Best TWAS P=5.2e-12 · Best GWAS P=6.32e-11 conditioned to 0.974
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3 | GTEx | Lung | RP11-373D23.3 | 0.08 | 0.00 | enet | 21 | 0.02 | 2.3e-02 | -2.2 | 6.9 | 5.2e-12 | 0.23 | 0.07 | 0.69 | TRUE |
| 4 | GTEx | Testis | AC074117.10 | 0.14 | 0.08 | lasso | 6 | 0.12 | 4.5e-06 | -4.3 | 5.8 | 5.7e-09 | 0.85 | 0.04 | 0.96 | TRUE |
| 1 | GTEx | Artery Aorta | RP11-373D23.3 | 0.23 | 0.12 | enet | 12 | 0.06 | 2.5e-04 | -6.5 | 6.7 | 1.7e-11 | 0.06 | 0.01 | 0.98 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | FNDC4 | 0.13 | 0.06 | lasso | 2 | 0.05 | 1.1e-03 | 6.5 | -6.6 | 4.2e-11 | -0.99 | 0.00 | 0.95 | FALSE |
| 5 | GTEx | Thyroid | RP11-373D23.3 | 0.16 | 0.07 | enet | 19 | 0.04 | 2.6e-04 | -6.4 | 6.5 | 1.0e-10 | 0.15 | 0.01 | 0.98 | FALSE |
| 2 | GTEx | Esophagus Gastroesophageal Junction | RP11-373D23.3 | 0.17 | 0.01 | enet | 15 | 0.04 | 1.2e-02 | -6.4 | 6.3 | 2.4e-10 | 0.28 | 0.03 | 0.73 | FALSE |