TWAS hub - IRGM

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Kidney Renal Clear Cell Carcinoma	0.167	0.0897	4.3e-10	0.085	0.062	0.073	NA	0.083	8.0e-10	1.8e-07	1.4e-08	NA	1.2e-09
2	TCGA	Soft Tissue Sarcoma	0.080	0.0440	2.5e-04	0.053	0.045	0.041	NA	0.051	4.2e-04	1.2e-03	1.8e-03	NA	5.3e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Crohns Disease (2012)	43.1	69.4	71.2	8.2	8.4
Crohns Disease (2017)	37.8	82.9	83.7	9.1	9.2
Irritable Bowel Disease (IBD)	26.1	62.3	63.2	8.0	7.8
Ulcerative Colitis (UC)	10.2	19.1	20.3	4.5	4.2
Chronic bronchitis/emphysema (father)	9.3	10.9	11.8	-3.2	-3.4
Ulcerative Colitis	7.0	10.1	10.5	3.2	3.1
Loud music exposure frequency	6.2	6.8	6.8	-2.6	-2.6
Supplements: Zinc	5.7	6.2	6.5	-2.6	-2.4
Lung cancer (father)	5.3	6.2	6.5	-2.5	-2.4
Severe depression (siblings)	5.0	5.6	6.4	-2.2	-2.5
Long-standing illness, disability or infirmity	4.7	7.2	7.3	2.7	2.7
Average weekly spirits intake	4.0	4.9	5.2	2.3	2.1
Commuting to job workplace: Car/motor vehicle	3.8	4.3	5.0	1.9	2.2
Pulse rate	3.2	5.4	5.7	-2.4	-2.2
Ever had bowel cancer screening	3.2	3.8	3.9	2.0	1.9
Qualifications: nursing, teaching	3.2	4.9	5.0	-2.2	-2.2
Hair/balding pattern: Pattern 2	3.0	3.8	4.0	-1.9	-2.0
Heart disease (mother)	3.0	3.7	4.5	-1.7	-2.1
Ever had stillbirth, spontaneous miscarriage or termination	2.9	3.1	3.2	-1.7	-1.8
Commuting to job workplace: Public transport	2.8	3.4	4.0	-1.6	-2.0
Angina (self-reported)	2.7	3.5	3.6	1.9	1.9
Schizophrenia vs Biploar Disorder	2.5	3.3	3.4	-1.8	-1.8
High blood pressure (mother)	2.5	3.5	3.6	-1.9	-1.8
Pulse wave reflection index	2.5	3.1	3.1	1.8	1.8
Heart attack/myocardial infarction (self-reported)	2.5	3.2	4.0	2.0	1.6
Medication: Atenolol	2.3	2.8	3.7	1.4	1.9
Average weekly champagne plus white wine intake	2.3	3.1	3.8	-1.6	-2.0
Angina	2.2	2.9	3.1	1.7	1.8
Medication: Co-codamol	2.2	2.5	2.7	-1.6	-1.5
Heart attack	2.2	2.8	3.5	1.9	1.4
Commuting to job workplace: Walk	2.2	2.4	2.8	1.7	1.4
Mean Putamen Volume	2.1	2.4	2.6	1.6	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.1	2.5	3.5	1.9	1.2
Eye problems/disorders: None of the above	2.0	2.3	2.7	1.4	1.6
Asthma (self-reported)	2.0	4.0	5.2	2.3	1.7
Type 2 Diabetes (T2D) (2012)	1.9	2.1	3.1	1.8	1.1
Asthma	1.8	3.6	4.8	2.2	1.6
Body Mass Index (BMI) (2010)	1.7	2.3	2.4	1.5	1.6
Age when periods started (menarche)	1.7	4.0	4.7	2.2	1.8
Sitting height	1.7	12.0	13.2	-3.6	-3.3
Medication: Ventolin 100micrograms inhaler	1.7	2.1	3.3	1.8	1.0
Ever unenthusiastic/disinterested for a whole week	1.6	1.9	2.3	1.5	1.2
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.4	4.3	-2.1	-1.6
Mineral and other dietary supplements	1.6	2.2	2.6	-1.3	-1.6
Schizophrenia (2014)	1.5	3.3	4.2	-2.0	-1.6
Number of children fathered	1.5	1.7	2.0	-1.2	-1.4
Neck or shoulder pain in last month	1.5	2.1	2.2	-1.5	-1.4
Time employed in main current job	1.4	1.6	2.1	1.1	1.5
Medication: Cholesterol lowering	1.4	2.2	2.9	-1.3	-1.7
Exposure to tobacco smoke at home	1.4	1.5	1.7	-1.3	-1.2
Financial situation satisfaction	1.4	1.8	2.1	1.5	1.2
Medication: Lisinopril	1.4	1.8	2.2	-1.2	-1.5
Myopia	1.4	2.0	2.3	-1.3	-1.5
Triglycerides	1.3	2.1	2.1	1.5	1.4
Ever used hormone-replacement therapy (HRT)	1.3	1.7	2.0	-1.4	-1.2
Ever had hysterectomy (womb removed)	1.3	1.5	1.9	1.4	1.1
Number of incorrect matches in round	1.3	2.2	2.3	-1.4	-1.5
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	1.7	-1.2	-1.3
Alcohol intake frequency.	1.3	3.0	3.4	-1.6	-1.9
Supplements: Fish oil (including cod liver oil)	1.3	1.6	1.9	1.2	1.4
Coronary Artery Disease (CAD)	1.2	1.5	1.9	1.0	1.4
Allergy	1.2	2.7	3.5	-1.9	-1.4
Illnesses of father: None of the above (group 1)	1.2	1.5	1.8	1.4	1.1
Eye problems/disorders: Diabetes related eye disease	1.1	1.3	1.3	1.1	1.1
Taking other prescription medications	1.1	1.7	2.0	-1.4	-1.2
Pulse rate, automated reading	1.1	3.6	3.8	-1.9	-1.9
Had major operations	1.1	1.3	1.5	1.2	1.0
Ever taken oral contraceptive pill	1.1	1.2	1.2	1.1	1.1
Illnesses of father: High blood pressure	1.1	1.4	1.6	-1.3	-1.1
Fed-up feelings	1.0	1.7	1.9	1.2	1.4
Hair/balding pattern: Pattern 4	1.0	2.5	2.8	1.5	1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	1.3	1.0	1.1
Eye problems/disorders: Cataract	1.0	1.2	1.4	-1.0	-1.2
Supplements: Glucosamine	0.9	1.2	1.4	1.2	1.0
Medication: Ramipril	0.9	1.2	1.5	1.2	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	1.4	-1.2	-1.0
Number of full brothers	0.9	1.1	1.4	-0.9	-1.2
Medication: Seretide 50 evohaler	0.9	1.0	1.4	1.2	0.8
Risk taking	0.9	1.4	1.4	-1.2	-1.2
Supplements: Calcium	0.9	1.0	1.3	-1.1	-0.8
Major Depression (MDD)	0.8	1.0	1.4	1.2	0.8
Leg predicted mass (left)	0.8	4.1	4.9	-2.2	-1.8
Alcohol usually taken with meals	0.8	1.3	1.4	-1.0	-1.2
Birth weight	0.8	1.8	2.0	1.3	1.4
Qualifications: College or University degree	0.8	2.5	2.6	-1.5	-1.6
Breast cancer (self-reported)	0.8	1.0	1.1	0.9	1.1
Alzheimer’s Disease (in mother)	0.7	0.9	1.4	0.6	1.2
Age at First Birth	0.7	1.1	1.3	-1.2	-0.9
Leg fat-free mass (left)	0.7	3.9	4.7	-2.2	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	2.0	-1.4	-1.1
Qualifications: CSEs or equivalent	0.7	1.0	1.2	0.9	1.1
Hayfever, allergic rhinitis or eczema	0.7	1.4	1.7	1.3	1.1
Stomach or abdominal pain in last month	0.7	0.9	1.0	1.0	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	1.2	1.1	1.1
Falls in the last year	0.7	0.9	1.0	0.9	1.0
Number of live births	0.7	0.9	1.2	0.8	1.1
Standing height	0.7	6.5	7.4	-2.7	-2.4
Length of working week for main job	0.7	0.8	0.9	-0.9	-0.8
Breastfed as a baby	0.7	0.9	1.2	-1.1	-0.8
Exposure to tobacco smoke outside home	0.7	0.9	1.1	-1.1	-0.8
Whole body fat mass	0.7	2.9	3.3	-1.8	-1.6
Leg fat mass (right)	0.7	2.6	3.2	-1.8	-1.4
Number of full sisters	0.7	0.9	1.2	1.1	0.7
Illnesses of siblings: Diabetes	0.7	0.9	1.1	1.0	0.8
Medication: Atorvastatin	0.7	0.8	0.9	-1.0	-0.9
Average weekly beer plus cider intake	0.7	1.0	1.2	0.9	1.1
Reaction Time	0.6	1.1	1.3	0.9	1.1
LDL Cholesterol	0.6	0.9	1.1	1.0	0.9
Lupus	0.6	0.9	0.9	0.9	1.0
Medication for hormone replacement therapy	0.6	0.6	0.7	-0.8	-0.7
Trunk fat mass	0.6	2.7	3.1	-1.8	-1.5
Financial difficulties in last 2 years	0.6	0.8	0.9	0.9	0.9
Hayfever/allergic rhinitis (self-reported)	0.6	0.7	1.1	-0.6	-1.1
Weight	0.6	2.8	3.3	-1.8	-1.5
Hair/balding pattern: Pattern 3	0.6	0.9	1.3	1.1	0.7
Illnesses of mother	0.6	0.7	0.9	0.9	0.8
Arm fat mass (right)	0.6	2.3	2.6	-1.6	-1.4
Peak expiratory flow (PEF)	0.6	1.4	1.5	1.2	1.1
Health satisfaction	0.6	0.7	0.9	-0.7	-1.0
Mouth/teeth dental problems: Loose teeth	0.6	0.7	0.8	-0.9	-0.7
Family relationship satisfaction	0.6	0.8	0.8	0.9	0.9
Whole body water mass	0.6	3.3	3.8	-2.0	-1.7
Heart disease (siblings)	0.6	0.7	0.8	-0.8	-0.9
Leg fat mass (left)	0.6	2.2	2.6	-1.6	-1.3
Waist Hip Ratio (WHR)	0.5	2.1	2.3	-1.3	-1.5
Hypothyroidism (self reported)	0.5	1.1	1.2	-1.1	-1.0
Pack years adult smoking proportion	0.5	0.7	0.9	-0.9	-0.7
Serious illness, injury or assault to yourself	0.5	0.6	0.8	0.9	0.7
Fluid intelligence score	0.5	1.0	1.0	-1.0	-1.0
Trunk fat-free mass	0.5	2.8	3.2	-1.8	-1.5
Trunk predicted mass	0.5	2.7	3.2	-1.8	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.1	0.6	1.0
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	0.9	-0.9	-0.8
Migraine (self-reported)	0.5	0.7	1.0	-1.0	-0.6
Arm predicted mass (right)	0.5	2.6	3.1	-1.8	-1.4
Whole body fat-free mass	0.5	3.1	3.6	-1.9	-1.6
Leg fat-free mass (right)	0.5	2.4	2.9	-1.7	-1.4
Average weekly red wine intake	0.5	0.8	1.0	-0.8	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	0.9	0.8	0.9
Back pain experienced in last month	0.5	0.7	0.7	0.8	0.8
Leg predicted mass (right)	0.5	2.4	2.9	-1.7	-1.4
Arm fat mass (left)	0.5	2.1	2.5	-1.6	-1.3
Guilty feelings	0.5	0.7	0.9	0.8	0.9
Basal metabolic rate	0.5	3.0	3.6	-1.9	-1.5
Intelligence (Savage-Jansen 2018)	0.4	1.1	1.2	1.1	1.1
Alzheimer’s Disease (including proxy)	0.4	0.5	1.0	0.3	1.0
Primary Biliary Cirrhosis	0.4	0.5	0.6	0.7	0.8
Allergy or Eczema	0.4	1.0	1.2	1.1	0.9
Lung FVC	0.4	1.8	1.9	1.3	1.4
Pain all over the body in last month	0.4	0.4	0.4	-0.6	-0.6
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.8	-0.4	-0.9
Medication: Paracetamol	0.4	0.6	1.0	0.5	1.0
Medication: Amlodipine	0.4	0.5	0.6	-0.7	-0.7
Body fat percentage	0.4	1.5	1.8	-1.3	-1.1
Leg fat percentage (right)	0.4	1.3	1.6	-1.3	-1.0
Arm fat-free mass (right)	0.4	2.1	2.6	-1.6	-1.3
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.6	0.6	0.7
Arm fat percentage (left)	0.4	1.8	2.0	-1.4	-1.2
Friendships satisfaction	0.4	0.5	0.7	-0.6	-0.8
Ever smoked	0.4	0.7	0.7	0.8	0.9
Number of operations (self-reported)	0.4	0.5	0.6	0.7	0.8
Unable to work because of sickness or disability	0.4	0.5	0.7	-0.8	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	0.7	0.7	0.8
Pack years of smoking	0.4	0.6	0.7	-0.9	-0.7
Rheumatoid Arthritis	0.3	0.4	0.4	0.6	0.7
Diabetes (mother)	0.3	0.4	0.5	0.7	0.6
Trunk fat percentage	0.3	1.3	1.7	-1.3	-1.0
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	0.4	0.6	0.6
Had other major operations	0.3	0.4	0.5	0.4	0.7
Arm fat percentage (right)	0.3	1.3	1.5	-1.2	-1.1
Hip circumference	0.3	1.4	2.0	-1.4	-0.9
Qualifications: A levels/AS levels or equivalent	0.3	0.8	0.9	0.8	1.0
High blood pressure (siblings)	0.3	0.4	0.4	0.7	0.6
Wheeze or whistling in the chest in last year	0.3	0.5	0.9	0.9	0.4
Age at first live birth	0.3	0.5	0.6	0.6	0.8
Overall health rating	0.3	0.6	0.8	0.6	0.9
Age at last live birth	0.3	0.5	0.6	0.5	0.8
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.4	-0.6	-0.6
Medication for cholesterol	0.3	0.5	0.8	0.5	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.5	0.5	0.7
Medication: Gliclazide	0.3	0.4	0.4	-0.5	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	0.8	0.8	0.9
Wears glasses or contact lenses	0.3	0.3	0.4	-0.5	-0.6
Arm fat-free mass (left)	0.3	1.6	1.9	-1.4	-1.1
Age started oral contraceptive pill	0.3	0.3	0.4	-0.5	-0.6
Cholesterol lowering medication	0.3	0.5	0.8	0.9	0.3
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.3	0.6	0.6
Arm predicted mass (left)	0.3	1.4	1.7	-1.3	-1.1
Bipolar Disorder (2018)	0.2	0.3	0.4	0.4	0.7
Depressed Affect (Nagel 2018)	0.2	0.5	0.6	0.6	0.8
Neuroticism (Nagel 2018)	0.2	0.5	0.6	0.7	0.8
Schizophrenia (2018)	0.2	0.4	0.6	-0.8	-0.4
Bipolar Disorder (2011)	0.2	0.2	0.3	0.5	0.3
Neuroticism (2016)	0.2	0.2	0.3	-0.4	-0.5
Height	0.2	3.5	3.8	-1.7	-2.0
Systolic Blood Pressure	0.2	1.1	1.3	-1.1	-0.9
Respiratory disease	0.2	0.5	0.8	0.9	0.4
Hand grip strength (left)	0.2	0.4	0.5	-0.6	-0.7
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.3	0.6	0.4
Hand grip strength (right)	0.2	0.4	0.7	0.8	0.5
High blood pressure	0.2	0.4	0.6	0.8	0.5
Multivitamins +/- minerals	0.2	0.3	0.3	0.4	0.6
Waist circumference	0.2	0.7	0.9	-0.9	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.6	-0.8	-0.5
Qualifications: None of the above	0.2	0.3	0.5	0.7	0.4
Mouth/teeth dental problems	0.2	0.3	0.4	0.3	0.7
Illnesses of siblings	0.2	0.3	0.3	-0.6	-0.4
Neuroticism score	0.2	0.4	0.5	0.5	0.7
Worrier / anxious feelings	0.2	0.5	0.8	0.3	0.9
Depression (self-reported)	0.2	0.2	0.3	-0.6	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.0	-1.0	-0.1
Pulse wave Arterial Stiffness index	0.2	0.2	0.3	-0.6	-0.4
Blood clot in the leg (DVT)	0.2	0.3	0.4	0.4	0.6
Forced vital capacity (FVC), Best measure	0.2	0.6	1.1	-1.1	-0.2
Comparative body size at age 10	0.2	0.5	0.7	0.8	0.5
Shortness of breath walking on level ground	0.2	0.2	0.2	0.5	0.4
Medication: Ibuprofen	0.2	0.2	0.2	-0.5	-0.4
Mean time to correctly identify matches	0.2	0.4	0.4	0.6	0.6
Medication: Aspirin	0.2	0.2	0.3	0.5	0.4
Knee pain experienced in last month	0.2	0.4	0.6	-0.4	-0.8
Diabetes diagnosed by doctor	0.2	0.3	0.5	-0.5	-0.7
Mother’s age at death	0.2	0.2	0.3	0.6	0.4
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.4	0.3	0.6
Eye problems/disorders: Glaucoma	0.2	0.3	0.4	-0.6	-0.3
High cholesterol (Self-reported)	0.2	0.4	0.6	-0.4	-0.7
Alcohol drinker status: Never	0.2	0.2	0.3	0.4	0.6
Leg fat percentage (left)	0.2	0.6	0.7	-0.8	-0.7
Commuting to job workplace: Cycle	0.2	0.3	0.5	0.7	0.2
Vascular/heart problems diagnosed by doctor	0.2	0.5	0.7	-0.8	-0.5
Worry (Nagel 2018)	0.1	0.2	0.3	0.5	0.5
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.3	-0.4	-0.5
Breast Cancer	0.1	0.3	0.4	0.6	0.4
Ovarian Cancer	0.1	0.1	0.2	0.5	0.2
HbA1C	0.1	0.1	0.1	-0.3	-0.4
Blood Platelet Count	0.1	0.7	0.9	-1.0	-0.6
Blood White Count	0.1	0.8	1.0	0.7	1.0
Smoking Status	0.1	0.1	0.2	-0.5	-0.2
Lung FEV1/FVC ratio	0.1	0.4	0.5	0.6	0.7
Sensitivity / hurt feelings	0.1	0.2	0.3	0.6	0.3
Medication: Metformin	0.1	0.2	0.4	-0.1	-0.6
Average weekly fortified wine intake	0.1	0.1	0.1	0.4	0.2
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.3	-0.5	-0.2
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.2	-0.3	-0.5
Medication: Levothyroxine sodium	0.1	0.2	0.4	-0.6	-0.1
Body mass index (BMI)	0.1	0.4	0.4	-0.7	-0.5
Impedance of leg (left)	0.1	0.4	0.5	0.5	0.7
Past tobacco smoking	0.1	0.2	0.3	-0.4	-0.5
Had menopause	0.1	0.1	0.1	-0.3	-0.3
Diabetes (self-reported)	0.1	0.1	0.2	-0.2	-0.4
Medication: Simvastatin	0.1	0.2	0.4	0.0	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.2	-0.4	-0.4
Noisy workplace	0.1	0.1	0.2	-0.4	-0.3
Tense / ‘highly strung’	0.1	0.1	0.1	-0.3	-0.4
Birth weight of first child	0.1	0.1	0.2	-0.4	-0.0
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.3	0.2	0.5
Glaucoma (self-reported)	0.1	0.1	0.1	-0.4	0.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.2	-0.5	-0.2
Worry too long after embarrassment	0.1	0.2	0.2	-0.4	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.3	-0.5	-0.3
Pulse wave peak to peak time	0.1	0.1	0.1	0.4	0.3
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.5	-0.2
Medication: Blood pressure	0.1	0.1	0.2	0.4	0.3
Medication: Omeprazole	0.1	0.1	0.1	0.2	0.3
Suffer from ‘nerves’	0.1	0.2	0.2	0.4	0.5
Chest pain or discomfort	0.1	0.2	0.3	0.5	0.2
Supplements: Vitamin C	0.1	0.1	0.2	-0.5	0.0
Hypertension (Self-reported)	0.1	0.3	0.4	0.7	0.4
Illnesses of father: Heart disease	0.1	0.2	0.3	0.1	0.6
Mood swings	0.1	0.1	0.2	0.4	0.3
Loneliness, isolation	0.1	0.1	0.1	-0.4	-0.2
Osteoarthritis (self-reported)	0.1	0.1	0.2	0.3	0.4
Medication: Aspirin	0.1	0.1	0.2	0.4	0.3
Hearing aid user	0.1	0.1	0.1	-0.1	-0.3
Medication: Blood pressure	0.1	0.3	0.5	-0.3	-0.7
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.1	0.2	0.4
Irritability	0.1	0.2	0.3	0.3	0.5
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.1	0.3	0.1
Pain experienced in last month	0.1	0.2	0.2	0.3	0.5
Basal cell carcinoma (self-reported)	0.1	0.2	0.3	-0.6	0.1
Alcohol drinker status: Previous	0.1	0.1	0.2	0.4	0.2
Bipolar Disorder or Schizophrenia	0.0	0.1	0.1	-0.4	0.1
Depression (Nagel 2018)	0.0	0.0	0.1	0.1	0.3
Alzheimer’s Disease (in father)	0.0	0.0	0.0	-0.2	0.2
Prostate Cancer	0.0	0.0	0.1	0.2	0.2
Fasting Glucose	0.0	0.0	0.0	0.1	-0.1
HDL Cholesterol	0.0	0.0	0.1	-0.3	-0.1
Blood Eosinophil Count	0.0	0.0	0.1	0.2	0.2
Blood Red Count	0.0	0.0	0.0	-0.2	-0.2
Heel T-Score	0.0	0.0	0.1	0.2	0.0
BMI	0.0	0.1	0.1	-0.2	0.2
Cardiovascular Disease	0.0	0.1	0.2	-0.3	-0.4
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.0	-0.1	0.1
Neuroticism	0.0	0.1	0.1	-0.2	-0.2
Chronotype (morning person)	0.0	0.1	0.1	0.3	0.4
Hair Pigment	0.0	0.5	0.5	-0.7	-0.7
Tanning	0.0	0.1	0.1	0.1	-0.4
Number of treatments/medications taken	0.0	0.0	0.0	-0.1	0.0
Hearing difficulty/problems: Yes	0.0	0.0	0.0	0.1	-0.2
Relative age of first facial hair	0.0	0.0	0.0	0.1	-0.0
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.0	0.1	0.1
Systolic blood pressure, automated reading	0.0	0.0	0.0	0.2	0.2
Vitamin and mineral supplements	0.0	0.0	0.0	0.2	-0.2
Diabetes (father)	0.0	0.0	0.0	0.2	-0.2
Impedance of leg (right)	0.0	0.0	0.0	-0.2	0.1
Townsend deprivation index at recruitment	0.0	0.0	0.0	0.1	0.2
Current tobacco smoking	0.0	0.0	0.0	0.0	0.1
Maternal smoking around birth	0.0	0.0	0.0	0.1	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.1	0.1	0.1	0.3
Relative age voice broke	0.0	0.0	0.1	-0.0	-0.3
Nervous feelings	0.0	0.1	0.2	-0.4	0.1
Hearing difficulty/problems with background noise	0.0	0.0	0.0	0.2	-0.2
Forced vital capacity (FVC)	0.0	0.2	0.3	-0.6	-0.0
Impedance of arm (right)	0.0	0.0	0.1	-0.2	-0.0
Alcohol intake versus 10 years previously	0.0	0.0	0.0	0.1	0.1
Father’s age at death	0.0	0.0	0.0	0.1	-0.1
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.2	-0.2	0.4
Happiness	0.0	0.0	0.0	0.1	-0.1
Mouth/teeth dental problems: Dentures	0.0	0.0	0.0	0.1	0.2
Medication: Lansoprazole	0.0	0.0	0.0	0.2	-0.1
Prospective memory result	0.0	0.0	0.0	0.2	0.0
Impedance of arm (left)	0.0	0.1	0.2	-0.4	-0.2
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.0	-0.1	0.1
Headache pain in last month	0.0	0.0	0.0	0.2	-0.1
Gout (self-reported)	0.0	0.0	0.0	-0.1	-0.1
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.1	0.1	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.1	-0.1	-0.3
Medication for pain relief, constipation, heartburn	0.0	0.1	0.1	0.3	0.1
Medication: Allopurinol	0.0	0.0	0.1	-0.3	-0.1
Comparative height size at age 10	0.0	0.2	0.5	-0.7	-0.2
Leg pain on walking	0.0	0.0	0.0	0.2	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.1	-0.1	0.2
Smoking status: Previous	0.0	0.0	0.0	-0.2	-0.2
Osteoporosis (self-reported)	0.0	0.0	0.0	-0.2	0.1
Smoking status: Current	0.0	0.0	0.0	-0.0	0.2
Number of self-reported non-cancer illnesses	0.0	0.0	0.0	-0.0	0.1
Miserableness	0.0	0.0	0.1	0.0	0.3
Medication: Bendroflumethiazide	0.0	0.0	0.1	0.3	-0.1
Medication: Paracetamol	0.0	0.0	0.0	-0.1	0.2
Fractured/broken bones in last 5 years	0.0	0.0	0.0	-0.2	0.2
Diastolic blood pressure, automated reading	0.0	0.0	0.0	0.0	0.2
Ever depressed for a whole week	0.0	0.0	0.0	0.1	-0.2
Impedance of whole body	0.0	0.0	0.0	-0.0	0.2

Hub : Genes

IRGM

Models

Trait associations