TWAS
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Traits
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Traits
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Crohns Disease (2017)
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chr21:34,077,531-35,561,665
Best TWAS P=2.42e-07 · Best GWAS P=1.14e-14 conditioned to 0.00179
34M
34.2M
34.4M
34.6M
34.8M
35M
35.2M
35.4M
35.6M
0
5
10
15
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
CommonMind
Brain Pre-frontal Cortex
DNAJC28
0.12
0.15
lasso
3
0.15
7.8e-18
5.2
5.2
2.4e-07
-0.48
1.00
0.00
TRUE
2
GTEx
Muscle Skeletal
IFNGR2
0.08
0.03
enet
15
0.06
2.5e-06
3.5
5.1
2.7e-07
-0.68
0.01
0.99
TRUE