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chr6:33,662,667-36,804,187

Best TWAS P=2.39e-22 · Best GWAS P=8.03e-22 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ANKS1A	0.15	0.12	lasso	7	0.12	2.4e-14	-7.0	-7.5	7.7e-14	-0.12	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SRPK1	0.08	0.06	lasso	4	0.06	1.6e-07	-6.3	-6.2	4.8e-10	0.10	0.99	0.00	FALSE
3	GTEx	Adipose Subcutaneous	RPL10A	0.06	0.02	enet	27	0.03	2.6e-03	6.4	6.3	3.6e-10	0.14	0.32	0.04	FALSE
4	GTEx	Artery Aorta	ANKS1A	0.10	0.10	lasso	2	0.08	2.4e-05	-6.5	-6.8	1.4e-11	-0.10	0.20	0.51	FALSE
5	GTEx	Artery Tibial	RPL10A	0.11	0.08	lasso	2	0.09	1.5e-07	4.3	5.3	1.0e-07	0.05	1.00	0.00	FALSE
6	GTEx	Brain Caudate basal ganglia	SRPK1	0.20	0.08	lasso	5	0.10	7.4e-04	-7.6	-8.6	5.3e-18	0.12	0.33	0.04	TRUE
7	GTEx	Brain Cerebellar Hemisphere	SRPK1	0.33	0.09	lasso	19	0.09	2.3e-03	-6.6	-6.1	1.1e-09	0.23	0.34	0.06	FALSE
8	GTEx	Cells Transformed fibroblasts	TEAD3	0.36	0.29	enet	27	0.32	8.4e-25	-8.3	9.7	2.4e-22	0.21	1.00	0.00	TRUE
9	GTEx	Colon Transverse	RPL10A	0.12	0.05	lasso	4	0.05	2.5e-03	4.3	6.5	6.6e-11	0.12	0.28	0.04	FALSE
10	GTEx	Esophagus Muscularis	NUDT3	0.12	0.00	lasso	7	0.02	3.2e-02	-4.4	6.0	2.5e-09	-0.06	0.11	0.22	TRUE
11	GTEx	Heart Atrial Appendage	TEAD3	0.17	0.08	lasso	6	0.09	1.1e-04	-6.5	8.0	8.9e-16	0.21	0.56	0.04	FALSE
12	GTEx	Heart Atrial Appendage	MAPK13	0.12	0.00	lasso	5	0.00	3.1e-01	4.9	-6.6	4.3e-11	0.15	0.06	0.12	FALSE
13	GTEx	Lung	RPL10A	0.21	0.09	enet	53	0.09	1.2e-07	4.0	5.7	1.3e-08	0.15	0.95	0.00	FALSE
14	GTEx	Skin Not Sun Exposed Suprapubic	TEAD3	0.15	0.06	lasso	5	0.08	2.5e-05	7.6	7.8	9.0e-15	0.03	0.78	0.01	FALSE
15	GTEx	Testis	ZNF76	0.15	0.14	enet	8	0.12	4.4e-06	5.4	-6.4	1.6e-10	-0.04	0.94	0.01	FALSE
16	GTEx	Thyroid	RPL10A	0.16	0.09	lasso	11	0.07	8.9e-06	5.8	5.5	3.9e-08	0.04	0.89	0.01	FALSE
17	METSIM	Adipose	PPARD	0.04	0.00	enet	19	0.01	3.9e-03	-7.8	8.4	4.5e-17	0.08	0.10	0.03	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	TEAD3	0.07	0.03	bslmm	421	0.04	5.6e-06	-4.6	8.8	1.9e-18	0.17	0.78	0.02	TRUE
19	ROSMAP	Brain Pre-frontal Cortex	DEF6	0.04	0.02	bslmm	421	0.02	1.8e-03	2.1	-5.3	9.9e-08	-0.09	0.80	0.01	TRUE
20	ROSMAP	Brain Pre-frontal Cortex	ANKS1A	0.18	0.18	lasso	5	0.16	1.3e-20	-7.0	-7.4	1.3e-13	-0.13	0.73	0.27	FALSE
21	ROSMAP	Brain Pre-frontal Cortex	PACSIN1	0.09	0.00	blup	359	0.02	4.5e-04	-2.0	-6.5	1.1e-10	-0.07	0.16	0.19	TRUE
22	ROSMAP	Brain Pre-frontal Cortex	LHFPL5	0.12	0.17	enet	9	0.17	3.4e-21	-6.5	6.9	5.0e-12	-0.12	1.00	0.00	TRUE
23	YFS	Blood	FANCE	0.01	0.00	blup	385	0.00	3.1e-01	-5.2	8.3	1.1e-16	-0.17	0.10	0.02	FALSE
24	YFS	Blood	SRPK1	0.06	0.05	bslmm	433	0.06	2.0e-18	-7.7	-8.5	2.7e-17	-0.05	1.00	0.00	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	LHFPL5	0.06	0.02	blup	53	0.06	1.6e-11	-5.6	5.8	6.1e-09	-0.10	0.04	0.96	FALSE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	TCP11	0.03	0.03	blup	49	0.04	6.6e-08	6.3	6.4	1.2e-10	-0.03	0.03	0.97	FALSE
27	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TCP11	0.07	0.01	enet	8	0.01	8.2e-02	7.8	7.7	1.3e-14	0.01	0.01	0.88	FALSE
28	The Cancer Genome Atlas	Colon Adenocarcinoma	SRPK1	0.04	0.03	blup	55	0.02	1.6e-02	-7.7	7.7	1.4e-14	-0.11	0.03	0.67	FALSE
29	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TCP11	0.03	0.00	blup	49	0.01	8.8e-03	7.6	8.5	1.2e-17	0.05	0.01	0.88	FALSE
30	The Cancer Genome Atlas	Brain Lower Grade Glioma	SRPK1	0.03	0.02	blup	57	0.01	7.4e-03	-7.8	8.3	1.3e-16	-0.10	0.04	0.84	FALSE
31	The Cancer Genome Atlas	Brain Lower Grade Glioma	TCP11	0.05	0.04	blup	49	0.06	1.3e-07	7.6	5.4	5.8e-08	-0.06	0.02	0.98	FALSE
32	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	TCP11	0.22	0.16	enet	8	0.15	1.9e-07	-6.8	-5.9	3.2e-09	-0.15	0.16	0.84	FALSE
33	The Cancer Genome Atlas	Lung Adenocarcinoma	C6orf81	0.05	0.00	blup	43	0.02	8.9e-04	-4.3	7.4	1.1e-13	0.09	0.01	0.60	TRUE
34	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TCP11	0.03	0.03	blup	49	0.03	3.5e-04	7.6	5.5	4.3e-08	-0.04	0.01	0.96	FALSE
35	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TCP11	0.05	0.07	lasso	2	0.07	1.9e-05	7.5	7.5	6.7e-14	-0.01	0.02	0.96	FALSE
36	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TCP11	0.08	0.11	lasso	2	0.11	3.4e-05	7.5	7.5	5.1e-14	0.00	0.02	0.94	FALSE
37	The Cancer Genome Atlas	Prostate Adenocarcinoma	TCP11	0.03	0.03	lasso	3	0.04	3.8e-05	6.3	6.1	8.6e-10	-0.02	0.02	0.93	FALSE
38	The Cancer Genome Atlas	Rectum Adenocarcinoma	SRPK1	0.11	0.05	enet	29	0.07	1.2e-02	-7.8	7.9	2.6e-15	-0.11	0.02	0.64	FALSE
39	The Cancer Genome Atlas	Thyroid Carcinoma	C6orf126	0.22	0.19	lasso	3	0.19	2.9e-18	-5.6	-5.4	8.7e-08	0.11	1.00	0.00	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	SRPK1	0.05	0.04	blup	57	0.04	5.0e-05	-7.7	6.9	4.5e-12	-0.13	0.04	0.95	TRUE