[Hub]/) : Traits : Crohns Disease (2012) : ← →

chr5:149,124,105-151,236,214

Best TWAS P=1.98e-18 · Best GWAS P=1.62e-17 conditioned to 0.186

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
48	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DCTN4	0.18	0.03	blup	51	0.03	1.8e-04	7.76	8.8	2.0e-18	0.86	0.00	0.99	TRUE
41	NTR	Blood	ANXA6	0.10	0.02	enet	31	0.05	2.1e-15	3.26	6.6	5.5e-11	0.30	1.00	0.00	TRUE
57	The Cancer Genome Atlas	Soft Tissue Sarcoma	IRGM	0.08	0.05	lasso	8	0.05	5.3e-04	8.44	8.4	3.1e-17	0.99	0.01	0.94	FALSE
52	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZNF300	0.05	0.04	lasso	2	0.03	9.3e-05	8.12	8.3	1.0e-16	0.98	0.02	0.97	FALSE
39	GTEx	Thyroid	ZNF300P1	0.57	0.58	lasso	9	0.60	7.8e-57	8.12	8.3	1.1e-16	0.97	0.09	0.91	FALSE
60	The Cancer Genome Atlas	Thyroid Carcinoma	ZNF300	0.03	0.01	blup	45	0.01	8.1e-02	7.77	8.3	1.2e-16	0.89	0.02	0.37	FALSE
53	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	LOC134466	0.12	0.09	lasso	5	0.08	2.0e-04	8.39	8.2	1.7e-16	0.98	0.00	0.98	FALSE
49	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IRGM	0.17	0.09	lasso	4	0.08	1.2e-09	8.22	8.2	2.1e-16	0.99	0.04	0.96	FALSE
28	GTEx	Muscle Skeletal	ZNF300P1	0.49	0.41	enet	20	0.51	2.9e-58	8.12	8.2	3.4e-16	0.95	0.09	0.91	FALSE
16	GTEx	Breast Mammary Tissue (Female)	ZNF300P1	0.66	0.33	enet	22	0.44	1.1e-14	8.12	8.1	4.6e-16	0.90	0.10	0.90	FALSE
32	GTEx	Pancreas	ZNF300P1	0.58	0.60	lasso	4	0.60	7.6e-31	8.12	8.1	4.6e-16	0.98	0.09	0.91	FALSE
5	GTEx	Artery Coronary	ZNF300P1	0.73	0.71	lasso	3	0.70	5.9e-32	8.12	8.1	4.9e-16	0.99	0.09	0.91	FALSE
35	GTEx	Skin Sun Exposed Lower leg	ZNF300P1	0.44	0.44	lasso	3	0.46	1.3e-41	8.12	8.1	5.3e-16	0.97	0.09	0.91	FALSE
8	GTEx	Brain Cerebellar Hemisphere	ZNF300P1	0.72	0.55	lasso	8	0.52	9.1e-16	8.12	8.1	7.4e-16	0.97	0.07	0.93	FALSE
6	GTEx	Artery Tibial	ZNF300P1	0.66	0.65	enet	14	0.69	1.5e-74	8.12	8.0	8.9e-16	0.96	0.09	0.91	FALSE
59	The Cancer Genome Atlas	Testicular Germ Cell Tumors	LOC134466	0.43	0.04	enet	15	0.08	7.2e-04	8.12	8.0	1.0e-15	0.91	0.02	0.92	FALSE
23	GTEx	Esophagus Muscularis	ZNF300P1	0.61	0.61	enet	17	0.62	9.7e-48	7.14	7.9	2.6e-15	0.93	0.41	0.59	FALSE
20	GTEx	Esophagus Gastroesophageal Junction	ZNF300P1	0.74	0.64	lasso	4	0.69	2.7e-33	8.12	7.9	2.9e-15	0.95	0.17	0.83	FALSE
31	GTEx	Ovary	ZNF300P1	0.36	0.12	lasso	5	0.11	1.2e-03	7.31	7.9	2.9e-15	0.95	0.06	0.84	FALSE
2	GTEx	Adipose Subcutaneous	ZNF300P1	0.64	0.54	lasso	9	0.63	5.3e-66	7.14	7.9	3.5e-15	0.94	0.29	0.71	FALSE
27	GTEx	Lung	ZNF300P1	0.57	0.46	lasso	8	0.58	8.1e-54	7.14	7.9	3.6e-15	0.94	0.29	0.71	FALSE
14	GTEx	Breast Mammary Tissue	ZNF300P1	0.49	0.39	enet	20	0.47	7.7e-27	7.14	7.8	5.0e-15	0.93	0.31	0.69	FALSE
30	GTEx	Nerve Tibial	ZNF300P1	0.70	0.63	lasso	4	0.70	5.8e-68	7.14	7.8	6.2e-15	0.93	0.80	0.20	FALSE
40	GTEx	Vagina	ZNF300P1	0.61	0.17	lasso	11	0.27	6.2e-07	7.14	7.8	6.2e-15	0.93	0.06	0.93	FALSE
25	GTEx	Heart Left Ventricle	ZNF300P1	0.53	0.47	enet	20	0.51	3.3e-31	7.14	7.8	6.5e-15	0.89	0.31	0.69	FALSE
55	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LOC134466	0.10	0.05	enet	7	0.05	2.1e-06	8.12	7.7	1.1e-14	0.89	0.01	0.98	FALSE
45	The Cancer Genome Atlas	Breast Invasive Carcinoma	DCTN4	0.10	0.02	enet	11	0.03	1.9e-07	7.76	7.7	1.6e-14	0.83	0.00	1.00	FALSE
34	GTEx	Skin Not Sun Exposed Suprapubic	ZNF300P1	0.53	0.49	lasso	5	0.50	7.4e-31	7.14	7.7	1.9e-14	0.91	0.83	0.17	FALSE
3	GTEx	Adipose Visceral Omentum	ZNF300P1	0.67	0.43	enet	12	0.54	5.2e-33	8.12	7.6	2.1e-14	0.93	0.10	0.90	FALSE
37	GTEx	Stomach	ZNF300P1	0.57	0.41	enet	31	0.48	7.4e-26	7.14	7.6	2.9e-14	0.88	0.49	0.51	FALSE
44	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LOC134466	0.13	0.09	lasso	4	0.09	8.0e-08	7.31	7.6	3.3e-14	0.91	0.15	0.85	FALSE
38	GTEx	Testis	ZNF300	0.28	0.18	lasso	6	0.18	2.1e-08	8.12	7.5	4.7e-14	0.96	0.04	0.96	FALSE
4	GTEx	Adrenal Gland	ZNF300P1	0.53	0.15	enet	16	0.14	1.0e-05	8.12	7.4	1.3e-13	0.92	0.05	0.95	FALSE
10	GTEx	Brain Frontal Cortex BA9	ZNF300P1	0.34	0.15	enet	22	0.32	4.4e-09	8.12	7.4	1.3e-13	0.80	0.04	0.92	FALSE
36	GTEx	Spleen	ZNF300P1	0.69	0.50	lasso	7	0.47	9.8e-14	7.14	7.4	1.9e-13	0.88	0.29	0.71	FALSE
33	GTEx	Pituitary	ZNF300P1	0.72	0.41	lasso	14	0.46	4.1e-13	7.31	7.3	2.1e-13	0.90	0.10	0.90	FALSE
19	GTEx	Colon Transverse	ZNF300P1	0.51	0.41	enet	8	0.47	9.2e-25	7.14	7.3	3.2e-13	0.89	0.80	0.20	FALSE
22	GTEx	Esophagus Muscularis	ZNF300	0.10	0.10	enet	12	0.10	9.6e-07	8.22	7.3	3.5e-13	0.90	0.04	0.96	FALSE
24	GTEx	Heart Atrial Appendage	ZNF300P1	0.61	0.39	enet	19	0.47	2.0e-23	8.12	7.2	7.4e-13	0.93	0.14	0.86	FALSE
26	GTEx	Liver	ZNF300P1	0.32	0.18	lasso	4	0.15	7.3e-05	7.14	7.2	8.3e-13	0.88	0.16	0.82	FALSE
15	GTEx	Breast Mammary Tissue (Male)	ZNF300P1	0.36	0.24	lasso	3	0.21	1.1e-05	7.14	7.1	1.1e-12	0.85	0.11	0.75	FALSE
13	GTEx	Brain Putamen basal ganglia	ZNF300P1	0.44	0.28	lasso	4	0.34	4.9e-09	7.14	7.1	1.5e-12	0.84	0.08	0.91	FALSE
18	GTEx	Colon Sigmoid	ZNF300P1	0.65	0.34	enet	24	0.50	3.4e-20	7.14	6.7	1.7e-11	0.81	0.68	0.32	FALSE
21	GTEx	Esophagus Mucosa	ZNF300P1	0.55	0.44	enet	20	0.50	4.0e-38	7.14	6.6	3.4e-11	0.88	0.77	0.23	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ZNF300P1	0.36	0.18	lasso	6	0.36	9.5e-46	8.12	6.5	8.4e-11	0.77	0.07	0.93	FALSE
11	GTEx	Brain Hypothalamus	ZNF300P1	0.68	0.24	lasso	16	0.35	4.1e-09	8.12	6.4	1.6e-10	0.80	0.05	0.90	FALSE
9	GTEx	Brain Cortex	ZNF300P1	0.41	0.15	lasso	4	0.31	2.7e-09	7.31	6.4	1.8e-10	0.71	0.14	0.67	FALSE
7	GTEx	Brain Caudate basal ganglia	ZNF300P1	0.60	0.17	lasso	8	0.35	7.7e-11	8.12	6.3	3.2e-10	0.77	0.07	0.92	FALSE
42	ROSMAP	Brain Pre-frontal Cortex	ZNF300P1	0.36	0.31	bslmm	516	0.48	2.8e-69	8.12	6.3	3.5e-10	0.81	0.06	0.94	FALSE
50	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LOC134466	0.05	0.00	blup	46	0.01	1.1e-02	-1.99	6.3	3.7e-10	0.69	0.04	0.36	FALSE
58	The Cancer Genome Atlas	Stomach Adenocarcinoma	LOC134466	0.18	0.08	enet	13	0.10	5.7e-08	-1.99	5.7	1.1e-08	0.58	0.50	0.44	FALSE
17	GTEx	Cells Transformed fibroblasts	ZNF300P1	0.35	0.26	lasso	7	0.38	2.3e-30	-1.99	5.7	1.2e-08	0.65	1.00	0.00	FALSE
29	GTEx	Nerve Tibial	ZNF300	0.13	0.05	lasso	4	0.09	7.0e-07	-2.51	5.7	1.5e-08	0.60	0.23	0.55	FALSE
56	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC134466	0.17	0.04	enet	8	0.08	1.7e-08	-2.43	5.5	2.9e-08	0.64	0.50	0.48	FALSE
12	GTEx	Brain Nucleus accumbens basal ganglia	ZNF300P1	0.35	0.16	enet	11	0.18	1.3e-05	8.12	5.5	3.3e-08	0.67	0.05	0.87	FALSE
47	The Cancer Genome Atlas	Colon Adenocarcinoma	LOC134466	0.22	0.04	lasso	5	0.11	7.2e-07	-2.10	5.5	3.5e-08	0.63	0.32	0.60	FALSE
54	The Cancer Genome Atlas	Lung Adenocarcinoma	LOC134466	0.13	0.09	lasso	4	0.11	1.8e-12	-2.43	5.4	5.2e-08	0.58	0.91	0.09	FALSE
51	The Cancer Genome Atlas	Brain Lower Grade Glioma	LOC134466	0.09	0.06	lasso	4	0.07	1.7e-08	-1.99	5.4	6.8e-08	0.59	0.31	0.68	FALSE
46	The Cancer Genome Atlas	Breast Invasive Carcinoma	LOC134466	0.12	0.10	enet	7	0.13	2.3e-25	-2.43	5.2	2.0e-07	0.52	1.00	0.00	FALSE
43	YFS	Blood	RPS14	0.03	0.00	bslmm	480	0.01	2.1e-04	-0.71	5.2	2.4e-07	0.41	0.05	0.07	FALSE