Best TWAS P=7.32e-11 · Best GWAS P=2.48e-08 conditioned to 0.000193
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Nucleus accumbens basal ganglia | RAD54L | 0.41 | 0.18 | lasso | 5 | 0.10 | 1.3e-03 | -5.6 | -6.5 | 7.3e-11 | 0.94 | 0.00 | 0.93 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | FAAH | 0.20 | 0.06 | enet | 27 | 0.14 | 8.6e-11 | 5.4 | 5.9 | 4.7e-09 | -0.46 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Esophagus Muscularis | NSUN4 | 0.09 | 0.03 | enet | 20 | 0.04 | 1.9e-03 | -5.5 | -5.4 | 6.6e-08 | 0.77 | 0.02 | 0.92 | FALSE |
| 4 | GTEx | Thyroid | FAAH | 0.16 | 0.06 | lasso | 3 | 0.08 | 1.9e-06 | -5.2 | -5.3 | 1.2e-07 | 0.91 | 0.00 | 1.00 | FALSE |
| 5 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | FAAH | 0.08 | 0.07 | lasso | 9 | 0.05 | 3.7e-03 | -5.5 | -5.5 | 3.4e-08 | 0.92 | 0.00 | 0.80 | FALSE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | UQCRH | 0.06 | 0.01 | blup | 45 | 0.01 | 2.9e-02 | 5.1 | -6.1 | 1.4e-09 | 0.47 | 0.01 | 0.37 | FALSE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | UQCRH | 0.05 | 0.03 | blup | 45 | 0.03 | 6.0e-04 | 4.7 | -5.2 | 2.4e-07 | 0.13 | 0.02 | 0.77 | TRUE |