Best TWAS P=1.38e-19 · Best GWAS P=2.57e-18 conditioned to 0.0171
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | RAMP3 | 0.05 | 0.00 | blup | 445 | 0.00 | 1.1e-01 | -1.8 | 5.7 | 1.4e-08 | 0.45 | 0.18 | 0.15 | FALSE |
| 2 | GTEx | Brain Cerebellum | CCM2 | 0.21 | 0.06 | lasso | 12 | 0.07 | 5.5e-03 | 8.7 | 6.7 | 2.4e-11 | 0.92 | 0.02 | 0.96 | FALSE |
| 3 | GTEx | Spleen | CCM2 | 0.29 | 0.11 | lasso | 8 | 0.07 | 7.8e-03 | 8.7 | 8.7 | 3.0e-18 | 0.98 | 0.01 | 0.91 | FALSE |
| 4 | GTEx | Stomach | TMED4 | 0.12 | 0.04 | enet | 8 | 0.04 | 5.4e-03 | 8.7 | 7.9 | 4.0e-15 | 0.96 | 0.01 | 0.97 | FALSE |
| 5 | GTEx | Testis | SNHG15 | 0.26 | 0.13 | enet | 17 | 0.18 | 2.0e-08 | -5.3 | 8.0 | 1.3e-15 | 0.64 | 0.16 | 0.84 | FALSE |
| 6 | GTEx | Whole Blood | CCM2 | 0.12 | 0.13 | enet | 19 | 0.14 | 1.3e-12 | 8.7 | 8.3 | 1.5e-16 | 0.99 | 0.01 | 0.99 | FALSE |
| 7 | METSIM | Adipose | CCM2 | 0.04 | 0.01 | bslmm | 453 | 0.02 | 5.5e-04 | 2.7 | 6.5 | 9.6e-11 | 0.69 | 0.04 | 0.93 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | NACAD | 0.04 | 0.01 | lasso | 3 | 0.02 | 2.8e-03 | 8.5 | 7.7 | 1.8e-14 | 0.84 | 0.02 | 0.94 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | CCM2 | 0.12 | 0.11 | lasso | 3 | 0.10 | 3.1e-13 | 8.6 | -8.4 | 2.9e-17 | -0.99 | 0.01 | 0.99 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | SNHG15 | 0.19 | 0.17 | lasso | 3 | 0.17 | 2.2e-21 | 7.0 | 7.1 | 1.1e-12 | 0.84 | 0.99 | 0.01 | FALSE |
| 11 | YFS | Blood | TBRG4 | 0.03 | 0.01 | lasso | 4 | 0.02 | 1.2e-08 | 4.3 | -7.2 | 6.3e-13 | -0.76 | 0.06 | 0.94 | FALSE |
| 12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C7orf40 | 0.03 | 0.04 | lasso | 1 | 0.04 | 7.0e-08 | 7.0 | 7.0 | 1.9e-12 | 0.84 | 0.06 | 0.94 | FALSE |
| 13 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C7orf40 | 0.03 | 0.02 | enet | 4 | 0.02 | 2.4e-03 | -5.6 | 7.3 | 2.3e-13 | 0.49 | 0.02 | 0.25 | FALSE |
| 14 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | C7orf40 | 0.12 | 0.08 | lasso | 3 | 0.09 | 5.8e-06 | 7.0 | 6.8 | 1.3e-11 | 0.80 | 0.03 | 0.94 | FALSE |
| 15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C7orf40 | 0.17 | 0.06 | enet | 24 | 0.05 | 7.7e-07 | 7.0 | 6.3 | 2.2e-10 | 0.59 | 0.15 | 0.85 | FALSE |
| 16 | The Cancer Genome Atlas | Lung Adenocarcinoma | C7orf40 | 0.04 | 0.03 | blup | 29 | 0.02 | 1.9e-03 | 7.0 | 9.1 | 1.4e-19 | 0.81 | 0.01 | 0.95 | TRUE |
| 17 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C7orf40 | 0.07 | 0.00 | blup | 29 | 0.01 | 9.0e-03 | 7.0 | 8.4 | 3.4e-17 | 0.66 | 0.01 | 0.57 | FALSE |
| 18 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | C7orf40 | 0.13 | 0.09 | lasso | 2 | 0.07 | 6.1e-04 | 7.0 | 7.2 | 5.7e-13 | 0.85 | 0.00 | 0.91 | FALSE |
| 19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C7orf40 | 0.15 | 0.05 | blup | 29 | 0.08 | 1.6e-08 | 7.0 | 7.9 | 2.9e-15 | 0.74 | 0.03 | 0.97 | FALSE |
| 20 | The Cancer Genome Atlas | Thyroid Carcinoma | C7orf40 | 0.10 | 0.05 | enet | 8 | 0.07 | 2.7e-07 | 7.0 | 7.0 | 3.5e-12 | 0.70 | 0.05 | 0.92 | FALSE |