TWAS hub - CENPO

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0740	0.0330	1.8e-03	0.035	0.025	0.030	0.032	0.030	3.9e-05	4.8e-04	1.3e-04	7.0e-05	1.1e-04
2	ROSMAP	Brain Pre-frontal Cortex	0.0838	0.0268	2.8e-06	0.039	0.042	0.052	0.045	0.049	7.6e-06	3.2e-06	2.6e-07	1.6e-06	6.1e-07
3	YFS	Blood	0.0886	0.0221	0.0e+00	0.065	0.065	0.066	0.066	0.067	2.7e-20	1.7e-20	1.1e-20	7.7e-21	6.7e-21

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Comparative body size at age 10	62.4	172.4	380.2	-19.5	-10.7	-4.7
Arm fat percentage (right)	16.3	64.4	141.6	-11.9	-7.0	-1.4
Arm fat percentage (left)	16.0	63.7	141.6	-11.9	-6.8	-1.6
BMI	15.4	89.5	179.6	-13.4	-8.7	-3.5
Sitting height	15.1	107.4	222.0	14.9	9.7	2.4
Leg fat percentage (left)	14.4	52.1	116.6	-10.8	-6.1	-1.4
Body mass index (BMI)	13.8	58.8	123.2	-11.1	-7.1	-1.8
Leg fat percentage (right)	13.7	49.7	112.4	-10.6	-5.9	-1.4
Standing height	13.5	134.4	234.1	15.3	10.0	8.3
Height	12.8	246.8	428.5	20.7	13.9	10.9
Body fat percentage	11.3	44.5	104.0	-10.2	-5.4	-0.7
Comparative height size at age 10	10.1	55.8	73.8	7.1	6.5	8.6
Forced vital capacity (FVC)	9.3	36.0	58.5	7.7	4.3	5.5
Arm fat mass (right)	8.9	36.8	80.1	-8.9	-5.5	0.1
Arm fat mass (left)	8.9	36.4	79.2	-8.9	-5.5	0.0
Hand grip strength (left)	8.6	22.8	50.8	7.1	2.7	3.2
Leg fat mass (left)	8.1	31.7	71.4	-8.4	-4.8	-0.3
Trunk fat percentage	8.0	32.2	76.6	-8.8	-4.5	0.1
Leg fat mass (right)	7.9	30.7	69.7	-8.3	-4.7	-0.2
Hand grip strength (right)	7.5	20.4	48.7	7.0	2.3	2.7
Forced vital capacity (FVC), Best measure	7.2	26.3	45.4	6.7	3.9	4.2
Crohns Disease (2017)	7.0	15.3	30.1	-5.5	-3.2	-2.3
Irritable Bowel Disease (IBD)	6.6	15.7	34.3	-5.9	-2.7	-2.3
Whole body fat mass	6.2	25.8	58.4	-7.6	-4.3	0.3
Breast Cancer	6.1	14.7	28.4	-5.3	-3.7	-1.4
Medication: Omeprazole	6.1	7.3	8.3	2.3	2.9	2.9
Medication: Omeprazole (e.g. Zanprol)	5.7	6.9	11.8	2.1	2.2	3.4
Body Mass Index (BMI) (2010)	5.6	7.7	11.4	-3.4	-2.7	-2.1
Systolic Blood Pressure	5.6	28.0	34.2	5.2	4.7	5.8
Waist circumference	5.5	19.9	45.6	-6.8	-3.6	1.3
Time employed in main current job	5.5	6.4	14.4	2.1	3.8	-0.5
Forced expiratory volume in 1-second (FEV1)	4.6	15.6	21.8	4.7	2.5	4.3
Hypertension (Self-reported)	4.5	12.4	34.3	0.3	1.7	5.9
Trunk fat mass	4.4	18.9	43.8	-6.6	-3.5	1.0
High blood pressure	4.2	11.7	31.6	0.1	1.9	5.6
Hip circumference	4.2	18.0	39.6	-6.3	-3.8	-0.6
Medication: Lisinopril	4.2	5.5	7.7	2.0	2.1	2.8
Crohns Disease (2012)	4.1	6.6	10.7	-2.6	-3.3	-1.4
Mean time to correctly identify matches	4.1	7.9	17.0	4.1	2.5	-0.4
Hearing aid user	4.1	4.7	7.9	-2.5	-2.8	-0.2
Lung FEV1/FVC ratio	3.9	19.8	44.1	-6.6	-3.2	-2.2
Forced expiratory volume in 1-second (FEV1), predicted	3.8	8.0	14.5	3.8	2.6	1.6
Age when periods started (menarche)	3.7	8.9	23.4	4.8	1.6	0.9
Medication: Blood pressure	3.7	6.5	14.4	1.7	1.4	3.8
Vitamin and mineral supplements	3.5	4.7	13.2	-3.6	-0.8	0.6
Medication: Metformin	3.5	4.9	11.0	-3.3	-1.8	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	3.5	11.0	15.4	3.9	2.5	3.4
Reason for reducing amount of alcohol drunk: Health precaution	3.3	3.9	8.4	2.9	0.6	1.7
Medication: Blood pressure	3.3	6.2	18.0	-0.1	0.9	4.2
Waist Hip Ratio (WHR)	3.2	14.3	33.6	2.2	2.1	5.8
Multivitamins +/- minerals	3.2	4.1	10.4	3.2	1.4	-0.0
Reaction Time	3.1	5.9	15.7	4.0	1.4	-0.3
Medication: Atenolol	3.1	3.9	10.3	-0.9	-0.7	3.2
Medication: Ramipril	3.1	4.0	9.4	-1.1	-1.1	3.1
Trunk predicted mass	3.1	17.7	27.0	5.2	2.1	4.7
HDL Cholesterol	3.0	4.9	13.2	3.6	1.1	0.5
Supplements: Zinc	3.0	3.2	4.3	2.1	1.4	-1.8
Trunk fat-free mass	3.0	17.3	26.5	5.2	2.1	4.6
Ulcerative Colitis (UC)	2.9	5.4	14.2	-3.8	-0.9	-1.1
Number of incorrect matches in round	2.9	4.9	8.6	2.9	2.0	1.4
Illnesses of father: High blood pressure	2.9	3.6	10.4	0.4	-0.3	3.2
Worrier / anxious feelings	2.8	5.2	11.7	3.4	1.9	-0.6
Medication: Ibuprofen (e.g. Nurofen)	2.8	3.6	7.5	0.7	-1.6	2.7
HbA1C	2.7	3.0	6.6	-1.3	-2.6	0.8
Systolic blood pressure, automated reading	2.7	7.8	20.5	1.2	1.3	4.5
Diabetes (father)	2.7	3.3	6.8	1.6	-0.8	2.6
Birth weight of first child	2.7	4.9	5.6	2.3	1.9	2.4
Vascular/heart problems diagnosed by doctor	2.6	7.2	19.6	0.0	-1.4	-4.4
Peak expiratory flow (PEF)	2.5	5.8	6.2	2.3	2.4	2.5
Medication: Bendroflumethiazide	2.5	3.8	10.4	-0.7	0.7	3.2
Medication for pain relief, constipation, heartburn	2.4	4.1	9.0	-1.7	0.6	-3.0
Medication: Ibuprofen	2.4	2.9	6.0	0.8	-1.4	2.5
Cardiovascular Disease	2.3	7.7	21.5	-0.1	1.3	4.6
Worry (Nagel 2018)	2.2	4.7	9.4	3.1	2.1	-0.3
Neuroticism (2016)	2.2	3.2	7.8	1.2	2.8	0.6
Hearing difficulty/problems: Yes	2.2	3.3	6.5	-1.8	-2.6	0.3
Blood White Count	2.1	15.4	35.4	-6.0	-3.3	-0.3
Impedance of leg (right)	2.1	10.1	12.2	3.5	3.5	2.4
Qualifications: CSEs or equivalent	2.1	2.8	4.7	-1.8	-2.2	0.8
Birth weight	2.1	4.5	9.5	0.4	2.0	3.1
Mouth/teeth dental problems: Loose teeth	2.1	2.5	6.4	-1.1	-2.5	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.1	2.5	7.1	0.6	2.7	-0.1
Medication: Aspirin	2.1	2.7	4.9	1.6	2.2	0.8
Ulcerative Colitis	2.0	2.9	7.6	-2.8	-0.6	-0.9
Ever used hormone-replacement therapy (HRT)	2.0	2.5	3.4	1.7	1.1	1.8
Severe depression (siblings)	2.0	2.2	3.3	-1.7	-1.8	-0.5
Hearing difficulty/problems with background noise	2.0	3.2	5.7	-1.5	-2.4	1.3
Ever depressed for a whole week	2.0	2.5	5.2	0.2	2.3	-1.5
Prostate Cancer	1.9	2.7	4.7	-2.2	-1.8	-0.4
Family relationship satisfaction	1.9	2.3	4.8	2.2	1.5	0.1
Osteoarthritis (self-reported)	1.9	2.4	4.1	-2.0	-1.4	1.1
Verbal and Numeric Reasoning (VNR)	1.8	4.2	10.8	-3.3	-0.8	-1.1
Medication for hormone replacement therapy	1.8	2.0	3.5	1.9	-0.9	1.4
Impedance of leg (left)	1.8	8.9	11.6	3.4	3.2	2.2
Had major operations	1.8	2.2	5.2	2.3	0.6	-0.9
Medication: Aspirin	1.8	2.4	4.2	1.6	2.1	0.7
Supplements: Vitamin C	1.8	2.2	6.1	2.5	0.3	-0.6
Mother’s age at death	1.8	2.3	3.6	-1.8	0.1	-1.9
Pain type(s) experienced in last month: Hip pain	1.8	2.2	2.6	-1.3	-1.5	1.6
Risk taking	1.8	2.6	6.4	2.5	1.2	-0.3
Coronary Artery Disease (CAD)	1.7	2.0	5.2	-1.0	0.0	-2.3
Number of treatments/medications taken	1.7	3.0	5.9	1.3	-1.2	2.4
Diabetes (self-reported)	1.7	2.6	3.4	-1.3	-1.8	1.6
Breastfed as a baby	1.7	2.1	3.3	1.8	1.7	0.4
Long-standing illness, disability or infirmity	1.7	2.5	3.6	-1.9	-1.8	-0.7
Number of operations (self-reported)	1.7	2.5	3.9	1.7	0.8	2.0
Ever had prostate specific antigen (PSA) test	1.7	2.0	3.7	1.9	1.3	-0.7
Diastolic blood pressure, automated reading	1.7	5.3	13.9	1.0	-0.9	3.7
Pain all over the body in last month	1.6	1.7	5.1	0.3	-0.0	2.2
Hypothyroidism/myxoedema (self-reported)	1.6	3.2	7.6	-1.1	-2.8	-0.8
Arm fat-free mass (right)	1.6	8.1	11.9	3.3	1.4	3.5
Angina (self-reported)	1.6	2.1	3.3	-1.8	-1.3	-1.2
Medication: Seretide 50 evohaler	1.6	1.8	3.8	-1.3	-1.9	0.1
Medication for cholesterol	1.6	2.5	7.4	-0.0	-0.0	-2.7
Asthma (self-reported)	1.6	3.3	5.8	-2.4	-1.9	-0.7
Whole body water mass	1.6	8.8	13.8	3.4	1.2	3.7
Commuting to job workplace: Cycle	1.6	1.9	3.3	-1.8	-1.0	1.2
Arm predicted mass (left)	1.6	8.3	17.8	2.6	0.5	4.2
Alzheimer’s Disease (in father)	1.5	1.7	4.3	0.5	0.6	-2.1
Major Depression (MDD)	1.5	1.8	2.6	-1.0	1.3	-1.6
Lupus	1.5	2.2	4.3	2.1	-0.3	1.5
Diabetes (mother)	1.5	2.0	3.0	-1.7	-1.2	1.2
Lung cancer (father)	1.5	1.8	2.7	1.7	1.5	-0.5
Illnesses of mother	1.5	1.9	3.6	1.9	-0.2	-1.4
Wheeze or whistling in the chest in last year	1.5	2.6	4.1	-2.0	-1.6	1.1
Arm predicted mass (right)	1.5	7.7	12.1	3.0	1.3	3.5
Pulse rate, automated reading	1.5	4.8	11.2	1.1	-1.4	3.4
Whole body fat-free mass	1.5	8.7	12.5	3.5	1.3	3.5
Mineral and other dietary supplements	1.5	2.0	5.2	-2.3	-0.9	-0.4
Supplements: Fish oil (including cod liver oil)	1.5	2.0	3.6	1.9	1.5	-0.0
Unable to work because of sickness or disability	1.5	1.9	2.5	-1.3	-1.6	1.2
Blood Eosinophil Count	1.4	10.4	29.7	-5.5	-0.7	-1.1
Hypothyroidism (self reported)	1.4	3.1	4.7	-2.2	-2.1	0.2
Chronotype (morning person)	1.4	3.1	5.2	2.3	1.0	1.8
Angina	1.4	1.8	2.7	-1.6	-1.2	-1.1
Ever unenthusiastic/disinterested for a whole week	1.4	1.7	4.0	-1.1	2.0	-0.2
Weight	1.4	7.0	12.8	-3.6	-2.1	2.0
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.2	3.6	-1.9	-1.6	0.6
Medication: Lansoprazole	1.4	1.6	2.7	-1.2	-0.9	1.6
Loneliness, isolation	1.4	1.9	3.4	-1.9	-1.4	-0.5
Ever had bowel cancer screening	1.4	1.6	4.1	0.8	2.0	-0.2
Arm fat-free mass (left)	1.4	7.0	14.9	2.5	0.4	3.9
Impedance of whole body	1.4	7.2	10.7	3.0	3.3	1.4
Chronic bronchitis/emphysema (father)	1.3	1.5	3.5	0.1	1.9	-1.0
Medication: Amlodipine	1.3	1.8	4.9	-0.4	0.6	2.2
Number of full sisters	1.3	1.6	4.7	-0.1	-2.2	0.4
Medication: Atorvastatin	1.3	1.6	4.5	2.1	-0.2	-0.4
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	3.0	0.3	1.5	-1.7
Bipolar Disorder (2018)	1.2	1.9	2.6	-1.6	-1.1	1.4
Pack years adult smoking proportion	1.2	1.8	3.6	-1.3	-1.9	-0.4
Average weekly fortified wine intake	1.2	1.4	3.1	0.5	-1.8	-0.9
Asthma	1.2	2.3	4.4	-2.1	-1.5	-0.6
Blood clot in the leg (DVT)	1.2	1.6	3.8	0.2	0.9	-2.0
Medication: Paracetamol	1.2	1.9	4.0	0.3	-1.3	2.0
Suffer from ‘nerves’	1.2	1.9	4.0	0.9	2.0	0.9
Age at last live birth	1.2	1.7	2.7	1.4	1.6	-0.6
Medication: Paracetamol	1.2	1.8	4.0	-0.3	-1.1	2.0
Average weekly beer plus cider intake	1.2	1.7	4.0	-0.7	-2.0	-0.7
Triglycerides	1.1	1.7	4.4	-0.5	-0.7	2.1
Exposure to tobacco smoke at home	1.1	1.3	3.2	0.5	1.8	0.6
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	4.3	-1.1	-0.1	-2.1
High blood pressure (siblings)	1.1	1.6	1.7	1.2	1.3	1.3
Commuting to job workplace: Walk	1.1	1.1	2.3	0.0	1.5	-1.1
Eye problems/disorders: Cataract	1.1	1.3	2.7	0.8	1.6	0.7
Intelligence (Savage-Jansen 2018)	1.0	3.2	8.0	-2.8	-1.2	-0.1
Type 2 Diabetes (T2D) (2012)	1.0	1.1	2.7	0.8	-0.0	1.6
Type 2 Diabetes (T2D) (2018)	1.0	1.8	3.7	-1.0	-0.8	1.9
Taking other prescription medications	1.0	1.5	1.7	-1.3	-1.1	1.3
Hayfever, allergic rhinitis or eczema	1.0	2.1	5.4	-0.5	-2.3	-0.9
High blood pressure (mother)	1.0	1.4	2.7	-1.2	-0.4	1.6
Financial difficulties in last 2 years	1.0	1.3	2.6	-0.6	-1.6	1.1
Allergy	1.0	2.3	4.5	1.0	2.1	1.2
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.4	1.1	-0.7	1.5
Diabetes diagnosed by doctor	1.0	1.6	1.9	-1.2	-1.4	1.2
Friendships satisfaction	1.0	1.2	1.9	0.9	0.9	-1.4
Number of self-reported non-cancer illnesses	1.0	1.8	3.6	-0.3	-1.3	1.9
Mean Putamen Volume	0.9	1.0	1.8	-0.6	1.3	0.9
Blood Red Count	0.9	8.4	13.7	-3.3	-0.5	3.7
Sensitivity / hurt feelings	0.9	1.6	3.0	-1.2	-0.6	-1.7
Medication: Co-codamol	0.9	1.0	1.6	-0.3	-1.2	-1.3
Medication: Simvastatin	0.9	1.3	3.6	-0.5	0.1	1.9
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	1.7	-0.4	-1.3	-1.1
Mouth/teeth dental problems: Dentures	0.9	1.6	4.2	-2.0	0.7	0.1
Medication: Allopurinol	0.9	1.2	2.6	0.9	1.6	-0.6
Heart disease (mother)	0.9	1.1	2.3	-1.5	0.7	0.6
Knee pain experienced in last month	0.9	1.4	2.4	-0.2	-1.6	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	3.2	1.8	-0.0	0.3
Ever taken oral contraceptive pill	0.9	1.0	2.0	1.4	-0.5	0.8
Pack years of smoking	0.9	1.3	2.5	-1.1	-1.6	-0.4
Depression (Nagel 2018)	0.8	1.2	1.8	1.3	-0.5	1.4
Ovarian Cancer	0.8	1.0	2.7	0.3	-0.5	1.6
Primary Biliary Cirrhosis	0.8	1.1	2.8	-1.7	-0.7	-0.5
Allergy or Eczema	0.8	2.2	6.0	-0.6	-2.4	-0.5
Respiratory disease	0.8	1.8	3.0	-1.7	-1.4	-0.8
Frequency of depressed mood in last 2 weeks	0.8	1.1	3.0	0.3	0.3	1.7
Current tobacco smoking	0.8	1.3	3.5	-1.9	-0.6	-0.3
Medication: Levothyroxine sodium	0.8	1.4	2.9	-1.1	-1.7	0.2
Nervous feelings	0.8	1.5	3.5	1.9	0.9	-0.6
Had other major operations	0.8	0.9	1.7	-0.8	-0.6	1.3
Tense / ‘highly strung’	0.8	1.3	2.4	1.5	1.2	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	1.5	1.2	1.0	0.7
Average weekly red wine intake	0.8	1.2	1.9	1.4	1.4	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	1.6	1.3	-0.9	0.3
Osteoporosis (self-reported)	0.8	1.0	1.3	-1.0	-1.1	0.8
Medication: Gliclazide	0.8	0.9	1.5	-0.8	-1.2	0.7
Basal metabolic rate	0.8	4.3	10.3	1.5	0.3	3.2
Heart disease (siblings)	0.8	1.0	2.0	-1.4	-0.1	-1.1
Smoking Status	0.7	1.7	2.6	-1.6	-1.2	-1.0
Ever had hysterectomy (womb removed)	0.7	0.8	1.2	0.6	1.1	0.9
Stomach or abdominal pain in last month	0.7	0.9	1.4	0.8	-1.2	-0.8
Had menopause	0.7	0.9	2.6	-0.1	0.4	1.6
Mouth/teeth dental problems	0.7	1.0	2.7	1.6	0.3	-0.5
Fluid intelligence score	0.7	1.5	3.9	-2.0	-0.0	-0.8
Impedance of arm (left)	0.7	3.4	7.0	1.6	2.6	0.7
Pulse wave peak to peak time	0.7	0.8	2.2	0.3	1.5	0.3
Emphysema/chronic bronchitis	0.7	0.8	2.1	0.4	-1.5	0.4
Neck or shoulder pain in last month	0.7	0.9	2.5	-1.6	0.2	-0.5
Alcohol intake frequency.	0.7	1.6	3.5	-1.9	1.1	-0.4
Overall health rating	0.7	1.5	2.9	-1.7	-0.4	1.2
Smoking status: Current	0.7	1.1	3.0	-1.7	-0.3	-0.4
Miserableness	0.7	1.2	2.9	-1.7	-0.0	-0.9
Wears glasses or contact lenses	0.7	0.8	1.8	-0.5	-1.3	0.6
Cholesterol lowering medication	0.7	1.0	2.8	0.3	-0.1	1.7
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.9	0.9	-0.1	-1.4
Bipolar Disorder (2011)	0.6	0.6	1.8	0.1	-0.3	1.3
Fasting Glucose	0.6	0.8	1.0	1.0	1.0	-0.5
Lung FVC	0.6	3.0	4.1	2.0	-1.0	2.0
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.6	0.6	-0.4	1.2
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	2.2	0.1	0.6	1.5
Impedance of arm (right)	0.6	2.8	5.1	1.6	2.3	0.9
Health satisfaction	0.6	0.8	1.5	1.0	1.2	0.2
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.4	0.7	-0.4	1.5
Illnesses of father: None of the above (group 1)	0.6	0.7	1.5	-0.8	-0.1	-1.2
High cholesterol (Self-reported)	0.6	1.1	2.9	-0.5	0.1	1.7
Schizophrenia (2018)	0.5	1.0	2.2	1.5	-0.8	-0.4
Schizophrenia vs Biploar Disorder	0.5	0.7	1.0	0.5	-1.0	-0.9
Tanning	0.5	5.6	12.0	2.2	3.5	0.2
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	2.0	0.2	-0.3	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.1	0.9	0.4	1.0
Supplements: Glucosamine	0.5	0.6	1.4	1.2	-0.4	0.5
Heart attack	0.5	0.7	1.6	0.6	-0.3	-1.3
Depression (self-reported)	0.5	0.6	1.1	0.8	0.4	1.0
Prospective memory result	0.5	0.6	1.1	-0.9	-1.1	-0.0
Length of working week for main job	0.5	0.5	0.7	0.7	0.8	0.7
Number of full brothers	0.5	0.6	1.3	-1.2	-0.7	-0.0
Age at first live birth	0.5	0.8	1.8	1.3	0.8	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.4	-1.2	-0.5	0.5
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.6	-0.1	1.3	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.1	0.8	0.2	1.1
Handedness (chirality/laterality): Left-handed	0.5	0.5	1.4	0.3	0.3	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.9	0.2	0.1	1.7
Age at First Birth	0.4	0.6	1.6	0.2	0.2	-1.3
Townsend deprivation index at recruitment	0.4	0.5	0.6	-0.8	0.6	0.8
Qualifications: None of the above	0.4	0.8	1.4	1.2	0.9	-0.1
Falls in the last year	0.4	0.6	1.7	-1.3	0.3	0.3
Hair/balding pattern: Pattern 3	0.4	0.6	1.2	0.7	-0.2	1.1
Number of live births	0.4	0.5	1.2	-1.1	0.4	0.3
Noisy workplace	0.4	0.5	1.1	-0.1	-0.6	1.1
Medication: Cholesterol lowering	0.4	0.6	1.3	0.2	-0.6	1.1
Pulse wave Arterial Stiffness index	0.4	0.4	0.8	0.9	-0.7	0.3
Hair/balding pattern: Pattern 4	0.4	0.9	1.9	-1.4	-0.8	-0.5
Pulse wave reflection index	0.4	0.5	1.5	-0.1	-1.2	-0.2
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.0	-1.0	0.0	-0.7
Qualifications: nursing, teaching	0.4	0.6	0.8	-0.8	-0.9	0.4
Supplements: Calcium	0.4	0.4	1.3	1.1	-0.3	0.1
Bipolar Disorder or Schizophrenia	0.3	0.7	1.7	0.1	-1.3	0.6
Neuroticism (Nagel 2018)	0.3	0.7	1.1	1.1	1.0	-0.1
Blood Platelet Count	0.3	3.6	7.7	-1.7	0.1	-2.8
Heel T-Score	0.3	2.6	5.9	1.3	0.4	-2.4
Neuroticism	0.3	0.8	2.1	0.5	1.4	-0.2
Serious illness, injury or assault to yourself	0.3	0.4	1.0	1.0	-0.2	0.3
Hair/balding pattern: Pattern 2	0.3	0.3	0.7	-0.5	-0.8	0.3
Alcohol intake versus 10 years previously	0.3	0.4	0.9	0.3	0.4	-0.9
Father’s age at death	0.3	0.4	0.9	0.5	1.0	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.3	-1.2	0.4	0.2
Loud music exposure frequency	0.3	0.4	0.9	1.0	-0.4	0.2
Headache pain in last month	0.3	0.5	1.2	-1.1	-0.4	0.2
Gout (self-reported)	0.3	0.4	1.3	0.0	-0.1	-1.1
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.6	0.7	-0.0	0.8
Exposure to tobacco smoke outside home	0.3	0.4	0.6	-0.6	0.2	0.8
Worry too long after embarrassment	0.3	0.4	1.0	-1.0	-0.5	-0.2
Qualifications: College or University degree	0.3	1.0	2.3	0.2	-0.8	1.5
Migraine (self-reported)	0.3	0.3	0.7	-0.8	0.4	-0.3
Alcohol drinker status: Never	0.3	0.4	0.6	-0.2	0.8	-0.7
Fractured/broken bones in last 5 years	0.3	0.4	0.7	-0.8	0.2	0.8
Myopia	0.3	0.5	1.1	0.4	-1.1	0.3
Alzheimer’s Disease (including proxy)	0.2	0.3	0.8	0.9	0.0	-0.4
Hair Pigment	0.2	6.5	12.5	-3.5	0.8	-2.5
Average weekly spirits intake	0.2	0.2	0.4	0.3	-0.4	-0.6
Relative age of first facial hair	0.2	0.4	1.0	-0.3	-0.1	-1.0
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.5	-0.7	-0.4	0.0
Leg fat-free mass (left)	0.2	1.3	3.6	0.5	-0.0	1.9
Maternal smoking around birth	0.2	0.3	0.9	-0.1	1.0	0.3
Relative age voice broke	0.2	0.3	0.8	0.9	0.1	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.3	0.7	0.8	-0.3	-0.5
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.3	-0.5	-0.1	0.5
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.4	-0.7	-0.2	0.4
Leg predicted mass (left)	0.2	1.2	3.3	0.5	-0.0	1.8
Illnesses of siblings	0.2	0.2	0.6	0.8	-0.2	0.2
Pulse rate	0.2	0.4	1.1	-0.0	-0.3	1.0
Qualifications: A levels/AS levels or equivalent	0.2	0.5	0.7	0.9	0.7	0.6
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.5	-0.3	-0.7	-0.3
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.4	-0.6	-0.6	0.3
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.7	-0.8	0.1	0.0
Chest pain or discomfort	0.2	0.2	0.5	0.4	-0.7	0.1
Illnesses of father: Heart disease	0.2	0.3	0.8	-0.3	-0.9	-0.1
Leg fat-free mass (right)	0.2	1.2	2.8	0.9	0.0	1.7
Breast cancer (self-reported)	0.2	0.2	0.2	-0.5	-0.5	0.3
Leg predicted mass (right)	0.2	1.2	2.7	1.0	0.0	1.6
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.5	0.7	0.3	0.5
Commuting to job workplace: Public transport	0.2	0.3	0.3	-0.5	0.4	-0.6
Ever smoked	0.2	0.3	1.0	-0.0	-1.0	0.1
Irritability	0.2	0.3	0.7	-0.9	-0.2	-0.3
Age started oral contraceptive pill	0.2	0.2	0.3	-0.6	-0.3	-0.5
Basal cell carcinoma (self-reported)	0.2	0.2	0.4	0.5	0.1	-0.6
Alcohol drinker status: Previous	0.2	0.3	0.7	-0.2	-0.1	0.8
Depressed Affect (Nagel 2018)	0.1	0.1	0.3	-0.5	-0.1	-0.3
Alzheimer’s Disease (in mother)	0.1	0.1	0.3	-0.2	-0.0	0.5
LDL Cholesterol	0.1	0.1	0.2	-0.4	-0.0	0.2
Rheumatoid Arthritis	0.1	0.1	0.2	0.2	-0.3	-0.4
Schizophrenia (2014)	0.1	0.3	0.6	0.8	-0.4	-0.3
Alcohol usually taken with meals	0.1	0.1	0.4	0.6	0.1	0.1
Neuroticism score	0.1	0.2	0.3	-0.6	0.0	-0.6
Happiness	0.1	0.2	0.3	-0.5	-0.4	0.4
Glaucoma (self-reported)	0.1	0.2	0.3	-0.3	-0.6	-0.3
Shortness of breath walking on level ground	0.1	0.1	0.2	-0.1	-0.4	0.5
Eye problems/disorders: None of the above	0.1	0.1	0.2	-0.2	-0.1	-0.4
Leg pain on walking	0.1	0.2	0.4	0.7	0.1	-0.2
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.3	0.2	-0.5	0.2
Illnesses of siblings: Diabetes	0.1	0.1	0.2	0.4	-0.1	-0.4
Mood swings	0.1	0.3	0.4	0.4	0.6	0.5
Average weekly champagne plus white wine intake	0.1	0.1	0.3	-0.5	0.3	0.2
Guilty feelings	0.1	0.2	0.3	-0.6	-0.4	0.4
Financial situation satisfaction	0.1	0.2	0.2	0.5	0.1	0.5
Pain experienced in last month	0.1	0.1	0.2	0.5	-0.4	-0.1
Fed-up feelings	0.0	0.1	0.2	0.1	0.1	-0.4
Past tobacco smoking	0.0	0.0	0.0	-0.1	0.0	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.2	0.2	0.1	0.4
Number of children fathered	0.0	0.1	0.1	0.3	-0.1	0.2
Smoking status: Previous	0.0	0.1	0.2	0.4	0.2	-0.1
Back pain experienced in last month	0.0	0.1	0.1	0.2	-0.3	-0.0
Eye problems/disorders: Glaucoma	0.0	0.0	0.1	0.2	-0.1	-0.3

Hub : Genes

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Models

Trait associations