchitis 1.2 1.4 3.1 -1.4 -1.3 -1.2 -0.6 -1.0 -1.8 -0.7 -0.9 -1.7 -0.1
Medication for pain relief, constipation, heartburn 0.9 1.6 5.2 2.3 1.0 1.1 0.9 1.2 1.2 0.7 -2.0 -0.0 0.5
Neck or shoulder pain in last month 0.5 0.7 2.7 -0.9 -0.4 -0.6 0.0 0.1 -1.6 0.1 0.9 1.3 0.4
Medication: Blood pressure 0.3 0.4 1.4 -0.3 1.2 1.1 0.9 0.6 -0.4 0.3 0.3 0.5 0.0
Angina (self-reported) 1.1 1.5 5.4 -2.3 -1.1 -1.3 -0.7 -0.9 -0.3 -0.8 1.8 -0.2 -1.1
Migraine (self-reported) 1.2 1.5 2.8 0.7 1.5 1.2 1.5 1.7 -0.1 1.6 -0.4 1.5 0.6
Medication: Ibuprofen 0.7 0.9 1.6 -1.0 -0.5 -1.0 -1.1 -1.1 -0.0 -1.2 0.7 -0.7 -1.3
Medication: Allopurinol 0.6 0.8 2.3 0.3 -0.8 -1.5 -0.4 -1.0 -1.1 -1.2 -0.1 0.4 -1.2
Medication: Omeprazole 2.0 2.4 5.9 -2.4 -1.2 -1.5 -2.0 -2.0 -0.8 -1.9 1.1 -0.4 -1.2
Medication: Seretide 50 evohaler 1.9 2.2 4.5 -1.3 -1.7 -1.9 -1.3 -1.4 -2.1 -1.0 1.8 -1.2 0.8
Mean time to correctly identify matches 0.4 0.7 2.8 -0.3 -0.6 -0.5 -0.8 -1.3 0.9 -0.5 -0.7 -1.7 0.5
Heart disease (mother) 0.4 0.5 2.7 -1.1 -0.4 -0.3 0.2 -0.1 -0.4 -0.2 1.6 0.7 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 4.7 5.6 11.8 -1.8 -3.0 -2.9 -2.7 -2.7 0.2 -3.4 -0.6 -1.9 -2.3
Whole body fat mass 0.9 3.8 9.5 -3.0 -1.7 -1.5 -1.6 -1.6 1.9 -1.5 3.1 0.2 -2.0
Leg fat mass (right) 0.8 3.1 8.2 -2.4 -1.1 -1.3 -1.0 -1.2 2.5 -1.2 2.9 0.5 -1.8
Arm predicted mass (right) 0.4 2.3 6.7 -2.5 -0.6 -1.8 -0.4 -0.8 2.6 -0.7 0.7 -0.3 -2.1
Pulse rate, automated reading 1.2 3.9 8.7 -2.1 -1.1 -1.7 -1.7 -1.7 2.9 -2.0 -1.7 -2.0 -2.3
Alcohol intake frequency. 1.3 2.9 6.4 -2.5 -0.8 -1.7 -1.4 -1.7 1.5 -1.7 -2.4 -1.4 -1.4
Comparative height size at age 10 0.6 3.1 8.4 -2.9 -2.5 -2.6 -2.1 -1.4 0.2 -0.6 0.1 -0.5 -1.8
Number of full sisters 0.3 0.3 0.9 0.2 0.7 0.4 0.6 0.9 0.2 0.9 0.3 -0.1 -0.6
Suffer from ‘nerves’ 1.3 2.0 3.7 -1.8 -1.2 -1.9 -1.4 -1.8 -1.0 -1.7 -0.6 -1.3 -1.0
Overall health rating 1.2 2.7 9.2 -2.3 -1.3 -2.1 -1.1 -1.5 3.0 -1.0 0.1 -1.1 -0.1
Chest pain or discomfort 0.4 0.6 2.8 -1.7 -0.3 -0.4 0.2 -0.2 1.3 0.3 0.8 0.8 0.1
Had major operations 3.3 3.9 8.8 -2.2 -1.2 -2.7 -1.5 -2.0 0.3 -2.1 -0.5 -2.4 -3.0
Age at last live birth 0.2 0.3 1.6 -0.5 -0.4 -0.1 -0.1 0.2 -0.2 0.3 -0.4 -1.2 0.6
Family relationship satisfaction 0.4 0.4 1.9 -0.2 0.1 0.1 0.4 0.3 -0.2 0.4 0.7 1.4 1.2
Leg pain on walking 0.2 0.3 0.9 0.6 0.4 -0.1 0.6 0.3 -0.4 0.2 0.5 -0.7 -1.0
Qualifications: NVQ or HND or HNC or equivalent 2.1 2.5 6.1 2.5 1.8 1.7 1.8 1.7 0.3 1.2 -2.2 0.3 0.0
Commuting to job workplace: Car/motor vehicle 1.6 1.9 3.8 -1.0 -1.7 -1.7 -1.3 -1.4 -0.8 -1.6 2.0 -0.8 -0.8
Illness, injury, bereavement, stress in last 2 years 0.7 0.9 1.8 -0.3 -1.3 -1.3 -1.0 -1.3 -1.0 -0.9 -0.1 -0.9 0.2
Medication: Aspirin 2.3 3.0 6.2 -2.5 -1.8 -1.3 -1.2 -1.8 -2.1 -1.5 2.1 -1.7 -0.7
Supplements: Vitamin C 1.3 1.5 5.1 -1.5 -0.5 -0.2 -1.3 -1.0 -1.3 -1.6 -0.1 -1.0 -2.3
Knee pain experienced in last month 0.5 0.8 5.7 0.5 -0.6 -0.3 0.2 -0.3 -0.3 -0.3 2.4 1.2 0.1
Hypertension (Self-reported) 0.2 0.5 1.6 -1.0 0.1 0.2 0.3 -0.2 -1.3 -0.7 0.9 -0.3 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.5 2.2 0.4 0.8 -0.3 1.0 0.5 1.5 0.9 -0.2 0.6 -0.4
Illnesses of father: Heart disease 0.9 1.3 3.6 -0.8 -1.1 -1.7 -0.4 -0.7 0.4 -0.4 1.9 -1.8 -0.9
Illnesses of siblings: Diabetes 0.8 1.0 2.1 0.8 1.0 0.2 1.4 1.2 1.0 1.0 1.4 0.8 0.2
Smoking status: Previous 0.5 0.7 4.3 -0.3 -0.8 -0.1 -0.6 -0.4 -2.1 0.1 0.9 0.6 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 2.7 -0.7 0.2 -0.2 0.7 0.8 -1.6 0.9 -1.6 0.0 -0.0
Whole body fat-free mass 0.3 2.0 6.4 -2.0 -0.4 -1.6 -0.7 -0.9 2.5 -0.7 -0.2 -0.4 -2.1
Leg fat-free mass (right) 0.3 1.8 5.0 -2.1 -0.4 -1.5 -0.9 -1.0 2.2 -0.8 -0.2 -0.1 -2.0
Arm fat percentage (left) 0.7 2.7 7.7 -2.0 -1.1 -0.8 -1.2 -1.2 2.3 -1.2 2.8 -0.0 -1.8
Average weekly red wine intake 2.1 3.1 5.6 1.1 1.4 2.3 2.1 2.4 -2.0 2.1 0.3 0.8 1.8
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.8 0.4 -0.1 -0.7 0.5 0.2 0.2 0.3 -1.0 1.1 1.3
Mood swings 0.3 0.5 2.8 -0.1 1.4 0.1 0.3 0.1 -1.7 -0.1 -0.4 -0.2 -0.5
Loneliness, isolation 1.2 1.6 3.1 -1.5 -1.7 -1.8 -1.7 -1.7 0.2 -1.3 -0.2 0.2 -0.7
Long-standing illness, disability or infirmity 0.4 0.7 2.5 -1.6 -0.4 -0.8 -0.4 -0.6 0.8 -0.3 0.0 -0.6 -1.4
Ever had bowel cancer screening 1.2 1.4 4.1 -1.1 -0.7 -0.6 -1.3 -1.3 -1.6 -1.4 0.6 -2.0 -0.3
Diabetes diagnosed by doctor 0.2 0.3 1.7 -0.8 0.0 -0.1 0.3 0.4 -0.1 0.8 -0.2 1.3 0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.6 1.3 -0.3 1.0 0.5 0.8 1.1 -0.8 1.1 -0.7 -0.2 -0.3
Friendships satisfaction 0.6 0.7 2.8 -0.4 -1.3 -0.9 -0.7 -0.7 0.7 -0.3 1.7 -0.5 0.4
Qualifications: nursing, teaching 1.3 2.0 10.2 0.1 -0.1 1.6 -0.3 0.4 -1.8 0.4 -1.8 0.1 3.2
Commuting to job workplace: Walk 4.2 4.6 7.7 2.8 2.4 2.7 2.5 2.5 -0.7 2.0 -0.8 2.0 2.0
Eye problems/disorders: Cataract 0.3 0.3 2.4 0.1 0.5 0.4 0.0 -0.2 -1.5 -0.2 0.2 -0.1 0.5
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 2.4 0.5 0.4 0.6 1.5 0.8 -0.3 1.0 1.1 0.3 -0.1
Medication for cholesterol 0.2 0.4 1.8 0.1 -0.2 -0.3 -0.4 0.2 -0.4 0.7 -0.9 0.3 1.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.1 2.9 -1.7 -0.3 -0.6 -1.2 -1.0 -0.6 -1.3 0.5 -1.0 -1.5
Back pain experienced in last month 0.7 1.0 5.3 -2.3 -0.8 -1.1 -1.0 -1.0 -0.3 -0.4 -0.3 -0.7 0.8
Mineral and other dietary supplements 0.7 0.9 2.8 0.4 0.3 0.2 0.8 0.7 0.9 1.0 -0.4 1.7 1.7
Breast cancer (self-reported) 1.1 1.3 2.8 1.6 1.2 1.7 1.4 1.5 -0.3 0.9 1.0 0.5 -0.1
Asthma (self-reported) 0.2 0.4 2.5 -0.9 -0.1 -0.4 -0.2 0.1 -0.1 0.2 -1.6 -0.7 0.0
Osteoporosis (self-reported) 0.2 0.3 0.9 0.7 0.1 0.2 0.1 -0.0 -0.8 -0.0 -1.0 -0.2 0.9
Osteoarthritis (self-reported) 0.2 0.3 1.1 -0.8 0.8 0.2 0.4 0.2 -1.1 0.3 -0.1 0.2 0.2
Medication: Aspirin 3.1 4.1 8.2 -2.9 -2.1 -1.6 -1.5 -2.1 -2.3 -1.8 2.3 -1.7 -1.4
Medication: Gliclazide 1.4 1.6 5.6 -2.4 -1.6 -1.7 -1.1 -1.4 0.2 -0.7 1.0 -0.7 0.1
Illnesses of father: None of the above (group 1) 1.3 1.6 6.4 0.7 1.9 1.6 1.0 1.0 0.3 0.4 -2.5 0.2 -0.1
Smoking status: Current 0.5 0.7 1.2 -1.1 -0.6 -1.1 -1.0 -1.0 0.4 -0.6 -0.3 -0.9 -1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 2.7 1.6 0.8 0.7 0.1 -0.0 -0.3 -0.4 -0.1 -0.8 -0.3
Whole body water mass 0.3 1.8 6.5 -1.9 -0.2 -1.4 -0.6 -0.7 2.6 -0.6 -0.2 -0.3 -2.1
Leg predicted mass (right) 0.3 1.8 5.0 -2.1 -0.3 -1.5 -0.9 -0.9 2.2 -0.8 -0.3 -0.2 -2.0
Arm fat mass (left) 0.7 3.0 8.3 -2.3 -1.1 -1.1 -1.1 -1.1 2.9 -1.1 2.6 0.2 -1.9
Number of self-reported non-cancer illnesses 0.3 0.5 2.2 -1.5 0.9 -0.1 0.4 0.1 -0.3 0.0 0.8 -0.3 -1.0
Average weekly champagne plus white wine intake 1.0 1.4 4.5 1.4 0.8 2.1 0.7 0.8 -0.6 0.7 1.8 0.8 0.6
Miserableness 0.2 0.4 1.3 -0.5 0.6 0.3 0.2 -0.1 -1.1 -0.3 0.1 -0.7 -1.1
Guilty feelings 0.5 0.8 1.9 -0.1 0.9 0.7 -0.6 -0.5 -0.6 -1.2 -1.0 -1.0 -1.4
Wears glasses or contact lenses 0.8 1.0 4.7 -1.2 -0.6 -0.9 0.2 -0.3 2.2 -0.1 -0.3 -1.4 -0.0
Ever taken oral contraceptive pill 1.2 1.3 4.2 -1.1 0.5 -0.1 0.0 0.1 1.9 -0.3 -2.0 -1.6 -1.2
Hearing aid user 0.5 0.6 1.9 -0.5 -0.7 -0.4 -0.1 -0.5 -0.4 -0.9 1.4 -0.9 -0.9
Mother’s age at death 0.4 0.5 1.8 1.0 -1.0 -0.0 -0.5 -0.3 0.0 -0.4 1.4 0.7 0.6
Financial situation satisfaction 1.3 1.6 9.1 -1.3 -0.5 -1.0 -0.4 -0.7 3.0 -0.9 -0.5 -1.3 -0.6
Tinnitus: Yes, now most or all of the time 2.9 3.4 7.1 -1.5 -1.2 -2.0 -2.5 -2.6 0.2 -2.7 -0.2 -1.2 -2.2
Commuting to job workplace: Public transport 2.0 2.4 7.2 1.8 2.7 2.1 1.3 1.7 0.2 1.5 -1.4 0.4 -0.2
Eye problems/disorders: Glaucoma 3.1 3.7 6.1 2.3 2.0 2.5 2.4 2.3 -0.1 1.8 2.3 1.3 -0.3
Medication: Blood pressure 0.2 0.4 1.0 -0.1 1.0 1.0 0.9 0.8 -0.0 0.3 0.5 0.8 0.2
Pain type(s) experienced in last month: Hip pain 0.8 1.1 2.0 -0.7 -0.4 -1.1 -1.0 -1.4 1.1 -1.1 -1.4 -1.0 -0.4
Supplements: Fish oil (including cod liver oil) 0.6 0.7 3.1 -0.4 0.1 -0.1 -0.6 -0.5 -0.7 -0.8 0.4 -1.5 -1.8
High cholesterol (Self-reported) 0.2 0.4 2.6 -1.6 0.5 -0.1 0.1 0.1 -0.1 0.2 0.7 -0.0 -0.5
Medication: Bendroflumethiazide 0.2 0.3 1.0 -1.0 0.6 0.3 0.4 0.1 -0.8 0.0 0.2 0.6 -0.2
Medication: Paracetamol 1.3 2.1 6.2 -0.9 -1.2 -1.5 -1.0 -1.3 0.1 -1.2 2.5 -1.5 -1.9
Medication: Lisinopril 0.2 0.2 1.1 -0.1 0.3 0.3 0.1 0.1 -0.9 -0.0 1.1 -0.3 0.0
Medication: Atorvastatin 1.2 1.5 2.8 -1.6 -1.7 -0.9 -1.2 -1.2 0.7 -1.1 0.4 -1.0 -1.6
Illnesses of father: High blood pressure 2.8 3.5 6.4 -1.8 -2.3 -2.5 -2.1 -2.3 -1.1 -1.8 1.6 -1.2 -1.2
Alcohol drinker status: Never 1.2 1.4 3.0 -1.2 -1.3 -0.9 -1.7 -1.7 -0.3 -1.4 -1.5 0.0 0.0
Ever smoked 0.5 0.9 4.2 -1.5 -0.6 -0.1 -0.8 -0.5 -2.1 0.0 1.0 0.3 -0.5
Basal metabolic rate 0.4 2.0 6.8 -2.1 -0.4 -1.5 -0.8 -0.9 2.6 -0.7 0.2 -0.3 -2.1
Leg fat percentage (left) 0.8 2.9 15.3 -2.0 -1.2 -0.8 -0.7 -0.9 1.9 -1.1 3.9 0.5 -1.2
Arm fat-free mass (left) 0.5 2.3 6.9 -2.3 -0.5 -1.4 -0.7 -1.0 2.6 -1.1 0.6 -0.4 -2.3
Number of operations (self-reported) 2.0 2.9 7.9 -1.9 -0.7 -1.9 -1.2 -1.5 -0.1 -2.0 -0.4 -2.4 -2.8
Average weekly beer plus cider intake 2.6 3.7 8.6 -2.5 -2.0 -2.9 -2.5 -2.2 0.0 -1.7 -1.2 -0.7 -1.5
Irritability 1.8 3.0 15.0 -1.5 -1.7 -1.6 -1.4 -1.3 -3.9 -0.3 1.7 0.6 0.5
Risk taking 0.9 1.4 8.9 0.4 -1.0 -1.0 -0.7 -0.5 -3.0 -0.4 0.5 0.1 -1.1
Ever had prostate specific antigen (PSA) test 2.7 3.1 6.8 1.9 0.9 1.9 1.9 2.0 -2.0 2.0 2.6 0.5 0.9
Fractured/broken bones in last 5 years 1.2 1.6 3.0 -1.3 -0.5 -1.5 -1.1 -1.1 -1.7 -1.3 -1.0 -1.1 -1.5
Age started oral contraceptive pill 0.6 0.8 3.4 -1.9 -0.8 0.3 -1.2 -0.8 -0.5 -1.0 0.4 -0.3 0.6
Diastolic blood pressure, automated reading 0.5 1.6 12.9 0.1 -0.1 0.2 -0.1 -0.0 3.6 -0.3 1.4 -0.8 -0.5
Ever depressed for a whole week 0.8 0.9 5.7 1.1 0.1 -0.0 0.7 0.8 0.3 0.9 2.4 0.5 0.5
Unable to work because of sickness or disability 0.9 1.2 4.4 0.6 1.2 -0.4 1.0 0.6 0.8 1.2 -1.4 2.1 0.6
Commuting to job workplace: Cycle 0.4 0.4 2.5 1.0 -0.4 -0.1 -0.3 0.0 -1.6 0.6 -0.3 -0.0 0.3
Myopia 0.7 1.0 2.1 -0.6 -0.6 -1.1 -1.2 -1.0 1.3 -0.9 -0.1 -1.0 -1.5
Vascular/heart problems diagnosed by doctor 0.1 0.4 1.3 1.1 0.3 0.1 -0.5 0.3 0.8 0.6 -1.1 0.5 0.0
Cholesterol lowering medication 1.0 1.5 3.6 -1.9 -0.9 -1.1 -0.9 -1.2 1.4 -1.4 0.9 -1.0 -1.3
Medication: Omeprazole (e.g. Zanprol) 1.7 2.0 5.8 -2.4 -1.2 -1.4 -2.0 -1.8 -0.2 -1.6 0.5 -0.2 -1.1
Pain experienced in last month 0.2 0.3 2.2 0.3 0.1 0.2 -0.3 -0.3 0.0 -0.5 -1.5 -0.2 0.2
Supplements: Calcium 0.3 0.3 1.6 -0.2 0.7 0.7 0.5 0.3 -0.5 -0.1 0.0 1.3 0.2
Basal cell carcinoma (self-reported) 0.3 0.3 1.2 1.1 -0.1 0.5 0.5 0.4 0.8 -0.0 0.1 -0.0 0.9
Heart attack/myocardial infarction (self-reported) 0.5 0.7 1.1 -0.9 -0.8 -0.3 -0.7 -1.1 -1.0 -0.9 0.8 -0.7 0.5
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.6 -0.6 0.9 1.3 0.1 0.6 -0.3 0.8 0.4 -0.0 0.8
Heart disease (siblings) 1.2 1.5 3.3 -1.5 -0.4 -0.8 -1.0 -1.0 1.0 -1.1 1.5 -1.3 -1.8
Alcohol drinker status: Previous 0.4 0.5 2.9 -1.7 -0.3 -0.7 -0.3 -0.4 -0.2 -0.1 -0.7 -0.5 -0.3
Pack years of smoking 3.8 5.6 11.7 0.0 1.6 1.6 2.5 2.5 1.8 3.4 -1.5 3.0 3.4
Impedance of whole body 0.5 2.8 15.6 1.1 -0.5 1.3 0.4 1.0 -3.9 1.3 0.5 1.0 2.1
Leg fat mass (left) 0.9 3.3 9.2 -2.5 -1.3 -1.4 -1.1 -1.3 2.4 -1.3 3.0 0.3 -1.9
Arm predicted mass (left) 0.4 2.1 6.9 -2.2 -0.3 -1.4 -0.5 -0.8 2.6 -1.0 0.7 -0.5 -2.2