TWAS hub - KCTD18

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Spleen	0.2630	0.0980	1.2e-03	0.029	NA	0.028	NA	0.038	6.3e-02	NA	6.5e-02	NA	3.8e-02
2	YFS	Blood	0.0335	0.0108	9.4e-06	0.016	0.015	0.015	0.016	0.012	4.5e-06	7e-06	8.9e-06	3.5e-06	5.7e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bipolar Disorder or Schizophrenia	9.1	22.2	43.6	6.6	-0.9
Reaction Time	8.0	15.2	30.0	5.5	0.7
Schizophrenia (2014)	7.7	16.9	32.7	5.7	-1.0
Bipolar Disorder (2018)	6.2	9.8	18.4	4.3	-1.1
Schizophrenia (2018)	6.1	12.6	25.2	5.0	-0.2
Ever had bowel cancer screening	5.6	6.5	6.6	2.5	2.6
Mean time to correctly identify matches	5.2	9.9	19.4	4.4	0.7
Financial situation satisfaction	5.2	6.5	12.9	0.1	-3.6
Verbal and Numeric Reasoning (VNR)	4.9	11.7	21.3	-4.6	-1.4
Vitamin and mineral supplements	4.6	6.2	9.6	-1.7	-3.1
Medication: Aspirin	4.2	5.6	11.1	-0.3	3.3
Medication: Aspirin	4.0	5.3	10.5	-0.2	3.2
Risk taking	4.0	5.8	6.6	-2.6	2.3
Medication: Simvastatin	3.9	5.8	9.7	1.4	3.1
Irritability	3.7	6.3	8.8	-1.9	-3.0
Number of self-reported non-cancer illnesses	3.6	6.3	7.2	2.3	2.7
Noisy workplace	3.4	4.2	7.3	1.1	2.7
Osteoporosis (self-reported)	3.3	4.1	7.5	-2.7	0.8
Breast Cancer	3.2	7.8	11.7	-2.0	3.4
High cholesterol (Self-reported)	3.2	5.6	6.9	2.6	2.1
Pulse wave peak to peak time	3.1	3.6	7.1	-0.3	-2.7
Mean Putamen Volume	3.0	3.4	5.2	-1.2	2.3
Forced expiratory volume in 1-second (FEV1)	3.0	10.2	16.8	-1.9	-4.1
Intelligence (Savage-Jansen 2018)	2.9	8.9	17.8	-4.2	-0.3
Average weekly red wine intake	2.9	4.2	8.1	-0.6	-2.8
Frequency of tiredness / lethargy in last 2 weeks	2.8	4.5	8.2	0.9	-2.9
Forced expiratory volume in 1-second (FEV1), Best measure	2.8	9.0	17.3	-0.8	-4.2
Fluid intelligence score	2.7	5.6	10.4	-3.2	-0.8
Medication: Omeprazole (e.g. Zanprol)	2.7	3.3	6.4	2.5	0.5
Supplements: Calcium	2.7	3.0	3.2	-1.8	-1.7
Depression (Nagel 2018)	2.6	3.9	5.3	2.3	-1.6
Relative age of first facial hair	2.6	5.4	8.1	-1.6	-2.8
Pulse wave Arterial Stiffness index	2.6	3.1	6.1	0.2	2.5
Medication for pain relief, constipation, heartburn	2.6	4.5	5.5	-1.9	-2.3
Mother’s age at death	2.6	3.3	4.9	-2.2	1.3
Tinnitus: Yes, now most or all of the time	2.6	3.0	5.4	-0.8	2.3
Frequency of unenthusiasm / disinterest in last 2 weeks	2.5	3.4	3.8	1.7	-1.9
Qualifications: CSEs or equivalent	2.5	3.3	6.2	0.6	-2.5
Forced vital capacity (FVC)	2.4	9.3	13.8	-2.2	-3.7
Gout (self-reported)	2.4	3.3	4.8	-2.2	-1.4
Alcohol intake frequency.	2.4	5.6	8.9	1.5	3.0
Primary Biliary Cirrhosis	2.3	3.2	3.7	1.9	1.7
Worrier / anxious feelings	2.3	4.4	8.5	2.9	-0.6
Medication: Cholesterol lowering	2.3	3.5	7.0	0.2	2.6
Peak expiratory flow (PEF)	2.3	5.3	8.3	-1.5	-2.9
Illnesses of father: High blood pressure	2.3	2.9	4.7	2.2	1.0
Unable to work because of sickness or disability	2.3	3.0	3.6	1.9	1.5
Number of treatments/medications taken	2.2	4.0	4.7	1.8	2.2
Supplements: Glucosamine	2.2	2.8	4.1	-1.2	2.0
Hair/balding pattern: Pattern 2	2.2	2.8	5.6	2.4	0.2
Lung cancer (father)	2.2	2.6	3.0	1.7	1.5
Qualifications: O levels/GCSEs or equivalent	2.2	3.5	6.5	-2.6	0.7
Qualifications: None of the above	2.1	4.5	6.0	1.8	2.5
Mouth/teeth dental problems: Bleeding gums	2.1	2.7	3.0	-1.7	-1.6
Medication: Omeprazole	2.1	2.6	5.1	2.3	-0.1
Supplements: Vitamin C	2.1	2.5	4.2	0.9	2.1
Medication: Lisinopril	2.1	2.7	3.7	1.9	1.3
Townsend deprivation index at recruitment	2.0	2.8	5.6	2.4	0.2
Multivitamins +/- minerals	2.0	2.6	3.7	1.9	1.2
Breastfed as a baby	2.0	2.5	3.3	-1.8	-1.3
Pulse wave reflection index	2.0	2.5	3.7	1.1	1.9
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.3	3.3	1.8	-1.1
Medication: Allopurinol	2.0	2.6	5.1	-2.2	-0.5
Suffer from ‘nerves’	2.0	3.1	6.0	2.5	-0.5
Commuting to job workplace: Public transport	2.0	2.4	4.8	0.3	-2.2
Commuting to job workplace: Cycle	2.0	2.4	3.4	-1.1	-1.9
Angina	1.9	2.5	2.7	1.5	1.6
Average weekly fortified wine intake	1.9	2.2	2.9	-1.2	1.7
Bilateral oophorectomy (both ovaries removed)	1.9	2.2	4.1	2.0	-0.5
Number of live births	1.9	2.7	5.2	0.4	2.3
Medication for cholesterol, blood pressure or diabetes	1.9	3.1	5.0	-1.1	-2.2
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.2	4.4	0.3	2.1
Bipolar Disorder (2011)	1.8	1.7	2.7	1.6	0.9
Fed-up feelings	1.8	3.3	4.6	1.4	-2.1
Forced vital capacity (FVC), Best measure	1.8	6.4	11.8	-1.0	-3.4
Migraine (self-reported)	1.8	2.3	2.5	-1.6	1.4
Smoking status: Current	1.8	2.9	5.8	-2.4	0.1
Supplements: Fish oil (including cod liver oil)	1.8	2.3	4.1	0.7	2.0
Alcohol drinker status: Never	1.8	2.2	4.0	-0.6	2.0
Alcohol drinker status: Previous	1.8	2.0	3.1	1.0	1.8
Age at First Birth	1.7	2.4	4.3	-2.1	0.8
Neuroticism (2016)	1.7	2.4	4.7	0.4	-2.2
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	3.3	1.8	0.6
Current tobacco smoking	1.7	2.8	5.5	-2.3	-0.2
Mouth/teeth dental problems: Loose teeth	1.7	2.0	2.7	-1.1	-1.6
Irritable Bowel Disease (IBD)	1.6	3.8	6.8	2.6	-0.9
Coronary Artery Disease (CAD)	1.6	1.9	3.7	-1.9	-0.4
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.4	3.9	2.0	-1.0
Time employed in main current job	1.6	1.8	3.6	-0.1	1.9
Number of full brothers	1.6	2.0	3.9	-0.3	-2.0
Angina (self-reported)	1.6	2.2	2.5	1.4	1.6
Loneliness, isolation	1.6	2.2	4.2	0.6	-2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	3.7	1.9	0.2
Osteoarthritis (self-reported)	1.6	2.0	4.1	-0.1	2.0
Hypothyroidism (self reported)	1.5	3.4	6.7	2.6	-0.2
Sensitivity / hurt feelings	1.5	2.5	3.6	-1.9	-1.2
Frequency of depressed mood in last 2 weeks	1.5	2.1	3.6	0.8	-1.9
Age when periods started (menarche)	1.5	3.5	6.9	2.6	0.5
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	3.0	-0.4	-1.7
Exposure to tobacco smoke at home	1.5	1.6	1.8	1.2	-1.4
Medication: Ventolin 100micrograms inhaler	1.5	1.9	3.6	1.9	0.3
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.2	5.5	-1.0	-2.3
Ever smoked	1.5	2.7	5.3	-2.3	-0.0
Worry (Nagel 2018)	1.4	3.0	5.9	2.4	-0.4
Smoking Status	1.4	3.4	6.7	-2.6	-0.2
Respiratory disease	1.4	3.1	5.5	2.4	-0.9
Hypothyroidism/myxoedema (self-reported)	1.4	2.8	5.3	2.3	0.5
Crohns Disease (2017)	1.3	2.9	5.6	2.4	0.4
Ulcerative Colitis (UC)	1.3	2.4	2.6	1.5	-1.6
LDL Cholesterol	1.3	2.0	2.5	-1.6	1.2
Rheumatoid Arthritis	1.3	1.8	3.3	0.5	-1.8
Number of incorrect matches in round	1.3	2.2	2.8	1.7	1.2
Pulse rate	1.3	2.2	2.4	-1.6	-1.4
Qualifications: A levels/AS levels or equivalent	1.3	2.8	5.3	-2.3	0.6
Depression (self-reported)	1.3	1.6	2.3	1.5	-0.9
Hair/balding pattern: Pattern 4	1.3	3.1	4.6	-1.2	2.2
Blood clot in the leg (DVT)	1.3	1.7	2.1	-1.1	1.5
Glaucoma (self-reported)	1.3	1.6	2.0	1.4	1.1
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	2.1	1.5	1.4
Cholesterol lowering medication	1.3	1.9	2.3	1.5	1.2
Basal cell carcinoma (self-reported)	1.3	1.5	2.9	-1.7	0.4
Ever had hysterectomy (womb removed)	1.2	1.4	1.8	1.3	1.0
High blood pressure (mother)	1.2	1.7	1.9	1.4	1.2
Had menopause	1.2	1.6	1.7	1.3	1.2
Comparative body size at age 10	1.2	3.4	5.5	-2.4	-1.1
Number of children fathered	1.2	1.3	2.7	-1.6	-0.1
Friendships satisfaction	1.2	1.5	2.9	0.2	-1.7
Ever taken oral contraceptive pill	1.2	1.3	2.5	-0.4	-1.6
Ever had prostate specific antigen (PSA) test	1.2	1.3	2.5	1.6	0.4
Pain experienced in last month	1.2	2.0	2.1	-1.4	-1.4
Pack years of smoking	1.2	1.8	2.8	-0.9	1.7
Lung FVC	1.1	5.6	7.9	-1.8	-2.8
Stomach or abdominal pain in last month	1.1	1.4	2.6	1.6	0.5
Medication: Atorvastatin	1.1	1.4	1.6	1.1	1.2
Ever depressed for a whole week	1.1	1.3	1.8	-0.9	-1.4
Deep venous thrombosis (DVT) (self-reported)	1.1	1.5	1.7	-1.3	1.1
Lupus	1.0	1.5	2.4	0.7	1.6
Systolic Blood Pressure	1.0	5.0	8.8	3.0	-1.1
Medication: Co-codamol	1.0	1.2	1.9	0.7	-1.4
Pack years adult smoking proportion	1.0	1.6	1.9	-1.4	1.1
Father’s age at death	1.0	1.3	1.5	1.0	1.2
Asthma	1.0	1.9	2.0	1.3	-1.4
Prospective memory result	1.0	1.2	1.8	1.3	0.7
Leg fat-free mass (right)	1.0	5.3	9.5	-3.1	-1.0
Asthma (self-reported)	1.0	2.0	2.2	1.5	-1.3
Nervous feelings	0.9	1.7	2.6	1.6	-0.9
Hearing difficulty/problems with background noise	0.9	1.4	2.7	-1.6	0.3
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	1.9	1.4	0.6
Alcohol intake versus 10 years previously	0.9	1.4	2.3	1.5	0.7
Chronic bronchitis/emphysema (mother)	0.9	1.1	1.5	1.2	0.8
Exposure to tobacco smoke outside home	0.9	1.2	2.3	1.5	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	2.1	1.5	-0.3
Long-standing illness, disability or infirmity	0.9	1.3	2.1	1.4	0.7
Mineral and other dietary supplements	0.9	1.1	2.2	0.3	-1.5
Breast cancer (self-reported)	0.9	1.1	1.7	0.8	-1.3
Medication: Gliclazide	0.9	1.0	1.8	-0.5	1.3
Leg predicted mass (right)	0.9	5.0	9.2	-3.0	-0.9
Eye problems/disorders: Glaucoma	0.9	1.0	1.4	0.8	1.2
Pain type(s) experienced in last month: Hip pain	0.9	1.1	1.2	-1.1	1.0
Fractured/broken bones in last 5 years	0.9	1.1	1.2	1.1	1.0
BMI	0.8	4.9	9.7	-3.1	-0.0
Impedance of leg (right)	0.8	3.9	7.4	2.7	0.6
Leg fat-free mass (left)	0.8	4.4	8.4	-2.9	-0.6
Leg predicted mass (left)	0.8	4.0	7.7	-2.8	-0.5
Past tobacco smoking	0.8	1.5	3.0	1.7	0.2
Neuroticism score	0.8	1.8	3.3	0.5	-1.8
Happiness	0.8	1.0	2.0	0.2	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	2.1	1.5	-0.1
Family relationship satisfaction	0.8	1.0	1.8	0.5	-1.3
Basal metabolic rate	0.8	4.5	8.9	-3.0	-0.2
Number of operations (self-reported)	0.8	1.2	2.3	1.5	0.2
Blood Platelet Count	0.7	8.0	14.6	1.2	3.8
Blood Red Count	0.7	6.3	12.3	-3.5	-0.6
Neuroticism	0.7	1.6	2.7	0.8	-1.6
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.7	1.3	-0.1
Supplements: Zinc	0.7	0.7	1.3	-0.3	-1.2
Body mass index (BMI)	0.7	2.9	5.8	-2.4	0.1
Waist circumference	0.7	2.4	4.7	-2.2	0.3
Weight	0.7	3.5	7.0	-2.6	-0.1
Impedance of arm (right)	0.7	3.1	5.5	2.4	-0.8
Trunk fat-free mass	0.7	4.0	8.0	-2.8	0.2
Emphysema/chronic bronchitis	0.7	0.7	0.9	0.8	1.0
Pulse rate, automated reading	0.7	2.2	2.8	-1.2	-1.7
Whole body fat-free mass	0.7	4.2	8.4	-2.9	-0.2
Mood swings	0.7	1.2	1.6	0.9	-1.3
Medication for cholesterol	0.7	1.0	2.0	-0.3	-1.4
Whole body water mass	0.7	3.9	7.8	-2.8	-0.2
Arm fat-free mass (left)	0.7	3.3	6.6	-2.6	0.1
Vascular/heart problems diagnosed by doctor	0.7	1.9	2.6	-1.6	-1.1
Impedance of whole body	0.7	3.8	7.6	2.8	-0.0
Alzheimer’s Disease (in mother)	0.6	0.7	1.3	-0.3	1.2
Ulcerative Colitis	0.6	0.9	1.2	1.1	-0.8
High blood pressure	0.6	1.7	2.9	1.7	0.8
Impedance of leg (left)	0.6	3.0	5.9	2.4	0.4
Pain all over the body in last month	0.6	0.6	1.1	1.0	-0.4
Trunk predicted mass	0.6	3.7	7.3	-2.7	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.5	1.2	-0.5
Loud music exposure frequency	0.6	0.6	1.1	-1.1	0.3
Medication: Paracetamol	0.6	1.0	1.9	1.4	0.2
Arm fat-free mass (right)	0.6	3.2	6.4	-2.5	0.1
Arm predicted mass (right)	0.6	3.3	6.6	-2.6	0.0
Age at last live birth	0.6	0.8	1.7	-1.3	0.1
Hypertension (Self-reported)	0.6	1.7	2.5	1.6	1.0
Arm fat mass (left)	0.6	2.3	4.5	-2.1	-0.0
Medication: Paracetamol	0.6	0.9	1.8	1.3	-0.0
Leg fat mass (left)	0.6	2.5	4.7	-2.2	0.6
Lung FEV1/FVC ratio	0.5	2.4	4.8	-0.0	-2.2
Hand grip strength (left)	0.5	1.2	2.3	-1.5	0.4
Medication: Atenolol	0.5	0.7	1.3	-1.1	0.3
Heart attack	0.5	0.6	1.2	-0.1	-1.1
Medication: Ramipril	0.5	0.6	0.7	0.9	0.7
Falls in the last year	0.5	0.6	0.7	-0.8	0.8
Impedance of arm (left)	0.5	2.4	4.5	2.1	-0.6
Arm fat mass (right)	0.5	2.2	4.4	-2.1	-0.0
Tense / ‘highly strung’	0.5	0.8	1.5	0.3	-1.2
Age at first live birth	0.5	0.9	1.2	-1.1	-0.7
Shortness of breath walking on level ground	0.5	0.6	1.2	-0.1	-1.1
Qualifications: College or University degree	0.5	1.6	2.1	-1.1	-1.5
Medication: Blood pressure	0.5	0.8	1.4	0.6	1.2
Leg fat mass (right)	0.5	2.0	3.5	-1.9	0.7
Illnesses of siblings: Diabetes	0.5	0.6	1.0	0.5	-1.0
Back pain experienced in last month	0.5	0.7	1.2	0.3	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	1.8	1.3	-0.6
Myopia	0.5	0.7	1.4	-0.2	-1.2
Depressed Affect (Nagel 2018)	0.4	0.8	1.2	0.6	-1.1
Alzheimer’s Disease (including proxy)	0.4	0.5	0.7	0.6	0.8
Prostate Cancer	0.4	0.6	1.1	1.1	0.2
HDL Cholesterol	0.4	0.7	0.9	0.9	0.7
Triglycerides	0.4	0.6	0.7	-0.7	0.8
Blood Eosinophil Count	0.4	3.2	6.1	-2.5	-0.5
Waist Hip Ratio (WHR)	0.4	2.0	3.2	-1.8	0.9
Hearing difficulty/problems: Yes	0.4	0.6	1.2	-0.3	1.1
Medication: Levothyroxine sodium	0.4	0.6	1.0	1.0	0.5
Trunk fat mass	0.4	1.5	3.1	-1.8	0.1
Alcohol usually taken with meals	0.4	0.6	1.1	-1.0	-0.4
Had other major operations	0.4	0.5	1.0	1.0	-0.1
Hip circumference	0.4	1.8	3.1	-1.8	-0.7
Hair/balding pattern: Pattern 3	0.4	0.6	1.2	-1.1	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.6	0.8	0.6
Mouth/teeth dental problems: Dentures	0.4	0.6	0.9	0.5	1.0
Worry too long after embarrassment	0.4	0.7	1.3	-1.1	-0.4
Wheeze or whistling in the chest in last year	0.4	0.6	0.9	0.9	-0.6
Whole body fat mass	0.4	1.8	3.5	-1.9	0.3
Knee pain experienced in last month	0.4	0.6	1.0	0.3	1.0
Arm fat percentage (left)	0.4	1.4	2.9	-1.7	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.7	0.3	0.8
Wears glasses or contact lenses	0.4	0.5	0.9	-0.2	-0.9
Medication: Blood pressure	0.4	0.7	1.2	0.5	1.1
Leg fat percentage (left)	0.4	1.3	2.2	-1.5	0.6
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.0	0.1	-1.0
Heart disease (siblings)	0.4	0.5	1.0	0.3	1.0
Arm predicted mass (left)	0.4	2.3	4.5	-2.1	0.1
Neuroticism (Nagel 2018)	0.3	0.7	0.8	0.9	-0.8
Alzheimer’s Disease (in father)	0.3	0.3	0.5	0.2	-0.7
Ovarian Cancer	0.3	0.4	0.7	-0.8	0.2
Cardiovascular Disease	0.3	1.2	1.7	1.3	0.8
Medication: Metformin	0.3	0.4	0.8	-0.1	0.9
Severe depression (siblings)	0.3	0.3	0.6	-0.7	-0.2
Relative age voice broke	0.3	0.4	0.5	-0.7	-0.6
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.5	0.7	-0.3
Financial difficulties in last 2 years	0.3	0.4	0.5	0.5	-0.7
Arm fat percentage (right)	0.3	1.4	2.8	-1.7	-0.1
Medication: Lansoprazole	0.3	0.4	0.6	-0.8	0.4
Leg fat percentage (right)	0.3	1.0	1.0	-1.0	0.9
Health satisfaction	0.3	0.4	0.7	-0.8	-0.5
Eye problems/disorders: None of the above	0.3	0.4	0.7	-0.0	-0.9
Neck or shoulder pain in last month	0.3	0.5	0.9	1.0	0.0
Medication: Seretide 50 evohaler	0.3	0.4	0.4	0.7	-0.6
Heart disease (mother)	0.3	0.4	0.8	0.1	0.9
Overall health rating	0.3	0.7	0.8	0.9	-0.8
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.5	0.7	0.4
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.4	-0.5	-0.6
Qualifications: nursing, teaching	0.3	0.5	0.6	-0.7	0.8
Commuting to job workplace: Walk	0.3	0.3	0.5	-0.7	0.5
Eye problems/disorders: Cataract	0.3	0.3	0.4	-0.6	-0.5
Average weekly champagne plus white wine intake	0.3	0.5	0.8	-0.3	-0.9
Miserableness	0.3	0.4	0.5	0.6	-0.7
Medication: Bendroflumethiazide	0.3	0.5	0.9	1.0	-0.4
Crohns Disease (2012)	0.2	0.3	0.5	0.7	-0.2
HbA1C	0.2	0.3	0.5	-0.1	0.7
Blood White Count	0.2	1.7	2.9	1.7	-0.7
Heel T-Score	0.2	1.2	1.4	1.0	1.2
Chronotype (morning person)	0.2	0.4	0.7	-0.0	-0.8
Average weekly spirits intake	0.2	0.2	0.4	0.0	0.7
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.5	0.3	-0.7
Systolic blood pressure, automated reading	0.2	0.7	0.9	0.9	0.7
Diabetes (father)	0.2	0.3	0.6	-0.1	-0.8
Diabetes (mother)	0.2	0.2	0.4	0.7	0.0
Trunk fat percentage	0.2	0.6	1.2	-1.1	0.1
Hand grip strength (right)	0.2	0.4	0.8	-0.9	0.4
Taking other prescription medications	0.2	0.3	0.3	0.5	0.5
Serious illness, injury or assault to yourself	0.2	0.3	0.6	-0.1	-0.8
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.7	-0.3	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.4	-0.3	0.7
Illnesses of mother	0.2	0.2	0.4	0.0	-0.6
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.4	0.1	-0.7
Headache pain in last month	0.2	0.4	0.8	0.9	-0.2
Body fat percentage	0.2	0.7	1.3	-1.1	0.3
Medication: Ibuprofen	0.2	0.2	0.3	-0.3	0.5
Comparative height size at age 10	0.2	0.9	1.1	-1.1	0.9
Number of full sisters	0.2	0.2	0.2	-0.5	0.4
Had major operations	0.2	0.2	0.4	0.2	-0.6
Smoking status: Previous	0.2	0.3	0.6	-0.8	-0.0
Diabetes diagnosed by doctor	0.2	0.3	0.6	0.1	0.8
Illnesses of father: None of the above (group 1)	0.2	0.2	0.4	-0.6	-0.2
Diastolic blood pressure, automated reading	0.2	0.8	1.4	0.4	1.2
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	0.5	0.1
Type 2 Diabetes (T2D) (2012)	0.1	0.2	0.2	-0.4	-0.4
Hair Pigment	0.1	2.4	3.6	1.1	1.9
Maternal smoking around birth	0.1	0.1	0.2	-0.5	0.0
Sitting height	0.1	0.5	0.8	-0.9	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.1	0.2	-0.4	0.3
Allergy	0.1	0.2	0.2	0.4	0.4
Diabetes (self-reported)	0.1	0.1	0.2	0.0	0.4
Illnesses of siblings	0.1	0.1	0.2	-0.1	0.5
Length of working week for main job	0.1	0.1	0.2	-0.4	-0.4
Birth weight	0.1	0.1	0.2	-0.5	-0.0
High blood pressure (siblings)	0.1	0.1	0.1	0.3	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.3	0.2	-0.5
Chest pain or discomfort	0.1	0.2	0.2	0.4	-0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	0.3	0.3
Hearing aid user	0.1	0.1	0.1	0.1	0.4
Average weekly beer plus cider intake	0.1	0.1	0.1	0.4	-0.2
Major Depression (MDD)	0.0	0.0	0.1	-0.2	-0.1
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	0.1	-0.1
Fasting Glucose	0.0	0.0	0.0	-0.1	0.1
Height	0.0	0.1	0.3	0.1	0.5
Allergy or Eczema	0.0	0.1	0.1	-0.0	0.4
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.1	0.0	0.3
Tanning	0.0	0.5	0.5	-0.6	-0.7
Medication for hormone replacement therapy	0.0	0.0	0.1	0.3	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.0	0.0	-0.1	0.0
Chronic bronchitis/emphysema (father)	0.0	0.0	0.0	-0.1	0.1
Ever unenthusiastic/disinterested for a whole week	0.0	0.1	0.1	0.3	-0.1
Mouth/teeth dental problems	0.0	0.0	0.0	0.0	0.0
Standing height	0.0	0.4	0.7	-0.8	-0.3
Birth weight of first child	0.0	0.1	0.1	0.1	0.4
Medication: Amlodipine	0.0	0.1	0.1	-0.1	0.3
Leg pain on walking	0.0	0.1	0.1	-0.2	0.3
Illnesses of father: Heart disease	0.0	0.0	0.0	-0.0	0.1
Guilty feelings	0.0	0.0	0.0	-0.2	0.1
Age started oral contraceptive pill	0.0	0.0	0.0	0.1	0.1

Hub : Genes

KCTD18

Models

Trait associations