Best TWAS P=2.92e-23 · Best GWAS P=8.87e-31 conditioned to 1.73e-10
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | JAK1 | 0.09 | 0.10 | lasso | 4 | 0.11 | 4.7e-13 | 6.02 | -7.0 | 2.0e-12 | -0.19 | 1.00 | 0.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | LEPR | 0.07 | 0.05 | enet | 15 | 0.06 | 5.1e-08 | 1.58 | 5.9 | 3.2e-09 | 0.32 | 0.90 | 0.09 | TRUE |
| 3 | GTEx | Brain Caudate basal ganglia | RAVER2 | 0.35 | -0.01 | lasso | 9 | -0.01 | 5.5e-01 | -0.75 | -6.5 | 9.6e-11 | -0.04 | 0.06 | 0.12 | TRUE |
| 4 | GTEx | Brain Cerebellar Hemisphere | JAK1 | 0.44 | 0.24 | enet | 56 | 0.23 | 1.3e-06 | 6.07 | -8.6 | 1.1e-17 | -0.25 | 0.36 | 0.26 | FALSE |
| 5 | GTEx | Brain Cerebellum | JAK1 | 0.48 | 0.27 | enet | 22 | 0.39 | 1.6e-12 | 6.07 | -5.8 | 5.8e-09 | -0.10 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Brain Cortex | JAK1 | 0.34 | 0.21 | lasso | 2 | 0.23 | 4.6e-07 | 6.02 | -6.1 | 8.9e-10 | -0.17 | 0.74 | 0.02 | FALSE |
| 7 | GTEx | Skin Not Sun Exposed Suprapubic | LEPROT | 0.17 | 0.01 | enet | 27 | 0.05 | 1.6e-03 | 3.18 | 8.1 | 4.5e-16 | 0.11 | 0.19 | 0.03 | TRUE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | JAK1 | 0.12 | 0.13 | bslmm | 478 | 0.12 | 3.6e-15 | 6.17 | -6.7 | 1.8e-11 | -0.22 | 1.00 | 0.00 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | RAVER2 | 0.33 | 0.32 | bslmm | 466 | 0.38 | 1.0e-51 | 1.63 | -5.8 | 7.4e-09 | -0.45 | 1.00 | 0.00 | TRUE |
| 10 | YFS | Blood | JAK1 | 0.02 | 0.01 | blup | 482 | 0.01 | 3.1e-04 | 8.61 | -9.9 | 2.9e-23 | -0.15 | 0.63 | 0.04 | TRUE |
| 11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | JAK1 | 0.08 | 0.08 | blup | 91 | 0.08 | 5.2e-09 | 6.02 | -7.5 | 6.5e-14 | -0.05 | 1.00 | 0.00 | FALSE |