Best TWAS P=7.14e-13 · Best GWAS P=3.42e-19 conditioned to 7.18e-11
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ADO | 0.04 | 0.01 | blup | 465 | 0.02 | 1.8e-03 | 6.4 | 5.9 | 3.4e-09 | 0.52 | 0.02 | 0.84 | FALSE |
| 2 | GTEx | Muscle Skeletal | ADO | 0.15 | 0.16 | lasso | 8 | 0.16 | 1.1e-15 | 7.0 | 7.2 | 7.1e-13 | 0.43 | 1.00 | 0.00 | TRUE |
| 3 | GTEx | Testis | ADO | 0.21 | 0.23 | lasso | 7 | 0.22 | 6.6e-10 | 7.0 | -7.1 | 1.8e-12 | -0.40 | 0.92 | 0.08 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ADO | 0.03 | 0.02 | blup | 53 | 0.03 | 1.8e-06 | 4.6 | 5.4 | 7.4e-08 | 0.29 | 0.28 | 0.71 | FALSE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ADO | 0.07 | 0.06 | blup | 53 | 0.05 | 2.5e-06 | 6.4 | 6.3 | 2.5e-10 | 0.39 | 0.00 | 1.00 | FALSE |
| 6 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | EGR2 | 0.12 | 0.10 | blup | 56 | 0.10 | 1.4e-03 | 4.7 | 5.7 | 1.4e-08 | 0.37 | 0.03 | 0.14 | FALSE |