TWAS hub - ZNF300

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Muscularis	0.1010	0.0430	9.8e-03	0.100	NA	0.102	NA	0.093	1.2e-06	NA	9.6e-07	NA	2.8e-06
2	GTEx	Nerve Tibial	0.1317	0.0477	3.3e-03	0.050	NA	0.068	NA	0.089	1.8e-04	NA	1.6e-05	NA	7.0e-07
3	GTEx	Testis	0.2760	0.0680	3.9e-05	0.184	NA	0.141	NA	0.180	1.4e-08	NA	8.0e-07	NA	2.1e-08
4	TCGA	Brain Lower Grade Glioma	0.0479	0.0281	3.0e-05	0.037	0.031	0.034	NA	0.034	4.3e-05	0.00015	9.5e-05	NA	9.3e-05
5	TCGA	Thyroid Carcinoma	0.0340	0.0220	4.2e-03	0.011	0.006	0.001	NA	0.005	2.8e-02	0.08100	2.4e-01	NA	1.1e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Crohns Disease (2012)	34.7	55.8	68.9	7.3	5.7	7.5	8.3	8.3
Crohns Disease (2017)	30.0	65.8	86.1	7.5	5.6	8.4	9.2	9.3
Irritable Bowel Disease (IBD)	20.6	49.0	61.8	6.9	4.5	7.7	7.9	7.6
Ulcerative Colitis (UC)	7.3	13.7	21.5	4.0	1.8	4.6	4.0	3.4
Ulcerative Colitis	5.5	8.0	11.0	3.3	1.6	3.2	3.0	2.7
Chronic bronchitis/emphysema (father)	5.3	6.3	8.8	-2.6	-0.9	-3.0	-3.0	-2.5
Lung cancer (father)	4.6	5.4	6.4	-2.2	-2.0	-2.5	-2.5	-2.3
Loud music exposure frequency	4.3	4.7	7.6	-2.3	-0.9	-2.8	-2.3	-2.1
Supplements: Zinc	3.5	3.9	6.2	-1.7	-1.1	-2.5	-2.4	-1.8
Long-standing illness, disability or infirmity	3.2	4.8	6.8	2.3	1.6	2.6	2.4	1.9
Severe depression (siblings)	3.1	3.5	6.5	-1.8	0.2	-1.4	-2.4	-2.6
Pulse rate	3.1	5.2	6.8	-2.6	-2.4	-2.2	-2.2	-1.9
Ever had bowel cancer screening	3.1	3.6	4.3	1.7	1.7	1.8	2.1	2.1
Hair/balding pattern: Pattern 2	2.9	3.7	4.1	-2.0	-1.8	-2.0	-2.0	-1.8
Heart disease (mother)	2.9	3.6	5.4	-1.4	-2.0	-1.4	-2.1	-2.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.8	3.3	4.6	1.9	1.0	2.1	2.0	1.8
Mean Putamen Volume	2.7	3.1	3.6	1.5	1.9	1.8	1.8	1.8
Average weekly spirits intake	2.7	3.4	5.0	2.1	1.4	2.2	1.9	1.5
Medication: Ventolin 100micrograms inhaler	2.6	3.4	4.3	1.9	2.1	1.5	1.9	1.8
Type 2 Diabetes (T2D) (2012)	2.3	2.7	3.4	1.5	1.8	1.2	1.9	1.8
Ever had stillbirth, spontaneous miscarriage or termination	2.3	2.5	3.4	-1.7	-1.8	-1.2	-1.7	-1.3
Medication: Co-codamol	2.2	2.6	3.4	-1.2	-1.8	-1.2	-1.8	-1.8
Commuting to job workplace: Walk	2.2	2.4	3.3	1.4	1.3	1.8	1.6	1.5
Forced expiratory volume in 1-second (FEV1), predicted	2.1	4.4	10.5	-2.3	-3.2	-1.7	-1.7	-0.7
Mineral and other dietary supplements	2.1	2.8	5.3	-1.6	-2.3	-0.8	-1.5	-1.8
Sitting height	2.0	14.4	26.7	-3.9	-5.2	-3.3	-3.5	-2.6
Time employed in main current job	2.0	2.3	4.4	1.5	2.1	0.7	1.4	1.5
Angina (self-reported)	2.0	2.7	4.4	1.3	0.5	2.1	2.0	1.8
Heart attack/myocardial infarction (self-reported)	2.0	2.6	3.6	1.1	1.5	1.9	1.9	1.5
Commuting to job workplace: Car/motor vehicle	1.9	2.2	3.6	1.7	-0.3	1.9	1.7	1.3
Qualifications: nursing, teaching	1.9	3.0	4.9	-1.3	-0.9	-2.2	-2.1	-1.7
Supplements: Fish oil (including cod liver oil)	1.9	2.5	6.7	1.6	2.6	0.8	1.1	1.2
Ever had hysterectomy (womb removed)	1.7	1.9	4.1	0.8	0.7	1.0	1.8	2.0
Angina	1.7	2.2	3.5	1.1	0.5	1.9	1.9	1.7
Heart attack	1.7	2.2	3.3	1.0	1.5	1.8	1.7	1.3
Asthma (self-reported)	1.7	3.5	4.9	1.3	1.6	1.9	2.2	2.2
Commuting to job workplace: Public transport	1.7	2.1	3.7	-1.6	-0.8	-1.9	-1.5	-1.1
Schizophrenia vs Biploar Disorder	1.6	2.1	3.0	-1.4	0.4	-1.6	-1.7	-1.7
Asthma	1.6	3.2	4.4	1.2	1.9	1.7	2.1	2.0
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	3.9	-1.7	-2.0	-1.1	-1.2	-0.8
Age when periods started (menarche)	1.5	3.7	5.8	2.1	0.4	2.4	2.0	1.9
High blood pressure (mother)	1.5	2.0	4.0	-1.0	-0.5	-2.0	-1.8	-1.3
Number of full brothers	1.5	1.9	4.3	-1.9	-2.1	-0.4	-0.9	-0.5
Medication: Seretide 50 evohaler	1.5	1.7	2.4	0.6	1.6	1.2	1.4	1.5
Bipolar Disorder (2011)	1.4	1.4	4.7	-1.1	-2.2	0.6	0.5	0.7
Pulse wave reflection index	1.4	1.7	3.5	1.1	0.4	1.9	1.6	1.0
Average weekly champagne plus white wine intake	1.4	2.0	3.0	-1.2	-0.5	-1.5	-1.7	-1.6
Financial situation satisfaction	1.4	1.7	2.4	1.3	1.4	1.6	1.3	1.0
Illnesses of father: High blood pressure	1.4	1.7	2.6	-1.3	-1.6	-1.2	-1.4	-1.0
Heart disease (siblings)	1.4	1.7	6.4	-1.2	-2.5	-0.2	-0.7	-0.6
Body Mass Index (BMI) (2010)	1.3	1.8	2.3	1.3	1.2	1.5	1.5	1.1
Schizophrenia (2014)	1.3	2.8	3.5	-1.7	-1.7	-1.9	-1.8	-1.2
Allergy	1.3	3.0	6.9	-0.8	-0.9	-1.5	-2.1	-2.6
Medication: Ramipril	1.3	1.6	2.2	1.4	0.7	1.5	1.4	1.2
Exposure to tobacco smoke at home	1.3	1.4	2.5	-0.6	-1.1	-0.8	-1.5	-1.6
Breastfed as a baby	1.3	1.6	3.3	-1.0	0.1	-1.3	-1.5	-1.8
Ever taken oral contraceptive pill	1.3	1.4	3.2	1.0	1.8	1.0	1.1	0.8
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	1.7	1.3	1.1	1.0	1.2	1.1
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	2.4	-1.2	-1.6	-1.3	-1.0	-0.2
Risk taking	1.2	1.8	5.5	-1.2	-2.3	-0.8	-1.0	-0.4
Age at First Birth	1.1	1.6	2.8	-1.7	-0.3	-1.2	-1.5	-1.3
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	2.2	0.9	-0.1	1.4	1.5	1.2
Hair/balding pattern: Pattern 4	1.1	2.7	3.5	1.9	1.8	1.5	1.5	1.4
Eye problems/disorders: None of the above	1.1	1.3	1.6	1.2	0.7	1.2	1.3	1.1
Illnesses of father: None of the above (group 1)	1.1	1.3	1.9	1.1	1.4	1.2	1.2	1.0
Supplements: Calcium	1.1	1.2	1.9	-1.3	-0.8	-1.4	-1.0	-0.7
Major Depression (MDD)	1.0	1.2	1.9	0.4	-0.8	1.4	1.2	1.3
Pack years adult smoking proportion	1.0	1.5	3.4	-1.0	-1.8	-1.0	-1.1	-1.0
Taking other prescription medications	1.0	1.6	2.7	-1.6	-0.9	-1.0	-1.3	-1.3
Medication: Atenolol	1.0	1.2	1.7	1.3	1.1	1.1	1.1	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.1	2.2	0.5	-0.2	1.2	1.3	1.5
Medication: Lisinopril	1.0	1.3	1.8	-1.0	-1.1	-1.1	-1.3	-1.2
Myopia	1.0	1.5	2.2	-1.4	-0.7	-1.5	-1.2	-1.1
Ever used hormone-replacement therapy (HRT)	0.9	1.2	2.0	-0.8	-0.6	-1.1	-1.4	-1.3
Hayfever, allergic rhinitis or eczema	0.9	1.9	5.0	0.5	0.8	0.9	1.6	2.2
Pulse wave Arterial Stiffness index	0.9	1.0	1.6	-1.3	-1.2	-0.4	-0.8	-1.2
Length of working week for main job	0.9	1.0	1.9	-1.1	-1.4	-1.0	-0.9	-0.5
Peak expiratory flow (PEF)	0.9	2.1	4.5	0.8	0.7	1.6	1.5	2.1
Pulse rate, automated reading	0.9	3.0	4.4	-2.1	-1.1	-2.1	-1.7	-1.3
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	3.2	-0.0	-1.2	0.9	1.2	1.8
Ever had prostate specific antigen (PSA) test	0.9	1.1	4.5	0.8	2.1	0.2	0.3	0.2
Pack years of smoking	0.9	1.3	2.5	-0.8	-1.6	-1.0	-1.1	-1.1
Diabetes (mother)	0.8	1.0	1.7	1.1	1.3	0.7	0.9	0.8
Leg fat-free mass (left)	0.8	4.0	5.6	-1.8	-2.4	-1.8	-2.2	-1.8
Leg predicted mass (left)	0.8	4.3	6.2	-1.8	-2.5	-1.8	-2.3	-1.8
Standing height	0.8	7.7	13.9	-2.7	-3.7	-2.4	-2.7	-2.1
Alcohol intake frequency.	0.8	1.9	2.9	-1.1	-0.2	-1.6	-1.6	-1.7
Had major operations	0.8	0.9	1.7	1.1	0.4	1.3	1.0	0.9
Illnesses of siblings: Diabetes	0.8	1.0	1.6	1.2	0.9	1.3	0.8	0.5
Coronary Artery Disease (CAD)	0.7	0.8	1.2	1.1	-0.2	0.9	1.0	0.9
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	2.0	1.1	1.4	0.4	0.5	0.3
Supplements: Glucosamine	0.7	0.9	1.7	0.3	0.1	1.0	1.3	1.3
Number of incorrect matches in round	0.7	1.1	2.2	-1.0	-0.2	-1.5	-1.2	-1.0
Financial difficulties in last 2 years	0.7	1.0	2.2	0.5	0.2	1.1	1.1	1.5
Number of live births	0.7	1.0	1.4	1.2	-0.2	1.2	0.9	1.2
Pulse wave peak to peak time	0.7	0.8	1.2	1.1	1.1	0.2	0.7	1.0
Health satisfaction	0.7	1.0	1.7	-1.0	-1.0	-0.3	-1.0	-1.3
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.5	-0.6	-0.4	-0.8	-1.1	-1.2
Neck or shoulder pain in last month	0.7	1.0	2.0	-1.4	-0.5	-1.3	-1.0	-0.4
Commuting to job workplace: Cycle	0.7	0.8	3.0	0.1	1.7	0.6	0.7	0.4
Bipolar Disorder (2018)	0.6	1.0	2.6	-0.6	-1.1	0.1	0.7	1.6
HbA1C	0.6	0.7	1.9	0.3	-0.0	-0.6	-1.4	-1.0
Primary Biliary Cirrhosis	0.6	0.9	2.5	-0.2	-1.6	0.6	0.8	0.9
Allergy or Eczema	0.6	1.6	3.9	0.6	0.9	1.0	1.4	2.0
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	1.8	-0.8	-1.3	-1.3	-1.3	-0.9
Multivitamins +/- minerals	0.6	0.8	2.1	1.1	1.5	0.4	0.5	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	1.8	0.5	-0.3	1.3	1.2	1.1
Qualifications: None of the above	0.6	1.2	2.8	0.3	1.7	0.8	1.0	1.3
Father’s age at death	0.6	0.8	3.0	0.8	1.7	-0.4	0.1	-0.0
Falls in the last year	0.6	0.8	1.4	0.5	0.3	1.0	1.0	1.2
Hair/balding pattern: Pattern 3	0.6	1.0	1.9	1.0	0.6	1.4	1.1	0.5
Medication: Cholesterol lowering	0.6	0.9	1.3	-1.1	-0.0	-0.9	-1.1	-1.0
Depression (self-reported)	0.6	0.7	2.1	-0.9	-1.4	-0.3	-0.5	-0.4
Birth weight	0.6	1.3	2.3	0.7	0.7	1.5	1.4	1.2
Number of children fathered	0.6	0.7	1.8	-0.8	-0.1	-1.3	-0.9	-0.2
Qualifications: College or University degree	0.6	1.9	2.1	-1.4	-1.4	-1.4	-1.4	-1.3
Whole body fat mass	0.6	2.4	3.7	-1.1	-1.6	-1.5	-1.9	-1.5
Whole body fat-free mass	0.6	3.2	5.1	-1.7	-2.3	-1.6	-1.9	-1.3
Eye problems/disorders: Cataract	0.6	0.7	1.1	-1.0	-0.5	-0.9	-0.9	-0.7
Whole body water mass	0.6	3.2	4.7	-1.8	-2.2	-1.6	-1.9	-1.4
Mother’s age at death	0.6	0.7	1.6	1.3	1.2	0.6	0.5	0.2
Medication: Atorvastatin	0.6	0.7	0.9	-0.8	-0.9	-0.8	-0.9	-0.8
Basal metabolic rate	0.6	3.2	5.8	-1.7	-2.4	-1.6	-1.8	-1.3
Age started oral contraceptive pill	0.6	0.7	1.8	0.0	1.3	-0.6	-0.6	-1.0
Basal cell carcinoma (self-reported)	0.6	0.7	1.3	-1.1	-1.2	-0.6	-0.5	-0.2
Alzheimer’s Disease (including proxy)	0.5	0.8	3.5	-0.2	-1.9	0.1	0.4	0.5
LDL Cholesterol	0.5	0.7	1.3	1.0	0.6	1.1	0.8	0.6
Lupus	0.5	0.8	1.7	0.6	-1.3	1.1	0.6	0.7
Triglycerides	0.5	0.8	1.9	0.7	0.4	1.4	1.0	0.8
Fed-up feelings	0.5	0.9	2.6	0.7	0.1	1.6	1.0	0.7
Qualifications: CSEs or equivalent	0.5	0.6	1.0	0.9	0.1	0.5	0.9	1.0
High blood pressure	0.5	1.3	2.7	1.6	1.4	0.7	0.8	0.8
Trunk fat mass	0.5	2.1	3.6	-0.9	-1.4	-1.6	-1.9	-1.4
Fluid intelligence score	0.5	1.0	1.9	-0.9	-0.1	-0.8	-1.2	-1.4
Weight	0.5	2.6	3.7	-1.3	-1.9	-1.5	-1.9	-1.4
Trunk fat-free mass	0.5	2.7	4.1	-1.8	-2.0	-1.6	-1.7	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.6	-0.8	-1.6	0.3	-0.7	-0.7
Qualifications: A levels/AS levels or equivalent	0.5	1.0	2.3	0.3	-0.5	1.1	1.1	1.5
Trunk predicted mass	0.5	2.7	4.4	-1.7	-2.1	-1.5	-1.6	-1.1
Comparative body size at age 10	0.5	1.4	2.6	0.9	1.6	0.9	1.1	1.2
Wheeze or whistling in the chest in last year	0.5	0.9	2.2	0.6	0.3	0.6	1.2	1.5
Leg fat mass (right)	0.5	2.0	3.3	-1.0	-1.4	-1.5	-1.8	-1.3
Number of full sisters	0.5	0.6	1.6	0.7	-0.5	1.3	0.7	0.3
Family relationship satisfaction	0.5	0.6	1.6	-0.1	-0.1	0.7	1.0	1.3
Leg fat-free mass (right)	0.5	2.7	4.5	-1.4	-2.1	-1.3	-1.8	-1.4
Back pain experienced in last month	0.5	0.7	1.4	0.4	-0.8	1.2	0.8	0.8
Breast cancer (self-reported)	0.5	0.6	1.1	1.0	0.9	0.5	0.8	0.6
Leg predicted mass (right)	0.5	2.7	4.4	-1.4	-2.1	-1.3	-1.8	-1.4
Arm fat mass (left)	0.5	1.9	3.0	-0.9	-1.4	-1.4	-1.7	-1.4
Wears glasses or contact lenses	0.5	0.6	1.6	-0.4	0.5	-0.7	-0.8	-1.3
Average weekly beer plus cider intake	0.5	0.7	1.1	0.6	0.6	1.0	0.9	0.8
Unable to work because of sickness or disability	0.5	0.6	1.1	-0.7	-0.6	-0.6	-0.9	-1.1
Vascular/heart problems diagnosed by doctor	0.5	1.3	2.1	-1.5	-1.4	-0.7	-0.9	-1.0
Alzheimer’s Disease (in mother)	0.4	0.4	1.4	-0.1	-1.2	0.2	0.6	0.7
Waist Hip Ratio (WHR)	0.4	1.6	2.3	-1.3	-0.3	-1.4	-1.4	-1.5
Hypothyroidism (self reported)	0.4	0.8	1.1	-1.0	-0.6	-0.9	-1.1	-0.9
Respiratory disease	0.4	0.8	2.8	0.3	1.7	0.4	0.8	0.6
Medication for hormone replacement therapy	0.4	0.5	0.7	-0.1	0.8	-0.9	-0.8	-0.6
Stomach or abdominal pain in last month	0.4	0.5	1.2	0.3	0.5	1.1	0.9	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.3	-0.7	-1.5	-0.8	-0.8	-0.7
Arm fat mass (right)	0.4	1.8	2.9	-1.0	-1.3	-1.4	-1.7	-1.3
Ever highly irritable/argumentative for 2 days	0.4	0.5	2.3	0.3	1.5	-0.0	-0.0	-0.3
Arm fat-free mass (right)	0.4	2.2	4.0	-1.3	-2.0	-1.4	-1.5	-0.9
Exposure to tobacco smoke outside home	0.4	0.5	0.8	-0.6	-0.7	-0.6	-0.9	-0.6
Medication: Blood pressure	0.4	0.6	1.2	0.9	1.1	0.8	0.5	0.6
Medication: Ibuprofen	0.4	0.5	1.3	-0.7	-1.2	-0.4	-0.5	-0.3
Arm predicted mass (right)	0.4	2.3	3.7	-1.3	-1.9	-1.4	-1.7	-1.0
Chest pain or discomfort	0.4	0.6	1.0	-0.2	-0.8	0.9	0.6	1.0
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.7	-0.0	-1.3	-0.0	0.1	0.7
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.7	0.6	1.3	0.5	0.4	-0.1
Hypertension (Self-reported)	0.4	1.1	2.5	1.6	1.4	0.7	0.6	0.6
Friendships satisfaction	0.4	0.5	1.5	-1.2	-0.8	-0.3	-0.4	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.9	0.3	-0.3	0.8	0.7	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.4	0.6	1.2	0.7	0.8	1.0
Guilty feelings	0.4	0.7	1.2	0.8	0.4	1.1	0.8	0.8
Medication: Bendroflumethiazide	0.4	0.7	2.6	0.8	1.6	0.3	0.2	-0.1
Arm fat-free mass (left)	0.4	1.9	3.6	-1.2	-1.9	-1.2	-1.4	-0.9
Number of operations (self-reported)	0.4	0.6	1.4	0.3	0.5	1.2	0.7	0.9
Cholesterol lowering medication	0.4	0.5	1.1	0.8	0.3	1.1	0.8	0.4
Leg fat mass (left)	0.4	1.5	2.7	-0.7	-1.1	-1.4	-1.6	-1.2
Depressed Affect (Nagel 2018)	0.3	0.6	1.6	0.4	0.1	1.3	0.7	0.7
Reaction Time	0.3	0.6	1.2	0.2	-0.0	0.8	1.0	1.1
Rheumatoid Arthritis	0.3	0.4	0.7	0.7	-0.0	0.9	0.7	0.6
Lung FVC	0.3	1.3	2.7	0.1	-1.4	1.6	1.1	0.7
Sensitivity / hurt feelings	0.3	0.6	1.6	0.1	0.1	1.2	0.6	0.9
Relative age of first facial hair	0.3	0.6	2.7	0.4	1.6	-0.2	0.0	-0.5
Vitamin and mineral supplements	0.3	0.4	1.8	0.0	-1.4	0.1	-0.2	-0.5
Trunk fat percentage	0.3	1.1	2.1	-0.4	-1.0	-1.2	-1.4	-1.0
Hand grip strength (right)	0.3	0.8	1.5	0.6	1.2	0.5	1.0	1.0
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.6	-0.5	-0.7	-0.7	-0.4	-0.4
Serious illness, injury or assault to yourself	0.3	0.4	0.9	0.6	0.5	1.0	0.7	0.1
Had menopause	0.3	0.3	0.8	0.5	0.9	-0.1	-0.4	-0.7
Forced vital capacity (FVC)	0.3	1.0	3.1	-1.3	-1.7	-0.3	-0.3	0.4
Mouth/teeth dental problems	0.3	0.5	1.8	0.7	1.3	-0.1	0.4	0.1
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.8	-0.9	0.1	-0.9	-0.3	0.2
Neuroticism score	0.3	0.5	1.2	0.3	0.1	1.1	0.8	0.9
Arm fat percentage (right)	0.3	1.1	1.7	-0.6	-0.9	-1.1	-1.3	-1.1
Hip circumference	0.3	1.1	2.0	-0.6	-1.4	-1.1	-1.3	-0.7
Prospective memory result	0.3	0.4	0.9	-0.5	-0.4	0.7	0.6	0.9
Illnesses of mother	0.3	0.4	0.9	0.1	-0.1	0.9	0.9	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.6	0.3	-0.7	0.6	0.7	0.8
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.2	-0.8	-1.1	-0.6	-0.6	-0.2
High blood pressure (siblings)	0.3	0.5	1.1	0.0	-0.3	1.1	0.7	0.8
Forced vital capacity (FVC), Best measure	0.3	1.1	2.1	-1.5	-1.3	-0.9	-0.9	-0.2
Body fat percentage	0.3	1.2	2.1	-0.5	-0.9	-1.2	-1.5	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.0	-0.8	-1.0	0.0	-0.4	-0.3
Migraine (self-reported)	0.3	0.3	0.6	-0.4	-0.6	-0.8	-0.7	-0.3
Medication: Omeprazole	0.3	0.4	1.5	-0.2	-1.2	0.2	0.2	0.4
Medication: Aspirin	0.3	0.4	1.0	1.0	0.5	0.7	0.5	0.4
Arm fat percentage (left)	0.3	1.4	2.4	-0.7	-1.0	-1.2	-1.5	-1.3
Average weekly red wine intake	0.3	0.5	1.3	-1.1	-0.7	-0.4	-0.6	-0.2
Mood swings	0.3	0.6	1.5	0.2	-1.2	0.9	0.5	0.5
Medication: Gliclazide	0.3	0.4	1.4	-0.1	1.2	-0.5	-0.3	-0.2
Miserableness	0.3	0.6	2.1	-0.5	-1.4	0.6	0.2	0.5
Eye problems/disorders: Glaucoma	0.3	0.3	0.6	-0.4	-0.5	-0.8	-0.5	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.6	0.4	-0.5	0.6	0.6	0.8
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.5	0.7	-0.4	0.7	0.6	0.6
Alcohol drinker status: Previous	0.3	0.3	0.6	0.7	-0.2	0.8	0.5	0.5
Arm predicted mass (left)	0.3	1.6	3.3	-1.0	-1.8	-1.2	-1.3	-0.8
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.3	0.7	0.1	1.1	0.9	0.4
Neuroticism (Nagel 2018)	0.2	0.5	1.8	0.2	-0.0	1.3	0.5	0.6
Schizophrenia (2018)	0.2	0.3	0.6	-0.4	-0.2	-0.7	-0.7	-0.6
Alzheimer’s Disease (in father)	0.2	0.2	1.1	0.2	-1.0	-0.0	-0.1	0.1
Ovarian Cancer	0.2	0.3	0.9	0.0	-0.6	0.9	0.2	0.3
Blood White Count	0.2	1.6	3.9	1.4	2.0	1.2	0.7	0.4
Height	0.2	3.9	5.7	-1.8	-2.4	-1.6	-2.0	-2.0
Systolic Blood Pressure	0.2	1.0	1.2	-1.0	-0.8	-1.0	-1.1	-1.0
Lung FEV1/FVC ratio	0.2	1.0	3.0	0.8	0.5	1.7	0.7	0.8
Chronotype (morning person)	0.2	0.4	0.9	0.8	0.9	0.4	0.4	0.1
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.0	0.3	0.2	1.0	0.5	0.4
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.5	-0.4	-0.7	0.4	-0.3	-0.6
Diabetes (father)	0.2	0.3	0.9	0.4	0.9	0.2	-0.2	-0.6
Townsend deprivation index at recruitment	0.2	0.3	1.0	0.3	1.0	0.1	-0.3	-0.7
Average weekly fortified wine intake	0.2	0.3	0.8	-0.0	-0.3	0.9	0.4	0.6
Medication: Levothyroxine sodium	0.2	0.4	0.5	-0.7	0.4	-0.5	-0.6	-0.7
Alcohol usually taken with meals	0.2	0.3	0.6	-0.3	0.3	-0.8	-0.8	-0.3
Nervous feelings	0.2	0.3	0.5	-0.6	-0.7	-0.5	-0.5	-0.5
Hearing difficulty/problems with background noise	0.2	0.2	0.7	0.7	0.8	0.2	0.2	0.0
Had other major operations	0.2	0.2	0.6	0.6	-0.2	0.8	0.1	-0.3
Pain all over the body in last month	0.2	0.3	0.5	-0.6	-0.2	-0.2	-0.7	-0.6
Illnesses of siblings	0.2	0.3	0.8	-0.1	0.1	-0.9	-0.7	-0.6
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	2.2	-0.8	-1.5	0.3	0.0	0.7
Happiness	0.2	0.2	0.6	-0.8	-0.6	0.1	-0.0	-0.2
Mouth/teeth dental problems: Dentures	0.2	0.3	0.9	-0.5	-1.0	0.4	-0.0	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.8	1.6	-1.2	-1.1	-0.6	-0.8	-0.1
Birth weight of first child	0.2	0.3	0.6	-0.4	-0.8	-0.3	-0.5	-0.7
Blood clot in the leg (DVT)	0.2	0.2	0.3	0.5	-0.5	0.5	0.4	0.4
Headache pain in last month	0.2	0.3	0.6	-0.2	-0.8	0.6	0.5	0.5
Glaucoma (self-reported)	0.2	0.3	0.7	-0.3	-0.8	-0.5	-0.2	-0.4
Medication: Amlodipine	0.2	0.3	0.3	-0.4	0.5	-0.6	-0.6	-0.5
Leg fat percentage (right)	0.2	0.9	1.5	-0.7	-0.7	-1.2	-1.2	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.7	-0.8	-0.8	-0.2	-0.2	0.4
Emphysema/chronic bronchitis	0.2	0.3	0.6	-0.7	0.2	-0.8	-0.2	0.3
Supplements: Vitamin C	0.2	0.2	0.6	-0.8	0.2	-0.4	0.0	0.5
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.7	-0.8	-0.2	-0.2	-0.4	-0.3
Medication for cholesterol	0.2	0.3	0.7	0.2	-0.4	0.8	0.5	0.5
Osteoarthritis (self-reported)	0.2	0.3	0.7	0.2	-0.6	0.4	0.6	0.8
Medication: Aspirin	0.2	0.3	0.6	0.7	-0.1	0.8	0.4	0.3
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.4	0.6	0.2	0.6	0.4	0.3
Ever smoked	0.2	0.3	0.7	0.6	0.4	0.9	0.6	0.2
Irritability	0.2	0.3	0.8	0.1	-0.2	0.7	0.6	0.9
Bipolar Disorder or Schizophrenia	0.1	0.3	0.8	-0.4	-0.9	-0.5	-0.1	0.5
Depression (Nagel 2018)	0.1	0.1	0.5	-0.1	-0.0	0.7	0.1	0.1
Worry (Nagel 2018)	0.1	0.2	0.6	0.3	0.4	0.8	0.3	0.3
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.3	-0.4	0.1	-0.3	-0.4	-0.6
Breast Cancer	0.1	0.3	0.5	0.7	0.1	0.4	0.5	0.7
Prostate Cancer	0.1	0.1	0.2	0.3	0.2	0.4	0.0	-0.2
Fasting Glucose	0.1	0.1	0.3	0.5	-0.0	0.2	-0.1	-0.3
Neuroticism (2016)	0.1	0.2	0.4	-0.2	-0.5	0.1	-0.6	-0.5
Blood Eosinophil Count	0.1	0.4	0.7	0.4	0.8	0.6	0.6	0.8
Blood Platelet Count	0.1	0.6	0.8	-0.9	0.8	-0.8	-0.8	-0.5
Smoking Status	0.1	0.2	0.5	-0.5	-0.2	-0.1	-0.6	-0.7
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.7	-0.3	-0.9	-0.1	-0.0	0.1
Hand grip strength (left)	0.1	0.4	0.9	-0.9	0.4	-0.8	-0.3	0.1
Hearing difficulty/problems: Yes	0.1	0.2	0.4	0.5	0.6	0.4	0.2	0.4
Maternal smoking around birth	0.1	0.1	0.3	0.6	-0.6	0.0	0.1	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.4	-0.1	-0.2	0.6	0.1	0.1
Relative age voice broke	0.1	0.2	0.7	-0.1	0.8	0.2	0.0	-0.4
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.1	0.0	0.3	-0.4	-0.3	-0.4
Impedance of leg (left)	0.1	0.3	0.9	0.3	-0.4	0.2	0.7	1.0
Waist circumference	0.1	0.4	0.8	-0.3	-0.5	-0.7	-0.9	-0.7
Medication: Simvastatin	0.1	0.1	0.4	-0.1	0.7	0.2	-0.1	-0.5
Alcohol intake versus 10 years previously	0.1	0.2	0.5	0.4	0.7	0.1	-0.2	-0.5
Worrier / anxious feelings	0.1	0.2	0.4	0.6	0.1	0.6	0.3	0.4
Noisy workplace	0.1	0.1	0.2	-0.3	-0.4	-0.4	-0.4	-0.3
Medication: Lansoprazole	0.1	0.1	0.6	0.2	0.8	0.3	0.1	-0.1
Impedance of arm (left)	0.1	0.3	0.6	-0.4	-0.8	-0.4	-0.5	-0.7
Tense / ‘highly strung’	0.1	0.2	0.5	-0.7	-0.4	0.2	-0.3	-0.3
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.3	-0.4	-0.2	-0.2	-0.5	-0.4
Medication: Paracetamol	0.1	0.2	0.6	0.8	0.1	0.6	0.3	0.2
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.2	0.3	-0.3	-0.3	-0.2	-0.5
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.5	-0.4	0.1	-0.3	-0.6	-0.7
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.3	0.5	0.3	-0.2	-0.2	-0.5
Worry too long after embarrassment	0.1	0.1	0.3	-0.2	0.4	-0.2	-0.4	-0.5
Age at first live birth	0.1	0.2	0.5	0.3	0.1	0.4	0.7	0.6
Shortness of breath walking on level ground	0.1	0.1	0.2	0.5	0.1	0.3	0.3	0.1
Mean time to correctly identify matches	0.1	0.2	0.5	0.1	-0.0	0.4	0.7	0.6
Comparative height size at age 10	0.1	0.3	0.6	-0.8	-0.7	-0.5	-0.5	0.0
Suffer from ‘nerves’	0.1	0.2	0.5	0.3	0.4	0.7	0.5	0.2
Overall health rating	0.1	0.3	0.6	0.6	0.1	0.7	0.5	0.6
Age at last live birth	0.1	0.1	0.2	0.2	-0.4	0.5	0.5	0.3
Knee pain experienced in last month	0.1	0.2	0.4	-0.3	-0.1	-0.6	-0.4	-0.7
Illnesses of father: Heart disease	0.1	0.1	0.3	0.1	-0.5	0.1	0.4	0.5
Smoking status: Previous	0.1	0.1	0.3	-0.5	0.2	-0.2	-0.3	-0.5
Loneliness, isolation	0.1	0.1	0.3	-0.5	-0.5	0.2	-0.2	-0.0
Diabetes diagnosed by doctor	0.1	0.1	0.2	-0.4	-0.2	-0.5	-0.2	-0.0
Osteoporosis (self-reported)	0.1	0.2	0.5	-0.3	0.4	-0.7	0.0	0.2
Hearing aid user	0.1	0.1	0.4	-0.6	-0.1	0.5	0.0	0.1
Medication: Blood pressure	0.1	0.1	0.2	0.4	0.3	-0.5	-0.2	-0.2
High cholesterol (Self-reported)	0.1	0.1	0.2	-0.3	0.4	-0.2	-0.4	-0.4
Medication: Paracetamol	0.1	0.2	0.5	0.4	-0.2	0.2	-0.4	-0.7
Alcohol drinker status: Never	0.1	0.1	0.2	0.4	0.3	0.1	0.3	0.1
Leg fat percentage (left)	0.1	0.3	0.7	-0.2	-0.3	-0.7	-0.8	-0.5
Fractured/broken bones in last 5 years	0.1	0.1	0.1	-0.3	-0.4	-0.3	-0.3	-0.3
Ever depressed for a whole week	0.1	0.1	0.5	-0.1	0.7	-0.0	0.4	0.3
Pain experienced in last month	0.1	0.2	0.4	0.5	0.6	0.2	0.2	0.2
HDL Cholesterol	0.0	0.0	0.2	0.1	0.0	-0.4	-0.1	-0.0
Blood Red Count	0.0	0.1	0.5	0.1	0.7	-0.1	-0.0	0.3
Heel T-Score	0.0	0.3	0.8	0.6	0.9	0.1	-0.2	-0.6
BMI	0.0	0.1	0.2	0.4	0.2	0.0	0.0	0.5
Cardiovascular Disease	0.0	0.0	0.1	-0.2	-0.1	-0.3	-0.3	-0.1
Neuroticism	0.0	0.1	0.3	-0.2	0.2	0.5	-0.0	0.0
Hair Pigment	0.0	0.3	0.7	-0.1	-0.5	-0.8	-0.7	-0.5
Tanning	0.0	0.1	0.2	0.2	0.1	0.1	-0.2	-0.5
Number of treatments/medications taken	0.0	0.0	0.2	-0.1	0.4	-0.0	-0.0	0.2
Systolic blood pressure, automated reading	0.0	0.1	0.1	0.1	0.3	0.3	-0.0	-0.3
Medication: Metformin	0.0	0.0	0.0	-0.0	-0.1	0.1	-0.1	-0.2
Impedance of leg (right)	0.0	0.2	0.6	-0.4	-0.8	-0.5	0.0	0.3
Current tobacco smoking	0.0	0.0	0.0	0.1	0.0	0.2	-0.1	-0.0
Body mass index (BMI)	0.0	0.2	0.5	-0.0	-0.3	-0.4	-0.7	-0.5
Past tobacco smoking	0.0	0.1	0.2	-0.1	-0.2	-0.4	-0.3	0.0
Diabetes (self-reported)	0.0	0.0	0.1	-0.2	-0.3	-0.1	-0.1	0.0
Impedance of arm (right)	0.0	0.2	0.4	-0.4	-0.6	-0.3	-0.2	-0.3
Gout (self-reported)	0.0	0.0	0.1	0.0	-0.3	-0.1	0.0	0.0
Medication for pain relief, constipation, heartburn	0.0	0.1	0.2	0.2	0.5	0.0	0.3	0.0
Medication: Allopurinol	0.0	0.0	0.0	-0.2	-0.1	-0.2	-0.2	-0.1
Leg pain on walking	0.0	0.0	0.1	0.3	-0.1	-0.1	0.1	-0.1
Smoking status: Current	0.0	0.0	0.0	0.0	-0.1	0.2	-0.1	-0.1
Number of self-reported non-cancer illnesses	0.0	0.1	0.1	-0.2	0.4	0.0	0.2	0.3
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.1	-0.0	0.4	0.1	0.1	0.1
Diastolic blood pressure, automated reading	0.0	0.2	0.3	-0.2	-0.6	-0.0	0.2	0.6
Impedance of whole body	0.0	0.1	0.6	-0.2	-0.7	-0.2	-0.1	-0.0

Hub : Genes

ZNF300

Models

Trait associations