Hub : Genes

ADSSL1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0540 0.0210 4.3e-03 0.010 0.014 0.010 0.015 0.012 2.1e-02 6.7e-03 1.9e-02 0.0055 1.1e-02
2 GTEx Cells Transformed fibroblasts 0.1250 0.0420 4.7e-04 0.047 NA 0.050 NA 0.047 2.0e-04 NA 1.2e-04 NA 1.8e-04
3 GTEx Esophagus Mucosa 0.2710 0.0520 1.6e-10 0.218 NA 0.188 NA 0.208 1.3e-14 NA 1.2e-12 NA 6.0e-14
4 GTEx Esophagus Muscularis 0.1420 0.0500 1.5e-03 0.102 NA 0.076 NA 0.093 9.3e-07 NA 2.4e-05 NA 3.0e-06
5 GTEx Skin Not Sun Exposed Suprapubic 0.3160 0.0620 1.2e-08 0.155 NA 0.205 NA 0.202 7.7e-09 NA 1.8e-11 NA 2.7e-11
6 GTEx Skin Sun Exposed Lower leg 0.2350 0.0500 3.6e-10 0.217 NA 0.175 NA 0.096 7.2e-18 NA 2.0e-14 NA 2.6e-08
7 GTEx Testis 0.5110 0.0570 0.0e+00 0.557 NA 0.594 NA 0.575 2.9e-29 NA 3.5e-32 NA 1.3e-30
8 TCGA Kidney Renal Papillary Cell Carcinoma 0.1360 0.0690 6.2e-03 0.018 -0.004 -0.003 NA 0.022 3.1e-02 7.0e-01 5.1e-01 NA 1.9e-02
9 TCGA Prostate Adenocarcinoma 0.0571 0.0268 3.7e-05 0.054 0.040 0.024 NA 0.044 2.5e-06 4.2e-05 1.3e-03 NA 1.9e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 0.8 1.3 3.9 0.0 -2.0 -1.1 -1.1 -1.4 -1.1 1.6 0.0 0.0
Bipolar Disorder or Schizophrenia 1.1 2.6 5.1 -1.9 -2.3 -1.5 -1.5 -2.0 -1.7 2.0 0.0 0.0
Depressed Affect (Nagel 2018) 0.2 0.4 1.4 1.1 0.4 -0.2 -0.1 0.4 -0.1 0.1 -1.2 -0.6
Depression (Nagel 2018) 0.7 1.1 2.3 1.5 1.5 0.8 0.7 1.3 0.8 -0.9 -0.8 0.5
Intelligence (Savage-Jansen 2018) 0.2 0.5 1.3 0.8 0.6 0.2 0.2 1.2 0.1 -0.7 -1.0 0.6
Neuroticism (Nagel 2018) 0.2 0.5 2.2 1.5 0.2 -0.3 -0.2 0.1 -0.3 0.3 -1.0 -0.9
Schizophrenia (2018) 0.7 1.4 3.6 -1.9 -1.3 -1.0 -1.1 -1.4 -1.3 1.3 0.0 0.0
Schizophrenia vs Biploar Disorder 0.1 0.1 0.6 -0.8 -0.1 -0.2 0.1 0.0 -0.2 0.2 0.0 0.0
Worry (Nagel 2018) 0.2 0.5 1.4 0.5 -0.2 -0.7 -0.6 -0.3 -0.7 0.6 -1.2 -1.0
Alzheimer’s Disease (in mother) 0.2 0.2 0.4 -0.3 -0.3 -0.5 -0.5 -0.0 -0.5 0.7 0.5 -0.3
Alzheimer’s Disease (in father) 0.1 0.1 0.7 -0.2 -0.1 -0.1 -0.3 0.2 -0.1 0.0 -0.9 -0.1
Alzheimer’s Disease (including proxy) 0.7 1.1 1.8 0.1 -0.9 -1.3 -1.3 -0.5 -1.2 1.3 -0.8 -1.2
Crohns Disease (2017) 0.1 0.3 1.0 1.0 0.4 0.2 0.0 0.2 0.2 -0.6 -0.9 0.1
Irritable Bowel Disease (IBD) 0.3 0.8 1.6 0.3 -1.1 -0.9 -0.9 -1.3 -0.9 0.7 -0.6 -0.7
Ulcerative Colitis (UC) 1.6 3.1 5.6 -0.5 -2.4 -1.8 -1.7 -2.3 -2.0 1.9 -0.6 -1.5
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 2.4 4.5 10.7 3.3 1.8 2.2 2.1 1.6 2.1 -2.4 0.1 2.0
Verbal and Numeric Reasoning (VNR) 0.4 1.0 1.8 -0.7 -0.9 -1.3 -1.3 -0.4 -1.4 1.0 -0.8 -0.7
Breast Cancer 9.6 23.1 30.6 3.5 5.3 5.2 5.5 5.3 5.4 -4.9 1.8 5.1
Ovarian Cancer 1.5 2.0 3.1 0.5 1.6 1.6 1.5 0.7 1.8 -1.4 1.3 1.7
Prostate Cancer 2.0 2.9 5.5 -0.1 -1.0 -1.9 -1.7 -1.6 -1.9 1.6 -2.3 -2.0
Age at First Birth 1.6 2.4 4.0 -1.4 -1.7 -1.8 -2.0 -1.5 -1.9 1.8 0.0 0.0
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.3 0.4 1.8 -1.4 -0.1 0.3 0.2 1.1 0.3 -0.3 0.0 0.0
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.3 0.5 1.7 0.1 0.8 0.5 0.4 1.3 0.6 -1.0 0.0 0.0
Mean Putamen Volume 2.5 2.9 7.9 0.0 -1.3 -1.8 -1.7 -0.9 -1.8 1.3 -2.8 -2.0
Fasting Glucose 0.2 0.3 1.4 0.3 -0.1 -0.5 -0.3 -1.2 -0.4 0.7 0.0 0.0
HbA1C 2.1 2.3 3.9 1.0 1.7 1.8 1.7 2.0 1.7 -2.0 0.0 0.0
HDL Cholesterol 1.2 2.0 7.0 -2.6 -1.7 -1.3 -1.2 -1.0 -1.3 1.4 0.0 0.0
LDL Cholesterol 0.4 0.6 0.9 0.6 -0.9 -1.0 -0.9 -0.6 -0.9 1.0 0.0 0.0
Lupus 0.1 0.2 0.5 -0.1 0.4 0.3 0.5 0.6 0.4 -0.3 0.4 0.7
Neuroticism (2016) 0.8 1.2 2.0 1.2 -1.3 -1.0 -0.9 -0.7 -1.3 0.8 -1.0 -1.4
Primary Biliary Cirrhosis 1.8 2.6 5.6 -2.4 -2.1 -1.4 -1.4 -1.4 -1.5 1.8 0.7 -1.3
Rheumatoid Arthritis 0.6 0.8 1.8 0.6 -0.4 -1.2 -0.9 -1.1 -1.1 1.3 0.0 0.0
Schizophrenia (2014) 0.6 1.3 2.7 -1.6 -1.4 -1.0 -1.1 -1.1 -1.1 1.3 0.0 0.0
Triglycerides 1.0 1.7 3.9 1.1 1.7 1.2 1.4 2.0 1.2 -1.5 0.0 0.0
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ulcerative Colitis 2.0 2.8 5.4 -1.8 -2.3 -1.6 -1.7 -1.9 -1.8 2.0 0.0 0.0
Blood Eosinophil Count 0.1 1.0 2.4 0.9 0.8 1.1 0.9 0.5 1.2 -0.8 1.6 1.1
Blood Platelet Count 0.5 5.3 20.5 4.5 3.0 1.8 1.3 1.8 1.9 -1.7 -0.4 1.9
Blood Red Count 0.8 7.9 21.3 -4.6 -3.1 -2.3 -2.5 -3.1 -2.4 2.8 1.3 -1.9
Blood White Count 1.8 13.6 36.0 6.0 3.8 3.5 3.1 3.8 3.4 -3.4 0.1 3.4
Heel T-Score 0.1 0.6 1.7 1.0 -0.3 -0.6 -0.9 -1.3 -0.6 0.8 -0.7 -0.4
BMI 0.4 2.3 5.3 2.3 0.9 1.6 1.1 1.8 1.4 -1.3 1.1 1.7
Height 0.0 0.9 2.8 -1.7 -1.1 -0.7 -0.8 -0.6 -0.8 0.9 0.8 -0.6
Waist Hip Ratio (WHR) 0.3 1.4 3.6 1.9 1.0 1.1 1.2 0.7 1.2 -0.8 1.3 1.1
Systolic Blood Pressure 0.3 1.6 10.6 3.3 0.9 0.5 0.5 0.6 0.4 -0.6 -1.0 0.1
Smoking Status 0.3 0.8 1.2 -1.1 -0.7 -0.9 -1.0 -0.9 -0.9 0.9 -0.5 -1.1
Allergy or Eczema 0.3 0.9 5.4 -2.3 -0.5 0.2 0.3 0.8 0.2 -0.4 1.1 0.6
Cardiovascular Disease 1.2 4.0 5.9 2.4 2.3 2.1 2.0 1.9 2.0 -2.2 0.1 1.9
Hypothyroidism (self reported) 3.4 7.8 11.6 0.7 2.6 3.2 2.8 3.2 3.2 -3.2 1.5 3.4
Respiratory disease 0.9 2.0 3.1 -0.1 1.4 1.7 1.6 1.4 1.7 -1.8 0.6 1.6
Type 2 Diabetes (T2D) (2018) 2.5 4.8 12.9 3.6 2.4 2.0 1.7 2.5 1.9 -2.0 -0.7 1.8
Lung FEV1/FVC ratio 2.3 11.4 14.3 3.7 3.7 3.8 3.4 3.0 3.6 -3.6 1.7 3.4
Lung FVC 2.1 10.8 16.5 -0.6 3.2 3.7 4.1 2.7 4.0 -3.6 2.6 3.7
Neuroticism 0.4 1.1 2.0 0.7 -0.5 -1.1 -1.3 -0.6 -1.2 1.0 -1.4 -1.3
Chronotype (morning person) 2.4 5.5 7.6 -0.8 2.2 2.7 2.5 2.7 2.7 -2.6 1.2 2.8
Hair Pigment 0.1 2.4 4.1 -0.7 1.6 1.7 1.5 1.8 1.6 -2.0 0.2 1.9
Tanning 0.1 1.2 6.1 -2.5 -0.9 -0.8 -0.9 -0.3 -0.8 1.0 0.7 -0.6
Hand grip strength (left) 0.7 1.8 6.7 -2.3 -0.2 0.7 0.7 -0.0 0.7 -0.4 2.6 1.4
Number of treatments/medications taken 1.1 1.9 10.6 2.2 -0.1 -0.6 -0.7 0.2 -0.6 -0.0 -3.2 -0.9
Average weekly spirits intake 1.8 2.3 5.0 0.3 1.3 1.7 1.8 1.2 1.5 -1.9 0.3 2.2
Sensitivity / hurt feelings 0.6 1.0 2.0 -0.1 1.0 1.2 1.0 0.8 1.1 -0.9 1.4 0.9
Frequency of depressed mood in last 2 weeks 0.9 1.2 4.1 2.0 1.1 0.9 0.7 1.2 0.6 -1.1 -0.9 0.7
Hearing difficulty/problems: Yes 0.7 1.1 1.4 -1.1 0.8 1.1 1.1 1.2 1.1 -0.9 1.1 1.0
Relative age of first facial hair 1.4 2.9 6.9 -1.4 1.1 1.6 1.8 1.0 1.7 -1.0 2.6 2.2
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 3.5 0.7 0.5 0.2 -0.2 0.8 0.1 -0.8 -1.9 0.8
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.4 -0.5 -0.6 -0.6 -0.2 -0.5 -0.4 0.3 -0.5 -0.6
Ever had hysterectomy (womb removed) 2.6 3.0 4.4 -0.3 -1.6 -2.0 -1.8 -1.8 -1.9 2.1 -1.3 -2.1
Systolic blood pressure, automated reading 0.4 1.3 7.9 2.8 -0.2 -0.6 -0.6 -0.4 -0.6 0.6 -1.1 -0.9
Eye problems/disorders: Diabetes related eye disease 1.5 1.7 6.5 2.5 1.3 1.2 1.1 0.9 1.0 -1.2 -0.1 0.9
Angina 1.1 1.4 2.6 0.8 1.2 1.2 1.2 1.5 1.1 -1.6 -1.0 0.9
Medication for hormone replacement therapy 0.2 0.3 0.5 -0.6 -0.4 -0.6 -0.5 -0.4 -0.6 0.4 -0.1 -0.7
Vitamin and mineral supplements 0.4 0.6 2.0 -0.9 -1.1 -0.4 -0.4 -0.3 -0.3 0.9 1.4 -0.2
Supplements: Zinc 0.4 0.4 0.8 0.1 -0.7 -0.7 -0.6 -0.3 -0.8 0.3 -0.9 -0.8
Medication: Co-codamol 1.1 1.2 4.1 1.2 0.8 0.7 0.7 1.4 0.8 -0.8 -2.0 0.8
Medication: Metformin 1.9 2.7 9.0 3.0 1.2 1.4 1.3 1.8 1.4 -1.7 -0.8 1.0
Diabetes (father) 0.7 0.9 2.7 1.5 0.5 0.6 0.3 1.0 0.4 -1.1 -1.6 0.6
Diabetes (mother) 2.5 3.2 7.2 2.2 2.7 1.5 1.2 1.6 1.4 -1.9 -1.7 1.5
Severe depression (siblings) 0.2 0.3 1.6 -1.3 -0.1 0.1 0.0 -0.4 0.1 0.4 0.8 0.2
Pack years adult smoking proportion 0.3 0.4 0.9 -0.8 -0.7 -0.6 -0.2 -0.6 -0.5 0.7 0.9 -0.4
Impedance of leg (right) 0.3 1.5 2.6 -1.1 -1.0 -1.3 -1.1 -1.4 -1.3 1.6 0.3 -1.3
Leg fat-free mass (left) 0.5 2.6 3.9 1.0 0.9 1.9 1.6 1.6 1.8 -1.7 2.0 1.8
Trunk fat percentage 0.1 0.6 2.1 1.5 -0.7 -0.6 -0.7 0.0 -0.7 0.7 -0.7 -0.5
Hand grip strength (right) 1.2 3.3 7.6 -2.8 0.6 1.6 1.6 0.8 1.6 -1.4 2.4 2.5
Townsend deprivation index at recruitment 0.3 0.5 1.0 -0.3 0.6 0.5 0.6 0.7 0.6 -0.5 1.0 1.0
Current tobacco smoking 0.2 0.3 0.7 -0.6 -0.6 -0.4 -0.3 -0.9 -0.4 0.7 0.4 -0.4
Average weekly fortified wine intake 0.2 0.2 1.2 0.6 1.1 -0.0 -0.1 -0.5 -0.0 0.1 -0.4 0.2
Maternal smoking around birth 0.1 0.1 0.3 -0.2 0.3 0.3 0.4 0.0 0.5 -0.5 -0.1 0.2
Fed-up feelings 0.6 1.0 6.0 1.3 0.6 -0.4 -0.4 0.1 -0.3 -0.1 -2.5 -0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.3 3.5 1.9 1.2 1.0 0.8 0.9 0.9 -1.2 -0.6 1.2
Relative age voice broke 0.8 1.1 4.2 -1.7 0.5 0.6 0.8 -0.0 0.7 -0.1 2.1 1.2
Taking other prescription medications 0.5 0.8 3.7 1.5 0.1 0.0 -0.4 0.9 -0.1 -0.3 -1.9 0.2
Age when periods started (menarche) 0.2 0.6 1.5 0.3 -0.5 -0.8 -0.6 -0.6 -0.7 1.0 1.2 -0.6
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.6 0.8 0.2 0.5 0.7 0.3 0.5 -0.3 -0.0 0.2
Heel bone mineral density (BMD) T-score, automated (left) 1.3 2.9 3.9 2.0 2.0 1.8 1.6 1.4 1.8 -1.5 0.8 2.0
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 1.7 -0.8 -0.5 0.2 0.2 0.1 0.3 0.1 1.3 -0.0
Qualifications: CSEs or equivalent 1.3 1.7 2.9 1.1 1.4 1.4 1.3 1.7 1.2 -1.5 0.1 1.3
Serious illness, injury or assault to yourself 1.5 1.8 11.2 1.4 0.5 -0.8 -0.7 0.5 -0.7 -0.1 -3.4 -1.1
High blood pressure 1.1 2.9 11.0 3.3 1.8 1.3 1.4 1.5 1.4 -1.6 -1.1 0.6
Hayfever, allergic rhinitis or eczema 0.6 1.3 7.3 -2.7 -0.7 0.2 0.3 0.6 0.2 -0.1 1.9 0.5
Multivitamins +/- minerals 0.4 0.5 2.3 1.4 0.6 0.0 0.0 0.1 0.0 -0.4 -1.5 -0.2
Stomach or abdominal pain in last month 0.2 0.2 0.7 0.9 0.5 0.3 0.5 -0.3 0.4 -0.4 -0.3 -0.0
Supplements: Glucosamine 0.2 0.3 1.1 -1.0 -0.3 -0.0 0.2 -0.6 -0.0 -0.1 1.0 -0.1
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 0.9 0.0 -0.6 -0.4 -0.3 -0.8 -0.6 0.8 0.9 -0.5
Medication: Atenolol 0.5 0.7 1.3 0.5 -0.8 -0.7 -1.1 -0.2 -0.9 0.7 -1.1 -0.8
Medication: Levothyroxine sodium 2.9 4.9 7.4 0.5 2.3 2.4 2.2 2.5 2.5 -2.7 -0.1 2.7
Sitting height 0.3 1.9 10.2 -1.3 -0.1 1.0 1.1 -0.5 1.0 -0.6 3.2 1.0
Chronic bronchitis/emphysema (father) 0.8 1.0 1.9 -0.5 -1.4 -1.2 -1.1 -0.5 -0.9 1.0 -0.9 -1.1
High blood pressure (mother) 1.0 1.4 2.7 0.7 1.5 1.2 1.6 1.3 1.3 -1.3 -0.0 1.0
Body mass index (BMI) 0.2 1.0 5.4 2.3 0.4 0.7 0.4 1.3 0.6 -0.7 -0.5 0.5
Impedance of leg (left) 0.5 2.4 3.6 -1.6 -1.4 -1.7 -1.4 -1.7 -1.7 1.9 -0.1 -1.6
Leg predicted mass (left) 0.5 2.6 4.0 0.9 0.9 1.9 1.7 1.6 1.8 -1.7 2.0 1.8
Trunk fat mass 0.1 0.3 1.8 1.3 -0.7 -0.2 -0.4 0.2 -0.3 0.4 0.1 -0.2
Waist circumference 0.1 0.5 3.8 2.0 0.2 0.3 0.1 0.4 0.3 -0.1 0.3 0.1
Number of incorrect matches in round 0.3 0.5 2.9 -1.7 -0.2 0.1 0.2 -0.4 0.0 -0.1 1.0 0.4
Past tobacco smoking 1.6 3.0 4.4 1.4 1.1 1.9 2.0 1.8 1.9 -1.6 1.5 2.1
Alcohol usually taken with meals 0.6 0.9 1.9 1.2 0.9 1.0 0.7 1.2 1.0 -1.4 -0.1 0.4
Nervous feelings 1.3 2.3 3.7 1.9 1.7 1.7 1.6 1.3 1.7 -1.7 -0.3 1.3
Frequency of tenseness / restlessness in last 2 weeks 1.5 2.4 6.6 2.6 1.7 1.2 1.1 1.8 1.2 -1.5 -1.2 0.8
Hearing difficulty/problems with background noise 0.1 0.2 0.8 -0.5 -0.2 -0.3 -0.9 -0.3 -0.5 0.5 0.1 0.0
Hair/balding pattern: Pattern 2 0.9 1.2 4.9 2.0 1.0 -0.1 -0.2 0.2 -0.0 -0.3 -2.2 -0.6
Had menopause 1.0 1.2 1.5 -1.0 -1.1 -1.2 -1.2 -1.2 -1.1 1.2 -0.5 -1.2
Had other major operations 0.4 0.5 1.2 -1.0 -0.6 -0.6 -0.7 -0.9 -0.6 0.4 -1.1 -0.1
Forced vital capacity (FVC) 2.0 7.8 11.2 -0.0 2.3 3.2 3.3 2.1 3.3 -2.8 3.3 3.1
Heel bone mineral density (BMD) T-score, automated (right) 1.5 3.5 5.9 2.4 2.2 2.0 1.8 1.4 2.0 -1.6 0.3 2.1
Ever unenthusiastic/disinterested for a whole week 1.9 2.3 4.0 2.0 1.8 1.5 1.7 1.5 1.6 -1.6 0.2 1.1
Qualifications: None of the above 0.3 0.7 1.4 -0.4 -0.9 -0.8 -0.6 -1.0 -0.7 1.2 -0.1 -1.1
Financial difficulties in last 2 years 3.8 5.1 7.3 0.6 2.4 2.5 2.3 2.7 2.5 -2.6 1.2 2.5
Mouth/teeth dental problems 0.2 0.3 1.5 1.2 0.4 0.4 0.3 0.4 0.3 -0.4 0.2 0.4
Heart attack 1.0 1.2 5.8 1.3 1.0 0.2 0.5 1.2 0.4 -0.9 -2.4 -0.3
Allergy 0.2 0.5 1.5 1.2 0.2 -0.4 -0.5 -0.7 -0.5 0.4 -1.1 -0.5
Pain all over the body in last month 1.5 1.6 2.7 1.3 1.5 1.3 1.3 0.8 1.1 -1.4 -1.0 1.6
Diabetes (self-reported) 0.9 1.4 7.5 2.7 0.9 0.6 0.5 1.1 0.6 -0.8 -1.0 0.1
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 0.8 -0.4 -0.9 -0.0 0.2 -0.3 -0.1 0.3 0.9 -0.3
Medication: Ramipril 0.6 0.8 3.6 1.6 0.8 -0.2 -0.1 0.5 -0.1 -0.2 -1.9 -0.2
Medication: Simvastatin 0.5 0.7 2.8 1.4 -0.6 -0.6 -0.5 -0.1 -0.6 -0.1 -1.7 -0.8
Fluid intelligence score 0.2 0.4 1.3 0.9 0.5 0.1 0.2 0.9 0.0 -0.4 -1.1 0.6
Illnesses of siblings 0.2 0.3 2.4 -0.2 0.1 0.2 -0.1 -0.2 0.2 0.1 1.6 0.4
Neuroticism score 0.2 0.4 1.2 1.1 0.2 -0.3 -0.3 -0.2 -0.3 0.1 -1.1 -0.7
Weight 0.1 0.7 2.3 1.5 -0.0 0.8 0.5 0.9 0.7 -0.6 1.0 0.6
Impedance of arm (right) 0.5 2.4 4.6 -1.1 -1.4 -1.7 -1.4 -2.1 -1.8 1.9 -0.1 -1.3
Arm fat percentage (right) 0.2 0.7 4.7 2.2 -0.5 -0.3 -0.5 0.4 -0.4 0.3 -0.9 -0.3
Trunk fat-free mass 0.3 1.5 5.2 0.0 0.2 1.4 1.0 0.9 1.3 -1.2 2.3 1.0
Hip circumference 0.1 0.5 1.9 1.4 -0.4 0.5 0.3 0.5 0.4 -0.0 1.2 0.3
Time employed in main current job 2.0 2.3 3.8 -1.4 -1.1 -1.6 -2.0 -1.3 -1.7 1.8 -1.5 -1.2
Alcohol intake versus 10 years previously 0.1 0.2 0.9 0.5 -0.4 -0.4 -0.3 -0.3 -0.4 0.1 -1.0 -0.4
Father’s age at death 0.2 0.3 1.7 -1.3 -0.6 -0.4 -0.6 -0.3 -0.5 0.2 -0.2 -0.1
Worrier / anxious feelings 0.2 0.3 0.8 0.9 0.1 -0.5 -0.2 -0.6 -0.5 0.4 -0.9 -0.7
Frequency of tiredness / lethargy in last 2 weeks 1.9 3.0 14.2 3.8 1.6 0.8 0.7 1.5 0.6 -1.2 -2.3 0.4
Falls in the last year 1.9 2.6 4.1 1.2 1.8 1.9 2.0 1.3 2.0 -1.7 0.5 1.7
Hair/balding pattern: Pattern 3 0.1 0.2 0.5 0.0 -0.5 0.3 0.3 0.7 0.2 -0.2 0.5 0.6
Number of live births 0.2 0.3 0.9 -0.9 0.2 -0.3 -0.6 -0.6 -0.2 0.2 0.3 -0.6
Forced expiratory volume in 1-second (FEV1) 4.8 16.0 21.9 0.8 3.5 4.6 4.7 3.5 4.7 -4.2 4.0 4.5
Pulse rate 0.3 0.5 1.3 0.5 -0.7 -0.6 -0.4 -1.1 -0.5 0.8 0.0 -0.8
Happiness 0.1 0.1 0.6 0.8 0.1 -0.2 -0.1 0.2 -0.2 0.2 -0.6 -0.4
Noisy workplace 0.5 0.6 1.1 0.9 0.7 1.0 0.8 0.5 1.0 -1.0 -0.3 0.7
Qualifications: A levels/AS levels or equivalent 0.4 0.9 2.0 -0.1 0.9 1.0 0.9 0.4 0.9 -0.9 1.4 1.2
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.4 -0.0 0.3 0.2 0.6 0.6 0.2 -0.1 0.5 -0.3
Mouth/teeth dental problems: Dentures 1.8 3.0 4.2 -1.8 -1.8 -1.7 -1.8 -2.0 -1.7 1.7 -1.1 -1.8
Asthma 1.2 2.3 3.5 1.0 1.5 1.7 1.9 1.2 1.8 -1.9 0.0 1.5
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 0.7 -0.4 -0.5 -0.9 -0.6 -0.5 -0.8 0.8 -0.5 -0.9
Medication: Cholesterol lowering 1.5 2.3 5.6 2.4 1.0 0.8 0.9 1.9 0.9 -1.7 -2.3 0.4
Depression (self-reported) 0.7 0.8 1.6 0.7 0.5 1.1 1.2 0.7 1.0 -1.0 0.5 1.1
Medication: Lansoprazole 0.6 0.7 4.1 0.9 0.1 -0.4 -0.5 0.4 -0.5 0.1 -2.0 -0.3
Prospective memory result 0.1 0.1 0.2 0.2 -0.3 0.3 0.5 -0.1 0.2 -0.4 0.5 0.3
Lung cancer (father) 3.5 4.1 6.2 -0.1 -2.2 -2.2 -2.2 -2.2 -2.1 2.2 -1.4 -2.5
Illnesses of mother 0.6 0.8 3.8 -1.1 -0.2 0.6 0.2 -0.1 0.4 -0.2 2.0 1.1
Forced expiratory volume in 1-second (FEV1), Best measure 5.8 18.5 26.0 1.5 4.1 5.0 5.1 4.0 5.1 -4.7 3.3 4.8
Pulse wave Arterial Stiffness index 2.1 2.4 4.1 0.3 -1.5 -1.7 -1.5 -1.5 -1.7 1.4 -2.0 -1.8
Impedance of arm (left) 0.5 2.1 4.1 -1.0 -1.4 -1.6 -1.2 -2.0 -1.7 1.9 -0.0 -1.3
Arm fat mass (right) 0.1 0.5 3.9 2.0 -0.2 0.2 -0.0 0.7 0.1 -0.2 -0.3 0.2
Trunk predicted mass 0.3 1.5 4.9 0.1 0.3 1.4 1.0 1.0 1.4 -1.2 2.2 1.1
Standing height 0.2 1.9 10.5 -2.1 -1.0 0.3 0.4 -0.8 0.2 0.2 3.2 0.3
Length of working week for main job 0.4 0.4 1.0 -0.2 0.2 0.7 0.8 0.4 0.8 -0.5 1.0 0.8
Exposure to tobacco smoke at home 0.6 0.7 2.6 -1.6 -0.5 -0.5 -0.5 -0.7 -0.6 0.8 1.0 -0.3
Breastfed as a baby 0.1 0.1 0.3 0.1 -0.3 -0.3 -0.2 0.0 -0.2 0.3 -0.5 -0.4
Tense / ‘highly strung’ 0.4 0.6 1.6 -0.4 -0.4 -0.9 -0.5 -0.4 -0.6 0.4 -1.3 -1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.7 4.1 1.0 2.0 1.2 1.4 1.2 1.4 -1.4 0.5 1.0
Hair/balding pattern: Pattern 4 0.0 0.0 0.2 -0.4 0.1 -0.0 -0.1 0.0 -0.0 0.0 0.3 0.1
Birth weight of first child 1.0 1.7 2.6 -1.0 1.0 1.3 1.2 1.3 1.4 -1.3 1.5 1.6
Peak expiratory flow (PEF) 3.8 8.8 12.7 -1.0 2.0 3.4 3.3 2.5 3.4 -3.2 3.4 3.6
Pulse wave reflection index 0.2 0.2 0.9 0.3 -0.3 -0.4 -0.6 -0.1 -0.6 0.3 -0.9 -0.2
Ever highly irritable/argumentative for 2 days 1.2 1.5 4.0 2.0 1.4 1.0 1.3 1.4 1.2 -1.0 -0.1 0.5
Loud music exposure frequency 0.2 0.3 2.0 -1.4 -0.3 -0.2 -0.1 0.3 -0.2 -0.1 -0.1 -0.2
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.7 0.8 0.7 0.3 0.3 0.3 0.2 -0.7 -0.8 0.5
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 3.4 -0.5 0.5 0.8 1.0 0.8 1.0 -0.5 1.8 0.9
Blood clot in the leg (DVT) 1.0 1.3 7.1 2.7 1.0 0.6 0.6 1.3 0.7 -0.6 -0.5 0.2
Medication: Paracetamol 0.6 1.0 4.1 2.0 0.5 -0.3 -0.2 -0.4 -0.4 0.1 -2.0 -0.5
Headache pain in last month 0.6 1.0 1.4 0.7 -0.4 -1.1 -1.2 -0.7 -1.2 1.1 -1.2 -1.0
Medication for cholesterol, blood pressure or diabetes 0.7 1.1 5.5 -2.4 -0.6 -0.3 -0.3 -1.3 -0.4 0.8 1.2 0.0
Glaucoma (self-reported) 0.2 0.2 0.5 -0.7 -0.4 -0.5 -0.4 -0.4 -0.3 0.6 -0.0 -0.1
Gout (self-reported) 0.2 0.3 1.2 -0.6 -0.4 -0.3 -0.1 -0.1 -0.3 0.4 1.1 0.5
Hypothyroidism/myxoedema (self-reported) 3.5 6.9 9.8 0.9 2.7 2.9 2.6 3.1 3.1 -3.1 0.7 3.1
Medication: Amlodipine 1.2 1.6 3.0 0.8 1.3 1.3 1.2 1.6 1.2 -1.7 -1.2 0.9
Medication: Ventolin 100micrograms inhaler 0.6 0.8 1.3 -0.3 -1.1 -1.0 -1.1 -0.9 -1.1 1.0 -0.6 -0.8
Birth weight 0.8 1.7 9.9 -3.1 -0.0 0.6 0.8 0.1 0.7 -0.6 1.8 0.8
Chronic bronchitis/emphysema (mother) 0.5 0.6 1.4 1.2 -0.0 -0.6 -0.7 -0.7 -0.5 0.5 -0.9 -1.2
High blood pressure (siblings) 1.1 1.6 2.6 -0.7 -0.9 -1.4 -1.4 -1.0 -1.4 1.2 -1.6 -1.4
Forced vital capacity (FVC), Best measure 2.3 8.5 13.1 0.6 2.7 3.4 3.6 2.4 3.5 -3.0 2.7 3.2
Body fat percentage 0.2 0.7 2.8 1.7 -0.7 -0.7 -0.8 0.1 -0.8 0.7 -0.9 -0.6
Leg fat percentage (right) 0.3 0.9 4.5 2.1 -0.8 -0.6 -0.7 -0.1 -0.6 0.7 -0.8 -0.9
Arm fat-free mass (right) 0.4 1.8 3.1 0.5 0.7 1.6 1.3 1.4 1.5 -1.5 1.7 1.3
Exposure to tobacco smoke outside home 0.5 0.6 2.1 -0.1 0.9 0.7 0.9 0.1 0.8 -0.4 1.4 0.8
Comparative body size at age 10 1.3 3.5 8.6 0.6 2.0 1.8 1.7 2.9 1.8 -2.3 -0.8 1.7
Number of full brothers 2.1 2.6 5.6 -0.3 1.9 1.5 1.5 2.4 1.5 -1.7 1.0 1.7
Worry too long after embarrassment 0.5 0.8 1.8 1.3 -0.5 -0.7 -0.6 -1.1 -0.8 0.9 0.1 -1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 3.6 1.9 0.6 0.2 0.3 -0.2 0.2 0.1 -0.0 -0.1
Wheeze or whistling in the chest in last year 0.8 1.5 7.3 0.4 -0.9 -1.0 -1.0 -0.3 -0.9 0.6 -2.7 -1.4
Number of children fathered 1.2 1.4 2.6 -1.6 -1.2 -1.0 -1.2 -1.5 -1.2 0.7 -0.8 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 1.7 0.4 0.7 1.1 1.2 0.7 1.1 -0.8 1.2 1.3
Age at first live birth 0.3 0.6 1.2 1.0 1.0 0.8 0.8 0.4 0.6 -1.1 0.1 0.8
Pulse wave peak to peak time 2.4 2.8 4.9 -0.2 1.5 1.8 1.7 1.6 1.8 -1.6 2.2 1.9
Health satisfaction 1.1 1.4 3.6 1.2 -0.9 -1.2 -1.1 -0.5 -1.1 1.3 -1.3 -1.9
Shortness of breath walking on level ground 0.3 0.3 2.1 -0.4 0.1 -0.3 -0.2 0.3 -0.2 0.1 -1.5 -0.4
Qualifications: College or University degree 0.3 1.0 4.8 -1.7 0.0 0.3 0.4 -0.5 0.3 -0.1 2.2 0.6
Eye problems/disorders: None of the above 0.2 0.2 1.1 -1.0 0.1 0.3 0.4 0.7 0.2 -0.4 -0.1 0.1
Mouth/teeth dental problems: Loose teeth 0.4 0.5 2.2 1.4 -0.1 -0.2 -0.2 0.1 -0.2 0.0 -1.5 -0.7
Emphysema/chronic bronchitis 0.1 0.1 0.5 0.7 -0.1 0.1 0.3 0.0 0.2 -0.2 -0.4 -0.4
Medication for pain relief, constipation, heartburn 0.8 1.4 5.9 -2.3 -0.1 0.7 0.4 0.2 0.6 -0.3 2.4 0.8
Neck or shoulder pain in last month 0.0 0.1 0.2 0.5 0.2 0.2 0.3 0.3 0.1 0.0 -0.1 -0.1
Medication: Blood pressure 0.4 0.8 4.5 2.1 0.0 -0.2 -0.2 0.5 -0.0 -0.0 -1.0 -1.0
Angina (self-reported) 0.9 1.2 2.1 0.6 1.1 1.1 1.1 1.3 1.0 -1.5 -0.9 1.0
Migraine (self-reported) 0.1 0.1 0.4 -0.1 0.6 0.2 0.5 0.4 0.3 -0.0 -0.4 0.3
Medication: Ibuprofen 0.6 0.7 2.9 0.8 -0.3 -0.8 -0.6 -0.3 -0.7 0.5 -1.7 -1.0
Medication: Allopurinol 0.1 0.2 1.1 0.1 0.0 0.1 0.2 0.1 -0.0 0.1 1.1 0.6
Medication: Omeprazole 0.7 0.8 1.8 0.7 -0.4 -1.0 -0.8 -0.2 -0.9 0.9 -1.4 -1.2
Medication: Seretide 50 evohaler 1.4 1.6 2.9 1.5 1.7 1.3 1.4 1.1 1.4 -1.3 0.1 0.8
Mean time to correctly identify matches 0.6 1.2 5.6 2.4 0.9 0.9 1.0 0.3 0.9 -1.0 -0.4 0.9
Heart disease (mother) 0.9 1.1 4.7 0.6 -1.1 -0.9 -0.9 -0.3 -1.0 0.2 -2.2 -1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 2.4 -1.5 -1.0 -1.2 -0.9 -0.8 -1.3 1.1 -0.3 -0.8
Whole body fat mass 0.1 0.3 2.1 1.5 -0.4 -0.0 -0.2 0.4 -0.1 0.2 0.1 -0.0
Leg fat mass (right) 0.1 0.4 1.8 1.4 -0.7 -0.3 -0.4 0.1 -0.4 0.4 -0.0 -0.4
Arm predicted mass (right) 0.4 2.0 3.6 0.4 0.7 1.7 1.3 1.5 1.6 -1.6 1.9 1.3
Pulse rate, automated reading 0.2 0.5 2.2 1.5 0.4 -0.3 -0.2 -0.9 -0.2 0.4 -0.9 -0.4
Alcohol intake frequency. 1.4 3.3 5.5 -0.2 -1.7 -2.1 -1.8 -1.8 -1.9 2.3 -1.4 -2.1
Comparative height size at age 10 0.1 0.8 3.5 -1.9 0.1 0.7 0.7 0.4 0.6 -0.8 0.8 0.8
Number of full sisters 5.4 6.6 9.8 1.2 2.7 2.9 2.8 2.9 2.8 -3.1 0.3 3.0
Suffer from ‘nerves’ 0.1 0.1 0.6 0.8 0.1 0.4 0.3 0.4 0.4 -0.4 -0.1 0.2
Overall health rating 0.9 1.9 5.1 2.3 1.6 0.7 0.8 1.4 0.6 -0.9 -2.2 0.7
Chest pain or discomfort 0.6 0.8 1.4 0.7 1.2 1.0 0.9 1.0 0.9 -1.1 -0.3 0.8
Had major operations 0.7 0.9 2.0 -1.4 0.4 0.8 0.7 0.9 0.7 -1.0 0.5 1.4
Age at last live birth 0.6 0.9 1.8 0.1 -0.5 -1.1 -1.1 -0.9 -1.2 0.8 -0.6 -1.3
Family relationship satisfaction 0.8 1.0 2.8 1.7 0.9 0.7 0.7 0.6 0.8 -0.2 1.6 0.6
Leg pain on walking 0.1 0.1 0.4 0.6 0.3 -0.2 0.0 -0.1 -0.0 0.2 -0.5 -0.3
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 2.0 0.6 0.6 0.9 0.7 0.8 1.0 -0.8 1.4 0.5
Commuting to job workplace: Car/motor vehicle 0.9 1.0 3.4 0.9 1.8 0.7 1.0 1.0 0.8 -0.9 -0.8 0.7
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 2.8 0.1 -1.3 -1.1 -0.8 -1.7 -1.1 1.1 -0.4 -1.0
Medication: Aspirin 0.8 1.1 3.2 1.8 1.0 0.8 0.6 0.7 0.8 -1.3 -1.0 0.9
Supplements: Vitamin C 0.2 0.3 0.9 -0.9 0.2 0.4 0.4 -0.4 0.3 -0.3 1.0 0.2
Knee pain experienced in last month 1.5 2.3 3.3 -1.6 -1.7 -1.6 -1.4 -1.8 -1.5 1.8 0.2 -1.3
Hypertension (Self-reported) 1.1 3.2 10.6 3.2 2.0 1.4 1.5 1.6 1.5 -1.8 -1.1 0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 6.0 7.0 9.8 -1.3 -2.9 -3.1 -3.1 -2.1 -3.1 3.1 -1.3 -2.9
Illnesses of father: Heart disease 0.8 1.1 2.4 0.7 1.5 1.2 1.2 0.8 1.1 -1.3 -0.2 1.0
Illnesses of siblings: Diabetes 2.1 2.6 3.6 1.7 1.5 1.7 1.9 1.9 1.8 -1.7 -0.2 1.4
Smoking status: Previous 1.2 1.9 3.1 -0.8 -0.6 -1.5 -1.7 -1.3 -1.4 1.2 -1.6 -1.8
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.1 0.5 0.7 -0.4 -0.1 -0.1 -0.2 -0.1 0.4 0.5 -0.4
Whole body fat-free mass 0.3 1.7 4.6 0.3 0.4 1.5 1.2 1.2 1.4 -1.3 2.1 1.3
Leg fat-free mass (right) 0.4 2.3 3.8 0.7 0.7 1.8 1.5 1.4 1.6 -1.6 2.0 1.7
Arm fat percentage (left) 0.2 0.8 5.7 2.4 -0.3 -0.0 -0.2 0.6 -0.2 0.1 -0.8 -0.0
Average weekly red wine intake 0.3 0.5 1.4 -1.2 -0.7 -0.5 -0.4 -0.9 -0.5 0.4 0.5 -0.5
Handedness (chirality/laterality): Left-handed 0.9 1.1 4.0 1.7 1.2 0.2 0.5 1.0 0.4 -0.7 -2.0 -0.2
Mood swings 0.3 0.5 1.4 1.2 -0.1 -0.5 -0.4 -0.8 -0.5 0.5 -0.9 -0.9
Loneliness, isolation 1.7 2.4 4.2 2.1 1.3 1.7 1.9 1.0 1.6 -1.3 1.1 1.6
Long-standing illness, disability or infirmity 0.4 0.6 0.9 0.0 -0.8 -0.9 -1.0 -0.8 -0.9 0.8 -0.9 -0.5
Ever had bowel cancer screening 1.1 1.3 7.1 -2.7 -1.0 -0.9 -0.8 -0.4 -0.9 0.8 -0.3 -0.6
Diabetes diagnosed by doctor 0.8 1.3 6.9 2.6 1.0 0.6 0.5 1.0 0.6 -0.8 -1.2 0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.6 -0.5 -0.4 -0.5 -0.8 -0.8 -0.6 0.4 -0.3 0.1
Friendships satisfaction 2.4 3.0 5.8 0.7 1.2 1.9 1.9 1.6 1.9 -1.4 2.4 1.9
Qualifications: nursing, teaching 0.4 0.7 1.6 -0.9 -0.9 -0.9 -1.3 -0.5 -0.9 0.7 -0.2 -0.6
Commuting to job workplace: Walk 0.9 1.0 2.0 -0.9 -1.2 -0.9 -1.2 -1.4 -0.9 1.0 0.2 -1.0
Eye problems/disorders: Cataract 0.3 0.4 2.5 0.0 -0.0 0.0 0.2 -0.6 0.1 0.4 1.6 0.5
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 1.0 -1.0 -0.2 -0.2 -0.3 0.7 -0.3 -0.2 -0.8 -0.0
Medication for cholesterol 0.0 0.1 0.4 -0.3 -0.1 0.1 0.1 0.0 0.1 0.3 0.7 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 1.9 -1.4 -0.5 -0.8 -0.9 -1.1 -0.8 0.8 -0.5 -0.5
Back pain experienced in last month 3.1 4.6 6.3 -2.5 -2.3 -2.2 -1.9 -2.4 -2.3 2.4 0.1 -2.1
Mineral and other dietary supplements 0.2 0.2 1.4 -0.0 -0.5 0.1 -0.0 0.5 0.0 0.4 1.2 0.3
Breast cancer (self-reported) 0.4 0.5 1.1 -0.7 -0.7 -0.8 -0.7 -1.0 -0.7 0.9 0.2 -0.5
Asthma (self-reported) 0.8 1.7 2.6 0.7 1.4 1.5 1.6 1.2 1.6 -1.6 -0.1 1.2
Osteoporosis (self-reported) 0.9 1.1 1.8 -1.3 -1.3 -1.1 -1.2 -1.3 -1.1 0.9 0.5 -0.6
Osteoarthritis (self-reported) 3.0 3.9 7.8 -2.8 -2.1 -2.0 -1.9 -2.4 -1.9 2.0 0.1 -1.5
Medication: Aspirin 0.6 0.8 3.6 1.9 0.8 0.5 0.3 0.3 0.5 -0.9 -0.9 0.7
Medication: Gliclazide 4.9 5.5 7.8 2.1 2.4 2.6 2.6 2.4 2.8 -2.5 0.8 2.2
Illnesses of father: None of the above (group 1) 0.5 0.6 0.7 -0.6 -0.7 -0.8 -0.8 -0.8 -0.8 0.8 0.8 -0.6
Smoking status: Current 0.5 0.7 1.2 -0.9 -1.0 -0.8 -0.7 -1.0 -0.8 1.1 0.4 -0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 4.0 8.4 12.1 0.8 3.2 3.3 3.3 2.9 3.5 -3.2 1.0 3.4
Whole body water mass 0.3 1.8 4.0 0.3 0.6 1.6 1.3 1.3 1.5 -1.4 2.0 1.3
Leg predicted mass (right) 0.5 2.5 3.9 0.7 0.8 1.8 1.6 1.5 1.7 -1.7 2.0 1.8
Arm fat mass (left) 0.1 0.4 3.2 1.8 -0.2 0.3 -0.0 0.7 0.1 -0.2 -0.2 0.2
Number of self-reported non-cancer illnesses 0.5 0.8 3.3 1.8 0.4 -0.1 -0.2 0.8 -0.1 -0.4 -1.8 -0.0
Average weekly champagne plus white wine intake 1.3 1.8 3.0 0.7 1.4 1.6 1.4 1.2 1.7 -1.7 0.3 1.4
Miserableness 0.2 0.3 0.8 0.9 0.6 0.5 0.5 0.5 0.4 -0.6 -0.1 0.3
Guilty feelings 0.7 1.0 4.6 1.4 0.3 -0.4 -0.5 -0.0 -0.5 0.1 -2.2 -1.2
Wears glasses or contact lenses 0.9 1.0 2.6 -1.6 -0.7 -1.0 -1.0 -1.1 -0.9 0.7 -0.7 -0.8
Ever taken oral contraceptive pill 2.8 3.1 4.2 2.0 1.7 2.0 1.9 1.2 2.0 -2.0 0.4 1.9
Hearing aid user 0.4 0.5 1.5 -1.2 0.3 0.5 0.3 0.3 0.3 -0.4 1.2 0.7
Mother’s age at death 0.6 0.7 1.4 0.9 1.2 0.7 0.8 1.0 0.6 -0.8 -0.5 0.7
Financial situation satisfaction 0.4 0.4 0.9 0.4 0.9 0.6 0.4 0.9 0.6 -0.7 0.0 0.8
Tinnitus: Yes, now most or all of the time 0.3 0.4 1.7 -1.3 -0.5 -0.1 0.3 -0.5 0.0 0.3 0.8 -0.3
Commuting to job workplace: Public transport 0.4 0.5 1.1 0.2 -1.1 -0.6 -0.8 -0.8 -0.6 0.7 0.2 -0.6
Eye problems/disorders: Glaucoma 0.6 0.7 1.5 -0.6 -0.8 -0.9 -0.8 -1.0 -0.8 1.2 -0.3 -0.6
Medication: Blood pressure 0.2 0.3 1.5 1.2 0.1 -0.0 0.1 -0.1 -0.1 -0.1 -1.1 -0.3
Pain type(s) experienced in last month: Hip pain 0.7 0.9 6.8 -0.2 0.3 -0.5 -0.2 0.2 -0.5 0.0 -2.6 -0.5
Supplements: Fish oil (including cod liver oil) 0.2 0.3 1.2 1.1 0.6 0.3 0.4 -0.2 0.2 -0.6 -0.8 0.3
High cholesterol (Self-reported) 0.2 0.3 1.7 0.4 -0.4 -0.3 -0.3 -0.3 -0.2 -0.2 -1.3 -0.2
Medication: Bendroflumethiazide 1.9 3.0 5.3 0.0 -1.6 -1.9 -1.9 -1.2 -1.9 1.4 -2.3 -2.2
Medication: Paracetamol 1.3 2.0 7.3 1.6 -0.2 -1.2 -1.1 -1.2 -1.3 0.9 -2.7 -1.3
Medication: Lisinopril 0.1 0.1 0.4 0.4 0.0 -0.0 0.0 -0.4 0.1 0.1 -0.3 -0.7
Medication: Atorvastatin 1.4 1.7 2.7 -0.0 1.6 1.5 1.3 1.6 1.6 -1.5 0.3 1.3
Illnesses of father: High blood pressure 5.6 7.0 10.0 1.7 2.7 3.2 2.8 2.4 3.0 -3.0 1.3 3.1
Alcohol drinker status: Never 0.2 0.2 1.2 1.1 0.4 0.3 0.4 0.3 0.5 -0.2 -0.2 0.5
Ever smoked 0.8 1.5 2.8 -1.7 -1.1 -1.2 -1.1 -1.7 -1.2 1.1 0.0 -1.1
Basal metabolic rate 0.3 1.6 3.7 0.7 0.4 1.5 1.2 1.2 1.4 -1.3 1.9 1.2
Leg fat percentage (left) 0.3 0.9 3.5 1.9 -0.9 -0.7 -0.8 -0.1 -0.7 0.8 -1.0 -0.9
Arm fat-free mass (left) 0.2 0.8 1.8 0.5 0.3 1.1 0.8 0.9 1.1 -0.9 1.4 0.7
Number of operations (self-reported) 0.3 0.5 1.6 -1.3 -0.8 -0.4 -0.4 -0.0 -0.6 -0.0 -1.1 0.2
Average weekly beer plus cider intake 0.3 0.5 1.4 -0.3 0.9 0.5 0.7 1.2 0.5 -0.7 -0.1 0.9
Irritability 1.1 1.9 3.4 -0.3 -1.2 -1.6 -1.5 -1.7 -1.5 1.3 -0.7 -1.9
Risk taking 0.8 1.2 2.6 -1.4 -0.7 -0.9 -0.9 -1.6 -0.8 1.0 1.0 -1.0
Ever had prostate specific antigen (PSA) test 2.0 2.3 7.3 -2.7 -1.6 -1.3 -1.3 -1.3 -1.4 1.5 -0.0 -1.1
Fractured/broken bones in last 5 years 0.3 0.3 1.0 -0.1 1.0 0.4 0.2 0.9 0.2 -0.5 -0.8 0.2
Age started oral contraceptive pill 0.2 0.2 0.8 0.9 0.3 0.3 0.3 0.3 0.4 -0.2 0.5 0.2
Diastolic blood pressure, automated reading 0.2 0.7 4.8 2.2 -0.2 -0.3 -0.6 -0.5 -0.4 0.6 0.2 -0.7
Ever depressed for a whole week 0.6 0.8 1.4 0.7 1.2 0.9 0.9 1.0 1.0 -1.0 -0.0 0.7
Unable to work because of sickness or disability 0.9 1.1 3.5 0.3 1.4 0.8 0.7 0.8 0.6 -1.1 -1.9 1.0
Commuting to job workplace: Cycle 2.1 2.5 5.8 -1.5 0.7 1.7 1.5 1.3 1.6 -1.3 2.4 1.8
Myopia 0.4 0.6 1.7 -0.4 1.2 0.5 0.5 0.9 0.4 -0.8 -1.3 0.7
Vascular/heart problems diagnosed by doctor 0.9 2.4 10.0 -3.2 -1.6 -1.0 -1.0 -1.2 -1.1 1.4 1.5 -0.3
Cholesterol lowering medication 0.1 0.2 0.5 -0.2 -0.5 -0.3 -0.5 -0.7 -0.4 0.3 -0.5 -0.3
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 1.8 0.6 -0.6 -1.1 -0.8 -0.3 -0.9 0.9 -1.4 -1.2
Pain experienced in last month 2.3 3.8 5.9 0.7 1.6 2.3 2.0 1.5 2.3 -2.2 1.7 2.4
Supplements: Calcium 0.7 0.8 1.4 -1.2 -0.7 -0.9 -0.9 -0.9 -1.0 0.8 -0.3 -0.8
Basal cell carcinoma (self-reported) 0.2 0.2 0.4 0.3 0.4 0.5 0.6 0.1 0.4 -0.2 0.7 0.6
Heart attack/myocardial infarction (self-reported) 1.1 1.4 6.6 1.5 1.0 0.2 0.4 1.2 0.3 -0.8 -2.6 -0.4
Deep venous thrombosis (DVT) (self-reported) 0.8 1.1 6.2 2.5 0.8 0.5 0.5 1.2 0.6 -0.6 -0.5 0.1
Heart disease (siblings) 2.1 2.6 3.4 -1.1 -1.8 -1.8 -1.4 -1.5 -1.8 1.5 -1.6 -1.8
Alcohol drinker status: Previous 1.7 1.9 3.6 -0.4 -0.8 -1.6 -1.7 -0.9 -1.5 1.3 -1.9 -1.6
Pack years of smoking 0.3 0.5 1.3 -1.2 -0.8 -0.6 -0.2 -0.5 -0.4 0.7 0.9 -0.3
Impedance of whole body 0.6 3.0 4.6 -1.6 -1.6 -1.9 -1.5 -2.1 -1.9 2.1 -0.0 -1.6
Leg fat mass (left) 0.1 0.4 1.6 1.3 -0.8 -0.4 -0.5 0.0 -0.4 0.5 -0.1 -0.5
Arm predicted mass (left) 0.2 1.0 1.6 0.3 0.4 1.2 0.8 1.2 1.2 -1.1 1.3 0.8