Best TWAS P=1.13e-11 · Best GWAS P=5.86e-22 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | GUCA1A | 0.19 | 0.17 | enet | 16 | 0.19 | 7.9e-23 | -4.4 | -6.6 | 3.4e-11 | -0.35 | 1.00 | 0.00 | TRUE |
2 | GTEx | Artery Aorta | GUCA1B | 0.16 | 0.09 | lasso | 3 | 0.07 | 1.5e-04 | 6.1 | -5.9 | 4.3e-09 | -0.61 | 0.68 | 0.08 | FALSE |
3 | GTEx | Nerve Tibial | UBR2 | 0.14 | 0.09 | lasso | 3 | 0.07 | 6.9e-06 | -5.8 | -5.6 | 2.1e-08 | -0.02 | 0.99 | 0.00 | FALSE |
4 | GTEx | Skin Sun Exposed Lower leg | GUCA1B | 0.12 | 0.12 | lasso | 2 | 0.09 | 6.5e-08 | 5.6 | 5.5 | 3.3e-08 | 0.78 | 0.98 | 0.02 | FALSE |
5 | GTEx | Testis | CCND3 | 0.25 | -0.01 | lasso | 6 | 0.00 | 1.8e-01 | -2.9 | 5.2 | 1.7e-07 | 0.03 | 0.07 | 0.04 | TRUE |
6 | GTEx | Uterus | PRPH2 | 0.37 | 0.03 | enet | 7 | 0.04 | 4.9e-02 | -4.7 | 6.8 | 1.1e-11 | 0.00 | 0.08 | 0.06 | TRUE |
7 | NTR | Blood | MRPS10 | 0.03 | 0.02 | lasso | 9 | 0.02 | 1.3e-06 | 5.8 | 5.5 | 3.1e-08 | 0.74 | 0.47 | 0.53 | TRUE |
8 | ROSMAP | Brain Pre-frontal Cortex | MRPS10 | 0.30 | 0.32 | lasso | 10 | 0.31 | 3.2e-41 | 5.6 | 5.7 | 1.5e-08 | 0.81 | 1.00 | 0.00 | TRUE |
9 | ROSMAP | Brain Pre-frontal Cortex | GUCA1A | 0.25 | 0.18 | lasso | 3 | 0.20 | 2.1e-25 | -4.4 | -6.3 | 3.0e-10 | -0.34 | 1.00 | 0.00 | FALSE |
10 | ROSMAP | Brain Pre-frontal Cortex | PGC | 0.13 | 0.06 | blup | 520 | 0.06 | 3.2e-08 | -1.5 | 5.2 | 2.1e-07 | 0.25 | 1.00 | 0.00 | TRUE |
11 | YFS | Blood | TRERF1 | 0.06 | 0.01 | bslmm | 464 | 0.03 | 8.5e-11 | -7.2 | -6.6 | 4.1e-11 | 0.24 | 0.95 | 0.03 | TRUE |
12 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | GUCA1B | 0.18 | 0.19 | lasso | 8 | 0.18 | 4.3e-15 | 3.8 | -5.4 | 6.7e-08 | -0.60 | 1.00 | 0.00 | TRUE |
13 | The Cancer Genome Atlas | Esophageal Carcinoma | GUCA1B | 0.31 | 0.15 | lasso | 5 | 0.18 | 3.3e-06 | 6.1 | -6.6 | 3.7e-11 | -0.70 | 0.31 | 0.34 | FALSE |
14 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | GUCA1B | 0.18 | 0.12 | blup | 63 | 0.15 | 6.1e-09 | 5.3 | -6.5 | 1.1e-10 | -0.63 | 0.93 | 0.07 | FALSE |
15 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | GUCA1B | 0.25 | 0.25 | blup | 63 | 0.27 | 5.4e-08 | 2.8 | -5.6 | 2.8e-08 | -0.63 | 0.45 | 0.51 | FALSE |