TWAS hub - TRERF1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Thyroid	0.2170	0.0550	8.2e-06	0.042	NA	0.092	NA	0.083	0.00037	NA	1.6e-07	NA	6.4e-07
2	YFS	Blood	0.0637	0.0165	2.4e-08	0.007	0.030	0.030	0.032	0.026	0.00200	3.1e-10	3.0e-10	8.5e-11	3.6e-09
3	TCGA	Prostate Adenocarcinoma	0.0348	0.0177	7.7e-03	0.004	0.004	-0.002	NA	-0.001	0.11000	1.2e-01	5.4e-01	NA	3.9e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Heart disease (mother)	3.9	4.8	6.6	-2.2	2.6	-1.7
Number of children fathered	3.4	3.9	6.4	-1.3	1.9	-2.5
Emphysema/chronic bronchitis	3.4	3.8	4.8	2.1	-2.2	1.5
Number of live births	3.3	4.6	5.3	2.2	-2.3	1.9
Ever had hysterectomy (womb removed)	3.2	3.6	8.7	-0.8	3.0	-1.2
Tinnitus: Yes, but not now, but have in the past	2.7	2.9	5.9	1.7	2.4	0.3
Blood Eosinophil Count	2.6	19.9	43.6	3.8	-6.6	-1.3
Type 2 Diabetes (T2D) (2018)	2.5	4.7	7.0	-1.1	2.4	-2.6
Maternal smoking around birth	2.5	3.6	5.1	1.9	-1.5	2.3
Back pain experienced in last month	2.5	3.7	6.8	-0.6	1.9	-2.6
Peak expiratory flow (PEF)	2.4	5.6	11.7	1.4	-1.7	3.4
Blood White Count	2.3	17.4	49.5	-1.4	7.0	-0.9
Mouth/teeth dental problems: Dentures	2.3	3.9	6.6	-1.3	2.6	-1.9
Diabetes diagnosed by doctor	2.3	3.9	5.0	-1.7	1.9	-2.2
Ever smoked	2.3	4.1	8.0	1.4	-1.5	2.8
Other serious medical condition/disability diagnosed by doctor	2.2	2.8	4.2	-1.6	2.1	-1.3
Diabetes (self-reported)	2.2	3.5	4.8	-1.4	1.9	-2.2
Long-standing illness, disability or infirmity	2.1	3.3	5.9	-1.3	1.5	-2.4
Illnesses of mother	2.0	2.4	3.0	1.7	-1.6	1.3
Number of operations (self-reported)	2.0	3.0	4.6	-1.3	1.6	-2.1
Major Depression (MDD)	1.9	2.3	3.8	1.2	-1.9	1.2
Had other major operations	1.9	2.3	3.4	-1.0	1.6	-1.9
Number of full brothers	1.9	2.3	3.3	1.0	-1.6	1.8
Age at last live birth	1.9	2.7	4.6	-2.1	1.2	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	1.9	2.0	4.7	0.9	2.2	0.7
Chest pain or discomfort	1.8	2.6	3.9	2.0	-1.2	1.5
Commuting to job workplace: Cycle	1.8	2.2	6.1	0.6	2.5	-0.5
Coronary Artery Disease (CAD)	1.7	2.1	5.3	0.9	2.3	0.3
Primary Biliary Cirrhosis	1.7	2.4	7.0	0.4	-0.2	2.7
Average weekly fortified wine intake	1.7	2.0	3.3	-1.2	1.8	-1.1
Eye problems/disorders: Cataract	1.7	2.0	4.6	-0.3	1.1	-2.2
Multivitamins +/- minerals	1.6	2.0	4.5	-2.1	-1.2	0.0
Migraine (self-reported)	1.6	2.0	5.0	0.9	-0.2	2.2
Schizophrenia (2018)	1.5	3.1	7.6	-1.1	2.8	0.7
Supplements: Zinc	1.5	1.6	3.4	1.9	-1.0	0.6
Diabetes (mother)	1.5	1.9	4.9	-2.2	0.8	-0.5
Myopia	1.5	2.2	4.2	1.5	-0.4	2.0
Eye problems/disorders: Diabetes related eye disease	1.4	1.6	2.1	-1.3	1.4	-1.0
Pulse rate	1.4	2.4	5.4	-0.9	1.0	-2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	2.4	-1.1	-1.2	-1.5
Illnesses of siblings: Diabetes	1.4	1.8	3.6	1.9	-1.3	0.0
Guilty feelings	1.4	2.0	4.4	-0.9	1.0	-2.1
Age started oral contraceptive pill	1.4	1.7	3.8	-1.9	1.2	0.0
Deep venous thrombosis (DVT) (self-reported)	1.4	1.7	3.9	2.0	-0.4	1.1
Alcohol drinker status: Previous	1.4	1.6	2.5	-1.3	1.6	-0.8
Bipolar Disorder or Schizophrenia	1.3	3.3	7.6	-1.5	2.8	0.4
Blood Red Count	1.3	12.9	34.7	-1.7	-5.9	1.0
Hair/balding pattern: Pattern 4	1.3	3.2	6.2	-1.0	2.5	-1.6
Health satisfaction	1.3	1.7	2.9	1.7	-1.3	-0.7
Heart disease (siblings)	1.3	1.6	3.1	1.2	1.8	0.4
Diabetes (father)	1.2	1.5	2.6	1.1	-1.6	0.9
Past tobacco smoking	1.2	2.3	4.6	-1.3	0.7	-2.2
Happiness	1.2	1.4	2.2	1.5	-1.4	0.4
Miserableness	1.2	2.1	4.4	-2.1	0.2	-1.3
Medication: Co-codamol	1.1	1.3	1.8	1.3	-1.4	0.7
Lung cancer (father)	1.1	1.3	1.9	0.6	1.4	-1.2
Blood clot in the leg (DVT)	1.1	1.4	3.1	1.8	-0.3	1.0
Leg fat percentage (right)	1.1	3.8	7.5	-2.7	0.5	-1.9
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	2.8	-0.9	0.4	-1.7
Smoking Status	1.0	2.4	5.9	1.2	0.2	2.4
Hearing difficulty/problems: Yes	1.0	1.5	2.8	-1.2	0.7	-1.7
Medication: Metformin	1.0	1.5	2.8	-1.1	0.6	-1.7
Hayfever, allergic rhinitis or eczema	1.0	2.1	4.6	-1.3	0.2	-2.1
Hearing difficulty/problems with background noise	1.0	1.5	2.4	-1.6	0.5	-1.4
Loud music exposure frequency	1.0	1.1	3.1	1.8	-0.2	0.4
Age at first live birth	1.0	1.8	3.9	-2.0	0.6	-1.0
Eye problems/disorders: None of the above	1.0	1.1	1.8	0.8	-1.0	1.3
Leg pain on walking	1.0	1.3	2.0	-1.2	0.7	-1.4
Ever taken oral contraceptive pill	1.0	1.1	2.6	0.6	-0.5	1.6
HbA1C	0.9	1.0	2.9	-1.7	-0.2	-0.4
Current tobacco smoking	0.9	1.5	3.8	0.8	-0.3	2.0
Supplements: Glucosamine	0.9	1.2	2.9	-0.8	-1.7	0.3
Fluid intelligence score	0.9	1.8	3.7	0.6	-1.2	1.9
Medication: Lansoprazole	0.9	1.1	2.8	-1.7	0.0	-0.7
Medication: Aspirin	0.9	1.2	2.9	-0.4	1.7	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	4.5	0.9	-0.1	2.1
Mood swings	0.9	1.6	2.6	-0.7	1.3	-1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	2.1	-0.1	1.4	-1.1
Mineral and other dietary supplements	0.9	1.2	1.6	1.0	0.9	1.3
Smoking status: Current	0.9	1.5	4.1	0.5	0.1	2.0
Mother’s age at death	0.9	1.1	2.9	-0.6	-0.4	-1.7
Supplements: Fish oil (including cod liver oil)	0.9	1.1	2.2	-1.5	-0.9	-0.7
Alzheimer’s Disease (in mother)	0.8	0.9	2.2	0.3	-0.7	1.5
Body Mass Index (BMI) (2010)	0.8	1.1	2.0	-1.2	-0.2	1.4
Schizophrenia (2014)	0.8	1.7	3.5	-0.8	1.9	1.0
Vitamin and mineral supplements	0.8	1.1	2.3	1.5	0.7	0.7
Trunk fat percentage	0.8	3.3	8.2	-2.9	0.9	-0.9
Age when periods started (menarche)	0.8	1.9	2.9	-0.6	-1.7	1.6
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	1.8	-0.4	1.3	-1.0
Prospective memory result	0.8	1.0	1.3	-0.9	0.9	-1.1
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	1.5	0.5	-1.0	1.2
Medication: Aspirin	0.8	1.0	1.8	0.3	1.4	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	4.7	0.1	-0.5	-2.2
Pain type(s) experienced in last month: Hip pain	0.8	1.1	1.7	-1.3	-0.8	-1.0
Leg fat percentage (left)	0.8	3.0	5.7	-2.4	0.8	-1.7
Pain experienced in last month	0.8	1.4	2.3	1.4	-0.2	1.5
Breast Cancer	0.7	1.8	3.7	-1.2	1.9	-0.5
Frequency of depressed mood in last 2 weeks	0.7	1.0	3.0	1.7	0.1	0.1
Severe depression (siblings)	0.7	0.8	1.8	-0.5	1.3	-0.7
Alcohol usually taken with meals	0.7	1.2	3.5	0.3	-0.2	1.9
Qualifications: None of the above	0.7	1.4	1.7	1.3	-1.2	1.1
Medication: Simvastatin	0.7	1.0	1.7	-0.6	1.3	-1.0
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.7	1.0	-0.0	1.3
Birth weight	0.7	1.5	3.6	-1.9	0.8	-0.5
Body fat percentage	0.7	2.9	7.2	-2.7	0.6	-1.1
Number of full sisters	0.7	0.9	2.2	1.5	-0.5	0.4
Ever had bowel cancer screening	0.7	0.9	1.5	-0.4	-1.0	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.7	1.0	2.5	0.8	-1.6	-0.0
High cholesterol (Self-reported)	0.7	1.2	3.3	-0.0	1.8	-0.6
Medication: Bendroflumethiazide	0.7	1.0	2.2	0.6	-1.5	0.7
Unable to work because of sickness or disability	0.7	0.9	1.5	1.2	-0.5	0.9
Cholesterol lowering medication	0.7	1.0	2.9	-0.2	1.7	-0.3
Bipolar Disorder (2018)	0.6	1.0	1.5	-1.1	1.2	-0.4
Mean Putamen Volume	0.6	0.7	1.3	0.9	1.1	-0.0
Systolic Blood Pressure	0.6	3.0	5.3	1.9	2.3	-0.3
Average weekly spirits intake	0.6	0.7	1.4	0.5	-0.6	-1.2
Serious illness, injury or assault to yourself	0.6	0.7	1.3	0.1	-1.0	-1.1
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.2	-1.1	0.6	-0.8
Hair/balding pattern: Pattern 2	0.6	0.8	1.2	0.5	-0.9	1.1
Heart attack	0.6	0.8	1.9	0.3	1.4	0.5
Arm fat percentage (right)	0.6	2.2	5.8	-2.4	-0.6	-0.7
Hip circumference	0.6	2.8	6.6	-2.6	0.0	-1.3
Time employed in main current job	0.6	0.7	2.0	0.1	1.4	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	2.1	0.7	-1.5	0.4
Hair/balding pattern: Pattern 3	0.6	0.8	1.0	0.9	-0.9	1.0
Medication: Seretide 50 evohaler	0.6	0.7	1.4	0.7	0.2	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.2	-0.7	1.1	-0.5
Knee pain experienced in last month	0.6	0.9	1.0	-0.9	-0.9	-1.0
Arm fat percentage (left)	0.6	2.2	5.5	-2.3	-0.3	-1.0
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.1	0.7	-0.6	1.1
Friendships satisfaction	0.6	0.8	1.7	1.3	0.4	0.6
Financial situation satisfaction	0.6	0.8	1.4	1.2	0.2	-0.9
Average weekly beer plus cider intake	0.6	0.8	1.7	-0.7	0.5	-1.3
Fractured/broken bones in last 5 years	0.6	0.8	2.4	1.6	0.1	0.2
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.6	-0.8	-0.1	-1.3
Lupus	0.5	0.7	1.9	-1.4	0.4	0.4
Neuroticism (2016)	0.5	0.7	1.3	-0.7	0.6	-1.2
Angina	0.5	0.6	0.9	0.9	0.9	-0.3
Fed-up feelings	0.5	0.8	1.3	0.9	1.1	-0.6
High blood pressure (mother)	0.5	0.7	2.0	-0.1	0.4	-1.4
Trunk fat mass	0.5	2.1	5.4	-2.3	0.4	-0.8
Number of incorrect matches in round	0.5	0.8	1.2	-0.4	-1.0	-1.1
Had menopause	0.5	0.6	1.3	-1.1	-0.4	0.7
Pain all over the body in last month	0.5	0.6	1.2	1.1	0.4	0.6
Illnesses of siblings	0.5	0.7	1.9	-1.4	-0.2	0.4
Depression (self-reported)	0.5	0.6	1.7	1.3	-0.1	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	2.4	0.6	-1.6	1.3
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.4	-0.4	-1.2	-0.6
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.2	0.7	-0.9	1.1
Forced vital capacity (FVC), Best measure	0.5	1.9	2.7	0.9	-1.6	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.5	1.3	-0.1	1.1	0.6
Leg fat mass (right)	0.5	1.8	4.4	-2.1	0.1	-1.0
Smoking status: Previous	0.5	0.7	1.5	1.2	0.2	0.7
Commuting to job workplace: Walk	0.5	0.5	1.4	-0.3	1.2	-0.0
Hearing aid user	0.5	0.6	1.3	0.6	-0.3	-1.1
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.8	0.2	1.3	0.4
Alzheimer’s Disease (in father)	0.4	0.4	1.0	-1.0	0.5	-0.0
Ulcerative Colitis (UC)	0.4	0.8	1.9	1.4	0.5	-0.6
Rheumatoid Arthritis	0.4	0.6	1.7	1.3	0.3	0.2
Type 2 Diabetes (T2D) (2012)	0.4	0.4	0.8	-0.1	0.9	-0.7
Allergy or Eczema	0.4	1.1	2.6	-0.8	-0.5	-1.6
Cardiovascular Disease	0.4	1.5	3.0	0.9	1.7	0.7
Respiratory disease	0.4	0.9	2.1	1.5	0.1	-0.6
Ever used hormone-replacement therapy (HRT)	0.4	0.5	0.7	-0.5	-0.8	0.9
Systolic blood pressure, automated reading	0.4	1.1	1.7	0.5	1.3	-1.1
Medication for hormone replacement therapy	0.4	0.5	0.6	0.8	0.8	0.4
Hand grip strength (right)	0.4	1.1	2.1	-1.4	-0.2	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	0.7	0.8	-0.1	0.9
Relative age voice broke	0.4	0.6	1.1	-0.5	0.6	1.1
Taking other prescription medications	0.4	0.7	1.6	0.4	0.5	-1.3
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.5	-0.1	1.2	-0.0
Body mass index (BMI)	0.4	1.9	4.6	-2.1	-0.6	-0.9
Impedance of leg (left)	0.4	1.9	4.9	0.7	2.2	0.5
Waist circumference	0.4	1.4	3.8	-1.9	-0.0	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.8	-0.1	0.1	-1.4
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.6	0.2	-1.3	-0.0
Financial difficulties in last 2 years	0.4	0.6	1.4	0.5	1.2	0.5
Medication: Ramipril	0.4	0.5	1.1	1.0	0.2	-0.5
Father’s age at death	0.4	0.5	0.9	0.9	0.1	-0.9
Worrier / anxious feelings	0.4	0.8	1.5	0.3	1.2	-1.0
Falls in the last year	0.4	0.5	1.2	-0.5	1.1	-0.3
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	2.5	0.2	-1.6	1.3
Medication: Cholesterol lowering	0.4	0.6	1.0	-0.3	1.0	-0.8
Breastfed as a baby	0.4	0.5	1.5	0.2	-1.2	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	0.7	0.7	0.8	0.8
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.3	0.8	-0.2	1.1
Headache pain in last month	0.4	0.7	1.8	1.4	-0.3	-0.4
Glaucoma (self-reported)	0.4	0.4	0.8	0.0	0.9	0.7
Medication: Amlodipine	0.4	0.6	0.7	0.6	0.8	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.9	-0.4	0.9	0.7
Wheeze or whistling in the chest in last year	0.4	0.6	0.8	0.9	0.9	-0.5
Shortness of breath walking on level ground	0.4	0.4	1.0	-0.5	-0.2	-1.0
Medication: Allopurinol	0.4	0.6	1.2	-1.1	-0.6	-0.2
Medication: Omeprazole	0.4	0.5	0.9	0.5	-0.6	-1.0
Mean time to correctly identify matches	0.4	0.7	0.9	0.7	0.9	-1.0
Whole body fat mass	0.4	1.7	4.8	-2.2	-0.2	-0.5
Suffer from ‘nerves’	0.4	0.6	1.5	-0.6	0.1	-1.2
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.1	0.4	-1.0	0.4
Loneliness, isolation	0.4	0.5	1.0	0.7	-1.0	0.1
Asthma (self-reported)	0.4	0.8	2.3	1.5	0.5	0.1
Average weekly champagne plus white wine intake	0.4	0.5	1.0	-0.8	1.0	-0.1
Commuting to job workplace: Public transport	0.4	0.5	1.0	0.3	1.0	-0.7
Medication: Blood pressure	0.4	0.8	1.2	0.6	-0.9	1.1
Illnesses of father: High blood pressure	0.4	0.5	1.5	-0.1	-1.2	0.3
Impedance of whole body	0.4	1.9	5.5	0.2	2.3	0.6
Leg fat mass (left)	0.4	1.6	4.0	-2.0	0.2	-0.8
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.0	-1.4	0.7	0.4
Irritable Bowel Disease (IBD)	0.3	0.7	1.7	1.3	0.5	-0.4
Verbal and Numeric Reasoning (VNR)	0.3	0.8	2.1	-0.2	-0.5	1.4
Crohns Disease (2012)	0.3	0.5	1.4	0.3	1.2	-0.3
HDL Cholesterol	0.3	0.5	1.0	-0.1	0.6	-1.0
Triglycerides	0.3	0.5	0.9	-1.0	0.4	-0.7
Ulcerative Colitis	0.3	0.4	0.9	0.9	-0.6	-0.3
Blood Platelet Count	0.3	3.7	5.7	0.0	2.4	-2.3
BMI	0.3	1.7	3.1	-1.8	-1.3	-0.3
Waist Hip Ratio (WHR)	0.3	1.3	2.9	1.7	0.5	0.8
Lung FVC	0.3	1.6	4.5	-0.5	-2.1	-0.0
Chronotype (morning person)	0.3	0.7	1.5	-0.7	0.4	-1.2
Townsend deprivation index at recruitment	0.3	0.5	0.7	-0.6	-0.8	0.6
Stomach or abdominal pain in last month	0.3	0.4	1.0	1.0	-0.4	-0.2
Forced vital capacity (FVC)	0.3	1.2	2.8	0.1	-1.7	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.3	1.1	-0.5	0.5
Impedance of arm (right)	0.3	1.3	2.3	0.1	1.3	1.5
Noisy workplace	0.3	0.4	0.9	0.9	0.2	-0.4
Asthma	0.3	0.6	1.8	1.3	0.2	0.2
Arm fat mass (right)	0.3	1.3	2.8	-1.7	-1.0	-0.2
Length of working week for main job	0.3	0.3	0.6	0.4	0.5	-0.8
Exposure to tobacco smoke outside home	0.3	0.4	1.0	-0.1	-0.5	-1.0
Worry too long after embarrassment	0.3	0.5	1.3	-1.1	0.1	0.2
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.8	0.4	-0.1	0.9
Medication for pain relief, constipation, heartburn	0.3	0.5	0.7	-0.8	-0.8	0.6
Neck or shoulder pain in last month	0.3	0.4	1.0	-0.2	-1.0	-0.5
Family relationship satisfaction	0.3	0.4	0.7	0.6	0.8	-0.2
Supplements: Vitamin C	0.3	0.4	1.0	0.2	0.3	-1.0
Medication: Gliclazide	0.3	0.3	0.9	-0.9	0.1	-0.2
Arm fat mass (left)	0.3	1.3	3.2	-1.8	-0.8	-0.4
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.6	-0.2	0.7	-0.8
Ever depressed for a whole week	0.3	0.3	0.9	-0.9	0.2	-0.2
Pack years of smoking	0.3	0.4	1.0	-1.0	0.4	-0.4
Depressed Affect (Nagel 2018)	0.2	0.4	0.8	-0.4	0.3	-0.9
Neuroticism (Nagel 2018)	0.2	0.5	0.5	-0.7	0.6	-0.7
Schizophrenia vs Biploar Disorder	0.2	0.3	0.6	0.8	0.1	0.4
Crohns Disease (2017)	0.2	0.4	1.0	0.3	1.0	-0.5
Reaction Time	0.2	0.3	0.8	0.9	0.4	-0.1
Fasting Glucose	0.2	0.2	0.6	-0.8	0.1	-0.3
LDL Cholesterol	0.2	0.3	0.8	-0.1	-0.4	-0.9
Lung FEV1/FVC ratio	0.2	0.9	2.5	-0.3	0.2	1.6
Tanning	0.2	2.0	2.9	-1.7	0.9	-1.5
Hand grip strength (left)	0.2	0.5	1.0	-0.5	-0.5	-1.0
Number of treatments/medications taken	0.2	0.3	0.5	0.7	-0.2	-0.6
Sensitivity / hurt feelings	0.2	0.3	0.6	-0.5	-0.2	0.8
Pack years adult smoking proportion	0.2	0.3	0.6	-0.7	0.7	-0.2
Impedance of leg (right)	0.2	1.2	3.5	0.2	1.9	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.7	0.8	0.1	0.8
Qualifications: CSEs or equivalent	0.2	0.2	0.4	0.5	-0.7	0.1
Weight	0.2	0.8	2.3	-1.5	-0.3	-0.0
Pulse wave Arterial Stiffness index	0.2	0.2	0.3	0.5	0.3	0.4
Impedance of arm (left)	0.2	1.1	2.5	0.1	1.6	0.9
Standing height	0.2	2.4	5.2	1.4	0.2	2.3
Exposure to tobacco smoke at home	0.2	0.3	0.3	-0.5	-0.5	-0.5
Tense / ‘highly strung’	0.2	0.4	0.6	-0.7	0.8	-0.3
Pulse wave reflection index	0.2	0.3	0.6	-0.1	0.4	0.8
Medication: Paracetamol	0.2	0.3	0.5	0.7	-0.3	0.5
Gout (self-reported)	0.2	0.3	0.6	-0.0	-0.6	0.8
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.6	0.2	-0.2	-0.8
Angina (self-reported)	0.2	0.3	0.6	0.6	0.8	0.0
Alcohol intake frequency.	0.2	0.5	1.2	-0.5	-1.1	0.2
Comparative height size at age 10	0.2	1.1	2.3	0.8	0.5	1.5
Overall health rating	0.2	0.5	1.5	0.2	0.0	-1.2
Had major operations	0.2	0.3	0.6	0.7	-0.3	0.4
Illnesses of father: Heart disease	0.2	0.3	0.9	-0.2	-0.9	-0.1
Average weekly red wine intake	0.2	0.3	0.5	-0.7	0.3	0.7
Qualifications: nursing, teaching	0.2	0.4	1.0	0.3	0.0	-1.0
Breast cancer (self-reported)	0.2	0.2	0.5	-0.3	0.1	-0.7
Illnesses of father: None of the above (group 1)	0.2	0.2	0.4	0.6	0.6	-0.1
Number of self-reported non-cancer illnesses	0.2	0.4	0.7	-0.4	0.8	-0.5
Wears glasses or contact lenses	0.2	0.3	0.5	0.6	0.2	-0.7
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.6	-0.1	0.3	0.8
Medication: Paracetamol	0.2	0.4	0.8	0.9	-0.3	0.4
Alcohol drinker status: Never	0.2	0.2	0.5	0.4	-0.7	-0.4
Risk taking	0.2	0.3	0.9	0.2	0.2	1.0
Diastolic blood pressure, automated reading	0.2	0.8	1.2	-1.1	-0.0	-1.1
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.1	-0.6	-1.1	-0.6
Basal cell carcinoma (self-reported)	0.2	0.2	0.5	0.3	-0.4	-0.7
Depression (Nagel 2018)	0.1	0.2	0.5	0.7	-0.0	0.3
Worry (Nagel 2018)	0.1	0.1	0.2	0.3	0.5	-0.2
Age at First Birth	0.1	0.1	0.2	-0.4	0.2	0.0
Heel T-Score	0.1	1.1	2.7	-1.6	-0.7	0.3
Height	0.1	2.0	3.4	1.9	0.5	1.6
Hypothyroidism (self reported)	0.1	0.2	0.4	0.4	-0.6	0.0
Neuroticism	0.1	0.3	0.7	-0.8	0.4	0.4
Relative age of first facial hair	0.1	0.1	0.3	-0.3	0.6	0.1
Leg fat-free mass (left)	0.1	0.6	0.8	-0.9	-0.8	0.5
High blood pressure	0.1	0.3	0.3	0.5	0.5	0.6
Medication: Levothyroxine sodium	0.1	0.2	0.3	0.6	-0.2	0.6
Sitting height	0.1	0.9	2.5	0.4	1.6	0.4
Chronic bronchitis/emphysema (father)	0.1	0.2	0.4	-0.0	-0.7	-0.3
Leg predicted mass (left)	0.1	0.5	0.7	-0.8	-0.8	0.5
Nervous feelings	0.1	0.1	0.1	0.4	0.3	-0.4
Mouth/teeth dental problems	0.1	0.1	0.3	0.5	-0.2	0.2
Allergy	0.1	0.3	0.7	0.1	0.5	0.8
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.3	0.4	-0.1	-0.6
Neuroticism score	0.1	0.3	0.6	-0.4	0.8	-0.4
Alcohol intake versus 10 years previously	0.1	0.2	0.2	0.4	-0.4	0.4
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.4	0.3	-0.6	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	0.5	-0.2	-0.0
Birth weight of first child	0.1	0.2	0.4	-0.4	-0.3	0.6
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.3	-0.6	-0.2	-0.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.5	0.7	-0.1	0.2
High blood pressure (siblings)	0.1	0.1	0.3	0.3	-0.0	-0.5
Comparative body size at age 10	0.1	0.4	0.7	-0.7	-0.8	-0.2
Pulse wave peak to peak time	0.1	0.1	0.2	-0.2	-0.5	-0.2
Qualifications: College or University degree	0.1	0.2	0.5	-0.7	0.2	0.3
Medication: Blood pressure	0.1	0.2	0.5	-0.2	0.7	-0.5
Medication: Ibuprofen	0.1	0.2	0.3	0.6	0.2	-0.4
Pulse rate, automated reading	0.1	0.4	0.5	-0.7	0.7	0.5
Hypertension (Self-reported)	0.1	0.3	0.5	0.5	0.2	0.7
Leg fat-free mass (right)	0.1	0.5	0.9	-0.5	-0.7	1.0
Medication for cholesterol	0.1	0.1	0.2	-0.4	-0.4	-0.2
Osteoporosis (self-reported)	0.1	0.1	0.3	0.4	-0.1	0.5
Osteoarthritis (self-reported)	0.1	0.2	0.3	0.3	0.3	-0.5
Whole body water mass	0.1	0.3	0.6	-0.3	-0.8	0.4
Leg predicted mass (right)	0.1	0.5	0.9	-0.4	-0.7	1.0
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	0.2	0.2	0.4
Medication: Lisinopril	0.1	0.1	0.2	0.1	0.3	0.4
Medication: Atorvastatin	0.1	0.2	0.3	0.2	0.4	-0.5
Basal metabolic rate	0.1	0.4	0.6	-0.6	-0.8	0.4
Irritability	0.1	0.2	0.4	-0.6	0.6	-0.2
Supplements: Calcium	0.1	0.1	0.2	0.2	0.1	0.4
Alzheimer’s Disease (including proxy)	0.0	0.0	0.1	-0.3	0.2	-0.0
Ovarian Cancer	0.0	0.0	0.1	-0.1	-0.1	0.3
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.4	0.6	0.4	-0.8	0.7
Medication: Atenolol	0.0	0.0	0.0	0.0	0.1	0.0
Trunk fat-free mass	0.0	0.3	0.6	0.1	-0.8	0.4
Trunk predicted mass	0.0	0.2	0.5	0.0	-0.7	0.2
Arm fat-free mass (right)	0.0	0.1	0.2	-0.4	-0.2	-0.0
Arm predicted mass (right)	0.0	0.1	0.2	-0.4	-0.1	-0.1
Whole body fat-free mass	0.0	0.2	0.4	-0.4	-0.7	0.3
Arm fat-free mass (left)	0.0	0.1	0.2	-0.2	-0.5	0.1
Arm predicted mass (left)	0.0	0.1	0.2	-0.5	-0.3	-0.2

Hub : Genes

TRERF1

Models

Trait associations