[Hub]/) : Traits : Crohns Disease (2017) : ← →

chr2:24,324,172-25,837,917

Best TWAS P=1e-13 · Best GWAS P=2.65e-11 conditioned to 0.884

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ADCY3	0.16	0.12	lasso	10	0.14	3.2e-17	6.5	-7.4	1.0e-13	-0.89	0.01	0.99	TRUE
6	GTEx	Nerve Tibial	ADCY3	0.09	0.05	enet	6	0.03	2.2e-03	5.0	-6.7	2.4e-11	-0.92	0.02	0.98	FALSE
11	YFS	Blood	ADCY3	0.07	0.02	bslmm	343	0.04	7.3e-14	6.6	-6.5	5.8e-11	-0.63	0.00	1.00	FALSE
7	GTEx	Nerve Tibial	RP11-443B20.1	0.07	0.03	enet	6	0.02	1.1e-02	5.0	-6.2	7.8e-10	-0.82	0.03	0.96	FALSE
4	GTEx	Artery Tibial	RP11-443B20.1	0.17	0.08	enet	40	0.09	8.2e-08	5.0	6.0	1.4e-09	0.59	0.54	0.42	FALSE
9	GTEx	Whole Blood	RP11-443B20.1	0.21	0.17	enet	32	0.20	1.8e-18	4.8	6.0	2.1e-09	0.87	0.76	0.24	FALSE
8	GTEx	Whole Blood	ADCY3	0.23	0.24	enet	24	0.27	5.5e-25	5.3	5.9	3.7e-09	0.87	0.96	0.04	FALSE
10	ROSMAP	Brain Pre-frontal Cortex	ADCY3	0.17	0.26	enet	32	0.26	6.8e-33	5.3	-5.8	5.8e-09	-0.90	0.88	0.12	FALSE
3	GTEx	Artery Tibial	ADCY3	0.21	0.14	lasso	6	0.15	4.3e-12	5.0	5.7	1.0e-08	0.70	0.98	0.02	FALSE
5	GTEx	Cells EBV-transformed lymphocytes	RP11-443B20.1	0.13	0.13	enet	9	0.05	9.2e-03	4.7	-5.6	2.7e-08	-0.93	0.02	0.95	FALSE
2	CommonMind	Brain Pre-frontal Cortex	CENPO	0.07	0.03	bslmm	322	0.03	7.0e-05	4.0	-5.5	4.0e-08	-0.49	0.49	0.23	FALSE
12	The Cancer Genome Atlas	Breast Invasive Carcinoma	ADCY3	0.05	0.03	blup	81	0.03	5.0e-07	2.4	-5.3	1.5e-07	-0.51	0.58	0.38	FALSE