Hub : Genes

SIVA1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1160 0.0380 3.4e-04 0.068 0.045 0.048 0.055 0.062 1.2e-08 3.4e-06 1.4e-06 2.5e-07 4.4e-08
2 GTEx Artery Aorta 0.1060 0.0410 5.8e-03 0.066 NA 0.060 NA 0.063 1.7e-04 NA 3.3e-04 NA 2.3e-04
3 GTEx Artery Tibial 0.1532 0.0412 4.4e-06 0.139 NA 0.151 NA 0.144 5.3e-11 NA 6.9e-12 NA 2.4e-11
4 GTEx Colon Sigmoid 0.2050 0.0710 1.8e-03 0.013 NA 0.006 NA -0.008 1.1e-01 NA 1.9e-01 NA 9.4e-01
5 GTEx Esophagus Mucosa 0.1090 0.0410 2.4e-03 0.090 NA 0.027 NA 0.003 1.3e-06 NA 6.2e-03 NA 1.9e-01
6 GTEx Esophagus Muscularis 0.1200 0.0440 1.9e-03 0.096 NA 0.074 NA 0.009 1.9e-06 NA 2.8e-05 NA 8.5e-02
7 GTEx Liver 0.2660 0.1050 8.3e-03 -0.002 NA 0.009 NA 0.000 3.8e-01 NA 1.7e-01 NA 3.2e-01
8 GTEx Skin Sun Exposed Lower leg 0.0830 0.0340 7.4e-03 0.031 NA 0.003 NA 0.003 1.2e-03 NA 1.7e-01 NA 1.7e-01
9 GTEx Testis 0.2810 0.0720 2.2e-04 0.239 NA 0.227 NA 0.274 5.5e-11 NA 1.9e-10 NA 1.4e-12
10 YFS Blood 0.0239 0.0092 9.3e-04 0.006 0.008 0.009 0.008 0.009 3.8e-03 1.2e-03 5.1e-04 6.5e-04 4.5e-04
11 TCGA Esophageal Carcinoma 0.4340 0.1540 3.9e-03 -0.006 -0.001 0.075 NA 0.011 5.3e-01 3.4e-01 2.1e-03 NA 1.4e-01
12 TCGA Ovarian Serous Cystadenocarcinoma 0.0680 0.0450 8.4e-03 0.012 0.006 0.006 NA 0.013 5.0e-02 1.1e-01 1.3e-01 NA 4.2e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bipolar Disorder (2018) 1.2 1.9 5.8 2.4 -2.0 -1.1 0.0 -1.2 -1.3 1.3 -1.1 2.4 0.4 0.0 0.0
Bipolar Disorder or Schizophrenia 1.0 2.4 6.7 0.0 -2.6 -1.5 0.0 -1.8 -1.2 1.2 -1.8 2.1 2.6 0.0 0.0
Depressed Affect (Nagel 2018) 0.3 0.7 3.5 0.4 0.6 -0.1 0.0 -0.0 0.4 -1.2 -0.0 0.1 -0.9 -1.1 -1.9
Depression (Nagel 2018) 0.7 1.0 2.7 -0.6 1.5 1.0 0.0 0.8 1.0 -1.2 0.8 -0.6 -1.6 -1.4 -0.5
Intelligence (Savage-Jansen 2018) 0.2 0.7 1.5 -1.2 0.7 0.2 0.0 0.1 -0.7 0.9 0.1 -1.1 -1.0 1.1 1.2
Neuroticism (Nagel 2018) 0.5 1.1 6.0 0.6 0.2 -0.4 0.0 -0.3 0.1 -1.5 -0.2 0.5 -0.3 -2.1 -2.5
Schizophrenia (2018) 0.6 1.2 7.1 0.0 -1.7 -0.9 0.0 -1.4 -0.5 0.4 -1.3 0.0 2.7 0.0 0.0
Schizophrenia vs Biploar Disorder 0.1 0.1 0.8 0.0 -0.0 -0.2 0.0 -0.1 0.3 -0.5 -0.1 0.0 0.9 0.0 0.0
Worry (Nagel 2018) 0.2 0.4 1.6 0.1 -0.2 -0.8 0.0 -0.7 -0.6 -0.3 -0.7 0.2 0.5 -1.3 -0.8
Alzheimer’s Disease (in mother) 0.2 0.2 0.7 0.7 -0.8 -0.4 0.0 -0.5 -0.3 0.1 -0.5 0.6 0.1 -0.2 -0.8
Alzheimer’s Disease (in father) 0.2 0.3 0.9 0.3 0.3 -0.2 0.0 -0.0 0.7 -0.7 -0.1 0.4 -0.8 0.2 -1.0
Alzheimer’s Disease (including proxy) 0.7 1.0 3.0 0.8 -0.8 -1.3 0.0 -1.1 -0.6 -1.2 -1.1 0.9 -0.4 -0.4 -1.7
Crohns Disease (2017) 0.3 0.7 2.9 -1.2 0.8 0.2 0.0 0.3 0.5 -1.7 0.3 -1.3 -1.1 -0.6 -0.5
Irritable Bowel Disease (IBD) 0.3 0.8 2.4 0.1 -0.8 -1.0 0.0 -0.9 -0.9 -1.5 -0.9 -0.3 -0.4 -0.5 -1.5
Ulcerative Colitis (UC) 1.2 2.2 4.6 1.0 -2.1 -2.1 0.0 -2.0 -2.1 -0.3 -2.0 0.5 0.8 -0.4 -1.7
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 1.5 2.8 4.6 -1.8 2.1 2.1 0.0 2.0 1.4 -1.3 2.0 -1.8 -1.9 0.3 1.4
Verbal and Numeric Reasoning (VNR) 0.5 1.1 4.1 0.4 -1.0 -1.2 0.0 -1.4 -2.0 0.5 -1.4 0.2 0.3 1.2 1.0
Breast Cancer 5.1 12.2 29.6 -1.9 4.8 5.4 0.0 5.4 4.3 1.3 5.4 -1.3 -2.4 0.6 2.1
Ovarian Cancer 1.1 1.4 3.4 -0.0 1.1 1.8 0.0 1.8 1.8 -1.7 1.8 0.0 -0.6 0.2 -0.1
Prostate Cancer 1.2 1.7 3.8 1.0 -1.1 -1.8 0.0 -1.9 -1.9 -0.6 -1.9 0.8 -0.2 0.8 -1.5
Age at First Birth 1.2 1.8 3.7 1.2 -1.8 -1.7 0.0 -1.9 -1.7 1.1 -1.9 0.9 1.2 0.0 0.0
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.4 0.5 4.8 -0.4 0.2 0.4 0.0 0.3 0.0 2.2 0.3 -0.3 -0.6 0.0 0.0
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.6 0.9 4.0 -1.9 1.1 0.5 0.0 0.6 0.5 -0.2 0.6 -2.0 -0.8 0.0 0.0
Mean Putamen Volume 1.1 1.2 3.6 -0.5 -0.8 -1.8 0.0 -1.8 -1.9 -0.1 -1.7 -0.7 -0.1 -0.5 0.5
Fasting Glucose 0.3 0.4 1.8 0.9 -1.0 -0.3 0.0 -0.4 -0.1 -0.8 -0.3 1.4 0.5 0.0 0.0
HbA1C 1.7 1.9 4.6 -1.6 1.6 1.7 0.0 1.7 2.1 -0.8 1.7 -1.7 -0.8 0.0 0.0
HDL Cholesterol 1.0 1.7 7.0 0.9 -1.7 -1.5 0.0 -1.3 -1.0 1.9 -1.3 0.2 2.6 0.0 0.0
LDL Cholesterol 0.3 0.5 1.5 0.7 -0.9 -0.9 0.0 -0.9 -1.2 -0.3 -0.9 0.7 0.1 0.0 0.0
Lupus 0.3 0.4 3.8 0.4 -0.1 0.3 0.0 0.4 0.2 0.4 0.4 0.7 -0.1 2.0 0.2
Neuroticism (2016) 0.9 1.4 5.9 -0.1 -0.9 -1.1 0.0 -1.4 -1.6 0.4 -1.4 -0.2 1.2 -2.4 -0.6
Primary Biliary Cirrhosis 1.9 2.7 6.0 2.4 -2.0 -1.5 0.0 -1.5 -0.6 1.2 -1.5 2.4 1.4 0.1 -2.4
Rheumatoid Arthritis 0.6 0.8 4.2 2.0 -0.9 -0.9 0.0 -1.1 -0.6 -1.1 -1.1 0.0 -0.7 0.0 0.0
Schizophrenia (2014) 0.4 0.9 4.3 0.0 -1.6 -1.0 0.0 -1.2 -0.3 0.3 -1.2 0.0 2.1 0.0 0.0
Triglycerides 0.7 1.1 2.5 -1.2 1.5 1.6 0.0 1.2 0.4 -1.0 1.2 -1.2 -1.0 0.0 0.0
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0
Ulcerative Colitis 1.2 1.7 6.0 0.0 -2.5 -1.6 0.0 -1.8 -2.0 -0.1 -1.8 0.0 1.3 0.0 0.0
Blood Eosinophil Count 0.2 1.2 3.7 -0.5 0.5 1.1 0.0 1.2 1.2 -1.2 1.2 -0.7 1.2 -1.3 1.9
Blood Platelet Count 0.2 2.7 9.1 -0.5 2.1 1.9 0.0 2.0 0.9 -3.0 2.0 -0.7 -2.3 0.2 -0.5
Blood Red Count 0.4 4.3 14.0 2.3 -3.3 -2.3 0.0 -2.4 -1.7 -0.2 -2.4 1.3 3.7 -0.3 -0.4
Blood White Count 1.0 7.3 19.3 -1.3 3.7 3.6 0.0 3.4 2.8 -1.5 3.4 -0.2 -4.4 1.8 1.6
Heel T-Score 0.2 1.8 15.1 1.0 -0.3 -0.4 0.0 -0.6 -0.9 0.7 -0.6 1.0 -1.3 3.9 -0.6
BMI 0.2 1.1 3.3 -0.5 1.0 1.7 0.0 1.4 0.8 -1.8 1.3 -0.1 -1.0 0.4 0.8
Height 0.1 1.2 3.5 1.0 -1.3 -0.4 0.0 -0.8 -1.7 1.9 -0.8 0.8 0.8 1.1 1.0
Waist Hip Ratio (WHR) 0.3 1.3 5.7 0.0 0.5 1.3 0.0 1.3 1.3 -2.4 1.3 0.5 -1.0 1.4 -0.1
Systolic Blood Pressure 0.1 0.4 2.6 -0.0 1.1 0.6 0.0 0.4 -0.3 -0.4 0.4 0.5 -0.1 -1.6 0.1
Smoking Status 0.6 1.4 5.5 0.4 -0.8 -1.0 0.0 -0.9 0.0 -2.3 -0.9 0.6 1.2 -2.0 -1.5
Allergy or Eczema 0.6 1.6 7.3 -1.1 -0.3 0.1 0.0 0.2 0.7 0.8 0.2 -1.9 2.5 -0.5 2.7
Cardiovascular Disease 0.6 2.1 5.4 -1.6 2.2 2.3 0.0 2.0 1.2 0.2 2.0 -1.1 -1.2 0.1 0.8
Hypothyroidism (self reported) 2.3 5.3 10.5 -1.8 2.8 3.0 0.0 3.2 2.8 -0.6 3.2 -1.9 -1.7 1.8 2.2
Respiratory disease 0.9 2.0 4.7 -1.5 1.6 1.4 0.0 1.7 2.2 -1.1 1.7 -1.5 -0.6 -0.3 1.7
Type 2 Diabetes (T2D) (2018) 1.4 2.6 6.3 -0.5 2.5 2.1 0.0 1.8 1.7 -1.7 1.8 0.1 -2.5 1.0 0.2
Lung FEV1/FVC ratio 1.3 6.3 15.2 -1.9 3.0 3.9 0.0 3.6 2.7 1.5 3.6 -1.3 -3.0 1.1 1.2
Lung FVC 2.2 11.0 19.6 -3.2 3.2 3.6 0.0 4.2 4.4 1.4 4.2 -3.3 -2.2 3.4 3.9
Neuroticism 0.7 1.6 5.9 0.6 -0.6 -1.1 0.0 -1.2 -0.9 -1.8 -1.2 0.3 1.2 -2.4 -1.7
Chronotype (morning person) 2.1 4.7 12.9 -1.9 2.3 2.5 0.0 2.7 2.1 1.8 2.6 -1.9 -0.6 1.7 3.6
Hair Pigment 0.1 3.3 8.0 -2.8 1.6 1.6 0.0 1.6 1.8 2.4 1.6 -2.8 -0.6 -0.9 1.9
Tanning 0.1 0.9 5.0 0.5 -1.3 -0.7 0.0 -0.8 -1.5 0.6 -0.7 0.3 2.2 0.3 0.4
Hand grip strength (left) 0.5 1.3 6.9 -0.0 -0.5 0.7 0.0 0.7 0.8 0.5 0.7 -0.9 1.9 1.1 2.6
Number of treatments/medications taken 0.3 0.6 1.8 -1.4 0.8 -0.9 0.0 -0.6 -0.4 -0.7 -0.6 -1.0 -1.0 -0.2 0.4
Average weekly spirits intake 1.4 1.7 5.1 -1.3 1.6 1.6 0.0 1.4 1.3 0.4 1.4 -1.5 -0.7 0.4 2.3
Sensitivity / hurt feelings 0.3 0.5 1.5 -0.1 0.6 1.2 0.0 1.1 0.7 0.1 1.1 -0.5 0.2 -0.7 0.0
Frequency of depressed mood in last 2 weeks 0.6 0.9 3.4 -0.8 1.1 1.0 0.0 0.5 0.4 -0.7 0.6 -0.8 -1.2 -1.8 -0.8
Hearing difficulty/problems: Yes 0.5 0.8 2.6 0.2 0.5 1.2 0.0 1.1 1.3 1.2 1.1 0.0 -0.0 -1.6 0.4
Relative age of first facial hair 0.8 1.7 5.1 0.6 0.6 1.6 0.0 1.8 2.2 0.1 1.8 0.3 0.5 0.7 2.3
Other serious medical condition/disability diagnosed by doctor 1.0 1.3 6.4 -1.9 0.9 -0.1 0.0 0.0 -0.5 1.2 -0.0 -1.4 -0.6 0.9 2.5
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.5 -0.7 -0.0 -0.7 0.0 -0.4 -0.3 -0.5 -0.4 -0.7 -0.5 0.6 0.4
Ever had hysterectomy (womb removed) 1.9 2.1 4.6 2.1 -1.4 -1.8 0.0 -1.8 -1.8 -0.6 -1.8 2.1 0.0 0.5 -1.2
Systolic blood pressure, automated reading 0.1 0.4 1.5 0.9 -0.0 -0.4 0.0 -0.5 -1.0 -0.8 -0.5 1.2 -0.1 -0.6 0.1
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 2.8 -0.5 1.1 1.2 0.0 1.0 1.4 -0.3 1.0 -0.2 -1.7 -0.4 -1.1
Angina 1.1 1.4 3.3 -1.6 1.8 0.9 0.0 1.0 1.6 1.1 1.0 -1.2 -1.7 -0.5 0.5
Medication for hormone replacement therapy 1.0 1.1 8.4 -0.7 -0.5 -0.5 0.0 -0.5 -0.6 -2.9 -0.5 -1.5 0.3 0.9 0.3
Vitamin and mineral supplements 0.7 1.0 3.3 1.7 -1.1 -0.2 0.0 -0.3 -0.2 0.1 -0.3 1.8 1.1 1.7 0.2
Supplements: Zinc 0.4 0.4 1.0 -0.8 -0.3 -0.9 0.0 -0.8 -0.5 -0.2 -0.8 -1.0 0.3 -0.9 -0.3
Medication: Co-codamol 0.8 0.9 3.3 0.0 1.8 0.6 0.0 0.8 1.3 -1.3 0.8 0.4 -1.5 -0.0 -0.5
Medication: Metformin 1.1 1.6 3.7 -1.3 1.9 1.5 0.0 1.4 1.5 0.0 1.4 -1.0 -1.9 0.7 0.8
Diabetes (father) 0.9 1.1 3.0 -1.7 1.3 0.6 0.0 0.4 -0.1 0.2 0.4 -1.6 -1.7 1.0 1.3
Diabetes (mother) 1.9 2.4 5.5 -1.8 2.3 1.7 0.0 1.3 1.2 -2.0 1.3 -1.5 -2.2 1.0 0.8
Severe depression (siblings) 0.8 0.9 4.2 1.5 -0.2 -0.1 0.0 0.1 0.1 -0.7 0.1 1.3 0.2 -2.1 -1.5
Pack years adult smoking proportion 0.2 0.3 1.0 0.5 -1.0 -0.6 0.0 -0.5 0.3 -0.1 -0.4 0.1 0.9 -0.7 0.8
Impedance of leg (right) 0.4 1.8 5.2 1.4 -1.5 -1.5 0.0 -1.3 -0.2 1.2 -1.3 1.1 1.7 -1.2 -2.3
Leg fat-free mass (left) 0.4 1.9 3.9 -1.0 0.9 2.0 0.0 1.7 0.9 -1.8 1.7 -1.2 -0.6 1.1 2.0
Trunk fat percentage 0.1 0.4 1.2 0.8 -0.4 -0.7 0.0 -0.7 -0.5 -1.0 -0.7 1.1 -0.1 0.5 -0.3
Hand grip strength (right) 1.2 3.4 19.8 -1.2 0.5 1.5 0.0 1.6 1.5 0.7 1.5 -1.9 1.1 2.2 4.4
Townsend deprivation index at recruitment 0.3 0.4 2.9 -0.1 0.2 0.8 0.0 0.6 0.6 0.4 0.6 -0.3 -0.4 1.7 -0.2
Current tobacco smoking 0.3 0.5 1.6 1.3 -0.7 -0.4 0.0 -0.4 -0.3 -1.0 -0.4 1.2 0.1 -0.4 -0.8
Average weekly fortified wine intake 0.2 0.3 1.4 0.4 0.1 0.3 0.0 -0.0 -0.3 -0.8 -0.0 0.4 -0.7 1.2 0.1
Maternal smoking around birth 0.3 0.4 1.6 -0.7 0.6 0.3 0.0 0.5 0.1 0.9 0.5 -1.0 0.4 -1.3 0.3
Fed-up feelings 0.6 1.0 4.8 -0.9 0.7 -0.2 0.0 -0.3 -0.1 -2.2 -0.3 -1.2 -1.5 -1.2 -1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 3.3 -0.7 1.3 1.2 0.0 0.9 0.5 -1.1 0.9 -0.7 -1.8 0.4 0.8
Relative age voice broke 0.5 0.8 3.8 0.6 -0.2 0.9 0.0 0.8 0.7 2.0 0.8 0.3 0.4 0.9 1.5
Taking other prescription medications 0.1 0.2 0.6 -0.5 0.7 -0.4 0.0 -0.1 -0.1 -0.4 -0.1 -0.1 -0.8 0.5 0.3
Age when periods started (menarche) 0.4 0.9 3.7 1.0 -1.3 -0.6 0.0 -0.7 -0.6 -1.0 -0.7 0.7 1.9 -0.8 -0.4
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.6 0.6 0.6 0.4 0.0 0.5 1.2 0.0 0.6 1.1 -1.3 0.4 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 1.1 2.4 6.9 0.1 1.7 2.0 0.0 1.8 1.6 1.9 1.8 0.0 -1.6 2.6 0.6
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.9 0.2 -0.3 0.2 0.0 0.3 0.5 0.9 0.3 -0.2 0.6 0.8 0.3
Qualifications: CSEs or equivalent 0.7 1.0 3.2 -1.1 1.1 1.8 0.0 1.1 0.8 -0.5 1.1 -1.0 -0.4 -0.6 0.9
Serious illness, injury or assault to yourself 0.7 0.8 2.3 -1.3 0.9 -0.8 0.0 -0.7 -0.4 0.6 -0.7 -0.9 -1.5 -1.4 -0.0
High blood pressure 0.5 1.4 4.3 -1.2 2.1 1.6 0.0 1.4 0.9 -0.5 1.4 -0.6 -1.3 -1.3 0.0
Hayfever, allergic rhinitis or eczema 0.6 1.2 6.7 -0.7 -0.7 0.0 0.0 0.1 0.4 1.6 0.1 -1.5 2.6 -0.1 1.4
Multivitamins +/- minerals 0.4 0.5 1.8 -1.0 0.9 -0.0 0.0 0.0 -0.0 -0.6 0.1 -0.9 -1.2 -1.3 -0.6
Stomach or abdominal pain in last month 0.4 0.4 2.1 -0.3 0.7 0.4 0.0 0.5 0.2 -1.5 0.5 -0.4 -1.1 -0.2 -0.7
Supplements: Glucosamine 0.5 0.6 2.9 -1.2 -0.4 0.1 0.0 -0.0 0.2 0.9 -0.0 -1.7 0.5 -0.2 1.2
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 2.2 1.1 -1.1 -0.4 0.0 -0.6 0.0 -1.0 -0.6 1.5 0.6 -0.1 -0.7
Medication: Atenolol 0.6 0.8 4.0 1.3 -0.5 -0.7 0.0 -1.0 -0.3 -0.6 -1.0 2.0 -0.4 -0.3 -0.9
Medication: Levothyroxine sodium 2.7 4.6 7.6 -2.0 2.8 2.2 0.0 2.6 2.4 -0.0 2.6 -2.2 -2.3 1.9 2.4
Sitting height 0.1 0.9 3.2 -0.2 -0.5 1.1 0.0 1.0 0.8 0.7 1.1 -0.7 0.8 1.2 1.8
Chronic bronchitis/emphysema (father) 0.3 0.4 1.4 -0.0 -0.5 -1.2 0.0 -0.8 -0.7 -0.7 -0.8 0.3 0.6 -0.3 -0.2
High blood pressure (mother) 0.9 1.3 2.0 -1.2 1.4 1.3 0.0 1.4 0.8 -0.6 1.4 -1.0 -1.2 1.4 1.0
Body mass index (BMI) 0.1 0.4 1.4 -0.4 0.9 0.8 0.0 0.6 0.3 -1.1 0.6 0.0 -1.2 0.4 0.2
Impedance of leg (left) 0.5 2.3 4.0 1.3 -1.8 -1.9 0.0 -1.7 -0.5 1.7 -1.7 1.0 1.9 -1.2 -2.0
Leg predicted mass (left) 0.4 1.9 3.9 -1.0 0.9 2.0 0.0 1.7 1.0 -1.7 1.7 -1.2 -0.7 1.2 2.0
Trunk fat mass 0.1 0.3 1.2 0.5 -0.4 -0.3 0.0 -0.4 -0.4 -1.1 -0.4 0.7 -0.1 0.8 0.1
Waist circumference 0.1 0.5 4.0 0.0 0.1 0.4 0.0 0.3 0.1 -2.0 0.3 0.4 -0.6 0.8 0.1
Number of incorrect matches in round 0.5 0.8 8.6 -0.0 -0.5 0.0 0.0 0.0 0.0 2.9 -0.0 0.1 0.4 0.8 0.4
Past tobacco smoking 0.9 1.7 3.8 0.2 1.3 2.0 0.0 1.8 0.9 1.4 1.8 0.2 -1.7 1.3 1.0
Alcohol usually taken with meals 0.8 1.2 4.1 -1.6 1.1 1.1 0.0 0.9 1.2 0.6 0.9 -1.5 -2.0 0.2 0.1
Nervous feelings 0.8 1.6 3.7 -0.8 1.9 1.4 0.0 1.7 1.8 0.9 1.6 -0.7 -1.6 0.0 0.0
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.5 3.8 -0.6 1.9 1.3 0.0 1.2 0.9 -0.8 1.2 -0.5 -1.7 -1.9 -1.0
Hearing difficulty/problems with background noise 0.4 0.6 2.4 1.2 -0.6 -0.4 0.0 -0.6 -0.7 0.4 -0.6 1.0 0.7 -1.6 -0.6
Hair/balding pattern: Pattern 2 0.6 0.7 4.1 -0.5 1.0 0.0 0.0 0.0 0.5 0.1 0.0 0.1 -2.0 -0.9 -1.5
Had menopause 0.5 0.7 1.7 0.6 -0.9 -1.3 0.0 -1.1 -0.9 -1.2 -1.1 0.4 0.7 0.1 0.2
Had other major operations 0.2 0.3 0.7 -0.4 -0.3 -0.8 0.0 -0.7 -0.6 0.4 -0.6 -0.8 0.0 0.5 0.6
Forced vital capacity (FVC) 1.4 5.5 11.1 -1.9 1.9 3.2 0.0 3.3 3.2 -0.0 3.3 -2.4 -1.1 2.0 2.3
Heel bone mineral density (BMD) T-score, automated (right) 1.7 3.9 12.6 0.2 2.1 2.1 0.0 2.1 1.9 2.2 2.0 0.6 -2.8 3.5 -0.3
Ever unenthusiastic/disinterested for a whole week 1.2 1.4 3.9 -0.7 1.6 2.0 0.0 1.6 1.0 -1.6 1.7 -0.7 -0.9 0.1 0.5
Qualifications: None of the above 0.9 2.0 6.1 2.4 -0.7 -0.7 0.0 -0.6 -0.7 -0.9 -0.6 2.5 0.3 -1.9 -2.3
Financial difficulties in last 2 years 2.5 3.3 6.6 -1.7 2.3 2.6 0.0 2.5 2.4 0.3 2.5 -1.2 -1.9 0.7 1.1
Mouth/teeth dental problems 0.1 0.2 0.8 -0.2 0.3 0.7 0.0 0.2 0.0 -0.9 0.2 0.0 -0.5 0.3 -0.5
Heart attack 1.0 1.3 4.5 -2.0 1.6 0.1 0.0 0.4 0.7 0.2 0.4 -1.6 -2.1 -1.1 0.3
Allergy 0.2 0.5 2.4 0.4 0.1 -0.3 0.0 -0.4 -0.7 0.1 -0.5 0.9 -1.6 0.3 -1.1
Pain all over the body in last month 1.3 1.4 4.1 -0.6 1.6 1.2 0.0 1.1 1.5 -0.6 1.1 0.0 -2.0 1.3 1.3
Diabetes (self-reported) 0.4 0.6 2.1 -0.5 1.3 0.8 0.0 0.6 1.0 -1.1 0.6 -0.3 -1.5 -0.2 -0.3
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 2.4 0.8 -0.5 -0.2 0.0 -0.1 -0.4 0.3 -0.1 0.3 1.1 -1.6 -1.2
Medication: Ramipril 0.2 0.3 1.3 -0.3 0.9 0.1 0.0 -0.0 -0.7 0.5 -0.0 -0.2 -1.2 -0.4 0.3
Medication: Simvastatin 0.9 1.3 5.1 -2.3 0.1 -0.4 0.0 -0.6 -0.4 0.3 -0.6 -2.2 0.1 0.0 2.1
Fluid intelligence score 0.1 0.2 0.5 -0.5 0.6 -0.0 0.0 0.0 -0.7 -0.1 0.0 -0.5 -0.4 0.7 0.7
Illnesses of siblings 0.3 0.4 3.4 0.1 -0.6 0.2 0.0 0.2 0.2 -0.8 0.2 -0.1 1.8 0.1 -0.1
Neuroticism score 0.3 0.6 4.1 -0.1 0.2 -0.3 0.0 -0.4 -0.0 -1.2 -0.4 -0.3 0.3 -2.0 -1.2
Weight 0.1 0.3 1.1 -0.3 0.3 0.9 0.0 0.7 0.2 -1.1 0.7 -0.2 -0.4 0.6 0.7
Impedance of arm (right) 0.4 2.0 3.8 1.6 -1.9 -1.9 0.0 -1.7 -1.4 0.3 -1.8 1.5 1.9 -0.0 -0.8
Arm fat percentage (right) 0.1 0.3 1.1 0.3 0.0 -0.3 0.0 -0.4 -0.5 -1.1 -0.4 0.8 -0.6 0.5 -0.1
Trunk fat-free mass 0.2 1.0 2.8 -0.9 0.3 1.6 0.0 1.3 0.5 -0.5 1.3 -1.1 -0.1 0.8 1.7
Hip circumference 0.1 0.3 1.5 1.2 -0.2 0.4 0.0 0.3 0.0 -0.5 0.3 1.2 0.1 0.1 -0.5
Time employed in main current job 1.8 2.1 5.4 2.2 -1.2 -1.5 0.0 -1.8 -1.8 -0.2 -1.7 2.3 0.3 0.4 -0.9
Alcohol intake versus 10 years previously 0.3 0.5 2.0 -0.2 0.1 -0.4 0.0 -0.3 -0.0 -0.9 -0.3 -0.7 -1.4 0.5 -1.4
Father’s age at death 0.5 0.7 4.0 -1.1 -0.4 -0.4 0.0 -0.5 -0.6 -0.7 -0.5 -1.0 0.1 0.9 2.0
Worrier / anxious feelings 0.2 0.3 1.1 0.4 -0.1 -0.4 0.0 -0.5 -0.5 -1.1 -0.5 0.4 -0.4 0.0 -1.0
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.3 5.6 -0.8 1.8 0.7 0.0 0.6 0.4 -1.1 0.6 -0.1 -2.4 -1.4 -1.1
Falls in the last year 1.4 1.9 4.3 0.2 1.9 2.1 0.0 2.1 1.4 -0.2 2.0 0.7 -1.8 0.7 0.7
Hair/balding pattern: Pattern 3 0.2 0.2 1.7 -0.1 -0.1 -0.1 0.0 0.1 0.2 1.3 0.1 -0.1 0.6 0.5 0.5
Number of live births 0.3 0.4 2.7 0.2 -0.4 -0.1 0.0 -0.2 0.1 -1.6 -0.2 0.0 -0.1 -0.9 -0.8
Forced expiratory volume in 1-second (FEV1) 3.1 10.5 22.0 -2.6 3.1 4.6 0.0 4.7 4.4 0.5 4.7 -3.0 -1.9 2.0 2.8
Pulse rate 0.6 1.0 5.4 1.1 -0.7 -0.6 0.0 -0.5 0.0 -2.3 -0.5 1.3 -0.2 1.0 -1.1
Happiness 0.2 0.3 1.9 -0.2 0.0 0.1 0.0 -0.1 0.0 -1.4 -0.1 -0.5 -0.1 0.5 0.8
Noisy workplace 0.5 0.6 1.3 -0.8 1.1 1.0 0.0 1.1 0.9 -0.5 1.1 -0.7 -0.7 -0.1 0.6
Qualifications: A levels/AS levels or equivalent 0.5 1.2 3.2 -1.2 0.4 1.0 0.0 0.9 0.5 1.5 0.8 -1.1 -0.1 1.7 1.8
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.5 4.9 0.5 0.1 0.3 0.0 0.3 0.4 -2.2 0.3 0.3 -0.1 -0.8 0.1
Mouth/teeth dental problems: Dentures 0.9 1.5 4.5 1.2 -1.3 -2.1 0.0 -1.6 -1.4 0.6 -1.6 0.8 1.3 -0.5 -0.8
Asthma 1.2 2.4 5.3 -1.7 1.9 1.4 0.0 1.9 2.3 -0.8 1.9 -1.5 -1.5 0.5 1.8
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.7 1.8 0.1 -0.7 -0.7 0.0 -0.8 -1.2 1.3 -0.7 0.3 1.1 -0.5 1.0
Medication: Cholesterol lowering 2.1 3.2 11.8 -3.4 2.1 0.8 0.0 0.9 0.9 1.2 0.9 -3.1 -1.9 0.4 2.0
Depression (self-reported) 0.4 0.5 1.0 -0.8 0.8 0.9 0.0 1.0 0.4 0.6 1.0 -0.7 -0.6 0.1 0.0
Medication: Lansoprazole 0.2 0.3 0.7 -0.5 0.4 -0.5 0.0 -0.5 -0.8 -0.4 -0.5 -0.6 -0.3 -0.8 0.4
Prospective memory result 0.1 0.1 0.4 -0.4 -0.0 0.2 0.0 0.2 0.1 0.6 0.1 -0.1 0.1 0.4 0.6
Lung cancer (father) 2.8 3.3 7.9 1.8 -1.6 -2.2 0.0 -2.1 -1.4 -1.4 -2.1 1.8 0.8 -2.0 -2.8
Illnesses of mother 0.3 0.4 1.9 0.5 -0.5 0.3 0.0 0.3 0.6 0.2 0.3 0.6 1.4 0.8 0.8
Forced expiratory volume in 1-second (FEV1), Best measure 3.9 12.4 25.8 -2.6 3.9 5.0 0.0 5.1 4.6 0.5 5.1 -2.7 -3.3 2.2 2.5
Pulse wave Arterial Stiffness index 1.3 1.5 3.2 0.8 -0.9 -1.8 0.0 -1.7 -1.2 -0.7 -1.7 1.2 -0.0 -1.5 -1.2
Impedance of arm (left) 0.4 1.9 3.7 1.6 -1.8 -1.9 0.0 -1.7 -1.2 -0.1 -1.7 1.5 1.8 0.1 -0.9
Arm fat mass (right) 0.1 0.2 1.1 -0.2 0.3 0.2 0.0 0.1 -0.1 -1.1 0.1 0.2 -0.9 0.8 0.2
Trunk predicted mass 0.2 1.1 2.8 -1.0 0.4 1.6 0.0 1.4 0.5 -0.5 1.4 -1.2 -0.2 0.8 1.7
Standing height 0.1 0.7 2.7 0.2 -1.4 0.2 0.0 0.2 -0.2 0.4 0.2 -0.5 1.6 1.0 1.5
Length of working week for main job 0.3 0.3 0.7 0.6 0.5 0.7 0.0 0.8 0.8 -0.3 0.8 0.5 0.0 0.5 -0.4
Exposure to tobacco smoke at home 0.6 0.7 4.5 1.1 -0.9 -0.5 0.0 -0.6 -0.3 -0.0 -0.6 0.6 2.1 -0.3 -0.2
Breastfed as a baby 0.3 0.3 1.1 0.9 -0.0 -0.2 0.0 -0.2 0.3 1.0 -0.2 0.8 -0.2 -0.4 -1.1
Tense / ‘highly strung’ 0.7 1.2 4.1 -1.8 -0.1 -0.7 0.0 -0.5 -0.8 1.4 -0.5 -2.0 0.7 -1.7 -0.0
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.5 3.1 -1.1 1.3 1.8 0.0 1.5 0.2 -1.8 1.5 -1.2 -0.2 -0.6 1.5
Hair/balding pattern: Pattern 4 0.2 0.4 2.2 -0.2 -0.2 0.2 0.0 -0.0 -1.1 0.8 -0.0 -0.3 1.5 -0.3 0.5
Birth weight of first child 1.0 1.8 4.8 -1.3 0.7 1.3 0.0 1.4 1.0 1.8 1.4 -1.6 0.2 2.2 1.3
Peak expiratory flow (PEF) 3.1 7.1 15.9 -2.9 2.0 3.2 0.0 3.4 3.1 0.4 3.4 -3.4 -0.5 1.4 4.0
Pulse wave reflection index 0.1 0.2 0.4 0.1 -0.1 -0.4 0.0 -0.6 -0.6 0.3 -0.6 0.1 0.1 -0.6 0.6
Ever highly irritable/argumentative for 2 days 0.7 0.9 1.7 -0.2 1.3 1.3 0.0 1.2 0.1 -1.3 1.2 -0.2 -0.7 -1.0 -1.0
Loud music exposure frequency 0.6 0.7 3.3 -1.1 -0.2 -0.3 0.0 -0.2 -0.6 0.1 -0.1 -1.5 1.8 -1.0 0.5
Qualifications: O levels/GCSEs or equivalent 0.8 1.3 5.6 -1.7 0.6 0.4 0.0 0.2 -0.1 0.1 0.2 -1.5 -1.1 2.4 1.6
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.1 0.4 0.1 0.7 0.0 1.0 1.0 -0.2 1.0 0.3 0.5 -0.4 0.3
Blood clot in the leg (DVT) 0.6 0.7 4.6 0.4 1.0 0.7 0.0 0.8 0.2 -2.1 0.8 0.4 -0.9 -0.6 -0.0
Medication: Paracetamol 0.3 0.5 2.7 -0.2 0.5 -0.2 0.0 -0.4 -0.3 -1.6 -0.4 -0.1 -1.3 -0.5 -0.7
Headache pain in last month 0.7 1.1 2.1 1.5 -0.7 -0.9 0.0 -1.2 -1.4 -1.0 -1.2 1.2 -0.9 1.0 -1.1
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 1.7 1.3 -1.0 -0.4 0.0 -0.4 -0.1 -0.4 -0.5 0.9 0.7 0.6 -1.2
Glaucoma (self-reported) 0.2 0.3 1.4 0.4 -0.2 -0.3 0.0 -0.3 -0.3 0.9 -0.3 0.4 0.1 1.2 0.2
Gout (self-reported) 0.7 0.9 5.9 0.2 -0.8 -0.2 0.0 -0.3 -0.6 -1.4 -0.3 0.0 0.9 2.4 1.0
Hypothyroidism/myxoedema (self-reported) 2.8 5.5 9.6 -2.1 2.9 2.7 0.0 3.1 2.7 0.0 3.1 -2.2 -2.2 2.1 2.3
Medication: Amlodipine 1.5 2.0 5.6 -1.8 1.9 1.2 0.0 1.2 0.6 2.4 1.2 -1.2 -2.3 0.5 0.9
Medication: Ventolin 100micrograms inhaler 0.5 0.7 1.3 0.7 -1.0 -1.1 0.0 -1.1 -0.5 -0.5 -1.1 0.7 0.9 -0.9 -0.2
Birth weight 0.7 1.4 5.2 -1.2 -0.2 0.6 0.0 0.7 1.2 1.4 0.7 -1.4 1.3 1.4 2.3
Chronic bronchitis/emphysema (mother) 0.4 0.4 2.8 0.3 -0.0 -0.4 0.0 -0.4 -0.0 0.4 -0.5 0.7 -0.0 -1.7 -1.0
High blood pressure (siblings) 0.6 0.9 2.0 0.8 -0.6 -1.2 0.0 -1.4 -1.4 1.0 -1.4 0.8 -0.8 0.5 -0.2
Forced vital capacity (FVC), Best measure 1.6 5.8 12.5 -1.6 2.5 3.3 0.0 3.5 3.1 0.0 3.5 -1.9 -2.2 2.0 1.6
Body fat percentage 0.1 0.4 1.0 0.6 -0.4 -0.7 0.0 -0.8 -0.5 -1.0 -0.8 0.9 -0.2 0.4 -0.5
Leg fat percentage (right) 0.2 0.7 3.3 0.9 -0.3 -0.6 0.0 -0.6 -0.2 -1.2 -0.6 1.2 -0.4 -0.2 -1.8
Arm fat-free mass (right) 0.3 1.3 3.2 -1.2 0.8 1.8 0.0 1.5 1.0 -0.6 1.5 -1.5 -0.6 0.6 1.4
Exposure to tobacco smoke outside home 0.6 0.8 3.2 0.5 0.3 1.1 0.0 0.8 0.2 -1.8 0.8 0.5 0.7 0.9 1.3
Comparative body size at age 10 1.4 3.9 9.8 -2.6 2.4 1.6 0.0 1.8 2.5 -0.6 1.8 -2.3 -1.4 1.1 3.1
Number of full brothers 1.4 1.8 3.9 -1.7 1.2 1.9 0.0 1.5 1.3 0.5 1.5 -1.7 0.3 0.0 2.0
Worry too long after embarrassment 0.9 1.5 8.0 1.3 -0.6 -0.8 0.0 -0.8 -0.4 -0.9 -0.8 1.4 0.7 -1.7 -2.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.1 4.5 1.7 0.3 0.5 0.0 0.2 -0.5 -1.1 0.2 2.1 -0.6 -0.6 -1.8
Wheeze or whistling in the chest in last year 0.3 0.5 1.7 -0.5 0.1 -1.3 0.0 -0.9 -0.6 -0.4 -0.9 -0.7 -0.4 -1.2 -0.1
Number of children fathered 0.7 0.7 1.6 -0.4 -1.1 -1.3 0.0 -1.3 -0.9 -0.7 -1.2 -0.4 0.8 -0.5 0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.4 0.2 0.5 1.1 0.0 1.0 0.6 0.4 1.0 0.3 -0.5 1.2 -0.1
Age at first live birth 0.6 1.0 5.2 -2.2 0.6 0.6 0.0 0.6 0.3 -0.2 0.6 -2.3 -0.1 -0.0 0.7
Pulse wave peak to peak time 1.5 1.8 3.7 -1.1 1.0 1.9 0.0 1.9 1.3 0.8 1.9 -1.5 0.1 1.6 1.4
Health satisfaction 1.1 1.4 3.8 1.6 -0.7 -1.0 0.0 -1.1 -0.9 -1.9 -1.0 1.3 -0.1 -1.3 -1.7
Shortness of breath walking on level ground 0.1 0.2 0.8 0.0 0.4 -0.2 0.0 -0.2 0.2 0.1 -0.1 -0.0 -0.7 -0.9 -0.4
Qualifications: College or University degree 0.2 0.5 2.7 -0.5 -0.6 0.2 0.0 0.3 0.3 0.3 0.3 -1.1 1.2 0.3 1.6
Eye problems/disorders: None of the above 0.5 0.5 3.1 -1.0 0.3 0.2 0.0 0.2 0.2 -1.1 0.1 -0.8 0.2 -1.8 0.1
Mouth/teeth dental problems: Loose teeth 0.3 0.3 2.1 -0.1 0.6 -0.3 0.0 -0.1 -0.4 -0.7 -0.1 -0.1 -1.5 -0.5 -0.7
Emphysema/chronic bronchitis 0.6 0.7 7.3 -0.2 0.3 0.0 0.0 0.2 0.1 0.1 0.2 -0.5 0.2 -2.7 -0.5
Medication for pain relief, constipation, heartburn 0.2 0.3 1.0 0.4 -0.4 0.6 0.0 0.6 0.6 0.4 0.6 0.2 1.0 -0.2 0.1
Neck or shoulder pain in last month 0.5 0.8 4.0 1.1 0.2 0.0 0.0 0.1 0.6 -0.9 0.1 1.2 -0.6 -1.0 -2.0
Medication: Blood pressure 0.2 0.3 2.8 -0.3 0.4 -0.2 0.0 0.0 -0.4 -0.7 0.0 0.2 -0.3 -1.7 -0.4
Angina (self-reported) 0.9 1.2 2.8 -1.4 1.7 0.8 0.0 1.0 1.5 1.0 0.9 -1.1 -1.5 -0.3 0.5
Migraine (self-reported) 0.6 0.7 1.8 1.1 0.4 0.3 0.0 0.4 0.5 -1.3 0.4 1.3 -1.3 0.4 -1.1
Medication: Ibuprofen 0.3 0.4 1.4 -0.1 -0.1 -0.7 0.0 -0.7 -1.2 1.1 -0.6 0.2 -0.0 -0.4 0.7
Medication: Allopurinol 0.4 0.5 3.0 1.0 -0.5 0.1 0.0 -0.1 -0.3 -0.6 -0.1 0.9 0.5 1.7 0.1
Medication: Omeprazole 0.6 0.7 2.3 0.2 -0.4 -0.9 0.0 -0.8 -1.0 -0.6 -0.8 0.0 0.8 -1.3 -1.5
Medication: Seretide 50 evohaler 1.0 1.2 2.8 -0.5 1.5 1.3 0.0 1.5 1.5 -0.2 1.5 -0.1 -1.7 -0.4 -0.1
Mean time to correctly identify matches 0.4 0.8 2.5 -0.6 1.0 0.9 0.0 0.8 0.1 -0.7 0.8 -0.6 -1.6 1.1 1.0
Heart disease (mother) 0.9 1.1 5.2 -1.6 -0.0 -0.9 0.0 -1.0 -1.2 -0.6 -1.0 -2.3 0.3 -1.0 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 3.2 0.3 -1.3 -1.3 0.0 -1.4 -0.9 -0.8 -1.4 -0.3 1.8 -1.8 -0.4
Whole body fat mass 0.1 0.2 1.3 0.3 -0.2 -0.0 0.0 -0.1 -0.2 -1.2 -0.2 0.5 -0.3 0.9 0.1
Leg fat mass (right) 0.1 0.2 1.5 0.2 -0.4 -0.3 0.0 -0.4 -0.2 -1.2 -0.4 0.3 -0.2 0.5 -0.4
Arm predicted mass (right) 0.3 1.4 3.4 -1.2 0.8 1.8 0.0 1.6 1.0 -0.7 1.6 -1.5 -0.6 0.5 1.5
Pulse rate, automated reading 0.3 1.1 8.1 0.6 0.1 -0.2 0.0 -0.2 -0.2 -2.8 -0.2 1.0 -0.9 1.6 -0.9
Alcohol intake frequency. 1.5 3.5 8.8 3.0 -1.5 -1.9 0.0 -1.9 -2.4 0.4 -1.9 2.7 -0.3 -0.1 -2.8
Comparative height size at age 10 0.2 1.0 3.1 -1.6 0.3 0.8 0.0 0.6 0.5 -0.1 0.6 -1.6 -0.4 1.5 1.8
Number of full sisters 3.9 4.8 8.7 -2.1 3.0 2.7 0.0 2.7 2.7 1.2 2.7 -1.9 -2.1 0.7 2.3
Suffer from ‘nerves’ 0.1 0.1 0.3 -0.1 0.5 0.2 0.0 0.4 0.2 0.6 0.4 -0.2 0.2 -0.6 0.5
Overall health rating 0.6 1.3 6.4 0.1 1.6 0.9 0.0 0.5 0.3 -2.5 0.5 0.4 -2.3 -0.1 -0.2
Chest pain or discomfort 0.4 0.6 1.5 -0.6 1.1 1.1 0.0 0.8 1.2 0.2 0.8 -0.6 -0.7 -1.1 0.3
Had major operations 1.3 1.5 6.9 -1.6 0.5 0.4 0.0 0.7 0.8 0.8 0.7 -1.7 0.1 1.9 2.6
Age at last live birth 0.8 1.2 2.3 -0.4 -1.0 -1.1 0.0 -1.2 -1.5 -1.4 -1.2 -0.6 0.9 -1.3 -1.4
Family relationship satisfaction 0.9 1.1 3.5 1.2 0.1 1.1 0.0 0.9 0.7 -1.7 0.9 0.9 -1.0 1.9 -0.5
Leg pain on walking 0.1 0.2 0.9 0.4 0.2 0.1 0.0 0.0 0.4 -0.5 0.0 0.1 -0.9 0.8 -0.4
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.2 -0.7 0.3 1.1 0.0 1.0 0.5 1.0 1.0 -0.9 0.4 -0.1 0.3
Commuting to job workplace: Car/motor vehicle 0.7 0.8 2.4 -0.5 1.3 1.0 0.0 0.9 0.2 -1.5 0.9 -0.6 -1.4 -0.5 0.2
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 1.6 0.0 -1.2 -1.3 0.0 -1.1 -1.1 0.6 -1.1 -0.5 0.9 0.4 -0.4
Medication: Aspirin 1.6 2.1 5.9 -2.4 1.4 0.7 0.0 0.8 1.1 0.6 0.9 -2.1 -1.4 1.6 2.2
Supplements: Vitamin C 0.1 0.1 0.8 -0.3 0.0 0.3 0.0 0.3 0.7 -0.1 0.3 -0.9 -0.2 -0.1 -0.1
Knee pain experienced in last month 1.1 1.7 3.3 1.3 -1.8 -1.6 0.0 -1.5 -1.8 0.8 -1.5 1.3 0.9 0.4 -1.4
Hypertension (Self-reported) 0.6 1.6 4.8 -1.4 2.2 1.7 0.0 1.6 0.9 -0.8 1.6 -0.8 -1.1 -1.0 0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 4.5 5.3 9.8 2.0 -3.0 -3.1 0.0 -3.1 -2.8 -1.0 -3.1 1.4 2.9 -0.5 -1.2
Illnesses of father: Heart disease 0.8 1.1 2.1 -1.1 1.3 1.4 0.0 1.1 1.2 -1.5 1.1 -1.4 -0.8 0.1 0.6
Illnesses of siblings: Diabetes 2.1 2.6 10.7 -0.1 2.2 1.6 0.0 1.9 1.9 -0.6 1.9 0.3 -3.3 1.1 -0.4
Smoking status: Previous 0.6 0.9 2.4 -0.5 -0.8 -1.6 0.0 -1.4 -1.0 -0.3 -1.3 -0.5 1.1 -0.8 -0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 2.3 0.6 -0.4 -0.2 0.0 -0.1 -0.2 -1.5 -0.1 0.3 0.1 -1.3 -1.2
Whole body fat-free mass 0.2 1.2 3.3 -1.0 0.4 1.7 0.0 1.4 0.6 -0.9 1.4 -1.2 -0.2 0.8 1.8
Leg fat-free mass (right) 0.3 1.8 5.3 -1.1 0.8 1.8 0.0 1.6 0.8 -1.4 1.6 -1.3 -0.5 1.2 2.3
Arm fat percentage (left) 0.1 0.3 2.0 0.1 0.2 -0.1 0.0 -0.2 -0.3 -1.4 -0.2 0.6 -0.8 0.8 0.0
Average weekly red wine intake 0.2 0.3 0.8 -0.2 -0.9 -0.7 0.0 -0.5 0.0 0.8 -0.5 -0.5 0.5 0.4 0.5
Handedness (chirality/laterality): Left-handed 0.7 0.8 2.1 -1.3 1.5 0.3 0.0 0.4 0.2 0.0 0.4 -1.5 -1.2 -1.4 0.5
Mood swings 0.5 0.8 5.4 0.6 -0.1 -0.5 0.0 -0.5 -0.2 -2.3 -0.5 0.4 -0.4 -0.6 -1.7
Loneliness, isolation 1.3 1.8 4.0 1.0 1.2 1.8 0.0 1.5 1.4 0.3 1.5 1.3 -1.8 -0.2 -2.0
Long-standing illness, disability or infirmity 0.3 0.5 1.5 0.3 -0.6 -0.8 0.0 -0.9 -1.2 0.2 -0.9 0.3 -0.2 1.2 -0.1
Ever had bowel cancer screening 0.5 0.6 1.0 -0.1 -0.8 -0.9 0.0 -0.9 -0.7 1.0 -0.9 -0.6 1.0 -0.7 0.9
Diabetes diagnosed by doctor 0.4 0.7 2.9 -0.3 1.3 0.7 0.0 0.6 0.6 -1.3 0.6 -0.2 -1.7 0.2 -0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 1.5 -0.3 -0.6 -0.7 0.0 -0.7 -0.6 0.2 -0.7 -0.3 1.2 0.7 0.5
Friendships satisfaction 1.8 2.2 7.0 0.5 1.0 2.1 0.0 1.9 1.6 -0.1 1.9 0.2 -1.5 2.6 1.1
Qualifications: nursing, teaching 0.4 0.6 1.8 -0.3 -0.9 -0.9 0.0 -0.9 -1.0 -0.0 -0.9 -0.6 0.9 0.3 1.3
Commuting to job workplace: Walk 0.6 0.7 1.5 0.6 -1.0 -1.2 0.0 -0.9 -1.0 0.9 -0.8 0.8 0.7 -0.1 -1.0
Eye problems/disorders: Cataract 1.0 1.1 7.0 1.4 -0.7 0.2 0.0 0.1 0.2 1.7 0.1 1.2 0.0 2.7 0.1
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 3.5 -1.1 0.1 -0.2 0.0 -0.3 -0.5 1.1 -0.3 -1.3 0.2 0.3 1.9
Medication for cholesterol 0.2 0.3 1.4 0.8 -0.3 -0.0 0.0 0.2 0.2 1.2 0.2 0.8 -0.0 0.1 -0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 1.4 0.5 -0.6 -0.8 0.0 -0.8 -0.8 -0.2 -0.8 0.5 1.2 -0.8 0.4
Back pain experienced in last month 2.5 3.6 6.9 2.3 -2.5 -2.2 0.0 -2.3 -2.6 1.1 -2.3 2.1 1.3 -0.5 -1.6
Mineral and other dietary supplements 0.5 0.7 2.7 1.4 -0.7 0.2 0.0 0.0 0.1 -0.3 0.0 1.6 0.9 1.6 -0.1
Breast cancer (self-reported) 0.7 0.8 2.0 0.9 -1.1 -0.8 0.0 -0.7 -0.5 -1.4 -0.7 0.5 1.3 1.3 0.8
Asthma (self-reported) 1.0 2.0 4.1 -1.6 1.8 1.2 0.0 1.6 2.0 -1.1 1.6 -1.4 -1.1 0.3 1.8
Osteoporosis (self-reported) 0.6 0.8 2.3 -0.6 -1.5 -1.2 0.0 -1.1 -0.7 -1.0 -1.1 -0.4 1.1 0.3 0.2
Osteoarthritis (self-reported) 1.7 2.2 4.9 0.7 -2.2 -2.0 0.0 -1.9 -1.7 1.5 -1.9 0.4 1.6 1.2 0.2
Medication: Aspirin 0.8 1.1 2.8 -1.7 1.0 0.5 0.0 0.5 0.9 0.3 0.5 -1.4 -1.1 1.2 1.6
Medication: Gliclazide 3.8 4.3 8.6 -0.9 2.6 2.9 0.0 2.9 2.5 0.6 2.8 -0.9 -2.9 1.4 1.1
Illnesses of father: None of the above (group 1) 0.5 0.6 1.9 0.2 -1.3 -0.9 0.0 -0.8 -1.0 0.2 -0.8 -0.2 1.4 -0.1 0.5
Smoking status: Current 0.6 1.0 2.3 1.5 -1.2 -0.8 0.0 -0.9 -0.5 -1.0 -0.9 1.5 0.7 -0.6 -1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.0 6.4 12.5 -1.8 3.2 3.4 0.0 3.5 3.2 -0.4 3.5 -1.3 -2.8 1.7 1.8
Whole body water mass 0.2 1.3 3.2 -1.0 0.6 1.8 0.0 1.5 0.7 -0.8 1.5 -1.2 -0.4 0.8 1.8
Leg predicted mass (right) 0.4 1.9 5.6 -1.1 0.8 1.9 0.0 1.7 0.8 -1.4 1.7 -1.3 -0.5 1.1 2.4
Arm fat mass (left) 0.1 0.3 1.5 -0.0 0.2 0.2 0.0 0.1 -0.1 -1.2 0.0 0.3 -0.7 0.9 0.4
Number of self-reported non-cancer illnesses 0.4 0.6 2.2 -1.3 0.7 -0.1 0.0 -0.1 -0.8 -0.4 -0.1 -1.1 -0.8 0.8 1.5
Average weekly champagne plus white wine intake 1.2 1.6 3.0 -1.0 1.7 1.5 0.0 1.7 1.6 1.4 1.7 -0.7 -1.1 -0.8 0.7
Miserableness 0.3 0.6 3.0 -0.6 0.5 0.5 0.0 0.3 0.6 -1.7 0.3 -0.9 -0.1 -1.3 -0.1
Guilty feelings 0.7 1.1 5.8 -0.1 0.5 -0.5 0.0 -0.6 -0.2 -1.1 -0.6 -0.1 -0.8 -2.1 -2.4
Wears glasses or contact lenses 0.5 0.6 2.0 -0.0 -0.7 -0.9 0.0 -0.9 -1.4 0.3 -0.9 -0.2 0.3 0.1 1.2
Ever taken oral contraceptive pill 2.0 2.2 4.7 -1.1 1.9 1.7 0.0 2.0 2.2 -0.5 2.0 -1.0 -1.9 -0.7 -0.8
Hearing aid user 0.1 0.2 0.4 0.4 -0.1 0.5 0.0 0.3 0.7 0.6 0.2 0.3 0.4 -0.4 -0.5
Mother’s age at death 0.4 0.4 1.7 -0.5 1.0 0.8 0.0 0.6 0.5 0.4 0.6 -0.5 -1.3 -0.2 0.1
Financial situation satisfaction 0.4 0.5 1.5 -1.0 0.6 0.7 0.0 0.6 0.6 -1.2 0.6 -1.1 -0.5 0.6 0.6
Tinnitus: Yes, now most or all of the time 0.4 0.5 2.9 0.8 -0.3 -0.1 0.0 0.1 0.3 1.7 0.1 0.8 -0.3 -0.1 -1.1
Commuting to job workplace: Public transport 0.6 0.8 3.0 1.3 -0.7 -0.9 0.0 -0.6 -0.5 0.2 -0.6 1.7 0.3 0.2 -1.4
Eye problems/disorders: Glaucoma 0.7 0.9 3.4 1.8 -0.6 -0.8 0.0 -0.7 -0.4 1.1 -0.7 1.7 0.1 0.8 -0.4
Medication: Blood pressure 0.1 0.3 1.3 0.6 0.6 0.1 0.0 -0.1 0.0 -0.1 -0.1 1.2 -0.3 -0.7 -0.8
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.8 -0.9 0.8 -0.6 0.0 -0.4 0.1 0.8 -0.4 -1.0 -0.8 -0.6 1.3
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.7 -1.0 0.7 0.1 0.0 0.2 0.3 -0.3 0.2 -1.1 -1.3 -0.9 -0.4
High cholesterol (Self-reported) 0.6 1.0 3.6 -1.5 0.3 -0.3 0.0 -0.2 -0.5 1.9 -0.2 -1.3 -0.4 1.3 1.4
Medication: Bendroflumethiazide 1.0 1.6 3.5 -0.5 -0.8 -1.9 0.0 -1.9 -1.6 -0.7 -1.9 -0.2 0.7 -1.8 -1.0
Medication: Paracetamol 0.6 1.0 2.1 0.5 -0.1 -1.1 0.0 -1.3 -1.2 -1.5 -1.3 0.5 -1.1 -0.4 -1.2
Medication: Lisinopril 0.6 0.8 3.5 0.9 0.2 -0.1 0.0 0.1 0.5 1.1 0.1 1.3 -1.3 0.1 -1.9
Medication: Atorvastatin 0.9 1.1 2.7 -0.6 1.6 1.6 0.0 1.6 1.2 1.1 1.6 -0.3 -0.7 0.3 0.4
Illnesses of father: High blood pressure 3.8 4.8 9.7 -1.5 2.7 3.1 0.0 2.9 3.1 0.4 2.9 -1.2 -2.2 1.9 1.2
Alcohol drinker status: Never 0.8 0.9 2.9 1.0 0.7 0.2 0.0 0.5 0.6 1.7 0.5 1.2 -1.5 1.4 -0.2
Ever smoked 0.6 1.0 3.2 -0.1 -1.3 -1.2 0.0 -1.1 -0.1 -1.6 -1.1 -0.3 1.8 -0.9 -0.2
Basal metabolic rate 0.2 1.0 2.6 -0.8 0.5 1.6 0.0 1.4 0.6 -0.9 1.4 -1.0 -0.3 0.7 1.5
Leg fat percentage (left) 0.2 0.6 2.6 0.8 -0.3 -0.8 0.0 -0.7 -0.3 -0.9 -0.7 1.1 -0.5 -0.2 -1.6
Arm fat-free mass (left) 0.1 0.5 1.7 -0.5 0.4 1.3 0.0 1.1 0.5 -0.3 1.1 -0.7 -0.5 0.1 0.8
Number of operations (self-reported) 1.1 1.6 5.4 -1.7 -0.2 -0.8 0.0 -0.7 -0.4 1.0 -0.7 -1.7 -0.2 2.2 2.3
Average weekly beer plus cider intake 0.1 0.2 0.4 -0.6 0.4 0.6 0.0 0.4 0.2 -0.0 0.5 -0.4 0.3 -0.1 0.4
Irritability 0.9 1.5 3.0 -0.5 -1.4 -1.4 0.0 -1.4 -1.0 -1.5 -1.4 -1.0 1.7 -1.5 -0.5
Risk taking 0.6 0.9 3.9 0.1 -1.2 -0.4 0.0 -0.7 -1.0 -2.0 -0.7 -0.3 1.4 1.1 0.2
Ever had prostate specific antigen (PSA) test 1.5 1.7 7.8 0.9 -1.6 -1.4 0.0 -1.4 -1.0 2.8 -1.4 1.2 1.0 0.2 -0.1
Fractured/broken bones in last 5 years 0.2 0.2 1.7 -0.2 0.8 0.4 0.0 0.2 0.2 -0.4 0.1 -0.2 -0.2 -1.3 0.1
Age started oral contraceptive pill 0.0 0.1 0.2 -0.2 0.1 0.3 0.0 0.4 0.3 0.3 0.4 -0.1 0.0 0.2 0.2
Diastolic blood pressure, automated reading 0.2 0.7 3.4 1.3 -0.4 -0.1 0.0 -0.4 -0.6 -1.9 -0.4 1.6 0.3 0.3 -0.0
Ever depressed for a whole week 0.5 0.6 1.6 -0.9 1.1 1.2 0.0 1.0 0.7 -0.1 1.0 -0.8 -1.0 0.3 0.3
Unable to work because of sickness or disability 0.6 0.7 2.7 -0.9 1.6 0.8 0.0 0.6 0.5 0.9 0.6 -0.5 -1.4 -0.6 0.8
Commuting to job workplace: Cycle 1.4 1.7 5.2 0.0 0.7 1.7 0.0 1.6 1.4 1.8 1.6 -0.2 0.8 0.9 2.3
Myopia 0.4 0.5 1.5 -0.9 0.9 0.6 0.0 0.3 0.1 0.7 0.3 -0.5 -1.2 -1.1 0.8
Vascular/heart problems diagnosed by doctor 0.5 1.3 3.8 1.6 -1.9 -1.2 0.0 -1.1 -0.8 0.0 -1.1 0.9 1.5 1.3 -0.0
Cholesterol lowering medication 0.1 0.2 0.8 0.5 -0.2 -0.3 0.0 -0.4 -0.3 0.9 -0.4 0.8 0.3 -0.4 -0.1
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.4 -0.0 -0.5 -1.1 0.0 -0.9 -1.2 -0.8 -0.8 -0.2 0.7 -0.9 -1.2
Pain experienced in last month 1.5 2.5 5.4 -1.5 1.7 2.1 0.0 2.3 2.2 0.8 2.3 -1.2 -0.3 0.8 1.3
Supplements: Calcium 0.6 0.6 1.4 0.6 -0.9 -1.1 0.0 -1.0 -1.2 0.5 -1.1 0.2 0.1 -0.8 -0.7
Basal cell carcinoma (self-reported) 0.4 0.5 3.1 0.7 0.2 0.3 0.0 0.4 0.3 -1.7 0.4 0.5 0.2 0.7 -1.0
Heart attack/myocardial infarction (self-reported) 0.9 1.2 4.8 -1.9 1.7 0.1 0.0 0.4 0.6 0.1 0.4 -1.4 -2.2 -1.0 0.2
Deep venous thrombosis (DVT) (self-reported) 0.5 0.7 4.9 0.3 0.9 0.6 0.0 0.7 0.2 -2.2 0.7 0.3 -0.8 -0.5 0.1
Heart disease (siblings) 1.0 1.2 3.0 0.5 -1.2 -1.7 0.0 -1.7 -1.7 0.3 -1.7 0.5 0.6 -0.9 -0.3
Alcohol drinker status: Previous 0.8 1.0 2.4 0.2 -0.5 -1.4 0.0 -1.4 -1.5 -1.1 -1.4 0.3 0.3 -0.5 -1.0
Pack years of smoking 0.2 0.3 1.3 0.2 -0.9 -0.6 0.0 -0.4 0.4 0.1 -0.4 -0.2 0.9 -0.3 1.1
Impedance of whole body 0.5 2.6 4.8 1.7 -2.1 -2.2 0.0 -1.9 -1.1 1.0 -2.0 1.4 2.2 -0.7 -1.5
Leg fat mass (left) 0.1 0.2 1.3 0.3 -0.4 -0.4 0.0 -0.4 -0.3 -1.1 -0.4 0.3 -0.3 0.5 -0.4
Arm predicted mass (left) 0.1 0.7 2.0 -0.9 0.6 1.4 0.0 1.1 0.6 -0.2 1.1 -1.1 -0.5 -0.0 1.0