Hub : Genes

DNAJC28

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.123 0.027 4.4e-11 0.153 0.092 0.137 0.14 0.150 3.9e-18 2.6e-11 2.6e-16 1.2e-16 7.8e-18
2 GTEx Thyroid 0.092 0.033 1.5e-03 -0.003 NA 0.018 NA 0.003 7.2e-01 NA 1.4e-02 NA 1.8e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.9 1.5 2.8 -0.3 1.7
Bipolar Disorder or Schizophrenia 2.1 5.1 6.4 -2.5 1.9
Depressed Affect (Nagel 2018) 0.9 1.9 2.9 1.7 -0.9
Depression (Nagel 2018) 0.4 0.6 1.1 0.4 -1.0
Intelligence (Savage-Jansen 2018) 0.5 1.6 3.2 -1.8 0.2
Neuroticism (Nagel 2018) 0.4 0.8 1.5 1.2 -0.3
Schizophrenia (2018) 2.5 5.1 8.9 -3.0 1.1
Schizophrenia vs Biploar Disorder 0.4 0.5 1.1 -1.0 -0.1
Worry (Nagel 2018) 0.8 1.7 2.6 0.9 -1.6
Alzheimer’s Disease (in mother) 0.2 0.2 0.3 -0.2 -0.6
Alzheimer’s Disease (in father) 2.2 2.4 3.6 -1.1 1.9
Alzheimer’s Disease (including proxy) 1.3 1.8 2.2 -1.5 1.2
Crohns Disease (2017) 6.5 14.2 26.7 5.2 -1.3
Irritable Bowel Disease (IBD) 4.4 10.5 16.2 4.0 -2.2
Ulcerative Colitis (UC) 1.8 3.4 3.6 1.8 -1.9
Major Depression (MDD) 3.2 3.9 7.3 -2.7 -0.7
Reaction Time 0.0 0.1 0.1 0.1 -0.3
Verbal and Numeric Reasoning (VNR) 0.7 1.7 3.1 0.6 -1.7
Breast Cancer 0.9 2.1 3.3 1.8 -0.9
Ovarian Cancer 1.3 1.8 2.3 -1.5 1.1
Prostate Cancer 1.8 2.5 3.1 -1.4 1.8
Age at First Birth 0.4 0.5 1.0 -0.1 1.0
Bipolar Disorder (2011) 0.5 0.5 0.8 0.9 -0.4
Body Mass Index (BMI) (2010) 0.9 1.3 1.4 -1.1 1.2
Coronary Artery Disease (CAD) 4.5 5.4 10.2 -0.8 3.2
Crohns Disease (2012) 3.7 5.9 10.7 3.3 -1.1
Mean Putamen Volume 0.2 0.3 0.5 -0.7 -0.2
Fasting Glucose 1.5 1.8 2.0 -1.4 1.2
HbA1C 1.2 1.3 1.8 1.3 0.9
HDL Cholesterol 0.4 0.6 1.2 -1.1 0.3
LDL Cholesterol 1.0 1.6 2.4 -0.8 1.6
Lupus 0.6 0.9 1.1 -0.9 1.1
Neuroticism (2016) 1.1 1.6 2.9 -1.7 0.6
Primary Biliary Cirrhosis 0.6 0.9 1.8 -1.3 0.0
Rheumatoid Arthritis 4.4 6.0 11.7 3.4 -0.5
Schizophrenia (2014) 1.3 2.9 3.8 -1.9 1.4
Triglycerides 0.8 1.4 1.7 1.3 -1.0
Type 2 Diabetes (T2D) (2012) 0.8 0.9 1.9 -1.4 0.0
Ulcerative Colitis 1.2 1.7 2.9 0.7 -1.7
Blood Eosinophil Count 0.2 1.6 3.2 1.8 0.1
Blood Platelet Count 0.2 2.6 4.3 -1.0 -2.1
Blood Red Count 1.0 9.3 10.5 -3.2 2.9
Blood White Count 0.8 5.8 6.9 -2.2 2.6
Heel T-Score 1.4 10.8 18.6 1.8 -4.3
BMI 0.3 1.5 2.0 -1.4 1.0
Height 0.6 11.9 19.0 -2.2 4.4
Waist Hip Ratio (WHR) 0.4 1.7 3.4 -0.1 1.8
Systolic Blood Pressure 2.1 10.3 12.2 -2.9 3.5
Smoking Status 0.3 0.6 1.1 1.1 0.2
Allergy or Eczema 1.2 3.1 3.6 1.9 -1.6
Cardiovascular Disease 2.3 7.6 11.5 -1.9 3.4
Hypothyroidism (self reported) 4.1 9.5 17.1 4.1 -1.4
Respiratory disease 0.0 0.1 0.1 -0.0 -0.4
Type 2 Diabetes (T2D) (2018) 0.0 0.1 0.1 -0.3 -0.0
Lung FEV1/FVC ratio 1.0 5.1 9.7 3.1 -0.7
Lung FVC 0.4 2.2 3.4 1.8 -1.0
Neuroticism 0.8 1.8 2.7 1.0 -1.7
Chronotype (morning person) 0.2 0.6 0.8 0.9 0.6
Hair Pigment 0.1 4.1 5.4 2.3 -1.7
Tanning 0.3 3.1 6.0 -0.3 2.5
Hand grip strength (left) 1.1 2.8 5.6 -2.4 0.0
Number of treatments/medications taken 0.7 1.3 2.6 1.6 0.1
Average weekly spirits intake 0.4 0.5 0.7 0.9 -0.6
Sensitivity / hurt feelings 0.8 1.3 2.2 0.7 -1.5
Frequency of depressed mood in last 2 weeks 1.4 2.0 4.0 0.2 -2.0
Hearing difficulty/problems: Yes 1.1 1.8 3.4 -1.8 -0.3
Relative age of first facial hair 0.2 0.5 0.8 0.9 -0.4
Other serious medical condition/disability diagnosed by doctor 2.2 2.9 3.7 1.9 1.4
Ever used hormone-replacement therapy (HRT) 0.6 0.7 0.9 0.9 0.7
Ever had hysterectomy (womb removed) 0.5 0.6 0.7 0.8 -0.7
Systolic blood pressure, automated reading 2.5 7.2 9.7 -2.2 3.1
Eye problems/disorders: Diabetes related eye disease 2.0 2.2 4.3 2.1 -0.2
Angina 0.6 0.8 1.2 -1.1 0.6
Medication for hormone replacement therapy 0.4 0.5 0.9 -0.1 1.0
Vitamin and mineral supplements 0.2 0.3 0.5 -0.2 -0.7
Supplements: Zinc 2.2 2.4 3.6 1.1 -1.9
Medication: Co-codamol 0.1 0.1 0.2 -0.0 0.5
Medication: Metformin 0.1 0.2 0.3 0.2 0.6
Diabetes (father) 0.5 0.6 1.2 -0.1 1.1
Diabetes (mother) 0.4 0.5 0.9 -0.3 0.9
Severe depression (siblings) 0.7 0.8 1.4 -1.2 0.4
Pack years adult smoking proportion 0.0 0.1 0.1 0.3 0.1
Impedance of leg (right) 0.2 1.1 2.0 1.4 -0.4
Leg fat-free mass (left) 0.6 3.1 3.5 -1.9 1.6
Trunk fat percentage 0.0 0.2 0.2 -0.5 0.4
Hand grip strength (right) 0.6 1.5 2.3 -0.9 -1.5
Townsend deprivation index at recruitment 2.2 3.1 4.8 -2.2 1.2
Current tobacco smoking 1.0 1.6 2.2 1.5 -1.0
Average weekly fortified wine intake 0.1 0.2 0.3 -0.1 -0.6
Maternal smoking around birth 0.1 0.2 0.2 0.3 0.5
Fed-up feelings 1.2 2.2 3.5 1.9 -0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.4 2.8 0.0 -1.7
Relative age voice broke 0.1 0.1 0.2 -0.4 -0.3
Taking other prescription medications 0.4 0.6 1.2 1.1 -0.1
Age when periods started (menarche) 0.0 0.0 0.0 0.1 0.1
Bilateral oophorectomy (both ovaries removed) 1.4 1.6 2.3 1.5 -1.0
Heel bone mineral density (BMD) T-score, automated (left) 0.4 1.0 1.9 0.2 -1.4
Tinnitus: Yes, but not now, but have in the past 1.8 2.0 3.7 -1.9 -0.5
Qualifications: CSEs or equivalent 0.1 0.1 0.1 -0.2 0.3
Serious illness, injury or assault to yourself 1.9 2.3 3.1 -1.8 1.2
High blood pressure 1.2 3.3 5.0 -1.3 2.2
Hayfever, allergic rhinitis or eczema 1.3 2.8 3.1 1.6 -1.8
Multivitamins +/- minerals 0.2 0.2 0.4 -0.1 0.6
Stomach or abdominal pain in last month 1.1 1.4 2.6 0.5 -1.6
Supplements: Glucosamine 0.2 0.3 0.4 0.6 -0.4
Diverticular disease/diverticulitis (self-reported) 0.0 0.0 0.0 -0.2 -0.2
Medication: Atenolol 0.4 0.5 1.0 -1.0 -0.2
Medication: Levothyroxine sodium 4.8 8.1 15.8 4.0 -0.7
Sitting height 0.3 1.9 3.7 -0.3 1.9
Chronic bronchitis/emphysema (father) 0.6 0.7 0.9 -0.9 0.8
High blood pressure (mother) 1.3 1.9 2.7 -1.6 1.0
Body mass index (BMI) 0.0 0.2 0.4 -0.6 0.2
Impedance of leg (left) 0.4 1.8 3.4 1.8 -0.5
Leg predicted mass (left) 0.6 3.3 3.7 -1.9 1.7
Trunk fat mass 0.1 0.4 0.5 -0.6 0.7
Waist circumference 0.2 0.8 1.2 -0.6 1.1
Number of incorrect matches in round 0.0 0.0 0.0 0.1 -0.1
Past tobacco smoking 0.6 1.1 2.1 -0.5 -1.4
Alcohol usually taken with meals 1.2 2.0 2.6 1.6 -1.2
Nervous feelings 1.3 2.4 4.5 0.5 -2.1
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 1.5 -0.3 -1.2
Hearing difficulty/problems with background noise 0.2 0.4 0.7 -0.9 -0.1
Hair/balding pattern: Pattern 2 1.4 1.7 2.7 0.9 -1.6
Had menopause 0.7 0.8 1.1 0.8 1.0
Had other major operations 1.9 2.3 4.3 -0.6 2.1
Forced vital capacity (FVC) 0.0 0.0 0.0 -0.0 -0.1
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.2 4.1 0.5 -2.0
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 0.9 -1.0 -0.0
Qualifications: None of the above 0.3 0.7 1.0 1.0 0.7
Financial difficulties in last 2 years 0.1 0.2 0.3 0.6 0.2
Mouth/teeth dental problems 2.5 3.8 6.1 2.5 -1.3
Heart attack 0.0 0.1 0.1 -0.1 0.3
Allergy 0.7 1.5 1.8 -1.1 1.3
Pain all over the body in last month 0.4 0.4 0.8 -0.2 0.9
Diabetes (self-reported) 0.2 0.3 0.4 0.4 0.7
Hayfever/allergic rhinitis (self-reported) 0.8 1.0 1.5 -1.2 0.7
Medication: Ramipril 2.3 3.0 4.2 -2.1 1.3
Medication: Simvastatin 0.6 0.8 1.4 1.2 0.5
Fluid intelligence score 0.7 1.5 2.7 -0.5 -1.6
Illnesses of siblings 1.0 1.4 2.7 -1.6 -0.2
Neuroticism score 1.0 2.2 3.7 0.8 -1.9
Weight 0.3 1.3 1.7 -0.9 1.3
Impedance of arm (right) 0.0 0.0 0.1 -0.2 -0.1
Arm fat percentage (right) 0.2 0.7 1.2 -1.1 0.4
Trunk fat-free mass 0.4 2.3 3.3 -1.1 1.8
Hip circumference 0.0 0.1 0.2 -0.4 -0.2
Time employed in main current job 0.4 0.5 0.8 0.9 -0.5
Alcohol intake versus 10 years previously 1.0 1.5 2.6 -0.7 1.6
Father’s age at death 1.5 2.0 3.6 0.6 -1.9
Worrier / anxious feelings 2.9 5.5 7.4 1.9 -2.7
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.3 1.9 0.9 -1.4
Falls in the last year 0.8 1.1 1.5 -0.8 1.2
Hair/balding pattern: Pattern 3 0.8 1.2 2.1 0.4 1.5
Number of live births 0.4 0.5 0.9 -0.9 0.3
Forced expiratory volume in 1-second (FEV1) 0.1 0.4 0.9 0.9 0.2
Pulse rate 0.0 0.0 0.0 -0.2 0.2
Happiness 0.6 0.7 0.9 0.7 -1.0
Noisy workplace 0.7 0.8 1.0 -1.0 0.9
Qualifications: A levels/AS levels or equivalent 0.5 1.1 1.9 -1.4 -0.6
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 0.8 0.9 0.5
Mouth/teeth dental problems: Dentures 0.7 1.2 1.4 -1.0 1.2
Asthma 0.6 1.2 1.7 0.8 -1.3
Medication: Ibuprofen (e.g. Nurofen) 1.9 2.4 3.3 1.8 -1.2
Medication: Cholesterol lowering 0.4 0.7 1.3 1.1 -0.2
Depression (self-reported) 1.2 1.4 1.8 -1.0 1.4
Medication: Lansoprazole 0.0 0.0 0.0 -0.1 0.1
Prospective memory result 0.1 0.1 0.2 -0.3 0.4
Lung cancer (father) 0.9 1.0 1.9 -0.3 1.4
Illnesses of mother 2.8 3.4 5.4 1.2 -2.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.0 0.0 0.0 0.1 0.1
Pulse wave Arterial Stiffness index 2.3 2.7 4.0 -1.2 2.0
Impedance of arm (left) 0.1 0.2 0.4 0.3 -0.6
Arm fat mass (right) 0.1 0.5 0.9 -0.9 0.5
Trunk predicted mass 0.4 2.5 3.5 -1.3 1.9
Standing height 0.3 2.9 5.3 -0.7 2.3
Length of working week for main job 0.5 0.6 1.1 1.0 0.3
Exposure to tobacco smoke at home 1.8 2.0 3.0 -1.7 -1.0
Breastfed as a baby 0.0 0.0 0.0 0.2 -0.1
Tense / ‘highly strung’ 0.1 0.2 0.2 -0.3 -0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 3.1 4.8 7.7 1.4 -2.8
Hair/balding pattern: Pattern 4 0.1 0.3 0.7 0.0 0.8
Birth weight of first child 1.9 3.4 5.0 1.4 -2.2
Peak expiratory flow (PEF) 0.8 1.9 3.7 1.9 0.0
Pulse wave reflection index 0.4 0.6 1.1 -0.1 1.0
Ever highly irritable/argumentative for 2 days 0.0 0.0 0.1 -0.1 -0.2
Loud music exposure frequency 0.3 0.3 0.6 -0.0 -0.8
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.6 0.0 -0.8
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 0.5 -0.7 0.1
Blood clot in the leg (DVT) 0.6 0.7 1.4 1.2 -0.1
Medication: Paracetamol 0.3 0.4 0.7 -0.9 0.4
Headache pain in last month 1.2 2.1 4.2 -2.1 0.2
Medication for cholesterol, blood pressure or diabetes 0.1 0.1 0.1 -0.3 -0.3
Glaucoma (self-reported) 3.6 4.2 8.2 2.9 -0.4
Gout (self-reported) 0.1 0.2 0.3 0.1 -0.6
Hypothyroidism/myxoedema (self-reported) 4.2 8.3 15.6 3.9 -1.0
Medication: Amlodipine 2.6 3.6 4.2 -2.1 1.7
Medication: Ventolin 100micrograms inhaler 3.0 3.8 7.5 -0.3 -2.7
Birth weight 0.4 0.8 1.0 1.0 0.7
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.2 0.5 -0.0
High blood pressure (siblings) 0.2 0.2 0.4 0.6 0.3
Forced vital capacity (FVC), Best measure 0.0 0.1 0.2 -0.5 0.2
Body fat percentage 0.0 0.1 0.1 -0.2 0.3
Leg fat percentage (right) 0.0 0.0 0.0 0.2 0.1
Arm fat-free mass (right) 0.1 0.6 1.0 -0.4 1.0
Exposure to tobacco smoke outside home 5.5 7.4 7.8 -2.8 2.6
Comparative body size at age 10 0.8 2.3 4.1 2.0 -0.6
Number of full brothers 1.9 2.4 4.6 -2.1 0.4
Worry too long after embarrassment 0.3 0.5 0.8 0.5 -0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 1.0 -0.5 -1.0
Wheeze or whistling in the chest in last year 0.3 0.5 1.0 -0.3 -1.0
Number of children fathered 3.2 3.6 6.9 2.6 -0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.1 -0.4 -0.4
Age at first live birth 0.5 0.9 1.5 -0.6 -1.2
Pulse wave peak to peak time 1.3 1.6 2.5 0.8 -1.6
Health satisfaction 1.2 1.5 3.0 1.7 -0.3
Shortness of breath walking on level ground 0.9 1.0 1.5 1.2 -0.7
Qualifications: College or University degree 0.9 2.8 4.9 -2.2 0.9
Eye problems/disorders: None of the above 0.5 0.6 1.0 -1.0 0.4
Mouth/teeth dental problems: Loose teeth 1.1 1.4 2.7 -0.0 1.6
Emphysema/chronic bronchitis 1.1 1.2 1.9 -1.4 0.7
Medication for pain relief, constipation, heartburn 0.3 0.5 0.9 -1.0 0.2
Neck or shoulder pain in last month 0.7 1.0 1.9 1.4 -0.3
Medication: Blood pressure 0.3 0.5 0.6 -0.8 0.5
Angina (self-reported) 0.4 0.5 0.8 -0.9 0.6
Migraine (self-reported) 0.7 0.9 1.4 -1.2 0.7
Medication: Ibuprofen 1.3 1.5 2.1 1.5 -0.9
Medication: Allopurinol 0.3 0.3 0.5 -0.7 -0.4
Medication: Omeprazole 0.1 0.1 0.1 0.3 -0.3
Medication: Seretide 50 evohaler 0.0 0.0 0.0 -0.1 -0.1
Mean time to correctly identify matches 0.1 0.1 0.2 -0.4 0.4
Heart disease (mother) 0.7 0.8 1.6 0.2 1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.3 1.6 2.9 1.7 0.4
Whole body fat mass 0.1 0.2 0.3 -0.3 0.6
Leg fat mass (right) 0.0 0.1 0.2 -0.2 0.4
Arm predicted mass (right) 0.1 0.6 1.1 -0.2 1.1
Pulse rate, automated reading 0.8 2.5 3.4 -1.3 1.8
Alcohol intake frequency. 0.8 1.9 2.1 -1.3 1.5
Comparative height size at age 10 0.0 0.3 0.3 0.4 0.6
Number of full sisters 2.0 2.4 3.0 -1.3 1.7
Suffer from ‘nerves’ 0.2 0.2 0.4 -0.3 -0.6
Overall health rating 0.1 0.3 0.5 0.7 0.2
Chest pain or discomfort 0.1 0.1 0.2 -0.5 -0.1
Had major operations 0.1 0.2 0.3 0.6 0.2
Age at last live birth 0.5 0.8 1.4 -1.2 0.4
Family relationship satisfaction 0.2 0.2 0.3 -0.6 0.3
Leg pain on walking 0.2 0.3 0.5 -0.1 -0.7
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.2 0.2 -0.4
Commuting to job workplace: Car/motor vehicle 0.1 0.2 0.2 0.5 -0.3
Illness, injury, bereavement, stress in last 2 years 0.7 0.8 1.6 1.2 -0.4
Medication: Aspirin 1.1 1.4 2.7 0.3 1.7
Supplements: Vitamin C 0.2 0.2 0.4 -0.2 0.6
Knee pain experienced in last month 0.4 0.6 1.2 0.0 1.1
Hypertension (Self-reported) 1.1 3.1 4.9 -1.1 2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 0.7 -0.8 0.8
Illnesses of father: Heart disease 0.7 1.0 1.4 -0.8 -1.2
Illnesses of siblings: Diabetes 0.8 0.9 1.7 0.4 1.3
Smoking status: Previous 0.7 1.0 2.0 -0.0 1.4
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 1.1 0.0 1.1
Whole body fat-free mass 0.5 2.7 3.4 -1.4 1.9
Leg fat-free mass (right) 0.5 2.9 3.0 -1.7 1.7
Arm fat percentage (left) 0.1 0.2 0.4 -0.6 -0.0
Average weekly red wine intake 0.0 0.0 0.1 0.3 -0.1
Handedness (chirality/laterality): Left-handed 0.5 0.6 0.7 -0.8 0.8
Mood swings 0.6 1.1 1.3 1.1 -1.0
Loneliness, isolation 1.9 2.6 3.3 1.4 -1.8
Long-standing illness, disability or infirmity 0.4 0.7 1.3 1.1 -0.0
Ever had bowel cancer screening 1.3 1.5 2.1 1.0 -1.5
Diabetes diagnosed by doctor 0.2 0.3 0.5 -0.1 0.7
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.3 1.5 1.0 1.2
Friendships satisfaction 0.0 0.0 0.0 -0.0 0.0
Qualifications: nursing, teaching 0.3 0.4 0.6 -0.8 -0.5
Commuting to job workplace: Walk 0.8 0.8 1.6 -0.1 -1.3
Eye problems/disorders: Cataract 2.7 3.1 5.2 2.3 -1.0
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 1.2 -1.1 0.4
Medication for cholesterol 2.2 3.3 5.4 1.1 -2.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.1 1.5 0.9 -1.2
Back pain experienced in last month 3.0 4.4 8.8 3.0 -0.0
Mineral and other dietary supplements 0.1 0.2 0.4 -0.6 0.2
Breast cancer (self-reported) 0.3 0.3 0.5 0.2 -0.7
Asthma (self-reported) 0.5 1.0 1.5 0.6 -1.2
Osteoporosis (self-reported) 0.4 0.5 0.9 -0.4 0.9
Osteoarthritis (self-reported) 0.7 1.0 1.1 0.9 1.0
Medication: Aspirin 2.4 3.1 6.1 -0.3 2.5
Medication: Gliclazide 0.0 0.0 0.1 0.2 -0.1
Illnesses of father: None of the above (group 1) 0.0 0.0 0.1 0.1 0.3
Smoking status: Current 0.9 1.4 1.9 1.4 -0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 0.6 0.4 -0.8
Whole body water mass 0.4 2.5 3.0 -1.4 1.7
Leg predicted mass (right) 0.6 3.1 3.3 -1.8 1.7
Arm fat mass (left) 0.1 0.2 0.4 -0.6 0.3
Number of self-reported non-cancer illnesses 0.8 1.4 2.9 -0.2 1.7
Average weekly champagne plus white wine intake 0.7 0.9 1.8 0.3 -1.3
Miserableness 1.0 1.8 3.6 -0.0 -1.9
Guilty feelings 0.6 0.9 1.4 0.6 -1.2
Wears glasses or contact lenses 0.4 0.4 0.8 0.3 0.9
Ever taken oral contraceptive pill 0.3 0.3 0.5 -0.7 0.4
Hearing aid user 0.2 0.3 0.3 0.6 -0.5
Mother’s age at death 0.7 0.9 1.8 1.3 -0.0
Financial situation satisfaction 0.8 0.9 1.1 0.9 -1.0
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.1 0.2 0.3
Commuting to job workplace: Public transport 0.2 0.2 0.4 -0.2 0.6
Eye problems/disorders: Glaucoma 3.2 3.7 7.5 2.7 -0.1
Medication: Blood pressure 1.8 3.4 5.0 -1.3 2.2
Pain type(s) experienced in last month: Hip pain 4.5 5.7 7.0 2.6 -2.1
Supplements: Fish oil (including cod liver oil) 0.1 0.1 0.1 0.4 -0.4
High cholesterol (Self-reported) 0.7 1.3 1.4 1.2 1.1
Medication: Bendroflumethiazide 0.9 1.3 1.5 -1.2 1.1
Medication: Paracetamol 0.1 0.1 0.2 0.1 0.5
Medication: Lisinopril 0.7 0.9 1.7 0.1 1.3
Medication: Atorvastatin 0.2 0.3 0.6 -0.0 0.8
Illnesses of father: High blood pressure 1.4 1.8 3.2 1.8 -0.6
Alcohol drinker status: Never 0.1 0.1 0.1 0.4 0.4
Ever smoked 0.3 0.5 0.9 1.0 0.4
Basal metabolic rate 0.5 2.7 3.4 -1.4 1.8
Leg fat percentage (left) 0.0 0.1 0.2 0.4 -0.0
Arm fat-free mass (left) 0.3 1.4 2.5 -0.6 1.6
Number of operations (self-reported) 0.6 0.9 1.8 0.3 -1.3
Average weekly beer plus cider intake 0.5 0.8 1.5 -1.2 0.0
Irritability 0.2 0.3 0.6 0.2 0.8
Risk taking 3.0 4.3 5.7 -1.7 2.4
Ever had prostate specific antigen (PSA) test 3.8 4.3 6.9 2.6 -1.3
Fractured/broken bones in last 5 years 0.2 0.3 0.3 -0.6 0.5
Age started oral contraceptive pill 0.5 0.6 1.2 -1.1 -0.2
Diastolic blood pressure, automated reading 6.1 19.0 19.8 -4.3 4.5
Ever depressed for a whole week 0.6 0.8 1.5 -1.2 -0.2
Unable to work because of sickness or disability 0.6 0.8 1.5 0.3 -1.2
Commuting to job workplace: Cycle 0.2 0.3 0.5 -0.7 0.2
Myopia 1.4 2.0 3.8 -2.0 0.3
Vascular/heart problems diagnosed by doctor 0.9 2.4 4.0 0.9 -2.0
Cholesterol lowering medication 2.6 3.9 7.4 -0.6 2.7
Medication: Omeprazole (e.g. Zanprol) 0.0 0.0 0.1 0.1 -0.3
Pain experienced in last month 0.6 1.0 1.9 -1.4 0.4
Supplements: Calcium 1.5 1.6 1.7 1.3 -1.3
Basal cell carcinoma (self-reported) 6.3 7.4 9.9 -2.2 3.2
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.4 -0.5 0.6
Deep venous thrombosis (DVT) (self-reported) 0.6 0.7 1.3 1.2 0.3
Heart disease (siblings) 1.0 1.3 2.3 0.4 1.5
Alcohol drinker status: Previous 1.4 1.6 1.9 -1.1 1.4
Pack years of smoking 0.0 0.1 0.1 0.4 0.1
Impedance of whole body 0.0 0.3 0.4 0.6 -0.4
Leg fat mass (left) 0.0 0.1 0.1 -0.1 0.4
Arm predicted mass (left) 0.3 1.3 2.2 -0.7 1.5