Best TWAS P=3.58e-11 · Best GWAS P=1.45e-12 conditioned to 0.0117
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | TLR1 | 0.08 | 0.07 | lasso | 2 | 0.07 | 1.3e-08 | -5.7 | -6.3 | 2.5e-10 | 0.91 | 0.12 | 0.88 | FALSE |
| 2 | GTEx | Breast Mammary Tissue | FAM114A1 | 0.11 | 0.04 | lasso | 3 | 0.05 | 1.0e-03 | -5.7 | -6.0 | 1.6e-09 | 0.65 | 0.24 | 0.32 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | TLR6 | 0.28 | 0.19 | lasso | 5 | 0.17 | 1.7e-12 | -5.5 | 5.5 | 3.3e-08 | -0.79 | 0.97 | 0.03 | FALSE |
| 4 | GTEx | Testis | FAM114A1 | 0.37 | 0.20 | lasso | 7 | 0.20 | 2.2e-09 | -6.0 | -6.5 | 1.1e-10 | 0.81 | 0.52 | 0.46 | FALSE |
| 5 | YFS | Blood | TLR1 | 0.08 | 0.05 | bslmm | 525 | 0.07 | 1.2e-20 | -7.1 | 5.3 | 9.6e-08 | -0.82 | 0.00 | 1.00 | FALSE |
| 6 | YFS | Blood | TLR6 | 0.05 | 0.04 | bslmm | 505 | 0.06 | 1.3e-18 | -5.7 | 5.7 | 1.2e-08 | -0.83 | 0.88 | 0.12 | FALSE |
| 7 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TLR6 | 0.03 | 0.02 | lasso | 2 | 0.01 | 3.5e-02 | -5.5 | 5.6 | 1.7e-08 | -0.78 | 0.05 | 0.13 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TLR1 | 0.04 | 0.03 | lasso | 4 | 0.03 | 8.2e-05 | -6.7 | 6.6 | 3.6e-11 | -0.92 | 0.01 | 0.99 | TRUE |
| 9 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | TLR1 | 0.14 | 0.07 | enet | 12 | 0.10 | 1.7e-05 | -5.2 | 5.8 | 7.0e-09 | -0.81 | 0.20 | 0.75 | FALSE |
| 10 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | TLR1 | 0.13 | 0.13 | enet | 3 | 0.08 | 2.6e-03 | -5.9 | 6.6 | 4.7e-11 | -0.80 | 0.02 | 0.64 | FALSE |