Best TWAS P=1e-13 · Best GWAS P=2.65e-11 conditioned to 0.884
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ADCY3 | 0.16 | 0.12 | lasso | 10 | 0.14 | 3.2e-17 | 6.5 | -7.4 | 1.0e-13 | -0.89 | 0.01 | 0.99 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | CENPO | 0.07 | 0.03 | bslmm | 322 | 0.03 | 7.0e-05 | 4.0 | -5.5 | 4.0e-08 | -0.49 | 0.49 | 0.23 | FALSE |
| 3 | GTEx | Artery Tibial | ADCY3 | 0.21 | 0.14 | lasso | 6 | 0.15 | 4.3e-12 | 5.0 | 5.7 | 1.0e-08 | 0.70 | 0.98 | 0.02 | FALSE |
| 4 | GTEx | Artery Tibial | RP11-443B20.1 | 0.17 | 0.08 | enet | 40 | 0.09 | 8.2e-08 | 5.0 | 6.0 | 1.4e-09 | 0.59 | 0.54 | 0.42 | FALSE |
| 5 | GTEx | Cells EBV-transformed lymphocytes | RP11-443B20.1 | 0.13 | 0.13 | enet | 9 | 0.05 | 9.2e-03 | 4.7 | -5.6 | 2.7e-08 | -0.93 | 0.02 | 0.95 | FALSE |
| 6 | GTEx | Nerve Tibial | ADCY3 | 0.09 | 0.05 | enet | 6 | 0.03 | 2.2e-03 | 5.0 | -6.7 | 2.4e-11 | -0.92 | 0.02 | 0.98 | FALSE |
| 7 | GTEx | Nerve Tibial | RP11-443B20.1 | 0.07 | 0.03 | enet | 6 | 0.02 | 1.1e-02 | 5.0 | -6.2 | 7.8e-10 | -0.82 | 0.03 | 0.96 | FALSE |
| 8 | GTEx | Whole Blood | ADCY3 | 0.23 | 0.24 | enet | 24 | 0.27 | 5.5e-25 | 5.3 | 5.9 | 3.7e-09 | 0.87 | 0.96 | 0.04 | FALSE |
| 9 | GTEx | Whole Blood | RP11-443B20.1 | 0.21 | 0.17 | enet | 32 | 0.20 | 1.8e-18 | 4.8 | 6.0 | 2.1e-09 | 0.87 | 0.76 | 0.24 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | ADCY3 | 0.17 | 0.26 | enet | 32 | 0.26 | 6.8e-33 | 5.3 | -5.8 | 5.8e-09 | -0.90 | 0.88 | 0.12 | FALSE |
| 11 | YFS | Blood | ADCY3 | 0.07 | 0.02 | bslmm | 343 | 0.04 | 7.3e-14 | 6.6 | -6.5 | 5.8e-11 | -0.63 | 0.00 | 1.00 | FALSE |
| 12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ADCY3 | 0.05 | 0.03 | blup | 81 | 0.03 | 5.0e-07 | 2.4 | -5.3 | 1.5e-07 | -0.51 | 0.58 | 0.38 | FALSE |