TWAS hub - SLC12A5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.2440	0.0403	0.0e+00	0.241	0.155	0.229	0.219	0.236	1.3e-30	2.2e-19	6.1e-29	1e-27	5.4e-30
2	TCGA	Breast Invasive Carcinoma	0.0652	0.0288	8.8e-05	0.029	0.026	0.018	NA	0.027	1.1e-06	3.2e-06	1.1e-04	NA	2.0e-06
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0907	0.0301	2.6e-06	0.055	0.058	0.057	NA	0.053	7.6e-07	4.1e-07	4.8e-07	NA	1.4e-06
4	TCGA	Lung Adenocarcinoma	0.0857	0.0441	4.2e-03	0.043	0.021	0.024	NA	0.034	7.3e-06	1.5e-03	7.6e-04	NA	6.3e-05
5	TCGA	Pancreatic Adenocarcinoma	0.1660	0.0750	2.6e-03	0.050	0.060	0.062	NA	0.064	3.9e-03	1.6e-03	1.4e-03	NA	1.1e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Depressed Affect (Nagel 2018)	8.0	16.9	39.5	6.3	2.9	3.7	3.0	3.8
Neuroticism (Nagel 2018)	8.0	18.9	41.6	6.5	2.9	4.2	3.0	4.3
Triglycerides	7.7	12.6	23.5	-1.2	4.8	3.3	4.8	2.2
Crohns Disease (2017)	7.5	16.4	24.8	5.0	-4.8	-2.9	-4.8	-1.6
HDL Cholesterol	7.3	12.2	22.7	0.5	-4.8	-3.0	-4.6	-2.9
Neuroticism	6.7	16.2	35.7	6.0	2.6	4.0	2.7	3.9
Neuroticism (2016)	6.6	9.5	16.3	2.1	2.7	4.0	2.7	3.5
Mean time to correctly identify matches	6.5	12.5	21.1	-1.0	-4.6	-3.8	-4.6	-2.3
Qualifications: nursing, teaching	6.1	9.4	15.4	-0.4	-3.9	-2.9	-3.9	-2.8
Neuroticism score	5.9	12.3	22.1	4.7	2.6	3.4	2.6	3.8
Reaction Time	5.8	11.1	20.4	-1.3	-4.5	-3.3	-4.4	-1.7
Mood swings	5.6	10.1	16.9	4.1	2.4	2.8	2.5	3.7
Sensitivity / hurt feelings	5.4	9.3	13.4	3.7	3.0	2.8	3.1	2.6
Smoking status: Previous	5.3	7.9	13.9	0.8	3.7	2.8	3.7	1.9
Loneliness, isolation	5.2	7.1	9.9	2.9	2.0	3.0	2.0	3.1
Seen doctor (GP) for nerves, anxiety, tension or depression	4.8	7.4	23.2	4.8	1.3	2.6	1.4	1.9
Worrier / anxious feelings	4.2	7.9	15.0	3.2	1.9	3.9	1.9	2.7
Worry (Nagel 2018)	3.9	8.1	16.9	4.1	1.7	3.9	1.8	1.7
Rheumatoid Arthritis	3.8	5.2	21.5	-4.6	1.1	1.4	1.1	0.5
Depression (Nagel 2018)	3.7	5.6	17.3	4.2	1.5	1.2	1.5	2.2
Irritable Bowel Disease (IBD)	3.6	8.6	20.9	4.6	-3.1	-1.2	-3.2	-0.8
Guilty feelings	3.4	5.0	8.0	2.8	2.2	1.1	2.2	2.5
Fed-up feelings	3.3	6.0	19.1	4.4	1.7	1.4	1.7	1.9
Nervous feelings	3.3	6.1	10.8	2.2	2.3	3.3	2.3	2.1
Qualifications: A levels/AS levels or equivalent	3.3	7.3	12.4	-0.6	-3.5	-3.0	-3.5	-1.6
Forced vital capacity (FVC)	3.2	12.5	20.9	2.0	-4.6	-3.5	-4.6	-2.2
Ever highly irritable/argumentative for 2 days	3.2	3.8	6.4	0.7	2.0	2.5	2.1	1.9
Ever had prostate specific antigen (PSA) test	3.1	3.6	4.7	1.0	2.1	1.9	2.2	2.0
Major Depression (MDD)	3.0	3.7	6.6	2.6	1.8	1.2	1.8	1.9
Medication: Ramipril	3.0	3.9	8.0	0.0	-2.3	-1.2	-2.2	-2.8
Depression (self-reported)	3.0	3.6	7.1	2.7	1.4	2.3	1.4	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	3.0	3.9	14.3	3.8	0.9	1.5	0.9	1.1
Medication: Cholesterol lowering	2.9	4.4	9.4	-0.9	2.0	2.1	1.9	3.1
Leg pain on walking	2.9	3.6	4.8	1.9	2.2	1.7	2.2	1.5
Serious illness, injury or assault to yourself	2.8	3.4	6.8	0.8	-1.9	-1.5	-1.9	-2.6
Chronotype (morning person)	2.7	6.2	11.7	-3.4	2.6	2.0	2.6	1.1
Past tobacco smoking	2.7	5.0	8.7	-1.5	-2.9	-2.0	-2.9	-1.3
Forced vital capacity (FVC), Best measure	2.7	10.0	15.8	1.5	-4.0	-3.7	-4.0	-1.6
Bipolar Disorder (2011)	2.6	2.6	9.7	3.1	-0.8	-0.5	-0.8	1.2
Crohns Disease (2012)	2.6	4.2	6.2	2.3	-2.5	-1.8	-2.5	-0.3
Lupus	2.6	3.9	6.0	2.3	-2.1	-0.4	-2.0	-2.4
Prospective memory result	2.6	3.2	6.3	2.5	1.3	2.4	1.4	0.3
Loud music exposure frequency	2.6	2.9	5.4	0.1	-2.3	0.0	-2.2	-2.0
Number of self-reported non-cancer illnesses	2.6	4.5	7.7	1.1	2.4	2.8	2.4	1.4
Miserableness	2.5	4.4	15.9	4.0	0.7	-0.1	0.8	2.3
Blood Red Count	2.4	23.6	33.1	-2.3	-5.4	-4.7	-5.3	-5.8
Lung FVC	2.3	11.6	16.5	2.0	-4.0	-3.7	-4.1	-2.7
High cholesterol (Self-reported)	2.3	4.0	6.1	-2.4	2.5	1.4	2.4	0.8
Age when periods started (menarche)	2.2	5.2	6.5	-1.9	-2.5	-2.5	-2.5	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	2.2	7.0	10.6	1.1	-3.1	-3.3	-3.1	-2.0
Qualifications: College or University degree	2.2	7.0	10.6	-2.1	-3.2	-2.6	-3.3	-1.8
Neck or shoulder pain in last month	2.2	3.1	8.3	2.9	1.3	0.4	1.3	1.9
Ever depressed for a whole week	2.2	2.7	4.1	1.6	2.0	0.9	2.0	1.4
Smoking Status	2.1	5.0	12.8	3.6	1.7	1.3	1.7	2.2
Frequency of depressed mood in last 2 weeks	2.1	2.9	10.4	3.2	0.4	0.3	0.3	2.0
Financial difficulties in last 2 years	2.1	2.8	10.3	1.2	1.0	0.9	0.9	3.2
Chronic bronchitis/emphysema (mother)	2.1	2.5	4.0	-1.2	-1.9	-1.3	-2.0	-1.2
Friendships satisfaction	2.1	2.6	5.8	-0.5	2.4	1.0	2.4	0.7
Breast cancer (self-reported)	2.1	2.5	4.5	0.6	2.1	1.3	2.0	1.4
Pain type(s) experienced in last month: Hip pain	2.1	2.6	4.6	-0.7	2.1	1.5	2.2	1.1
Bipolar Disorder (2018)	2.0	3.2	13.8	3.7	0.5	0.3	0.5	1.2
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.2	6.0	2.1	1.7	0.4	1.6	2.4
Myopia	2.0	2.9	6.5	-1.7	-1.1	-2.5	-1.0	-1.7
Basal cell carcinoma (self-reported)	2.0	2.3	5.3	-0.0	2.3	1.0	2.3	0.1
Bipolar Disorder or Schizophrenia	1.9	4.6	20.5	4.5	0.5	0.2	0.5	1.4
Forced expiratory volume in 1-second (FEV1)	1.9	6.5	9.7	1.4	-3.1	-2.4	-3.1	-2.3
Commuting to job workplace: Cycle	1.9	2.3	4.8	0.8	-2.2	-0.9	-2.2	-0.5
Allergy or Eczema	1.8	4.8	20.8	-4.6	-0.2	-1.8	-0.2	-0.2
Qualifications: None of the above	1.8	3.9	6.1	2.5	2.0	1.9	2.0	1.5
Fluid intelligence score	1.8	3.7	7.8	-1.4	-2.1	-2.8	-2.1	-0.2
Hair/balding pattern: Pattern 3	1.8	2.7	4.4	0.6	2.1	1.5	2.1	1.5
Commuting to job workplace: Public transport	1.8	2.1	4.5	0.7	-2.1	-1.0	-2.1	-0.5
Commuting to job workplace: Car/motor vehicle	1.7	1.9	3.5	-1.5	1.8	0.9	1.9	0.0
Age at First Birth	1.6	2.3	3.7	-1.6	1.9	-0.3	1.9	1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.9	3.5	1.9	0.9	1.3	0.9	1.6
Back pain experienced in last month	1.6	2.3	9.8	3.1	0.3	0.3	0.4	-1.1
Heel T-Score	1.5	11.9	23.0	-0.6	4.8	3.6	4.8	0.7
Average weekly spirits intake	1.5	1.8	6.9	2.6	0.7	-0.1	0.8	1.1
Medication: Co-codamol	1.5	1.7	7.2	2.7	-0.4	0.6	-0.3	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	2.7	1.4	1.6	1.2	1.6	1.1
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.4	5.7	2.0	0.8	1.1	0.7	2.4
Father’s age at death	1.5	2.1	2.9	-1.7	1.6	1.5	1.6	-0.1
Average weekly champagne plus white wine intake	1.5	2.0	2.9	-0.3	-1.5	-1.7	-1.5	-1.6
Intelligence (Savage-Jansen 2018)	1.4	4.4	13.6	-3.7	-1.2	-2.2	-1.3	0.6
Gout (self-reported)	1.4	1.9	2.8	0.1	-1.7	-1.4	-1.7	-1.4
Worry too long after embarrassment	1.4	2.4	6.2	0.1	1.5	1.0	1.5	2.5
Forced expiratory volume in 1-second (FEV1), predicted	1.4	3.0	5.5	-0.8	-2.3	-1.3	-2.3	-1.4
Unable to work because of sickness or disability	1.4	1.8	6.0	2.5	-1.1	-0.2	-1.1	0.8
Heart disease (siblings)	1.4	1.7	4.2	0.4	1.3	0.9	1.3	2.1
Time employed in main current job	1.3	1.5	2.9	1.5	-0.9	-1.7	-0.9	-1.0
Family relationship satisfaction	1.3	1.7	3.1	0.9	1.8	1.0	1.7	0.7
Pain experienced in last month	1.3	2.2	5.5	-2.3	-1.2	-1.6	-1.3	0.1
Alzheimer’s Disease (in mother)	1.2	1.4	3.3	1.8	0.6	1.2	0.5	1.2
Townsend deprivation index at recruitment	1.2	1.7	6.9	0.0	0.8	0.5	0.7	2.6
Mouth/teeth dental problems	1.2	1.9	3.1	-1.3	-1.5	-0.5	-1.5	-1.8
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	3.6	-0.1	-1.5	-1.6	-1.4	-1.9
Exposure to tobacco smoke outside home	1.2	1.6	3.9	2.0	-1.3	-0.5	-1.4	-0.6
Pulse wave peak to peak time	1.2	1.5	5.0	-0.8	0.0	-1.3	0.0	-2.2
Overall health rating	1.2	2.5	4.2	2.0	1.5	1.4	1.4	1.6
Alcohol drinker status: Never	1.2	1.4	6.3	2.5	-0.1	0.7	-0.1	-0.7
Irritability	1.2	2.0	6.1	2.0	0.1	0.2	0.2	2.5
HbA1C	1.1	1.2	2.3	0.1	-1.5	-1.0	-1.5	-0.8
Respiratory disease	1.1	2.4	5.6	-0.5	-2.4	-0.7	-2.4	-0.2
Diabetes (mother)	1.1	1.4	2.5	-1.6	-1.0	-1.0	-1.1	-1.2
Maternal smoking around birth	1.1	1.6	6.1	2.5	0.7	0.3	0.6	0.8
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	6.4	-2.5	-0.2	-0.8	-0.1	0.6
Medication: Simvastatin	1.1	1.6	3.5	0.4	0.7	1.9	0.5	1.9
Pulse wave Arterial Stiffness index	1.1	1.3	4.1	1.1	-0.2	1.0	-0.2	2.0
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	5.1	-2.2	-0.9	-1.4	-1.0	-0.6
Medication: Amlodipine	1.1	1.5	5.7	2.4	-0.4	1.3	-0.4	0.2
Long-standing illness, disability or infirmity	1.1	1.7	5.8	2.4	0.5	1.5	0.5	0.4
Illnesses of father: None of the above (group 1)	1.1	1.4	3.2	-1.8	0.6	-1.3	0.6	-1.1
Medication: Paracetamol	1.1	1.7	6.7	2.6	-1.0	0.2	-0.9	-0.0
Ever smoked	1.1	1.9	3.4	1.3	1.8	1.0	1.8	0.4
Supplements: Calcium	1.1	1.2	3.1	-1.8	-0.6	-0.7	-0.5	-1.3
Type 2 Diabetes (T2D) (2018)	1.0	1.8	3.9	0.0	-2.0	-1.1	-1.9	-0.3
Diabetes (self-reported)	1.0	1.5	2.5	0.7	-1.6	-1.2	-1.6	-0.8
Breastfed as a baby	1.0	1.3	2.4	-0.7	-1.0	-1.1	-1.1	-1.5
Emphysema/chronic bronchitis	1.0	1.1	2.3	1.5	1.0	1.2	0.9	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	3.1	0.6	0.8	1.8	0.8	-1.2
Suffer from ‘nerves’	1.0	1.6	7.3	2.7	0.3	0.8	0.3	0.0
Illness, injury, bereavement, stress in last 2 years	1.0	1.3	2.7	-0.4	1.6	0.9	1.7	0.0
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	4.4	2.1	0.3	0.4	0.3	0.8
Wears glasses or contact lenses	1.0	1.1	2.2	1.5	1.0	1.2	1.0	0.3
Medication: Lisinopril	1.0	1.3	5.6	0.8	0.0	-0.1	-0.0	2.4
Risk taking	1.0	1.4	3.4	1.6	-0.7	-0.1	-0.7	1.9
Verbal and Numeric Reasoning (VNR)	0.9	2.2	3.8	-1.9	-1.4	-1.7	-1.5	0.5
Schizophrenia (2014)	0.9	1.9	8.8	3.0	0.1	-0.7	0.1	-0.0
Relative age of first facial hair	0.9	1.9	3.7	0.8	-1.9	-1.2	-1.9	-0.0
Ever used hormone-replacement therapy (HRT)	0.9	1.1	3.9	2.0	0.1	-0.1	0.1	-1.3
Severe depression (siblings)	0.9	1.0	2.0	1.4	0.8	-0.1	0.8	1.3
Multivitamins +/- minerals	0.9	1.2	1.9	-0.4	1.2	-0.8	1.3	-1.4
Falls in the last year	0.9	1.2	3.5	1.9	-0.9	-0.8	-0.9	-0.3
Number of live births	0.9	1.3	3.3	0.5	0.8	1.4	0.7	1.8
Pulse rate	0.9	1.5	3.2	-1.8	0.7	-0.9	0.7	1.5
Mouth/teeth dental problems: Dentures	0.9	1.5	2.2	0.4	1.4	1.5	1.4	1.2
Medication: Lansoprazole	0.9	1.0	2.9	0.0	0.8	1.7	0.9	0.7
Medication: Paracetamol	0.9	1.5	6.5	2.6	-0.4	0.5	-0.4	0.7
Heart disease (mother)	0.9	1.0	2.5	1.6	-0.3	0.6	-0.3	1.5
Illnesses of father: Heart disease	0.9	1.2	2.6	1.0	0.6	1.4	0.5	1.6
Average weekly red wine intake	0.9	1.3	2.2	1.5	1.2	0.3	1.2	1.2
Diabetes diagnosed by doctor	0.9	1.5	2.7	-0.1	-1.6	-1.3	-1.6	-0.9
Smoking status: Current	0.9	1.4	6.4	2.5	-0.1	-0.5	-0.0	0.4
Mother’s age at death	0.9	1.1	4.2	-0.6	-0.3	-0.8	-0.2	-2.1
Alcohol drinker status: Previous	0.9	1.0	1.8	0.0	0.9	1.3	1.0	1.3
Schizophrenia (2018)	0.8	1.7	8.0	2.8	0.2	-0.0	0.3	0.8
Alzheimer’s Disease (including proxy)	0.8	1.2	2.9	1.7	0.7	1.0	0.5	1.1
Coronary Artery Disease (CAD)	0.8	1.0	1.6	0.6	-1.3	-1.1	-1.3	-0.4
Cardiovascular Disease	0.8	2.7	5.3	-0.4	2.3	1.6	2.2	0.6
Number of treatments/medications taken	0.8	1.5	4.6	2.1	0.2	1.5	0.2	-0.8
Systolic blood pressure, automated reading	0.8	2.2	4.2	-1.7	1.2	-0.9	1.3	-2.1
Medication for hormone replacement therapy	0.8	0.9	2.2	1.5	0.3	1.4	0.3	0.1
Stomach or abdominal pain in last month	0.8	0.9	2.7	1.7	-0.5	0.1	-0.6	1.2
Sitting height	0.8	5.7	11.0	1.3	-2.5	-3.3	-2.5	-1.9
Hair/balding pattern: Pattern 2	0.8	1.0	1.3	-0.8	-1.1	-1.2	-1.1	-0.8
Asthma	0.8	1.6	2.7	-1.7	-1.5	-0.8	-1.5	0.2
Lung cancer (father)	0.8	0.9	2.5	-0.1	1.1	1.6	1.0	0.3
Birth weight of first child	0.8	1.4	2.6	0.9	-1.4	-1.6	-1.4	0.3
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	2.3	1.5	-0.7	-1.0	-0.7	-1.1
Number of full brothers	0.8	1.0	2.0	-0.4	0.9	1.0	0.9	1.4
Number of children fathered	0.8	0.9	1.5	0.5	1.2	1.1	1.1	0.2
Medication for pain relief, constipation, heartburn	0.8	1.4	4.0	-2.0	-0.7	-0.9	-0.7	-1.1
Chest pain or discomfort	0.8	1.2	4.7	1.0	0.4	0.3	0.4	2.2
Had major operations	0.8	0.9	2.4	1.6	-0.5	0.8	-0.5	-1.0
Knee pain experienced in last month	0.8	1.3	5.5	2.4	0.4	0.7	0.4	-0.1
Osteoarthritis (self-reported)	0.8	1.1	1.8	-0.2	1.2	1.3	1.3	-0.6
Ever taken oral contraceptive pill	0.8	0.9	3.1	1.8	0.3	-0.4	0.4	1.0
Hearing aid user	0.8	0.9	2.3	1.3	-0.3	0.7	-0.3	1.5
Number of operations (self-reported)	0.8	1.1	2.4	1.6	1.2	0.3	1.1	-0.6
Primary Biliary Cirrhosis	0.7	1.0	4.0	2.0	-0.7	0.3	-0.7	-0.2
Leg fat-free mass (left)	0.7	3.7	6.2	2.5	-2.0	-2.0	-2.0	-0.4
Current tobacco smoking	0.7	1.1	4.1	2.0	0.4	-0.2	0.4	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.7	3.1	-1.8	1.5	0.9	1.5	0.1
Qualifications: CSEs or equivalent	0.7	0.9	2.1	0.3	1.0	1.5	1.0	0.5
Hayfever, allergic rhinitis or eczema	0.7	1.6	6.0	-2.5	-0.7	-0.7	-0.7	-0.4
High blood pressure (mother)	0.7	1.0	4.2	2.1	0.2	0.6	0.2	-0.3
Leg predicted mass (left)	0.7	3.5	5.8	2.4	-2.0	-2.0	-2.0	-0.4
Trunk fat mass	0.7	2.9	4.4	0.8	-1.6	-2.1	-1.6	-2.1
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	2.9	1.7	0.7	-0.2	0.7	0.5
Alcohol intake versus 10 years previously	0.7	1.1	2.5	-1.6	-0.6	-1.5	-0.6	0.2
Happiness	0.7	0.8	1.9	0.6	1.3	0.2	1.4	-0.1
Exposure to tobacco smoke at home	0.7	0.7	2.1	0.1	-0.8	-0.6	-0.8	-1.5
Peak expiratory flow (PEF)	0.7	1.5	6.2	-0.3	-0.9	-0.2	-0.8	-2.5
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	2.6	0.2	-1.6	-0.7	-1.5	-1.3
Health satisfaction	0.7	0.9	3.9	2.0	0.2	0.2	0.1	0.6
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.8	0.5	1.0	0.0	1.0	1.3
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.9	-0.3	0.9	1.4	0.9	0.6
Leg fat-free mass (right)	0.7	3.9	6.6	2.6	-2.1	-2.0	-2.1	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.9	0.9	0.9	-0.1	0.9	1.7
Mineral and other dietary supplements	0.7	1.0	3.7	-0.8	0.5	-0.1	0.3	1.9
Leg predicted mass (right)	0.7	3.8	6.6	2.6	-2.0	-2.0	-2.0	-0.3
Financial situation satisfaction	0.7	0.9	3.0	-0.2	0.8	-0.3	0.7	1.7
Breast Cancer	0.6	1.5	2.6	1.6	1.2	1.0	1.2	1.0
Mean Putamen Volume	0.6	0.7	3.0	1.7	0.3	-0.4	0.2	0.5
Ulcerative Colitis	0.6	0.8	3.2	1.8	-0.3	0.7	-0.4	0.3
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.0	1.4	-0.3	0.7	-0.4	-1.1
Ever had hysterectomy (womb removed)	0.6	0.7	1.1	1.0	0.8	0.7	0.8	0.8
Vitamin and mineral supplements	0.6	0.8	2.4	0.0	-0.4	1.1	-0.5	1.5
Diabetes (father)	0.6	0.7	3.2	-1.8	0.2	-0.4	0.2	-0.3
Trunk fat percentage	0.6	2.6	5.4	-0.2	-1.4	-1.9	-1.4	-2.3
Supplements: Glucosamine	0.6	0.7	2.2	0.7	0.2	1.0	0.4	-1.5
Alcohol usually taken with meals	0.6	1.0	3.9	0.5	0.0	0.9	0.1	-2.0
Had menopause	0.6	0.7	2.1	0.6	-0.6	-0.4	-0.7	-1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	2.5	-1.6	1.3	0.5	1.2	-0.9
Allergy	0.6	1.4	4.7	2.2	1.0	0.3	1.0	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.9	-0.2	1.0	0.2	1.0	1.4
Medication: Seretide 50 evohaler	0.6	0.7	2.2	0.7	0.4	1.5	0.5	0.5
Whole body fat mass	0.6	2.5	4.5	0.8	-1.4	-2.1	-1.4	-1.8
Supplements: Vitamin C	0.6	0.7	2.2	0.1	-0.7	-1.5	-0.6	-0.5
Illnesses of siblings: Diabetes	0.6	0.7	1.4	0.7	-1.1	-0.8	-1.2	-0.1
Whole body fat-free mass	0.6	3.3	9.2	3.0	-1.4	-1.8	-1.4	-0.1
Eye problems/disorders: Cataract	0.6	0.7	2.3	-1.5	0.8	0.0	0.8	-0.5
Medication for cholesterol	0.6	0.8	3.4	0.1	-0.6	0.2	-0.6	1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.4	2.3	-0.5	-1.5	-1.3	-1.5	-0.5
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.4	0.1	-0.8	-1.2	-0.8	-0.9
Supplements: Fish oil (including cod liver oil)	0.6	0.8	3.3	0.8	-0.1	0.2	-0.0	-1.8
Basal metabolic rate	0.6	3.4	8.4	2.9	-1.6	-2.0	-1.5	-0.3
Arm fat-free mass (left)	0.6	3.2	6.3	2.5	-1.4	-2.4	-1.3	-0.6
Diastolic blood pressure, automated reading	0.6	1.9	4.5	-0.9	0.2	-2.0	0.2	-2.1
Arm predicted mass (left)	0.6	3.0	7.3	2.7	-1.2	-2.2	-1.1	-0.3
Schizophrenia vs Biploar Disorder	0.5	0.6	1.1	1.0	-0.4	-1.0	-0.3	-1.0
Alzheimer’s Disease (in father)	0.5	0.5	2.0	0.4	0.5	0.2	0.5	1.4
Ulcerative Colitis (UC)	0.5	0.9	3.6	1.9	-0.4	0.5	-0.5	0.3
BMI	0.5	2.9	5.0	0.2	-2.1	-2.2	-2.1	-0.6
Systolic Blood Pressure	0.5	2.5	3.8	-1.8	1.9	-0.8	1.9	-1.1
Lung FEV1/FVC ratio	0.5	2.3	4.7	-0.1	2.1	1.1	2.2	-1.0
Hearing difficulty/problems: Yes	0.5	0.8	2.0	-1.4	-0.8	-0.8	-0.8	0.4
Average weekly fortified wine intake	0.5	0.6	1.5	1.1	0.4	1.2	0.4	0.4
Taking other prescription medications	0.5	0.7	2.7	0.3	-0.5	0.6	-0.4	-1.6
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.8	0.6	-0.1	-1.3	-0.2	0.8
Medication: Atenolol	0.5	0.7	1.2	-0.7	1.1	0.7	1.0	-0.4
Number of incorrect matches in round	0.5	0.8	3.0	1.7	0.5	-0.1	0.6	-0.7
Had other major operations	0.5	0.7	1.6	0.6	0.2	-1.1	0.2	-1.3
Weight	0.5	2.6	4.4	2.1	-1.4	-1.8	-1.4	-1.1
Arm fat percentage (right)	0.5	2.1	4.0	0.0	-1.4	-1.6	-1.4	-2.0
Trunk fat-free mass	0.5	3.1	11.2	3.3	-1.0	-1.5	-1.0	0.2
Arm fat mass (right)	0.5	2.1	3.8	1.0	-1.2	-2.0	-1.2	-1.6
Trunk predicted mass	0.5	3.1	11.4	3.4	-1.0	-1.5	-0.9	0.3
Standing height	0.5	5.0	8.9	3.0	-2.3	-2.2	-2.2	-1.0
Length of working week for main job	0.5	0.5	1.2	1.1	-0.4	0.0	-0.5	-1.0
Body fat percentage	0.5	2.1	4.5	-0.0	-1.3	-1.7	-1.2	-2.1
Arm fat-free mass (right)	0.5	2.7	6.4	2.5	-1.1	-2.2	-1.1	-0.2
Eye problems/disorders: None of the above	0.5	0.6	1.6	1.3	-0.7	-0.2	-0.7	0.6
Migraine (self-reported)	0.5	0.7	1.6	0.8	-0.7	0.5	-0.7	1.3
Medication: Allopurinol	0.5	0.7	1.0	-1.0	-0.5	-0.9	-0.5	-1.0
Leg fat mass (right)	0.5	2.0	3.6	1.1	-1.3	-1.9	-1.3	-1.3
Arm predicted mass (right)	0.5	2.5	6.1	2.5	-1.0	-2.0	-1.0	0.1
Pulse rate, automated reading	0.5	1.5	2.3	-1.5	1.4	-1.0	1.4	0.0
Medication: Aspirin	0.5	0.6	1.9	1.4	0.2	1.0	0.1	0.1
Whole body water mass	0.5	3.0	8.2	2.9	-1.4	-1.8	-1.4	0.1
Arm fat mass (left)	0.5	2.2	3.6	1.0	-1.4	-1.9	-1.4	-1.6
Medication: Blood pressure	0.5	0.9	2.0	-0.2	1.4	0.5	1.4	-0.7
Illnesses of father: High blood pressure	0.5	0.7	2.1	0.6	0.2	0.9	0.2	1.4
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.5	-0.9	-0.6	-0.4	-0.6	-1.2
Pack years of smoking	0.5	0.8	1.8	-0.4	1.3	-0.4	1.3	0.3
Leg fat mass (left)	0.5	1.8	3.7	1.1	-1.2	-1.9	-1.2	-1.2
Waist Hip Ratio (WHR)	0.4	1.8	3.3	0.4	1.8	1.3	1.8	1.0
Supplements: Zinc	0.4	0.5	1.3	1.2	0.3	-0.6	0.3	-0.8
Pack years adult smoking proportion	0.4	0.6	1.2	-0.2	1.1	-0.8	1.1	0.3
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.4	1.2	-0.5	-0.5	-0.6	0.0
Chronic bronchitis/emphysema (father)	0.4	0.4	1.0	0.7	0.4	1.0	0.4	-0.6
Illnesses of siblings	0.4	0.5	1.2	-0.3	-1.1	-0.5	-1.0	-0.3
Impedance of arm (right)	0.4	2.0	4.6	-1.8	-1.0	-0.4	-0.9	-2.1
Noisy workplace	0.4	0.5	1.1	0.6	-1.0	0.1	-1.1	-0.5
Illnesses of mother	0.4	0.5	1.2	-1.1	0.6	0.6	0.7	-0.1
Pulse wave reflection index	0.4	0.5	1.6	0.2	-0.5	0.6	-0.4	1.3
Blood clot in the leg (DVT)	0.4	0.6	1.3	-0.8	-0.6	-0.5	-0.6	-1.2
Glaucoma (self-reported)	0.4	0.4	1.3	-0.7	-0.0	0.6	-0.1	1.1
Comparative body size at age 10	0.4	1.2	1.3	-1.1	1.1	1.2	1.0	1.1
Age at first live birth	0.4	0.7	2.2	-1.5	-0.3	-1.0	-0.2	-0.0
Shortness of breath walking on level ground	0.4	0.5	1.0	1.0	0.8	0.2	0.8	0.1
Medication: Ibuprofen	0.4	0.5	2.1	-0.4	0.3	-0.5	0.3	1.4
Medication: Omeprazole	0.4	0.5	0.8	-0.6	0.9	0.2	0.9	0.8
Comparative height size at age 10	0.4	2.0	2.9	1.6	-1.7	-0.7	-1.6	-1.2
Hypertension (Self-reported)	0.4	1.0	2.3	0.4	1.5	0.7	1.4	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	2.0	-1.4	0.1	-0.1	0.0	0.7
Arm fat percentage (left)	0.4	1.6	2.9	0.1	-1.3	-1.3	-1.3	-1.7
Asthma (self-reported)	0.4	0.9	1.4	-1.0	-1.2	-0.4	-1.2	0.5
Osteoporosis (self-reported)	0.4	0.5	1.7	-0.0	-0.6	0.1	-0.6	-1.3
Medication: Bendroflumethiazide	0.4	0.6	1.6	0.4	0.7	0.3	0.7	-1.3
Medication: Atorvastatin	0.4	0.5	0.9	-1.0	0.5	-0.8	0.6	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.7	-0.5	0.9	0.5	0.8	0.8
Fasting Glucose	0.3	0.4	0.8	0.4	-0.5	0.8	-0.5	-0.9
LDL Cholesterol	0.3	0.4	1.0	-1.0	-0.4	-0.5	-0.4	-0.8
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	0.6	-0.4	0.7	0.4	0.8	0.6
Hand grip strength (right)	0.3	0.9	2.2	-0.8	-0.8	-1.5	-0.9	-0.4
Relative age voice broke	0.3	0.4	1.4	0.2	-0.5	1.2	-0.5	-0.6
Heart attack	0.3	0.4	0.8	0.9	-0.3	0.9	-0.4	0.5
Pain all over the body in last month	0.3	0.4	1.0	1.0	0.4	0.2	0.4	-0.6
Hip circumference	0.3	1.4	2.6	1.6	-1.2	-0.9	-1.1	-0.9
Impedance of arm (left)	0.3	1.2	3.5	-1.9	-0.5	0.3	-0.5	-1.4
Headache pain in last month	0.3	0.4	1.1	0.8	0.3	1.0	0.3	0.5
High blood pressure (siblings)	0.3	0.5	1.3	-0.2	0.6	0.6	0.5	-1.1
Wheeze or whistling in the chest in last year	0.3	0.6	2.4	0.5	-0.3	0.3	-0.4	1.6
Medication: Blood pressure	0.3	0.4	1.7	1.3	-0.1	0.4	-0.2	0.6
Number of full sisters	0.3	0.3	0.7	-0.8	0.3	-0.2	0.3	0.8
Age at last live birth	0.3	0.5	0.9	-0.9	-0.1	-0.8	-0.1	1.0
Medication: Aspirin	0.3	0.4	1.4	1.2	0.2	0.8	0.2	0.0
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.5	0.0	-0.0	1.2	-0.1	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.9	0.6	0.4	1.0	0.5	-0.2
Heart attack/myocardial infarction (self-reported)	0.3	0.3	1.0	1.0	-0.3	0.6	-0.5	0.2
Prostate Cancer	0.2	0.2	0.6	0.2	0.1	0.8	0.1	0.7
Body Mass Index (BMI) (2010)	0.2	0.3	0.5	0.5	-0.7	0.1	-0.7	0.3
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.6	0.8	0.5	-0.0	0.6	0.3
Blood White Count	0.2	1.3	6.1	2.5	0.0	0.2	-0.0	-0.7
Tanning	0.2	2.7	12.0	1.2	-0.4	0.0	-0.3	-3.5
Medication: Metformin	0.2	0.3	0.4	0.0	-0.6	-0.6	-0.6	-0.3
Impedance of leg (right)	0.2	0.8	2.1	-1.5	0.5	0.0	0.6	-1.2
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.9	1.0	0.4	-0.1	0.3	0.1
High blood pressure	0.2	0.7	1.6	0.0	1.3	0.5	1.2	-0.2
Medication: Levothyroxine sodium	0.2	0.3	0.7	-0.2	-0.8	-0.2	-0.8	-0.4
Body mass index (BMI)	0.2	0.7	1.3	0.8	-0.5	-1.1	-0.5	-0.9
Impedance of leg (left)	0.2	0.8	1.9	-1.4	0.5	-0.2	0.6	-1.1
Hearing difficulty/problems with background noise	0.2	0.3	1.2	0.3	-0.4	0.1	-0.4	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.6	-0.5	0.3	0.8	0.2	-0.2
Tense / ‘highly strung’	0.2	0.3	0.5	0.7	0.5	0.3	0.6	0.5
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.7	-0.5	-0.3	-0.3	-0.3	0.8
Birth weight	0.2	0.5	0.7	-0.4	0.9	0.7	0.8	0.8
Leg fat percentage (right)	0.2	0.9	2.4	0.5	-0.5	-1.1	-0.5	-1.5
Commuting to job workplace: Walk	0.2	0.2	0.8	-0.5	0.2	0.9	0.1	0.1
Leg fat percentage (left)	0.2	0.8	2.1	0.6	-0.4	-1.2	-0.3	-1.4
Average weekly beer plus cider intake	0.2	0.3	0.7	-0.7	-0.2	-0.8	-0.2	-0.5
Fractured/broken bones in last 5 years	0.2	0.3	0.5	0.4	0.3	0.6	0.3	-0.7
Age started oral contraceptive pill	0.2	0.2	0.9	-0.4	0.2	0.3	0.2	-0.9
Cholesterol lowering medication	0.2	0.3	0.6	0.0	0.8	-0.4	0.7	-0.7
Impedance of whole body	0.2	1.2	4.0	-2.0	-0.0	-0.1	0.0	-1.5
Ovarian Cancer	0.1	0.2	0.5	-0.2	0.4	0.1	0.4	0.7
Blood Eosinophil Count	0.1	0.7	1.6	1.2	-0.4	-1.3	-0.5	-0.6
Blood Platelet Count	0.1	1.5	2.6	-0.6	1.6	1.2	1.6	0.5
Height	0.1	2.8	10.6	3.2	-0.9	0.2	-0.8	1.3
Hypothyroidism (self reported)	0.1	0.2	0.6	-0.3	-0.3	0.4	-0.3	-0.7
Hand grip strength (left)	0.1	0.3	0.7	-0.8	0.1	0.1	0.1	0.8
Angina	0.1	0.1	0.4	-0.6	0.2	0.4	0.2	-0.1
Waist circumference	0.1	0.5	2.1	1.4	-0.1	-0.4	-0.1	-0.4
Hair/balding pattern: Pattern 4	0.1	0.3	0.6	-0.8	0.4	0.6	0.4	0.0
Angina (self-reported)	0.1	0.1	0.2	-0.4	0.2	0.5	0.2	-0.2
Alcohol intake frequency.	0.1	0.3	1.0	1.0	-0.1	0.7	-0.1	0.3
Ever had bowel cancer screening	0.1	0.1	0.2	0.3	0.3	-0.2	0.3	-0.4
Medication: Gliclazide	0.1	0.1	0.3	-0.5	0.1	-0.1	0.1	-0.1
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.5	-0.2	-0.7	-0.4	-0.7	0.4
Hair Pigment	0.0	0.8	1.3	1.1	0.8	-0.7	0.7	1.0
Eye problems/disorders: Glaucoma	0.0	0.0	0.1	-0.2	-0.2	0.1	-0.3	-0.1

Hub : Genes

SLC12A5

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Trait associations