TWAS hub - PTPN22

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0880	0.0230	9.0e-09	0.108	0.079	0.110	0.094	0.119	4.7e-13	7.1e-10	2.7e-13	1.8e-11	2.7e-14
2	GTEx	Brain Cerebellum	0.2550	0.0780	5.7e-04	0.018	NA	0.070	NA	0.063	9.5e-02	NA	4.2e-03	NA	6.4e-03
3	GTEx	Colon Transverse	0.1890	0.0560	2.8e-06	0.155	NA	0.183	NA	0.210	7.9e-08	NA	4.4e-09	NA	2.5e-10
4	GTEx	Pancreas	0.1430	0.0660	4.3e-03	-0.006	NA	0.013	NA	0.000	7.8e-01	NA	8.8e-02	NA	3.2e-01
5	YFS	Blood	0.1741	0.0321	0.0e+00	0.024	0.095	0.089	0.097	0.081	1.8e-08	2.3e-29	1.1e-27	3.8e-30	4.3e-25
6	TCGA	Breast Invasive Carcinoma	0.0184	0.0111	3.3e-03	0.014	0.007	0.005	NA	0.006	6.7e-04	9.6e-03	3.3e-02	NA	1.8e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Hypothyroidism (self reported)	42.9	98.5	240.2	9.5	4.5	10.8	7.0	8.6	15.5
Rheumatoid Arthritis	40.4	55.5	171.6	6.6	4.3	7.4	4.4	5.0	13.1
Hypothyroidism/myxoedema (self-reported)	35.4	69.2	163.8	7.8	4.1	8.9	6.5	7.2	12.8
Medication: Levothyroxine sodium	26.5	44.9	104.0	6.2	3.2	7.2	5.5	5.8	10.2
Taking other prescription medications	6.8	10.6	29.8	3.0	2.7	3.3	2.4	0.3	5.5
Long-standing illness, disability or infirmity	6.3	9.6	30.4	2.7	2.6	2.9	2.1	0.7	5.5
Number of treatments/medications taken	5.0	9.0	22.5	2.0	2.0	2.3	4.0	-1.5	4.7
Other serious medical condition/disability diagnosed by doctor	4.5	5.8	10.1	2.3	2.5	2.5	1.2	2.4	3.2
Worry too long after embarrassment	4.4	7.3	11.8	-2.5	-3.4	-2.6	-3.4	-0.3	-2.8
Angina	3.5	4.7	9.9	1.7	2.0	1.9	1.9	3.2	2.0
Angina (self-reported)	3.5	4.6	14.1	1.4	1.6	1.6	1.7	3.8	2.0
Wears glasses or contact lenses	3.4	3.9	5.8	2.1	2.3	2.0	2.4	1.5	1.2
Illnesses of mother	3.2	4.0	7.5	-2.7	-2.6	-2.5	-0.9	-0.3	1.6
Serious illness, injury or assault to yourself	3.1	3.8	17.8	1.1	0.6	1.2	1.2	-0.6	4.2
Commuting to job workplace: Cycle	3.1	3.8	9.9	-1.4	-2.6	-1.4	-3.1	1.5	-0.3
Reaction Time	3.0	5.6	8.1	-2.3	-1.9	-2.4	-2.8	2.1	-2.5
Tense / ‘highly strung’	2.9	4.8	19.8	-1.2	-4.4	-1.0	-1.7	-0.1	1.8
Crohns Disease (2017)	2.8	6.0	15.1	-2.6	-1.6	-3.0	-0.5	-1.6	-3.9
Blood White Count	2.8	20.6	77.1	-1.6	-0.9	-2.2	-3.2	-5.3	-8.8
Number of incorrect matches in round	2.8	4.6	6.4	2.2	0.2	2.4	2.5	2.5	2.2
Breast Cancer	2.7	6.6	32.0	-0.8	-0.4	-1.3	-1.3	-1.7	-5.7
Diabetes (self-reported)	2.7	4.2	17.1	0.6	0.4	0.8	2.6	0.4	4.1
Crohns Disease (2012)	2.6	4.1	7.2	-2.4	-2.1	-2.7	-0.9	-1.6	-2.1
Allergy or Eczema	2.6	6.9	13.5	-3.5	-0.4	-3.7	-2.2	-2.3	-2.4
Hayfever, allergic rhinitis or eczema	2.6	5.6	9.0	-2.9	-0.3	-3.0	-2.3	-2.2	-2.5
Pulse wave Arterial Stiffness index	2.6	3.0	6.0	-1.6	1.1	-1.8	-1.4	-1.8	-2.5
Alcohol intake frequency.	2.6	6.0	12.5	2.2	2.5	2.4	2.2	1.4	3.5
Medication: Cholesterol lowering	2.5	3.9	13.8	1.2	1.0	1.3	1.7	-1.6	3.7
Medication: Atorvastatin	2.5	3.0	8.8	1.8	1.0	1.9	3.0	1.0	0.9
Supplements: Calcium	2.5	2.8	5.7	1.6	1.1	1.5	2.2	-2.4	0.4
Lupus	2.4	3.6	10.0	1.6	0.2	1.9	0.0	2.3	3.2
Pulse wave peak to peak time	2.4	2.8	5.2	1.5	-1.0	1.7	1.4	2.0	2.3
Overall health rating	2.4	5.1	19.1	1.4	0.6	1.5	2.5	0.8	4.4
Medication: Aspirin	2.4	3.2	5.4	2.2	2.3	2.2	1.2	1.0	1.2
Ever smoked	2.4	4.2	23.2	0.2	-0.1	-0.0	-1.3	-0.0	-4.8
Eye problems/disorders: Diabetes related eye disease	2.3	2.6	4.4	1.5	1.2	1.6	2.1	-0.4	2.1
Birth weight	2.3	4.9	10.9	-2.1	-1.4	-2.2	-2.6	0.5	-3.3
Bilateral oophorectomy (both ovaries removed)	2.2	2.6	5.4	-2.3	-2.2	-2.3	-0.2	0.3	0.1
Hayfever/allergic rhinitis (self-reported)	2.2	2.9	5.1	-1.4	-1.1	-1.5	-2.2	-1.5	-2.3
Mouth/teeth dental problems: Bleeding gums	2.2	2.9	14.0	-1.2	-1.0	-1.1	-0.1	-0.1	3.7
Diabetes diagnosed by doctor	2.2	3.6	14.8	0.2	0.3	0.4	2.5	0.3	3.9
Alcohol drinker status: Never	2.2	2.6	5.0	2.2	0.6	2.2	0.8	0.8	2.1
Heart attack/myocardial infarction (self-reported)	2.2	2.9	9.2	1.3	1.5	1.6	1.2	0.2	3.0
Bipolar Disorder (2011)	2.1	2.0	4.0	2.0	0.6	2.0	0.5	0.3	1.8
Medication: Ventolin 100micrograms inhaler	2.1	2.6	3.8	-1.6	-1.9	-1.6	-1.8	1.9	-0.1
Exposure to tobacco smoke outside home	2.1	2.8	6.0	-1.9	-1.1	-1.8	-2.4	1.3	-0.7
Chest pain or discomfort	2.1	3.1	4.5	2.0	2.1	2.1	1.5	0.8	1.6
Average weekly champagne plus white wine intake	2.1	2.8	7.1	-1.9	-2.7	-2.0	-1.0	-1.0	-0.3
Heart attack	2.0	2.5	8.4	1.1	1.5	1.4	1.1	0.3	2.9
Medication for cholesterol, blood pressure or diabetes	2.0	3.3	11.1	-1.0	-1.0	-1.1	-1.5	1.8	-3.3
Illness, injury, bereavement, stress in last 2 years	2.0	2.5	5.6	1.5	2.2	1.4	-0.2	0.4	-2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.4	6.6	0.2	1.0	0.3	2.0	-1.5	2.6
Past tobacco smoking	1.9	3.4	18.5	0.2	0.7	0.4	1.1	0.2	4.3
Commuting to job workplace: Car/motor vehicle	1.9	2.2	7.5	-1.2	-0.9	-1.3	-0.4	-1.3	-2.7
Basal cell carcinoma (self-reported)	1.9	2.2	4.9	-2.2	-0.8	-2.2	-1.2	-0.7	-1.0
Depression (self-reported)	1.8	2.1	4.2	2.0	1.6	2.0	1.1	-0.8	-0.3
Birth weight of first child	1.8	3.3	9.5	-1.1	0.2	-1.2	-2.6	-0.8	-3.1
Shortness of breath walking on level ground	1.8	2.2	6.0	0.9	1.3	1.0	1.9	0.3	2.4
Emphysema/chronic bronchitis	1.8	2.1	6.0	1.1	1.5	1.2	2.5	-0.3	1.2
Bipolar Disorder (2018)	1.7	2.7	5.5	2.3	1.7	2.3	1.3	-0.2	0.9
Age when periods started (menarche)	1.7	4.2	11.8	-2.0	-0.2	-2.3	1.0	-1.7	-3.4
Pulse wave reflection index	1.7	2.2	6.2	-0.7	0.1	-0.9	-2.5	-0.8	-2.2
Mean time to correctly identify matches	1.7	3.2	10.2	-1.1	-0.3	-1.2	-2.2	1.2	-3.2
Ever had prostate specific antigen (PSA) test	1.7	1.9	3.3	1.7	1.2	1.8	1.8	0.7	0.3
Alzheimer’s Disease (in father)	1.6	1.7	2.8	1.2	1.7	1.2	0.9	1.5	1.2
Diabetes (mother)	1.6	2.0	3.5	-1.6	-1.9	-1.8	-0.6	-0.0	-1.5
Allergy	1.6	3.6	8.1	2.9	0.3	2.9	0.9	1.7	1.3
Length of working week for main job	1.6	1.7	2.8	-1.7	0.0	-1.6	-0.6	-1.6	-1.4
Medication: Aspirin	1.6	2.1	3.8	1.8	1.9	1.9	0.8	0.6	1.1
Medication: Metformin	1.5	2.1	6.2	0.8	1.1	0.9	1.9	-0.1	2.5
Current tobacco smoking	1.5	2.4	8.8	0.9	1.7	0.8	-0.8	-0.9	-3.0
Waist circumference	1.5	5.4	8.6	2.9	2.9	2.9	2.4	-1.2	-0.1
Medication: Ramipril	1.5	1.9	3.0	-1.7	-1.3	-1.6	-0.9	-1.2	1.4
Hip circumference	1.5	6.5	9.4	2.9	3.1	2.9	2.5	-2.6	-0.2
Medication: Paracetamol	1.5	2.5	6.8	1.6	-0.6	1.6	2.6	-1.6	0.2
Medication: Seretide 50 evohaler	1.5	1.8	4.0	-1.3	-1.4	-1.1	-1.1	2.0	0.3
Heart disease (mother)	1.5	1.8	4.7	1.0	0.7	1.0	0.4	2.2	1.8
Ever taken oral contraceptive pill	1.5	1.7	3.1	1.4	0.8	1.4	1.8	-0.5	1.3
Illnesses of father: High blood pressure	1.5	1.9	3.6	-1.8	-1.7	-1.9	-1.2	0.3	0.2
Number of operations (self-reported)	1.5	2.2	4.2	-1.9	-1.9	-2.1	-0.5	-1.1	0.4
Myopia	1.5	2.1	8.9	0.9	0.1	1.1	-0.2	1.4	3.0
Smoking Status	1.4	3.2	16.0	1.2	0.8	1.0	-0.7	-0.3	-4.0
Average weekly spirits intake	1.4	1.7	5.5	-1.2	-1.4	-1.1	0.6	0.2	-2.4
Had menopause	1.4	1.8	3.2	1.4	1.8	1.5	0.9	1.2	-1.1
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.3	11.2	-0.4	-1.5	-0.3	0.2	0.5	3.4
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.7	3.3	1.7	1.0	1.8	0.4	1.2	1.2
Leg fat mass (right)	1.4	5.4	7.8	2.8	2.6	2.8	2.8	-1.6	-0.3
Number of self-reported non-cancer illnesses	1.4	2.5	9.2	-0.1	1.0	0.1	2.0	-0.7	3.0
Hearing aid user	1.4	1.6	3.5	1.9	0.8	1.9	-0.3	-1.0	-0.8
Mother’s age at death	1.4	1.8	4.0	-1.2	-0.8	-1.4	-0.6	-1.4	-2.0
Bipolar Disorder or Schizophrenia	1.3	3.2	7.7	2.7	0.4	2.8	0.9	-0.9	1.5
Chronotype (morning person)	1.3	2.9	7.8	-0.3	-2.7	-0.4	1.2	1.0	2.8
Supplements: Glucosamine	1.3	1.7	4.0	-0.9	-2.0	-1.1	-0.7	-0.5	-1.9
Body mass index (BMI)	1.3	5.4	7.7	2.7	2.8	2.7	2.5	-1.7	1.2
Father’s age at death	1.3	1.7	4.9	-0.5	-0.0	-0.7	-0.6	-2.1	-2.2
Ever highly irritable/argumentative for 2 days	1.3	1.6	2.7	-1.6	-1.6	-1.5	-0.6	0.5	1.2
Medication: Amlodipine	1.3	1.8	5.9	-0.0	1.4	0.1	0.1	-1.7	2.4
Leg fat percentage (right)	1.3	4.8	7.2	2.6	2.3	2.6	2.7	-1.6	-0.6
Loneliness, isolation	1.3	1.8	3.6	1.7	1.9	1.7	0.5	0.7	0.9
Smoking status: Current	1.3	2.1	8.2	0.8	1.4	0.7	-0.9	-0.8	-2.9
Leg fat percentage (left)	1.3	4.7	7.4	2.5	2.4	2.5	2.7	-1.5	-0.2
Alcohol drinker status: Previous	1.3	1.5	4.1	0.1	1.0	0.1	1.5	1.3	2.0
Leg fat mass (left)	1.3	5.2	7.4	2.7	2.6	2.7	2.7	-1.5	-0.1
Fasting Glucose	1.2	1.4	6.9	0.1	0.1	0.0	-0.9	0.8	-2.6
BMI	1.2	7.1	10.8	2.9	2.8	2.8	3.3	-1.4	2.5
Relative age of first facial hair	1.2	2.5	4.2	-1.8	-2.1	-1.9	-0.7	1.0	-1.6
Ever had hysterectomy (womb removed)	1.2	1.3	2.8	-1.0	0.3	-1.0	-0.7	-1.7	-1.6
Trunk fat mass	1.2	5.1	7.3	2.6	2.7	2.5	2.7	-1.7	-0.2
Had other major operations	1.2	1.4	4.2	-1.0	-2.1	-1.0	-1.5	-0.1	0.3
Mouth/teeth dental problems: Dentures	1.2	2.0	6.2	0.6	2.0	0.6	1.1	2.5	-0.4
Body fat percentage	1.2	4.9	8.2	2.6	2.5	2.5	2.9	-1.2	-0.1
Medication for pain relief, constipation, heartburn	1.2	2.0	3.8	-1.4	0.2	-1.5	-2.0	1.8	-0.7
Migraine (self-reported)	1.2	1.5	2.5	1.6	1.4	1.5	0.2	-1.0	-1.2
Whole body fat mass	1.2	4.9	7.0	2.6	2.5	2.6	2.6	-1.6	-0.2
Suffer from ‘nerves’	1.2	1.8	6.8	-1.1	-1.0	-1.1	-2.6	0.8	0.2
Smoking status: Previous	1.2	1.8	9.2	-0.2	-0.8	-0.3	-0.2	0.7	-3.0
Osteoporosis (self-reported)	1.2	1.5	5.9	-0.4	0.1	-0.5	1.3	2.4	-1.1
Commuting to job workplace: Public transport	1.2	1.4	6.0	0.6	1.3	0.6	-0.2	0.3	2.4
Medication: Paracetamol	1.2	1.9	5.6	0.7	-0.4	0.6	2.4	-2.2	0.2
Coronary Artery Disease (CAD)	1.1	1.4	5.3	0.1	1.1	0.4	1.0	0.7	2.3
Trunk fat percentage	1.1	4.4	7.5	2.3	2.6	2.3	2.7	-1.4	0.0
Townsend deprivation index at recruitment	1.1	1.5	3.2	-1.8	-1.0	-1.8	0.2	-1.4	0.2
Ever unenthusiastic/disinterested for a whole week	1.1	1.4	3.0	1.6	-0.9	1.7	-1.0	0.1	0.8
Arm fat percentage (right)	1.1	4.3	7.1	2.7	2.6	2.6	1.9	-1.0	0.3
Prospective memory result	1.1	1.4	4.6	1.0	0.1	1.0	2.2	1.1	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	4.0	0.7	-1.8	0.7	-0.8	2.0	-1.3
Blood clot in the leg (DVT)	1.1	1.5	5.1	-0.7	-0.9	-0.6	1.3	2.3	0.6
Medication: Ibuprofen	1.1	1.3	6.3	0.3	0.2	0.4	0.7	-2.5	0.8
Arm fat percentage (left)	1.1	4.3	6.7	2.5	2.6	2.5	2.1	-1.2	0.5
Pain experienced in last month	1.1	1.9	3.8	1.7	1.9	1.7	0.3	0.9	-0.8
Pack years of smoking	1.1	1.6	5.7	1.2	2.4	1.1	1.1	-0.5	0.3
Worry (Nagel 2018)	1.0	2.2	4.3	-1.2	-2.1	-1.0	-2.1	0.9	1.0
Triglycerides	1.0	1.7	6.6	-0.9	-0.9	-0.9	-2.6	-1.0	0.2
Type 2 Diabetes (T2D) (2018)	1.0	1.8	7.3	-0.6	-0.1	-0.5	1.7	-0.3	2.7
Neuroticism	1.0	2.5	6.4	-1.6	-2.5	-1.5	-1.8	0.6	0.5
Medication: Atenolol	1.0	1.3	2.5	1.0	0.5	1.0	1.5	-0.9	1.6
Alcohol usually taken with meals	1.0	1.7	7.9	0.7	-0.2	0.8	-0.9	-0.1	2.8
Hearing difficulty/problems with background noise	1.0	1.6	4.5	0.0	-1.0	-0.1	-1.9	-1.0	-2.1
Pain all over the body in last month	1.0	1.0	1.7	-1.2	-1.3	-1.3	0.2	-0.3	1.0
Number of live births	1.0	1.5	2.9	-1.6	-1.0	-1.7	-1.0	0.3	-1.1
Arm fat mass (right)	1.0	4.0	6.2	2.5	2.5	2.5	1.9	-1.4	0.2
Headache pain in last month	1.0	1.8	4.6	1.2	-1.0	1.2	1.2	-0.9	2.1
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	1.6	-1.2	-0.4	-1.3	1.3	0.9	-1.0
Commuting to job workplace: Walk	1.0	1.0	5.0	0.0	1.0	0.0	-0.3	2.2	0.3
Risk taking	1.0	1.4	2.4	1.2	-1.0	1.2	1.4	0.3	1.6
Systolic Blood Pressure	0.9	4.6	9.1	-3.0	-2.2	-2.9	-2.0	-0.4	0.9
Lung FEV1/FVC ratio	0.9	4.5	7.8	2.8	1.3	2.6	1.1	-2.0	-2.4
Average weekly fortified wine intake	0.9	1.0	4.0	-0.7	-0.7	-0.7	-0.8	0.3	-2.0
Relative age voice broke	0.9	1.3	4.1	-0.8	-2.0	-0.8	0.0	1.4	-0.8
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	1.9	1.3	1.0	1.4	0.8	0.0	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	3.1	0.9	-1.5	1.0	0.5	0.9	1.8
Medication: Omeprazole	0.9	1.1	2.7	0.6	0.4	0.7	0.5	-1.6	1.6
Arm fat mass (left)	0.9	3.6	5.6	2.3	2.4	2.3	1.7	-1.4	0.5
Pain type(s) experienced in last month: Hip pain	0.9	1.1	2.1	1.4	1.0	1.4	0.5	-0.5	-1.0
Medication: Lisinopril	0.9	1.1	2.0	-1.3	-0.5	-1.4	-1.3	-0.9	0.4
Unable to work because of sickness or disability	0.9	1.1	1.7	1.3	0.7	1.3	0.8	1.3	0.8
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	5.0	-0.5	-0.6	-0.5	1.1	2.2	0.4
Intelligence (Savage-Jansen 2018)	0.8	2.3	4.2	-1.8	0.3	-2.0	-2.0	-0.9	-1.3
Verbal and Numeric Reasoning (VNR)	0.8	1.8	7.0	-1.2	-0.2	-1.3	-2.7	-0.3	-0.8
Ovarian Cancer	0.8	1.1	3.1	-0.4	-1.6	-0.4	-1.7	-0.3	-0.6
Prostate Cancer	0.8	1.2	2.9	-1.2	-1.7	-1.0	-0.7	-0.2	1.1
Age at First Birth	0.8	1.2	2.8	0.2	0.7	0.3	1.0	1.7	1.6
LDL Cholesterol	0.8	1.3	4.0	-0.8	-0.5	-0.7	0.4	-1.5	2.0
Ever used hormone-replacement therapy (HRT)	0.8	1.1	2.3	-1.5	-0.0	-1.5	-0.1	0.5	-1.2
Supplements: Zinc	0.8	0.8	2.8	-0.5	-0.0	-0.6	-1.7	-0.9	-0.9
Neuroticism score	0.8	1.7	5.5	-0.5	-2.3	-0.4	-1.9	0.7	0.3
Weight	0.8	4.1	6.0	2.4	2.5	2.4	2.0	-1.6	0.3
Alcohol intake versus 10 years previously	0.8	1.2	5.1	0.9	2.3	1.0	0.5	-0.1	0.1
Happiness	0.8	1.0	2.2	1.1	-1.5	1.2	-0.9	0.3	0.0
Noisy workplace	0.8	1.0	4.3	0.5	0.2	0.4	2.1	0.1	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	5.4	0.4	-0.1	0.5	0.7	-2.3	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	3.3	0.1	-0.7	0.1	-1.8	1.1	-1.1
Health satisfaction	0.8	1.0	5.3	0.3	-0.1	0.5	-0.2	0.7	2.3
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	4.0	-0.2	-1.1	-0.2	-0.1	2.0	-0.4
Illnesses of father: Heart disease	0.8	1.1	5.0	0.5	-0.7	0.6	-0.2	-0.6	2.2
Back pain experienced in last month	0.8	1.1	3.1	-0.8	-0.3	-0.7	0.8	1.3	1.8
Medication: Bendroflumethiazide	0.8	1.3	3.2	-1.3	0.0	-1.3	-0.9	-1.8	0.0
Heart disease (siblings)	0.8	1.0	2.2	0.4	-1.3	0.5	1.5	0.7	1.0
Neuroticism (Nagel 2018)	0.7	1.5	5.8	-0.9	-2.4	-0.8	-1.3	0.1	0.4
Schizophrenia (2018)	0.7	1.5	2.9	1.7	-1.1	1.7	-0.4	-1.0	1.2
Major Depression (MDD)	0.7	0.8	2.1	1.4	0.4	1.5	0.7	0.4	0.4
Ulcerative Colitis	0.7	1.0	2.2	-0.9	0.3	-0.8	-1.3	-0.6	1.5
Medication: Co-codamol	0.7	0.8	2.0	1.4	0.2	1.3	0.9	0.5	-0.4
Maternal smoking around birth	0.7	1.0	3.6	-0.6	0.5	-0.7	0.1	-1.9	-1.0
High blood pressure (mother)	0.7	1.0	1.9	1.1	1.2	0.9	-0.6	-1.4	-0.3
Nervous feelings	0.7	1.2	3.5	-0.3	-1.9	-0.2	-1.3	1.2	0.8
Mouth/teeth dental problems	0.7	1.0	3.7	-0.1	-0.6	-0.0	-0.6	-1.2	-1.9
Lung cancer (father)	0.7	0.8	1.4	-0.9	-0.5	-1.0	-0.8	-0.7	-1.2
Exposure to tobacco smoke at home	0.7	0.8	3.2	-0.3	-0.3	-0.4	1.8	-0.3	-1.2
Glaucoma (self-reported)	0.7	0.8	2.1	-0.5	0.5	-0.7	1.4	-1.2	0.2
High blood pressure (siblings)	0.7	1.0	3.1	-0.5	-0.8	-0.7	-1.2	-0.4	-1.8
Medication: Blood pressure	0.7	1.3	5.9	-0.1	0.5	-0.1	0.4	-1.1	2.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.2	-0.9	-0.8	-0.9	-1.1	-0.5	-1.0
Family relationship satisfaction	0.7	0.8	2.4	-0.2	-1.6	-0.2	-1.2	1.0	-0.2
Leg pain on walking	0.7	0.9	3.8	-0.5	-0.9	-0.5	0.1	-0.5	2.0
Supplements: Vitamin C	0.7	0.8	3.2	0.8	-0.1	0.6	-0.7	0.1	-1.8
Qualifications: nursing, teaching	0.7	1.0	1.6	1.0	0.9	1.1	-0.5	1.1	1.3
Miserableness	0.7	1.2	5.2	0.2	-2.3	0.3	-1.1	-0.4	0.6
Age started oral contraceptive pill	0.7	0.9	1.9	0.1	1.0	0.2	1.3	1.4	0.9
Diastolic blood pressure, automated reading	0.7	2.2	3.6	-1.7	-0.9	-1.9	1.4	-1.7	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.8	0.4	0.0	0.4	0.6	-1.1	1.7
Alzheimer’s Disease (in mother)	0.6	0.8	2.1	0.9	1.5	0.9	0.8	-0.4	0.2
Irritable Bowel Disease (IBD)	0.6	1.5	3.6	-1.4	-0.2	-1.7	-0.5	-0.7	-1.9
Type 2 Diabetes (T2D) (2012)	0.6	0.7	3.8	-0.3	-2.0	-0.4	0.3	0.5	-0.3
Heel T-Score	0.6	4.5	9.9	3.0	1.1	3.1	2.3	-0.5	1.0
Hand grip strength (left)	0.6	1.5	6.9	0.6	1.2	0.6	-0.1	-0.3	-2.6
Pack years adult smoking proportion	0.6	0.9	3.1	0.7	1.8	0.7	0.7	-0.3	0.8
Impedance of leg (right)	0.6	3.0	9.4	-1.3	-2.0	-1.4	-0.9	0.2	-3.1
Impedance of leg (left)	0.6	3.0	7.6	-1.5	-2.1	-1.6	-0.8	0.7	-2.8
Qualifications: None of the above	0.6	1.2	3.2	-0.8	0.6	-0.9	1.8	-1.5	-0.3
Medication: Simvastatin	0.6	0.9	2.3	-1.0	0.2	-1.0	0.3	-0.8	1.5
Fluid intelligence score	0.6	1.2	4.2	-1.1	-0.5	-1.0	-2.1	-0.9	0.1
Worrier / anxious feelings	0.6	1.1	4.4	-0.5	-2.1	-0.4	-1.1	0.8	0.4
Comparative body size at age 10	0.6	1.8	3.8	1.9	0.1	1.9	0.2	1.7	-0.3
Eye problems/disorders: None of the above	0.6	0.8	2.0	-0.5	-1.1	-0.4	-1.4	0.8	0.6
Comparative height size at age 10	0.6	3.2	6.9	2.2	2.6	2.2	0.9	1.0	-0.9
Number of full sisters	0.6	0.7	4.1	-0.1	-0.1	-0.1	-0.0	0.1	2.0
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	2.8	-1.2	-1.7	-1.2	-1.3	0.3	-0.0
Eye problems/disorders: Cataract	0.6	0.7	1.5	1.0	0.4	1.0	1.2	0.4	-0.4
Medication for cholesterol	0.6	1.0	2.6	-0.7	-0.9	-0.6	-1.6	0.8	-1.0
Illnesses of father: None of the above (group 1)	0.6	0.8	1.6	0.8	1.3	0.9	0.8	-1.0	-0.2
Eye problems/disorders: Glaucoma	0.6	0.7	1.3	-0.5	0.9	-0.7	1.1	-1.1	-0.2
Impedance of whole body	0.6	3.2	4.1	-1.8	-1.9	-1.9	-1.4	1.5	-2.0
Alzheimer’s Disease (including proxy)	0.5	0.7	1.4	0.7	1.2	0.6	0.8	0.5	0.9
Mean Putamen Volume	0.5	0.5	0.8	0.9	0.3	0.8	-0.6	0.8	-0.8
HbA1C	0.5	0.5	1.8	-0.2	0.0	-0.2	0.2	-1.1	1.4
Neuroticism (2016)	0.5	0.6	1.9	-0.8	-1.4	-0.8	0.3	-0.8	-0.0
Blood Eosinophil Count	0.5	4.1	13.5	1.6	2.0	1.3	1.4	-1.1	-3.7
Cardiovascular Disease	0.5	1.6	6.1	-0.1	-0.3	-0.0	1.3	-1.4	2.5
Lung FVC	0.5	2.5	12.9	-0.5	0.6	-0.3	-0.2	1.2	3.6
Sensitivity / hurt feelings	0.5	0.9	2.4	-0.6	-0.7	-0.6	-1.2	-0.0	-1.5
Hearing difficulty/problems: Yes	0.5	0.7	2.5	0.8	-0.4	0.9	-1.6	-0.4	0.1
Leg fat-free mass (left)	0.5	2.7	4.2	2.0	2.0	2.1	1.2	-1.4	0.6
Qualifications: CSEs or equivalent	0.5	0.7	2.1	-1.0	-0.4	-0.9	-0.5	0.1	1.4
High blood pressure	0.5	1.3	3.9	-1.3	0.5	-1.3	-0.1	-2.0	0.6
Leg predicted mass (left)	0.5	2.8	4.4	2.0	2.0	2.1	1.3	-1.4	0.7
Illnesses of siblings	0.5	0.8	1.9	1.3	0.7	1.4	0.1	-0.2	0.7
Impedance of arm (right)	0.5	2.4	3.5	-1.3	-1.3	-1.3	-1.5	1.8	-1.9
Impedance of arm (left)	0.5	2.1	3.0	-1.7	-1.2	-1.7	-1.3	1.6	-1.1
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	3.2	0.6	0.4	0.6	-1.8	0.6	-0.1
Leg fat-free mass (right)	0.5	2.5	3.9	1.9	2.0	1.9	1.1	-1.1	1.2
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.1	-1.2	-1.0	-1.4	-0.1	-0.1	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.4	0.6	1.2	0.6	-1.2	0.2	0.5
Breast cancer (self-reported)	0.5	0.6	1.4	-0.8	-0.0	-0.8	0.9	-1.2	0.4
Medication: Gliclazide	0.5	0.6	2.2	-0.0	0.0	0.2	0.9	0.6	1.5
Leg predicted mass (right)	0.5	2.5	4.0	1.9	1.9	2.0	1.1	-1.1	1.1
Fractured/broken bones in last 5 years	0.5	0.6	1.7	-0.1	-0.7	-0.3	1.1	-1.3	-0.2
Ever depressed for a whole week	0.5	0.6	1.1	1.1	-0.3	1.0	0.7	-0.9	0.2
HDL Cholesterol	0.4	0.6	1.0	1.0	-0.9	1.0	0.9	-0.3	0.1
Primary Biliary Cirrhosis	0.4	0.5	2.6	-0.3	-0.4	-0.3	0.3	1.6	0.1
Blood Red Count	0.4	4.0	6.6	-2.2	-0.5	-2.2	-2.4	2.6	1.3
Diabetes (father)	0.4	0.5	2.0	0.3	0.5	0.3	0.8	0.3	1.4
Severe depression (siblings)	0.4	0.5	1.3	0.8	0.3	0.8	-0.3	1.1	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.5	-0.6	-1.2	-0.5	0.6	0.1	0.6
Stomach or abdominal pain in last month	0.4	0.5	1.7	0.3	-0.1	0.4	1.1	-0.0	1.3
Time employed in main current job	0.4	0.5	1.1	-0.6	0.6	-0.6	-0.4	-1.1	-0.7
Hair/balding pattern: Pattern 3	0.4	0.7	1.4	-0.7	1.2	-0.7	-0.7	1.0	-0.4
Qualifications: A levels/AS levels or equivalent	0.4	1.0	5.1	0.6	-0.1	0.5	-2.2	0.3	-0.4
Medication: Lansoprazole	0.4	0.5	2.1	-0.2	0.0	-0.1	1.4	0.2	0.9
Gout (self-reported)	0.4	0.5	1.1	0.4	0.9	0.2	1.1	-0.7	-0.6
Wheeze or whistling in the chest in last year	0.4	0.7	2.1	-0.3	-0.9	-0.3	-0.7	-0.6	-1.4
Number of children fathered	0.4	0.4	1.3	0.3	0.6	0.3	-1.1	0.4	-0.6
Qualifications: College or University degree	0.4	1.3	5.6	-0.6	-0.9	-0.6	-2.4	0.1	0.8
Had major operations	0.4	0.5	1.8	-0.4	-0.7	-0.5	0.0	0.1	1.4
Age at last live birth	0.4	0.6	1.2	-1.1	-0.9	-0.9	-0.3	0.5	0.6
Hypertension (Self-reported)	0.4	1.2	3.2	-1.4	0.1	-1.3	-0.2	-1.8	0.7
Mood swings	0.4	0.7	3.5	0.4	-1.9	0.4	0.4	-0.3	0.5
Friendships satisfaction	0.4	0.5	1.1	0.6	-0.0	0.6	-1.0	-0.4	0.9
Mineral and other dietary supplements	0.4	0.5	1.3	0.0	1.1	0.1	-0.8	0.7	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	4.5	-0.1	-0.0	0.2	-0.1	0.3	2.1
Whole body water mass	0.4	2.1	3.3	1.8	1.6	1.8	0.8	-1.7	-0.0
Basal metabolic rate	0.4	2.4	3.8	1.9	1.7	1.9	1.1	-1.7	0.1
Average weekly beer plus cider intake	0.4	0.5	2.3	-0.1	-0.1	-0.2	-0.7	0.4	-1.5
Irritability	0.4	0.7	1.8	-0.3	-1.4	-0.2	-0.8	-0.5	1.0
Arm predicted mass (left)	0.4	2.3	3.5	1.9	1.7	1.9	1.0	-1.7	-0.1
Depression (Nagel 2018)	0.3	0.5	1.1	1.1	-0.4	1.1	0.4	-0.3	0.4
Schizophrenia (2014)	0.3	0.7	1.7	1.3	-0.6	1.3	-0.5	0.2	0.4
Blood Platelet Count	0.3	3.0	4.3	-2.1	-1.3	-2.0	-2.1	-1.8	0.5
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.4	0.1	-0.6	0.2	-1.2	0.7	0.1
Medication for hormone replacement therapy	0.3	0.3	1.0	0.2	-0.6	0.2	-0.2	0.5	-1.0
Chronic bronchitis/emphysema (father)	0.3	0.3	1.4	-0.2	-0.3	-0.3	-0.5	-0.1	-1.2
Forced vital capacity (FVC)	0.3	1.3	3.7	-1.3	-0.3	-1.1	-0.6	0.9	1.9
Financial difficulties in last 2 years	0.3	0.4	1.5	-0.3	-0.1	-0.4	1.2	0.4	0.5
Trunk fat-free mass	0.3	1.8	4.0	1.5	1.2	1.5	0.4	-2.0	-0.8
Trunk predicted mass	0.3	1.7	3.6	1.5	1.2	1.5	0.4	-1.9	-0.8
Breastfed as a baby	0.3	0.3	0.8	0.1	0.8	0.1	0.1	0.6	-0.9
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.8	0.5	0.2	0.5	0.7	-0.9	0.5
Arm fat-free mass (right)	0.3	1.8	3.4	1.4	1.5	1.4	1.0	-1.8	-0.0
Mouth/teeth dental problems: Loose teeth	0.3	0.3	1.1	0.2	0.7	0.2	-0.4	-1.0	0.3
Arm predicted mass (right)	0.3	1.7	2.4	1.4	1.5	1.4	1.0	-1.6	-0.0
Pulse rate, automated reading	0.3	0.9	2.5	0.1	0.7	0.2	1.3	-1.6	0.6
Knee pain experienced in last month	0.3	0.5	1.8	0.3	0.3	0.2	0.2	-0.9	1.3
Illnesses of siblings: Diabetes	0.3	0.4	0.9	0.2	1.0	0.3	1.0	-0.2	0.5
Whole body fat-free mass	0.3	1.9	3.1	1.7	1.4	1.7	0.8	-1.8	-0.0
Average weekly red wine intake	0.3	0.4	1.9	0.4	-0.3	0.5	1.4	-0.0	0.4
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.9	0.3	-0.2	0.2	0.9	-0.6	-0.9
Medication: Blood pressure	0.3	0.6	1.6	-0.8	0.6	-0.8	0.1	-1.3	-0.1
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.2	0.2	0.3	0.2	1.1	-0.4	-0.9
High cholesterol (Self-reported)	0.3	0.5	1.8	0.0	-0.0	-0.0	0.5	-1.3	1.0
Arm fat-free mass (left)	0.3	1.6	2.7	1.6	1.5	1.6	0.9	-1.2	-0.0
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.6	0.5	-1.1	0.5	-0.6	1.2	-1.3
Schizophrenia vs Biploar Disorder	0.2	0.3	0.7	-0.3	-0.7	-0.3	-0.7	0.9	0.1
Ulcerative Colitis (UC)	0.2	0.3	1.2	-0.2	0.6	-0.1	-1.1	0.3	0.6
Waist Hip Ratio (WHR)	0.2	0.7	3.3	0.3	0.4	0.3	0.1	1.8	-0.7
Respiratory disease	0.2	0.4	1.4	-0.7	-0.2	-0.5	-0.2	-0.1	1.2
Tanning	0.2	2.4	9.9	1.2	0.8	1.0	-0.5	1.1	-3.1
Systolic blood pressure, automated reading	0.2	0.5	0.9	-0.8	0.5	-1.0	0.9	-0.6	-0.2
Vitamin and mineral supplements	0.2	0.3	1.0	-0.1	0.5	0.0	0.5	-0.2	1.0
Hand grip strength (right)	0.2	0.6	2.2	0.7	1.5	0.7	0.2	0.2	-0.6
Fed-up feelings	0.2	0.4	0.8	-0.9	-0.7	-0.8	-0.2	-0.5	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.8	0.7	0.3	0.7	-0.5	-0.2	-0.9
Multivitamins +/- minerals	0.2	0.3	0.7	0.6	-0.1	0.5	-0.7	0.4	-0.9
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.8	-0.4	-0.9	-0.4	-0.1	0.3	0.5
Hair/balding pattern: Pattern 2	0.2	0.2	0.5	-0.1	-0.2	-0.2	0.7	-0.6	-0.5
Falls in the last year	0.2	0.2	0.8	0.2	-0.7	0.2	0.9	0.1	0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	3.4	-0.7	-0.4	-0.6	-0.4	0.3	1.8
Pulse rate	0.2	0.4	2.1	0.3	1.4	0.2	0.3	-0.2	0.4
Asthma	0.2	0.3	0.6	-0.8	0.0	-0.6	-0.6	0.5	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	3.2	-0.5	-0.3	-0.4	-0.2	-0.0	1.8
Hair/balding pattern: Pattern 4	0.2	0.4	1.3	0.6	-0.2	0.6	-0.3	-0.4	1.1
Loud music exposure frequency	0.2	0.2	0.7	0.1	-0.3	0.2	0.4	0.4	0.8
Forced vital capacity (FVC), Best measure	0.2	0.8	3.5	-0.6	-0.0	-0.5	-0.6	0.6	1.9
Number of full brothers	0.2	0.2	0.5	-0.4	-0.1	-0.5	-0.3	0.7	-0.5
Age at first live birth	0.2	0.4	0.8	-0.6	-0.6	-0.4	0.1	0.8	0.9
Medication: Allopurinol	0.2	0.3	1.1	-0.4	-0.1	-0.5	1.1	-0.3	-0.3
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.7	-0.1	-0.1	-0.0	-0.5	0.6	-0.9
Ever had bowel cancer screening	0.2	0.2	0.8	-0.1	-0.9	-0.1	-0.3	0.2	0.7
Asthma (self-reported)	0.2	0.3	0.6	-0.7	0.1	-0.4	-0.6	0.5	0.8
Osteoarthritis (self-reported)	0.2	0.2	0.8	-0.1	0.5	-0.2	0.3	-0.9	-0.4
Guilty feelings	0.2	0.3	0.9	0.9	-0.3	0.9	0.4	0.2	-0.1
Financial situation satisfaction	0.2	0.2	0.9	-0.0	-0.1	0.1	0.0	0.6	0.9
Depressed Affect (Nagel 2018)	0.1	0.3	1.1	0.2	-1.0	0.3	-0.0	-0.1	0.8
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	0.1	-0.2	0.1	-0.6	0.5	0.4
Height	0.1	1.2	5.8	-0.8	-0.1	-0.7	0.2	-0.4	-2.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.6	0.4	0.0	0.5	-0.2	-0.8	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.3	-0.4	-0.1	-0.3	0.5	0.4	0.6
Standing height	0.1	0.9	4.5	-0.2	-0.2	-0.3	-0.6	-0.3	-2.1
Peak expiratory flow (PEF)	0.1	0.3	0.7	-0.0	-0.5	-0.0	0.0	0.8	-0.9
Neck or shoulder pain in last month	0.1	0.1	0.3	0.6	-0.1	0.5	-0.0	0.0	-0.0
Cholesterol lowering medication	0.1	0.2	0.6	-0.2	0.8	-0.2	0.5	0.1	-0.2
Hair Pigment	0.0	1.1	5.9	0.5	-0.1	0.4	0.5	-0.6	2.4
Sitting height	0.0	0.2	0.4	0.3	-0.3	0.4	-0.1	0.5	0.6

Hub : Genes

PTPN22

Models

Trait associations