TWAS hub - CACNA2D4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1400	0.0440	1.1e-03	0.048	NA	0.076	NA	0.092	8.7e-05	NA	8.7e-07	NA	6.0e-08
2	GTEx	Brain Caudate basal ganglia	0.4500	0.1010	3.6e-05	0.187	NA	0.174	NA	0.168	4.8e-06	NA	1.0e-05	NA	1.5e-05
3	GTEx	Breast Mammary Tissue (Female)	0.1145	0.0740	1.0e-01	0.007	NA	-0.010	NA	-0.010	1.9e-01	NA	9.0e-01	NA	8.5e-01
4	GTEx	Colon Sigmoid	0.3590	0.0980	1.4e-03	0.111	NA	0.075	NA	0.108	9.9e-05	NA	1.3e-03	NA	1.2e-04
5	GTEx	Nerve Tibial	0.3581	0.0563	1.0e-12	0.200	NA	0.232	NA	0.262	3.6e-14	NA	2.0e-16	NA	1.1e-18
6	GTEx	Testis	0.1930	0.0760	7.3e-03	0.042	NA	-0.004	NA	0.012	6.1e-03	NA	5.8e-01	NA	9.2e-02
7	GTEx	Thyroid	0.1720	0.0510	3.3e-04	0.063	NA	0.065	NA	0.070	1.4e-05	NA	1.0e-05	NA	4.7e-06
8	METSIM	Adipose	0.0657	0.0251	3.2e-03	-0.001	0.016	0.007	0.017	0.005	4.3e-01	0.00140	2.4e-02	0.0012	5.8e-02
9	TCGA	Prostate Adenocarcinoma	0.0541	0.0264	8.6e-03	0.008	0.028	0.010	NA	0.022	4.4e-02	0.00060	2.5e-02	NA	2.3e-03
10	TCGA	Thyroid Carcinoma	0.0810	0.0330	5.0e-04	0.053	0.030	0.027	NA	0.044	7.0e-06	0.00058	1.1e-03	NA	3.6e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Length of working week for main job	5.8	6.4	13.5	-2.0	-2.4	-3.7	-2.8	-3.2	-0.7	-2.8	0.0	-2.2	-3.0
Bipolar Disorder or Schizophrenia	5.5	13.3	70.2	-2.4	-1.4	-2.6	-1.8	-1.7	-8.4	-1.6	5.0	-1.4	-3.5
Schizophrenia (2014)	4.9	10.7	56.8	-2.9	-1.6	-3.0	-1.9	-2.2	-7.5	-1.9	2.9	-1.3	-2.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	4.7	5.6	11.8	-1.8	-3.0	-2.9	-2.7	-2.7	0.2	-3.4	-0.6	-1.9	-2.3
Commuting to job workplace: Walk	4.2	4.6	7.7	2.8	2.4	2.7	2.5	2.5	-0.7	2.0	-0.8	2.0	2.0
Multivitamins +/- minerals	3.9	5.0	7.4	-2.5	-2.7	-2.7	-2.4	-2.3	0.3	-1.9	1.9	-2.3	-2.3
Schizophrenia (2018)	3.8	7.9	38.7	-2.0	-1.4	-2.7	-1.8	-1.8	-6.2	-1.6	2.7	-1.2	-3.1
Pack years of smoking	3.8	5.6	11.7	0.0	1.6	1.6	2.5	2.5	1.8	3.4	-1.5	3.0	3.4
Bipolar Disorder (2018)	3.7	5.9	31.5	-1.3	-0.5	-0.8	-0.7	-0.5	-5.6	-0.5	4.5	-0.7	-1.8
Pack years adult smoking proportion	3.6	5.5	11.2	-0.1	1.5	1.4	2.5	2.4	2.4	3.3	-1.9	2.9	3.1
Chronic bronchitis/emphysema (father)	3.6	4.3	10.2	-2.8	-3.2	-2.6	-2.7	-2.6	0.3	-1.6	-0.2	-0.3	1.0
Ever highly irritable/argumentative for 2 days	3.5	4.2	9.2	2.2	2.7	2.9	3.0	2.8	0.4	1.9	0.2	0.4	0.5
Alcohol usually taken with meals	3.4	5.5	11.5	1.8	1.8	3.0	2.6	2.5	-1.5	3.0	-0.8	1.9	3.4
Had major operations	3.3	3.9	8.8	-2.2	-1.2	-2.7	-1.5	-2.0	0.3	-2.1	-0.5	-2.4	-3.0
Ever used hormone-replacement therapy (HRT)	3.1	4.0	7.1	-2.7	-2.3	-2.1	-2.0	-2.2	-0.9	-2.4	1.5	-0.9	-2.2
Medication: Aspirin	3.1	4.1	8.2	-2.9	-2.1	-1.6	-1.5	-2.1	-2.3	-1.8	2.3	-1.7	-1.4
Eye problems/disorders: Glaucoma	3.1	3.7	6.1	2.3	2.0	2.5	2.4	2.3	-0.1	1.8	2.3	1.3	-0.3
Tinnitus: Yes, now most or all of the time	2.9	3.4	7.1	-1.5	-1.2	-2.0	-2.5	-2.6	0.2	-2.7	-0.2	-1.2	-2.2
Illnesses of father: High blood pressure	2.8	3.5	6.4	-1.8	-2.3	-2.5	-2.1	-2.3	-1.1	-1.8	1.6	-1.2	-1.2
Ever had prostate specific antigen (PSA) test	2.7	3.1	6.8	1.9	0.9	1.9	1.9	2.0	-2.0	2.0	2.6	0.5	0.9
Tense / ‘highly strung’	2.6	4.3	19.5	-1.9	-1.9	-2.2	-1.7	-2.0	-4.4	-1.2	1.5	-0.2	0.6
Average weekly beer plus cider intake	2.6	3.7	8.6	-2.5	-2.0	-2.9	-2.5	-2.2	0.0	-1.7	-1.2	-0.7	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	2.4	3.6	8.7	-2.0	-2.2	-3.0	-1.8	-2.4	-1.9	-2.0	0.9	-0.9	-0.2
Bipolar Disorder (2011)	2.3	2.3	17.7	-0.7	0.0	0.2	0.0	-0.1	-4.2	-0.5	1.5	-1.1	-0.9
Relative age voice broke	2.3	3.5	8.3	2.6	2.3	2.9	1.8	2.2	-1.6	1.0	-0.5	1.6	-0.0
Medication: Aspirin	2.3	3.0	6.2	-2.5	-1.8	-1.3	-1.2	-1.8	-2.1	-1.5	2.1	-1.7	-0.7
Other serious medical condition/disability diagnosed by doctor	2.1	2.8	5.3	-2.0	-1.1	-2.3	-2.2	-2.3	-1.3	-1.8	0.3	-0.9	-1.2
Glaucoma (self-reported)	2.1	2.5	5.8	2.4	1.5	1.8	1.8	1.7	-0.1	1.1	2.3	0.7	-0.6
Qualifications: NVQ or HND or HNC or equivalent	2.1	2.5	6.1	2.5	1.8	1.7	1.8	1.7	0.3	1.2	-2.2	0.3	0.0
Average weekly red wine intake	2.1	3.1	5.6	1.1	1.4	2.3	2.1	2.4	-2.0	2.1	0.3	0.8	1.8
Ulcerative Colitis	2.0	2.9	7.5	1.3	2.7	1.8	2.0	2.2	-1.3	1.9	0.2	0.9	0.9
Medication: Omeprazole	2.0	2.4	5.9	-2.4	-1.2	-1.5	-2.0	-2.0	-0.8	-1.9	1.1	-0.4	-1.2
Commuting to job workplace: Public transport	2.0	2.4	7.2	1.8	2.7	2.1	1.3	1.7	0.2	1.5	-1.4	0.4	-0.2
Number of operations (self-reported)	2.0	2.9	7.9	-1.9	-0.7	-1.9	-1.2	-1.5	-0.1	-2.0	-0.4	-2.4	-2.8
Relative age of first facial hair	1.9	3.9	9.8	2.5	2.3	3.1	2.1	2.4	-0.5	1.8	-1.0	0.9	1.4
Depression (self-reported)	1.9	2.3	5.9	-1.7	-0.8	-1.9	-1.1	-1.6	0.7	-1.8	0.7	-1.4	-2.4
Mouth/teeth dental problems: Loose teeth	1.9	2.2	5.7	-1.6	-1.8	-1.9	-1.2	-1.5	-0.3	-0.9	2.4	-0.7	-1.3
Medication: Seretide 50 evohaler	1.9	2.2	4.5	-1.3	-1.7	-1.9	-1.3	-1.4	-2.1	-1.0	1.8	-1.2	0.8
Neuroticism (Nagel 2018)	1.8	4.1	8.2	-2.0	-1.6	-2.6	-2.5	-2.9	-2.5	-2.5	0.4	-1.1	-0.5
Medication for hormone replacement therapy	1.8	2.0	4.3	-0.6	-2.1	-1.6	-1.0	-1.4	-2.1	-1.5	1.0	-0.8	-1.3
Irritability	1.8	3.0	15.0	-1.5	-1.7	-1.6	-1.4	-1.3	-3.9	-0.3	1.7	0.6	0.5
Worry (Nagel 2018)	1.7	3.6	15.1	-1.2	-1.3	-2.2	-1.8	-2.1	-3.9	-2.0	0.5	-0.9	-0.1
Number of treatments/medications taken	1.7	3.0	9.9	-3.1	-0.8	-1.4	-1.1	-1.5	-0.6	-1.5	2.4	-0.8	-2.3
Birth weight	1.7	3.6	7.5	-2.6	-2.6	-1.5	-2.7	-2.4	-0.7	-2.2	-0.1	-1.1	0.2
Medication: Omeprazole (e.g. Zanprol)	1.7	2.0	5.8	-2.4	-1.2	-1.4	-2.0	-1.8	-0.2	-1.6	0.5	-0.2	-1.1
Eye problems/disorders: None of the above	1.6	1.8	2.8	-0.7	-1.7	-1.5	-1.7	-1.4	0.4	-1.5	-0.7	-1.6	-1.6
Commuting to job workplace: Car/motor vehicle	1.6	1.9	3.8	-1.0	-1.7	-1.7	-1.3	-1.4	-0.8	-1.6	2.0	-0.8	-0.8
Vitamin and mineral supplements	1.5	2.1	3.7	1.5	1.7	1.3	1.4	1.4	0.2	1.4	-0.9	1.9	1.9
Age when periods started (menarche)	1.5	3.5	7.8	1.1	2.3	1.3	1.7	1.8	-2.8	2.1	-1.0	1.2	2.6
Fluid intelligence score	1.5	3.2	6.6	2.3	2.6	2.3	1.4	1.7	-0.4	1.4	-0.8	2.2	1.4
Prospective memory result	1.5	1.9	4.9	-0.9	-1.9	-2.2	-1.1	-1.6	-1.6	-0.9	0.6	-1.0	-1.0
Birth weight of first child	1.5	2.7	4.3	-1.2	-1.9	-1.8	-2.0	-2.1	1.4	-1.9	1.5	-1.2	-1.2
Number of children fathered	1.5	1.7	4.7	0.9	1.4	1.2	1.0	1.3	-1.1	1.3	0.1	1.8	2.2
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	6.6	0.1	0.7	1.2	1.1	1.4	-2.6	1.4	0.3	1.7	0.9
Depression (Nagel 2018)	1.4	2.0	6.4	-2.5	-1.0	-1.8	-1.8	-1.6	-0.3	-1.4	0.3	-1.2	-0.4
Alzheimer’s Disease (including proxy)	1.4	2.0	3.9	-1.1	-1.4	-2.0	-1.6	-2.0	-1.0	-1.9	1.0	0.3	-1.1
HbA1C	1.4	1.5	4.2	1.0	0.8	0.9	1.3	1.2	1.5	1.9	0.0	2.0	0.0
Medication: Gliclazide	1.4	1.6	5.6	-2.4	-1.6	-1.7	-1.1	-1.4	0.2	-0.7	1.0	-0.7	0.1
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.2	7.1	-1.1	-1.6	-2.7	-1.5	-1.7	1.6	-0.9	1.0	0.2	-1.1
Alcohol intake frequency.	1.3	2.9	6.4	-2.5	-0.8	-1.7	-1.4	-1.7	1.5	-1.7	-2.4	-1.4	-1.4
Suffer from ‘nerves’	1.3	2.0	3.7	-1.8	-1.2	-1.9	-1.4	-1.8	-1.0	-1.7	-0.6	-1.3	-1.0
Supplements: Vitamin C	1.3	1.5	5.1	-1.5	-0.5	-0.2	-1.3	-1.0	-1.3	-1.6	-0.1	-1.0	-2.3
Qualifications: nursing, teaching	1.3	2.0	10.2	0.1	-0.1	1.6	-0.3	0.4	-1.8	0.4	-1.8	0.1	3.2
Illnesses of father: None of the above (group 1)	1.3	1.6	6.4	0.7	1.9	1.6	1.0	1.0	0.3	0.4	-2.5	0.2	-0.1
Financial situation satisfaction	1.3	1.6	9.1	-1.3	-0.5	-1.0	-0.4	-0.7	3.0	-0.9	-0.5	-1.3	-0.6
Medication: Paracetamol	1.3	2.1	6.2	-0.9	-1.2	-1.5	-1.0	-1.3	0.1	-1.2	2.5	-1.5	-1.9
Angina	1.2	1.6	4.8	-2.2	-1.2	-1.5	-0.7	-0.9	-0.2	-0.8	1.9	-0.4	-1.2
Number of incorrect matches in round	1.2	1.9	6.4	-1.3	-2.1	-1.4	-1.3	-1.3	-2.5	-0.9	0.9	0.4	0.1
Qualifications: None of the above	1.2	2.6	8.0	-1.9	-2.3	-2.8	-1.3	-2.0	1.1	-1.3	0.8	-0.0	-0.6
Time employed in main current job	1.2	1.4	11.2	1.1	0.7	0.2	0.1	0.2	3.3	0.2	-0.7	0.3	-0.2
Pulse rate	1.2	2.0	9.4	0.1	-1.5	-1.0	-1.0	-1.1	3.1	-1.0	-1.2	-1.4	-0.8
Illnesses of mother	1.2	1.4	3.3	1.1	1.8	1.8	1.2	1.5	-1.0	1.1	-0.7	0.6	0.3
Emphysema/chronic bronchitis	1.2	1.4	3.1	-1.4	-1.3	-1.2	-0.6	-1.0	-1.8	-0.7	-0.9	-1.7	-0.1
Migraine (self-reported)	1.2	1.5	2.8	0.7	1.5	1.2	1.5	1.7	-0.1	1.6	-0.4	1.5	0.6
Pulse rate, automated reading	1.2	3.9	8.7	-2.1	-1.1	-1.7	-1.7	-1.7	2.9	-2.0	-1.7	-2.0	-2.3
Overall health rating	1.2	2.7	9.2	-2.3	-1.3	-2.1	-1.1	-1.5	3.0	-1.0	0.1	-1.1	-0.1
Loneliness, isolation	1.2	1.6	3.1	-1.5	-1.7	-1.8	-1.7	-1.7	0.2	-1.3	-0.2	0.2	-0.7
Ever had bowel cancer screening	1.2	1.4	4.1	-1.1	-0.7	-0.6	-1.3	-1.3	-1.6	-1.4	0.6	-2.0	-0.3
Ever taken oral contraceptive pill	1.2	1.3	4.2	-1.1	0.5	-0.1	0.0	0.1	1.9	-0.3	-2.0	-1.6	-1.2
Medication: Atorvastatin	1.2	1.5	2.8	-1.6	-1.7	-0.9	-1.2	-1.2	0.7	-1.1	0.4	-1.0	-1.6
Alcohol drinker status: Never	1.2	1.4	3.0	-1.2	-1.3	-0.9	-1.7	-1.7	-0.3	-1.4	-1.5	0.0	0.0
Fractured/broken bones in last 5 years	1.2	1.6	3.0	-1.3	-0.5	-1.5	-1.1	-1.1	-1.7	-1.3	-1.0	-1.1	-1.5
Heart disease (siblings)	1.2	1.5	3.3	-1.5	-0.4	-0.8	-1.0	-1.0	1.0	-1.1	1.5	-1.3	-1.8
Alzheimer’s Disease (in father)	1.1	1.2	2.4	-1.0	-1.3	-1.4	-1.1	-1.2	0.1	-1.1	1.6	0.5	0.7
Ovarian Cancer	1.1	1.5	2.9	-1.0	-1.1	-1.5	-1.7	-1.6	-0.8	-1.4	-1.3	-1.0	0.5
Nervous feelings	1.1	2.1	9.6	-1.3	-1.1	-1.0	-1.1	-1.2	-3.1	-1.3	1.1	-1.0	-0.5
Hair/balding pattern: Pattern 2	1.1	1.3	3.4	1.1	1.8	1.4	1.1	1.3	-0.9	1.5	-0.5	-0.2	0.8
Worrier / anxious feelings	1.1	2.0	18.4	0.3	-0.2	-0.9	-0.3	-0.4	-4.3	-0.4	0.3	0.2	-0.0
Exposure to tobacco smoke outside home	1.1	1.4	2.7	0.8	1.4	1.6	1.3	1.2	1.6	1.1	1.0	-0.1	0.7
Angina (self-reported)	1.1	1.5	5.4	-2.3	-1.1	-1.3	-0.7	-0.9	-0.3	-0.8	1.8	-0.2	-1.1
Breast cancer (self-reported)	1.1	1.3	2.8	1.6	1.2	1.7	1.4	1.5	-0.3	0.9	1.0	0.5	-0.1
Mean Putamen Volume	1.0	1.2	4.0	1.1	1.0	0.7	0.7	0.7	-0.1	1.0	0.3	1.8	2.0
Neuroticism (2016)	1.0	1.4	6.8	-0.9	-0.8	-0.9	-1.2	-1.4	-2.6	-1.1	0.6	-0.1	0.1
Tinnitus: Yes, but not now, but have in the past	1.0	1.0	2.2	0.5	1.4	0.7	1.5	1.2	-0.9	1.4	0.0	0.1	1.1
Illnesses of siblings	1.0	1.4	9.5	0.0	-0.8	-0.9	-1.4	-0.9	-0.3	-0.3	-3.1	-0.1	0.2
Father’s age at death	1.0	1.3	4.5	2.1	0.5	0.9	0.4	0.7	-1.3	1.1	0.6	0.7	1.9
Hair/balding pattern: Pattern 3	1.0	1.4	3.8	-1.9	-1.3	-0.9	-0.6	-1.1	-0.4	-1.4	0.6	-1.8	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	2.9	-1.7	-0.3	-0.6	-1.2	-1.0	-0.6	-1.3	0.5	-1.0	-1.5
Average weekly champagne plus white wine intake	1.0	1.4	4.5	1.4	0.8	2.1	0.7	0.8	-0.6	0.7	1.8	0.8	0.6
Cholesterol lowering medication	1.0	1.5	3.6	-1.9	-0.9	-1.1	-0.9	-1.2	1.4	-1.4	0.9	-1.0	-1.3
Sensitivity / hurt feelings	0.9	1.6	3.2	-1.0	-1.1	-1.8	-1.4	-1.7	-1.2	-1.3	-0.9	-1.3	0.1
Hearing difficulty/problems with background noise	0.9	1.4	3.2	-1.0	-0.8	-1.4	-1.3	-1.3	-0.3	-1.3	1.8	-0.8	-1.3
Falls in the last year	0.9	1.2	2.4	1.2	0.7	0.9	0.8	0.9	-1.6	1.2	-0.8	1.1	1.5
Medication: Ventolin 100micrograms inhaler	0.9	1.2	2.8	0.3	1.1	0.4	1.6	1.3	-1.7	1.3	-0.2	-1.0	0.3
High blood pressure (siblings)	0.9	1.3	6.7	0.4	0.0	1.2	0.7	0.6	-0.1	0.4	2.6	1.2	1.4
Body fat percentage	0.9	3.4	12.4	-2.7	-1.8	-1.1	-1.4	-1.4	1.5	-1.3	3.5	0.4	-1.4
Number of full brothers	0.9	1.1	2.6	0.8	1.3	0.3	1.6	1.2	1.5	1.4	0.4	0.3	0.6
Worry too long after embarrassment	0.9	1.5	3.8	-1.0	-1.0	-1.4	-1.1	-1.2	-1.9	-0.8	1.9	-0.6	-0.4
Medication for pain relief, constipation, heartburn	0.9	1.6	5.2	2.3	1.0	1.1	0.9	1.2	1.2	0.7	-2.0	-0.0	0.5
Whole body fat mass	0.9	3.8	9.5	-3.0	-1.7	-1.5	-1.6	-1.6	1.9	-1.5	3.1	0.2	-2.0
Illnesses of father: Heart disease	0.9	1.3	3.6	-0.8	-1.1	-1.7	-0.4	-0.7	0.4	-0.4	1.9	-1.8	-0.9
Risk taking	0.9	1.4	8.9	0.4	-1.0	-1.0	-0.7	-0.5	-3.0	-0.4	0.5	0.1	-1.1
Unable to work because of sickness or disability	0.9	1.2	4.4	0.6	1.2	-0.4	1.0	0.6	0.8	1.2	-1.4	2.1	0.6
Leg fat mass (left)	0.9	3.3	9.2	-2.5	-1.3	-1.4	-1.1	-1.3	2.4	-1.3	3.0	0.3	-1.9
Allergy or Eczema	0.8	2.2	3.7	-0.8	-1.3	-1.5	-1.5	-1.7	1.6	-1.9	-1.0	-1.5	-1.5
Neuroticism	0.8	1.9	8.2	-1.1	-0.7	-1.4	-1.2	-1.8	-2.9	-1.6	0.5	-0.4	-0.4
Frequency of depressed mood in last 2 weeks	0.8	1.2	4.9	-2.2	-0.4	-1.1	-0.7	-0.7	-1.6	-0.4	1.0	-0.7	-0.3
Trunk fat percentage	0.8	3.3	12.7	-2.8	-1.8	-0.9	-1.4	-1.4	1.0	-1.1	3.6	0.3	-1.3
Average weekly fortified wine intake	0.8	0.9	1.6	0.1	1.1	1.3	0.9	1.0	-1.1	1.3	-0.3	0.5	1.1
Qualifications: CSEs or equivalent	0.8	1.1	6.8	-0.6	0.5	-0.1	0.9	0.4	2.6	0.5	1.1	-1.0	0.3
Body mass index (BMI)	0.8	3.4	11.8	-2.5	-0.7	-1.1	-1.1	-1.3	3.4	-1.6	2.1	-0.3	-2.2
Trunk fat mass	0.8	3.3	10.6	-2.9	-1.6	-1.2	-1.4	-1.3	1.4	-1.1	3.2	0.4	-1.7
Past tobacco smoking	0.8	1.4	5.3	1.3	1.3	0.6	1.3	1.1	2.3	0.6	-1.1	-0.1	0.9
Had other major operations	0.8	1.0	2.2	1.3	0.8	1.5	1.4	1.4	0.6	0.8	0.8	0.2	-0.1
Financial difficulties in last 2 years	0.8	1.1	3.4	-0.9	0.4	-0.7	-0.7	-0.7	1.9	-1.0	-1.1	-0.7	-1.4
Arm fat percentage (right)	0.8	3.3	8.0	-2.2	-1.4	-1.1	-1.6	-1.6	2.2	-1.5	2.8	-0.4	-2.1
Hip circumference	0.8	3.6	7.5	-2.7	-1.2	-1.4	-1.2	-1.3	2.6	-1.4	2.7	-0.6	-2.2
Mouth/teeth dental problems: Dentures	0.8	1.3	6.4	-1.3	-0.9	-0.9	-0.7	-1.0	0.3	-0.7	-2.5	-0.1	0.9
Arm fat mass (right)	0.8	3.4	6.6	-2.6	-1.4	-1.4	-1.6	-1.6	2.6	-1.5	2.3	-0.2	-2.1
Leg fat percentage (right)	0.8	2.8	14.0	-1.9	-1.1	-0.7	-0.6	-0.7	2.2	-1.0	3.7	0.7	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	8.2	-0.3	-0.1	-1.0	0.2	-0.4	-2.9	-0.4	0.4	-0.7	-0.3
Leg fat mass (right)	0.8	3.1	8.2	-2.4	-1.1	-1.3	-1.0	-1.2	2.5	-1.2	2.9	0.5	-1.8
Illnesses of siblings: Diabetes	0.8	1.0	2.1	0.8	1.0	0.2	1.4	1.2	1.0	1.0	1.4	0.8	0.2
Wears glasses or contact lenses	0.8	1.0	4.7	-1.2	-0.6	-0.9	0.2	-0.3	2.2	-0.1	-0.3	-1.4	-0.0
Pain type(s) experienced in last month: Hip pain	0.8	1.1	2.0	-0.7	-0.4	-1.1	-1.0	-1.4	1.1	-1.1	-1.4	-1.0	-0.4
Leg fat percentage (left)	0.8	2.9	15.3	-2.0	-1.2	-0.8	-0.7	-0.9	1.9	-1.1	3.9	0.5	-1.2
Ever depressed for a whole week	0.8	0.9	5.7	1.1	0.1	-0.0	0.7	0.8	0.3	0.9	2.4	0.5	0.5
Coronary Artery Disease (CAD)	0.7	0.9	2.3	0.1	0.7	0.0	0.3	-0.4	-1.2	-1.1	1.1	-1.5	-1.5
Fasting Glucose	0.7	0.8	2.3	-0.8	-0.4	-1.0	-0.4	-0.7	-0.9	-0.4	1.5	1.3	-1.0
Primary Biliary Cirrhosis	0.7	1.0	2.8	-0.1	1.1	1.0	1.1	1.1	-1.4	0.8	-0.7	0.0	1.7
Rheumatoid Arthritis	0.7	1.0	2.6	0.7	1.6	0.8	1.3	0.9	-0.3	0.8	-1.5	0.1	0.5
Respiratory disease	0.7	1.5	3.6	-1.5	-1.0	-1.4	-0.9	-0.9	-0.7	-0.8	-1.9	-1.5	-1.0
Chronotype (morning person)	0.7	1.5	6.2	-0.3	0.9	0.9	1.0	0.8	1.1	1.0	-1.6	0.8	2.5
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.2	1.0	1.1	0.5	1.0	1.1	1.5	0.6	-0.3	0.2	-0.9
Hayfever, allergic rhinitis or eczema	0.7	1.5	3.7	-0.6	-0.5	-1.2	-0.7	-1.0	1.9	-1.4	-1.2	-1.4	-1.6
Had menopause	0.7	0.9	4.3	-2.1	-1.1	-0.6	-0.9	-1.0	-0.0	-0.8	-0.2	0.0	0.7
Neuroticism score	0.7	1.4	5.5	-0.8	-0.6	-1.2	-1.0	-1.5	-2.3	-1.5	0.0	-0.6	-0.6
Blood clot in the leg (DVT)	0.7	0.9	2.5	-0.1	1.4	1.6	0.5	1.1	-0.2	1.3	0.4	0.2	0.8
Medication: Paracetamol	0.7	1.1	5.1	-0.5	-0.8	-0.9	-0.7	-0.9	0.6	-0.7	2.3	-0.9	-1.2
Medication: Ibuprofen	0.7	0.9	1.6	-1.0	-0.5	-1.0	-1.1	-1.1	-0.0	-1.2	0.7	-0.7	-1.3
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.8	-0.3	-1.3	-1.3	-1.0	-1.3	-1.0	-0.9	-0.1	-0.9	0.2
Arm fat percentage (left)	0.7	2.7	7.7	-2.0	-1.1	-0.8	-1.2	-1.2	2.3	-1.2	2.8	-0.0	-1.8
Back pain experienced in last month	0.7	1.0	5.3	-2.3	-0.8	-1.1	-1.0	-1.0	-0.3	-0.4	-0.3	-0.7	0.8
Mineral and other dietary supplements	0.7	0.9	2.8	0.4	0.3	0.2	0.8	0.7	0.9	1.0	-0.4	1.7	1.7
Arm fat mass (left)	0.7	3.0	8.3	-2.3	-1.1	-1.1	-1.1	-1.1	2.9	-1.1	2.6	0.2	-1.9
Myopia	0.7	1.0	2.1	-0.6	-0.6	-1.1	-1.2	-1.0	1.3	-0.9	-0.1	-1.0	-1.5
Depressed Affect (Nagel 2018)	0.6	1.2	3.0	-1.2	-0.3	-1.3	-1.3	-1.7	0.1	-1.7	-0.1	-0.4	-0.8
Heel T-Score	0.6	4.5	28.3	-1.1	-2.1	-0.5	-0.9	-0.8	2.1	-1.0	5.3	-1.6	-1.3
Waist Hip Ratio (WHR)	0.6	2.8	11.0	1.3	1.8	0.7	1.4	1.1	-3.3	1.6	-1.1	1.4	1.6
Maternal smoking around birth	0.6	0.8	2.8	-0.2	0.0	-0.2	1.4	0.7	-0.5	1.2	0.6	0.6	1.7
Fed-up feelings	0.6	1.1	3.2	-1.1	-0.6	-1.3	-0.7	-1.4	1.8	-1.1	-0.0	-0.5	-0.6
Stomach or abdominal pain in last month	0.6	0.8	2.2	-0.8	1.1	0.4	1.0	0.9	1.0	1.5	-0.4	0.5	0.4
Impedance of leg (left)	0.6	2.8	14.8	0.9	-0.6	1.1	0.8	1.0	-3.8	1.3	1.0	0.9	2.4
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.9	0.4	0.6	-0.7	0.8	0.4	1.2	-0.2	1.0	-0.5	-1.7
Pain all over the body in last month	0.6	0.6	1.6	0.8	0.9	0.8	1.3	0.9	0.4	0.7	0.5	0.4	0.7
Impedance of arm (left)	0.6	2.6	12.1	1.5	0.1	1.5	0.5	1.2	-3.5	1.7	-0.1	1.1	1.9
Loud music exposure frequency	0.6	0.7	4.2	1.2	0.8	0.1	0.1	-0.1	-0.1	-0.4	0.2	-0.7	-2.1
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.5	-1.3	-0.6	-0.2	-1.6	-0.8	-1.1	-0.7	-1.0	-1.0	1.2
Gout (self-reported)	0.6	0.8	3.3	0.0	-0.3	-1.1	-0.5	-0.8	-1.1	-0.9	-1.8	0.3	-0.5
Comparative body size at age 10	0.6	1.6	11.0	-0.1	-0.9	-1.0	-0.8	-0.5	3.3	-0.6	0.4	-0.7	-1.3
Qualifications: College or University degree	0.6	1.9	5.8	1.7	1.4	2.4	0.4	1.2	-2.1	0.8	-0.4	-0.1	1.0
Medication: Allopurinol	0.6	0.8	2.3	0.3	-0.8	-1.5	-0.4	-1.0	-1.1	-1.2	-0.1	0.4	-1.2
Comparative height size at age 10	0.6	3.1	8.4	-2.9	-2.5	-2.6	-2.1	-1.4	0.2	-0.6	0.1	-0.5	-1.8
Friendships satisfaction	0.6	0.7	2.8	-0.4	-1.3	-0.9	-0.7	-0.7	0.7	-0.3	1.7	-0.5	0.4
Supplements: Fish oil (including cod liver oil)	0.6	0.7	3.1	-0.4	0.1	-0.1	-0.6	-0.5	-0.7	-0.8	0.4	-1.5	-1.8
Age started oral contraceptive pill	0.6	0.8	3.4	-1.9	-0.8	0.3	-1.2	-0.8	-0.5	-1.0	0.4	-0.3	0.6
Schizophrenia vs Biploar Disorder	0.5	0.7	2.8	-1.2	-0.8	-1.7	-0.6	-1.1	-0.0	-0.6	-0.1	-0.6	-0.1
Major Depression (MDD)	0.5	0.6	1.6	-1.0	-0.6	-1.2	-0.6	-0.9	-0.9	-0.3	-0.6	-0.1	-0.3
Lupus	0.5	0.7	2.8	-1.7	-0.9	-0.6	-0.3	-0.5	-0.5	-0.4	0.8	1.2	0.3
Type 2 Diabetes (T2D) (2012)	0.5	0.6	2.6	0.5	1.0	0.6	0.4	0.6	-1.6	1.2	-0.1	0.4	0.4
BMI	0.5	2.7	8.4	-2.5	-0.3	-1.2	-0.1	-0.7	1.1	-1.1	2.9	0.8	-2.7
Average weekly spirits intake	0.5	0.6	1.2	-0.9	-0.7	-0.8	-0.4	-0.6	1.0	-1.0	0.5	0.1	-1.1
Ever had hysterectomy (womb removed)	0.5	0.6	3.1	-0.2	-0.5	-0.5	-0.4	-0.5	1.8	-1.0	-0.8	-0.3	-0.6
Systolic blood pressure, automated reading	0.5	1.3	3.8	-1.7	-0.9	-0.6	-0.7	-0.8	2.0	-0.7	1.7	-0.1	-1.0
Diabetes (father)	0.5	0.6	2.4	-0.7	-0.8	-0.9	-0.4	-0.2	-0.9	-0.0	1.1	-0.2	-1.5
Impedance of leg (right)	0.5	2.2	11.0	1.0	-0.5	1.0	0.8	1.1	-3.3	1.4	0.9	0.9	1.9
Hand grip strength (right)	0.5	1.3	2.7	1.4	0.6	1.1	1.3	1.6	-0.2	1.4	0.4	1.2	1.0
Taking other prescription medications	0.5	0.8	3.3	-1.4	-0.4	-0.8	0.4	-0.1	-0.1	0.6	1.8	1.0	-0.2
Medication: Levothyroxine sodium	0.5	0.9	2.8	0.3	1.1	0.7	1.1	0.8	0.6	0.6	1.7	0.9	0.9
High blood pressure (mother)	0.5	0.7	3.7	-0.1	-1.0	-0.8	-0.4	-0.8	0.9	-0.7	-0.1	-1.9	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	3.5	-0.1	0.9	1.6	0.8	1.4	1.9	1.0	1.1	-0.0	0.2
Allergy	0.5	1.1	2.4	1.1	-0.1	0.7	0.4	0.5	-1.4	0.9	1.4	1.6	1.2
Weight	0.5	2.3	6.4	-2.5	-0.7	-1.1	-1.0	-0.9	2.5	-0.9	1.5	0.0	-1.9
Number of live births	0.5	0.7	4.2	0.4	0.0	0.2	1.0	0.7	2.1	0.6	-0.3	-0.0	0.5
Happiness	0.5	0.6	1.3	-0.6	-0.7	-0.7	-0.5	-0.6	1.0	-0.6	1.1	-0.7	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	2.0	-0.9	0.4	0.5	0.7	0.9	0.9	0.8	0.0	1.4	0.6
Medication: Lansoprazole	0.5	0.6	4.7	0.5	-0.1	0.0	0.1	0.2	2.2	-0.1	-0.4	0.4	-0.9
Exposure to tobacco smoke at home	0.5	0.6	1.4	-0.4	-0.9	-0.4	-1.1	-1.2	-0.6	-1.2	0.4	-0.6	0.3
Headache pain in last month	0.5	0.8	5.3	-0.6	-0.2	-0.6	-0.3	-0.6	2.3	-0.5	-0.6	-0.7	-0.8
Age at first live birth	0.5	0.8	3.4	0.5	0.6	0.9	0.4	0.9	-1.9	0.5	-0.3	-0.1	1.4
Neck or shoulder pain in last month	0.5	0.7	2.7	-0.9	-0.4	-0.6	0.0	0.1	-1.6	0.1	0.9	1.3	0.4
Knee pain experienced in last month	0.5	0.8	5.7	0.5	-0.6	-0.3	0.2	-0.3	-0.3	-0.3	2.4	1.2	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	2.2	0.4	0.8	-0.3	1.0	0.5	1.5	0.9	-0.2	0.6	-0.4
Smoking status: Previous	0.5	0.7	4.3	-0.3	-0.8	-0.1	-0.6	-0.4	-2.1	0.1	0.9	0.6	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.3	-0.3	1.0	0.5	0.8	1.1	-0.8	1.1	-0.7	-0.2	-0.3
Smoking status: Current	0.5	0.7	1.2	-1.1	-0.6	-1.1	-1.0	-1.0	0.4	-0.6	-0.3	-0.9	-1.0
Guilty feelings	0.5	0.8	1.9	-0.1	0.9	0.7	-0.6	-0.5	-0.6	-1.2	-1.0	-1.0	-1.4
Hearing aid user	0.5	0.6	1.9	-0.5	-0.7	-0.4	-0.1	-0.5	-0.4	-0.9	1.4	-0.9	-0.9
Ever smoked	0.5	0.9	4.2	-1.5	-0.6	-0.1	-0.8	-0.5	-2.1	0.0	1.0	0.3	-0.5
Arm fat-free mass (left)	0.5	2.3	6.9	-2.3	-0.5	-1.4	-0.7	-1.0	2.6	-1.1	0.6	-0.4	-2.3
Diastolic blood pressure, automated reading	0.5	1.6	12.9	0.1	-0.1	0.2	-0.1	-0.0	3.6	-0.3	1.4	-0.8	-0.5
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.1	-0.9	-0.8	-0.3	-0.7	-1.1	-1.0	-0.9	0.8	-0.7	0.5
Impedance of whole body	0.5	2.8	15.6	1.1	-0.5	1.3	0.4	1.0	-3.9	1.3	0.5	1.0	2.1
Alzheimer’s Disease (in mother)	0.4	0.5	1.2	-0.2	-0.5	-1.1	-0.6	-0.8	-0.9	-0.3	0.8	0.3	-0.6
Ulcerative Colitis (UC)	0.4	0.7	2.1	0.7	1.5	0.4	1.0	1.0	-0.9	0.8	0.7	-0.1	0.2
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.4	0.9	1.6	0.7	0.6	0.5	0.3	0.5	-1.4	0.9	1.2
Age at First Birth	0.4	0.6	2.1	0.4	0.6	1.2	0.3	0.5	-1.3	0.1	-1.4	0.1	0.4
Body Mass Index (BMI) (2010)	0.4	0.6	1.8	-0.8	-0.0	-0.5	-0.4	-0.6	-1.4	-0.6	1.4	0.3	-0.6
Type 2 Diabetes (T2D) (2018)	0.4	0.8	3.3	-0.6	0.7	0.6	1.0	1.0	-0.3	1.1	-0.2	1.8	-0.3
Lung FVC	0.4	1.9	4.6	-0.6	-1.4	-1.4	-2.1	-2.1	-0.3	-1.7	-1.2	0.2	-0.9
Hand grip strength (left)	0.4	1.0	2.5	1.4	0.6	0.9	1.3	1.6	0.0	1.3	-0.4	0.3	0.8
Hearing difficulty/problems: Yes	0.4	0.6	2.2	-0.9	-0.2	-0.5	-0.1	-0.4	1.0	-0.4	0.8	-0.4	-1.5
Supplements: Zinc	0.4	0.5	1.7	-0.9	-0.9	-0.7	-0.5	-0.4	-0.3	-0.5	-0.0	-0.6	-1.3
Medication: Co-codamol	0.4	0.5	2.8	0.0	0.1	0.1	-0.7	0.0	1.7	-0.2	-0.2	-0.7	-0.8
Medication: Metformin	0.4	0.5	2.9	-0.1	-0.4	0.4	0.2	0.3	-0.5	0.9	0.4	1.7	0.9
Severe depression (siblings)	0.4	0.4	1.0	0.6	0.6	0.7	0.4	1.0	-0.9	1.0	-0.3	-0.1	0.5
Leg fat-free mass (left)	0.4	2.1	7.1	-2.1	-0.4	-1.5	-0.9	-0.9	2.7	-0.7	0.0	-0.1	-2.2
Serious illness, injury or assault to yourself	0.4	0.5	1.5	0.4	0.1	-0.8	-0.5	-0.5	-0.8	-0.5	-0.2	-1.2	-1.1
Medication: Atenolol	0.4	0.5	1.6	-0.8	0.1	-0.4	0.5	-0.1	-1.3	0.6	0.7	1.2	0.2
Leg predicted mass (left)	0.4	2.2	6.8	-2.2	-0.5	-1.6	-1.0	-1.0	2.6	-0.8	-0.0	-0.1	-2.2
Waist circumference	0.4	1.3	3.6	-1.9	-0.2	-0.9	-0.6	-0.8	1.6	-0.7	1.7	0.2	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.4	-1.0	-1.0	-1.1	-0.4	-0.7	-1.2	-0.4	0.3	0.3	0.1
Mouth/teeth dental problems	0.4	0.5	2.7	1.6	0.7	0.9	-0.1	0.4	-0.4	0.4	0.1	1.0	0.2
Heart attack	0.4	0.5	0.9	-0.8	-0.6	-0.2	-0.6	-1.0	-0.7	-0.9	0.6	-0.8	0.3
Impedance of arm (right)	0.4	1.8	12.3	1.0	-0.6	0.8	-0.6	0.1	-3.5	0.7	-0.6	0.5	1.4
Alcohol intake versus 10 years previously	0.4	0.6	3.0	-0.8	0.5	-0.5	0.5	0.1	0.9	-0.1	-1.1	0.2	-1.7
Qualifications: A levels/AS levels or equivalent	0.4	0.9	3.4	-0.7	-0.9	-0.3	-1.9	-1.3	0.6	-0.9	-0.7	-1.0	0.1
Lung cancer (father)	0.4	0.5	2.3	0.1	0.3	-0.2	0.6	0.8	0.5	1.5	-0.5	0.6	0.9
Breastfed as a baby	0.4	0.5	2.3	0.5	-0.1	0.7	0.2	0.3	-0.5	0.3	1.1	1.5	-0.5
Medication: Amlodipine	0.4	0.6	1.9	-1.3	-0.2	-0.4	-0.3	-0.6	-0.0	-1.0	0.1	-0.8	-1.4
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.4	-1.2	-0.8	-0.9	-0.4	-0.5	0.4	0.1	0.1	0.2	0.8
Arm fat-free mass (right)	0.4	1.8	5.7	-2.2	-0.2	-1.4	-0.2	-0.5	2.4	-0.6	0.7	-0.1	-2.1
Shortness of breath walking on level ground	0.4	0.4	1.6	-0.8	0.1	-0.3	-0.1	-0.6	-0.1	-0.8	1.3	1.0	-0.3
Mean time to correctly identify matches	0.4	0.7	2.8	-0.3	-0.6	-0.5	-0.8	-1.3	0.9	-0.5	-0.7	-1.7	0.5
Heart disease (mother)	0.4	0.5	2.7	-1.1	-0.4	-0.3	0.2	-0.1	-0.4	-0.2	1.6	0.7	-0.5
Arm predicted mass (right)	0.4	2.3	6.7	-2.5	-0.6	-1.8	-0.4	-0.8	2.6	-0.7	0.7	-0.3	-2.1
Chest pain or discomfort	0.4	0.6	2.8	-1.7	-0.3	-0.4	0.2	-0.2	1.3	0.3	0.8	0.8	0.1
Family relationship satisfaction	0.4	0.4	1.9	-0.2	0.1	0.1	0.4	0.3	-0.2	0.4	0.7	1.4	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.7	-0.7	0.2	-0.2	0.7	0.8	-1.6	0.9	-1.6	0.0	-0.0
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.8	0.4	-0.1	-0.7	0.5	0.2	0.2	0.3	-1.0	1.1	1.3
Long-standing illness, disability or infirmity	0.4	0.7	2.5	-1.6	-0.4	-0.8	-0.4	-0.6	0.8	-0.3	0.0	-0.6	-1.4
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	2.4	0.5	0.4	0.6	1.5	0.8	-0.3	1.0	1.1	0.3	-0.1
Mother’s age at death	0.4	0.5	1.8	1.0	-1.0	-0.0	-0.5	-0.3	0.0	-0.4	1.4	0.7	0.6
Basal metabolic rate	0.4	2.0	6.8	-2.1	-0.4	-1.5	-0.8	-0.9	2.6	-0.7	0.2	-0.3	-2.1
Commuting to job workplace: Cycle	0.4	0.4	2.5	1.0	-0.4	-0.1	-0.3	0.0	-1.6	0.6	-0.3	-0.0	0.3
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.6	-0.6	0.9	1.3	0.1	0.6	-0.3	0.8	0.4	-0.0	0.8
Alcohol drinker status: Previous	0.4	0.5	2.9	-1.7	-0.3	-0.7	-0.3	-0.4	-0.2	-0.1	-0.7	-0.5	-0.3
Arm predicted mass (left)	0.4	2.1	6.9	-2.2	-0.3	-1.4	-0.5	-0.8	2.6	-1.0	0.7	-0.5	-2.2
HDL Cholesterol	0.3	0.5	1.1	-0.2	-1.1	-0.9	-0.9	-0.6	0.6	-0.7	-0.9	-0.5	-0.3
Blood Platelet Count	0.3	3.1	10.6	-0.9	0.5	0.2	1.5	1.2	-1.4	1.4	-3.3	1.9	2.8
Blood White Count	0.3	1.9	4.8	-1.9	-1.3	-1.2	-0.8	-1.2	0.5	-1.1	-2.2	1.7	1.2
Systolic Blood Pressure	0.3	1.4	4.2	0.6	0.9	1.0	1.4	1.4	2.0	1.1	0.6	1.4	-0.2
Smoking Status	0.3	0.7	2.9	-0.7	-0.5	-0.4	-0.3	-0.1	-1.7	0.4	1.4	-0.3	-0.7
Hypothyroidism (self reported)	0.3	0.8	5.7	-0.0	-0.0	0.3	-0.3	-0.2	0.8	-0.5	2.4	0.6	-0.6
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.1	0.4	0.7	0.1	0.5	0.6	0.6	1.1	-0.1	0.6	0.2
Townsend deprivation index at recruitment	0.3	0.4	1.6	0.0	0.1	-0.0	0.5	0.1	0.5	-0.1	-0.9	-1.2	-1.3
Medication: Ramipril	0.3	0.4	1.4	-1.2	0.6	0.3	0.1	-0.1	-0.3	-0.5	-0.0	-0.9	-1.0
Medication: Simvastatin	0.3	0.4	2.1	-1.4	1.1	-0.0	0.1	-0.3	0.4	-0.5	-0.6	-0.2	-0.4
Trunk fat-free mass	0.3	1.7	5.5	-1.8	-0.2	-1.6	-0.7	-0.8	2.3	-0.7	-0.4	-0.5	-2.0
Noisy workplace	0.3	0.4	2.9	-0.0	0.3	0.2	-0.2	-0.2	-0.0	-0.4	-0.2	-1.7	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.1	-0.3	-0.1	-0.7	-0.6	-0.7	0.5	-1.0	0.2	-0.1	-0.9
Trunk predicted mass	0.3	1.7	5.7	-1.7	-0.1	-1.6	-0.6	-0.7	2.4	-0.6	-0.4	-0.5	-2.0
Peak expiratory flow (PEF)	0.3	0.7	2.1	0.9	-0.2	-0.4	-1.0	-0.6	-1.4	-0.8	-0.8	-1.0	-0.8
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.7	-1.3	-0.2	-0.3	0.1	0.2	0.6	-0.0	1.0	-0.5	-0.7
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	4.7	0.3	0.1	0.4	0.2	-0.0	0.3	-0.2	2.2	0.7	0.2
Pulse wave peak to peak time	0.3	0.4	1.4	0.3	1.1	-0.0	0.7	0.6	-1.2	0.5	-0.4	0.2	0.1
Medication: Blood pressure	0.3	0.4	1.4	-0.3	1.2	1.1	0.9	0.6	-0.4	0.3	0.3	0.5	0.0
Number of full sisters	0.3	0.3	0.9	0.2	0.7	0.4	0.6	0.9	0.2	0.9	0.3	-0.1	-0.6
Whole body fat-free mass	0.3	2.0	6.4	-2.0	-0.4	-1.6	-0.7	-0.9	2.5	-0.7	-0.2	-0.4	-2.1
Leg fat-free mass (right)	0.3	1.8	5.0	-2.1	-0.4	-1.5	-0.9	-1.0	2.2	-0.8	-0.2	-0.1	-2.0
Mood swings	0.3	0.5	2.8	-0.1	1.4	0.1	0.3	0.1	-1.7	-0.1	-0.4	-0.2	-0.5
Eye problems/disorders: Cataract	0.3	0.3	2.4	0.1	0.5	0.4	0.0	-0.2	-1.5	-0.2	0.2	-0.1	0.5
Whole body water mass	0.3	1.8	6.5	-1.9	-0.2	-1.4	-0.6	-0.7	2.6	-0.6	-0.2	-0.3	-2.1
Leg predicted mass (right)	0.3	1.8	5.0	-2.1	-0.3	-1.5	-0.9	-0.9	2.2	-0.8	-0.3	-0.2	-2.0
Number of self-reported non-cancer illnesses	0.3	0.5	2.2	-1.5	0.9	-0.1	0.4	0.1	-0.3	0.0	0.8	-0.3	-1.0
Supplements: Calcium	0.3	0.3	1.6	-0.2	0.7	0.7	0.5	0.3	-0.5	-0.1	0.0	1.3	0.2
Basal cell carcinoma (self-reported)	0.3	0.3	1.2	1.1	-0.1	0.5	0.5	0.4	0.8	-0.0	0.1	-0.0	0.9
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.8	0.6	1.2	0.8	0.2	0.1	1.3	0.1	-1.2	-0.0	0.6
Crohns Disease (2017)	0.2	0.4	1.2	-1.0	-0.4	-0.9	-0.3	-0.6	-0.3	-0.0	0.5	-1.1	0.1
Reaction Time	0.2	0.3	1.0	0.4	0.3	0.2	0.3	-0.2	0.6	0.5	-0.7	-1.0	0.6
Crohns Disease (2012)	0.2	0.4	2.6	-0.3	0.5	0.1	-0.2	-0.1	-0.4	0.4	-0.3	-0.4	1.6
LDL Cholesterol	0.2	0.3	1.5	0.2	-0.6	0.2	-0.1	-0.1	1.2	0.1	0.6	-1.0	-0.5
Triglycerides	0.2	0.3	1.8	-1.1	0.0	-0.2	-0.3	-0.2	-1.4	0.2	-0.3	0.2	0.1
Blood Red Count	0.2	1.5	8.5	0.0	-0.3	1.1	1.3	1.2	0.4	0.8	2.9	0.5	0.9
Cardiovascular Disease	0.2	0.7	2.5	-1.6	0.5	-1.0	0.6	-0.2	-0.5	-0.6	0.7	-0.7	-1.2
Lung FEV1/FVC ratio	0.2	1.2	4.2	2.0	0.9	1.1	0.8	1.1	1.3	0.7	1.2	-0.7	-0.4
Diabetes (mother)	0.2	0.3	0.9	-0.8	-0.1	0.5	0.1	-0.1	0.7	0.3	-0.9	0.1	0.8
Current tobacco smoking	0.2	0.3	0.7	-0.9	-0.5	-0.7	-0.7	-0.6	0.6	-0.1	-0.4	-0.6	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.8	-0.9	0.4	-0.7	0.1	0.1	0.8	0.2	-0.2	0.0	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	2.6	-0.2	0.1	0.5	0.2	0.5	1.6	0.4	1.1	-0.6	-0.3
Supplements: Glucosamine	0.2	0.3	1.0	0.0	0.1	0.3	-0.4	-0.1	-1.0	-0.1	0.4	-0.7	-1.0
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	1.2	-0.2	0.5	0.1	-0.5	-0.2	0.3	-0.4	-1.1	0.0	-0.2
Sitting height	0.2	1.2	3.3	-1.1	-0.6	-0.0	0.4	0.9	0.8	1.7	-0.7	1.8	1.5
Forced vital capacity (FVC)	0.2	0.7	3.8	0.8	0.5	-0.0	-0.2	0.5	-0.1	0.7	-1.9	1.1	-0.0
Diabetes (self-reported)	0.2	0.3	1.8	-0.4	0.3	-0.0	0.4	0.4	-0.0	0.4	-0.6	1.3	-0.4
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.3	-0.1	0.6	-0.1	0.5	0.3	0.6	0.5	-1.1	0.8	0.2
Asthma	0.2	0.5	3.0	-0.9	-0.1	-0.4	-0.2	0.1	0.2	0.2	-1.7	-0.7	-0.2
Medication: Cholesterol lowering	0.2	0.3	1.3	-1.2	0.9	0.5	0.4	0.3	-0.3	0.3	0.1	0.1	0.0
Pulse wave Arterial Stiffness index	0.2	0.3	1.3	-0.2	-0.9	0.1	-0.5	-0.4	1.1	-0.1	0.4	-0.1	-0.1
Hair/balding pattern: Pattern 4	0.2	0.6	3.6	0.1	0.3	-0.5	0.1	0.1	1.9	0.0	1.0	0.8	-0.6
Pulse wave reflection index	0.2	0.2	0.9	-0.3	0.4	1.0	0.3	0.2	0.1	-0.1	0.5	0.6	-0.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	2.4	1.5	-0.8	-0.4	-0.2	-0.0	0.4	0.1	0.3	-0.1	0.0
Wheeze or whistling in the chest in last year	0.2	0.4	1.7	-0.4	-0.1	-0.4	0.3	0.4	0.9	0.4	-0.6	1.3	0.1
Health satisfaction	0.2	0.2	1.3	-0.2	-0.4	-0.6	0.3	-0.0	0.2	0.0	1.1	0.2	-0.2
Age at last live birth	0.2	0.3	1.6	-0.5	-0.4	-0.1	-0.1	0.2	-0.2	0.3	-0.4	-1.2	0.6
Leg pain on walking	0.2	0.3	0.9	0.6	0.4	-0.1	0.6	0.3	-0.4	0.2	0.5	-0.7	-1.0
Hypertension (Self-reported)	0.2	0.5	1.6	-1.0	0.1	0.2	0.3	-0.2	-1.3	-0.7	0.9	-0.3	-0.6
Diabetes diagnosed by doctor	0.2	0.3	1.7	-0.8	0.0	-0.1	0.3	0.4	-0.1	0.8	-0.2	1.3	0.1
Medication for cholesterol	0.2	0.4	1.8	0.1	-0.2	-0.3	-0.4	0.2	-0.4	0.7	-0.9	0.3	1.4
Asthma (self-reported)	0.2	0.4	2.5	-0.9	-0.1	-0.4	-0.2	0.1	-0.1	0.2	-1.6	-0.7	0.0
Osteoporosis (self-reported)	0.2	0.3	0.9	0.7	0.1	0.2	0.1	-0.0	-0.8	-0.0	-1.0	-0.2	0.9
Osteoarthritis (self-reported)	0.2	0.3	1.1	-0.8	0.8	0.2	0.4	0.2	-1.1	0.3	-0.1	0.2	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	2.7	1.6	0.8	0.7	0.1	-0.0	-0.3	-0.4	-0.1	-0.8	-0.3
Miserableness	0.2	0.4	1.3	-0.5	0.6	0.3	0.2	-0.1	-1.1	-0.3	0.1	-0.7	-1.1
Medication: Blood pressure	0.2	0.4	1.0	-0.1	1.0	1.0	0.9	0.8	-0.0	0.3	0.5	0.8	0.2
High cholesterol (Self-reported)	0.2	0.4	2.6	-1.6	0.5	-0.1	0.1	0.1	-0.1	0.2	0.7	-0.0	-0.5
Medication: Bendroflumethiazide	0.2	0.3	1.0	-1.0	0.6	0.3	0.4	0.1	-0.8	0.0	0.2	0.6	-0.2
Medication: Lisinopril	0.2	0.2	1.1	-0.1	0.3	0.3	0.1	0.1	-0.9	-0.0	1.1	-0.3	0.0
Pain experienced in last month	0.2	0.3	2.2	0.3	0.1	0.2	-0.3	-0.3	0.0	-0.5	-1.5	-0.2	0.2
Irritable Bowel Disease (IBD)	0.1	0.3	0.6	-0.3	0.6	-0.3	0.5	0.3	-0.7	0.5	0.8	-0.8	0.1
Blood Eosinophil Count	0.1	0.7	2.0	-0.5	-0.8	-0.9	-0.9	-0.5	-0.3	-0.3	-1.4	1.3	-0.6
Height	0.1	1.4	2.8	0.5	0.9	0.7	0.8	1.4	1.3	1.7	-1.5	1.1	1.1
High blood pressure	0.1	0.3	0.8	-0.8	0.4	0.5	0.6	0.0	-0.9	-0.5	0.3	0.0	-0.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.9	0.8	0.4	-0.3	-0.4	0.1	-0.2	0.2	-0.9	0.4	-0.6
Standing height	0.1	1.1	3.6	-0.2	0.3	0.4	0.6	1.2	-1.6	1.9	-0.8	1.3	0.5
Forced vital capacity (FVC), Best measure	0.1	0.3	1.8	0.3	0.5	-0.2	0.1	0.3	-0.6	0.6	-1.3	0.1	0.1
Vascular/heart problems diagnosed by doctor	0.1	0.4	1.3	1.1	0.3	0.1	-0.5	0.3	0.8	0.6	-1.1	0.5	0.0
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	1.1	2.3	0.9	1.1	0.9	1.2	1.3	-0.3	1.5	-0.7	0.6	1.4
Tanning	0.0	0.4	1.9	-0.7	-0.5	-0.1	-0.4	-0.1	-1.4	0.5	0.1	0.7	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.4	0.2	0.2	-0.5	-0.2	-0.0	-0.2	0.0	-0.5	-0.6	-0.5

Hub : Genes

CACNA2D4

Models

Trait associations