Best TWAS P=9.36e-11 · Best GWAS P=1.82e-11 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | CD40 | 0.25 | 0.11 | lasso | 6 | 0.15 | 3.5e-11 | -4.8 | -5.8 | 7.7e-09 | -0.48 | 0.39 | 0.59 | FALSE |
| 2 | GTEx | Nerve Tibial | CD40 | 0.13 | 0.01 | lasso | 5 | 0.02 | 1.4e-02 | 5.7 | -6.0 | 1.8e-09 | -0.80 | 0.02 | 0.93 | FALSE |
| 3 | GTEx | Skin Sun Exposed Lower leg | CD40 | 0.13 | 0.08 | lasso | 3 | 0.08 | 4.1e-07 | -5.0 | -5.7 | 1.5e-08 | -0.40 | 0.79 | 0.16 | FALSE |
| 4 | METSIM | Adipose | CD40 | 0.07 | 0.04 | lasso | 4 | 0.05 | 3.5e-08 | 5.9 | -5.9 | 4.3e-09 | -0.75 | 0.04 | 0.96 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | SLC12A5 | 0.24 | 0.24 | lasso | 6 | 0.24 | 5.4e-30 | 6.7 | 6.3 | 3.2e-10 | 0.98 | 0.00 | 1.00 | TRUE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CD40 | 0.06 | 0.05 | blup | 63 | 0.06 | 3.3e-12 | 5.8 | -6.2 | 5.8e-10 | -0.76 | 0.24 | 0.76 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CD40 | 0.04 | 0.02 | enet | 10 | 0.04 | 2.2e-05 | -5.3 | -6.3 | 2.8e-10 | -0.57 | 0.28 | 0.53 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | CD40 | 0.10 | 0.01 | blup | 63 | 0.09 | 5.8e-06 | -5.0 | -6.5 | 9.4e-11 | -0.58 | 0.25 | 0.19 | TRUE |
| 9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CD40 | 0.08 | 0.06 | blup | 63 | 0.09 | 4.4e-10 | 5.6 | -6.3 | 3.0e-10 | -0.75 | 0.01 | 0.99 | FALSE |
| 10 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CD40 | 0.06 | 0.01 | blup | 63 | 0.04 | 6.7e-04 | 6.0 | -5.6 | 1.7e-08 | -0.61 | 0.05 | 0.51 | FALSE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | CD40 | 0.03 | 0.00 | blup | 63 | 0.01 | 1.4e-02 | -5.0 | -6.4 | 1.3e-10 | -0.67 | 0.04 | 0.26 | FALSE |