TWAS hub - FNDC4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue (Female)	0.0539	0.043	9.6e-02	0.007	NA	-0.009	NA	0.000	1.9e-01	NA	7.3e-01	NA	3.3e-01
2	GTEx	Spleen	0.4140	0.107	2.6e-07	0.270	NA	0.192	NA	0.235	1.3e-07	NA	1.2e-05	NA	1.0e-06
3	GTEx	Thyroid	0.2370	0.066	8.9e-09	0.105	NA	0.161	NA	0.148	2.0e-08	NA	2.2e-12	NA	1.9e-11
4	GTEx	Whole Blood	0.5510	0.189	2.8e-03	-0.001	NA	-0.002	NA	-0.002	3.8e-01	NA	6.6e-01	NA	6.7e-01
5	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1260	0.072	1.6e-03	0.060	0.034	0.024	NA	0.046	2.5e-04	4.5e-03	1.5e-02	NA	1.1e-03
6	TCGA	Thyroid Carcinoma	0.2420	0.073	1.9e-15	0.086	0.158	0.172	NA	0.086	1.1e-08	3.2e-15	1.9e-16	NA	1.0e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	5	6
Triglycerides	142.3	233.0	615.0	8.4	-7.0	-17.7	-24.8	-18.7
Gout (self-reported)	33.8	46.4	121.0	3.6	-3.7	-7.9	-11.0	-8.2
High cholesterol (Self-reported)	33.7	59.7	158.8	4.2	-4.4	-8.7	-12.6	-9.3
Alcohol intake frequency.	31.8	73.9	182.2	5.0	-1.6	-10.9	-13.5	-10.7
Fasting Glucose	31.4	37.6	100.0	-4.7	1.1	7.0	10.0	7.3
Medication: Allopurinol	31.3	41.6	102.0	2.3	-3.0	-7.9	-10.1	-8.4
Blood Platelet Count	19.1	220.9	533.6	11.5	-7.1	-17.4	-23.1	-17.5
Medication: Atorvastatin	17.3	21.3	58.4	2.4	-2.8	-5.3	-7.6	-5.3
Cholesterol lowering medication	15.4	22.7	57.3	2.3	-2.1	-5.8	-7.6	-5.9
Trunk predicted mass	15.3	87.2	213.2	-3.1	2.8	12.1	14.6	12.1
Trunk fat-free mass	15.2	87.5	213.2	-3.1	2.7	12.2	14.6	12.1
Medication: Cholesterol lowering	15.2	23.6	61.8	2.1	-3.5	-5.6	-7.9	-5.7
Pulse rate, automated reading	14.6	47.2	123.2	3.0	-3.1	-8.2	-11.1	-8.6
Whole body water mass	14.2	81.2	198.8	-3.0	2.4	11.7	14.1	11.7
Arm predicted mass (right)	14.0	71.8	179.6	-2.5	2.2	11.0	13.4	10.9
Arm fat-free mass (right)	13.9	71.1	179.6	-2.7	2.5	10.8	13.4	10.8
Whole body fat-free mass	13.9	79.4	193.2	-3.3	2.4	11.6	13.9	11.5
Impedance of arm (left)	13.5	62.4	136.9	1.0	-1.0	-11.0	-11.7	-10.7
Arm fat-free mass (left)	13.4	67.9	167.0	-2.3	2.4	10.7	12.9	10.7
Impedance of whole body	13.4	68.3	148.8	1.6	-0.5	-11.5	-12.2	-11.2
Arm predicted mass (left)	13.2	67.1	166.4	-2.2	2.5	10.6	12.9	10.6
Blood White Count	12.8	94.7	262.4	7.5	-6.3	-9.9	-16.2	-10.6
Impedance of arm (right)	12.4	57.6	130.0	1.0	-0.8	-10.5	-11.4	-10.2
Alcohol intake versus 10 years previously	12.1	18.2	46.2	1.6	-1.2	-5.0	-6.8	-5.8
Basal metabolic rate	11.8	65.3	161.3	-2.8	2.1	10.4	12.7	10.5
Type 2 Diabetes (T2D) (2018)	10.6	19.9	61.5	-1.5	2.5	4.9	7.8	5.1
Leg predicted mass (right)	10.6	56.6	136.9	-3.0	1.5	9.8	11.7	9.7
Leg fat-free mass (right)	10.5	56.2	136.9	-2.9	1.5	9.8	11.7	9.7
Leg fat-free mass (left)	10.2	54.2	134.6	-2.9	1.8	9.4	11.6	9.5
Leg predicted mass (left)	10.2	54.0	134.6	-3.0	1.8	9.4	11.6	9.4
Medication: Simvastatin	9.7	14.3	36.4	2.6	-2.1	-4.3	-6.0	-4.5
Diabetes diagnosed by doctor	9.6	15.8	49.2	-1.0	2.8	4.1	7.0	4.4
Medication for cholesterol	9.6	14.6	28.1	-2.9	1.8	4.8	5.3	5.0
Pulse rate	9.4	15.8	40.7	0.8	-1.6	-4.9	-6.4	-5.1
Impedance of leg (right)	9.3	44.9	94.7	1.9	0.8	-9.3	-9.7	-9.2
Impedance of leg (left)	9.2	44.5	97.4	1.9	0.3	-9.2	-9.9	-9.1
Crohns Disease (2017)	7.3	15.9	43.6	0.2	-1.9	-4.7	-6.6	-5.1
Number of self-reported non-cancer illnesses	7.3	12.6	30.4	1.3	-3.0	-4.0	-5.5	-4.3
Diabetes (self-reported)	6.9	10.6	36.7	-1.0	2.9	2.7	6.1	3.2
Medication: Metformin	6.8	9.6	26.5	-1.3	2.7	3.1	5.1	3.5
Diabetes (mother)	6.5	8.3	16.9	-2.1	1.0	3.6	3.9	4.1
Bipolar Disorder (2018)	6.3	10.0	19.4	2.2	-0.6	-4.2	-4.2	-4.4
Cardiovascular Disease	6.3	20.8	50.7	2.3	-4.8	-4.7	-7.1	-4.9
Diabetes (father)	6.3	7.8	18.5	-0.4	1.9	3.3	4.3	3.7
Comparative height size at age 10	6.0	32.8	78.9	-2.9	2.6	7.0	8.9	7.3
Sitting height	5.9	42.0	106.1	-3.6	2.7	7.8	10.3	8.0
Bipolar Disorder (2011)	5.8	5.6	11.4	0.6	-0.9	-3.3	-3.1	-3.4
Weight	5.5	27.1	70.8	-1.8	1.6	6.4	8.4	6.7
Relative age of first facial hair	5.2	10.6	32.8	0.3	1.4	-4.1	-5.7	-3.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	5.1	6.0	10.7	3.1	0.4	-3.0	-3.3	-2.6
Had menopause	5.0	6.2	17.3	-3.5	4.2	-0.3	2.8	-0.3
Number of treatments/medications taken	4.7	8.4	17.8	3.0	-3.2	-2.5	-4.2	-2.6
Medication for cholesterol, blood pressure or diabetes	4.5	7.5	17.8	-1.5	3.0	2.7	4.2	2.9
Illnesses of siblings: Diabetes	4.4	5.4	10.6	-2.6	-1.2	2.8	3.2	2.4
Schizophrenia vs Biploar Disorder	4.3	5.6	15.6	-2.9	1.2	2.0	4.0	2.1
Irritable Bowel Disease (IBD)	4.2	10.1	27.2	1.1	-3.0	-3.2	-5.2	-3.6
Mouth/teeth dental problems: Dentures	4.0	6.8	15.0	1.3	0.9	3.9	3.5	3.3
Illnesses of father: Heart disease	3.8	5.3	11.6	1.9	-1.5	-2.7	-3.4	-2.5
Ever had hysterectomy (womb removed)	3.7	4.1	10.8	0.6	-0.8	-2.7	-2.4	-3.3
LDL Cholesterol	3.6	5.7	15.9	-0.4	0.0	-3.1	-4.0	-3.0
Medication: Paracetamol	3.6	6.0	14.7	3.2	-3.8	-1.3	-2.5	-1.8
High blood pressure (siblings)	3.6	5.2	13.8	2.1	-2.2	-1.9	-3.7	-2.2
Crohns Disease (2012)	3.5	5.6	13.8	0.5	-0.4	-3.0	-3.7	-3.2
Mouth/teeth dental problems: Bleeding gums	3.5	4.5	8.4	1.9	-2.6	-1.8	-2.9	-2.2
Osteoporosis (self-reported)	3.5	4.3	12.2	0.8	-1.1	-2.3	-3.5	-2.5
Bipolar Disorder or Schizophrenia	3.4	8.4	20.4	-0.2	1.6	-4.4	-2.9	-4.5
Blood Red Count	3.4	32.7	67.5	1.1	-3.8	8.2	7.1	7.9
Ulcerative Colitis	3.3	4.8	13.4	1.2	-3.7	-1.3	-2.8	-2.1
Standing height	3.3	32.8	90.8	-3.7	3.0	6.4	9.5	6.5
Medication: Paracetamol	3.3	5.0	8.4	2.6	-2.9	-1.5	-2.6	-2.4
Medication for pain relief, constipation, heartburn	3.2	5.4	13.5	-3.7	3.5	0.6	2.3	0.9
Medication: Gliclazide	3.2	3.6	11.8	-1.2	1.8	1.4	3.4	1.7
Primary Biliary Cirrhosis	3.1	4.5	11.7	-0.3	-2.3	-2.1	-3.4	-2.2
Vitamin and mineral supplements	3.0	4.0	7.7	-2.8	1.6	2.0	2.4	2.1
Height	2.9	56.0	163.8	-5.0	4.8	7.7	12.8	8.1
Number of children fathered	2.9	3.3	8.5	0.4	0.2	2.9	2.2	2.5
Worry too long after embarrassment	2.8	4.6	14.6	0.2	-1.3	2.8	1.9	3.8
Pulse wave reflection index	2.7	3.4	7.4	-0.2	0.5	2.5	2.5	2.7
Number of operations (self-reported)	2.7	4.0	8.1	2.8	-2.9	-0.7	-1.8	-2.0
Hip circumference	2.6	11.2	28.6	0.4	1.1	4.0	5.3	4.6
Ever had bowel cancer screening	2.6	3.1	6.5	-0.0	-0.8	-2.5	-2.3	-2.5
BMI	2.5	14.6	33.8	-0.9	-0.0	4.9	5.8	5.3
Bilateral oophorectomy (both ovaries removed)	2.5	2.9	7.0	2.3	-2.7	-0.6	-1.8	-0.9
Alcohol usually taken with meals	2.5	4.0	7.3	1.3	-1.7	-2.4	-2.7	-2.5
Systolic Blood Pressure	2.3	11.7	28.0	3.0	-5.3	-2.7	-4.3	-2.7
Hand grip strength (left)	2.3	6.0	11.7	-2.6	1.6	2.7	3.4	2.8
Eye problems/disorders: Diabetes related eye disease	2.3	2.5	7.0	-0.2	-0.2	1.9	2.7	2.2
Hand grip strength (right)	2.2	6.0	13.5	-1.6	1.4	3.0	3.7	3.0
Stomach or abdominal pain in last month	2.2	2.8	9.6	3.1	-1.0	-0.5	-2.4	-0.1
Health satisfaction	2.2	2.8	6.6	1.8	-1.4	-1.6	-2.6	-1.6
Ever had stillbirth, spontaneous miscarriage or termination	2.2	2.3	5.5	2.3	-2.0	-0.5	-1.6	-1.2
Average weekly spirits intake	2.1	2.5	6.0	1.8	-0.3	-2.5	-1.7	-1.8
Supplements: Calcium	2.1	2.3	4.9	2.2	-0.4	-1.9	-1.4	-1.8
Allergy or Eczema	2.0	5.2	15.8	0.9	-2.8	-1.5	-4.0	-2.1
Other serious medical condition/disability diagnosed by doctor	2.0	2.6	5.8	0.9	-1.1	-2.1	-2.4	-1.8
Fluid intelligence score	2.0	4.2	10.0	-0.1	1.4	2.7	2.5	3.2
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.2	5.5	0.8	-0.4	-2.2	-1.5	-2.4
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.3	7.8	-1.0	1.1	1.5	2.8	1.1
Medication for hormone replacement therapy	1.9	2.1	5.0	1.5	-0.3	-1.9	-1.3	-2.2
Body mass index (BMI)	1.9	8.1	18.7	0.0	0.2	3.7	4.3	4.1
Number of incorrect matches in round	1.9	3.2	10.6	-0.4	1.1	-3.2	-1.2	-2.5
Falls in the last year	1.9	2.6	4.7	1.6	-0.9	-2.0	-1.8	-2.2
Birth weight of first child	1.9	3.4	12.4	-0.4	3.5	1.0	2.4	1.1
Overall health rating	1.9	4.2	9.6	2.2	-3.1	-0.9	-2.6	-1.7
Medication: Blood pressure	1.9	3.6	7.1	1.1	-1.3	-2.4	-2.7	-2.4
Schizophrenia (2014)	1.8	3.9	8.0	-1.2	2.5	-2.8	-0.8	-2.6
Hayfever, allergic rhinitis or eczema	1.8	3.9	12.8	0.7	-2.7	-1.1	-3.6	-1.4
Arm fat mass (right)	1.8	7.3	19.3	-0.7	0.5	3.2	4.4	3.7
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.2	6.2	2.1	-2.5	-0.5	-1.4	-0.6
Eye problems/disorders: Cataract	1.8	2.1	5.5	2.4	-2.2	0.1	-1.6	-0.1
Arm fat mass (left)	1.8	7.2	19.0	-0.4	0.5	3.2	4.4	3.7
Average weekly champagne plus white wine intake	1.8	2.5	6.8	-1.3	-0.5	1.6	2.6	1.9
Vascular/heart problems diagnosed by doctor	1.8	4.9	12.4	-0.9	3.5	1.9	2.8	2.1
Leg fat mass (left)	1.8	6.9	19.4	-0.9	0.6	3.0	4.4	3.4
Schizophrenia (2018)	1.7	3.4	6.2	-2.1	2.5	-2.2	-0.3	-2.3
Prostate Cancer	1.7	2.4	4.8	0.9	0.2	-2.2	-2.0	-2.1
Coronary Artery Disease (CAD)	1.7	2.0	4.8	-0.4	-0.4	-2.2	-1.8	-1.9
Angina	1.7	2.2	5.0	-0.6	-1.8	-1.4	-2.2	-1.6
Alcohol drinker status: Never	1.7	2.0	3.3	1.5	0.5	-1.8	-1.8	-1.7
Commuting to job workplace: Cycle	1.7	2.1	4.2	1.2	1.3	1.8	1.3	2.1
Age at First Birth	1.6	2.3	5.3	1.1	-0.1	-2.3	-1.6	-2.1
Medication: Co-codamol	1.6	1.8	3.3	1.8	1.6	-1.3	-1.2	-1.4
High blood pressure	1.6	4.5	13.5	1.2	-3.7	-1.8	-2.4	-1.8
Waist circumference	1.6	5.8	16.8	-0.5	1.0	2.9	4.1	3.0
Pain all over the body in last month	1.6	1.8	6.9	0.6	-2.6	-0.7	-0.9	-1.4
Eye problems/disorders: None of the above	1.6	1.9	7.8	-2.8	1.2	-0.9	0.4	-1.1
Depression (Nagel 2018)	1.5	2.3	4.9	2.1	-0.7	-1.6	-2.2	-1.3
HDL Cholesterol	1.5	2.5	5.7	1.1	2.4	1.2	1.9	1.8
Lupus	1.5	2.3	8.8	0.2	-3.0	-0.9	-1.6	-1.3
Relative age voice broke	1.5	2.3	8.7	-0.8	-0.1	-1.3	-3.0	-1.6
Multivitamins +/- minerals	1.5	1.9	4.9	2.2	-1.1	-1.1	-1.7	-1.0
High blood pressure (mother)	1.5	2.1	7.4	2.7	-1.8	0.5	-1.3	0.1
Illnesses of mother	1.5	1.9	6.2	-2.5	1.7	-0.8	0.6	-1.1
Exposure to tobacco smoke outside home	1.5	2.0	4.0	1.9	-0.2	1.9	0.9	2.0
Leg fat mass (right)	1.5	5.8	17.1	-0.8	0.7	2.6	4.1	3.1
Osteoarthritis (self-reported)	1.5	1.9	5.2	1.0	-0.2	-2.1	-0.7	-2.3
Blood Eosinophil Count	1.4	10.9	27.9	2.2	-1.5	5.0	2.3	5.3
Lung FVC	1.4	7.1	15.6	0.7	-0.7	-3.6	-3.7	-4.0
Tanning	1.4	16.8	43.6	-2.8	3.4	4.2	6.6	4.5
Age when periods started (menarche)	1.4	3.4	13.5	0.3	3.7	-1.3	-1.6	-1.5
Illnesses of siblings	1.4	1.9	4.8	-0.7	2.1	0.8	2.2	1.0
Headache pain in last month	1.4	2.4	8.8	1.3	-1.4	-1.0	-3.0	-1.1
Ulcerative Colitis (UC)	1.3	2.5	6.9	1.6	-2.6	-0.7	-2.0	-0.9
Mean Putamen Volume	1.3	1.5	3.1	-0.6	0.8	-1.8	-1.7	-1.5
Neuroticism	1.3	3.2	11.3	3.4	-2.2	0.9	-0.6	1.4
Chronic bronchitis/emphysema (father)	1.3	1.5	3.5	0.5	-0.5	-1.7	-1.9	-1.5
Had other major operations	1.3	1.6	7.5	2.7	-1.3	0.2	0.1	-0.7
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.6	5.7	2.4	-1.8	-0.3	-0.7	-0.4
Length of working week for main job	1.3	1.4	2.4	0.7	1.4	1.2	1.5	1.6
Ever highly irritable/argumentative for 2 days	1.3	1.5	6.7	2.6	-0.7	1.3	-0.3	0.6
Comparative body size at age 10	1.3	3.5	13.0	1.4	-0.9	-1.7	-3.6	-1.6
Angina (self-reported)	1.3	1.7	4.1	-0.7	-1.5	-1.3	-2.0	-1.3
Average weekly red wine intake	1.3	1.9	4.3	-1.8	-0.2	1.5	2.1	1.3
Hearing aid user	1.3	1.5	3.8	-1.2	-1.1	-0.8	-1.9	-1.5
Heart disease (siblings)	1.3	1.7	5.0	0.7	-0.6	-1.4	-2.2	-1.4
Waist Hip Ratio (WHR)	1.2	5.5	14.9	-0.7	-0.5	-2.9	-3.0	-3.9
Smoking Status	1.2	2.9	7.6	-0.6	-0.2	-2.4	-1.9	-2.8
Systolic blood pressure, automated reading	1.2	3.4	11.0	1.7	-3.3	-1.2	-1.9	-1.0
Breastfed as a baby	1.2	1.5	3.9	0.5	1.6	-2.0	-0.1	-1.5
Peak expiratory flow (PEF)	1.2	2.8	7.5	0.3	-1.4	2.7	1.5	2.1
Medication: Ventolin 100micrograms inhaler	1.2	1.6	5.2	-0.7	-2.3	-0.9	-1.5	-0.9
Heart disease (mother)	1.2	1.5	3.4	1.1	-1.9	-1.0	-1.6	-0.9
Hypertension (Self-reported)	1.2	3.4	12.4	0.9	-3.5	-1.2	-2.0	-1.3
Miserableness	1.2	2.2	6.9	2.6	-1.4	-0.3	-2.0	-0.3
Guilty feelings	1.2	1.8	4.5	1.2	-0.6	2.1	0.7	2.0
Mother’s age at death	1.2	1.5	3.5	-1.7	0.7	-1.9	-0.1	-1.5
Ovarian Cancer	1.1	1.4	4.0	0.5	-1.2	2.0	-0.1	1.6
Frequency of depressed mood in last 2 weeks	1.1	1.5	4.7	0.9	-0.9	-1.1	-2.2	-1.2
Hearing difficulty/problems with background noise	1.1	1.7	4.2	-0.1	-2.1	-1.5	-0.7	-1.8
Neuroticism score	1.1	2.2	4.3	2.1	-1.7	1.6	0.1	1.9
Illnesses of father: None of the above (group 1)	1.1	1.4	3.0	-0.5	0.2	1.6	1.6	1.7
Alzheimer’s Disease (in mother)	1.0	1.2	2.3	0.1	-1.3	-1.4	-1.5	-1.0
Ever used hormone-replacement therapy (HRT)	1.0	1.3	6.1	-0.3	2.5	0.1	1.2	-0.1
Townsend deprivation index at recruitment	1.0	1.4	3.3	-1.8	1.8	0.7	1.0	0.7
Taking other prescription medications	1.0	1.5	4.6	-0.4	-2.1	-0.9	-1.6	-1.0
Medication: Ibuprofen	1.0	1.2	5.3	2.3	-0.5	-0.4	-1.0	-0.4
Suffer from ‘nerves’	1.0	1.6	4.3	0.9	0.1	1.9	0.8	2.1
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	6.6	-0.6	1.1	1.8	2.6	1.3
Mouth/teeth dental problems: Mouth ulcers	1.0	1.7	2.8	0.8	-1.6	-1.1	-1.6	-1.7
Deep venous thrombosis (DVT) (self-reported)	1.0	1.2	2.7	0.5	-1.2	1.2	1.6	1.2
Type 2 Diabetes (T2D) (2012)	0.9	1.1	3.1	-1.3	-0.2	0.6	1.8	1.1
Blood clot in the leg (DVT)	0.9	1.2	2.4	0.7	-1.3	1.2	1.6	1.0
Whole body fat mass	0.9	3.8	11.8	-0.7	0.6	1.9	3.4	2.5
Family relationship satisfaction	0.9	1.1	2.6	-0.3	1.6	1.0	1.5	0.7
Leg pain on walking	0.9	1.1	2.7	0.9	-0.6	1.6	1.0	1.3
Commuting to job workplace: Car/motor vehicle	0.9	1.0	2.6	1.3	-0.6	-1.0	-0.7	-1.6
Back pain experienced in last month	0.9	1.3	3.4	0.9	-1.8	1.6	0.4	0.9
Eye problems/disorders: Glaucoma	0.9	1.0	2.3	0.0	1.2	1.4	0.7	1.5
Supplements: Fish oil (including cod liver oil)	0.9	1.1	5.0	2.2	-0.1	-0.7	-1.0	-0.3
Illnesses of father: High blood pressure	0.9	1.1	3.7	0.7	-1.9	-0.5	-1.1	-0.9
Pain experienced in last month	0.9	1.5	4.8	-1.4	2.2	0.0	1.2	0.9
Basal cell carcinoma (self-reported)	0.9	1.0	3.2	0.7	-1.1	1.8	0.8	0.8
Alcohol drinker status: Previous	0.9	1.1	3.3	-0.4	0.8	-1.8	-0.9	-1.2
Verbal and Numeric Reasoning (VNR)	0.8	1.9	4.7	-0.0	1.1	1.4	1.8	2.2
Hearing difficulty/problems: Yes	0.8	1.3	5.3	-0.7	-2.3	-0.2	-1.1	-0.9
Serious illness, injury or assault to yourself	0.8	1.0	2.4	1.1	-1.5	-0.5	-0.8	-1.1
Trunk fat mass	0.8	3.2	10.8	-0.9	0.9	1.6	3.3	2.1
Past tobacco smoking	0.8	1.4	4.5	0.4	0.0	1.7	0.9	2.1
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	2.7	0.3	-1.5	-1.0	-1.6	-1.2
Hair/balding pattern: Pattern 2	0.8	1.0	4.6	2.2	0.5	-0.1	-0.5	0.8
Mouth/teeth dental problems	0.8	1.3	5.7	-2.4	0.7	-1.1	-0.6	-0.4
Allergy	0.8	1.9	6.8	-0.6	2.6	0.5	1.9	0.8
Worrier / anxious feelings	0.8	1.6	5.5	-0.1	-2.4	1.5	-0.0	1.3
Number of live births	0.8	1.1	2.7	0.2	-1.3	-0.7	-1.1	-1.6
Happiness	0.8	0.9	2.2	1.5	-0.4	-0.7	-1.4	-0.9
Number of full brothers	0.8	1.0	3.8	0.8	2.0	-1.0	0.1	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	1.8	-0.8	1.3	-1.3	-0.4	-1.3
Migraine (self-reported)	0.8	1.0	4.0	2.0	-1.3	-0.1	-0.8	0.0
Medication: Aspirin	0.8	1.0	3.3	1.2	0.0	-0.6	-1.8	-1.0
Smoking status: Previous	0.8	1.2	3.7	-0.6	-0.1	-1.8	-0.6	-1.9
Mood swings	0.8	1.4	3.7	1.9	-1.9	0.7	-0.8	0.4
Qualifications: nursing, teaching	0.8	1.3	5.1	0.1	-2.3	-1.1	-0.3	-1.2
Ever taken oral contraceptive pill	0.8	0.9	2.5	-0.9	-1.1	0.8	1.6	0.7
Medication: Lisinopril	0.8	1.0	2.2	0.1	-1.5	0.8	1.1	1.3
Irritability	0.8	1.4	6.5	-0.3	-2.5	0.7	0.2	1.1
Ever had prostate specific antigen (PSA) test	0.8	1.0	4.4	-0.0	-2.1	0.5	1.0	0.4
Unable to work because of sickness or disability	0.8	1.0	5.8	-0.0	2.4	-0.2	0.5	-0.4
Myopia	0.8	1.1	2.3	1.0	1.0	-1.5	-1.2	-1.1
Major Depression (MDD)	0.7	0.8	1.9	-0.2	1.2	-1.4	-0.1	-1.2
Body Mass Index (BMI) (2010)	0.7	1.0	3.0	-0.3	1.7	0.4	1.4	0.9
HbA1C	0.7	0.8	2.1	0.7	0.4	0.9	1.1	1.5
Chronotype (morning person)	0.7	1.5	3.6	1.6	0.5	1.9	0.3	1.6
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	2.4	1.1	-1.6	0.0	-1.1	-0.4
Qualifications: A levels/AS levels or equivalent	0.7	1.5	5.5	-2.3	-1.5	0.9	0.1	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	2.3	1.5	-0.0	-1.4	-0.8	-1.3
Glaucoma (self-reported)	0.7	0.8	1.6	0.4	1.3	1.2	0.4	1.1
Had major operations	0.7	0.9	1.7	1.3	-1.2	-0.5	-0.8	-1.0
Mineral and other dietary supplements	0.7	0.9	2.9	-1.7	-0.6	0.9	1.0	0.5
Medication: Bendroflumethiazide	0.7	1.0	3.7	1.9	-0.4	-0.5	-1.2	-0.7
Ever smoked	0.7	1.3	4.2	0.0	0.5	-1.5	-1.1	-2.0
Average weekly beer plus cider intake	0.7	1.0	3.0	-1.7	1.0	0.9	0.6	0.8
Depressed Affect (Nagel 2018)	0.6	1.3	5.2	2.3	-1.0	-0.0	-1.1	0.1
Neuroticism (Nagel 2018)	0.6	1.5	3.3	1.1	-0.9	1.8	0.9	1.8
Breast Cancer	0.6	1.4	3.5	1.1	1.2	-1.0	-1.9	-1.1
Neuroticism (2016)	0.6	0.9	5.0	2.2	0.4	0.5	-0.0	0.3
Maternal smoking around birth	0.6	0.8	2.1	-1.5	0.2	-1.1	-0.5	-1.1
Fed-up feelings	0.6	1.1	2.6	1.1	-0.6	1.5	0.0	1.6
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.3	1.1	0.6	-1.1	-1.1	-0.0
Medication: Ramipril	0.6	0.7	1.7	-0.1	-0.8	-1.0	-1.0	-1.3
Time employed in main current job	0.6	0.7	2.5	-1.6	-0.8	-0.8	-0.1	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	3.1	1.3	-1.8	0.3	-0.7	0.3
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	1.9	-0.7	-1.3	1.2	0.4	1.4
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.3	0.6	0.1	-0.9	-1.5	-0.9
Medication: Blood pressure	0.6	1.0	5.1	0.6	-2.3	0.6	-0.0	0.4
Age at last live birth	0.6	0.8	2.9	0.1	-0.0	-1.1	-0.9	-1.7
Intelligence (Savage-Jansen 2018)	0.5	1.6	5.1	0.3	0.5	1.8	1.1	2.3
Hair Pigment	0.5	13.8	35.9	4.7	-6.0	1.2	-4.8	-0.8
Sensitivity / hurt feelings	0.5	0.8	1.9	1.4	-1.1	0.7	0.6	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	4.1	-0.9	1.4	0.5	2.0	0.4
Medication: Atenolol	0.5	0.6	1.9	-0.1	-0.2	1.4	0.4	1.2
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	5.0	-0.1	0.3	2.2	1.5	1.8
Exposure to tobacco smoke at home	0.5	0.6	1.5	-0.5	-0.5	-1.1	-0.7	-1.2
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.1	1.0	-0.7	1.1	0.5	0.9
Emphysema/chronic bronchitis	0.5	0.6	2.0	0.1	0.2	0.6	1.4	1.0
Medication: Omeprazole	0.5	0.6	1.8	0.4	-0.9	1.3	0.3	1.0
Chest pain or discomfort	0.5	0.7	2.1	1.5	-0.3	-0.2	-1.5	-0.1
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	2.5	-1.6	-0.2	0.1	1.0	0.4
Loneliness, isolation	0.5	0.6	2.5	1.6	-0.4	-0.0	-1.1	-0.3
Friendships satisfaction	0.5	0.6	2.0	1.4	0.0	-0.6	-0.8	-0.9
Medication: Aspirin	0.5	0.7	2.2	1.1	-0.1	-0.4	-1.5	-0.8
Smoking status: Current	0.5	0.7	2.4	-0.4	0.3	-0.8	-1.6	-1.1
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.9	0.6	-1.7	-0.2	-0.4	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	2.0	0.6	-1.4	0.8	-0.5	0.3
Worry (Nagel 2018)	0.4	0.8	2.2	0.6	-1.0	1.5	0.4	1.2
Alzheimer’s Disease (including proxy)	0.4	0.6	1.2	-0.1	-0.9	-1.1	-0.8	-0.9
Reaction Time	0.4	0.7	3.1	-1.8	-0.8	-0.4	-0.6	-0.4
Severe depression (siblings)	0.4	0.4	1.2	0.3	1.1	-0.0	0.9	0.6
Trunk fat percentage	0.4	1.6	5.1	0.2	0.2	-2.3	-1.3	-1.7
Current tobacco smoking	0.4	0.6	2.5	-0.1	0.3	-0.7	-1.6	-0.8
Average weekly fortified wine intake	0.4	0.5	1.6	0.4	0.0	0.3	1.2	0.9
Supplements: Glucosamine	0.4	0.6	3.0	0.2	1.7	0.6	0.1	-0.0
Nervous feelings	0.4	0.8	2.4	0.1	-0.6	1.6	0.8	1.2
Financial difficulties in last 2 years	0.4	0.5	0.9	0.5	0.2	-0.8	-0.9	-1.0
Heart attack	0.4	0.4	1.3	-0.3	-1.1	0.0	-0.8	-0.8
Father’s age at death	0.4	0.5	2.1	-1.0	-1.5	-0.3	0.2	-0.2
Hair/balding pattern: Pattern 3	0.4	0.6	2.0	-0.3	1.4	0.0	1.3	0.1
Asthma	0.4	0.7	1.9	-0.8	-0.6	-1.4	-0.4	-1.1
Depression (self-reported)	0.4	0.5	1.3	0.2	0.4	-0.9	-0.7	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	3.6	-0.2	0.4	1.9	1.4	1.6
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.3	-0.2	0.2	-1.3	-1.0	-1.5
Forced vital capacity (FVC), Best measure	0.4	1.5	3.8	-0.6	0.8	1.5	2.0	1.5
Pulse wave peak to peak time	0.4	0.4	1.2	-0.7	0.9	0.1	1.1	0.4
Neck or shoulder pain in last month	0.4	0.6	2.9	0.5	-1.7	0.6	0.3	-0.3
Mean time to correctly identify matches	0.4	0.8	2.5	-1.6	-0.9	-0.7	-0.3	-0.7
Number of full sisters	0.4	0.4	2.2	-1.5	-0.4	0.4	-0.1	-0.2
Supplements: Vitamin C	0.4	0.5	1.3	1.2	-1.0	-0.3	0.0	-0.6
Asthma (self-reported)	0.4	0.8	2.4	-0.4	-0.5	-1.6	-0.7	-1.2
Financial situation satisfaction	0.4	0.5	2.5	1.6	0.1	0.4	0.0	0.3
Risk taking	0.4	0.6	1.6	-0.1	1.3	-1.0	0.0	-0.9
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.1	-0.4	-1.0	-0.2	-0.9	-1.0
Rheumatoid Arthritis	0.3	0.4	0.8	-0.7	0.6	0.3	0.7	0.9
Pack years adult smoking proportion	0.3	0.5	2.6	1.6	-0.0	0.3	-0.3	0.2
Qualifications: CSEs or equivalent	0.3	0.4	1.2	1.1	0.5	-0.3	-0.6	-0.6
Forced vital capacity (FVC)	0.3	1.3	3.0	-0.7	1.0	1.4	1.7	1.2
Qualifications: None of the above	0.3	0.7	2.1	-0.0	1.4	-1.1	-0.4	-0.9
Noisy workplace	0.3	0.4	0.8	-0.3	0.6	-0.9	-0.7	-0.7
Tense / ‘highly strung’	0.3	0.5	1.7	0.4	-0.6	-0.6	-1.3	-0.7
Loud music exposure frequency	0.3	0.3	0.9	-0.4	-0.1	0.6	0.8	1.0
Medication: Amlodipine	0.3	0.4	0.7	0.9	-0.9	-0.3	0.5	-0.7
Birth weight	0.3	0.6	1.0	0.9	-0.7	0.4	1.0	1.0
Body fat percentage	0.3	1.1	3.5	0.4	-0.1	-1.9	-1.2	-1.3
Wheeze or whistling in the chest in last year	0.3	0.5	1.8	0.1	-1.3	0.7	-0.1	0.7
Medication: Seretide 50 evohaler	0.3	0.3	1.0	-1.0	0.4	-0.1	0.8	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.3	-0.6	-1.1	0.7	-0.5	0.1
Knee pain experienced in last month	0.3	0.5	1.3	1.1	-0.4	-0.6	-0.4	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.7	0.8	-0.8	-0.1	-0.8	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	2.1	-0.3	-0.8	-0.6	-1.1	-1.5
Wears glasses or contact lenses	0.3	0.4	1.0	-0.3	-0.4	-0.8	-0.4	-1.0
Commuting to job workplace: Public transport	0.3	0.4	1.1	-0.4	0.3	0.9	0.3	1.0
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.7	0.3	-0.2	0.5	1.3	0.5
Fractured/broken bones in last 5 years	0.3	0.3	0.7	0.7	-0.8	0.8	-0.1	0.5
Age started oral contraceptive pill	0.3	0.4	1.0	-1.0	0.8	-0.7	-0.6	-0.2
Diastolic blood pressure, automated reading	0.3	1.0	4.5	1.0	-2.1	0.5	0.5	0.3
Ever depressed for a whole week	0.3	0.4	0.9	0.9	0.4	-0.9	-0.4	-0.5
Heel T-Score	0.2	1.8	5.1	-1.6	1.5	0.8	2.2	0.8
Respiratory disease	0.2	0.5	0.9	-0.4	-0.5	-1.0	-0.9	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.4	1.2	-0.1	-0.1	-0.6	-0.1
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	1.4	-1.2	-0.0	0.1	0.3	0.0
Medication: Levothyroxine sodium	0.2	0.3	1.1	0.3	-1.1	-0.1	-0.6	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	2.0	-0.7	0.3	-0.2	1.4	-0.3
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.0	-1.0	-0.1	0.2	-0.8	0.1
Medication: Lansoprazole	0.2	0.2	0.6	0.8	-0.4	0.0	-0.6	-0.6
Prospective memory result	0.2	0.3	1.0	-0.4	0.4	-0.7	-0.3	-1.0
Lung cancer (father)	0.2	0.2	0.8	-0.9	-0.2	-0.4	-0.6	0.0
Pulse wave Arterial Stiffness index	0.2	0.2	0.6	0.6	-0.8	0.5	-0.3	0.2
Hair/balding pattern: Pattern 4	0.2	0.6	1.7	-1.3	0.2	0.2	1.3	-0.1
Shortness of breath walking on level ground	0.2	0.3	1.4	0.1	1.2	-0.2	-0.2	-0.1
Qualifications: College or University degree	0.2	0.6	1.0	-1.0	-0.8	-0.6	-0.9	-1.0
Pack years of smoking	0.2	0.3	1.6	1.3	0.3	0.3	0.0	0.2
Alzheimer’s Disease (in father)	0.1	0.1	0.4	-0.3	-0.5	-0.0	0.7	-0.1
Hypothyroidism (self reported)	0.1	0.3	1.4	-0.7	-1.2	0.2	-0.3	-0.3
Lung FEV1/FVC ratio	0.1	0.5	2.7	-0.1	0.3	1.6	-0.6	0.3
Supplements: Zinc	0.1	0.1	0.3	0.0	-0.3	-0.5	0.4	-0.3
Leg fat percentage (right)	0.1	0.5	1.4	0.7	0.4	-1.2	-0.6	-0.6
Age at first live birth	0.1	0.2	0.4	0.1	-0.6	-0.1	-0.6	-0.5
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.6	-0.5	0.1	0.0	0.0	-0.7
Long-standing illness, disability or infirmity	0.1	0.2	1.0	1.0	0.0	0.5	0.0	0.3
Commuting to job workplace: Walk	0.1	0.1	0.2	0.1	0.4	-0.3	-0.4	-0.1
Breast cancer (self-reported)	0.1	0.2	0.4	0.2	-0.5	0.6	0.4	0.1
Arm fat percentage (right)	0.0	0.1	0.4	0.3	-0.2	-0.1	0.3	0.6
Arm fat percentage (left)	0.0	0.1	0.1	0.2	-0.3	-0.4	0.2	0.4
Leg fat percentage (left)	0.0	0.2	0.5	0.6	0.1	-0.7	-0.2	-0.3

Hub : Genes

FNDC4

Models

Trait associations