TWAS hub - NACAD

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0540	0.0270	7.4e-03	0.013	0.013	0.001	0.013	0.003	8.6e-03	0.0078	2.2e-01	0.0081	1.2e-01
2	GTEx	Cells Transformed fibroblasts	0.1300	0.0340	6.6e-07	0.113	NA	0.098	NA	0.111	7.8e-09	NA	8.3e-08	NA	1.2e-08
3	GTEx	Lung	0.0709	0.0305	6.3e-03	0.025	NA	0.007	NA	0.020	5.0e-03	NA	8.7e-02	NA	1.1e-02
4	GTEx	Skin Sun Exposed Lower leg	0.1320	0.0430	2.7e-04	0.009	NA	0.047	NA	0.023	5.0e-02	NA	8.5e-05	NA	5.1e-03
5	ROSMAP	Brain Pre-frontal Cortex	0.0429	0.0189	5.1e-03	0.010	0.015	0.008	0.014	0.017	1.7e-02	0.0040	2.7e-02	0.0053	2.8e-03
6	TCGA	Breast Invasive Carcinoma	0.0151	0.0086	2.0e-03	0.016	0.002	-0.001	NA	0.000	2.3e-04	0.1100	7.3e-01	NA	2.5e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Smoking status: Current	6.3	10.0	17.6	2.4	-3.5	-2.2	-3.5	4.2	-2.7
Current tobacco smoking	6.0	9.8	17.1	2.1	-3.5	-2.0	-3.8	4.1	-2.6
Neuroticism (2016)	4.8	7.0	17.1	-4.1	2.5	2.5	-1.0	-2.4	2.4
Blood White Count	4.7	34.7	60.4	-6.1	7.2	7.8	3.7	0.5	6.7
Mouth/teeth dental problems: Mouth ulcers	4.7	7.4	11.6	-2.7	3.4	2.8	1.1	-2.7	3.1
Alcohol drinker status: Never	4.6	5.5	9.4	-2.1	3.1	2.7	-0.3	-1.9	2.9
Chronotype (morning person)	4.4	10.1	16.3	-4.0	3.9	2.9	1.2	-2.4	3.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.2	8.9	14.4	-2.3	3.2	3.1	1.9	-3.8	3.2
Father’s age at death	4.1	5.6	12.3	-2.5	2.1	2.1	1.0	-3.5	2.2
Commuting to job workplace: Car/motor vehicle	3.9	4.5	12.0	2.2	-2.0	-1.4	-0.3	3.5	-2.1
Medication: Omeprazole (e.g. Zanprol)	3.9	4.8	13.5	1.8	-2.0	-1.5	-1.8	3.7	-1.6
Mean Putamen Volume	3.6	4.1	7.6	2.1	-2.8	-2.1	-0.5	1.0	-2.6
Medication: Omeprazole	3.6	4.3	12.0	2.0	-1.9	-1.5	-1.2	3.5	-1.6
Miserableness	3.5	6.1	8.9	2.1	-3.0	-2.9	-1.2	2.3	-2.9
Frequency of depressed mood in last 2 weeks	3.4	4.7	7.6	1.7	-2.5	-2.5	-1.7	1.6	-2.8
Crohns Disease (2017)	3.3	7.3	13.1	-3.6	2.8	2.8	1.5	-2.1	2.8
Bipolar Disorder (2011)	3.3	3.2	7.6	-2.0	1.6	1.3	0.6	-2.8	1.8
Medication for cholesterol, blood pressure or diabetes	3.2	5.3	8.3	-2.4	2.9	2.5	1.3	-1.7	2.7
Heart disease (siblings)	3.2	4.0	5.8	-1.3	2.1	2.2	1.3	-2.4	2.3
Primary Biliary Cirrhosis	3.1	4.5	7.0	2.6	-2.1	-1.4	-2.6	1.9	-1.7
Number of children fathered	3.1	3.5	7.2	-1.1	1.9	1.2	2.7	-1.8	2.1
Age started oral contraceptive pill	3.1	3.9	7.0	-2.4	1.6	1.3	1.8	-2.6	1.8
Worry too long after embarrassment	3.0	5.0	7.7	-2.8	2.3	1.2	2.3	-2.6	1.9
Illness, injury, bereavement, stress in last 2 years	3.0	3.6	6.2	1.9	-2.0	-1.4	-1.3	2.5	-2.1
Pulse rate	2.9	4.9	8.6	2.9	-2.3	-2.5	-0.3	1.8	-2.4
Crohns Disease (2012)	2.8	4.4	7.4	-2.7	2.3	2.3	1.3	-1.5	2.2
Bilateral oophorectomy (both ovaries removed)	2.7	3.1	4.8	-1.6	2.0	2.2	0.8	-1.7	2.0
Medication: Levothyroxine sodium	2.7	4.5	11.0	3.3	-1.5	-2.1	-0.2	2.5	-1.8
Smoking Status	2.6	6.1	17.9	2.1	-2.2	-1.1	-4.2	2.5	-1.5
Hayfever/allergic rhinitis (self-reported)	2.6	3.5	7.9	2.3	-1.4	-1.4	-0.7	2.8	-1.8
Eye problems/disorders: Cataract	2.6	3.0	4.4	1.9	-2.0	-2.1	-0.7	1.1	-2.1
Mother’s age at death	2.6	3.3	6.1	-1.9	2.5	1.5	0.1	-2.0	2.0
Headache pain in last month	2.5	4.2	7.4	-2.0	2.3	1.6	1.8	-2.7	1.8
Risk taking	2.5	3.6	6.2	-2.5	2.1	2.0	-0.2	-1.5	2.2
Serious illness, injury or assault to yourself	2.4	2.9	4.5	-1.9	1.5	1.8	0.5	-1.9	2.1
Pulse wave reflection index	2.4	3.0	4.6	-2.1	1.4	1.6	1.8	-2.0	1.4
Supplements: Vitamin C	2.4	2.8	4.5	-1.6	2.1	2.0	0.5	-0.9	2.1
Diastolic blood pressure, automated reading	2.4	7.5	17.8	4.2	-2.5	-2.7	1.2	2.4	-2.5
Body Mass Index (BMI) (2010)	2.2	3.1	6.8	2.0	-1.6	-1.0	-1.0	2.6	-1.8
Blood Platelet Count	2.1	24.2	35.6	-5.1	6.0	5.9	4.3	-1.6	5.3
Eye problems/disorders: Diabetes related eye disease	2.1	2.3	6.3	-2.5	1.2	1.0	0.9	-1.8	1.2
Time employed in main current job	2.1	2.4	4.2	-0.8	2.1	1.5	1.3	-1.8	1.5
High blood pressure (mother)	2.0	2.8	4.8	-1.8	1.7	2.0	1.3	0.2	2.2
Forced expiratory volume in 1-second (FEV1), Best measure	2.0	6.5	10.2	-1.6	2.7	3.2	1.2	-2.8	3.1
Type 2 Diabetes (T2D) (2012)	1.9	2.2	6.8	1.6	-1.6	-0.7	0.2	2.6	-0.9
Lung FVC	1.9	9.9	15.7	-2.5	3.6	3.8	1.2	-3.0	4.0
Chronic bronchitis/emphysema (father)	1.9	2.2	6.8	1.4	-1.1	-0.5	-1.1	2.6	-1.2
Bipolar Disorder or Schizophrenia	1.8	4.4	11.7	-3.4	2.2	1.6	-0.7	-1.6	2.1
Alzheimer’s Disease (in father)	1.8	2.0	4.3	1.3	-1.6	-2.1	-0.4	-0.1	-1.7
Blood Eosinophil Count	1.8	13.8	58.7	2.8	-2.4	-0.8	-1.7	7.7	-2.7
Mouth/teeth dental problems: Dentures	1.8	3.0	4.6	1.8	-1.6	-2.1	0.1	2.1	-1.9
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	3.5	0.5	-1.9	-1.1	-1.9	1.6	-1.5
Depressed Affect (Nagel 2018)	1.7	3.6	4.9	0.8	-1.9	-1.9	-2.2	2.2	-2.0
Schizophrenia (2014)	1.7	3.7	10.5	-3.2	1.5	2.1	-0.9	-0.7	1.9
Systolic blood pressure, automated reading	1.7	5.1	7.3	2.6	-2.4	-2.1	-0.0	2.7	-2.4
Impedance of leg (right)	1.7	8.0	15.0	1.3	-3.6	-2.2	-3.9	2.3	-2.8
Taking other prescription medications	1.7	2.6	5.6	0.4	-1.2	-1.6	-2.0	2.4	-1.4
Medication: Blood pressure	1.7	3.0	4.7	1.6	-2.2	-2.0	-0.8	1.5	-2.0
Unable to work because of sickness or disability	1.7	2.2	3.2	1.3	-1.6	-1.8	-0.7	1.5	-1.7
Impedance of leg (left)	1.6	7.9	15.6	1.6	-3.7	-2.0	-4.0	2.2	-2.6
Systolic Blood Pressure	1.5	7.7	13.5	2.5	-3.1	-2.5	-1.3	3.7	-3.0
Number of treatments/medications taken	1.5	2.8	5.6	1.6	-1.6	-1.7	-0.2	2.4	-1.8
Number of incorrect matches in round	1.5	2.5	4.5	1.0	-2.1	-1.7	0.6	1.4	-2.0
Blood clot in the leg (DVT)	1.5	1.9	3.7	0.2	-1.7	-0.9	-1.9	1.5	-1.3
Medication: Bendroflumethiazide	1.5	2.3	5.1	1.7	-1.8	-0.8	-0.6	2.3	-1.3
Impedance of whole body	1.5	7.8	15.3	1.4	-3.7	-1.8	-3.9	2.4	-2.6
Irritable Bowel Disease (IBD)	1.4	3.4	5.7	-2.4	1.6	2.0	0.7	-1.7	2.1
Illnesses of father: High blood pressure	1.4	1.8	3.9	1.7	-1.4	-0.9	0.0	2.0	-1.0
Bipolar Disorder (2018)	1.3	2.1	4.3	-2.1	1.7	0.5	-0.9	-1.6	1.3
Schizophrenia (2018)	1.3	2.6	7.4	-2.7	1.5	1.6	-0.2	-0.8	1.6
Coronary Artery Disease (CAD)	1.3	1.5	3.5	1.1	-1.2	-1.9	-1.3	0.7	-0.7
Impedance of arm (left)	1.3	6.0	13.2	1.1	-3.1	-1.4	-3.6	2.3	-2.2
Breastfed as a baby	1.3	1.7	2.8	1.7	-1.3	-1.0	-1.0	1.2	-1.5
Body fat percentage	1.3	5.2	8.9	2.7	-2.2	-2.2	-0.3	3.0	-2.4
Osteoarthritis (self-reported)	1.3	1.7	3.2	1.8	-1.2	-1.8	-0.3	1.0	-1.1
Rheumatoid Arthritis	1.2	1.7	2.6	1.2	-1.3	-1.3	-0.1	1.6	-1.6
Respiratory disease	1.2	2.8	7.9	1.5	-1.4	-1.1	-0.7	2.8	-1.7
Diabetes (mother)	1.2	1.5	3.4	0.9	-1.8	-1.4	-0.1	0.8	-1.5
Trunk fat percentage	1.2	4.9	8.4	2.7	-2.1	-2.0	-0.5	2.9	-2.3
Relative age voice broke	1.2	1.8	3.2	0.7	-1.6	-0.7	-1.4	1.8	-1.3
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	3.6	-1.1	1.2	0.4	0.9	-1.9	0.9
Glaucoma (self-reported)	1.2	1.4	2.6	-1.6	0.6	-0.2	-1.6	-1.6	0.4
Forced vital capacity (FVC), Best measure	1.2	4.6	8.1	-0.9	2.5	2.8	0.5	-2.2	2.7
Wheeze or whistling in the chest in last year	1.2	2.1	6.7	0.1	-1.1	-1.3	-1.3	2.6	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	6.5	-0.8	0.3	-0.8	0.7	-2.5	-0.1
Back pain experienced in last month	1.2	1.7	4.0	0.0	1.5	1.3	-0.3	-2.0	1.4
Illnesses of father: None of the above (group 1)	1.2	1.5	3.0	-1.1	0.8	1.1	-1.5	-1.7	0.9
Basal cell carcinoma (self-reported)	1.2	1.4	5.6	-0.3	1.2	0.6	0.6	-2.4	0.7
Alzheimer’s Disease (including proxy)	1.1	1.6	4.0	0.6	-1.5	-2.0	0.5	0.2	-1.6
Maternal smoking around birth	1.1	1.6	3.9	0.9	-1.2	-1.0	-0.9	2.0	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.5	5.7	-2.4	1.3	2.2	-0.4	0.5	1.4
Had menopause	1.1	1.4	4.6	-1.1	0.8	0.7	-0.2	-2.1	1.2
Qualifications: None of the above	1.1	2.4	6.9	1.7	-1.4	-1.0	-0.1	2.6	-1.4
Qualifications: College or University degree	1.1	3.5	8.9	-1.7	2.0	1.1	-0.4	-3.0	1.9
Whole body fat mass	1.1	4.5	7.9	2.8	-1.8	-2.1	0.1	2.5	-2.2
Pulse rate, automated reading	1.1	3.4	5.5	2.2	-2.0	-2.0	0.1	1.4	-2.4
Ever depressed for a whole week	1.1	1.3	3.2	-1.6	0.3	0.1	-1.3	-1.8	0.5
Commuting to job workplace: Cycle	1.1	1.4	2.8	-0.6	1.7	1.3	0.6	-1.1	1.4
Lupus	1.0	1.5	3.5	-0.0	1.9	1.7	0.1	-0.8	1.4
Trunk fat mass	1.0	4.5	7.8	2.8	-1.9	-2.0	-0.1	2.5	-2.2
Waist circumference	1.0	3.5	6.3	2.2	-1.5	-2.0	0.1	2.5	-1.9
Allergy	1.0	2.4	5.6	-2.2	0.6	1.0	1.0	-2.4	1.4
Alcohol intake versus 10 years previously	1.0	1.5	3.4	1.4	-0.8	-1.9	-0.2	0.9	-1.6
Forced expiratory volume in 1-second (FEV1)	1.0	3.4	5.2	-0.9	2.0	2.2	1.0	-2.1	2.3
Asthma	1.0	1.9	4.7	1.8	-0.9	-1.1	-0.2	2.2	-1.4
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	6.6	2.6	-0.5	-1.1	0.6	1.5	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	3.4	-0.8	1.4	1.8	0.7	-1.7	1.8
Arm fat percentage (left)	1.0	3.9	7.7	2.2	-1.7	-1.9	0.2	2.8	-2.1
Tinnitus: Yes, now most or all of the time	1.0	1.1	2.6	1.0	-1.6	-1.0	-0.6	0.8	-1.0
Ever smoked	1.0	1.8	7.1	0.5	-1.1	-0.7	-2.7	1.2	-0.7
Vascular/heart problems diagnosed by doctor	1.0	2.7	4.2	-2.1	1.9	1.6	0.5	-1.8	1.6
Pain experienced in last month	1.0	1.6	3.8	1.1	-2.0	-0.9	0.3	1.5	-1.2
HDL Cholesterol	0.9	1.5	2.8	-0.5	-1.7	-1.4	-1.2	1.0	-1.2
Waist Hip Ratio (WHR)	0.9	4.1	9.2	0.8	-2.5	-1.4	-1.8	3.0	-1.9
Cardiovascular Disease	0.9	3.0	8.3	1.5	-1.7	-1.2	-1.0	2.9	-1.5
Sensitivity / hurt feelings	0.9	1.6	2.3	-1.1	1.4	1.5	0.9	-1.0	1.4
Vitamin and mineral supplements	0.9	1.2	4.8	2.2	-0.9	-0.7	0.1	0.7	-0.9
Medication: Co-codamol	0.9	1.0	5.2	0.6	0.3	0.4	2.3	0.1	0.6
Diabetes (father)	0.9	1.1	5.9	0.4	-0.7	-0.1	0.2	2.4	-0.5
Past tobacco smoking	0.9	1.7	5.0	-1.1	1.1	0.6	2.2	-1.3	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	3.8	0.0	-1.5	-2.0	-0.6	-0.3	-1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	5.5	-2.4	1.1	1.9	0.1	0.0	1.2
Worrier / anxious feelings	0.9	1.8	3.7	-1.9	1.6	0.6	1.2	-1.1	1.0
Length of working week for main job	0.9	1.0	2.0	-1.1	1.4	0.7	1.0	-0.6	1.0
Medication: Ventolin 100micrograms inhaler	0.9	1.2	2.2	0.5	-0.9	-1.3	0.9	1.5	-1.2
Leg fat percentage (right)	0.9	3.3	5.5	2.0	-1.4	-2.0	0.5	2.3	-2.0
Pulse wave peak to peak time	0.9	1.1	3.2	0.6	-0.8	-0.6	-1.2	1.8	-0.5
Medication: Seretide 50 evohaler	0.9	1.1	1.9	0.6	-1.4	-1.1	0.4	1.0	-1.2
Leg pain on walking	0.9	1.2	2.9	1.0	-0.4	-0.1	1.5	1.7	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	2.8	-0.6	1.2	0.0	0.8	-1.7	0.9
Ever taken oral contraceptive pill	0.9	1.0	2.7	0.3	-0.9	-0.1	1.3	1.6	-0.7
Financial situation satisfaction	0.9	1.1	2.1	0.2	-1.2	-1.4	-1.1	-0.3	-1.3
Eye problems/disorders: Glaucoma	0.9	1.1	2.3	-1.2	0.8	0.4	-1.3	-1.5	0.6
Leg fat percentage (left)	0.9	3.3	5.3	2.3	-1.4	-1.8	0.6	2.3	-1.8
Alcohol drinker status: Previous	0.9	1.0	1.4	1.1	-0.9	-0.7	-1.1	1.2	-1.0
Depression (Nagel 2018)	0.8	1.2	1.8	0.7	-1.3	-1.0	-1.3	0.9	-1.4
Alzheimer’s Disease (in mother)	0.8	1.0	2.3	0.3	-0.8	-1.5	1.3	-0.1	-1.0
Reaction Time	0.8	1.5	3.0	1.6	-1.2	-0.7	0.6	1.7	-1.1
Fasting Glucose	0.8	1.0	1.9	0.6	-1.4	-0.8	-0.9	1.1	-1.1
LDL Cholesterol	0.8	1.3	4.5	2.1	-0.8	-1.1	0.2	0.6	-1.1
Height	0.8	15.7	25.9	5.1	-4.4	-4.1	-3.3	1.1	-4.4
Hayfever, allergic rhinitis or eczema	0.8	1.8	5.4	2.3	-0.3	-0.9	0.3	1.8	-1.0
Forced vital capacity (FVC)	0.8	3.1	5.1	-0.8	2.1	2.2	0.5	-1.9	2.3
Arm fat percentage (right)	0.8	3.0	6.5	1.7	-1.4	-1.8	0.3	2.5	-1.9
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	2.2	0.8	-1.5	-1.4	-0.8	0.7	-1.4
Medication: Cholesterol lowering	0.8	1.3	2.3	1.0	-1.5	-1.5	-0.3	-0.2	-1.4
Birth weight of first child	0.8	1.4	2.3	0.9	-1.1	-1.4	-0.5	1.5	-1.3
Migraine (self-reported)	0.8	1.0	2.7	0.5	0.8	0.7	1.6	-1.1	0.7
Medication: Ibuprofen	0.8	0.9	4.4	-0.6	0.7	-0.1	0.2	-2.1	0.4
Leg fat mass (right)	0.8	3.0	4.7	2.2	-1.3	-1.8	0.6	2.1	-1.8
Chest pain or discomfort	0.8	1.2	2.5	-0.1	1.3	1.6	0.7	-0.0	1.5
Age at last live birth	0.8	1.1	2.0	-1.4	1.3	0.8	-0.1	-1.4	0.8
Hypertension (Self-reported)	0.8	2.3	3.4	1.8	-1.8	-1.4	-0.3	1.7	-1.5
Illnesses of father: Heart disease	0.8	1.0	3.3	-0.6	0.8	0.3	1.8	-0.9	1.0
Asthma (self-reported)	0.8	1.7	4.6	1.5	-0.8	-0.9	-0.2	2.1	-1.3
Arm fat mass (left)	0.8	3.5	5.5	2.3	-1.4	-1.9	0.6	2.3	-1.9
Irritability	0.8	1.3	4.9	-2.2	0.9	0.8	-0.7	-0.6	0.8
Leg fat mass (left)	0.8	2.9	5.3	2.3	-1.3	-1.7	0.7	2.1	-1.7
Intelligence (Savage-Jansen 2018)	0.7	2.0	4.8	2.2	-1.7	-1.1	-0.9	0.4	-1.6
Schizophrenia vs Biploar Disorder	0.7	0.9	3.0	-0.4	-0.9	0.1	-1.0	1.7	-0.5
Severe depression (siblings)	0.7	0.7	1.7	-0.8	0.9	0.8	1.3	-0.3	0.6
Pack years adult smoking proportion	0.7	1.1	2.7	-0.1	-0.8	-1.2	-0.1	1.6	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.5	0.6	-1.2	-0.7	-0.5	1.2	-1.2
High blood pressure	0.7	2.1	3.2	1.8	-1.7	-1.3	-0.1	1.6	-1.4
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	2.4	0.1	-0.9	-1.0	-1.5	0.1	-0.8
Medication: Simvastatin	0.7	1.0	1.9	0.8	-1.4	-1.2	0.6	0.9	-1.0
Impedance of arm (right)	0.7	3.2	8.7	-0.2	-2.3	-0.7	-2.9	1.6	-1.4
Qualifications: A levels/AS levels or equivalent	0.7	1.6	4.0	-1.5	1.2	0.4	-0.1	-2.0	1.2
Arm fat mass (right)	0.7	2.8	4.4	2.1	-1.1	-1.7	0.8	2.0	-1.7
Exposure to tobacco smoke at home	0.7	0.7	2.3	0.6	-0.2	-1.5	-0.1	-0.5	-1.2
Peak expiratory flow (PEF)	0.7	1.7	2.8	-0.5	1.2	1.2	1.3	-1.7	1.6
Medication: Paracetamol	0.7	1.2	2.5	-0.1	1.5	0.8	1.6	-0.7	1.2
High blood pressure (siblings)	0.7	1.0	2.1	-0.7	0.6	1.3	1.4	0.5	0.9
Mean time to correctly identify matches	0.7	1.4	2.6	1.4	-1.1	-0.8	0.4	1.6	-1.2
Alcohol intake frequency.	0.7	1.6	3.4	-0.3	1.6	1.9	1.5	0.2	1.3
Comparative height size at age 10	0.7	4.0	6.8	2.6	-2.1	-1.9	-1.6	1.2	-2.2
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	1.6	-1.2	1.2	0.7	0.8	-0.4	0.9
Commuting to job workplace: Walk	0.7	0.7	2.0	-0.8	-0.0	0.1	-1.4	-1.2	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.6	0.8	0.6	0.9	1.6	-0.0	0.8
Number of self-reported non-cancer illnesses	0.7	1.2	2.4	1.2	-1.1	-1.6	-0.4	0.8	-1.2
Medication: Paracetamol	0.7	1.1	2.6	0.2	1.4	0.7	1.6	-0.7	1.1
Cholesterol lowering medication	0.7	1.0	2.8	-0.1	0.3	1.2	1.7	0.7	1.0
Pack years of smoking	0.7	1.0	2.9	-0.3	-0.7	-1.1	-0.1	1.7	-1.1
Major Depression (MDD)	0.6	0.8	1.3	0.8	-1.1	-0.7	-0.6	1.2	-0.8
Allergy or Eczema	0.6	1.6	3.9	2.0	-0.2	-0.6	1.0	1.9	-0.8
Ever used hormone-replacement therapy (HRT)	0.6	0.7	2.5	-0.2	-0.7	-1.0	1.6	-0.7	-0.1
Hand grip strength (right)	0.6	1.5	6.9	2.6	-1.1	-0.4	-0.1	0.8	-0.4
Average weekly fortified wine intake	0.6	0.7	2.5	0.2	0.1	-0.4	1.6	-1.3	-0.1
Fed-up feelings	0.6	1.1	1.4	0.8	-1.0	-1.2	-0.9	1.0	-1.2
Hair/balding pattern: Pattern 2	0.6	0.7	2.4	-0.2	0.3	0.6	1.5	-1.1	0.6
Fluid intelligence score	0.6	1.2	3.2	1.8	-0.8	-0.8	-1.5	-0.2	-0.7
Hip circumference	0.6	2.4	6.0	2.5	-0.7	-1.8	0.7	1.4	-1.5
Prospective memory result	0.6	0.8	1.9	-1.4	1.0	0.8	-0.1	-0.3	1.0
Pulse wave Arterial Stiffness index	0.6	0.7	2.7	-0.4	0.5	0.4	1.0	-1.6	0.3
Standing height	0.6	5.7	8.4	2.9	-2.8	-2.3	-2.5	0.6	-2.5
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.5	0.8	-1.0	-1.2	-0.1	0.4	-1.2
Emphysema/chronic bronchitis	0.6	0.6	1.2	-0.3	-1.1	-0.8	-0.6	0.8	-0.9
Neck or shoulder pain in last month	0.6	0.9	1.9	-0.9	1.2	0.3	1.4	-0.8	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.8	0.6	-0.7	-0.7	-1.4	0.9	-0.4
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.4	-0.6	1.1	0.8	1.2	-0.5	0.8
Qualifications: nursing, teaching	0.6	0.9	1.9	-0.5	1.2	0.9	0.2	-1.4	1.0
Guilty feelings	0.6	0.8	3.8	-1.9	0.6	-0.1	-0.0	-0.9	0.4
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.7	0.8	-0.3	-0.6	-1.2	1.3	-0.7
Fractured/broken bones in last 5 years	0.6	0.8	2.7	-1.6	-0.1	0.4	0.1	-1.3	0.2
Age at First Birth	0.5	0.8	3.6	-0.3	-0.0	-1.0	-0.3	-1.9	0.2
Heel T-Score	0.5	4.2	10.2	-1.4	1.6	3.2	-0.6	2.1	2.4
Hypothyroidism (self reported)	0.5	1.2	3.8	1.9	-0.3	-0.8	0.9	1.3	-0.8
Relative age of first facial hair	0.5	1.0	3.5	0.2	-0.5	1.4	-0.5	1.9	0.4
Sitting height	0.5	3.4	9.0	3.0	-0.9	-1.8	-2.1	-1.1	-1.1
Hearing difficulty/problems with background noise	0.5	0.8	1.3	-0.8	0.7	1.1	-1.1	0.6	0.8
Neuroticism score	0.5	0.9	3.6	-1.9	0.9	0.1	0.0	-1.0	0.5
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	3.1	-0.5	0.7	0.5	0.4	-1.8	0.7
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.0	-0.6	-0.6	-0.7	-1.4	0.3	-0.9
Number of full sisters	0.5	0.5	1.2	1.1	-0.5	-0.3	0.6	1.1	-0.5
Loneliness, isolation	0.5	0.7	2.6	-0.7	-0.7	-0.6	-1.6	0.3	-0.6
Ever had bowel cancer screening	0.5	0.6	2.2	0.3	0.2	-0.8	0.5	-1.5	-0.1
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.8	-0.4	0.8	0.1	0.8	-1.3	0.5
Worry (Nagel 2018)	0.4	0.8	2.1	-1.4	1.0	0.1	0.2	-1.2	0.7
HbA1C	0.4	0.5	1.2	0.1	0.8	0.3	0.6	-1.1	0.8
Blood Red Count	0.4	4.2	8.4	-2.9	2.2	1.5	2.0	-1.3	2.1
Neuroticism	0.4	1.0	3.5	-1.9	1.1	0.5	-0.5	-0.7	0.7
Hand grip strength (left)	0.4	0.9	4.8	2.2	-0.7	0.2	-0.4	0.5	-0.2
Average weekly spirits intake	0.4	0.5	1.9	-0.2	-0.4	0.3	-1.0	1.4	-0.2
Hearing difficulty/problems: Yes	0.4	0.7	1.6	-0.7	0.0	0.5	-1.2	1.3	0.3
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	2.4	1.6	-0.3	-0.5	-0.2	0.5	-0.3
Angina	0.4	0.5	1.0	-0.6	1.0	0.3	0.6	-0.6	1.0
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.2	1.1	0.0	-0.8	0.2	-0.5	-0.6
Multivitamins +/- minerals	0.4	0.5	3.0	-1.7	0.2	-0.1	0.1	-0.2	0.2
Stomach or abdominal pain in last month	0.4	0.5	1.0	-0.3	1.0	0.6	0.9	-0.0	0.8
Medication: Atenolol	0.4	0.5	0.7	0.0	0.8	0.7	0.8	-0.4	0.9
Alcohol usually taken with meals	0.4	0.7	1.6	0.3	-0.7	-1.3	-0.7	-1.0	-0.7
Heart attack	0.4	0.5	2.5	1.6	-0.2	-0.6	-0.5	-0.2	-0.2
Medication: Ramipril	0.4	0.5	0.9	0.3	-0.5	-0.8	-0.9	0.5	-0.9
Weight	0.4	2.0	5.4	2.3	-0.7	-1.5	0.7	1.3	-1.3
Hair/balding pattern: Pattern 3	0.4	0.6	1.8	0.5	0.3	0.4	-1.2	1.3	0.4
Happiness	0.4	0.5	1.8	0.0	-0.8	-0.6	-1.4	0.1	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	2.1	-0.2	0.1	-0.8	-0.1	-1.4	-0.2
Depression (self-reported)	0.4	0.5	1.1	-0.4	-0.2	-0.8	-1.0	0.3	-0.8
Medication: Lansoprazole	0.4	0.4	0.8	-0.5	0.6	0.9	0.9	-0.2	0.7
Medication: Amlodipine	0.4	0.6	2.2	0.4	-0.3	0.2	-0.9	1.5	-0.4
Comparative body size at age 10	0.4	1.2	3.5	1.0	1.1	0.9	1.9	-0.0	0.7
Medication: Aspirin	0.4	0.6	1.0	0.4	-0.7	-0.8	-1.0	0.8	-0.6
Medication: Gliclazide	0.4	0.4	1.3	0.4	-1.2	-0.6	0.3	0.3	-0.7
Wears glasses or contact lenses	0.4	0.5	0.9	0.5	-0.8	-1.0	-0.7	0.4	-0.8
Hearing aid user	0.4	0.5	1.2	-0.8	0.7	1.1	0.2	0.5	0.6
Commuting to job workplace: Public transport	0.4	0.5	2.1	-0.6	0.5	-0.3	0.1	-1.4	0.3
High cholesterol (Self-reported)	0.4	0.8	1.6	1.2	-0.9	-0.6	0.6	1.0	-0.7
Myopia	0.4	0.5	1.0	1.0	-0.6	-0.6	-0.3	1.0	-0.6
Heart attack/myocardial infarction (self-reported)	0.4	0.5	2.2	1.5	-0.3	-0.7	-0.4	-0.2	-0.3
Ulcerative Colitis (UC)	0.3	0.5	1.4	-0.7	0.2	0.6	-0.4	-1.2	0.7
Triglycerides	0.3	0.4	2.0	1.4	0.5	0.4	0.0	-0.2	0.2
BMI	0.3	1.8	4.9	1.5	-0.3	-0.6	1.7	2.2	-0.7
Medication for hormone replacement therapy	0.3	0.4	1.2	-1.1	0.3	0.0	0.7	-0.6	0.2
Supplements: Zinc	0.3	0.4	1.8	-0.4	-0.1	-0.4	-1.3	-0.2	-0.1
Townsend deprivation index at recruitment	0.3	0.4	1.3	0.2	-0.5	0.6	0.4	1.2	-0.1
Age when periods started (menarche)	0.3	0.7	1.5	0.2	1.0	1.0	-0.1	-0.6	1.2
Qualifications: CSEs or equivalent	0.3	0.4	1.6	-0.3	0.2	0.9	-0.2	1.3	0.2
Supplements: Glucosamine	0.3	0.4	1.0	-0.9	0.6	-0.4	0.3	-1.0	0.5
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.0	0.9	-0.1	0.3	-0.2	1.0	-0.2
Body mass index (BMI)	0.3	1.3	4.0	1.2	0.4	-0.6	2.0	1.2	-0.4
Nervous feelings	0.3	0.6	1.3	-1.1	0.7	0.4	0.8	-0.4	0.9
Number of live births	0.3	0.4	2.1	0.3	-0.2	-0.3	-0.1	1.5	-0.1
Lung cancer (father)	0.3	0.3	0.7	-0.8	-0.5	0.5	-0.6	-0.4	-0.1
Illnesses of mother	0.3	0.3	0.7	0.3	0.7	0.7	-0.2	-0.8	0.5
Tense / ‘highly strung’	0.3	0.6	1.9	-1.4	0.2	-0.8	0.0	-0.9	-0.1
Ever highly irritable/argumentative for 2 days	0.3	0.4	2.0	-0.2	-0.1	0.2	-0.2	-1.4	-0.1
Gout (self-reported)	0.3	0.4	1.0	-0.8	-0.6	-0.2	-1.0	-0.3	-0.3
Birth weight	0.3	0.6	1.6	0.0	0.4	1.3	0.7	-0.2	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	1.4	0.4	-0.2	-0.3	0.5	1.2	-0.4
Shortness of breath walking on level ground	0.3	0.3	0.9	0.9	0.2	-0.5	0.6	-0.5	-0.2
Medication for pain relief, constipation, heartburn	0.3	0.5	1.0	-0.8	0.5	1.0	0.3	-0.9	0.5
Medication: Allopurinol	0.3	0.4	1.4	-1.2	-0.4	-0.5	-0.4	-0.6	-0.3
Arm predicted mass (right)	0.3	1.4	4.5	2.1	-0.4	-1.2	1.1	0.1	-0.9
Medication: Aspirin	0.3	0.4	0.9	0.2	-0.7	-0.6	-0.9	0.8	-0.5
Smoking status: Previous	0.3	0.4	2.1	0.2	0.3	0.5	-1.4	-0.2	0.3
Average weekly red wine intake	0.3	0.4	2.0	0.0	0.5	-0.2	0.0	-1.4	0.2
Osteoporosis (self-reported)	0.3	0.4	0.9	-0.3	0.9	0.8	0.0	-0.6	0.7
Average weekly champagne plus white wine intake	0.3	0.5	2.0	0.5	-0.4	-0.3	-0.5	-1.4	-0.2
Supplements: Fish oil (including cod liver oil)	0.3	0.3	1.8	0.1	0.2	-0.2	1.3	-0.0	0.4
Medication: Atorvastatin	0.3	0.3	1.0	-0.7	0.1	0.3	0.6	-1.0	0.1
Number of operations (self-reported)	0.3	0.5	2.0	1.4	0.2	-0.6	0.5	0.0	0.0
Neuroticism (Nagel 2018)	0.2	0.4	1.4	-1.2	0.5	-0.3	-0.8	-0.0	0.0
Verbal and Numeric Reasoning (VNR)	0.2	0.5	2.6	1.6	-0.4	-0.2	-0.4	-0.0	-0.5
Ovarian Cancer	0.2	0.2	0.8	0.2	-0.4	0.2	-0.9	-0.5	0.2
Prostate Cancer	0.2	0.3	0.6	-0.3	-0.7	-0.7	0.8	0.4	-0.4
Ulcerative Colitis	0.2	0.3	1.0	0.1	-0.3	-0.1	-0.8	-1.0	0.3
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.9	-0.2	-0.9	-0.6	0.2	0.4	-0.7
Ever had hysterectomy (womb removed)	0.2	0.2	0.8	0.1	0.3	0.3	-0.2	-0.9	0.6
Medication: Metformin	0.2	0.3	1.0	-1.0	-0.7	-0.1	-0.3	-0.4	-0.4
Leg fat-free mass (left)	0.2	0.9	3.7	1.0	0.8	-0.2	1.9	-0.5	0.1
Leg predicted mass (left)	0.2	1.0	4.0	1.0	0.8	-0.1	2.0	-0.5	0.2
Financial difficulties in last 2 years	0.2	0.2	1.2	-0.2	0.1	-0.1	1.1	-0.3	0.1
Pain all over the body in last month	0.2	0.2	0.7	0.8	0.1	-0.3	0.1	0.6	0.1
Diabetes (self-reported)	0.2	0.2	0.9	-1.0	-0.1	0.2	-0.2	-0.7	0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.4	-1.2	-0.2	-0.2	0.5	0.5	-0.1
Hair/balding pattern: Pattern 4	0.2	0.6	2.0	-0.0	-0.4	-1.4	0.3	-1.0	-0.6
Loud music exposure frequency	0.2	0.2	0.5	0.5	-0.3	0.3	0.5	0.7	-0.2
Arm fat-free mass (right)	0.2	1.1	3.1	1.8	-0.0	-0.9	1.5	-0.2	-0.5
Age at first live birth	0.2	0.4	1.8	-0.3	0.1	-0.2	-0.6	-1.4	-0.1
Mouth/teeth dental problems: Loose teeth	0.2	0.2	1.1	-0.3	-0.2	-0.2	-0.2	1.1	-0.3
Angina (self-reported)	0.2	0.2	0.5	-0.3	0.7	-0.0	0.5	-0.5	0.6
Had major operations	0.2	0.2	0.6	0.5	0.1	-0.3	-0.5	-0.8	0.3
Family relationship satisfaction	0.2	0.3	0.6	-0.6	-0.6	0.0	-0.4	0.8	-0.2
Knee pain experienced in last month	0.2	0.4	0.8	0.9	0.1	-0.9	-0.1	-0.4	-0.8
Illnesses of siblings: Diabetes	0.2	0.2	1.0	0.1	-0.0	1.0	0.1	0.2	0.5
Whole body fat-free mass	0.2	0.9	3.1	1.2	0.6	-0.4	1.8	-0.7	-0.1
Leg fat-free mass (right)	0.2	1.2	4.5	0.9	1.0	0.1	2.1	-0.8	0.5
Mood swings	0.2	0.4	1.8	-1.3	0.1	0.2	0.4	-0.1	0.4
Long-standing illness, disability or infirmity	0.2	0.4	1.1	1.1	-0.5	-0.4	0.2	0.5	-0.6
Diabetes diagnosed by doctor	0.2	0.3	0.7	-0.5	-0.7	-0.2	-0.3	-0.8	-0.3
Mineral and other dietary supplements	0.2	0.3	1.0	0.1	-0.2	0.7	-0.5	1.0	-0.2
Whole body water mass	0.2	0.9	2.8	1.3	0.4	-0.6	1.7	-0.6	-0.2
Leg predicted mass (right)	0.2	1.1	4.0	0.9	1.0	0.1	2.0	-0.7	0.4
Basal metabolic rate	0.2	1.0	2.6	1.6	0.1	-0.8	1.5	-0.1	-0.5
Arm fat-free mass (left)	0.2	1.0	3.5	1.3	0.4	-0.6	1.9	-0.4	-0.2
Supplements: Calcium	0.2	0.2	0.7	-0.8	0.1	0.0	-0.6	0.5	-0.1
Arm predicted mass (left)	0.2	1.1	2.9	1.5	0.0	-0.9	1.7	-0.4	-0.6
Had other major operations	0.1	0.2	0.8	0.3	0.3	0.1	0.3	0.9	-0.0
Mouth/teeth dental problems	0.1	0.2	0.5	0.7	0.1	0.5	0.2	-0.4	0.4
Illnesses of siblings	0.1	0.2	0.5	-0.3	0.3	-0.4	-0.3	-0.7	-0.1
Trunk fat-free mass	0.1	0.8	1.8	1.2	0.3	-0.8	1.4	-0.8	-0.4
Falls in the last year	0.1	0.1	0.3	0.4	0.5	-0.5	-0.0	-0.3	-0.2
Noisy workplace	0.1	0.1	0.6	-0.8	0.0	0.2	0.2	0.2	-0.1
Trunk predicted mass	0.1	0.8	1.8	1.2	0.3	-0.8	1.4	-0.7	-0.4
Exposure to tobacco smoke outside home	0.1	0.1	0.2	-0.3	0.5	-0.2	0.2	-0.5	-0.3
Health satisfaction	0.1	0.1	0.2	0.2	-0.4	-0.5	-0.4	-0.0	-0.1
Eye problems/disorders: None of the above	0.1	0.1	0.4	0.4	0.4	0.2	0.6	0.3	0.2
Heart disease (mother)	0.1	0.2	0.4	0.1	-0.4	-0.1	0.5	0.7	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.2	0.2	-0.2	0.5	-0.2	0.4	-0.1
Suffer from ‘nerves’	0.1	0.2	0.5	-0.7	-0.0	-0.6	0.1	-0.4	-0.1
Overall health rating	0.1	0.3	0.8	0.3	-0.4	-0.9	0.2	0.4	-0.8
Friendships satisfaction	0.1	0.1	0.3	-0.4	-0.4	-0.4	-0.5	-0.1	-0.1
Medication for cholesterol	0.1	0.2	0.7	-0.0	-0.3	0.0	-0.8	-0.6	-0.3
Breast cancer (self-reported)	0.1	0.1	0.3	0.1	0.5	0.6	-0.3	0.2	0.3
Medication: Blood pressure	0.1	0.2	0.8	0.4	-0.2	-0.1	0.3	0.9	-0.2
Medication: Lisinopril	0.1	0.1	0.2	0.4	-0.4	0.1	0.1	0.4	-0.1
Average weekly beer plus cider intake	0.1	0.1	0.4	-0.6	0.3	-0.4	-0.2	0.2	-0.3
Breast Cancer	0.0	0.1	0.3	0.2	-0.0	-0.3	-0.6	0.0	-0.3
Lung FEV1/FVC ratio	0.0	0.2	0.8	-0.2	-0.9	-0.1	-0.2	0.3	-0.2
Hair Pigment	0.0	0.6	1.3	1.1	-0.9	-0.7	-0.5	0.5	-0.7
Tanning	0.0	0.2	0.6	0.8	-0.7	-0.3	0.2	0.1	-0.4
Number of full brothers	0.0	0.0	0.1	-0.1	0.1	0.2	0.0	-0.2	-0.0

Hub : Genes

NACAD

Models

Trait associations