Best TWAS P=1.91e-09 · Best GWAS P=6.32e-09 conditioned to 0.142
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FAM175A | 0.06 | 0.06 | enet | 7 | 0.06 | 8.9e-08 | -5.4 | 5.7 | 1.1e-08 | 0.98 | 0.01 | 0.99 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | MRPS18C | 0.15 | 0.12 | enet | 11 | 0.13 | 4.8e-15 | -5.4 | -5.9 | 4.0e-09 | -0.91 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Muscle Skeletal | MRPS18C | 0.09 | 0.03 | lasso | 3 | 0.05 | 9.1e-06 | 3.9 | -5.7 | 1.5e-08 | -0.71 | 0.05 | 0.93 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | MRPS18C | 0.14 | 0.12 | enet | 14 | 0.08 | 2.6e-07 | 5.8 | 5.2 | 1.5e-07 | 0.96 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Testis | HELQ | 0.15 | 0.10 | enet | 12 | 0.08 | 2.3e-04 | 5.5 | 5.3 | 1.3e-07 | 0.98 | 0.02 | 0.98 | FALSE |
| 6 | NTR | Blood | MRPS18C | 0.06 | 0.05 | lasso | 7 | 0.04 | 7.8e-14 | -5.4 | -5.8 | 8.6e-09 | -0.97 | 0.01 | 0.99 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MRPS18C | 0.05 | 0.03 | enet | 9 | 0.06 | 3.2e-13 | 5.8 | -5.8 | 7.3e-09 | -0.86 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Colon Adenocarcinoma | MRPS18C | 0.09 | 0.06 | blup | 29 | 0.08 | 3.0e-05 | 5.7 | -5.7 | 1.4e-08 | -0.84 | 0.00 | 0.98 | FALSE |
| 9 | The Cancer Genome Atlas | Glioblastoma Multiforme | MRPS18C | 0.16 | 0.05 | blup | 29 | 0.08 | 2.7e-03 | 5.7 | -5.8 | 5.1e-09 | -0.83 | 0.00 | 0.82 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MRPS18C | 0.22 | 0.11 | lasso | 5 | 0.12 | 2.7e-13 | 3.9 | -5.3 | 8.7e-08 | -0.65 | 0.97 | 0.03 | FALSE |
| 11 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | MRPS18C | 0.19 | 0.08 | enet | 10 | 0.12 | 1.6e-07 | 5.8 | -5.6 | 1.9e-08 | -0.86 | 0.00 | 1.00 | FALSE |
| 12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MRPS18C | 0.19 | 0.14 | enet | 11 | 0.20 | 8.3e-23 | 5.8 | -5.6 | 1.7e-08 | -0.82 | 0.00 | 1.00 | FALSE |
| 13 | The Cancer Genome Atlas | Lung Adenocarcinoma | MRPS18C | 0.07 | 0.02 | lasso | 4 | 0.05 | 2.7e-06 | 5.7 | -5.9 | 3.3e-09 | -0.80 | 0.01 | 0.98 | FALSE |
| 14 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | MRPS18C | 0.10 | 0.12 | enet | 7 | 0.09 | 1.6e-04 | 5.7 | -6.0 | 2.7e-09 | -0.98 | 0.00 | 0.99 | FALSE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MRPS18C | 0.28 | 0.08 | lasso | 4 | 0.17 | 4.6e-17 | 3.9 | -5.9 | 3.5e-09 | -0.78 | 0.02 | 0.98 | FALSE |
| 16 | The Cancer Genome Atlas | Soft Tissue Sarcoma | MRPS18C | 0.06 | 0.02 | blup | 29 | 0.03 | 1.0e-02 | 5.8 | -5.7 | 1.2e-08 | -0.79 | 0.01 | 0.64 | FALSE |
| 17 | The Cancer Genome Atlas | Thyroid Carcinoma | MRPS18C | 0.16 | 0.09 | enet | 8 | 0.20 | 4.4e-19 | 5.8 | -6.0 | 1.9e-09 | -0.83 | 0.00 | 1.00 | TRUE |