Hub : Genes

FAM175A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0560	0.0170	1.5e-05	0.065	0.035	0.060	0.036	0.022	2.6e-08	3.7e-05	8.9e-08	3e-05	0.00099
2	GTEx	Cells Transformed fibroblasts	0.2280	0.0850	6.9e-03	0.012	NA	0.053	NA	0.029	4.2e-02	NA	7.5e-05	NA	0.00270
3	TCGA	Brain Lower Grade Glioma	0.0247	0.0174	1.4e-03	0.028	0.026	0.019	NA	0.028	3.3e-04	5.2e-04	2.9e-03	NA	0.00036

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.4	0.6	0.8	0.6	-0.8	-0.9
Bipolar Disorder or Schizophrenia	0.0	0.1	0.2	-0.5	0.2	0.1
Depressed Affect (Nagel 2018)	0.0	0.1	0.1	-0.2	0.3	0.3
Depression (Nagel 2018)	0.5	0.8	1.7	0.3	-1.3	-0.7
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.7	-0.7	-0.8	0.3
Neuroticism (Nagel 2018)	0.1	0.2	0.6	-0.2	-0.8	0.3
Schizophrenia (2018)	0.4	0.8	1.1	-1.1	0.9	0.8
Schizophrenia vs Biploar Disorder	0.9	1.2	1.8	-1.1	1.3	0.8
Worry (Nagel 2018)	0.5	1.1	1.2	1.0	-1.0	-1.1
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	0.4	-0.3	0.2
Alzheimer’s Disease (in father)	0.3	0.3	0.9	0.1	0.9	-0.2
Alzheimer’s Disease (including proxy)	0.2	0.3	0.5	0.7	0.5	-0.5
Crohns Disease (2017)	1.1	2.4	3.1	1.6	1.3	-1.8
Irritable Bowel Disease (IBD)	1.3	3.0	7.6	0.7	2.8	-1.0
Ulcerative Colitis (UC)	1.2	2.2	5.5	-0.7	2.3	0.8
Major Depression (MDD)	0.9	1.1	1.5	1.2	0.8	-1.1
Reaction Time	0.6	1.2	2.2	-0.5	-1.5	1.0
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.2	-0.5	0.1	0.2
Breast Cancer	8.1	19.6	32.7	5.7	0.2	-5.1
Ovarian Cancer	0.2	0.2	0.7	-0.1	0.8	0.1
Prostate Cancer	0.1	0.2	0.4	-0.4	-0.6	0.0
Age at First Birth	1.4	2.1	4.0	-1.1	-2.0	1.1
Bipolar Disorder (2011)	0.2	0.2	0.6	0.3	0.0	-0.8
Body Mass Index (BMI) (2010)	0.7	1.0	1.7	-0.5	-1.3	1.0
Coronary Artery Disease (CAD)	0.8	0.9	2.2	0.7	-1.5	0.1
Crohns Disease (2012)	0.1	0.1	0.3	0.1	-0.1	-0.5
Mean Putamen Volume	0.1	0.2	0.3	-0.5	0.2	0.4
Fasting Glucose	1.8	2.2	6.3	0.1	-2.5	-0.5
HbA1C	1.4	1.5	2.8	1.1	0.8	-1.7
HDL Cholesterol	0.8	1.4	2.0	-1.2	1.4	0.9
LDL Cholesterol	3.4	5.5	6.3	-2.3	-2.1	2.5
Lupus	0.2	0.3	0.7	-0.3	0.9	0.1
Neuroticism (2016)	0.0	0.0	0.0	0.1	-0.0	-0.1
Primary Biliary Cirrhosis	0.3	0.4	1.0	-1.0	0.1	0.5
Rheumatoid Arthritis	0.6	0.8	1.2	-0.8	1.1	0.6
Schizophrenia (2014)	0.2	0.5	0.9	-0.9	0.6	0.4
Triglycerides	0.1	0.2	0.3	0.6	0.3	-0.5
Type 2 Diabetes (T2D) (2012)	5.1	5.9	8.9	2.9	-0.6	-3.0
Ulcerative Colitis	0.4	0.5	1.5	0.1	1.2	-0.1
Blood Eosinophil Count	0.0	0.3	0.5	-0.3	0.7	0.5
Blood Platelet Count	0.0	0.2	0.6	-0.7	0.4	0.2
Blood Red Count	0.2	2.2	4.8	0.7	2.2	-1.2
Blood White Count	0.3	2.5	3.6	-1.9	-0.8	1.8
Heel T-Score	0.0	0.1	0.1	-0.2	-0.3	-0.2
BMI	0.0	0.1	0.2	-0.1	0.4	-0.1
Height	0.2	4.3	11.6	0.7	3.4	-1.0
Waist Hip Ratio (WHR)	0.8	3.6	6.6	2.6	-0.9	-1.8
Systolic Blood Pressure	1.3	6.4	11.5	2.8	-0.0	-3.4
Smoking Status	0.0	0.1	0.2	-0.5	0.0	0.3
Allergy or Eczema	0.0	0.0	0.0	0.0	0.1	0.2
Cardiovascular Disease	0.0	0.1	0.2	0.4	0.3	-0.3
Hypothyroidism (self reported)	0.7	1.7	3.1	-1.4	0.2	1.8
Respiratory disease	0.1	0.2	0.4	-0.5	-0.3	0.6
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.6	0.8	0.6	-0.4
Lung FEV1/FVC ratio	1.1	5.7	9.0	-2.6	-1.2	3.0
Lung FVC	0.1	0.3	0.8	-0.3	0.9	0.1
Neuroticism	0.2	0.4	0.6	0.5	-0.7	-0.8
Chronotype (morning person)	0.5	1.2	2.7	-0.1	1.6	0.8
Hair Pigment	0.1	2.9	8.2	0.4	2.9	-0.5
Tanning	0.2	2.6	4.9	2.2	-0.8	-1.5
Hand grip strength (left)	0.6	1.5	4.2	-0.1	-2.0	0.4
Number of treatments/medications taken	0.6	1.1	1.7	1.3	0.0	-1.2
Average weekly spirits intake	1.3	1.6	2.5	1.3	0.8	-1.6
Sensitivity / hurt feelings	0.8	1.3	2.5	-0.8	-1.6	0.8
Frequency of depressed mood in last 2 weeks	0.4	0.5	0.9	0.8	-0.2	-1.0
Hearing difficulty/problems: Yes	0.1	0.1	0.3	-0.1	-0.6	0.3
Relative age of first facial hair	1.2	2.4	4.1	1.0	2.0	-1.4
Other serious medical condition/disability diagnosed by doctor	3.8	4.9	7.7	2.8	0.6	-2.6
Ever used hormone-replacement therapy (HRT)	8.9	11.3	14.4	-3.5	-2.8	3.8
Ever had hysterectomy (womb removed)	1.1	1.2	1.7	1.2	0.7	-1.3
Systolic blood pressure, automated reading	1.5	4.3	7.0	2.4	-0.5	-2.6
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.3	0.6	0.4	-0.5
Angina	0.9	1.1	1.3	1.1	1.0	-1.1
Medication for hormone replacement therapy	0.8	0.9	1.0	-1.0	1.0	0.9
Vitamin and mineral supplements	1.3	1.8	2.7	-1.6	0.2	1.7
Supplements: Zinc	0.0	0.0	0.0	0.1	0.2	-0.0
Medication: Co-codamol	0.8	0.9	1.3	-1.1	1.1	0.5
Medication: Metformin	0.6	0.9	2.6	0.3	1.6	-0.2
Diabetes (father)	1.6	2.0	4.2	2.1	-0.5	-1.2
Diabetes (mother)	1.1	1.4	2.0	-1.1	-1.4	1.1
Severe depression (siblings)	0.1	0.2	0.2	0.3	0.4	-0.5
Pack years adult smoking proportion	0.8	1.2	2.2	-0.8	-1.5	0.9
Impedance of leg (right)	0.2	0.9	1.8	-0.9	1.3	0.1
Leg fat-free mass (left)	0.1	0.8	1.1	1.1	0.6	-0.9
Trunk fat percentage	0.0	0.1	0.2	-0.3	0.4	-0.3
Hand grip strength (right)	0.1	0.4	0.6	-0.4	-0.6	0.8
Townsend deprivation index at recruitment	0.1	0.2	0.3	0.4	-0.3	-0.6
Current tobacco smoking	0.2	0.3	0.5	0.5	-0.3	-0.7
Average weekly fortified wine intake	1.1	1.3	1.8	1.2	1.4	-0.8
Maternal smoking around birth	0.2	0.4	0.5	-0.7	-0.5	0.6
Fed-up feelings	0.2	0.3	0.5	-0.4	-0.4	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.1	0.1	-0.4	-0.1	0.1
Relative age voice broke	1.4	2.2	4.4	0.8	2.1	-1.2
Taking other prescription medications	0.1	0.2	0.6	0.2	0.8	0.0
Age when periods started (menarche)	0.6	1.4	2.2	1.5	-0.4	-1.4
Bilateral oophorectomy (both ovaries removed)	3.2	3.7	6.2	2.1	0.7	-2.5
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	2.2	-1.0	-1.5	1.0
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.2	-1.1	-0.3	0.8
Qualifications: CSEs or equivalent	0.1	0.2	0.3	-0.3	0.6	0.2
Serious illness, injury or assault to yourself	0.2	0.2	0.6	0.2	-0.7	-0.3
High blood pressure	0.4	1.1	2.1	1.1	0.2	-1.5
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.1	0.4	1.0	-0.1
Multivitamins +/- minerals	0.6	0.7	0.9	0.7	0.9	-0.8
Stomach or abdominal pain in last month	0.2	0.3	0.6	-0.8	0.4	0.1
Supplements: Glucosamine	0.4	0.5	1.1	-0.5	1.1	0.3
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.8	0.4	0.9	-0.7
Medication: Atenolol	1.5	1.9	2.7	1.6	0.8	-1.5
Medication: Levothyroxine sodium	0.9	1.6	3.0	-1.2	-0.6	1.7
Sitting height	1.2	8.6	15.9	2.0	4.0	-2.4
Chronic bronchitis/emphysema (father)	2.2	2.6	6.8	0.8	2.6	-0.5
High blood pressure (mother)	0.9	1.3	3.8	-0.0	-1.9	-0.0
Body mass index (BMI)	0.3	1.2	1.4	-1.2	-1.2	0.8
Impedance of leg (left)	0.1	0.6	1.3	-0.8	1.1	0.0
Leg predicted mass (left)	0.1	0.5	0.8	0.9	0.6	-0.7
Trunk fat mass	0.0	0.2	0.4	-0.1	0.6	-0.4
Waist circumference	0.1	0.3	0.5	0.7	0.1	-0.6
Number of incorrect matches in round	0.2	0.3	0.5	-0.2	-0.6	0.7
Past tobacco smoking	0.4	0.7	1.0	0.9	-1.0	-0.5
Alcohol usually taken with meals	0.3	0.5	1.2	-0.6	0.3	1.1
Nervous feelings	0.5	1.0	2.0	1.0	-0.2	-1.4
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.6	0.5	0.1	-0.8
Hearing difficulty/problems with background noise	0.9	1.5	2.4	1.4	0.1	-1.6
Hair/balding pattern: Pattern 2	0.6	0.8	1.3	-0.5	-1.2	0.8
Had menopause	16.4	20.5	33.8	-5.1	-1.0	5.8
Had other major operations	0.0	0.0	0.1	-0.1	0.2	0.3
Forced vital capacity (FVC)	0.2	0.8	2.3	0.1	1.5	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.4	-0.3	-1.2	0.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	1.4	1.2	-0.5	-0.8
Qualifications: None of the above	0.7	1.6	4.6	-0.2	-2.1	0.2
Financial difficulties in last 2 years	0.7	1.0	2.9	0.1	-1.7	-0.2
Mouth/teeth dental problems	1.1	1.8	2.0	-1.4	-1.2	1.3
Heart attack	1.1	1.4	2.2	0.9	1.5	-1.1
Allergy	0.1	0.3	0.6	-0.5	-0.8	0.1
Pain all over the body in last month	0.2	0.2	0.6	0.8	-0.2	0.0
Diabetes (self-reported)	0.4	0.6	1.6	0.4	1.3	-0.1
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	3.4	0.7	1.9	-0.5
Medication: Ramipril	0.0	0.0	0.1	-0.0	-0.1	-0.3
Medication: Simvastatin	0.3	0.5	1.0	-0.7	0.3	1.0
Fluid intelligence score	0.1	0.2	0.5	0.2	-0.7	-0.4
Illnesses of siblings	0.2	0.3	0.6	-0.4	-0.0	0.8
Neuroticism score	0.9	1.8	2.8	1.4	-0.7	-1.7
Weight	0.1	0.3	0.6	0.0	0.8	-0.4
Impedance of arm (right)	0.7	3.2	6.7	1.1	2.6	-1.3
Arm fat percentage (right)	0.0	0.1	0.4	-0.6	-0.2	0.2
Trunk fat-free mass	0.0	0.2	0.3	0.4	0.5	-0.4
Hip circumference	0.1	0.6	1.2	-1.1	0.5	0.6
Time employed in main current job	0.4	0.5	1.2	0.3	1.1	-0.3
Alcohol intake versus 10 years previously	1.8	2.7	3.9	-2.0	1.3	1.5
Father’s age at death	1.7	2.3	2.9	1.5	-1.7	-1.4
Worrier / anxious feelings	0.1	0.2	0.6	0.2	-0.8	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	0.8	-0.6	0.9	0.5
Falls in the last year	1.6	2.2	3.0	-1.5	1.1	1.7
Hair/balding pattern: Pattern 3	0.2	0.3	0.7	0.3	0.8	-0.5
Number of live births	0.9	1.2	2.0	-1.1	-0.7	1.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	0.6	-0.7	0.3	0.7
Pulse rate	0.1	0.1	0.2	0.3	-0.4	-0.1
Happiness	0.1	0.1	0.1	-0.3	0.4	0.2
Noisy workplace	0.2	0.3	0.8	0.2	-0.9	-0.1
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.8	-0.9	0.2	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	0.9	0.9	-0.5	-0.9
Mouth/teeth dental problems: Dentures	2.0	3.4	4.5	1.7	2.1	-1.7
Asthma	0.2	0.5	0.8	-0.8	-0.2	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.0	1.0	0.6	-0.6
Medication: Cholesterol lowering	0.7	1.0	3.0	0.2	1.7	0.1
Depression (self-reported)	0.3	0.4	0.7	-0.5	-0.8	0.3
Medication: Lansoprazole	0.4	0.5	0.8	0.8	0.1	-0.9
Prospective memory result	0.0	0.0	0.0	0.2	-0.1	0.1
Lung cancer (father)	1.7	2.0	2.9	-1.7	-0.3	1.7
Illnesses of mother	0.1	0.1	0.2	-0.4	0.4	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	0.8	-0.9	-0.4	0.9
Pulse wave Arterial Stiffness index	0.3	0.4	1.0	0.2	-1.0	-0.3
Impedance of arm (left)	0.6	2.8	6.8	0.7	2.6	-1.0
Arm fat mass (right)	0.0	0.1	0.2	-0.4	0.2	0.1
Trunk predicted mass	0.0	0.2	0.2	0.3	0.5	-0.3
Standing height	0.9	8.6	14.4	2.4	3.8	-2.4
Length of working week for main job	0.5	0.6	1.0	0.8	-0.3	-1.0
Exposure to tobacco smoke at home	0.9	1.0	2.0	-0.4	-1.0	1.4
Breastfed as a baby	0.9	1.1	1.7	-0.8	1.3	1.0
Tense / ‘highly strung’	0.4	0.7	1.3	1.1	-0.2	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.4	0.8	1.2	-0.9
Hair/balding pattern: Pattern 4	0.8	1.9	3.0	1.3	0.9	-1.7
Birth weight of first child	0.5	0.9	1.6	1.1	0.0	-1.3
Peak expiratory flow (PEF)	0.0	0.1	0.1	0.4	0.1	-0.2
Pulse wave reflection index	0.3	0.3	1.0	0.1	-1.0	-0.0
Ever highly irritable/argumentative for 2 days	1.4	1.7	2.6	-1.6	-0.6	1.5
Loud music exposure frequency	0.4	0.5	1.1	0.5	0.2	-1.1
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	3.1	-0.5	1.8	0.2
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.8	-0.9	-0.3	0.6
Blood clot in the leg (DVT)	1.3	1.7	2.1	1.2	1.4	-1.2
Medication: Paracetamol	1.0	1.6	2.3	1.5	-0.9	-1.4
Headache pain in last month	1.2	2.0	3.7	-1.0	-1.9	1.2
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	1.8	-1.3	-0.7	1.3
Glaucoma (self-reported)	0.3	0.3	0.7	0.2	0.8	-0.5
Gout (self-reported)	1.7	2.4	4.0	1.3	2.0	-1.3
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	1.8	-1.0	0.1	1.3
Medication: Amlodipine	2.4	3.4	4.8	-1.8	-2.2	1.5
Medication: Ventolin 100micrograms inhaler	1.8	2.3	3.3	-1.8	0.7	1.8
Birth weight	0.9	1.9	5.4	-0.5	2.3	0.1
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.0	-0.3	1.4	-0.1
High blood pressure (siblings)	0.0	0.0	0.1	-0.2	0.2	0.0
Forced vital capacity (FVC), Best measure	0.0	0.0	0.1	0.0	0.3	-0.1
Body fat percentage	0.0	0.1	0.3	-0.6	-0.0	-0.1
Leg fat percentage (right)	0.3	1.1	1.5	-1.2	-1.2	0.4
Arm fat-free mass (right)	0.0	0.0	0.0	-0.1	-0.1	0.1
Exposure to tobacco smoke outside home	0.3	0.4	0.9	-0.5	0.3	1.0
Comparative body size at age 10	0.6	1.7	2.6	-1.6	0.1	1.6
Number of full brothers	0.3	0.4	0.9	-0.4	1.0	0.3
Worry too long after embarrassment	0.4	0.7	1.3	0.5	-1.2	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.5	3.1	-0.7	-1.8	1.0
Wheeze or whistling in the chest in last year	0.2	0.3	0.8	0.2	0.9	-0.1
Number of children fathered	2.0	2.2	2.6	1.5	-1.6	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	2.2	2.5	3.9	-1.9	0.1	2.0
Age at first live birth	0.0	0.1	0.1	-0.2	0.4	0.1
Pulse wave peak to peak time	0.4	0.5	1.5	-0.1	1.2	0.1
Health satisfaction	0.7	0.9	1.8	-1.3	0.1	0.9
Shortness of breath walking on level ground	0.0	0.1	0.1	-0.3	-0.3	0.1
Qualifications: College or University degree	0.2	0.7	1.8	0.3	1.4	-0.5
Eye problems/disorders: None of the above	0.9	1.1	2.2	0.7	1.5	-0.8
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.7	0.9	-0.3	-0.6
Emphysema/chronic bronchitis	1.5	1.7	2.5	-1.6	-0.6	1.5
Medication for pain relief, constipation, heartburn	0.5	0.8	1.6	-1.2	-0.0	0.9
Neck or shoulder pain in last month	0.3	0.4	1.3	-0.0	1.1	-0.1
Medication: Blood pressure	1.5	2.6	4.0	1.6	1.0	-2.0
Angina (self-reported)	0.8	1.1	1.5	1.1	0.7	-1.2
Migraine (self-reported)	0.2	0.2	0.5	0.4	-0.7	-0.2
Medication: Ibuprofen	0.8	0.9	1.2	1.1	1.1	-0.7
Medication: Allopurinol	1.0	1.3	3.8	0.2	2.0	-0.1
Medication: Omeprazole	0.1	0.1	0.2	0.4	-0.3	-0.1
Medication: Seretide 50 evohaler	0.6	0.7	1.8	-0.2	-1.3	0.5
Mean time to correctly identify matches	0.5	0.9	2.4	-0.1	-1.6	0.6
Heart disease (mother)	0.3	0.4	0.6	0.8	-0.6	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	2.5	1.3	-1.1	-1.6
Whole body fat mass	0.0	0.1	0.2	-0.4	0.3	-0.1
Leg fat mass (right)	0.1	0.3	0.7	-0.8	-0.4	0.3
Arm predicted mass (right)	0.0	0.0	0.0	-0.1	-0.1	0.1
Pulse rate, automated reading	0.1	0.2	0.6	0.2	-0.8	-0.1
Alcohol intake frequency.	0.7	1.5	1.9	-1.3	1.0	1.4
Comparative height size at age 10	0.5	2.6	6.4	0.7	2.5	-0.9
Number of full sisters	0.8	1.0	1.6	1.3	0.5	-1.1
Suffer from ‘nerves’	1.5	2.3	3.7	1.8	-0.1	-1.9
Overall health rating	1.0	2.1	2.6	1.2	1.6	-1.4
Chest pain or discomfort	0.1	0.2	0.4	0.2	0.6	-0.5
Had major operations	1.5	1.8	4.9	0.7	-2.2	-0.0
Age at last live birth	0.3	0.5	1.4	-0.2	1.2	-0.0
Family relationship satisfaction	0.5	0.6	1.1	-1.1	0.0	0.8
Leg pain on walking	0.3	0.4	0.6	0.8	0.5	-0.7
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	3.9	-0.6	2.0	1.0
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.3	-0.0	0.5	-0.5
Illness, injury, bereavement, stress in last 2 years	1.9	2.3	2.8	-1.5	1.7	1.3
Medication: Aspirin	0.1	0.1	0.2	-0.4	-0.4	0.3
Supplements: Vitamin C	2.2	2.6	4.2	1.8	-0.7	-2.1
Knee pain experienced in last month	0.6	0.9	2.6	-0.2	1.6	0.0
Hypertension (Self-reported)	0.4	1.1	2.0	1.1	0.2	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	4.2	0.7	-2.0	-0.5
Illnesses of father: Heart disease	0.6	0.9	1.8	1.3	0.5	-0.7
Illnesses of siblings: Diabetes	2.7	3.3	4.4	2.1	1.1	-2.1
Smoking status: Previous	0.6	0.8	1.8	-0.7	1.4	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.4	0.7	1.2	-0.5
Whole body fat-free mass	0.0	0.3	0.3	0.6	0.4	-0.5
Leg fat-free mass (right)	0.1	0.7	1.2	1.1	0.4	-0.9
Arm fat percentage (left)	0.1	0.2	0.5	-0.7	-0.2	0.3
Average weekly red wine intake	0.2	0.2	0.3	0.6	-0.5	-0.4
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.6	-0.8	0.5	0.6
Mood swings	0.3	0.6	0.8	0.9	0.3	-0.9
Loneliness, isolation	1.5	2.0	3.2	1.6	-0.4	-1.8
Long-standing illness, disability or infirmity	1.3	2.0	6.1	0.3	2.5	-0.1
Ever had bowel cancer screening	0.5	0.5	1.5	-0.3	1.2	0.3
Diabetes diagnosed by doctor	0.1	0.2	0.5	0.1	0.7	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.4	0.8	0.4	-1.2
Friendships satisfaction	2.8	3.5	4.9	-2.2	1.9	1.4
Qualifications: nursing, teaching	0.0	0.0	0.0	-0.1	-0.2	-0.0
Commuting to job workplace: Walk	2.1	2.3	4.4	-1.6	-0.2	2.1
Eye problems/disorders: Cataract	2.5	2.9	3.1	-1.8	-1.7	1.7
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.5	0.7	0.2	-0.7
Medication for cholesterol	0.1	0.2	0.4	0.3	0.6	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.9	0.4	1.4	-0.5
Back pain experienced in last month	3.8	5.5	13.9	-1.1	3.7	1.2
Mineral and other dietary supplements	0.2	0.2	0.6	-0.1	-0.8	0.3
Breast cancer (self-reported)	0.6	0.8	1.3	1.1	-0.3	-0.9
Asthma (self-reported)	0.1	0.2	0.4	-0.6	-0.1	0.6
Osteoporosis (self-reported)	0.7	0.8	1.5	-1.2	0.2	1.0
Osteoarthritis (self-reported)	1.1	1.5	1.8	1.3	1.2	-1.2
Medication: Aspirin	0.5	0.6	0.8	-0.9	-0.8	0.7
Medication: Gliclazide	2.3	2.6	3.8	-1.9	0.5	2.0
Illnesses of father: None of the above (group 1)	2.3	2.9	5.2	-2.3	-0.6	1.8
Smoking status: Current	0.2	0.3	0.4	0.4	-0.5	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.8	3.9	5.6	-2.4	-0.8	2.3
Whole body water mass	0.0	0.2	0.3	0.6	0.4	-0.5
Leg predicted mass (right)	0.1	0.7	1.1	1.1	0.3	-0.9
Arm fat mass (left)	0.1	0.2	0.5	-0.7	0.0	0.3
Number of self-reported non-cancer illnesses	0.0	0.0	0.1	0.1	-0.0	0.2
Average weekly champagne plus white wine intake	0.2	0.3	0.4	0.6	-0.6	-0.4
Miserableness	0.1	0.3	0.5	0.4	-0.3	-0.7
Guilty feelings	0.5	0.8	1.8	0.2	-1.4	-0.7
Wears glasses or contact lenses	0.0	0.0	0.1	-0.0	0.3	-0.2
Ever taken oral contraceptive pill	0.6	0.7	0.9	0.9	-0.5	-0.9
Hearing aid user	0.4	0.4	0.6	0.5	-0.6	-0.8
Mother’s age at death	0.3	0.3	0.8	-0.5	0.9	0.0
Financial situation satisfaction	2.6	3.2	5.2	-2.3	-0.7	2.0
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.8	0.2	0.9	-0.5
Commuting to job workplace: Public transport	0.7	0.9	1.1	-1.0	-0.8	1.0
Eye problems/disorders: Glaucoma	1.2	1.5	3.9	0.3	2.0	-0.7
Medication: Blood pressure	0.3	0.6	1.5	-0.4	-1.2	-0.4
Pain type(s) experienced in last month: Hip pain	1.8	2.2	5.9	-0.7	2.4	0.5
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.4	0.1	0.6	-0.6
High cholesterol (Self-reported)	0.1	0.2	0.3	-0.5	0.3	0.6
Medication: Bendroflumethiazide	0.1	0.1	0.3	-0.5	0.2	-0.0
Medication: Paracetamol	0.6	0.9	1.3	1.2	-0.5	-1.1
Medication: Lisinopril	1.5	1.9	3.8	1.0	-2.0	-1.0
Medication: Atorvastatin	1.4	1.7	2.0	1.4	1.1	-1.4
Illnesses of father: High blood pressure	0.3	0.4	1.1	-0.1	-1.0	-0.2
Alcohol drinker status: Never	1.6	2.0	3.7	0.9	1.9	-1.2
Ever smoked	0.2	0.4	0.6	-0.8	0.7	0.2
Basal metabolic rate	0.0	0.2	0.2	0.4	0.5	-0.5
Leg fat percentage (left)	0.3	1.2	1.9	-1.2	-1.4	0.5
Arm fat-free mass (left)	0.0	0.0	0.0	0.2	-0.1	-0.1
Number of operations (self-reported)	0.1	0.1	0.2	0.4	-0.4	0.1
Average weekly beer plus cider intake	0.5	0.8	1.1	-1.0	-0.6	0.9
Irritability	0.4	0.6	0.9	1.0	0.3	-0.9
Risk taking	5.9	8.6	10.6	3.1	2.4	-3.3
Ever had prostate specific antigen (PSA) test	0.5	0.6	0.9	1.0	0.2	-0.9
Fractured/broken bones in last 5 years	0.7	0.9	1.4	-1.1	-0.6	1.2
Age started oral contraceptive pill	0.8	0.9	2.0	1.4	-0.0	-0.9
Diastolic blood pressure, automated reading	0.5	1.6	2.4	1.3	-0.7	-1.5
Ever depressed for a whole week	2.9	3.6	5.9	2.4	-0.4	-2.2
Unable to work because of sickness or disability	0.7	0.9	1.4	-1.2	0.7	0.9
Commuting to job workplace: Cycle	0.3	0.3	0.6	0.4	0.4	-0.8
Myopia	0.0	0.0	0.1	0.2	-0.2	0.1
Vascular/heart problems diagnosed by doctor	0.5	1.3	2.2	-1.1	-0.7	1.5
Cholesterol lowering medication	0.4	0.6	0.9	-0.6	-0.9	0.8
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.8	0.9	-0.1	-0.7
Pain experienced in last month	0.9	1.5	2.2	1.1	-1.1	-1.5
Supplements: Calcium	0.0	0.0	0.1	-0.0	-0.2	0.2
Basal cell carcinoma (self-reported)	0.0	0.0	0.1	-0.2	0.2	0.2
Heart attack/myocardial infarction (self-reported)	1.1	1.5	2.0	1.0	1.4	-1.2
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	1.8	1.3	1.3	-1.3
Heart disease (siblings)	0.2	0.2	0.6	0.2	-0.8	0.2
Alcohol drinker status: Previous	0.1	0.1	0.1	-0.3	-0.3	0.3
Pack years of smoking	0.9	1.3	2.2	-0.9	-1.5	1.0
Impedance of whole body	0.4	2.0	5.5	0.1	2.4	-0.7
Leg fat mass (left)	0.1	0.4	0.8	-0.9	-0.5	0.3
Arm predicted mass (left)	0.0	0.0	0.0	0.1	0.2	-0.2