TWAS hub - UBR2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.110	0.0460	6.6e-03	-0.004	NA	0.025	NA	-0.004	9.2e-01	NA	5.3e-03	NA	8.1e-01
2	GTEx	Esophagus Muscularis	0.121	0.0440	2.6e-03	0.041	NA	0.023	NA	0.052	1.5e-03	NA	1.5e-02	NA	4.0e-04
3	GTEx	Nerve Tibial	0.137	0.0433	2.0e-04	0.091	NA	0.073	NA	0.073	5.8e-07	NA	7.2e-06	NA	6.9e-06
4	ROSMAP	Brain Pre-frontal Cortex	0.106	0.0241	3.8e-09	0.110	0.086	0.108	0.104	0.108	5.0e-14	3.2e-11	8.8e-14	2.8e-13	9.6e-14
5	TCGA	Pheochromocytoma and Paraganglioma	0.096	0.0580	5.5e-03	0.007	0.042	0.014	NA	0.013	1.6e-01	9.1e-03	9.1e-02	NA	9.6e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Coronary Artery Disease (CAD)	6.3	7.5	10.2	2.9	2.9	3.2	2.6	1.9
Ever had hysterectomy (womb removed)	5.0	5.6	12.8	1.3	1.8	3.6	2.0	2.5
Tinnitus: Yes, but not now, but have in the past	4.6	4.9	8.6	2.2	2.1	2.9	1.8	1.9
Major Depression (MDD)	3.4	4.1	10.6	2.4	1.2	0.7	3.3	-1.5
Hip circumference	3.0	13.0	35.5	-2.2	-1.1	-4.7	1.1	-6.0
Arm fat mass (left)	3.0	12.4	32.0	-2.5	-1.3	-4.6	0.9	-5.7
Arm fat mass (right)	2.9	11.8	31.1	-2.4	-1.2	-4.4	1.1	-5.6
Arm fat percentage (right)	2.8	11.1	27.1	-2.5	-1.3	-4.4	0.7	-5.2
Leg fat mass (right)	2.8	10.9	31.8	-2.1	0.0	-3.7	2.0	-5.6
Breast Cancer	2.7	6.5	14.0	3.7	1.6	2.8	1.3	2.6
Arm fat percentage (left)	2.7	10.7	26.3	-2.4	-1.3	-4.4	0.7	-5.1
Leg fat percentage (right)	2.6	9.5	26.5	-2.1	0.2	-3.4	2.2	-5.2
Worry too long after embarrassment	2.5	4.1	7.5	2.7	-0.1	2.4	0.4	2.7
Leg fat mass (left)	2.5	9.6	28.1	-1.8	0.1	-3.5	2.0	-5.3
Schizophrenia (2018)	2.4	5.0	10.0	-0.2	2.9	3.2	1.5	2.0
Body mass index (BMI)	2.4	10.4	29.6	-1.7	-0.6	-4.2	1.3	-5.4
Serious illness, injury or assault of a close relative in last 2 years	2.4	2.8	7.8	-2.8	-0.2	-1.5	-1.8	-0.7
Ever highly irritable/argumentative for 2 days	2.4	2.9	9.6	0.4	-3.1	-1.3	-1.8	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.4	2.8	9.1	3.0	-1.0	1.1	-0.2	1.7
Whole body fat mass	2.4	10.0	25.9	-2.5	-1.0	-4.0	1.1	-5.1
Family relationship satisfaction	2.4	3.0	8.2	2.9	1.2	1.5	1.1	1.3
Illnesses of siblings	2.3	3.2	6.2	2.5	-1.1	1.1	-1.3	2.4
Exposure to tobacco smoke at home	2.3	2.6	5.2	-0.8	-1.3	-2.1	-2.3	-0.8
Breast cancer (self-reported)	2.3	2.7	5.2	0.4	2.2	1.9	2.3	0.3
Bipolar Disorder or Schizophrenia	2.2	5.5	12.9	0.5	2.0	3.6	0.6	3.1
Blood Eosinophil Count	2.2	16.6	31.5	-2.6	-4.6	-5.6	-3.4	-3.4
BMI	2.2	12.9	36.4	-2.0	-0.3	-4.8	1.2	-6.0
Trunk fat mass	2.1	9.1	23.6	-2.5	-0.7	-3.7	1.2	-4.9
Blood White Count	2.0	14.8	35.1	1.1	5.9	4.2	3.7	2.5
Weight	2.0	9.7	27.8	-2.1	-0.6	-3.8	1.3	-5.3
Ever taken oral contraceptive pill	2.0	2.3	4.8	0.2	-1.9	-2.2	-1.1	-1.4
Leg fat percentage (left)	2.0	7.4	20.9	-1.6	0.3	-3.0	2.1	-4.6
Ever had bowel cancer screening	1.9	2.2	3.5	-1.5	-1.6	-1.9	-1.4	-0.8
Eye problems/disorders: Glaucoma	1.9	2.3	5.9	0.6	-2.4	-0.1	-2.1	1.0
Risk taking	1.9	2.8	5.4	2.2	-0.1	1.8	-0.5	2.3
Impedance of leg (left)	1.8	8.8	20.2	0.9	1.4	4.5	0.9	4.5
Body fat percentage	1.8	7.3	18.8	-2.2	-0.7	-3.3	1.2	-4.3
Medication: Ibuprofen	1.8	2.1	3.3	1.1	1.6	1.7	1.8	0.8
Illnesses of siblings: Diabetes	1.8	2.3	4.6	-2.1	0.2	-1.2	0.8	-2.1
Medication: Atorvastatin	1.8	2.2	4.0	-0.0	-1.8	0.8	-1.8	2.0
Irritability	1.8	3.0	5.1	2.2	0.9	2.0	0.8	2.0
Waist circumference	1.7	6.1	16.9	-1.5	-0.4	-3.2	0.7	-4.1
Depression (self-reported)	1.7	2.1	7.1	2.7	-0.0	1.2	0.8	1.1
Back pain experienced in last month	1.7	2.5	4.6	1.0	1.8	2.1	1.3	1.3
Alcohol drinker status: Previous	1.7	1.9	4.5	2.1	1.2	1.3	0.6	1.3
Ulcerative Colitis	1.6	2.3	4.3	0.2	-1.7	-2.1	-1.2	-1.7
Smoking Status	1.6	3.8	7.3	2.5	-0.7	2.1	-0.4	2.7
Number of full brothers	1.6	2.0	3.5	-1.9	-1.1	-1.7	-1.0	-1.3
Commuting to job workplace: Walk	1.6	1.7	3.1	1.5	1.3	1.2	-0.2	1.8
Rheumatoid Arthritis	1.5	2.0	6.0	-0.5	0.9	-1.3	1.2	-2.4
Leg fat-free mass (left)	1.5	7.8	23.0	-1.3	-0.6	-3.6	0.7	-4.8
Trunk fat percentage	1.5	6.2	15.1	-2.2	-0.7	-3.1	0.9	-3.9
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	2.7	1.6	-0.9	1.6	0.4	1.7
Leg predicted mass (left)	1.5	7.8	23.1	-1.4	-0.6	-3.6	0.7	-4.8
Falls in the last year	1.5	2.1	7.6	2.8	-0.1	0.7	-0.9	1.2
Breastfed as a baby	1.5	1.9	3.8	-1.1	-1.9	-1.3	-1.6	-0.4
Smoking status: Current	1.5	2.3	4.1	2.0	-0.7	1.3	-1.3	1.9
Average weekly champagne plus white wine intake	1.5	2.1	5.2	2.3	1.0	0.7	2.0	-0.0
Basal metabolic rate	1.5	8.1	24.5	-1.6	-0.5	-3.4	1.1	-5.0
Age started oral contraceptive pill	1.5	1.9	3.9	-0.3	1.3	2.0	0.3	1.9
Impedance of whole body	1.5	7.8	22.9	0.6	0.8	3.9	-0.4	4.8
Bipolar Disorder (2018)	1.4	2.3	6.3	1.0	-0.4	1.8	-0.9	2.5
Depression (Nagel 2018)	1.4	2.1	6.9	2.6	0.3	1.4	1.3	0.6
HDL Cholesterol	1.4	2.4	7.6	2.8	0.6	1.3	1.3	0.7
Sensitivity / hurt feelings	1.4	2.5	4.9	1.8	-1.5	1.2	-0.9	2.2
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	3.3	0.9	1.2	1.8	1.6	0.9
Current tobacco smoking	1.4	2.3	3.7	1.8	-1.0	1.1	-1.5	1.9
Average weekly fortified wine intake	1.4	1.6	2.5	1.3	1.0	1.6	0.9	1.4
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	4.5	0.8	-2.1	-0.9	-1.7	-0.1
Systolic Blood Pressure	1.3	6.3	11.9	2.4	1.3	3.4	1.5	3.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	3.1	1.6	1.8	1.2	1.7	0.2
Medication: Aspirin	1.3	1.7	3.4	-0.3	1.5	1.8	0.7	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.6	2.4	-1.4	-1.0	-1.4	-1.6	-0.6
High cholesterol (Self-reported)	1.3	2.4	5.9	0.6	0.0	2.4	0.4	2.4
Neuroticism (Nagel 2018)	1.2	2.8	4.6	1.8	0.5	2.1	1.3	2.0
Impedance of leg (right)	1.2	5.9	14.6	0.4	1.5	3.8	1.2	3.4
Age when periods started (menarche)	1.2	2.8	7.6	-2.8	-1.7	-1.3	-1.3	-0.6
Ever unenthusiastic/disinterested for a whole week	1.2	1.4	3.6	1.9	-0.7	-0.4	1.1	-1.3
Pulse rate	1.2	2.0	4.1	2.0	0.5	1.1	1.9	0.9
Medication: Aspirin	1.2	1.5	3.1	-0.3	1.4	1.8	0.6	1.5
Whole body water mass	1.2	6.8	20.7	-1.4	-0.6	-3.2	0.9	-4.5
Pain type(s) experienced in last month: Hip pain	1.2	1.5	3.7	-0.5	0.8	-1.5	0.6	-1.9
Commuting to job workplace: Cycle	1.2	1.5	1.8	1.4	1.3	1.3	1.3	0.7
Relative age of first facial hair	1.1	2.3	5.6	-0.4	-2.0	-0.7	-2.4	1.0
Multivitamins +/- minerals	1.1	1.4	2.9	1.6	-1.7	-0.2	-1.1	0.5
Fluid intelligence score	1.1	2.2	5.1	0.4	-1.6	-1.7	-2.3	-0.5
Trunk fat-free mass	1.1	6.2	18.9	-1.6	-0.4	-2.9	1.1	-4.3
Trunk predicted mass	1.1	6.2	18.7	-1.5	-0.5	-2.9	1.1	-4.3
High blood pressure (siblings)	1.1	1.6	3.5	-1.9	1.3	-0.1	1.4	-0.9
Whole body fat-free mass	1.1	6.5	19.9	-1.4	-0.5	-3.1	1.0	-4.5
Leg fat-free mass (right)	1.1	5.7	16.7	-1.0	-0.6	-3.2	0.5	-4.1
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	1.5	0.9	1.1	1.2	1.0	1.1
Qualifications: nursing, teaching	1.1	1.7	5.1	-0.2	-0.4	-1.7	-0.5	-2.2
Guilty feelings	1.1	1.7	3.5	1.3	0.5	1.9	0.9	1.5
Ever depressed for a whole week	1.1	1.3	5.4	2.3	-0.3	0.5	1.0	-0.1
Arm predicted mass (left)	1.1	5.6	17.2	-1.3	-0.5	-2.8	1.0	-4.2
LDL Cholesterol	1.0	1.6	5.8	-2.4	-0.6	-1.0	-0.2	-1.0
Waist Hip Ratio (WHR)	1.0	4.4	10.7	1.2	1.6	2.7	0.0	3.3
Relative age voice broke	1.0	1.5	2.5	0.6	-1.5	0.5	-1.4	1.6
Number of incorrect matches in round	1.0	1.7	4.9	-0.6	-0.5	0.3	-2.2	1.7
Pain all over the body in last month	1.0	1.0	2.4	-0.3	1.5	1.3	0.5	0.9
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	4.2	0.2	-2.0	-0.6	-1.4	0.2
Neuroticism score	1.0	2.0	3.8	2.0	0.2	1.6	0.5	1.9
Mouth/teeth dental problems: Dentures	1.0	1.7	2.8	1.3	0.9	1.7	1.1	1.4
Impedance of arm (left)	1.0	4.6	14.9	0.2	0.2	2.5	-1.1	3.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	3.3	1.0	0.9	1.0	1.8	0.4
Leg predicted mass (right)	1.0	5.5	16.2	-1.0	-0.6	-3.1	0.4	-4.0
Illnesses of father: High blood pressure	1.0	1.2	1.8	1.0	-1.1	-1.3	-1.0	-0.9
Ever smoked	1.0	1.7	3.3	1.4	-1.0	1.2	-0.8	1.8
Arm fat-free mass (left)	1.0	5.2	16.3	-1.1	-0.5	-2.6	1.1	-4.0
Cholesterol lowering medication	1.0	1.5	3.7	1.0	-0.3	1.7	0.1	1.9
Pain experienced in last month	1.0	1.7	6.0	1.2	-2.4	0.3	-0.6	0.9
Alzheimer’s Disease (in father)	0.9	0.9	2.6	1.6	0.4	0.9	1.0	0.1
HbA1C	0.9	1.0	2.4	-1.5	0.2	-0.4	-1.6	0.1
Schizophrenia (2014)	0.9	2.1	4.2	-0.9	1.8	2.0	0.7	1.3
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.0	1.4	1.2	0.8	0.9	0.4
Neuroticism	0.9	2.1	4.9	1.3	0.2	1.8	0.7	2.2
Frequency of depressed mood in last 2 weeks	0.9	1.2	5.1	2.2	0.3	0.7	0.4	0.6
Maternal smoking around birth	0.9	1.3	3.0	-1.0	-0.2	-1.4	-0.6	-1.7
Serious illness, injury or assault to yourself	0.9	1.1	2.2	1.2	-1.5	-0.9	-0.3	-1.1
High blood pressure (mother)	0.9	1.3	2.6	-0.5	1.6	0.3	1.6	-1.0
Had menopause	0.9	1.1	2.1	0.9	0.8	1.4	0.1	1.4
Heart attack	0.9	1.1	1.6	-0.1	1.2	1.3	1.2	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	1.6	0.7	1.0	1.3	1.2	1.1
Tense / ‘highly strung’	0.9	1.5	3.2	1.8	1.3	1.1	1.1	0.7
Qualifications: O levels/GCSEs or equivalent	0.9	1.5	4.0	1.0	0.7	1.0	-1.1	2.0
Glaucoma (self-reported)	0.9	1.0	2.7	0.6	-0.3	0.8	-1.1	1.6
Comparative body size at age 10	0.9	2.5	7.8	0.0	0.1	-2.0	0.8	-2.8
Wheeze or whistling in the chest in last year	0.9	1.7	2.9	1.7	1.3	1.1	1.6	0.2
Mouth/teeth dental problems: Loose teeth	0.9	1.1	3.7	-0.5	1.9	-0.1	1.1	-0.7
Arm predicted mass (right)	0.9	4.5	14.1	-1.3	-0.1	-2.4	1.1	-3.8
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.1	0.6	1.4	1.1	1.5	0.1
Smoking status: Previous	0.9	1.4	2.0	1.4	-0.4	1.4	1.4	0.9
Medication: Gliclazide	0.9	1.0	2.9	-0.4	-0.9	-0.2	-1.7	1.0
Medication: Lisinopril	0.9	1.2	2.9	0.3	-1.2	-0.1	-1.7	1.1
Heart disease (siblings)	0.9	1.1	2.7	-0.6	1.6	1.1	1.2	0.2
Primary Biliary Cirrhosis	0.8	1.2	2.8	-0.3	-1.0	0.6	-1.3	1.7
Respiratory disease	0.8	1.8	5.0	0.2	1.2	-1.0	1.2	-2.2
Type 2 Diabetes (T2D) (2018)	0.8	1.4	3.9	-1.0	2.0	0.7	1.2	-0.4
Average weekly spirits intake	0.8	1.0	2.1	1.2	-1.4	-0.8	0.1	-0.8
Townsend deprivation index at recruitment	0.8	1.1	3.5	0.8	-1.9	-0.3	-1.0	0.4
Supplements: Glucosamine	0.8	1.1	3.0	0.7	-1.7	-1.0	-0.9	-0.5
Past tobacco smoking	0.8	1.5	3.2	-1.8	1.2	-1.2	-0.3	-1.3
Forced vital capacity (FVC)	0.8	3.0	4.4	-1.2	-1.9	-2.1	-1.9	-1.4
Impedance of arm (right)	0.8	3.9	12.7	0.4	-0.1	2.4	-1.0	3.6
Time employed in main current job	0.8	0.9	1.9	0.8	0.7	1.4	0.6	1.1
Arm fat-free mass (right)	0.8	4.3	13.8	-1.1	0.0	-2.2	1.3	-3.7
Health satisfaction	0.8	1.1	2.8	-0.3	-0.4	-1.3	0.8	-1.7
Mood swings	0.8	1.5	4.4	2.1	0.7	1.0	1.1	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	1.6	0.7	0.7	1.3	1.1	1.1
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.8	1.3	-0.1	1.0	0.2	1.2
Heart attack/myocardial infarction (self-reported)	0.8	1.0	1.6	0.3	0.9	1.3	1.1	1.1
Schizophrenia vs Biploar Disorder	0.7	0.9	2.9	-1.7	0.8	0.2	0.7	-0.5
Verbal and Numeric Reasoning (VNR)	0.7	1.6	4.0	2.0	-1.0	-1.1	-1.3	-0.2
Neuroticism (2016)	0.7	0.9	2.8	1.4	-1.7	0.0	0.2	-0.1
Lung FVC	0.7	3.4	7.9	-0.5	-2.6	-1.4	-2.8	0.1
Happiness	0.7	0.9	2.1	1.4	-1.2	0.4	0.7	0.2
Illnesses of mother	0.7	0.9	1.3	-1.0	-0.9	-1.1	-0.7	-1.0
Migraine (self-reported)	0.7	0.8	1.8	-0.2	1.3	0.2	1.3	-0.8
Pulse rate, automated reading	0.7	2.4	3.8	1.3	1.6	1.9	2.0	0.6
Suffer from ‘nerves’	0.7	1.0	3.5	0.5	-1.9	-0.8	-0.4	-0.7
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.7	-1.6	-0.1	-0.7	0.3	-1.0
Average weekly red wine intake	0.7	1.0	2.4	1.6	-1.1	-0.9	-0.7	-0.5
Osteoporosis (self-reported)	0.7	0.9	1.9	-0.6	-0.1	0.9	-1.1	1.4
Unable to work because of sickness or disability	0.7	0.9	2.3	0.3	-1.0	0.5	-1.0	1.5
Myopia	0.7	1.0	2.4	1.0	1.6	1.0	0.7	0.2
Blood Red Count	0.6	5.9	22.8	-4.8	1.6	-0.4	1.4	-1.4
Allergy or Eczema	0.6	1.5	3.9	0.1	-0.5	-2.0	0.2	-1.8
Systolic blood pressure, automated reading	0.6	1.6	2.9	1.5	-0.7	1.6	0.3	1.7
Vitamin and mineral supplements	0.6	0.8	2.5	-1.6	0.3	-0.4	0.5	-1.0
Diabetes (father)	0.6	0.7	1.4	-0.5	-1.0	0.6	-1.2	0.7
Fed-up feelings	0.6	1.1	2.1	1.1	0.4	1.3	0.5	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	3.0	1.7	-0.2	0.6	0.4	0.8
Chronic bronchitis/emphysema (father)	0.6	0.7	1.6	0.9	0.6	0.8	1.3	0.4
Alcohol usually taken with meals	0.6	0.9	1.6	1.3	1.0	1.1	0.5	0.7
Nervous feelings	0.6	1.2	3.5	-0.1	-0.7	0.5	-1.3	1.9
Hair/balding pattern: Pattern 3	0.6	0.9	2.0	-0.9	-0.9	-1.4	-0.4	-1.0
Medication: Lansoprazole	0.6	0.7	2.0	-0.1	0.7	0.9	1.4	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	4.1	0.1	-2.0	-1.5	-1.5	-0.6
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.2	-1.5	0.8	-0.6	-0.1	-0.5
Exposure to tobacco smoke outside home	0.6	0.8	3.4	1.8	-0.6	0.1	-0.3	0.4
Emphysema/chronic bronchitis	0.6	0.7	1.6	-0.6	-0.5	-1.1	0.2	-1.3
Eye problems/disorders: Cataract	0.6	0.7	2.0	-0.3	1.0	0.6	1.4	-0.1
Hearing aid user	0.6	0.6	1.8	0.2	-1.4	-0.9	0.2	-0.7
Mother’s age at death	0.6	0.8	1.6	-0.4	-1.1	-1.2	-0.6	-0.7
Financial situation satisfaction	0.6	0.7	2.7	1.6	-0.7	-0.6	-0.2	-0.1
Medication: Blood pressure	0.6	1.2	2.6	-0.1	-1.4	0.3	-1.2	1.6
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.7	-0.0	1.3	-0.3	1.1	-0.8
Basal cell carcinoma (self-reported)	0.6	0.7	2.3	-1.5	-0.8	-0.4	-0.4	-0.5
Intelligence (Savage-Jansen 2018)	0.5	1.4	6.3	2.5	-0.2	0.2	-0.4	0.6
Crohns Disease (2017)	0.5	1.1	2.4	1.0	-0.7	1.1	-0.4	1.6
Mean Putamen Volume	0.5	0.6	1.4	-0.2	-0.3	0.2	-1.2	1.2
Cardiovascular Disease	0.5	1.6	3.0	-0.1	1.7	1.4	0.9	1.4
Lung FEV1/FVC ratio	0.5	2.6	7.6	2.8	-0.6	1.7	0.9	1.2
Medication for hormone replacement therapy	0.5	0.6	1.1	-0.5	0.6	-0.5	1.1	-1.0
Supplements: Zinc	0.5	0.5	1.2	1.1	0.1	-0.5	0.7	-0.8
Diabetes (mother)	0.5	0.6	1.4	1.2	0.2	0.8	0.6	0.8
Severe depression (siblings)	0.5	0.5	1.8	1.3	-0.5	0.4	-0.2	0.7
Stomach or abdominal pain in last month	0.5	0.6	1.0	-0.1	-0.9	0.9	-0.6	1.0
Had other major operations	0.5	0.6	2.2	1.5	-0.7	0.1	-0.2	0.6
Father’s age at death	0.5	0.6	1.3	-0.0	-0.5	-1.1	-1.1	-0.5
Noisy workplace	0.5	0.7	1.5	-0.3	0.2	1.2	0.6	1.2
Birth weight of first child	0.5	0.8	1.7	-0.4	-1.1	-1.3	-0.4	-1.1
Medication: Amlodipine	0.5	0.7	1.8	-0.6	0.2	1.0	-0.3	1.3
Forced vital capacity (FVC), Best measure	0.5	1.8	3.8	-0.5	-1.9	-1.5	-1.5	-0.8
Comparative height size at age 10	0.5	2.5	6.8	-0.4	2.0	1.1	2.6	-0.7
Chest pain or discomfort	0.5	0.8	1.5	-0.8	0.6	1.1	-0.5	1.2
Age at last live birth	0.5	0.7	1.5	-0.1	1.2	-0.6	0.6	-1.1
Knee pain experienced in last month	0.5	0.8	2.1	0.0	-0.1	-1.4	-0.1	-1.5
Friendships satisfaction	0.5	0.6	1.4	1.2	-0.7	0.8	0.8	0.3
Mineral and other dietary supplements	0.5	0.7	1.2	-0.3	0.8	1.1	1.1	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.8	0.5	-1.7	-1.0	-0.9	-0.6
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.1	0.8	-0.5	-0.9	-1.0	-0.5
Vascular/heart problems diagnosed by doctor	0.5	1.3	3.7	-0.5	-0.9	-1.3	0.2	-1.9
Alzheimer’s Disease (including proxy)	0.4	0.6	1.7	1.3	-0.5	0.6	0.8	0.4
Ulcerative Colitis (UC)	0.4	0.7	1.7	0.6	-1.1	0.1	-1.3	0.6
Reaction Time	0.4	0.8	3.1	-1.8	-0.3	-0.3	-0.9	-0.1
Ovarian Cancer	0.4	0.5	1.1	0.5	1.0	-0.2	1.0	-0.3
Age at First Birth	0.4	0.6	1.3	-0.8	1.1	0.0	0.7	-0.7
Body Mass Index (BMI) (2010)	0.4	0.6	1.5	0.1	0.6	-0.2	1.2	-1.0
Fasting Glucose	0.4	0.5	1.1	1.0	-0.7	-0.0	-0.6	0.5
Angina	0.4	0.6	1.8	-0.7	1.4	0.4	0.6	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.1	-1.1	1.4	0.7	-0.3	0.5
Hair/balding pattern: Pattern 2	0.4	0.5	1.3	-0.4	0.8	-0.2	1.2	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	2.6	-1.6	0.6	-0.6	-0.9	-0.3
Allergy	0.4	0.9	2.2	-0.4	0.1	1.5	-0.3	1.4
Diabetes (self-reported)	0.4	0.6	1.2	-1.0	1.1	0.8	0.6	-0.0
Medication: Simvastatin	0.4	0.6	1.6	0.5	0.1	1.3	0.9	0.6
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	2.7	-0.1	-1.6	-1.4	-1.4	-0.7
Pulse wave reflection index	0.4	0.5	2.4	-1.6	0.2	-0.2	-0.3	-0.0
Headache pain in last month	0.4	0.7	2.2	0.0	0.2	-1.1	0.1	-1.5
Gout (self-reported)	0.4	0.5	1.4	0.7	0.2	-0.5	0.6	-1.2
Birth weight	0.4	0.9	2.9	1.7	-1.0	0.8	0.4	0.1
Number of children fathered	0.4	0.5	1.4	0.5	0.7	0.4	1.2	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.8	-0.5	1.3	0.3	0.1	0.1
Medication for pain relief, constipation, heartburn	0.4	0.7	1.4	0.1	-1.2	-1.0	-1.0	-0.4
Heart disease (mother)	0.4	0.4	0.9	0.4	0.4	1.0	0.7	0.7
Had major operations	0.4	0.4	1.1	-0.4	0.5	-0.8	0.1	-1.1
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.2	-0.1	-1.1	-0.1	-1.1	0.1
Long-standing illness, disability or infirmity	0.4	0.6	1.7	1.3	0.9	0.5	-0.0	0.6
Alcohol drinker status: Never	0.4	0.5	1.0	-0.3	0.5	-0.7	0.8	-1.0
Average weekly beer plus cider intake	0.4	0.6	1.9	-1.4	0.4	0.1	-0.5	0.7
Supplements: Calcium	0.4	0.4	1.7	1.3	-0.5	-0.1	-0.4	0.2
Depressed Affect (Nagel 2018)	0.3	0.7	1.1	1.1	0.2	1.0	0.9	0.8
Alzheimer’s Disease (in mother)	0.3	0.4	1.0	0.5	-1.0	0.3	0.4	0.5
Irritable Bowel Disease (IBD)	0.3	0.7	1.1	0.9	-0.9	0.6	-0.8	1.0
Chronotype (morning person)	0.3	0.7	1.9	1.1	-1.4	0.1	-0.3	0.6
Hand grip strength (left)	0.3	0.7	1.8	0.1	0.1	0.0	1.4	-1.3
Hearing difficulty/problems: Yes	0.3	0.5	0.9	0.7	-0.5	0.2	-0.9	0.8
Medication: Co-codamol	0.3	0.4	0.8	-0.2	-0.8	-0.9	-0.4	-0.5
Qualifications: CSEs or equivalent	0.3	0.4	1.0	-0.6	-0.3	-1.0	-0.4	-0.6
High blood pressure	0.3	0.8	2.6	0.2	0.4	0.8	-0.7	1.6
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.4	0.8	-0.1	-1.2	0.4	-1.0
Financial difficulties in last 2 years	0.3	0.4	0.8	0.9	-0.5	0.1	-0.8	0.7
Worrier / anxious feelings	0.3	0.5	1.6	0.4	1.3	0.7	0.6	0.4
Medication: Cholesterol lowering	0.3	0.5	1.1	-0.9	-0.5	0.7	-0.2	1.0
Pulse wave Arterial Stiffness index	0.3	0.3	0.7	0.3	0.0	0.7	0.4	0.8
Peak expiratory flow (PEF)	0.3	0.8	2.1	0.3	-1.5	-0.8	-1.0	-0.3
Medication: Paracetamol	0.3	0.5	1.3	0.6	0.6	-0.2	0.5	-1.2
Age at first live birth	0.3	0.6	1.2	-0.6	0.4	-1.0	-0.3	-1.1
Pulse wave peak to peak time	0.3	0.3	0.8	-0.3	-0.1	-0.8	-0.3	-0.9
Neck or shoulder pain in last month	0.3	0.5	1.0	-0.8	0.2	-1.0	-0.7	-0.6
Angina (self-reported)	0.3	0.4	1.4	-0.6	1.2	0.3	0.6	-0.1
Medication: Allopurinol	0.3	0.5	1.1	0.7	0.1	-0.2	0.8	-1.0
Medication: Seretide 50 evohaler	0.3	0.3	0.9	0.3	-0.1	-0.7	0.4	-0.9
Number of full sisters	0.3	0.4	1.0	1.0	-1.0	-0.4	-0.2	-0.3
Leg pain on walking	0.3	0.4	1.0	-1.0	0.1	-0.3	0.3	-1.0
Hypertension (Self-reported)	0.3	0.7	2.2	-0.5	-0.1	0.5	-0.9	1.5
Illnesses of father: Heart disease	0.3	0.4	1.2	-0.6	0.1	-0.5	0.3	-1.1
Diabetes diagnosed by doctor	0.3	0.5	1.2	0.0	0.8	1.1	0.6	0.4
Osteoarthritis (self-reported)	0.3	0.4	1.1	0.4	-1.1	-0.8	-0.3	-0.5
Illnesses of father: None of the above (group 1)	0.3	0.3	0.6	-0.4	-0.8	-0.3	-0.8	0.4
Number of self-reported non-cancer illnesses	0.3	0.5	1.7	1.3	0.2	-0.1	0.5	-0.5
Medication: Bendroflumethiazide	0.3	0.4	1.2	-0.4	-1.1	-0.4	-0.5	-0.4
Number of operations (self-reported)	0.3	0.5	1.1	1.1	-0.5	-0.1	0.9	-0.6
Pack years of smoking	0.3	0.4	1.1	-0.1	0.5	0.8	1.0	-0.0
Heel T-Score	0.2	1.6	5.1	-0.7	-0.9	-1.2	-2.3	0.4
Hypothyroidism (self reported)	0.2	0.5	1.1	-0.8	0.4	0.8	1.1	0.2
Tanning	0.2	2.5	6.7	1.8	-2.6	-0.6	-1.4	0.1
Ever used hormone-replacement therapy (HRT)	0.2	0.3	1.2	-0.1	-1.1	-0.0	-0.4	0.3
Medication: Metformin	0.2	0.3	0.7	-0.8	-0.1	-0.6	-0.5	-0.4
Pack years adult smoking proportion	0.2	0.3	0.8	-0.1	0.5	0.8	0.9	0.0
Hand grip strength (right)	0.2	0.6	1.5	-0.7	-0.2	-0.4	1.0	-1.2
Taking other prescription medications	0.2	0.3	0.9	0.9	0.1	0.2	0.6	0.1
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.6	0.5	-0.2	-0.2	0.5	-0.8
Medication: Atenolol	0.2	0.2	0.5	-0.1	0.7	0.2	0.6	-0.3
Sitting height	0.2	1.4	2.7	-0.4	1.6	1.3	1.5	0.1
Hearing difficulty/problems with background noise	0.2	0.3	0.6	0.8	0.1	0.5	0.0	0.6
Qualifications: None of the above	0.2	0.4	0.6	-0.7	-0.8	0.6	0.3	0.5
Mouth/teeth dental problems	0.2	0.3	1.0	-1.0	0.3	-0.4	0.1	-0.4
Medication: Ramipril	0.2	0.3	1.0	0.2	-0.2	0.4	-0.5	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.6	0.6	-0.5	-0.8	-0.8	-0.3
Number of live births	0.2	0.4	0.8	-0.9	-0.5	-0.6	0.4	-0.4
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.9	1.4	0.4	0.0	0.3	-0.2
Loud music exposure frequency	0.2	0.2	0.6	0.6	-0.8	-0.4	0.0	-0.2
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.1	1.0	-0.0	-0.6	0.2	-0.8
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.8	-0.9	0.5	0.3	0.7	-0.0
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.8	0.2	0.9	0.4	0.4	-0.3
Shortness of breath walking on level ground	0.2	0.2	0.9	0.3	-0.9	-0.1	-0.3	0.3
Qualifications: College or University degree	0.2	0.7	2.0	1.4	1.0	0.5	0.3	0.3
Eye problems/disorders: None of the above	0.2	0.2	0.4	-0.5	0.0	-0.6	-0.5	-0.2
Mean time to correctly identify matches	0.2	0.5	1.7	-1.3	0.5	-0.2	-0.5	-0.3
Overall health rating	0.2	0.4	0.7	-0.9	0.5	-0.7	-0.4	-0.6
Supplements: Vitamin C	0.2	0.2	0.9	0.0	0.9	0.2	0.4	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	0.7	-0.7	0.8	-0.2	0.4	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.2	0.2	0.6	-0.5	-0.1	0.8	0.0	0.6
Medication for cholesterol	0.2	0.3	0.8	-0.4	0.4	-0.5	-0.3	-0.9
Wears glasses or contact lenses	0.2	0.2	0.4	-0.7	0.5	0.1	0.3	-0.5
Medication: Paracetamol	0.2	0.4	0.7	0.8	0.4	0.1	0.7	-0.7
Fractured/broken bones in last 5 years	0.2	0.2	0.6	0.5	0.2	0.1	0.5	-0.8
Worry (Nagel 2018)	0.1	0.2	0.5	-0.5	0.2	0.5	0.2	0.7
Bipolar Disorder (2011)	0.1	0.1	0.4	0.0	0.0	0.0	0.0	0.6
Crohns Disease (2012)	0.1	0.1	0.2	0.5	0.2	0.2	0.2	0.3
Lupus	0.1	0.1	0.2	-0.2	-0.1	0.4	-0.3	0.4
Triglycerides	0.1	0.2	0.4	0.2	0.2	0.6	0.4	0.6
Blood Platelet Count	0.1	1.4	5.2	-2.3	1.2	0.2	-0.5	0.3
Height	0.1	1.8	3.9	-1.6	0.9	1.2	2.0	-0.3
Number of treatments/medications taken	0.1	0.1	0.4	0.6	-0.1	0.4	0.4	0.1
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.4	-0.6	0.3	0.3	0.3	-0.2
Medication: Levothyroxine sodium	0.1	0.1	0.3	-0.5	0.2	0.3	0.0	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.4	0.4	-0.7	-0.4	0.0	-0.2
Alcohol intake versus 10 years previously	0.1	0.2	0.9	0.9	0.1	-0.1	-0.1	0.2
Asthma	0.1	0.2	0.4	-0.3	0.3	-0.5	-0.3	-0.6
Prospective memory result	0.1	0.1	0.4	-0.0	-0.2	0.2	-0.0	0.7
Lung cancer (father)	0.1	0.2	0.5	0.4	-0.4	0.3	-0.1	0.7
Standing height	0.1	0.5	2.1	-1.4	0.1	0.6	0.4	-0.1
Length of working week for main job	0.1	0.1	0.4	0.6	-0.1	-0.3	-0.1	-0.4
Blood clot in the leg (DVT)	0.1	0.1	0.2	-0.4	0.3	-0.2	-0.5	0.2
Medication: Blood pressure	0.1	0.2	0.5	-0.5	-0.0	0.5	-0.4	0.7
Medication: Omeprazole	0.1	0.1	0.2	-0.2	-0.1	-0.2	-0.4	0.3
Alcohol intake frequency.	0.1	0.3	0.5	0.3	0.7	-0.5	0.6	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.3	0.3	0.1	0.0	-0.5	0.6
Loneliness, isolation	0.1	0.2	0.7	0.8	-0.1	0.2	-0.0	0.5
Miserableness	0.1	0.2	0.6	0.7	-0.8	0.1	-0.3	0.3
Commuting to job workplace: Public transport	0.1	0.2	0.4	0.2	0.6	0.3	0.6	-0.1
Diastolic blood pressure, automated reading	0.1	0.2	0.5	-0.2	-0.7	-0.4	0.3	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.5	-0.5	0.1	-0.4	-0.7	0.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.2	0.9	0.9	-0.3	0.1	0.2	0.3
Hair/balding pattern: Pattern 4	0.0	0.1	0.3	0.6	0.0	0.5	-0.1	0.0
Asthma (self-reported)	0.0	0.1	0.2	0.1	0.1	-0.2	-0.1	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.0	0.1	0.2	-0.2	-0.0	-0.2	-0.4	0.2

Hub : Genes

UBR2

Models

Trait associations