Hub : Genes

ADSSL1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0540	0.0210	4.3e-03	0.010	0.014	0.010	0.015	0.012	2.1e-02	6.7e-03	1.9e-02	0.0055	1.1e-02
2	GTEx	Cells Transformed fibroblasts	0.1250	0.0420	4.7e-04	0.047	NA	0.050	NA	0.047	2.0e-04	NA	1.2e-04	NA	1.8e-04
3	GTEx	Esophagus Mucosa	0.2710	0.0520	1.6e-10	0.218	NA	0.188	NA	0.208	1.3e-14	NA	1.2e-12	NA	6.0e-14
4	GTEx	Esophagus Muscularis	0.1420	0.0500	1.5e-03	0.102	NA	0.076	NA	0.093	9.3e-07	NA	2.4e-05	NA	3.0e-06
5	GTEx	Skin Not Sun Exposed Suprapubic	0.3160	0.0620	1.2e-08	0.155	NA	0.205	NA	0.202	7.7e-09	NA	1.8e-11	NA	2.7e-11
6	GTEx	Skin Sun Exposed Lower leg	0.2350	0.0500	3.6e-10	0.217	NA	0.175	NA	0.096	7.2e-18	NA	2.0e-14	NA	2.6e-08
7	GTEx	Testis	0.5110	0.0570	0.0e+00	0.557	NA	0.594	NA	0.575	2.9e-29	NA	3.5e-32	NA	1.3e-30
8	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1360	0.0690	6.2e-03	0.018	-0.004	-0.003	NA	0.022	3.1e-02	7.0e-01	5.1e-01	NA	1.9e-02
9	TCGA	Prostate Adenocarcinoma	0.0571	0.0268	3.7e-05	0.054	0.040	0.024	NA	0.044	2.5e-06	4.2e-05	1.3e-03	NA	1.9e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Bipolar Disorder (2018)	0.8	1.3	3.9	0.0	-2.0	-1.1	-1.1	-1.4	-1.1	1.6	0.0	0.0
Bipolar Disorder or Schizophrenia	1.1	2.6	5.1	-1.9	-2.3	-1.5	-1.5	-2.0	-1.7	2.0	0.0	0.0
Depressed Affect (Nagel 2018)	0.2	0.4	1.4	1.1	0.4	-0.2	-0.1	0.4	-0.1	0.1	-1.2	-0.6
Depression (Nagel 2018)	0.7	1.1	2.3	1.5	1.5	0.8	0.7	1.3	0.8	-0.9	-0.8	0.5
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.3	0.8	0.6	0.2	0.2	1.2	0.1	-0.7	-1.0	0.6
Neuroticism (Nagel 2018)	0.2	0.5	2.2	1.5	0.2	-0.3	-0.2	0.1	-0.3	0.3	-1.0	-0.9
Schizophrenia (2018)	0.7	1.4	3.6	-1.9	-1.3	-1.0	-1.1	-1.4	-1.3	1.3	0.0	0.0
Schizophrenia vs Biploar Disorder	0.1	0.1	0.6	-0.8	-0.1	-0.2	0.1	0.0	-0.2	0.2	0.0	0.0
Worry (Nagel 2018)	0.2	0.5	1.4	0.5	-0.2	-0.7	-0.6	-0.3	-0.7	0.6	-1.2	-1.0
Alzheimer’s Disease (in mother)	0.2	0.2	0.4	-0.3	-0.3	-0.5	-0.5	-0.0	-0.5	0.7	0.5	-0.3
Alzheimer’s Disease (in father)	0.1	0.1	0.7	-0.2	-0.1	-0.1	-0.3	0.2	-0.1	0.0	-0.9	-0.1
Alzheimer’s Disease (including proxy)	0.7	1.1	1.8	0.1	-0.9	-1.3	-1.3	-0.5	-1.2	1.3	-0.8	-1.2
Crohns Disease (2017)	0.1	0.3	1.0	1.0	0.4	0.2	0.0	0.2	0.2	-0.6	-0.9	0.1
Irritable Bowel Disease (IBD)	0.3	0.8	1.6	0.3	-1.1	-0.9	-0.9	-1.3	-0.9	0.7	-0.6	-0.7
Ulcerative Colitis (UC)	1.6	3.1	5.6	-0.5	-2.4	-1.8	-1.7	-2.3	-2.0	1.9	-0.6	-1.5
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	2.4	4.5	10.7	3.3	1.8	2.2	2.1	1.6	2.1	-2.4	0.1	2.0
Verbal and Numeric Reasoning (VNR)	0.4	1.0	1.8	-0.7	-0.9	-1.3	-1.3	-0.4	-1.4	1.0	-0.8	-0.7
Breast Cancer	9.6	23.1	30.6	3.5	5.3	5.2	5.5	5.3	5.4	-4.9	1.8	5.1
Ovarian Cancer	1.5	2.0	3.1	0.5	1.6	1.6	1.5	0.7	1.8	-1.4	1.3	1.7
Prostate Cancer	2.0	2.9	5.5	-0.1	-1.0	-1.9	-1.7	-1.6	-1.9	1.6	-2.3	-2.0
Age at First Birth	1.6	2.4	4.0	-1.4	-1.7	-1.8	-2.0	-1.5	-1.9	1.8	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.3	0.4	1.8	-1.4	-0.1	0.3	0.2	1.1	0.3	-0.3	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.3	0.5	1.7	0.1	0.8	0.5	0.4	1.3	0.6	-1.0	0.0	0.0
Mean Putamen Volume	2.5	2.9	7.9	0.0	-1.3	-1.8	-1.7	-0.9	-1.8	1.3	-2.8	-2.0
Fasting Glucose	0.2	0.3	1.4	0.3	-0.1	-0.5	-0.3	-1.2	-0.4	0.7	0.0	0.0
HbA1C	2.1	2.3	3.9	1.0	1.7	1.8	1.7	2.0	1.7	-2.0	0.0	0.0
HDL Cholesterol	1.2	2.0	7.0	-2.6	-1.7	-1.3	-1.2	-1.0	-1.3	1.4	0.0	0.0
LDL Cholesterol	0.4	0.6	0.9	0.6	-0.9	-1.0	-0.9	-0.6	-0.9	1.0	0.0	0.0
Lupus	0.1	0.2	0.5	-0.1	0.4	0.3	0.5	0.6	0.4	-0.3	0.4	0.7
Neuroticism (2016)	0.8	1.2	2.0	1.2	-1.3	-1.0	-0.9	-0.7	-1.3	0.8	-1.0	-1.4
Primary Biliary Cirrhosis	1.8	2.6	5.6	-2.4	-2.1	-1.4	-1.4	-1.4	-1.5	1.8	0.7	-1.3
Rheumatoid Arthritis	0.6	0.8	1.8	0.6	-0.4	-1.2	-0.9	-1.1	-1.1	1.3	0.0	0.0
Schizophrenia (2014)	0.6	1.3	2.7	-1.6	-1.4	-1.0	-1.1	-1.1	-1.1	1.3	0.0	0.0
Triglycerides	1.0	1.7	3.9	1.1	1.7	1.2	1.4	2.0	1.2	-1.5	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	2.0	2.8	5.4	-1.8	-2.3	-1.6	-1.7	-1.9	-1.8	2.0	0.0	0.0
Blood Eosinophil Count	0.1	1.0	2.4	0.9	0.8	1.1	0.9	0.5	1.2	-0.8	1.6	1.1
Blood Platelet Count	0.5	5.3	20.5	4.5	3.0	1.8	1.3	1.8	1.9	-1.7	-0.4	1.9
Blood Red Count	0.8	7.9	21.3	-4.6	-3.1	-2.3	-2.5	-3.1	-2.4	2.8	1.3	-1.9
Blood White Count	1.8	13.6	36.0	6.0	3.8	3.5	3.1	3.8	3.4	-3.4	0.1	3.4
Heel T-Score	0.1	0.6	1.7	1.0	-0.3	-0.6	-0.9	-1.3	-0.6	0.8	-0.7	-0.4
BMI	0.4	2.3	5.3	2.3	0.9	1.6	1.1	1.8	1.4	-1.3	1.1	1.7
Height	0.0	0.9	2.8	-1.7	-1.1	-0.7	-0.8	-0.6	-0.8	0.9	0.8	-0.6
Waist Hip Ratio (WHR)	0.3	1.4	3.6	1.9	1.0	1.1	1.2	0.7	1.2	-0.8	1.3	1.1
Systolic Blood Pressure	0.3	1.6	10.6	3.3	0.9	0.5	0.5	0.6	0.4	-0.6	-1.0	0.1
Smoking Status	0.3	0.8	1.2	-1.1	-0.7	-0.9	-1.0	-0.9	-0.9	0.9	-0.5	-1.1
Allergy or Eczema	0.3	0.9	5.4	-2.3	-0.5	0.2	0.3	0.8	0.2	-0.4	1.1	0.6
Cardiovascular Disease	1.2	4.0	5.9	2.4	2.3	2.1	2.0	1.9	2.0	-2.2	0.1	1.9
Hypothyroidism (self reported)	3.4	7.8	11.6	0.7	2.6	3.2	2.8	3.2	3.2	-3.2	1.5	3.4
Respiratory disease	0.9	2.0	3.1	-0.1	1.4	1.7	1.6	1.4	1.7	-1.8	0.6	1.6
Type 2 Diabetes (T2D) (2018)	2.5	4.8	12.9	3.6	2.4	2.0	1.7	2.5	1.9	-2.0	-0.7	1.8
Lung FEV1/FVC ratio	2.3	11.4	14.3	3.7	3.7	3.8	3.4	3.0	3.6	-3.6	1.7	3.4
Lung FVC	2.1	10.8	16.5	-0.6	3.2	3.7	4.1	2.7	4.0	-3.6	2.6	3.7
Neuroticism	0.4	1.1	2.0	0.7	-0.5	-1.1	-1.3	-0.6	-1.2	1.0	-1.4	-1.3
Chronotype (morning person)	2.4	5.5	7.6	-0.8	2.2	2.7	2.5	2.7	2.7	-2.6	1.2	2.8
Hair Pigment	0.1	2.4	4.1	-0.7	1.6	1.7	1.5	1.8	1.6	-2.0	0.2	1.9
Tanning	0.1	1.2	6.1	-2.5	-0.9	-0.8	-0.9	-0.3	-0.8	1.0	0.7	-0.6
Hand grip strength (left)	0.7	1.8	6.7	-2.3	-0.2	0.7	0.7	-0.0	0.7	-0.4	2.6	1.4
Number of treatments/medications taken	1.1	1.9	10.6	2.2	-0.1	-0.6	-0.7	0.2	-0.6	-0.0	-3.2	-0.9
Average weekly spirits intake	1.8	2.3	5.0	0.3	1.3	1.7	1.8	1.2	1.5	-1.9	0.3	2.2
Sensitivity / hurt feelings	0.6	1.0	2.0	-0.1	1.0	1.2	1.0	0.8	1.1	-0.9	1.4	0.9
Frequency of depressed mood in last 2 weeks	0.9	1.2	4.1	2.0	1.1	0.9	0.7	1.2	0.6	-1.1	-0.9	0.7
Hearing difficulty/problems: Yes	0.7	1.1	1.4	-1.1	0.8	1.1	1.1	1.2	1.1	-0.9	1.1	1.0
Relative age of first facial hair	1.4	2.9	6.9	-1.4	1.1	1.6	1.8	1.0	1.7	-1.0	2.6	2.2
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	3.5	0.7	0.5	0.2	-0.2	0.8	0.1	-0.8	-1.9	0.8
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.4	-0.5	-0.6	-0.6	-0.2	-0.5	-0.4	0.3	-0.5	-0.6
Ever had hysterectomy (womb removed)	2.6	3.0	4.4	-0.3	-1.6	-2.0	-1.8	-1.8	-1.9	2.1	-1.3	-2.1
Systolic blood pressure, automated reading	0.4	1.3	7.9	2.8	-0.2	-0.6	-0.6	-0.4	-0.6	0.6	-1.1	-0.9
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	6.5	2.5	1.3	1.2	1.1	0.9	1.0	-1.2	-0.1	0.9
Angina	1.1	1.4	2.6	0.8	1.2	1.2	1.2	1.5	1.1	-1.6	-1.0	0.9
Medication for hormone replacement therapy	0.2	0.3	0.5	-0.6	-0.4	-0.6	-0.5	-0.4	-0.6	0.4	-0.1	-0.7
Vitamin and mineral supplements	0.4	0.6	2.0	-0.9	-1.1	-0.4	-0.4	-0.3	-0.3	0.9	1.4	-0.2
Supplements: Zinc	0.4	0.4	0.8	0.1	-0.7	-0.7	-0.6	-0.3	-0.8	0.3	-0.9	-0.8
Medication: Co-codamol	1.1	1.2	4.1	1.2	0.8	0.7	0.7	1.4	0.8	-0.8	-2.0	0.8
Medication: Metformin	1.9	2.7	9.0	3.0	1.2	1.4	1.3	1.8	1.4	-1.7	-0.8	1.0
Diabetes (father)	0.7	0.9	2.7	1.5	0.5	0.6	0.3	1.0	0.4	-1.1	-1.6	0.6
Diabetes (mother)	2.5	3.2	7.2	2.2	2.7	1.5	1.2	1.6	1.4	-1.9	-1.7	1.5
Severe depression (siblings)	0.2	0.3	1.6	-1.3	-0.1	0.1	0.0	-0.4	0.1	0.4	0.8	0.2
Pack years adult smoking proportion	0.3	0.4	0.9	-0.8	-0.7	-0.6	-0.2	-0.6	-0.5	0.7	0.9	-0.4
Impedance of leg (right)	0.3	1.5	2.6	-1.1	-1.0	-1.3	-1.1	-1.4	-1.3	1.6	0.3	-1.3
Leg fat-free mass (left)	0.5	2.6	3.9	1.0	0.9	1.9	1.6	1.6	1.8	-1.7	2.0	1.8
Trunk fat percentage	0.1	0.6	2.1	1.5	-0.7	-0.6	-0.7	0.0	-0.7	0.7	-0.7	-0.5
Hand grip strength (right)	1.2	3.3	7.6	-2.8	0.6	1.6	1.6	0.8	1.6	-1.4	2.4	2.5
Townsend deprivation index at recruitment	0.3	0.5	1.0	-0.3	0.6	0.5	0.6	0.7	0.6	-0.5	1.0	1.0
Current tobacco smoking	0.2	0.3	0.7	-0.6	-0.6	-0.4	-0.3	-0.9	-0.4	0.7	0.4	-0.4
Average weekly fortified wine intake	0.2	0.2	1.2	0.6	1.1	-0.0	-0.1	-0.5	-0.0	0.1	-0.4	0.2
Maternal smoking around birth	0.1	0.1	0.3	-0.2	0.3	0.3	0.4	0.0	0.5	-0.5	-0.1	0.2
Fed-up feelings	0.6	1.0	6.0	1.3	0.6	-0.4	-0.4	0.1	-0.3	-0.1	-2.5	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.3	3.5	1.9	1.2	1.0	0.8	0.9	0.9	-1.2	-0.6	1.2
Relative age voice broke	0.8	1.1	4.2	-1.7	0.5	0.6	0.8	-0.0	0.7	-0.1	2.1	1.2
Taking other prescription medications	0.5	0.8	3.7	1.5	0.1	0.0	-0.4	0.9	-0.1	-0.3	-1.9	0.2
Age when periods started (menarche)	0.2	0.6	1.5	0.3	-0.5	-0.8	-0.6	-0.6	-0.7	1.0	1.2	-0.6
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.6	0.8	0.2	0.5	0.7	0.3	0.5	-0.3	-0.0	0.2
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.9	3.9	2.0	2.0	1.8	1.6	1.4	1.8	-1.5	0.8	2.0
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.7	-0.8	-0.5	0.2	0.2	0.1	0.3	0.1	1.3	-0.0
Qualifications: CSEs or equivalent	1.3	1.7	2.9	1.1	1.4	1.4	1.3	1.7	1.2	-1.5	0.1	1.3
Serious illness, injury or assault to yourself	1.5	1.8	11.2	1.4	0.5	-0.8	-0.7	0.5	-0.7	-0.1	-3.4	-1.1
High blood pressure	1.1	2.9	11.0	3.3	1.8	1.3	1.4	1.5	1.4	-1.6	-1.1	0.6
Hayfever, allergic rhinitis or eczema	0.6	1.3	7.3	-2.7	-0.7	0.2	0.3	0.6	0.2	-0.1	1.9	0.5
Multivitamins +/- minerals	0.4	0.5	2.3	1.4	0.6	0.0	0.0	0.1	0.0	-0.4	-1.5	-0.2
Stomach or abdominal pain in last month	0.2	0.2	0.7	0.9	0.5	0.3	0.5	-0.3	0.4	-0.4	-0.3	-0.0
Supplements: Glucosamine	0.2	0.3	1.1	-1.0	-0.3	-0.0	0.2	-0.6	-0.0	-0.1	1.0	-0.1
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.9	0.0	-0.6	-0.4	-0.3	-0.8	-0.6	0.8	0.9	-0.5
Medication: Atenolol	0.5	0.7	1.3	0.5	-0.8	-0.7	-1.1	-0.2	-0.9	0.7	-1.1	-0.8
Medication: Levothyroxine sodium	2.9	4.9	7.4	0.5	2.3	2.4	2.2	2.5	2.5	-2.7	-0.1	2.7
Sitting height	0.3	1.9	10.2	-1.3	-0.1	1.0	1.1	-0.5	1.0	-0.6	3.2	1.0
Chronic bronchitis/emphysema (father)	0.8	1.0	1.9	-0.5	-1.4	-1.2	-1.1	-0.5	-0.9	1.0	-0.9	-1.1
High blood pressure (mother)	1.0	1.4	2.7	0.7	1.5	1.2	1.6	1.3	1.3	-1.3	-0.0	1.0
Body mass index (BMI)	0.2	1.0	5.4	2.3	0.4	0.7	0.4	1.3	0.6	-0.7	-0.5	0.5
Impedance of leg (left)	0.5	2.4	3.6	-1.6	-1.4	-1.7	-1.4	-1.7	-1.7	1.9	-0.1	-1.6
Leg predicted mass (left)	0.5	2.6	4.0	0.9	0.9	1.9	1.7	1.6	1.8	-1.7	2.0	1.8
Trunk fat mass	0.1	0.3	1.8	1.3	-0.7	-0.2	-0.4	0.2	-0.3	0.4	0.1	-0.2
Waist circumference	0.1	0.5	3.8	2.0	0.2	0.3	0.1	0.4	0.3	-0.1	0.3	0.1
Number of incorrect matches in round	0.3	0.5	2.9	-1.7	-0.2	0.1	0.2	-0.4	0.0	-0.1	1.0	0.4
Past tobacco smoking	1.6	3.0	4.4	1.4	1.1	1.9	2.0	1.8	1.9	-1.6	1.5	2.1
Alcohol usually taken with meals	0.6	0.9	1.9	1.2	0.9	1.0	0.7	1.2	1.0	-1.4	-0.1	0.4
Nervous feelings	1.3	2.3	3.7	1.9	1.7	1.7	1.6	1.3	1.7	-1.7	-0.3	1.3
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.4	6.6	2.6	1.7	1.2	1.1	1.8	1.2	-1.5	-1.2	0.8
Hearing difficulty/problems with background noise	0.1	0.2	0.8	-0.5	-0.2	-0.3	-0.9	-0.3	-0.5	0.5	0.1	0.0
Hair/balding pattern: Pattern 2	0.9	1.2	4.9	2.0	1.0	-0.1	-0.2	0.2	-0.0	-0.3	-2.2	-0.6
Had menopause	1.0	1.2	1.5	-1.0	-1.1	-1.2	-1.2	-1.2	-1.1	1.2	-0.5	-1.2
Had other major operations	0.4	0.5	1.2	-1.0	-0.6	-0.6	-0.7	-0.9	-0.6	0.4	-1.1	-0.1
Forced vital capacity (FVC)	2.0	7.8	11.2	-0.0	2.3	3.2	3.3	2.1	3.3	-2.8	3.3	3.1
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.5	5.9	2.4	2.2	2.0	1.8	1.4	2.0	-1.6	0.3	2.1
Ever unenthusiastic/disinterested for a whole week	1.9	2.3	4.0	2.0	1.8	1.5	1.7	1.5	1.6	-1.6	0.2	1.1
Qualifications: None of the above	0.3	0.7	1.4	-0.4	-0.9	-0.8	-0.6	-1.0	-0.7	1.2	-0.1	-1.1
Financial difficulties in last 2 years	3.8	5.1	7.3	0.6	2.4	2.5	2.3	2.7	2.5	-2.6	1.2	2.5
Mouth/teeth dental problems	0.2	0.3	1.5	1.2	0.4	0.4	0.3	0.4	0.3	-0.4	0.2	0.4
Heart attack	1.0	1.2	5.8	1.3	1.0	0.2	0.5	1.2	0.4	-0.9	-2.4	-0.3
Allergy	0.2	0.5	1.5	1.2	0.2	-0.4	-0.5	-0.7	-0.5	0.4	-1.1	-0.5
Pain all over the body in last month	1.5	1.6	2.7	1.3	1.5	1.3	1.3	0.8	1.1	-1.4	-1.0	1.6
Diabetes (self-reported)	0.9	1.4	7.5	2.7	0.9	0.6	0.5	1.1	0.6	-0.8	-1.0	0.1
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.8	-0.4	-0.9	-0.0	0.2	-0.3	-0.1	0.3	0.9	-0.3
Medication: Ramipril	0.6	0.8	3.6	1.6	0.8	-0.2	-0.1	0.5	-0.1	-0.2	-1.9	-0.2
Medication: Simvastatin	0.5	0.7	2.8	1.4	-0.6	-0.6	-0.5	-0.1	-0.6	-0.1	-1.7	-0.8
Fluid intelligence score	0.2	0.4	1.3	0.9	0.5	0.1	0.2	0.9	0.0	-0.4	-1.1	0.6
Illnesses of siblings	0.2	0.3	2.4	-0.2	0.1	0.2	-0.1	-0.2	0.2	0.1	1.6	0.4
Neuroticism score	0.2	0.4	1.2	1.1	0.2	-0.3	-0.3	-0.2	-0.3	0.1	-1.1	-0.7
Weight	0.1	0.7	2.3	1.5	-0.0	0.8	0.5	0.9	0.7	-0.6	1.0	0.6
Impedance of arm (right)	0.5	2.4	4.6	-1.1	-1.4	-1.7	-1.4	-2.1	-1.8	1.9	-0.1	-1.3
Arm fat percentage (right)	0.2	0.7	4.7	2.2	-0.5	-0.3	-0.5	0.4	-0.4	0.3	-0.9	-0.3
Trunk fat-free mass	0.3	1.5	5.2	0.0	0.2	1.4	1.0	0.9	1.3	-1.2	2.3	1.0
Hip circumference	0.1	0.5	1.9	1.4	-0.4	0.5	0.3	0.5	0.4	-0.0	1.2	0.3
Time employed in main current job	2.0	2.3	3.8	-1.4	-1.1	-1.6	-2.0	-1.3	-1.7	1.8	-1.5	-1.2
Alcohol intake versus 10 years previously	0.1	0.2	0.9	0.5	-0.4	-0.4	-0.3	-0.3	-0.4	0.1	-1.0	-0.4
Father’s age at death	0.2	0.3	1.7	-1.3	-0.6	-0.4	-0.6	-0.3	-0.5	0.2	-0.2	-0.1
Worrier / anxious feelings	0.2	0.3	0.8	0.9	0.1	-0.5	-0.2	-0.6	-0.5	0.4	-0.9	-0.7
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.0	14.2	3.8	1.6	0.8	0.7	1.5	0.6	-1.2	-2.3	0.4
Falls in the last year	1.9	2.6	4.1	1.2	1.8	1.9	2.0	1.3	2.0	-1.7	0.5	1.7
Hair/balding pattern: Pattern 3	0.1	0.2	0.5	0.0	-0.5	0.3	0.3	0.7	0.2	-0.2	0.5	0.6
Number of live births	0.2	0.3	0.9	-0.9	0.2	-0.3	-0.6	-0.6	-0.2	0.2	0.3	-0.6
Forced expiratory volume in 1-second (FEV1)	4.8	16.0	21.9	0.8	3.5	4.6	4.7	3.5	4.7	-4.2	4.0	4.5
Pulse rate	0.3	0.5	1.3	0.5	-0.7	-0.6	-0.4	-1.1	-0.5	0.8	0.0	-0.8
Happiness	0.1	0.1	0.6	0.8	0.1	-0.2	-0.1	0.2	-0.2	0.2	-0.6	-0.4
Noisy workplace	0.5	0.6	1.1	0.9	0.7	1.0	0.8	0.5	1.0	-1.0	-0.3	0.7
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.0	-0.1	0.9	1.0	0.9	0.4	0.9	-0.9	1.4	1.2
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.4	-0.0	0.3	0.2	0.6	0.6	0.2	-0.1	0.5	-0.3
Mouth/teeth dental problems: Dentures	1.8	3.0	4.2	-1.8	-1.8	-1.7	-1.8	-2.0	-1.7	1.7	-1.1	-1.8
Asthma	1.2	2.3	3.5	1.0	1.5	1.7	1.9	1.2	1.8	-1.9	0.0	1.5
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.7	-0.4	-0.5	-0.9	-0.6	-0.5	-0.8	0.8	-0.5	-0.9
Medication: Cholesterol lowering	1.5	2.3	5.6	2.4	1.0	0.8	0.9	1.9	0.9	-1.7	-2.3	0.4
Depression (self-reported)	0.7	0.8	1.6	0.7	0.5	1.1	1.2	0.7	1.0	-1.0	0.5	1.1
Medication: Lansoprazole	0.6	0.7	4.1	0.9	0.1	-0.4	-0.5	0.4	-0.5	0.1	-2.0	-0.3
Prospective memory result	0.1	0.1	0.2	0.2	-0.3	0.3	0.5	-0.1	0.2	-0.4	0.5	0.3
Lung cancer (father)	3.5	4.1	6.2	-0.1	-2.2	-2.2	-2.2	-2.2	-2.1	2.2	-1.4	-2.5
Illnesses of mother	0.6	0.8	3.8	-1.1	-0.2	0.6	0.2	-0.1	0.4	-0.2	2.0	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	5.8	18.5	26.0	1.5	4.1	5.0	5.1	4.0	5.1	-4.7	3.3	4.8
Pulse wave Arterial Stiffness index	2.1	2.4	4.1	0.3	-1.5	-1.7	-1.5	-1.5	-1.7	1.4	-2.0	-1.8
Impedance of arm (left)	0.5	2.1	4.1	-1.0	-1.4	-1.6	-1.2	-2.0	-1.7	1.9	-0.0	-1.3
Arm fat mass (right)	0.1	0.5	3.9	2.0	-0.2	0.2	-0.0	0.7	0.1	-0.2	-0.3	0.2
Trunk predicted mass	0.3	1.5	4.9	0.1	0.3	1.4	1.0	1.0	1.4	-1.2	2.2	1.1
Standing height	0.2	1.9	10.5	-2.1	-1.0	0.3	0.4	-0.8	0.2	0.2	3.2	0.3
Length of working week for main job	0.4	0.4	1.0	-0.2	0.2	0.7	0.8	0.4	0.8	-0.5	1.0	0.8
Exposure to tobacco smoke at home	0.6	0.7	2.6	-1.6	-0.5	-0.5	-0.5	-0.7	-0.6	0.8	1.0	-0.3
Breastfed as a baby	0.1	0.1	0.3	0.1	-0.3	-0.3	-0.2	0.0	-0.2	0.3	-0.5	-0.4
Tense / ‘highly strung’	0.4	0.6	1.6	-0.4	-0.4	-0.9	-0.5	-0.4	-0.6	0.4	-1.3	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	4.1	1.0	2.0	1.2	1.4	1.2	1.4	-1.4	0.5	1.0
Hair/balding pattern: Pattern 4	0.0	0.0	0.2	-0.4	0.1	-0.0	-0.1	0.0	-0.0	0.0	0.3	0.1
Birth weight of first child	1.0	1.7	2.6	-1.0	1.0	1.3	1.2	1.3	1.4	-1.3	1.5	1.6
Peak expiratory flow (PEF)	3.8	8.8	12.7	-1.0	2.0	3.4	3.3	2.5	3.4	-3.2	3.4	3.6
Pulse wave reflection index	0.2	0.2	0.9	0.3	-0.3	-0.4	-0.6	-0.1	-0.6	0.3	-0.9	-0.2
Ever highly irritable/argumentative for 2 days	1.2	1.5	4.0	2.0	1.4	1.0	1.3	1.4	1.2	-1.0	-0.1	0.5
Loud music exposure frequency	0.2	0.3	2.0	-1.4	-0.3	-0.2	-0.1	0.3	-0.2	-0.1	-0.1	-0.2
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.7	0.8	0.7	0.3	0.3	0.3	0.2	-0.7	-0.8	0.5
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	3.4	-0.5	0.5	0.8	1.0	0.8	1.0	-0.5	1.8	0.9
Blood clot in the leg (DVT)	1.0	1.3	7.1	2.7	1.0	0.6	0.6	1.3	0.7	-0.6	-0.5	0.2
Medication: Paracetamol	0.6	1.0	4.1	2.0	0.5	-0.3	-0.2	-0.4	-0.4	0.1	-2.0	-0.5
Headache pain in last month	0.6	1.0	1.4	0.7	-0.4	-1.1	-1.2	-0.7	-1.2	1.1	-1.2	-1.0
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	5.5	-2.4	-0.6	-0.3	-0.3	-1.3	-0.4	0.8	1.2	0.0
Glaucoma (self-reported)	0.2	0.2	0.5	-0.7	-0.4	-0.5	-0.4	-0.4	-0.3	0.6	-0.0	-0.1
Gout (self-reported)	0.2	0.3	1.2	-0.6	-0.4	-0.3	-0.1	-0.1	-0.3	0.4	1.1	0.5
Hypothyroidism/myxoedema (self-reported)	3.5	6.9	9.8	0.9	2.7	2.9	2.6	3.1	3.1	-3.1	0.7	3.1
Medication: Amlodipine	1.2	1.6	3.0	0.8	1.3	1.3	1.2	1.6	1.2	-1.7	-1.2	0.9
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.3	-0.3	-1.1	-1.0	-1.1	-0.9	-1.1	1.0	-0.6	-0.8
Birth weight	0.8	1.7	9.9	-3.1	-0.0	0.6	0.8	0.1	0.7	-0.6	1.8	0.8
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.4	1.2	-0.0	-0.6	-0.7	-0.7	-0.5	0.5	-0.9	-1.2
High blood pressure (siblings)	1.1	1.6	2.6	-0.7	-0.9	-1.4	-1.4	-1.0	-1.4	1.2	-1.6	-1.4
Forced vital capacity (FVC), Best measure	2.3	8.5	13.1	0.6	2.7	3.4	3.6	2.4	3.5	-3.0	2.7	3.2
Body fat percentage	0.2	0.7	2.8	1.7	-0.7	-0.7	-0.8	0.1	-0.8	0.7	-0.9	-0.6
Leg fat percentage (right)	0.3	0.9	4.5	2.1	-0.8	-0.6	-0.7	-0.1	-0.6	0.7	-0.8	-0.9
Arm fat-free mass (right)	0.4	1.8	3.1	0.5	0.7	1.6	1.3	1.4	1.5	-1.5	1.7	1.3
Exposure to tobacco smoke outside home	0.5	0.6	2.1	-0.1	0.9	0.7	0.9	0.1	0.8	-0.4	1.4	0.8
Comparative body size at age 10	1.3	3.5	8.6	0.6	2.0	1.8	1.7	2.9	1.8	-2.3	-0.8	1.7
Number of full brothers	2.1	2.6	5.6	-0.3	1.9	1.5	1.5	2.4	1.5	-1.7	1.0	1.7
Worry too long after embarrassment	0.5	0.8	1.8	1.3	-0.5	-0.7	-0.6	-1.1	-0.8	0.9	0.1	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	3.6	1.9	0.6	0.2	0.3	-0.2	0.2	0.1	-0.0	-0.1
Wheeze or whistling in the chest in last year	0.8	1.5	7.3	0.4	-0.9	-1.0	-1.0	-0.3	-0.9	0.6	-2.7	-1.4
Number of children fathered	1.2	1.4	2.6	-1.6	-1.2	-1.0	-1.2	-1.5	-1.2	0.7	-0.8	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	1.7	0.4	0.7	1.1	1.2	0.7	1.1	-0.8	1.2	1.3
Age at first live birth	0.3	0.6	1.2	1.0	1.0	0.8	0.8	0.4	0.6	-1.1	0.1	0.8
Pulse wave peak to peak time	2.4	2.8	4.9	-0.2	1.5	1.8	1.7	1.6	1.8	-1.6	2.2	1.9
Health satisfaction	1.1	1.4	3.6	1.2	-0.9	-1.2	-1.1	-0.5	-1.1	1.3	-1.3	-1.9
Shortness of breath walking on level ground	0.3	0.3	2.1	-0.4	0.1	-0.3	-0.2	0.3	-0.2	0.1	-1.5	-0.4
Qualifications: College or University degree	0.3	1.0	4.8	-1.7	0.0	0.3	0.4	-0.5	0.3	-0.1	2.2	0.6
Eye problems/disorders: None of the above	0.2	0.2	1.1	-1.0	0.1	0.3	0.4	0.7	0.2	-0.4	-0.1	0.1
Mouth/teeth dental problems: Loose teeth	0.4	0.5	2.2	1.4	-0.1	-0.2	-0.2	0.1	-0.2	0.0	-1.5	-0.7
Emphysema/chronic bronchitis	0.1	0.1	0.5	0.7	-0.1	0.1	0.3	0.0	0.2	-0.2	-0.4	-0.4
Medication for pain relief, constipation, heartburn	0.8	1.4	5.9	-2.3	-0.1	0.7	0.4	0.2	0.6	-0.3	2.4	0.8
Neck or shoulder pain in last month	0.0	0.1	0.2	0.5	0.2	0.2	0.3	0.3	0.1	0.0	-0.1	-0.1
Medication: Blood pressure	0.4	0.8	4.5	2.1	0.0	-0.2	-0.2	0.5	-0.0	-0.0	-1.0	-1.0
Angina (self-reported)	0.9	1.2	2.1	0.6	1.1	1.1	1.1	1.3	1.0	-1.5	-0.9	1.0
Migraine (self-reported)	0.1	0.1	0.4	-0.1	0.6	0.2	0.5	0.4	0.3	-0.0	-0.4	0.3
Medication: Ibuprofen	0.6	0.7	2.9	0.8	-0.3	-0.8	-0.6	-0.3	-0.7	0.5	-1.7	-1.0
Medication: Allopurinol	0.1	0.2	1.1	0.1	0.0	0.1	0.2	0.1	-0.0	0.1	1.1	0.6
Medication: Omeprazole	0.7	0.8	1.8	0.7	-0.4	-1.0	-0.8	-0.2	-0.9	0.9	-1.4	-1.2
Medication: Seretide 50 evohaler	1.4	1.6	2.9	1.5	1.7	1.3	1.4	1.1	1.4	-1.3	0.1	0.8
Mean time to correctly identify matches	0.6	1.2	5.6	2.4	0.9	0.9	1.0	0.3	0.9	-1.0	-0.4	0.9
Heart disease (mother)	0.9	1.1	4.7	0.6	-1.1	-0.9	-0.9	-0.3	-1.0	0.2	-2.2	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.4	-1.5	-1.0	-1.2	-0.9	-0.8	-1.3	1.1	-0.3	-0.8
Whole body fat mass	0.1	0.3	2.1	1.5	-0.4	-0.0	-0.2	0.4	-0.1	0.2	0.1	-0.0
Leg fat mass (right)	0.1	0.4	1.8	1.4	-0.7	-0.3	-0.4	0.1	-0.4	0.4	-0.0	-0.4
Arm predicted mass (right)	0.4	2.0	3.6	0.4	0.7	1.7	1.3	1.5	1.6	-1.6	1.9	1.3
Pulse rate, automated reading	0.2	0.5	2.2	1.5	0.4	-0.3	-0.2	-0.9	-0.2	0.4	-0.9	-0.4
Alcohol intake frequency.	1.4	3.3	5.5	-0.2	-1.7	-2.1	-1.8	-1.8	-1.9	2.3	-1.4	-2.1
Comparative height size at age 10	0.1	0.8	3.5	-1.9	0.1	0.7	0.7	0.4	0.6	-0.8	0.8	0.8
Number of full sisters	5.4	6.6	9.8	1.2	2.7	2.9	2.8	2.9	2.8	-3.1	0.3	3.0
Suffer from ‘nerves’	0.1	0.1	0.6	0.8	0.1	0.4	0.3	0.4	0.4	-0.4	-0.1	0.2
Overall health rating	0.9	1.9	5.1	2.3	1.6	0.7	0.8	1.4	0.6	-0.9	-2.2	0.7
Chest pain or discomfort	0.6	0.8	1.4	0.7	1.2	1.0	0.9	1.0	0.9	-1.1	-0.3	0.8
Had major operations	0.7	0.9	2.0	-1.4	0.4	0.8	0.7	0.9	0.7	-1.0	0.5	1.4
Age at last live birth	0.6	0.9	1.8	0.1	-0.5	-1.1	-1.1	-0.9	-1.2	0.8	-0.6	-1.3
Family relationship satisfaction	0.8	1.0	2.8	1.7	0.9	0.7	0.7	0.6	0.8	-0.2	1.6	0.6
Leg pain on walking	0.1	0.1	0.4	0.6	0.3	-0.2	0.0	-0.1	-0.0	0.2	-0.5	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.0	0.6	0.6	0.9	0.7	0.8	1.0	-0.8	1.4	0.5
Commuting to job workplace: Car/motor vehicle	0.9	1.0	3.4	0.9	1.8	0.7	1.0	1.0	0.8	-0.9	-0.8	0.7
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.8	0.1	-1.3	-1.1	-0.8	-1.7	-1.1	1.1	-0.4	-1.0
Medication: Aspirin	0.8	1.1	3.2	1.8	1.0	0.8	0.6	0.7	0.8	-1.3	-1.0	0.9
Supplements: Vitamin C	0.2	0.3	0.9	-0.9	0.2	0.4	0.4	-0.4	0.3	-0.3	1.0	0.2
Knee pain experienced in last month	1.5	2.3	3.3	-1.6	-1.7	-1.6	-1.4	-1.8	-1.5	1.8	0.2	-1.3
Hypertension (Self-reported)	1.1	3.2	10.6	3.2	2.0	1.4	1.5	1.6	1.5	-1.8	-1.1	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	6.0	7.0	9.8	-1.3	-2.9	-3.1	-3.1	-2.1	-3.1	3.1	-1.3	-2.9
Illnesses of father: Heart disease	0.8	1.1	2.4	0.7	1.5	1.2	1.2	0.8	1.1	-1.3	-0.2	1.0
Illnesses of siblings: Diabetes	2.1	2.6	3.6	1.7	1.5	1.7	1.9	1.9	1.8	-1.7	-0.2	1.4
Smoking status: Previous	1.2	1.9	3.1	-0.8	-0.6	-1.5	-1.7	-1.3	-1.4	1.2	-1.6	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.1	0.5	0.7	-0.4	-0.1	-0.1	-0.2	-0.1	0.4	0.5	-0.4
Whole body fat-free mass	0.3	1.7	4.6	0.3	0.4	1.5	1.2	1.2	1.4	-1.3	2.1	1.3
Leg fat-free mass (right)	0.4	2.3	3.8	0.7	0.7	1.8	1.5	1.4	1.6	-1.6	2.0	1.7
Arm fat percentage (left)	0.2	0.8	5.7	2.4	-0.3	-0.0	-0.2	0.6	-0.2	0.1	-0.8	-0.0
Average weekly red wine intake	0.3	0.5	1.4	-1.2	-0.7	-0.5	-0.4	-0.9	-0.5	0.4	0.5	-0.5
Handedness (chirality/laterality): Left-handed	0.9	1.1	4.0	1.7	1.2	0.2	0.5	1.0	0.4	-0.7	-2.0	-0.2
Mood swings	0.3	0.5	1.4	1.2	-0.1	-0.5	-0.4	-0.8	-0.5	0.5	-0.9	-0.9
Loneliness, isolation	1.7	2.4	4.2	2.1	1.3	1.7	1.9	1.0	1.6	-1.3	1.1	1.6
Long-standing illness, disability or infirmity	0.4	0.6	0.9	0.0	-0.8	-0.9	-1.0	-0.8	-0.9	0.8	-0.9	-0.5
Ever had bowel cancer screening	1.1	1.3	7.1	-2.7	-1.0	-0.9	-0.8	-0.4	-0.9	0.8	-0.3	-0.6
Diabetes diagnosed by doctor	0.8	1.3	6.9	2.6	1.0	0.6	0.5	1.0	0.6	-0.8	-1.2	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.6	-0.5	-0.4	-0.5	-0.8	-0.8	-0.6	0.4	-0.3	0.1
Friendships satisfaction	2.4	3.0	5.8	0.7	1.2	1.9	1.9	1.6	1.9	-1.4	2.4	1.9
Qualifications: nursing, teaching	0.4	0.7	1.6	-0.9	-0.9	-0.9	-1.3	-0.5	-0.9	0.7	-0.2	-0.6
Commuting to job workplace: Walk	0.9	1.0	2.0	-0.9	-1.2	-0.9	-1.2	-1.4	-0.9	1.0	0.2	-1.0
Eye problems/disorders: Cataract	0.3	0.4	2.5	0.0	-0.0	0.0	0.2	-0.6	0.1	0.4	1.6	0.5
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.0	-1.0	-0.2	-0.2	-0.3	0.7	-0.3	-0.2	-0.8	-0.0
Medication for cholesterol	0.0	0.1	0.4	-0.3	-0.1	0.1	0.1	0.0	0.1	0.3	0.7	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.9	-1.4	-0.5	-0.8	-0.9	-1.1	-0.8	0.8	-0.5	-0.5
Back pain experienced in last month	3.1	4.6	6.3	-2.5	-2.3	-2.2	-1.9	-2.4	-2.3	2.4	0.1	-2.1
Mineral and other dietary supplements	0.2	0.2	1.4	-0.0	-0.5	0.1	-0.0	0.5	0.0	0.4	1.2	0.3
Breast cancer (self-reported)	0.4	0.5	1.1	-0.7	-0.7	-0.8	-0.7	-1.0	-0.7	0.9	0.2	-0.5
Asthma (self-reported)	0.8	1.7	2.6	0.7	1.4	1.5	1.6	1.2	1.6	-1.6	-0.1	1.2
Osteoporosis (self-reported)	0.9	1.1	1.8	-1.3	-1.3	-1.1	-1.2	-1.3	-1.1	0.9	0.5	-0.6
Osteoarthritis (self-reported)	3.0	3.9	7.8	-2.8	-2.1	-2.0	-1.9	-2.4	-1.9	2.0	0.1	-1.5
Medication: Aspirin	0.6	0.8	3.6	1.9	0.8	0.5	0.3	0.3	0.5	-0.9	-0.9	0.7
Medication: Gliclazide	4.9	5.5	7.8	2.1	2.4	2.6	2.6	2.4	2.8	-2.5	0.8	2.2
Illnesses of father: None of the above (group 1)	0.5	0.6	0.7	-0.6	-0.7	-0.8	-0.8	-0.8	-0.8	0.8	0.8	-0.6
Smoking status: Current	0.5	0.7	1.2	-0.9	-1.0	-0.8	-0.7	-1.0	-0.8	1.1	0.4	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.0	8.4	12.1	0.8	3.2	3.3	3.3	2.9	3.5	-3.2	1.0	3.4
Whole body water mass	0.3	1.8	4.0	0.3	0.6	1.6	1.3	1.3	1.5	-1.4	2.0	1.3
Leg predicted mass (right)	0.5	2.5	3.9	0.7	0.8	1.8	1.6	1.5	1.7	-1.7	2.0	1.8
Arm fat mass (left)	0.1	0.4	3.2	1.8	-0.2	0.3	-0.0	0.7	0.1	-0.2	-0.2	0.2
Number of self-reported non-cancer illnesses	0.5	0.8	3.3	1.8	0.4	-0.1	-0.2	0.8	-0.1	-0.4	-1.8	-0.0
Average weekly champagne plus white wine intake	1.3	1.8	3.0	0.7	1.4	1.6	1.4	1.2	1.7	-1.7	0.3	1.4
Miserableness	0.2	0.3	0.8	0.9	0.6	0.5	0.5	0.5	0.4	-0.6	-0.1	0.3
Guilty feelings	0.7	1.0	4.6	1.4	0.3	-0.4	-0.5	-0.0	-0.5	0.1	-2.2	-1.2
Wears glasses or contact lenses	0.9	1.0	2.6	-1.6	-0.7	-1.0	-1.0	-1.1	-0.9	0.7	-0.7	-0.8
Ever taken oral contraceptive pill	2.8	3.1	4.2	2.0	1.7	2.0	1.9	1.2	2.0	-2.0	0.4	1.9
Hearing aid user	0.4	0.5	1.5	-1.2	0.3	0.5	0.3	0.3	0.3	-0.4	1.2	0.7
Mother’s age at death	0.6	0.7	1.4	0.9	1.2	0.7	0.8	1.0	0.6	-0.8	-0.5	0.7
Financial situation satisfaction	0.4	0.4	0.9	0.4	0.9	0.6	0.4	0.9	0.6	-0.7	0.0	0.8
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.7	-1.3	-0.5	-0.1	0.3	-0.5	0.0	0.3	0.8	-0.3
Commuting to job workplace: Public transport	0.4	0.5	1.1	0.2	-1.1	-0.6	-0.8	-0.8	-0.6	0.7	0.2	-0.6
Eye problems/disorders: Glaucoma	0.6	0.7	1.5	-0.6	-0.8	-0.9	-0.8	-1.0	-0.8	1.2	-0.3	-0.6
Medication: Blood pressure	0.2	0.3	1.5	1.2	0.1	-0.0	0.1	-0.1	-0.1	-0.1	-1.1	-0.3
Pain type(s) experienced in last month: Hip pain	0.7	0.9	6.8	-0.2	0.3	-0.5	-0.2	0.2	-0.5	0.0	-2.6	-0.5
Supplements: Fish oil (including cod liver oil)	0.2	0.3	1.2	1.1	0.6	0.3	0.4	-0.2	0.2	-0.6	-0.8	0.3
High cholesterol (Self-reported)	0.2	0.3	1.7	0.4	-0.4	-0.3	-0.3	-0.3	-0.2	-0.2	-1.3	-0.2
Medication: Bendroflumethiazide	1.9	3.0	5.3	0.0	-1.6	-1.9	-1.9	-1.2	-1.9	1.4	-2.3	-2.2
Medication: Paracetamol	1.3	2.0	7.3	1.6	-0.2	-1.2	-1.1	-1.2	-1.3	0.9	-2.7	-1.3
Medication: Lisinopril	0.1	0.1	0.4	0.4	0.0	-0.0	0.0	-0.4	0.1	0.1	-0.3	-0.7
Medication: Atorvastatin	1.4	1.7	2.7	-0.0	1.6	1.5	1.3	1.6	1.6	-1.5	0.3	1.3
Illnesses of father: High blood pressure	5.6	7.0	10.0	1.7	2.7	3.2	2.8	2.4	3.0	-3.0	1.3	3.1
Alcohol drinker status: Never	0.2	0.2	1.2	1.1	0.4	0.3	0.4	0.3	0.5	-0.2	-0.2	0.5
Ever smoked	0.8	1.5	2.8	-1.7	-1.1	-1.2	-1.1	-1.7	-1.2	1.1	0.0	-1.1
Basal metabolic rate	0.3	1.6	3.7	0.7	0.4	1.5	1.2	1.2	1.4	-1.3	1.9	1.2
Leg fat percentage (left)	0.3	0.9	3.5	1.9	-0.9	-0.7	-0.8	-0.1	-0.7	0.8	-1.0	-0.9
Arm fat-free mass (left)	0.2	0.8	1.8	0.5	0.3	1.1	0.8	0.9	1.1	-0.9	1.4	0.7
Number of operations (self-reported)	0.3	0.5	1.6	-1.3	-0.8	-0.4	-0.4	-0.0	-0.6	-0.0	-1.1	0.2
Average weekly beer plus cider intake	0.3	0.5	1.4	-0.3	0.9	0.5	0.7	1.2	0.5	-0.7	-0.1	0.9
Irritability	1.1	1.9	3.4	-0.3	-1.2	-1.6	-1.5	-1.7	-1.5	1.3	-0.7	-1.9
Risk taking	0.8	1.2	2.6	-1.4	-0.7	-0.9	-0.9	-1.6	-0.8	1.0	1.0	-1.0
Ever had prostate specific antigen (PSA) test	2.0	2.3	7.3	-2.7	-1.6	-1.3	-1.3	-1.3	-1.4	1.5	-0.0	-1.1
Fractured/broken bones in last 5 years	0.3	0.3	1.0	-0.1	1.0	0.4	0.2	0.9	0.2	-0.5	-0.8	0.2
Age started oral contraceptive pill	0.2	0.2	0.8	0.9	0.3	0.3	0.3	0.3	0.4	-0.2	0.5	0.2
Diastolic blood pressure, automated reading	0.2	0.7	4.8	2.2	-0.2	-0.3	-0.6	-0.5	-0.4	0.6	0.2	-0.7
Ever depressed for a whole week	0.6	0.8	1.4	0.7	1.2	0.9	0.9	1.0	1.0	-1.0	-0.0	0.7
Unable to work because of sickness or disability	0.9	1.1	3.5	0.3	1.4	0.8	0.7	0.8	0.6	-1.1	-1.9	1.0
Commuting to job workplace: Cycle	2.1	2.5	5.8	-1.5	0.7	1.7	1.5	1.3	1.6	-1.3	2.4	1.8
Myopia	0.4	0.6	1.7	-0.4	1.2	0.5	0.5	0.9	0.4	-0.8	-1.3	0.7
Vascular/heart problems diagnosed by doctor	0.9	2.4	10.0	-3.2	-1.6	-1.0	-1.0	-1.2	-1.1	1.4	1.5	-0.3
Cholesterol lowering medication	0.1	0.2	0.5	-0.2	-0.5	-0.3	-0.5	-0.7	-0.4	0.3	-0.5	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.8	0.6	-0.6	-1.1	-0.8	-0.3	-0.9	0.9	-1.4	-1.2
Pain experienced in last month	2.3	3.8	5.9	0.7	1.6	2.3	2.0	1.5	2.3	-2.2	1.7	2.4
Supplements: Calcium	0.7	0.8	1.4	-1.2	-0.7	-0.9	-0.9	-0.9	-1.0	0.8	-0.3	-0.8
Basal cell carcinoma (self-reported)	0.2	0.2	0.4	0.3	0.4	0.5	0.6	0.1	0.4	-0.2	0.7	0.6
Heart attack/myocardial infarction (self-reported)	1.1	1.4	6.6	1.5	1.0	0.2	0.4	1.2	0.3	-0.8	-2.6	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	6.2	2.5	0.8	0.5	0.5	1.2	0.6	-0.6	-0.5	0.1
Heart disease (siblings)	2.1	2.6	3.4	-1.1	-1.8	-1.8	-1.4	-1.5	-1.8	1.5	-1.6	-1.8
Alcohol drinker status: Previous	1.7	1.9	3.6	-0.4	-0.8	-1.6	-1.7	-0.9	-1.5	1.3	-1.9	-1.6
Pack years of smoking	0.3	0.5	1.3	-1.2	-0.8	-0.6	-0.2	-0.5	-0.4	0.7	0.9	-0.3
Impedance of whole body	0.6	3.0	4.6	-1.6	-1.6	-1.9	-1.5	-2.1	-1.9	2.1	-0.0	-1.6
Leg fat mass (left)	0.1	0.4	1.6	1.3	-0.8	-0.4	-0.5	0.0	-0.4	0.5	-0.1	-0.5
Arm predicted mass (left)	0.2	1.0	1.6	0.3	0.4	1.2	0.8	1.2	1.2	-1.1	1.3	0.8