Hub : Genes

CACNA2D4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1400	0.0440	1.1e-03	0.048	NA	0.076	NA	0.092	8.7e-05	NA	8.7e-07	NA	6.0e-08
2	GTEx	Brain Caudate basal ganglia	0.4500	0.1010	3.6e-05	0.187	NA	0.174	NA	0.168	4.8e-06	NA	1.0e-05	NA	1.5e-05
3	GTEx	Breast Mammary Tissue (Female)	0.1145	0.0740	1.0e-01	0.007	NA	-0.010	NA	-0.010	1.9e-01	NA	9.0e-01	NA	8.5e-01
4	GTEx	Colon Sigmoid	0.3590	0.0980	1.4e-03	0.111	NA	0.075	NA	0.108	9.9e-05	NA	1.3e-03	NA	1.2e-04
5	GTEx	Nerve Tibial	0.3581	0.0563	1.0e-12	0.200	NA	0.232	NA	0.262	3.6e-14	NA	2.0e-16	NA	1.1e-18
6	GTEx	Testis	0.1930	0.0760	7.3e-03	0.042	NA	-0.004	NA	0.012	6.1e-03	NA	5.8e-01	NA	9.2e-02
7	GTEx	Thyroid	0.1720	0.0510	3.3e-04	0.063	NA	0.065	NA	0.070	1.4e-05	NA	1.0e-05	NA	4.7e-06
8	METSIM	Adipose	0.0657	0.0251	3.2e-03	-0.001	0.016	0.007	0.017	0.005	4.3e-01	0.00140	2.4e-02	0.0012	5.8e-02
9	TCGA	Prostate Adenocarcinoma	0.0541	0.0264	8.6e-03	0.008	0.028	0.010	NA	0.022	4.4e-02	0.00060	2.5e-02	NA	2.3e-03
10	TCGA	Thyroid Carcinoma	0.0810	0.0330	5.0e-04	0.053	0.030	0.027	NA	0.044	7.0e-06	0.00058	1.1e-03	NA	3.6e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	3.7	5.9	31.5	-1.3	-0.5	-0.8	-0.7	-0.5	-5.6	-0.5	4.5	-0.7	-1.8
Bipolar Disorder or Schizophrenia	5.5	13.3	70.2	-2.4	-1.4	-2.6	-1.8	-1.7	-8.4	-1.6	5.0	-1.4	-3.5
Depressed Affect (Nagel 2018)	0.6	1.2	3.0	-1.2	-0.3	-1.3	-1.3	-1.7	0.1	-1.7	-0.1	-0.4	-0.8
Depression (Nagel 2018)	1.4	2.0	6.4	-2.5	-1.0	-1.8	-1.8	-1.6	-0.3	-1.4	0.3	-1.2	-0.4
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.8	0.6	1.2	0.8	0.2	0.1	1.3	0.1	-1.2	-0.0	0.6
Neuroticism (Nagel 2018)	1.8	4.1	8.2	-2.0	-1.6	-2.6	-2.5	-2.9	-2.5	-2.5	0.4	-1.1	-0.5
Schizophrenia (2018)	3.8	7.9	38.7	-2.0	-1.4	-2.7	-1.8	-1.8	-6.2	-1.6	2.7	-1.2	-3.1
Schizophrenia vs Biploar Disorder	0.5	0.7	2.8	-1.2	-0.8	-1.7	-0.6	-1.1	-0.0	-0.6	-0.1	-0.6	-0.1
Worry (Nagel 2018)	1.7	3.6	15.1	-1.2	-1.3	-2.2	-1.8	-2.1	-3.9	-2.0	0.5	-0.9	-0.1
Alzheimer’s Disease (in mother)	0.4	0.5	1.2	-0.2	-0.5	-1.1	-0.6	-0.8	-0.9	-0.3	0.8	0.3	-0.6
Alzheimer’s Disease (in father)	1.1	1.2	2.4	-1.0	-1.3	-1.4	-1.1	-1.2	0.1	-1.1	1.6	0.5	0.7
Alzheimer’s Disease (including proxy)	1.4	2.0	3.9	-1.1	-1.4	-2.0	-1.6	-2.0	-1.0	-1.9	1.0	0.3	-1.1
Crohns Disease (2017)	0.2	0.4	1.2	-1.0	-0.4	-0.9	-0.3	-0.6	-0.3	-0.0	0.5	-1.1	0.1
Irritable Bowel Disease (IBD)	0.1	0.3	0.6	-0.3	0.6	-0.3	0.5	0.3	-0.7	0.5	0.8	-0.8	0.1
Ulcerative Colitis (UC)	0.4	0.7	2.1	0.7	1.5	0.4	1.0	1.0	-0.9	0.8	0.7	-0.1	0.2
Major Depression (MDD)	0.5	0.6	1.6	-1.0	-0.6	-1.2	-0.6	-0.9	-0.9	-0.3	-0.6	-0.1	-0.3
Reaction Time	0.2	0.3	1.0	0.4	0.3	0.2	0.3	-0.2	0.6	0.5	-0.7	-1.0	0.6
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.4	0.9	1.6	0.7	0.6	0.5	0.3	0.5	-1.4	0.9	1.2
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	1.1	1.5	2.9	-1.0	-1.1	-1.5	-1.7	-1.6	-0.8	-1.4	-1.3	-1.0	0.5
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.4	0.6	2.1	0.4	0.6	1.2	0.3	0.5	-1.3	0.1	-1.4	0.1	0.4
Bipolar Disorder (2011)	2.3	2.3	17.7	-0.7	0.0	0.2	0.0	-0.1	-4.2	-0.5	1.5	-1.1	-0.9
Body Mass Index (BMI) (2010)	0.4	0.6	1.8	-0.8	-0.0	-0.5	-0.4	-0.6	-1.4	-0.6	1.4	0.3	-0.6
Coronary Artery Disease (CAD)	0.7	0.9	2.3	0.1	0.7	0.0	0.3	-0.4	-1.2	-1.1	1.1	-1.5	-1.5
Crohns Disease (2012)	0.2	0.4	2.6	-0.3	0.5	0.1	-0.2	-0.1	-0.4	0.4	-0.3	-0.4	1.6
Mean Putamen Volume	1.0	1.2	4.0	1.1	1.0	0.7	0.7	0.7	-0.1	1.0	0.3	1.8	2.0
Fasting Glucose	0.7	0.8	2.3	-0.8	-0.4	-1.0	-0.4	-0.7	-0.9	-0.4	1.5	1.3	-1.0
HbA1C	1.4	1.5	4.2	1.0	0.8	0.9	1.3	1.2	1.5	1.9	0.0	2.0	0.0
HDL Cholesterol	0.3	0.5	1.1	-0.2	-1.1	-0.9	-0.9	-0.6	0.6	-0.7	-0.9	-0.5	-0.3
LDL Cholesterol	0.2	0.3	1.5	0.2	-0.6	0.2	-0.1	-0.1	1.2	0.1	0.6	-1.0	-0.5
Lupus	0.5	0.7	2.8	-1.7	-0.9	-0.6	-0.3	-0.5	-0.5	-0.4	0.8	1.2	0.3
Neuroticism (2016)	1.0	1.4	6.8	-0.9	-0.8	-0.9	-1.2	-1.4	-2.6	-1.1	0.6	-0.1	0.1
Primary Biliary Cirrhosis	0.7	1.0	2.8	-0.1	1.1	1.0	1.1	1.1	-1.4	0.8	-0.7	0.0	1.7
Rheumatoid Arthritis	0.7	1.0	2.6	0.7	1.6	0.8	1.3	0.9	-0.3	0.8	-1.5	0.1	0.5
Schizophrenia (2014)	4.9	10.7	56.8	-2.9	-1.6	-3.0	-1.9	-2.2	-7.5	-1.9	2.9	-1.3	-2.9
Triglycerides	0.2	0.3	1.8	-1.1	0.0	-0.2	-0.3	-0.2	-1.4	0.2	-0.3	0.2	0.1
Type 2 Diabetes (T2D) (2012)	0.5	0.6	2.6	0.5	1.0	0.6	0.4	0.6	-1.6	1.2	-0.1	0.4	0.4
Ulcerative Colitis	2.0	2.9	7.5	1.3	2.7	1.8	2.0	2.2	-1.3	1.9	0.2	0.9	0.9
Blood Eosinophil Count	0.1	0.7	2.0	-0.5	-0.8	-0.9	-0.9	-0.5	-0.3	-0.3	-1.4	1.3	-0.6
Blood Platelet Count	0.3	3.1	10.6	-0.9	0.5	0.2	1.5	1.2	-1.4	1.4	-3.3	1.9	2.8
Blood Red Count	0.2	1.5	8.5	0.0	-0.3	1.1	1.3	1.2	0.4	0.8	2.9	0.5	0.9
Blood White Count	0.3	1.9	4.8	-1.9	-1.3	-1.2	-0.8	-1.2	0.5	-1.1	-2.2	1.7	1.2
Heel T-Score	0.6	4.5	28.3	-1.1	-2.1	-0.5	-0.9	-0.8	2.1	-1.0	5.3	-1.6	-1.3
BMI	0.5	2.7	8.4	-2.5	-0.3	-1.2	-0.1	-0.7	1.1	-1.1	2.9	0.8	-2.7
Height	0.1	1.4	2.8	0.5	0.9	0.7	0.8	1.4	1.3	1.7	-1.5	1.1	1.1
Waist Hip Ratio (WHR)	0.6	2.8	11.0	1.3	1.8	0.7	1.4	1.1	-3.3	1.6	-1.1	1.4	1.6
Systolic Blood Pressure	0.3	1.4	4.2	0.6	0.9	1.0	1.4	1.4	2.0	1.1	0.6	1.4	-0.2
Smoking Status	0.3	0.7	2.9	-0.7	-0.5	-0.4	-0.3	-0.1	-1.7	0.4	1.4	-0.3	-0.7
Allergy or Eczema	0.8	2.2	3.7	-0.8	-1.3	-1.5	-1.5	-1.7	1.6	-1.9	-1.0	-1.5	-1.5
Cardiovascular Disease	0.2	0.7	2.5	-1.6	0.5	-1.0	0.6	-0.2	-0.5	-0.6	0.7	-0.7	-1.2
Hypothyroidism (self reported)	0.3	0.8	5.7	-0.0	-0.0	0.3	-0.3	-0.2	0.8	-0.5	2.4	0.6	-0.6
Respiratory disease	0.7	1.5	3.6	-1.5	-1.0	-1.4	-0.9	-0.9	-0.7	-0.8	-1.9	-1.5	-1.0
Type 2 Diabetes (T2D) (2018)	0.4	0.8	3.3	-0.6	0.7	0.6	1.0	1.0	-0.3	1.1	-0.2	1.8	-0.3
Lung FEV1/FVC ratio	0.2	1.2	4.2	2.0	0.9	1.1	0.8	1.1	1.3	0.7	1.2	-0.7	-0.4
Lung FVC	0.4	1.9	4.6	-0.6	-1.4	-1.4	-2.1	-2.1	-0.3	-1.7	-1.2	0.2	-0.9
Neuroticism	0.8	1.9	8.2	-1.1	-0.7	-1.4	-1.2	-1.8	-2.9	-1.6	0.5	-0.4	-0.4
Chronotype (morning person)	0.7	1.5	6.2	-0.3	0.9	0.9	1.0	0.8	1.1	1.0	-1.6	0.8	2.5
Hair Pigment	0.0	1.1	2.3	0.9	1.1	0.9	1.2	1.3	-0.3	1.5	-0.7	0.6	1.4
Tanning	0.0	0.4	1.9	-0.7	-0.5	-0.1	-0.4	-0.1	-1.4	0.5	0.1	0.7	-0.6
Hand grip strength (left)	0.4	1.0	2.5	1.4	0.6	0.9	1.3	1.6	0.0	1.3	-0.4	0.3	0.8
Number of treatments/medications taken	1.7	3.0	9.9	-3.1	-0.8	-1.4	-1.1	-1.5	-0.6	-1.5	2.4	-0.8	-2.3
Average weekly spirits intake	0.5	0.6	1.2	-0.9	-0.7	-0.8	-0.4	-0.6	1.0	-1.0	0.5	0.1	-1.1
Sensitivity / hurt feelings	0.9	1.6	3.2	-1.0	-1.1	-1.8	-1.4	-1.7	-1.2	-1.3	-0.9	-1.3	0.1
Frequency of depressed mood in last 2 weeks	0.8	1.2	4.9	-2.2	-0.4	-1.1	-0.7	-0.7	-1.6	-0.4	1.0	-0.7	-0.3
Hearing difficulty/problems: Yes	0.4	0.6	2.2	-0.9	-0.2	-0.5	-0.1	-0.4	1.0	-0.4	0.8	-0.4	-1.5
Relative age of first facial hair	1.9	3.9	9.8	2.5	2.3	3.1	2.1	2.4	-0.5	1.8	-1.0	0.9	1.4
Other serious medical condition/disability diagnosed by doctor	2.1	2.8	5.3	-2.0	-1.1	-2.3	-2.2	-2.3	-1.3	-1.8	0.3	-0.9	-1.2
Ever used hormone-replacement therapy (HRT)	3.1	4.0	7.1	-2.7	-2.3	-2.1	-2.0	-2.2	-0.9	-2.4	1.5	-0.9	-2.2
Ever had hysterectomy (womb removed)	0.5	0.6	3.1	-0.2	-0.5	-0.5	-0.4	-0.5	1.8	-1.0	-0.8	-0.3	-0.6
Systolic blood pressure, automated reading	0.5	1.3	3.8	-1.7	-0.9	-0.6	-0.7	-0.8	2.0	-0.7	1.7	-0.1	-1.0
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.1	0.4	0.7	0.1	0.5	0.6	0.6	1.1	-0.1	0.6	0.2
Angina	1.2	1.6	4.8	-2.2	-1.2	-1.5	-0.7	-0.9	-0.2	-0.8	1.9	-0.4	-1.2
Medication for hormone replacement therapy	1.8	2.0	4.3	-0.6	-2.1	-1.6	-1.0	-1.4	-2.1	-1.5	1.0	-0.8	-1.3
Vitamin and mineral supplements	1.5	2.1	3.7	1.5	1.7	1.3	1.4	1.4	0.2	1.4	-0.9	1.9	1.9
Supplements: Zinc	0.4	0.5	1.7	-0.9	-0.9	-0.7	-0.5	-0.4	-0.3	-0.5	-0.0	-0.6	-1.3
Medication: Co-codamol	0.4	0.5	2.8	0.0	0.1	0.1	-0.7	0.0	1.7	-0.2	-0.2	-0.7	-0.8
Medication: Metformin	0.4	0.5	2.9	-0.1	-0.4	0.4	0.2	0.3	-0.5	0.9	0.4	1.7	0.9
Diabetes (father)	0.5	0.6	2.4	-0.7	-0.8	-0.9	-0.4	-0.2	-0.9	-0.0	1.1	-0.2	-1.5
Diabetes (mother)	0.2	0.3	0.9	-0.8	-0.1	0.5	0.1	-0.1	0.7	0.3	-0.9	0.1	0.8
Severe depression (siblings)	0.4	0.4	1.0	0.6	0.6	0.7	0.4	1.0	-0.9	1.0	-0.3	-0.1	0.5
Pack years adult smoking proportion	3.6	5.5	11.2	-0.1	1.5	1.4	2.5	2.4	2.4	3.3	-1.9	2.9	3.1
Impedance of leg (right)	0.5	2.2	11.0	1.0	-0.5	1.0	0.8	1.1	-3.3	1.4	0.9	0.9	1.9
Leg fat-free mass (left)	0.4	2.1	7.1	-2.1	-0.4	-1.5	-0.9	-0.9	2.7	-0.7	0.0	-0.1	-2.2
Trunk fat percentage	0.8	3.3	12.7	-2.8	-1.8	-0.9	-1.4	-1.4	1.0	-1.1	3.6	0.3	-1.3
Hand grip strength (right)	0.5	1.3	2.7	1.4	0.6	1.1	1.3	1.6	-0.2	1.4	0.4	1.2	1.0
Townsend deprivation index at recruitment	0.3	0.4	1.6	0.0	0.1	-0.0	0.5	0.1	0.5	-0.1	-0.9	-1.2	-1.3
Current tobacco smoking	0.2	0.3	0.7	-0.9	-0.5	-0.7	-0.7	-0.6	0.6	-0.1	-0.4	-0.6	-0.4
Average weekly fortified wine intake	0.8	0.9	1.6	0.1	1.1	1.3	0.9	1.0	-1.1	1.3	-0.3	0.5	1.1
Maternal smoking around birth	0.6	0.8	2.8	-0.2	0.0	-0.2	1.4	0.7	-0.5	1.2	0.6	0.6	1.7
Fed-up feelings	0.6	1.1	3.2	-1.1	-0.6	-1.3	-0.7	-1.4	1.8	-1.1	-0.0	-0.5	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.8	-0.9	0.4	-0.7	0.1	0.1	0.8	0.2	-0.2	0.0	-0.3
Relative age voice broke	2.3	3.5	8.3	2.6	2.3	2.9	1.8	2.2	-1.6	1.0	-0.5	1.6	-0.0
Taking other prescription medications	0.5	0.8	3.3	-1.4	-0.4	-0.8	0.4	-0.1	-0.1	0.6	1.8	1.0	-0.2
Age when periods started (menarche)	1.5	3.5	7.8	1.1	2.3	1.3	1.7	1.8	-2.8	2.1	-1.0	1.2	2.6
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.2	1.0	1.1	0.5	1.0	1.1	1.5	0.6	-0.3	0.2	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	2.6	-0.2	0.1	0.5	0.2	0.5	1.6	0.4	1.1	-0.6	-0.3
Tinnitus: Yes, but not now, but have in the past	1.0	1.0	2.2	0.5	1.4	0.7	1.5	1.2	-0.9	1.4	0.0	0.1	1.1
Qualifications: CSEs or equivalent	0.8	1.1	6.8	-0.6	0.5	-0.1	0.9	0.4	2.6	0.5	1.1	-1.0	0.3
Serious illness, injury or assault to yourself	0.4	0.5	1.5	0.4	0.1	-0.8	-0.5	-0.5	-0.8	-0.5	-0.2	-1.2	-1.1
High blood pressure	0.1	0.3	0.8	-0.8	0.4	0.5	0.6	0.0	-0.9	-0.5	0.3	0.0	-0.1
Hayfever, allergic rhinitis or eczema	0.7	1.5	3.7	-0.6	-0.5	-1.2	-0.7	-1.0	1.9	-1.4	-1.2	-1.4	-1.6
Multivitamins +/- minerals	3.9	5.0	7.4	-2.5	-2.7	-2.7	-2.4	-2.3	0.3	-1.9	1.9	-2.3	-2.3
Stomach or abdominal pain in last month	0.6	0.8	2.2	-0.8	1.1	0.4	1.0	0.9	1.0	1.5	-0.4	0.5	0.4
Supplements: Glucosamine	0.2	0.3	1.0	0.0	0.1	0.3	-0.4	-0.1	-1.0	-0.1	0.4	-0.7	-1.0
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	1.2	-0.2	0.5	0.1	-0.5	-0.2	0.3	-0.4	-1.1	0.0	-0.2
Medication: Atenolol	0.4	0.5	1.6	-0.8	0.1	-0.4	0.5	-0.1	-1.3	0.6	0.7	1.2	0.2
Medication: Levothyroxine sodium	0.5	0.9	2.8	0.3	1.1	0.7	1.1	0.8	0.6	0.6	1.7	0.9	0.9
Sitting height	0.2	1.2	3.3	-1.1	-0.6	-0.0	0.4	0.9	0.8	1.7	-0.7	1.8	1.5
Chronic bronchitis/emphysema (father)	3.6	4.3	10.2	-2.8	-3.2	-2.6	-2.7	-2.6	0.3	-1.6	-0.2	-0.3	1.0
High blood pressure (mother)	0.5	0.7	3.7	-0.1	-1.0	-0.8	-0.4	-0.8	0.9	-0.7	-0.1	-1.9	-0.2
Body mass index (BMI)	0.8	3.4	11.8	-2.5	-0.7	-1.1	-1.1	-1.3	3.4	-1.6	2.1	-0.3	-2.2
Impedance of leg (left)	0.6	2.8	14.8	0.9	-0.6	1.1	0.8	1.0	-3.8	1.3	1.0	0.9	2.4
Leg predicted mass (left)	0.4	2.2	6.8	-2.2	-0.5	-1.6	-1.0	-1.0	2.6	-0.8	-0.0	-0.1	-2.2
Trunk fat mass	0.8	3.3	10.6	-2.9	-1.6	-1.2	-1.4	-1.3	1.4	-1.1	3.2	0.4	-1.7
Waist circumference	0.4	1.3	3.6	-1.9	-0.2	-0.9	-0.6	-0.8	1.6	-0.7	1.7	0.2	-1.2
Number of incorrect matches in round	1.2	1.9	6.4	-1.3	-2.1	-1.4	-1.3	-1.3	-2.5	-0.9	0.9	0.4	0.1
Past tobacco smoking	0.8	1.4	5.3	1.3	1.3	0.6	1.3	1.1	2.3	0.6	-1.1	-0.1	0.9
Alcohol usually taken with meals	3.4	5.5	11.5	1.8	1.8	3.0	2.6	2.5	-1.5	3.0	-0.8	1.9	3.4
Nervous feelings	1.1	2.1	9.6	-1.3	-1.1	-1.0	-1.1	-1.2	-3.1	-1.3	1.1	-1.0	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.4	-1.0	-1.0	-1.1	-0.4	-0.7	-1.2	-0.4	0.3	0.3	0.1
Hearing difficulty/problems with background noise	0.9	1.4	3.2	-1.0	-0.8	-1.4	-1.3	-1.3	-0.3	-1.3	1.8	-0.8	-1.3
Hair/balding pattern: Pattern 2	1.1	1.3	3.4	1.1	1.8	1.4	1.1	1.3	-0.9	1.5	-0.5	-0.2	0.8
Had menopause	0.7	0.9	4.3	-2.1	-1.1	-0.6	-0.9	-1.0	-0.0	-0.8	-0.2	0.0	0.7
Had other major operations	0.8	1.0	2.2	1.3	0.8	1.5	1.4	1.4	0.6	0.8	0.8	0.2	-0.1
Forced vital capacity (FVC)	0.2	0.7	3.8	0.8	0.5	-0.0	-0.2	0.5	-0.1	0.7	-1.9	1.1	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	3.5	-0.1	0.9	1.6	0.8	1.4	1.9	1.0	1.1	-0.0	0.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.9	0.4	0.6	-0.7	0.8	0.4	1.2	-0.2	1.0	-0.5	-1.7
Qualifications: None of the above	1.2	2.6	8.0	-1.9	-2.3	-2.8	-1.3	-2.0	1.1	-1.3	0.8	-0.0	-0.6
Financial difficulties in last 2 years	0.8	1.1	3.4	-0.9	0.4	-0.7	-0.7	-0.7	1.9	-1.0	-1.1	-0.7	-1.4
Mouth/teeth dental problems	0.4	0.5	2.7	1.6	0.7	0.9	-0.1	0.4	-0.4	0.4	0.1	1.0	0.2
Heart attack	0.4	0.5	0.9	-0.8	-0.6	-0.2	-0.6	-1.0	-0.7	-0.9	0.6	-0.8	0.3
Allergy	0.5	1.1	2.4	1.1	-0.1	0.7	0.4	0.5	-1.4	0.9	1.4	1.6	1.2
Pain all over the body in last month	0.6	0.6	1.6	0.8	0.9	0.8	1.3	0.9	0.4	0.7	0.5	0.4	0.7
Diabetes (self-reported)	0.2	0.3	1.8	-0.4	0.3	-0.0	0.4	0.4	-0.0	0.4	-0.6	1.3	-0.4
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.3	-0.1	0.6	-0.1	0.5	0.3	0.6	0.5	-1.1	0.8	0.2
Medication: Ramipril	0.3	0.4	1.4	-1.2	0.6	0.3	0.1	-0.1	-0.3	-0.5	-0.0	-0.9	-1.0
Medication: Simvastatin	0.3	0.4	2.1	-1.4	1.1	-0.0	0.1	-0.3	0.4	-0.5	-0.6	-0.2	-0.4
Fluid intelligence score	1.5	3.2	6.6	2.3	2.6	2.3	1.4	1.7	-0.4	1.4	-0.8	2.2	1.4
Illnesses of siblings	1.0	1.4	9.5	0.0	-0.8	-0.9	-1.4	-0.9	-0.3	-0.3	-3.1	-0.1	0.2
Neuroticism score	0.7	1.4	5.5	-0.8	-0.6	-1.2	-1.0	-1.5	-2.3	-1.5	0.0	-0.6	-0.6
Weight	0.5	2.3	6.4	-2.5	-0.7	-1.1	-1.0	-0.9	2.5	-0.9	1.5	0.0	-1.9
Impedance of arm (right)	0.4	1.8	12.3	1.0	-0.6	0.8	-0.6	0.1	-3.5	0.7	-0.6	0.5	1.4
Arm fat percentage (right)	0.8	3.3	8.0	-2.2	-1.4	-1.1	-1.6	-1.6	2.2	-1.5	2.8	-0.4	-2.1
Trunk fat-free mass	0.3	1.7	5.5	-1.8	-0.2	-1.6	-0.7	-0.8	2.3	-0.7	-0.4	-0.5	-2.0
Hip circumference	0.8	3.6	7.5	-2.7	-1.2	-1.4	-1.2	-1.3	2.6	-1.4	2.7	-0.6	-2.2
Time employed in main current job	1.2	1.4	11.2	1.1	0.7	0.2	0.1	0.2	3.3	0.2	-0.7	0.3	-0.2
Alcohol intake versus 10 years previously	0.4	0.6	3.0	-0.8	0.5	-0.5	0.5	0.1	0.9	-0.1	-1.1	0.2	-1.7
Father’s age at death	1.0	1.3	4.5	2.1	0.5	0.9	0.4	0.7	-1.3	1.1	0.6	0.7	1.9
Worrier / anxious feelings	1.1	2.0	18.4	0.3	-0.2	-0.9	-0.3	-0.4	-4.3	-0.4	0.3	0.2	-0.0
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.2	7.1	-1.1	-1.6	-2.7	-1.5	-1.7	1.6	-0.9	1.0	0.2	-1.1
Falls in the last year	0.9	1.2	2.4	1.2	0.7	0.9	0.8	0.9	-1.6	1.2	-0.8	1.1	1.5
Hair/balding pattern: Pattern 3	1.0	1.4	3.8	-1.9	-1.3	-0.9	-0.6	-1.1	-0.4	-1.4	0.6	-1.8	-0.9
Number of live births	0.5	0.7	4.2	0.4	0.0	0.2	1.0	0.7	2.1	0.6	-0.3	-0.0	0.5
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.9	0.8	0.4	-0.3	-0.4	0.1	-0.2	0.2	-0.9	0.4	-0.6
Pulse rate	1.2	2.0	9.4	0.1	-1.5	-1.0	-1.0	-1.1	3.1	-1.0	-1.2	-1.4	-0.8
Happiness	0.5	0.6	1.3	-0.6	-0.7	-0.7	-0.5	-0.6	1.0	-0.6	1.1	-0.7	-0.8
Noisy workplace	0.3	0.4	2.9	-0.0	0.3	0.2	-0.2	-0.2	-0.0	-0.4	-0.2	-1.7	-1.0
Qualifications: A levels/AS levels or equivalent	0.4	0.9	3.4	-0.7	-0.9	-0.3	-1.9	-1.3	0.6	-0.9	-0.7	-1.0	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	2.0	-0.9	0.4	0.5	0.7	0.9	0.9	0.8	0.0	1.4	0.6
Mouth/teeth dental problems: Dentures	0.8	1.3	6.4	-1.3	-0.9	-0.9	-0.7	-1.0	0.3	-0.7	-2.5	-0.1	0.9
Asthma	0.2	0.5	3.0	-0.9	-0.1	-0.4	-0.2	0.1	0.2	0.2	-1.7	-0.7	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.1	-0.3	-0.1	-0.7	-0.6	-0.7	0.5	-1.0	0.2	-0.1	-0.9
Medication: Cholesterol lowering	0.2	0.3	1.3	-1.2	0.9	0.5	0.4	0.3	-0.3	0.3	0.1	0.1	0.0
Depression (self-reported)	1.9	2.3	5.9	-1.7	-0.8	-1.9	-1.1	-1.6	0.7	-1.8	0.7	-1.4	-2.4
Medication: Lansoprazole	0.5	0.6	4.7	0.5	-0.1	0.0	0.1	0.2	2.2	-0.1	-0.4	0.4	-0.9
Prospective memory result	1.5	1.9	4.9	-0.9	-1.9	-2.2	-1.1	-1.6	-1.6	-0.9	0.6	-1.0	-1.0
Lung cancer (father)	0.4	0.5	2.3	0.1	0.3	-0.2	0.6	0.8	0.5	1.5	-0.5	0.6	0.9
Illnesses of mother	1.2	1.4	3.3	1.1	1.8	1.8	1.2	1.5	-1.0	1.1	-0.7	0.6	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.4	0.2	0.2	-0.5	-0.2	-0.0	-0.2	0.0	-0.5	-0.6	-0.5
Pulse wave Arterial Stiffness index	0.2	0.3	1.3	-0.2	-0.9	0.1	-0.5	-0.4	1.1	-0.1	0.4	-0.1	-0.1
Impedance of arm (left)	0.6	2.6	12.1	1.5	0.1	1.5	0.5	1.2	-3.5	1.7	-0.1	1.1	1.9
Arm fat mass (right)	0.8	3.4	6.6	-2.6	-1.4	-1.4	-1.6	-1.6	2.6	-1.5	2.3	-0.2	-2.1
Trunk predicted mass	0.3	1.7	5.7	-1.7	-0.1	-1.6	-0.6	-0.7	2.4	-0.6	-0.4	-0.5	-2.0
Standing height	0.1	1.1	3.6	-0.2	0.3	0.4	0.6	1.2	-1.6	1.9	-0.8	1.3	0.5
Length of working week for main job	5.8	6.4	13.5	-2.0	-2.4	-3.7	-2.8	-3.2	-0.7	-2.8	0.0	-2.2	-3.0
Exposure to tobacco smoke at home	0.5	0.6	1.4	-0.4	-0.9	-0.4	-1.1	-1.2	-0.6	-1.2	0.4	-0.6	0.3
Breastfed as a baby	0.4	0.5	2.3	0.5	-0.1	0.7	0.2	0.3	-0.5	0.3	1.1	1.5	-0.5
Tense / ‘highly strung’	2.6	4.3	19.5	-1.9	-1.9	-2.2	-1.7	-2.0	-4.4	-1.2	1.5	-0.2	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	2.4	3.6	8.7	-2.0	-2.2	-3.0	-1.8	-2.4	-1.9	-2.0	0.9	-0.9	-0.2
Hair/balding pattern: Pattern 4	0.2	0.6	3.6	0.1	0.3	-0.5	0.1	0.1	1.9	0.0	1.0	0.8	-0.6
Birth weight of first child	1.5	2.7	4.3	-1.2	-1.9	-1.8	-2.0	-2.1	1.4	-1.9	1.5	-1.2	-1.2
Peak expiratory flow (PEF)	0.3	0.7	2.1	0.9	-0.2	-0.4	-1.0	-0.6	-1.4	-0.8	-0.8	-1.0	-0.8
Pulse wave reflection index	0.2	0.2	0.9	-0.3	0.4	1.0	0.3	0.2	0.1	-0.1	0.5	0.6	-0.1
Ever highly irritable/argumentative for 2 days	3.5	4.2	9.2	2.2	2.7	2.9	3.0	2.8	0.4	1.9	0.2	0.4	0.5
Loud music exposure frequency	0.6	0.7	4.2	1.2	0.8	0.1	0.1	-0.1	-0.1	-0.4	0.2	-0.7	-2.1
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.5	-1.3	-0.6	-0.2	-1.6	-0.8	-1.1	-0.7	-1.0	-1.0	1.2
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.7	-1.3	-0.2	-0.3	0.1	0.2	0.6	-0.0	1.0	-0.5	-0.7
Blood clot in the leg (DVT)	0.7	0.9	2.5	-0.1	1.4	1.6	0.5	1.1	-0.2	1.3	0.4	0.2	0.8
Medication: Paracetamol	0.7	1.1	5.1	-0.5	-0.8	-0.9	-0.7	-0.9	0.6	-0.7	2.3	-0.9	-1.2
Headache pain in last month	0.5	0.8	5.3	-0.6	-0.2	-0.6	-0.3	-0.6	2.3	-0.5	-0.6	-0.7	-0.8
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	2.4	1.5	-0.8	-0.4	-0.2	-0.0	0.4	0.1	0.3	-0.1	0.0
Glaucoma (self-reported)	2.1	2.5	5.8	2.4	1.5	1.8	1.8	1.7	-0.1	1.1	2.3	0.7	-0.6
Gout (self-reported)	0.6	0.8	3.3	0.0	-0.3	-1.1	-0.5	-0.8	-1.1	-0.9	-1.8	0.3	-0.5
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	4.7	0.3	0.1	0.4	0.2	-0.0	0.3	-0.2	2.2	0.7	0.2
Medication: Amlodipine	0.4	0.6	1.9	-1.3	-0.2	-0.4	-0.3	-0.6	-0.0	-1.0	0.1	-0.8	-1.4
Medication: Ventolin 100micrograms inhaler	0.9	1.2	2.8	0.3	1.1	0.4	1.6	1.3	-1.7	1.3	-0.2	-1.0	0.3
Birth weight	1.7	3.6	7.5	-2.6	-2.6	-1.5	-2.7	-2.4	-0.7	-2.2	-0.1	-1.1	0.2
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.4	-1.2	-0.8	-0.9	-0.4	-0.5	0.4	0.1	0.1	0.2	0.8
High blood pressure (siblings)	0.9	1.3	6.7	0.4	0.0	1.2	0.7	0.6	-0.1	0.4	2.6	1.2	1.4
Forced vital capacity (FVC), Best measure	0.1	0.3	1.8	0.3	0.5	-0.2	0.1	0.3	-0.6	0.6	-1.3	0.1	0.1
Body fat percentage	0.9	3.4	12.4	-2.7	-1.8	-1.1	-1.4	-1.4	1.5	-1.3	3.5	0.4	-1.4
Leg fat percentage (right)	0.8	2.8	14.0	-1.9	-1.1	-0.7	-0.6	-0.7	2.2	-1.0	3.7	0.7	-1.4
Arm fat-free mass (right)	0.4	1.8	5.7	-2.2	-0.2	-1.4	-0.2	-0.5	2.4	-0.6	0.7	-0.1	-2.1
Exposure to tobacco smoke outside home	1.1	1.4	2.7	0.8	1.4	1.6	1.3	1.2	1.6	1.1	1.0	-0.1	0.7
Comparative body size at age 10	0.6	1.6	11.0	-0.1	-0.9	-1.0	-0.8	-0.5	3.3	-0.6	0.4	-0.7	-1.3
Number of full brothers	0.9	1.1	2.6	0.8	1.3	0.3	1.6	1.2	1.5	1.4	0.4	0.3	0.6
Worry too long after embarrassment	0.9	1.5	3.8	-1.0	-1.0	-1.4	-1.1	-1.2	-1.9	-0.8	1.9	-0.6	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	8.2	-0.3	-0.1	-1.0	0.2	-0.4	-2.9	-0.4	0.4	-0.7	-0.3
Wheeze or whistling in the chest in last year	0.2	0.4	1.7	-0.4	-0.1	-0.4	0.3	0.4	0.9	0.4	-0.6	1.3	0.1
Number of children fathered	1.5	1.7	4.7	0.9	1.4	1.2	1.0	1.3	-1.1	1.3	0.1	1.8	2.2
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	6.6	0.1	0.7	1.2	1.1	1.4	-2.6	1.4	0.3	1.7	0.9
Age at first live birth	0.5	0.8	3.4	0.5	0.6	0.9	0.4	0.9	-1.9	0.5	-0.3	-0.1	1.4
Pulse wave peak to peak time	0.3	0.4	1.4	0.3	1.1	-0.0	0.7	0.6	-1.2	0.5	-0.4	0.2	0.1
Health satisfaction	0.2	0.2	1.3	-0.2	-0.4	-0.6	0.3	-0.0	0.2	0.0	1.1	0.2	-0.2
Shortness of breath walking on level ground	0.4	0.4	1.6	-0.8	0.1	-0.3	-0.1	-0.6	-0.1	-0.8	1.3	1.0	-0.3
Qualifications: College or University degree	0.6	1.9	5.8	1.7	1.4	2.4	0.4	1.2	-2.1	0.8	-0.4	-0.1	1.0
Eye problems/disorders: None of the above	1.6	1.8	2.8	-0.7	-1.7	-1.5	-1.7	-1.4	0.4	-1.5	-0.7	-1.6	-1.6
Mouth/teeth dental problems: Loose teeth	1.9	2.2	5.7	-1.6	-1.8	-1.9	-1.2	-1.5	-0.3	-0.9	2.4	-0.7	-1.3
Emphysema/chronic bronchitis	1.2	1.4	3.1	-1.4	-1.3	-1.2	-0.6	-1.0	-1.8	-0.7	-0.9	-1.7	-0.1
Medication for pain relief, constipation, heartburn	0.9	1.6	5.2	2.3	1.0	1.1	0.9	1.2	1.2	0.7	-2.0	-0.0	0.5
Neck or shoulder pain in last month	0.5	0.7	2.7	-0.9	-0.4	-0.6	0.0	0.1	-1.6	0.1	0.9	1.3	0.4
Medication: Blood pressure	0.3	0.4	1.4	-0.3	1.2	1.1	0.9	0.6	-0.4	0.3	0.3	0.5	0.0
Angina (self-reported)	1.1	1.5	5.4	-2.3	-1.1	-1.3	-0.7	-0.9	-0.3	-0.8	1.8	-0.2	-1.1
Migraine (self-reported)	1.2	1.5	2.8	0.7	1.5	1.2	1.5	1.7	-0.1	1.6	-0.4	1.5	0.6
Medication: Ibuprofen	0.7	0.9	1.6	-1.0	-0.5	-1.0	-1.1	-1.1	-0.0	-1.2	0.7	-0.7	-1.3
Medication: Allopurinol	0.6	0.8	2.3	0.3	-0.8	-1.5	-0.4	-1.0	-1.1	-1.2	-0.1	0.4	-1.2
Medication: Omeprazole	2.0	2.4	5.9	-2.4	-1.2	-1.5	-2.0	-2.0	-0.8	-1.9	1.1	-0.4	-1.2
Medication: Seretide 50 evohaler	1.9	2.2	4.5	-1.3	-1.7	-1.9	-1.3	-1.4	-2.1	-1.0	1.8	-1.2	0.8
Mean time to correctly identify matches	0.4	0.7	2.8	-0.3	-0.6	-0.5	-0.8	-1.3	0.9	-0.5	-0.7	-1.7	0.5
Heart disease (mother)	0.4	0.5	2.7	-1.1	-0.4	-0.3	0.2	-0.1	-0.4	-0.2	1.6	0.7	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	4.7	5.6	11.8	-1.8	-3.0	-2.9	-2.7	-2.7	0.2	-3.4	-0.6	-1.9	-2.3
Whole body fat mass	0.9	3.8	9.5	-3.0	-1.7	-1.5	-1.6	-1.6	1.9	-1.5	3.1	0.2	-2.0
Leg fat mass (right)	0.8	3.1	8.2	-2.4	-1.1	-1.3	-1.0	-1.2	2.5	-1.2	2.9	0.5	-1.8
Arm predicted mass (right)	0.4	2.3	6.7	-2.5	-0.6	-1.8	-0.4	-0.8	2.6	-0.7	0.7	-0.3	-2.1
Pulse rate, automated reading	1.2	3.9	8.7	-2.1	-1.1	-1.7	-1.7	-1.7	2.9	-2.0	-1.7	-2.0	-2.3
Alcohol intake frequency.	1.3	2.9	6.4	-2.5	-0.8	-1.7	-1.4	-1.7	1.5	-1.7	-2.4	-1.4	-1.4
Comparative height size at age 10	0.6	3.1	8.4	-2.9	-2.5	-2.6	-2.1	-1.4	0.2	-0.6	0.1	-0.5	-1.8
Number of full sisters	0.3	0.3	0.9	0.2	0.7	0.4	0.6	0.9	0.2	0.9	0.3	-0.1	-0.6
Suffer from ‘nerves’	1.3	2.0	3.7	-1.8	-1.2	-1.9	-1.4	-1.8	-1.0	-1.7	-0.6	-1.3	-1.0
Overall health rating	1.2	2.7	9.2	-2.3	-1.3	-2.1	-1.1	-1.5	3.0	-1.0	0.1	-1.1	-0.1
Chest pain or discomfort	0.4	0.6	2.8	-1.7	-0.3	-0.4	0.2	-0.2	1.3	0.3	0.8	0.8	0.1
Had major operations	3.3	3.9	8.8	-2.2	-1.2	-2.7	-1.5	-2.0	0.3	-2.1	-0.5	-2.4	-3.0
Age at last live birth	0.2	0.3	1.6	-0.5	-0.4	-0.1	-0.1	0.2	-0.2	0.3	-0.4	-1.2	0.6
Family relationship satisfaction	0.4	0.4	1.9	-0.2	0.1	0.1	0.4	0.3	-0.2	0.4	0.7	1.4	1.2
Leg pain on walking	0.2	0.3	0.9	0.6	0.4	-0.1	0.6	0.3	-0.4	0.2	0.5	-0.7	-1.0
Qualifications: NVQ or HND or HNC or equivalent	2.1	2.5	6.1	2.5	1.8	1.7	1.8	1.7	0.3	1.2	-2.2	0.3	0.0
Commuting to job workplace: Car/motor vehicle	1.6	1.9	3.8	-1.0	-1.7	-1.7	-1.3	-1.4	-0.8	-1.6	2.0	-0.8	-0.8
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.8	-0.3	-1.3	-1.3	-1.0	-1.3	-1.0	-0.9	-0.1	-0.9	0.2
Medication: Aspirin	2.3	3.0	6.2	-2.5	-1.8	-1.3	-1.2	-1.8	-2.1	-1.5	2.1	-1.7	-0.7
Supplements: Vitamin C	1.3	1.5	5.1	-1.5	-0.5	-0.2	-1.3	-1.0	-1.3	-1.6	-0.1	-1.0	-2.3
Knee pain experienced in last month	0.5	0.8	5.7	0.5	-0.6	-0.3	0.2	-0.3	-0.3	-0.3	2.4	1.2	0.1
Hypertension (Self-reported)	0.2	0.5	1.6	-1.0	0.1	0.2	0.3	-0.2	-1.3	-0.7	0.9	-0.3	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	2.2	0.4	0.8	-0.3	1.0	0.5	1.5	0.9	-0.2	0.6	-0.4
Illnesses of father: Heart disease	0.9	1.3	3.6	-0.8	-1.1	-1.7	-0.4	-0.7	0.4	-0.4	1.9	-1.8	-0.9
Illnesses of siblings: Diabetes	0.8	1.0	2.1	0.8	1.0	0.2	1.4	1.2	1.0	1.0	1.4	0.8	0.2
Smoking status: Previous	0.5	0.7	4.3	-0.3	-0.8	-0.1	-0.6	-0.4	-2.1	0.1	0.9	0.6	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.7	-0.7	0.2	-0.2	0.7	0.8	-1.6	0.9	-1.6	0.0	-0.0
Whole body fat-free mass	0.3	2.0	6.4	-2.0	-0.4	-1.6	-0.7	-0.9	2.5	-0.7	-0.2	-0.4	-2.1
Leg fat-free mass (right)	0.3	1.8	5.0	-2.1	-0.4	-1.5	-0.9	-1.0	2.2	-0.8	-0.2	-0.1	-2.0
Arm fat percentage (left)	0.7	2.7	7.7	-2.0	-1.1	-0.8	-1.2	-1.2	2.3	-1.2	2.8	-0.0	-1.8
Average weekly red wine intake	2.1	3.1	5.6	1.1	1.4	2.3	2.1	2.4	-2.0	2.1	0.3	0.8	1.8
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.8	0.4	-0.1	-0.7	0.5	0.2	0.2	0.3	-1.0	1.1	1.3
Mood swings	0.3	0.5	2.8	-0.1	1.4	0.1	0.3	0.1	-1.7	-0.1	-0.4	-0.2	-0.5
Loneliness, isolation	1.2	1.6	3.1	-1.5	-1.7	-1.8	-1.7	-1.7	0.2	-1.3	-0.2	0.2	-0.7
Long-standing illness, disability or infirmity	0.4	0.7	2.5	-1.6	-0.4	-0.8	-0.4	-0.6	0.8	-0.3	0.0	-0.6	-1.4
Ever had bowel cancer screening	1.2	1.4	4.1	-1.1	-0.7	-0.6	-1.3	-1.3	-1.6	-1.4	0.6	-2.0	-0.3
Diabetes diagnosed by doctor	0.2	0.3	1.7	-0.8	0.0	-0.1	0.3	0.4	-0.1	0.8	-0.2	1.3	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.3	-0.3	1.0	0.5	0.8	1.1	-0.8	1.1	-0.7	-0.2	-0.3
Friendships satisfaction	0.6	0.7	2.8	-0.4	-1.3	-0.9	-0.7	-0.7	0.7	-0.3	1.7	-0.5	0.4
Qualifications: nursing, teaching	1.3	2.0	10.2	0.1	-0.1	1.6	-0.3	0.4	-1.8	0.4	-1.8	0.1	3.2
Commuting to job workplace: Walk	4.2	4.6	7.7	2.8	2.4	2.7	2.5	2.5	-0.7	2.0	-0.8	2.0	2.0
Eye problems/disorders: Cataract	0.3	0.3	2.4	0.1	0.5	0.4	0.0	-0.2	-1.5	-0.2	0.2	-0.1	0.5
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	2.4	0.5	0.4	0.6	1.5	0.8	-0.3	1.0	1.1	0.3	-0.1
Medication for cholesterol	0.2	0.4	1.8	0.1	-0.2	-0.3	-0.4	0.2	-0.4	0.7	-0.9	0.3	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	2.9	-1.7	-0.3	-0.6	-1.2	-1.0	-0.6	-1.3	0.5	-1.0	-1.5
Back pain experienced in last month	0.7	1.0	5.3	-2.3	-0.8	-1.1	-1.0	-1.0	-0.3	-0.4	-0.3	-0.7	0.8
Mineral and other dietary supplements	0.7	0.9	2.8	0.4	0.3	0.2	0.8	0.7	0.9	1.0	-0.4	1.7	1.7
Breast cancer (self-reported)	1.1	1.3	2.8	1.6	1.2	1.7	1.4	1.5	-0.3	0.9	1.0	0.5	-0.1
Asthma (self-reported)	0.2	0.4	2.5	-0.9	-0.1	-0.4	-0.2	0.1	-0.1	0.2	-1.6	-0.7	0.0
Osteoporosis (self-reported)	0.2	0.3	0.9	0.7	0.1	0.2	0.1	-0.0	-0.8	-0.0	-1.0	-0.2	0.9
Osteoarthritis (self-reported)	0.2	0.3	1.1	-0.8	0.8	0.2	0.4	0.2	-1.1	0.3	-0.1	0.2	0.2
Medication: Aspirin	3.1	4.1	8.2	-2.9	-2.1	-1.6	-1.5	-2.1	-2.3	-1.8	2.3	-1.7	-1.4
Medication: Gliclazide	1.4	1.6	5.6	-2.4	-1.6	-1.7	-1.1	-1.4	0.2	-0.7	1.0	-0.7	0.1
Illnesses of father: None of the above (group 1)	1.3	1.6	6.4	0.7	1.9	1.6	1.0	1.0	0.3	0.4	-2.5	0.2	-0.1
Smoking status: Current	0.5	0.7	1.2	-1.1	-0.6	-1.1	-1.0	-1.0	0.4	-0.6	-0.3	-0.9	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	2.7	1.6	0.8	0.7	0.1	-0.0	-0.3	-0.4	-0.1	-0.8	-0.3
Whole body water mass	0.3	1.8	6.5	-1.9	-0.2	-1.4	-0.6	-0.7	2.6	-0.6	-0.2	-0.3	-2.1
Leg predicted mass (right)	0.3	1.8	5.0	-2.1	-0.3	-1.5	-0.9	-0.9	2.2	-0.8	-0.3	-0.2	-2.0
Arm fat mass (left)	0.7	3.0	8.3	-2.3	-1.1	-1.1	-1.1	-1.1	2.9	-1.1	2.6	0.2	-1.9
Number of self-reported non-cancer illnesses	0.3	0.5	2.2	-1.5	0.9	-0.1	0.4	0.1	-0.3	0.0	0.8	-0.3	-1.0
Average weekly champagne plus white wine intake	1.0	1.4	4.5	1.4	0.8	2.1	0.7	0.8	-0.6	0.7	1.8	0.8	0.6
Miserableness	0.2	0.4	1.3	-0.5	0.6	0.3	0.2	-0.1	-1.1	-0.3	0.1	-0.7	-1.1
Guilty feelings	0.5	0.8	1.9	-0.1	0.9	0.7	-0.6	-0.5	-0.6	-1.2	-1.0	-1.0	-1.4
Wears glasses or contact lenses	0.8	1.0	4.7	-1.2	-0.6	-0.9	0.2	-0.3	2.2	-0.1	-0.3	-1.4	-0.0
Ever taken oral contraceptive pill	1.2	1.3	4.2	-1.1	0.5	-0.1	0.0	0.1	1.9	-0.3	-2.0	-1.6	-1.2
Hearing aid user	0.5	0.6	1.9	-0.5	-0.7	-0.4	-0.1	-0.5	-0.4	-0.9	1.4	-0.9	-0.9
Mother’s age at death	0.4	0.5	1.8	1.0	-1.0	-0.0	-0.5	-0.3	0.0	-0.4	1.4	0.7	0.6
Financial situation satisfaction	1.3	1.6	9.1	-1.3	-0.5	-1.0	-0.4	-0.7	3.0	-0.9	-0.5	-1.3	-0.6
Tinnitus: Yes, now most or all of the time	2.9	3.4	7.1	-1.5	-1.2	-2.0	-2.5	-2.6	0.2	-2.7	-0.2	-1.2	-2.2
Commuting to job workplace: Public transport	2.0	2.4	7.2	1.8	2.7	2.1	1.3	1.7	0.2	1.5	-1.4	0.4	-0.2
Eye problems/disorders: Glaucoma	3.1	3.7	6.1	2.3	2.0	2.5	2.4	2.3	-0.1	1.8	2.3	1.3	-0.3
Medication: Blood pressure	0.2	0.4	1.0	-0.1	1.0	1.0	0.9	0.8	-0.0	0.3	0.5	0.8	0.2
Pain type(s) experienced in last month: Hip pain	0.8	1.1	2.0	-0.7	-0.4	-1.1	-1.0	-1.4	1.1	-1.1	-1.4	-1.0	-0.4
Supplements: Fish oil (including cod liver oil)	0.6	0.7	3.1	-0.4	0.1	-0.1	-0.6	-0.5	-0.7	-0.8	0.4	-1.5	-1.8
High cholesterol (Self-reported)	0.2	0.4	2.6	-1.6	0.5	-0.1	0.1	0.1	-0.1	0.2	0.7	-0.0	-0.5
Medication: Bendroflumethiazide	0.2	0.3	1.0	-1.0	0.6	0.3	0.4	0.1	-0.8	0.0	0.2	0.6	-0.2
Medication: Paracetamol	1.3	2.1	6.2	-0.9	-1.2	-1.5	-1.0	-1.3	0.1	-1.2	2.5	-1.5	-1.9
Medication: Lisinopril	0.2	0.2	1.1	-0.1	0.3	0.3	0.1	0.1	-0.9	-0.0	1.1	-0.3	0.0
Medication: Atorvastatin	1.2	1.5	2.8	-1.6	-1.7	-0.9	-1.2	-1.2	0.7	-1.1	0.4	-1.0	-1.6
Illnesses of father: High blood pressure	2.8	3.5	6.4	-1.8	-2.3	-2.5	-2.1	-2.3	-1.1	-1.8	1.6	-1.2	-1.2
Alcohol drinker status: Never	1.2	1.4	3.0	-1.2	-1.3	-0.9	-1.7	-1.7	-0.3	-1.4	-1.5	0.0	0.0
Ever smoked	0.5	0.9	4.2	-1.5	-0.6	-0.1	-0.8	-0.5	-2.1	0.0	1.0	0.3	-0.5
Basal metabolic rate	0.4	2.0	6.8	-2.1	-0.4	-1.5	-0.8	-0.9	2.6	-0.7	0.2	-0.3	-2.1
Leg fat percentage (left)	0.8	2.9	15.3	-2.0	-1.2	-0.8	-0.7	-0.9	1.9	-1.1	3.9	0.5	-1.2
Arm fat-free mass (left)	0.5	2.3	6.9	-2.3	-0.5	-1.4	-0.7	-1.0	2.6	-1.1	0.6	-0.4	-2.3
Number of operations (self-reported)	2.0	2.9	7.9	-1.9	-0.7	-1.9	-1.2	-1.5	-0.1	-2.0	-0.4	-2.4	-2.8
Average weekly beer plus cider intake	2.6	3.7	8.6	-2.5	-2.0	-2.9	-2.5	-2.2	0.0	-1.7	-1.2	-0.7	-1.5
Irritability	1.8	3.0	15.0	-1.5	-1.7	-1.6	-1.4	-1.3	-3.9	-0.3	1.7	0.6	0.5
Risk taking	0.9	1.4	8.9	0.4	-1.0	-1.0	-0.7	-0.5	-3.0	-0.4	0.5	0.1	-1.1
Ever had prostate specific antigen (PSA) test	2.7	3.1	6.8	1.9	0.9	1.9	1.9	2.0	-2.0	2.0	2.6	0.5	0.9
Fractured/broken bones in last 5 years	1.2	1.6	3.0	-1.3	-0.5	-1.5	-1.1	-1.1	-1.7	-1.3	-1.0	-1.1	-1.5
Age started oral contraceptive pill	0.6	0.8	3.4	-1.9	-0.8	0.3	-1.2	-0.8	-0.5	-1.0	0.4	-0.3	0.6
Diastolic blood pressure, automated reading	0.5	1.6	12.9	0.1	-0.1	0.2	-0.1	-0.0	3.6	-0.3	1.4	-0.8	-0.5
Ever depressed for a whole week	0.8	0.9	5.7	1.1	0.1	-0.0	0.7	0.8	0.3	0.9	2.4	0.5	0.5
Unable to work because of sickness or disability	0.9	1.2	4.4	0.6	1.2	-0.4	1.0	0.6	0.8	1.2	-1.4	2.1	0.6
Commuting to job workplace: Cycle	0.4	0.4	2.5	1.0	-0.4	-0.1	-0.3	0.0	-1.6	0.6	-0.3	-0.0	0.3
Myopia	0.7	1.0	2.1	-0.6	-0.6	-1.1	-1.2	-1.0	1.3	-0.9	-0.1	-1.0	-1.5
Vascular/heart problems diagnosed by doctor	0.1	0.4	1.3	1.1	0.3	0.1	-0.5	0.3	0.8	0.6	-1.1	0.5	0.0
Cholesterol lowering medication	1.0	1.5	3.6	-1.9	-0.9	-1.1	-0.9	-1.2	1.4	-1.4	0.9	-1.0	-1.3
Medication: Omeprazole (e.g. Zanprol)	1.7	2.0	5.8	-2.4	-1.2	-1.4	-2.0	-1.8	-0.2	-1.6	0.5	-0.2	-1.1
Pain experienced in last month	0.2	0.3	2.2	0.3	0.1	0.2	-0.3	-0.3	0.0	-0.5	-1.5	-0.2	0.2
Supplements: Calcium	0.3	0.3	1.6	-0.2	0.7	0.7	0.5	0.3	-0.5	-0.1	0.0	1.3	0.2
Basal cell carcinoma (self-reported)	0.3	0.3	1.2	1.1	-0.1	0.5	0.5	0.4	0.8	-0.0	0.1	-0.0	0.9
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.1	-0.9	-0.8	-0.3	-0.7	-1.1	-1.0	-0.9	0.8	-0.7	0.5
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.6	-0.6	0.9	1.3	0.1	0.6	-0.3	0.8	0.4	-0.0	0.8
Heart disease (siblings)	1.2	1.5	3.3	-1.5	-0.4	-0.8	-1.0	-1.0	1.0	-1.1	1.5	-1.3	-1.8
Alcohol drinker status: Previous	0.4	0.5	2.9	-1.7	-0.3	-0.7	-0.3	-0.4	-0.2	-0.1	-0.7	-0.5	-0.3
Pack years of smoking	3.8	5.6	11.7	0.0	1.6	1.6	2.5	2.5	1.8	3.4	-1.5	3.0	3.4
Impedance of whole body	0.5	2.8	15.6	1.1	-0.5	1.3	0.4	1.0	-3.9	1.3	0.5	1.0	2.1
Leg fat mass (left)	0.9	3.3	9.2	-2.5	-1.3	-1.4	-1.1	-1.3	2.4	-1.3	3.0	0.3	-1.9
Arm predicted mass (left)	0.4	2.1	6.9	-2.2	-0.3	-1.4	-0.5	-0.8	2.6	-1.0	0.7	-0.5	-2.2