Hub : Genes

IFNGR2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.0840	0.030	7.2e-04	0.026	NA	0.057	NA	0.050	1.3e-03	NA	2.5e-06	NA	1.0e-05
2	YFS	Blood	0.1381	0.022	0.0e+00	0.149	0.182	0.204	0.205	0.205	1.9e-46	2.9e-57	7.2e-65	4.8e-65	5.9e-65
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0402	0.023	7.4e-03	0.001	0.010	0.009	NA	0.002	2.4e-01	2.3e-02	2.7e-02	NA	1.9e-01
4	TCGA	Pheochromocytoma and Paraganglioma	0.1630	0.065	4.8e-05	0.067	0.104	0.112	NA	0.122	1.3e-03	6.3e-05	3.5e-05	NA	1.5e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.1	0.2	0.5	0.5	0.0	-0.7	0.1
Bipolar Disorder or Schizophrenia	1.0	2.3	4.9	0.2	2.0	-0.7	2.2
Depressed Affect (Nagel 2018)	0.2	0.4	0.9	-0.1	-0.8	0.9	-0.1
Depression (Nagel 2018)	0.1	0.2	0.3	-0.2	0.6	-0.1	-0.6
Intelligence (Savage-Jansen 2018)	0.4	1.1	3.9	-0.5	-0.5	0.1	-2.0
Neuroticism (Nagel 2018)	0.1	0.3	1.1	1.1	-0.1	-0.1	0.5
Schizophrenia (2018)	1.7	3.5	7.5	-0.2	2.5	-0.3	2.7
Schizophrenia vs Biploar Disorder	1.9	2.5	7.5	-1.4	2.7	-0.4	0.7
Worry (Nagel 2018)	0.3	0.7	1.4	0.5	0.9	-1.2	0.4
Alzheimer’s Disease (in mother)	0.4	0.5	1.1	0.2	0.8	-0.2	-1.1
Alzheimer’s Disease (in father)	0.3	0.3	1.2	1.1	0.2	-0.2	0.1
Alzheimer’s Disease (including proxy)	0.6	0.9	1.1	0.9	1.1	-0.9	-0.8
Crohns Disease (2017)	4.6	10.1	26.5	5.1	-2.4	-2.7	0.7
Irritable Bowel Disease (IBD)	1.7	4.0	9.7	3.1	-1.3	-1.7	1.3
Ulcerative Colitis (UC)	0.2	0.3	0.9	0.4	-0.2	-0.2	1.0
Major Depression (MDD)	1.1	1.3	3.5	-1.3	1.9	-0.2	0.1
Reaction Time	1.1	2.1	4.5	1.8	0.7	-2.1	-0.3
Verbal and Numeric Reasoning (VNR)	0.8	2.0	7.0	-0.8	-0.1	-0.4	-2.6
Breast Cancer	0.2	0.6	1.6	0.8	-0.3	-0.1	-1.3
Ovarian Cancer	0.3	0.4	0.8	-0.3	0.5	0.6	0.9
Prostate Cancer	0.6	0.8	1.1	0.9	0.7	-1.0	-0.9
Age at First Birth	0.8	1.2	4.5	0.0	0.0	0.3	2.1
Bipolar Disorder (2011)	0.3	0.3	0.9	0.3	-0.4	1.0	0.3
Body Mass Index (BMI) (2010)	1.3	1.8	3.1	1.6	-1.8	0.2	1.3
Coronary Artery Disease (CAD)	1.5	1.7	5.3	2.3	0.3	0.3	1.2
Crohns Disease (2012)	2.4	3.9	8.4	2.9	-0.7	-2.6	0.1
Mean Putamen Volume	0.3	0.3	0.9	-0.9	0.1	0.3	-0.4
Fasting Glucose	0.1	0.2	0.4	-0.1	0.5	0.2	0.7
HbA1C	0.3	0.3	0.7	0.8	-0.1	-0.1	-0.7
HDL Cholesterol	0.2	0.3	0.8	-0.1	0.9	-0.5	0.3
LDL Cholesterol	0.4	0.7	2.0	0.7	-0.2	0.5	1.4
Lupus	1.5	2.3	7.3	0.2	2.7	-1.0	-0.9
Neuroticism (2016)	0.6	0.8	1.7	-1.3	1.2	0.4	-0.1
Primary Biliary Cirrhosis	2.2	3.2	9.6	-1.7	3.1	-0.4	0.1
Rheumatoid Arthritis	5.3	7.3	18.7	0.2	-4.3	3.0	-1.4
Schizophrenia (2014)	1.5	3.4	6.5	-0.4	2.5	-0.6	2.5
Triglycerides	0.4	0.7	1.9	-1.0	-0.2	0.2	-1.4
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.7	0.6	0.4	-0.9	-0.5
Ulcerative Colitis	0.2	0.3	0.6	-0.5	0.8	-0.6	0.4
Blood Eosinophil Count	1.1	8.7	20.0	1.8	-4.5	2.9	1.8
Blood Platelet Count	0.5	5.5	14.0	-3.7	0.7	1.8	-2.1
Blood Red Count	0.6	6.1	19.4	-0.2	4.4	-2.2	-0.1
Blood White Count	0.1	0.6	1.3	1.1	-0.2	-0.6	0.8
Heel T-Score	0.6	5.0	10.7	-2.2	0.8	-1.9	-3.3
BMI	0.2	1.0	1.5	0.3	-1.0	1.2	1.1
Height	0.1	2.4	7.2	-0.3	2.7	-0.1	1.6
Waist Hip Ratio (WHR)	0.2	1.1	3.0	0.4	-0.2	1.1	1.7
Systolic Blood Pressure	0.7	3.6	5.9	1.6	2.4	-2.0	1.4
Smoking Status	0.6	1.4	2.2	1.5	-1.2	-0.8	-1.1
Allergy or Eczema	0.4	1.1	2.3	-0.6	-0.1	1.5	1.3
Cardiovascular Disease	0.6	2.0	3.7	1.9	1.4	-1.0	1.2
Hypothyroidism (self reported)	0.3	0.6	1.0	1.0	-0.7	0.9	-0.5
Respiratory disease	0.6	1.3	4.3	0.1	-0.1	-0.9	-2.1
Type 2 Diabetes (T2D) (2018)	0.1	0.3	0.8	-0.0	-0.2	0.9	0.5
Lung FEV1/FVC ratio	0.4	1.8	3.5	1.7	-1.9	0.1	-0.9
Lung FVC	0.1	0.7	1.7	1.0	-1.3	0.4	-0.2
Neuroticism	0.0	0.1	0.2	0.0	0.1	-0.3	-0.4
Chronotype (morning person)	0.1	0.3	0.6	0.6	-0.7	0.1	0.5
Hair Pigment	0.0	0.9	2.5	0.2	0.3	-1.6	-1.0
Tanning	0.2	2.4	4.9	1.3	-1.0	2.2	1.4
Hand grip strength (left)	2.0	5.3	12.7	-2.7	3.6	-1.0	0.6
Number of treatments/medications taken	1.7	3.0	4.8	1.5	-2.2	0.7	2.1
Average weekly spirits intake	0.3	0.4	0.8	-0.9	0.8	-0.2	-0.0
Sensitivity / hurt feelings	0.2	0.4	1.2	-0.4	0.5	0.4	1.1
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.6	-1.2	0.2	1.3	0.4
Hearing difficulty/problems: Yes	1.0	1.6	3.4	-1.8	1.6	-0.5	0.1
Relative age of first facial hair	0.6	1.1	3.0	-0.6	1.7	-1.1	-0.1
Other serious medical condition/disability diagnosed by doctor	2.0	2.7	6.4	2.5	-1.4	0.4	1.5
Ever used hormone-replacement therapy (HRT)	1.0	1.3	2.9	1.7	-0.6	-0.2	1.3
Ever had hysterectomy (womb removed)	0.8	0.9	1.8	1.1	-0.0	-1.3	-0.7
Systolic blood pressure, automated reading	1.2	3.5	6.2	1.7	2.1	-2.5	0.9
Eye problems/disorders: Diabetes related eye disease	1.6	1.8	5.5	2.3	-0.9	-0.6	0.8
Angina	0.2	0.2	0.4	0.6	0.6	-0.3	-0.1
Medication for hormone replacement therapy	1.3	1.5	3.2	1.8	-0.2	-0.8	1.4
Vitamin and mineral supplements	0.2	0.2	0.7	-0.3	0.9	0.3	0.0
Supplements: Zinc	0.3	0.3	0.9	-0.6	-0.3	-0.9	-0.1
Medication: Co-codamol	0.5	0.6	1.4	-0.2	-0.3	1.2	0.9
Medication: Metformin	0.2	0.3	0.9	0.9	-0.3	-0.0	-0.4
Diabetes (father)	0.4	0.5	0.9	0.6	0.9	-0.9	0.3
Diabetes (mother)	0.9	1.2	2.5	0.1	-1.0	1.6	1.1
Severe depression (siblings)	0.1	0.1	0.4	-0.1	0.5	-0.6	0.1
Pack years adult smoking proportion	0.3	0.4	1.1	-0.1	0.7	-0.1	1.1
Impedance of leg (right)	0.1	0.7	1.2	1.1	-0.5	0.3	1.1
Leg fat-free mass (left)	0.1	0.7	1.1	-1.0	1.1	0.8	0.5
Trunk fat percentage	0.2	0.7	1.3	-0.5	0.9	1.1	0.8
Hand grip strength (right)	1.5	3.9	7.2	-2.7	2.6	-1.2	-0.6
Townsend deprivation index at recruitment	0.1	0.1	0.3	-0.0	0.6	0.2	-0.5
Current tobacco smoking	0.2	0.4	0.8	-0.2	-0.4	-0.7	-0.9
Average weekly fortified wine intake	1.6	1.9	5.7	0.3	1.3	-2.4	-0.0
Maternal smoking around birth	0.2	0.3	0.8	0.9	-0.1	0.6	0.2
Fed-up feelings	0.1	0.2	0.4	0.0	-0.4	-0.4	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.7	-0.8	0.6	0.5	0.0
Relative age voice broke	1.5	2.3	5.9	0.4	1.6	-2.4	-0.7
Taking other prescription medications	1.3	2.0	4.1	0.9	-1.1	1.4	2.0
Age when periods started (menarche)	0.1	0.2	0.5	0.7	-0.2	-0.0	-0.7
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.8	-0.3	-0.4	-0.6	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	3.0	-1.7	-0.2	-0.7	-1.2
Tinnitus: Yes, but not now, but have in the past	2.4	2.5	7.1	-1.7	2.7	-0.5	-0.1
Qualifications: CSEs or equivalent	0.1	0.1	0.4	0.2	0.1	-0.2	0.6
Serious illness, injury or assault to yourself	0.2	0.2	0.6	-0.6	-0.3	0.8	-0.0
High blood pressure	0.9	2.4	5.0	2.2	1.5	-1.5	0.4
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.6	-1.2	-0.3	1.3	0.3
Multivitamins +/- minerals	0.2	0.3	1.0	0.0	-1.0	0.5	-0.1
Stomach or abdominal pain in last month	0.2	0.2	0.3	-0.6	0.3	0.5	0.5
Supplements: Glucosamine	0.4	0.6	1.2	-1.1	-0.3	0.4	-0.9
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.1	0.5	1.4	-0.5	0.5
Medication: Atenolol	0.8	1.0	2.2	-1.2	0.7	-0.0	-1.5
Medication: Levothyroxine sodium	0.7	1.2	2.1	1.3	-0.7	1.5	0.8
Sitting height	0.1	0.4	0.7	-0.2	0.8	0.9	0.3
Chronic bronchitis/emphysema (father)	0.5	0.6	1.3	0.1	-0.9	1.1	0.5
High blood pressure (mother)	2.2	3.1	7.5	1.2	1.8	-2.7	-0.2
Body mass index (BMI)	0.2	0.9	2.5	-0.5	-0.3	1.6	0.7
Impedance of leg (left)	0.1	0.5	1.2	1.1	0.0	-0.2	0.8
Leg predicted mass (left)	0.2	0.8	1.1	-1.0	1.1	1.0	0.6
Trunk fat mass	0.2	0.9	1.6	-0.5	0.9	1.3	0.9
Waist circumference	0.3	0.9	1.9	-0.2	0.3	1.3	1.4
Number of incorrect matches in round	0.6	0.9	2.0	1.4	-0.4	-0.2	1.2
Past tobacco smoking	1.2	2.3	5.7	-2.4	1.8	0.5	-0.2
Alcohol usually taken with meals	0.2	0.4	1.0	0.3	-0.6	1.0	0.3
Nervous feelings	0.3	0.6	1.4	0.1	0.9	-1.2	-0.0
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.0	-0.1	1.0	-0.8	-0.0
Hearing difficulty/problems with background noise	0.6	1.0	2.3	-1.1	1.5	-0.8	0.0
Hair/balding pattern: Pattern 2	0.6	0.8	2.3	-1.5	-0.2	0.5	0.7
Had menopause	0.7	0.8	1.5	0.8	1.0	-1.2	0.1
Had other major operations	1.6	2.0	3.9	1.5	-0.4	1.2	2.0
Forced vital capacity (FVC)	0.2	0.9	2.5	-0.2	1.1	-0.2	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	1.8	-1.3	-0.1	-1.0	-1.2
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.4	-0.6	0.3	-0.0	0.4
Qualifications: None of the above	0.4	0.8	1.2	1.0	-0.9	-0.1	1.1
Financial difficulties in last 2 years	0.5	0.7	1.3	1.1	-0.8	0.1	-0.8
Mouth/teeth dental problems	2.0	3.1	6.7	-0.3	-2.0	1.2	-2.6
Heart attack	0.2	0.3	0.9	0.1	-0.5	0.4	0.9
Allergy	0.6	1.3	3.8	2.0	0.1	-1.2	0.3
Pain all over the body in last month	1.3	1.4	3.0	1.7	-0.5	-1.4	0.5
Diabetes (self-reported)	0.9	1.4	3.3	0.3	-0.7	1.8	1.4
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	2.6	-1.6	1.3	0.9	0.8
Medication: Ramipril	0.4	0.5	1.0	0.9	-0.0	-1.0	-0.3
Medication: Simvastatin	0.7	1.0	2.8	1.7	-0.3	-0.1	1.0
Fluid intelligence score	0.6	1.3	2.3	-1.0	0.0	-1.4	-1.5
Illnesses of siblings	0.5	0.7	1.3	-0.9	0.2	1.1	-0.8
Neuroticism score	0.1	0.1	0.4	-0.6	0.2	-0.2	-0.0
Weight	0.3	1.3	2.9	-0.7	0.6	1.7	1.1
Impedance of arm (right)	0.4	2.0	5.9	-0.1	2.4	-1.4	0.5
Arm fat percentage (right)	0.2	0.6	0.7	-0.6	0.8	0.9	0.9
Trunk fat-free mass	0.1	0.7	1.4	-0.7	0.1	1.2	0.9
Hip circumference	0.3	1.5	3.6	-1.4	0.5	1.9	0.4
Time employed in main current job	0.8	0.9	2.5	0.3	-1.6	0.9	-0.6
Alcohol intake versus 10 years previously	1.9	2.9	7.1	1.7	-0.6	1.0	2.7
Father’s age at death	0.8	1.0	1.6	-1.1	-1.3	1.1	0.1
Worrier / anxious feelings	0.5	0.9	2.1	-0.4	1.1	-1.4	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	-0.3	0.5	-0.7	0.2
Falls in the last year	1.1	1.5	3.3	0.4	1.8	-0.9	1.3
Hair/balding pattern: Pattern 3	0.9	1.3	2.6	1.3	-1.0	-0.1	-1.6
Number of live births	1.3	1.8	3.7	0.2	1.9	-1.7	-0.6
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	1.5	0.5	0.4	0.2	-1.2
Pulse rate	0.3	0.5	1.7	0.1	1.3	-0.2	-0.6
Happiness	0.1	0.1	0.4	-0.1	0.4	-0.2	0.6
Noisy workplace	0.1	0.1	0.1	-0.1	0.4	0.2	-0.3
Qualifications: A levels/AS levels or equivalent	0.4	0.8	2.5	-0.7	0.4	-1.6	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	2.6	1.6	0.8	-1.0	0.1
Mouth/teeth dental problems: Dentures	0.9	1.6	4.4	1.1	0.8	0.3	2.1
Asthma	0.5	0.9	1.8	-0.8	-1.3	0.7	-0.9
Medication: Ibuprofen (e.g. Nurofen)	2.0	2.5	8.0	0.9	-2.8	1.0	-0.6
Medication: Cholesterol lowering	0.9	1.4	2.5	1.6	-1.6	0.6	0.6
Depression (self-reported)	1.3	1.5	3.4	0.2	-0.8	1.8	1.4
Medication: Lansoprazole	0.7	0.8	1.5	0.7	-1.0	0.3	1.2
Prospective memory result	0.2	0.2	0.4	0.5	-0.6	-0.3	-0.3
Lung cancer (father)	2.2	2.6	4.8	1.8	-2.2	-0.1	1.5
Illnesses of mother	2.3	2.9	7.5	-2.7	0.9	1.3	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.6	0.8	0.4	0.3	-0.4
Pulse wave Arterial Stiffness index	1.1	1.3	4.0	0.3	2.0	-1.1	-0.3
Impedance of arm (left)	0.3	1.3	3.7	0.0	1.9	-1.3	0.1
Arm fat mass (right)	0.3	1.2	1.8	-1.1	0.8	1.4	1.0
Trunk predicted mass	0.1	0.7	1.4	-0.7	0.2	1.2	0.9
Standing height	0.1	1.4	3.8	-0.7	1.9	0.7	0.8
Length of working week for main job	1.4	1.5	3.9	0.9	-2.0	1.1	0.5
Exposure to tobacco smoke at home	0.3	0.3	0.5	-0.6	0.3	-0.7	0.5
Breastfed as a baby	3.2	4.0	9.3	-0.6	2.4	-3.1	-0.9
Tense / ‘highly strung’	0.1	0.1	0.3	-0.5	-0.0	-0.2	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.4	-0.6	-0.3	0.5	0.6
Hair/balding pattern: Pattern 4	0.3	0.6	1.5	0.8	0.1	0.7	1.2
Birth weight of first child	1.4	2.6	6.5	-1.9	-0.1	0.6	-2.6
Peak expiratory flow (PEF)	0.8	1.8	4.4	1.1	-2.1	1.1	-0.7
Pulse wave reflection index	0.2	0.3	0.6	0.4	0.3	-0.8	-0.4
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.1	-1.3	0.4	0.4	-1.5
Loud music exposure frequency	0.4	0.5	1.1	0.5	-1.0	0.0	-0.7
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.4	-0.6	-0.2	0.2	-0.4
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	-0.4	-0.3	-0.3	0.3
Blood clot in the leg (DVT)	0.4	0.5	1.4	-0.4	0.5	0.5	1.2
Medication: Paracetamol	0.5	0.8	2.3	0.5	-0.4	0.8	1.5
Headache pain in last month	0.2	0.3	0.7	-0.3	0.4	0.3	0.8
Medication for cholesterol, blood pressure or diabetes	0.6	1.1	3.1	-1.8	0.6	0.8	-0.4
Glaucoma (self-reported)	0.2	0.2	0.7	-0.2	0.9	0.0	-0.1
Gout (self-reported)	0.5	0.7	1.5	-1.0	0.3	0.1	1.2
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	4.0	0.5	-0.8	2.0	0.3
Medication: Amlodipine	1.2	1.7	5.6	0.4	0.2	-1.0	-2.4
Medication: Ventolin 100micrograms inhaler	1.8	2.3	5.4	-2.3	-0.5	1.1	-1.6
Birth weight	0.8	1.7	5.3	0.5	-1.1	2.3	0.6
Chronic bronchitis/emphysema (mother)	1.4	1.7	4.3	1.2	-0.5	-0.8	2.1
High blood pressure (siblings)	0.3	0.5	1.3	0.3	0.2	-1.1	-0.6
Forced vital capacity (FVC), Best measure	0.1	0.5	1.4	0.6	1.2	-0.2	-0.3
Body fat percentage	0.2	0.6	1.1	-0.2	0.6	1.1	1.0
Leg fat percentage (right)	0.2	0.9	2.1	0.3	-0.2	1.2	1.4
Arm fat-free mass (right)	0.2	0.9	2.4	-0.8	-0.4	1.5	0.5
Exposure to tobacco smoke outside home	1.3	1.7	4.2	1.1	1.1	-0.7	2.0
Comparative body size at age 10	0.3	0.8	2.5	1.6	-0.5	-0.6	-0.0
Number of full brothers	0.3	0.3	0.6	-0.6	0.7	-0.3	0.6
Worry too long after embarrassment	0.2	0.3	0.6	-0.2	-0.7	0.4	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.3	-0.6	-0.1	-0.2	-0.3
Wheeze or whistling in the chest in last year	0.5	0.9	3.2	-1.8	0.7	-0.0	0.2
Number of children fathered	1.7	1.9	5.1	0.3	-2.3	1.4	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	1.2	-1.1	0.4	1.1	1.0
Age at first live birth	0.4	0.7	1.6	-1.3	0.6	0.3	-0.9
Pulse wave peak to peak time	1.0	1.2	2.7	-0.4	-1.6	1.2	0.5
Health satisfaction	1.1	1.4	2.2	1.5	1.4	-0.6	1.1
Shortness of breath walking on level ground	0.3	0.4	0.9	-0.0	0.8	-0.0	-0.9
Qualifications: College or University degree	0.3	0.9	1.6	-1.3	0.6	-0.6	-1.0
Eye problems/disorders: None of the above	1.6	1.9	2.7	-1.6	-0.5	1.4	-1.6
Mouth/teeth dental problems: Loose teeth	3.4	4.0	8.0	2.8	-0.3	-0.6	2.8
Emphysema/chronic bronchitis	1.0	1.1	2.3	0.9	0.9	-1.5	-0.7
Medication for pain relief, constipation, heartburn	2.4	4.1	7.5	-1.3	2.3	-1.4	-2.7
Neck or shoulder pain in last month	0.0	0.1	0.1	0.1	-0.2	0.2	0.4
Medication: Blood pressure	0.2	0.4	0.8	0.8	-0.2	-0.9	-0.1
Angina (self-reported)	0.1	0.2	0.4	0.6	0.5	-0.2	-0.1
Migraine (self-reported)	0.4	0.5	1.3	-0.4	0.6	0.2	1.1
Medication: Ibuprofen	1.5	1.8	5.7	1.0	-2.4	0.4	-0.7
Medication: Allopurinol	0.2	0.3	1.1	-0.3	0.1	-0.3	1.1
Medication: Omeprazole	3.6	4.3	15.4	1.2	0.4	0.6	3.9
Medication: Seretide 50 evohaler	0.2	0.2	0.5	-0.2	0.1	0.4	-0.7
Mean time to correctly identify matches	1.0	1.9	3.8	1.9	0.5	-2.0	-0.3
Heart disease (mother)	2.7	3.2	6.7	0.9	-2.6	2.3	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.5	1.2	-0.8	-0.8	-0.5
Whole body fat mass	0.2	0.8	1.8	-0.5	0.6	1.3	0.9
Leg fat mass (right)	0.2	0.7	1.7	-0.4	0.1	1.3	1.0
Arm predicted mass (right)	0.2	0.8	2.2	-0.6	-0.3	1.5	0.6
Pulse rate, automated reading	0.3	0.8	2.2	1.5	0.5	-0.0	0.9
Alcohol intake frequency.	0.8	1.8	3.6	1.7	0.5	-0.5	1.9
Comparative height size at age 10	0.1	0.4	0.8	-0.6	0.7	0.9	0.4
Number of full sisters	0.8	0.9	2.5	-0.1	0.9	-1.6	0.6
Suffer from ‘nerves’	0.2	0.3	0.6	-0.2	0.6	-0.8	-0.2
Overall health rating	0.4	0.8	2.0	0.7	-0.2	-0.7	1.4
Chest pain or discomfort	0.2	0.3	0.7	-0.8	0.7	0.3	-0.1
Had major operations	1.6	1.8	3.5	1.9	-1.3	0.2	1.5
Age at last live birth	0.8	1.2	2.5	-0.5	1.6	-1.3	-0.6
Family relationship satisfaction	0.7	0.8	2.1	1.4	-0.2	-1.1	-0.0
Leg pain on walking	0.3	0.4	0.8	-0.9	0.5	0.6	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	1.0	-1.0	0.3	-0.2	0.0
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.1	-0.6	1.1	0.1	-0.2
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	2.9	0.7	-0.3	-0.4	1.7
Medication: Aspirin	3.1	4.1	6.3	1.7	-2.5	1.3	2.3
Supplements: Vitamin C	0.7	0.9	3.0	0.2	-0.0	-1.7	0.7
Knee pain experienced in last month	0.5	0.7	2.6	0.1	-0.4	1.6	0.3
Hypertension (Self-reported)	0.7	2.0	3.6	1.9	1.4	-1.5	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	3.1	0.6	0.0	-1.1	1.8
Illnesses of father: Heart disease	1.4	1.9	4.7	-2.2	0.6	1.6	0.1
Illnesses of siblings: Diabetes	1.0	1.2	3.2	1.1	-0.5	0.4	1.8
Smoking status: Previous	1.4	2.1	5.3	2.3	-1.6	-0.3	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	0.9	0.9	0.1	0.6	0.2
Whole body fat-free mass	0.1	0.7	1.3	-0.7	0.5	1.2	0.8
Leg fat-free mass (right)	0.2	0.8	1.9	-0.9	1.4	0.7	0.5
Arm fat percentage (left)	0.1	0.5	0.7	-0.6	0.6	0.8	0.7
Average weekly red wine intake	0.8	1.2	3.9	-0.3	0.7	-0.5	-2.0
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.5	-0.1	0.4	-0.4	-0.7
Mood swings	0.1	0.2	0.5	-0.7	-0.0	0.1	-0.4
Loneliness, isolation	0.4	0.6	1.8	-1.3	0.6	0.2	-0.5
Long-standing illness, disability or infirmity	0.6	1.0	1.7	1.1	-0.5	0.9	1.3
Ever had bowel cancer screening	0.1	0.2	0.3	-0.5	0.3	-0.2	-0.5
Diabetes diagnosed by doctor	0.8	1.3	2.8	0.4	-0.6	1.4	1.7
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.3	0.8	-1.1	0.4	0.0
Friendships satisfaction	0.1	0.1	0.3	0.4	-0.2	-0.6	0.1
Qualifications: nursing, teaching	0.5	0.8	1.2	-1.0	0.5	-1.1	-0.8
Commuting to job workplace: Walk	0.6	0.7	1.6	-0.6	-0.2	-1.3	-0.8
Eye problems/disorders: Cataract	1.7	1.9	3.4	1.8	-1.5	-1.0	1.1
Mouth/teeth dental problems: Mouth ulcers	2.2	3.6	8.8	-0.5	3.0	-1.6	1.6
Medication for cholesterol	1.2	1.8	3.0	-1.7	-1.3	0.5	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.5	-0.3	0.4	-0.5	-0.7
Back pain experienced in last month	3.0	4.4	13.5	0.9	-3.7	1.6	-0.9
Mineral and other dietary supplements	1.1	1.5	4.0	0.8	1.2	-2.0	-0.4
Breast cancer (self-reported)	1.2	1.4	1.9	-1.2	1.4	-1.0	-1.2
Asthma (self-reported)	0.4	0.8	1.3	-0.7	-1.2	0.9	-0.7
Osteoporosis (self-reported)	1.4	1.8	4.9	2.2	0.0	-1.4	0.4
Osteoarthritis (self-reported)	1.6	2.0	5.7	2.4	-1.5	-0.3	-0.2
Medication: Aspirin	3.6	4.7	6.9	2.2	-2.3	1.3	2.6
Medication: Gliclazide	0.6	0.7	2.5	-0.1	0.2	-0.6	-1.6
Illnesses of father: None of the above (group 1)	0.2	0.3	0.3	0.5	-0.5	-0.6	-0.5
Smoking status: Current	0.3	0.5	1.4	-0.3	-0.7	-0.2	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.9	1.0	-0.5	0.0	-0.1
Whole body water mass	0.1	0.7	1.4	-0.9	0.5	1.2	0.7
Leg predicted mass (right)	0.1	0.8	1.9	-0.9	1.4	0.6	0.4
Arm fat mass (left)	0.2	0.8	1.6	-0.9	0.6	1.3	0.7
Number of self-reported non-cancer illnesses	1.1	1.9	5.5	2.4	-0.8	0.4	1.1
Average weekly champagne plus white wine intake	0.6	0.8	1.4	-1.1	-0.4	-0.7	-1.2
Miserableness	0.3	0.6	1.2	-1.1	-0.3	0.9	-0.3
Guilty feelings	0.1	0.2	0.3	-0.6	0.2	0.5	0.2
Wears glasses or contact lenses	0.9	1.1	3.2	1.8	-0.9	-0.0	0.5
Ever taken oral contraceptive pill	0.9	1.0	2.5	-0.1	-0.2	1.2	1.6
Hearing aid user	0.7	0.8	2.2	-0.0	1.0	-1.5	-0.3
Mother’s age at death	0.5	0.6	2.0	0.5	-1.4	0.2	0.5
Financial situation satisfaction	0.5	0.6	1.4	-0.6	1.2	-0.2	-0.8
Tinnitus: Yes, now most or all of the time	0.4	0.4	0.8	-0.1	-0.6	0.9	0.7
Commuting to job workplace: Public transport	0.3	0.3	1.1	0.4	-1.0	0.4	0.2
Eye problems/disorders: Glaucoma	0.3	0.4	1.2	0.2	1.1	-0.4	0.1
Medication: Blood pressure	0.3	0.7	1.4	0.9	1.2	-0.5	0.5
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.5	-0.7	-0.9	1.2	-0.3
Supplements: Fish oil (including cod liver oil)	0.8	1.0	2.0	-0.7	-0.6	1.4	1.1
High cholesterol (Self-reported)	0.8	1.5	3.0	1.7	-0.3	-0.1	1.7
Medication: Bendroflumethiazide	0.3	0.4	1.5	0.4	0.1	0.2	-1.2
Medication: Paracetamol	0.8	1.2	2.3	1.2	-0.9	0.7	1.5
Medication: Lisinopril	0.2	0.3	0.4	0.6	0.6	-0.5	0.5
Medication: Atorvastatin	0.8	1.0	2.4	-0.8	1.5	0.1	1.0
Illnesses of father: High blood pressure	0.4	0.5	2.0	0.3	-0.2	0.0	1.4
Alcohol drinker status: Never	1.5	1.9	3.6	0.2	-1.6	1.9	1.1
Ever smoked	0.2	0.4	0.7	0.8	-0.7	-0.5	-0.3
Basal metabolic rate	0.2	0.9	1.7	-0.7	0.6	1.3	0.9
Leg fat percentage (left)	0.2	0.7	1.8	0.3	0.2	0.9	1.3
Arm fat-free mass (left)	0.2	1.2	3.7	-0.5	-0.4	1.9	0.9
Number of operations (self-reported)	0.3	0.4	0.8	0.4	-0.2	0.9	0.8
Average weekly beer plus cider intake	3.6	5.1	13.3	-2.5	3.6	-0.4	1.0
Irritability	0.2	0.4	0.6	0.7	-0.8	0.5	0.4
Risk taking	1.2	1.7	3.3	0.0	1.8	-1.8	0.6
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.0	1.4	-0.7	-0.7	0.3
Fractured/broken bones in last 5 years	0.6	0.8	2.4	0.6	-0.2	-1.6	-0.5
Age started oral contraceptive pill	0.8	1.0	1.8	-1.2	1.3	-0.8	0.3
Diastolic blood pressure, automated reading	2.5	7.7	11.5	2.5	3.4	-3.2	1.7
Ever depressed for a whole week	1.7	2.1	4.0	-2.0	-0.4	1.6	1.3
Unable to work because of sickness or disability	0.3	0.3	1.1	0.0	0.2	-1.1	-0.4
Commuting to job workplace: Cycle	0.1	0.2	0.3	-0.3	0.6	-0.2	0.4
Myopia	1.1	1.6	3.6	-0.4	1.3	-1.9	-1.0
Vascular/heart problems diagnosed by doctor	0.9	2.5	5.9	-2.4	-1.2	1.6	-0.3
Cholesterol lowering medication	2.0	3.0	7.6	0.8	2.0	0.1	2.8
Medication: Omeprazole (e.g. Zanprol)	3.4	4.2	15.1	0.9	0.4	0.8	3.9
Pain experienced in last month	1.0	1.7	3.4	-0.5	1.8	-1.6	-0.7
Supplements: Calcium	0.6	0.7	2.4	0.5	-1.6	0.4	-0.1
Basal cell carcinoma (self-reported)	3.2	3.8	8.0	2.5	-0.0	-1.0	2.8
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.2	0.6	-0.6	0.2	1.1
Deep venous thrombosis (DVT) (self-reported)	0.7	1.0	3.2	0.1	0.3	0.8	1.8
Heart disease (siblings)	1.1	1.3	2.2	1.2	-1.2	-0.5	1.5
Alcohol drinker status: Previous	0.5	0.6	1.7	0.8	0.3	-1.3	0.3
Pack years of smoking	0.2	0.4	0.8	0.3	0.6	-0.4	0.9
Impedance of whole body	0.2	1.0	2.2	0.6	1.5	-1.0	0.6
Leg fat mass (left)	0.1	0.6	1.1	-0.3	0.3	1.1	1.0
Arm predicted mass (left)	0.3	1.3	3.9	-0.6	-0.4	2.0	0.8