TWAS hub - ZMIZ1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.3560	0.0640	3.4e-08	0.256	NA	0.279	NA	0.140	3.0e-17	NA	6.8e-19	NA	1.3e-09
2	YFS	Blood	0.0244	0.0102	8.0e-03	0.017	0.002	0.005	0.004	0.016	2.5e-06	0.052	6.4e-03	0.0099	4.8e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Crohns Disease (2017)	14.0	30.8	61.1	-0.7	-7.8
Irritable Bowel Disease (IBD)	9.3	22.2	43.4	-1.0	-6.6
Crohns Disease (2012)	7.0	11.3	22.4	-0.5	-4.7
Heart disease (mother)	5.5	6.7	9.1	3.0	2.1
Mouth/teeth dental problems: Mouth ulcers	5.0	7.9	13.7	-1.5	-3.7
Hypothyroidism (self reported)	4.7	10.7	20.5	1.0	4.5
Hypothyroidism/myxoedema (self-reported)	4.6	8.9	17.1	0.8	4.1
Loneliness, isolation	4.5	6.1	8.6	-2.9	1.9
Waist Hip Ratio (WHR)	4.0	18.0	29.4	5.4	2.6
Medication: Levothyroxine sodium	4.0	6.7	12.8	0.8	3.6
Illnesses of father: High blood pressure	3.9	4.8	7.5	1.4	2.7
Age at First Birth	3.5	5.1	10.2	-0.3	-3.2
Body Mass Index (BMI) (2010)	3.5	4.8	9.7	-0.1	3.1
Illnesses of mother	3.5	4.4	8.6	-2.9	-0.3
Primary Biliary Cirrhosis	3.3	4.7	7.9	1.2	2.8
Other serious medical condition/disability diagnosed by doctor	3.3	4.3	8.4	0.3	2.9
Had other major operations	3.3	4.0	4.8	-2.2	1.8
Heart disease (siblings)	3.2	3.9	3.9	2.0	2.0
Ulcerative Colitis	3.1	4.6	4.8	-2.2	-2.1
Basal cell carcinoma (self-reported)	3.1	3.7	7.3	-0.3	-2.7
Pulse rate	3.0	5.1	9.7	-3.1	-0.6
Medication: Ramipril	2.9	3.7	6.6	2.6	0.9
Medication for cholesterol	2.8	4.3	7.2	-1.2	-2.7
Fractured/broken bones in last 5 years	2.8	3.6	7.0	-0.5	2.6
Number of treatments/medications taken	2.7	4.9	6.7	1.8	2.6
Ever had hysterectomy (womb removed)	2.7	3.1	5.1	-1.0	2.2
Waist circumference	2.7	9.7	18.0	1.2	4.2
Falls in the last year	2.7	3.7	7.1	0.6	2.7
Number of full brothers	2.7	3.4	6.2	-0.8	2.5
Medication: Atorvastatin	2.7	3.3	6.7	2.6	-0.1
Qualifications: NVQ or HND or HNC or equivalent	2.6	3.1	5.4	-0.9	2.3
Illnesses of father: None of the above (group 1)	2.6	3.3	5.0	-2.2	-1.2
Eye problems/disorders: Cataract	2.5	2.9	5.5	0.6	2.4
Pack years of smoking	2.5	3.7	7.1	-0.6	2.7
Number of self-reported non-cancer illnesses	2.4	4.2	8.3	-0.1	2.9
Wheeze or whistling in the chest in last year	2.3	4.1	6.6	2.6	1.2
Illnesses of siblings: Diabetes	2.3	2.9	3.1	-1.6	1.8
Cholesterol lowering medication	2.3	3.3	6.7	-0.2	2.6
Pack years adult smoking proportion	2.2	3.4	6.2	-0.8	2.5
Tinnitus: Yes, but not now, but have in the past	2.2	2.3	2.8	1.7	1.4
Relative age voice broke	2.1	3.2	5.3	-2.3	-1.0
Depression (self-reported)	2.1	2.5	3.9	-2.0	1.0
Shortness of breath walking on level ground	2.1	2.5	4.8	-2.2	-0.6
Lung FVC	2.0	10.2	12.2	-2.8	-3.5
Impedance of arm (left)	2.0	9.2	15.3	1.7	-3.9
Average weekly beer plus cider intake	2.0	2.9	5.5	-0.6	2.3
Rheumatoid Arthritis	1.9	2.6	4.2	-1.0	2.1
Medication: Lansoprazole	1.9	2.2	3.1	1.1	1.8
Eye problems/disorders: None of the above	1.9	2.2	3.5	-0.9	-1.9
Medication: Allopurinol	1.9	2.6	4.6	-2.1	0.8
Leg fat mass (right)	1.9	7.2	14.3	0.3	3.8
Had major operations	1.9	2.2	2.6	1.6	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.9	2.2	4.0	-0.6	2.0
Arm predicted mass (left)	1.9	9.4	18.5	-0.6	4.3
Ulcerative Colitis (UC)	1.8	3.4	5.8	-1.0	-2.4
Serious illness, injury or assault to yourself	1.8	2.1	4.2	0.2	2.1
Arm predicted mass (right)	1.8	9.0	17.9	-0.4	4.2
Medication: Aspirin	1.8	2.4	3.1	1.3	1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	3.0	1.1	1.7
Arm fat-free mass (left)	1.8	8.9	17.7	-0.3	4.2
Supplements: Calcium	1.8	2.0	3.5	-1.9	0.8
Impedance of whole body	1.8	9.2	17.2	1.1	-4.1
Leg fat mass (left)	1.8	7.1	14.1	0.3	3.8
Sensitivity / hurt feelings	1.7	3.0	4.5	1.2	2.1
Alcohol usually taken with meals	1.7	2.8	5.6	0.1	-2.4
Impedance of arm (right)	1.7	8.0	12.8	1.8	-3.6
Trunk fat-free mass	1.7	9.7	19.4	-0.0	4.4
Tense / ‘highly strung’	1.7	2.8	4.1	-2.0	1.2
Whole body fat-free mass	1.7	9.8	19.5	0.2	4.4
Whole body water mass	1.7	9.8	19.5	0.1	4.4
Basal metabolic rate	1.7	9.5	18.9	0.2	4.3
Ovarian Cancer	1.6	2.1	4.2	2.1	-0.0
Vitamin and mineral supplements	1.6	2.2	3.8	0.8	-2.0
Medication: Metformin	1.6	2.3	3.4	1.0	1.9
Diabetes (mother)	1.6	2.0	3.8	-0.5	1.9
Leg fat-free mass (left)	1.6	8.7	17.1	0.6	4.1
Average weekly fortified wine intake	1.6	1.8	2.1	-1.2	-1.5
Leg predicted mass (left)	1.6	8.6	16.8	0.7	4.1
Weight	1.6	8.0	15.8	0.5	4.0
Trunk predicted mass	1.6	9.2	18.5	-0.0	4.3
Blood clot in the leg (DVT)	1.6	2.1	4.1	0.0	2.0
Age at last live birth	1.6	2.3	4.6	-0.0	-2.1
Leg fat-free mass (right)	1.6	8.4	16.4	0.6	4.0
Long-standing illness, disability or infirmity	1.6	2.4	4.1	0.8	2.0
Hip circumference	1.5	6.5	12.3	-0.9	3.5
Birth weight	1.5	3.2	5.3	1.1	-2.3
Arm fat-free mass (right)	1.5	7.7	15.4	-0.2	3.9
Leg predicted mass (right)	1.5	8.2	16.1	0.5	4.0
Mean Putamen Volume	1.4	1.6	2.8	0.6	1.7
Triglycerides	1.4	2.3	2.3	1.5	1.5
Chronic bronchitis/emphysema (father)	1.4	1.6	2.9	-0.6	-1.7
Hearing difficulty/problems with background noise	1.4	2.3	4.5	-0.0	2.1
Pulse wave reflection index	1.4	1.8	3.5	1.9	-0.0
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	3.5	-0.2	1.9
Medication: Omeprazole (e.g. Zanprol)	1.4	1.8	3.4	1.8	-0.3
Hearing difficulty/problems: Yes	1.3	2.0	3.9	-0.2	2.0
Hand grip strength (right)	1.3	3.5	4.8	1.5	-2.2
Body mass index (BMI)	1.3	5.4	10.8	-0.1	3.3
Diabetes (self-reported)	1.3	2.0	2.8	1.1	1.7
Birth weight of first child	1.3	2.3	4.4	-2.1	-0.5
Glaucoma (self-reported)	1.3	1.5	2.3	-0.9	-1.5
Age at first live birth	1.3	2.4	4.6	-0.5	-2.1
Health satisfaction	1.3	1.6	2.5	-1.6	-0.9
Emphysema/chronic bronchitis	1.3	1.4	2.8	0.0	1.7
Medication: Omeprazole	1.3	1.6	2.2	1.5	-1.0
Number of full sisters	1.3	1.6	2.9	-0.5	1.7
Qualifications: nursing, teaching	1.3	2.0	3.3	1.8	-0.8
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	3.3	0.1	1.8
Impedance of leg (right)	1.2	6.0	11.8	0.4	-3.4
High blood pressure	1.2	3.3	5.3	1.2	2.3
Medication: Atenolol	1.2	1.5	2.1	1.0	1.4
Impedance of leg (left)	1.2	5.7	11.4	0.0	-3.4
Past tobacco smoking	1.2	2.2	4.5	-2.1	0.2
Pain all over the body in last month	1.2	1.2	2.2	-1.5	-0.5
Ever highly irritable/argumentative for 2 days	1.2	1.4	2.9	0.1	1.7
Medication: Blood pressure	1.2	2.1	4.1	2.0	0.2
Hypertension (Self-reported)	1.2	3.3	4.9	1.3	2.2
Medication: Aspirin	1.2	1.6	2.6	0.8	1.6
Myopia	1.2	1.8	2.0	-1.3	-1.4
Blood Platelet Count	1.1	12.5	24.8	0.3	-5.0
BMI	1.1	6.4	12.8	-0.2	3.6
Allergy or Eczema	1.1	2.8	3.7	1.4	-1.9
Type 2 Diabetes (T2D) (2018)	1.1	2.0	3.0	1.0	1.7
Taking other prescription medications	1.1	1.7	2.5	-0.9	1.6
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	2.0	-1.4	-0.8
Arm fat mass (right)	1.1	4.7	9.1	0.6	3.0
Exposure to tobacco smoke at home	1.1	1.2	2.1	0.6	-1.4
Supplements: Vitamin C	1.1	1.3	2.5	-0.1	1.6
Diabetes diagnosed by doctor	1.1	1.8	1.9	1.4	1.3
Arm fat mass (left)	1.1	4.4	8.5	0.5	2.9
Ever taken oral contraceptive pill	1.1	1.3	2.4	-1.6	0.3
Ever smoked	1.1	2.0	2.7	1.1	-1.6
Number of operations (self-reported)	1.1	1.6	2.4	-0.8	1.6
Irritability	1.1	1.8	3.5	1.9	-0.4
Vascular/heart problems diagnosed by doctor	1.1	2.9	5.6	-0.4	-2.4
Alzheimer’s Disease (in father)	1.0	1.1	1.1	-1.1	-1.0
Bipolar Disorder (2011)	1.0	1.0	1.9	-0.3	-1.4
LDL Cholesterol	1.0	1.5	3.0	1.7	0.2
Type 2 Diabetes (T2D) (2012)	1.0	1.1	2.0	0.5	1.4
Blood Eosinophil Count	1.0	7.3	13.9	0.9	-3.7
Age when periods started (menarche)	1.0	2.3	2.6	1.5	-1.6
Hayfever, allergic rhinitis or eczema	1.0	2.1	2.7	1.2	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.2	4.2	-0.4	-2.0
Medication: Cholesterol lowering	1.0	1.5	2.9	1.7	0.2
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	3.1	-1.8	-0.3
Mouth/teeth dental problems: Loose teeth	1.0	1.2	1.3	-1.1	1.1
Neck or shoulder pain in last month	1.0	1.4	2.7	-1.6	-0.1
Whole body fat mass	1.0	4.4	8.3	0.7	2.9
Medication: Blood pressure	1.0	2.0	3.3	0.8	1.8
Diabetes (father)	0.9	1.1	1.6	0.8	1.3
Allergy	0.9	2.1	3.4	-1.8	0.8
Leg fat percentage (right)	0.9	3.1	6.2	-0.1	2.5
Ever had bowel cancer screening	0.9	1.0	1.9	-1.4	-0.4
Commuting to job workplace: Walk	0.9	0.9	1.7	1.3	0.5
Average weekly champagne plus white wine intake	0.9	1.2	2.3	0.3	-1.5
Commuting to job workplace: Cycle	0.9	1.1	1.3	1.1	1.0
Coronary Artery Disease (CAD)	0.8	0.9	1.4	-0.6	1.2
Cardiovascular Disease	0.8	2.5	4.3	0.8	2.1
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	1.8	0.1	1.3
Multivitamins +/- minerals	0.8	1.0	1.2	-1.1	0.9
Stomach or abdominal pain in last month	0.8	1.0	1.8	1.3	-0.5
Trunk fat mass	0.8	3.2	5.6	0.9	2.4
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	1.8	0.8	1.3
Medication: Simvastatin	0.8	1.1	1.9	0.6	1.4
Illnesses of siblings	0.8	1.1	1.9	-0.5	-1.4
Exposure to tobacco smoke outside home	0.8	1.1	1.9	-0.6	1.4
Mineral and other dietary supplements	0.8	1.0	1.8	0.5	-1.4
Supplements: Fish oil (including cod liver oil)	0.8	1.1	1.5	-0.8	1.2
Leg fat percentage (left)	0.8	3.0	5.9	-0.3	2.4
Unable to work because of sickness or disability	0.8	1.1	2.1	-1.4	0.2
Schizophrenia vs Biploar Disorder	0.7	1.0	1.3	-1.1	0.8
Fasting Glucose	0.7	0.8	1.0	0.8	1.0
Average weekly spirits intake	0.7	0.9	1.6	-0.4	1.3
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.6	-1.3	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	2.9	-0.3	-1.7
Nervous feelings	0.7	1.4	2.4	-0.6	-1.5
Fluid intelligence score	0.7	1.5	2.9	0.3	-1.7
Father’s age at death	0.7	0.9	1.8	1.3	-0.2
Loud music exposure frequency	0.7	0.8	1.2	-0.6	-1.1
Headache pain in last month	0.7	1.2	2.2	-1.5	0.5
Medication: Amlodipine	0.7	1.0	1.7	1.3	0.5
Pulse rate, automated reading	0.7	2.1	4.2	-2.1	0.2
Overall health rating	0.7	1.5	1.7	-1.3	1.2
Knee pain experienced in last month	0.7	1.0	2.0	-0.2	1.4
Illnesses of father: Heart disease	0.7	1.0	2.0	-0.0	1.4
Osteoarthritis (self-reported)	0.7	0.9	1.9	-0.1	1.4
Mother’s age at death	0.7	0.9	1.8	1.3	-0.1
Medication: Lisinopril	0.7	1.0	1.3	1.1	0.8
Blood Red Count	0.6	6.2	11.0	-1.2	-3.3
Height	0.6	11.2	13.3	3.0	3.6
Asthma	0.6	1.2	1.3	1.1	-1.2
Medication: Seretide 50 evohaler	0.6	0.7	0.7	0.9	0.8
Alcohol intake frequency.	0.6	1.4	2.6	0.3	1.6
Handedness (chirality/laterality): Left-handed	0.6	0.8	1.3	1.2	-0.5
Back pain experienced in last month	0.6	0.8	1.0	1.0	-0.8
Asthma (self-reported)	0.6	1.3	1.4	1.1	-1.2
Osteoporosis (self-reported)	0.6	0.8	0.9	0.8	1.0
Guilty feelings	0.6	1.0	1.0	1.0	1.0
Wears glasses or contact lenses	0.6	0.7	1.4	0.4	-1.2
Hearing aid user	0.6	0.6	1.2	0.1	1.1
Alcohol drinker status: Never	0.6	0.7	1.1	1.1	0.6
Ever depressed for a whole week	0.6	0.8	1.5	-0.3	1.2
Pain experienced in last month	0.6	1.0	1.9	1.4	-0.4
Depression (Nagel 2018)	0.5	0.8	0.8	-0.9	0.9
Breast Cancer	0.5	1.2	1.3	-1.0	1.1
HDL Cholesterol	0.5	0.8	1.3	-0.6	-1.2
Lupus	0.5	0.8	1.6	-1.3	0.1
Relative age of first facial hair	0.5	1.0	1.6	-1.2	-0.7
Qualifications: CSEs or equivalent	0.5	0.6	0.8	0.7	0.9
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.4	1.2	-0.2
Arm fat percentage (right)	0.5	2.1	3.6	0.8	1.9
Alcohol intake versus 10 years previously	0.5	0.7	1.1	-0.6	-1.0
Number of live births	0.5	0.7	0.9	1.0	-0.7
Happiness	0.5	0.7	1.0	-1.0	-0.6
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.1	-0.6	1.1
Comparative body size at age 10	0.5	1.4	2.0	-0.9	-1.4
Comparative height size at age 10	0.5	2.7	4.8	0.8	2.2
Leg pain on walking	0.5	0.6	0.8	-0.9	-0.6
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	0.8	-0.6	-0.9
Smoking status: Previous	0.5	0.8	1.5	1.2	-0.2
Arm fat percentage (left)	0.5	1.9	3.3	0.7	1.8
Financial situation satisfaction	0.5	0.6	1.0	1.0	-0.3
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.1	-1.0	-0.1
Worry (Nagel 2018)	0.4	0.8	1.4	-1.2	0.5
Verbal and Numeric Reasoning (VNR)	0.4	1.1	2.1	0.3	-1.4
HbA1C	0.4	0.4	0.8	0.9	-0.0
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	0.5	0.7	-0.7
Hair/balding pattern: Pattern 2	0.4	0.5	0.8	-0.5	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.4	0.8	0.2	-0.9
Pulse wave Arterial Stiffness index	0.4	0.4	0.7	-0.3	0.9
Worry too long after embarrassment	0.4	0.7	1.1	1.0	0.5
Pulse wave peak to peak time	0.4	0.5	0.6	0.6	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	0.6	0.8	-0.6
Breast cancer (self-reported)	0.4	0.5	1.1	0.1	1.0
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.5	0.6	-1.2
Schizophrenia (2018)	0.3	0.7	1.4	0.2	1.2
Alzheimer’s Disease (including proxy)	0.3	0.4	0.8	-0.9	0.2
Blood White Count	0.3	2.1	3.1	-1.0	-1.8
Smoking Status	0.3	0.7	1.1	1.0	0.7
Respiratory disease	0.3	0.7	1.5	1.2	0.1
Hand grip strength (left)	0.3	0.7	1.3	-0.3	-1.1
Medication for hormone replacement therapy	0.3	0.4	0.7	0.2	0.8
Severe depression (siblings)	0.3	0.4	0.6	0.4	0.8
Trunk fat percentage	0.3	1.1	1.3	0.9	1.1
Townsend deprivation index at recruitment	0.3	0.4	0.7	-0.3	-0.8
Sitting height	0.3	2.0	3.8	-0.4	2.0
Financial difficulties in last 2 years	0.3	0.4	0.4	-0.7	0.6
Time employed in main current job	0.3	0.4	0.4	0.6	-0.6
Noisy workplace	0.3	0.4	0.4	-0.6	0.7
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.1	-0.2	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.5	0.5	-0.7
Mouth/teeth dental problems: Dentures	0.3	0.4	0.5	0.6	0.7
Hair/balding pattern: Pattern 4	0.3	0.8	1.0	-1.0	0.8
Forced vital capacity (FVC), Best measure	0.3	1.2	1.6	-1.3	-0.9
Body fat percentage	0.3	1.3	2.3	0.5	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.5	-0.7	0.5
Suffer from ‘nerves’	0.3	0.4	0.8	0.9	-0.1
Chest pain or discomfort	0.3	0.4	0.8	0.9	0.1
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.5	-0.7	-0.5
Friendships satisfaction	0.3	0.3	0.4	-0.6	-0.6
Miserableness	0.3	0.5	1.0	-0.1	-1.0
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.5	0.7	-0.5
Eye problems/disorders: Glaucoma	0.3	0.3	0.6	-0.8	0.2
Alcohol drinker status: Previous	0.3	0.3	0.6	-0.8	-0.2
Neuroticism (Nagel 2018)	0.2	0.4	0.8	-0.0	0.9
Prostate Cancer	0.2	0.3	0.5	-0.3	-0.7
Neuroticism (2016)	0.2	0.2	0.4	-0.7	-0.2
Heel T-Score	0.2	1.7	1.7	-1.3	-1.3
Systolic Blood Pressure	0.2	0.9	1.6	1.3	0.5
Chronotype (morning person)	0.2	0.4	0.8	0.2	0.9
Systolic blood pressure, automated reading	0.2	0.5	1.0	0.2	1.0
Supplements: Zinc	0.2	0.2	0.3	-0.6	0.1
Medication: Co-codamol	0.2	0.3	0.4	-0.6	0.4
Fed-up feelings	0.2	0.3	0.7	0.2	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.4	-0.5	0.6
High blood pressure (mother)	0.2	0.3	0.5	0.7	-0.1
Number of incorrect matches in round	0.2	0.3	0.6	0.1	0.8
Forced vital capacity (FVC)	0.2	0.9	1.0	-1.0	-1.0
Mouth/teeth dental problems	0.2	0.3	0.5	0.2	-0.7
Worrier / anxious feelings	0.2	0.3	0.5	-0.7	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.3	0.4	0.6
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	0.8	0.3
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	0.7	-0.7	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	0.7	-0.9	-0.5
Standing height	0.2	2.2	2.4	1.4	1.6
Breastfed as a baby	0.2	0.2	0.4	0.6	0.3
Gout (self-reported)	0.2	0.2	0.3	-0.5	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.4	-0.2	0.6
Qualifications: College or University degree	0.2	0.6	1.2	0.2	-1.1
Migraine (self-reported)	0.2	0.2	0.3	0.5	0.4
Medication: Ibuprofen	0.2	0.2	0.2	-0.5	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.8	-0.9	0.1
Average weekly red wine intake	0.2	0.3	0.6	0.3	-0.8
Mood swings	0.2	0.3	0.7	-0.8	0.1
Medication: Gliclazide	0.2	0.3	0.3	0.6	0.4
Risk taking	0.2	0.3	0.3	0.6	0.5
Diastolic blood pressure, automated reading	0.2	0.7	1.1	-0.5	1.1
Bipolar Disorder (2018)	0.1	0.2	0.3	0.6	-0.4
Bipolar Disorder or Schizophrenia	0.1	0.4	0.5	0.5	0.7
Alzheimer’s Disease (in mother)	0.1	0.1	0.1	-0.2	0.3
Reaction Time	0.1	0.1	0.2	0.5	0.2
Schizophrenia (2014)	0.1	0.3	0.4	-0.4	0.6
Lung FEV1/FVC ratio	0.1	0.7	1.1	1.0	0.6
Hair Pigment	0.1	1.6	3.0	-0.5	1.7
Tanning	0.1	0.6	1.3	0.0	-1.1
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.3	0.4
Supplements: Glucosamine	0.1	0.1	0.2	0.0	-0.4
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	0.5	0.2
Qualifications: None of the above	0.1	0.2	0.3	0.4	-0.5
Heart attack	0.1	0.2	0.2	-0.3	0.5
Prospective memory result	0.1	0.1	0.2	-0.5	-0.0
Lung cancer (father)	0.1	0.1	0.2	0.2	0.4
Length of working week for main job	0.1	0.1	0.2	-0.2	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.1	-0.4	-0.2
Peak expiratory flow (PEF)	0.1	0.2	0.4	-0.6	-0.3
Medication: Paracetamol	0.1	0.2	0.3	-0.3	-0.6
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.2	-0.4	-0.4
High blood pressure (siblings)	0.1	0.1	0.2	0.1	0.4
Number of children fathered	0.1	0.1	0.2	0.2	-0.5
Medication for pain relief, constipation, heartburn	0.1	0.1	0.2	-0.4	-0.3
Mean time to correctly identify matches	0.1	0.2	0.3	0.0	0.6
Family relationship satisfaction	0.1	0.2	0.2	-0.5	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	-0.3	0.4
Smoking status: Current	0.1	0.2	0.4	0.6	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.2	-0.5	-0.3
Commuting to job workplace: Public transport	0.1	0.2	0.2	-0.3	0.5
High cholesterol (Self-reported)	0.1	0.2	0.4	0.6	0.3
Medication: Bendroflumethiazide	0.1	0.1	0.3	0.5	0.2
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.3	-0.0	0.5
Depressed Affect (Nagel 2018)	0.0	0.0	0.1	-0.3	0.1
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0
Neuroticism	0.0	0.1	0.1	0.1	0.4
Angina	0.0	0.1	0.1	-0.2	0.3
Current tobacco smoking	0.0	0.0	0.1	-0.2	0.2
Maternal smoking around birth	0.0	0.0	0.1	-0.3	0.0
Had menopause	0.0	0.1	0.1	0.3	0.1
Neuroticism score	0.0	0.0	0.1	-0.3	0.0
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.0	0.2	-0.1
Angina (self-reported)	0.0	0.0	0.1	-0.3	0.1
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.1	0.3	0.0
Medication: Paracetamol	0.0	0.0	0.0	0.0	-0.0
Age started oral contraceptive pill	0.0	0.0	0.1	0.3	-0.0

Hub : Genes

ZMIZ1

Models

Trait associations